Scholars@Duke
Douglas David Schocken

Douglas David Schocken

Professor Emeritus of Medicine
Medicine, Cardiology
douglas.schocken@duke.edu
Duke Box 3126, Duke University Medical Center, Durham, NC 27710-0001
15 Barrington Place, Durham, NC 27705

Selected Publications

BMI, waist circumference, and waist-to-hip trajectories and all-cause, CVD, and cancer mortality by sex in people without diabetes.

Journal Article Int J Obes (Lond) · April 9, 2025 OBJECTIVES: We examined the associations of BMI, waist circumference, and waist-to-hip ratio trajectories with mortality in people without diabetes. METHODS: We analyzed 7601 people without diabetes from the Atherosclerosis Risk in Communities Study. We us ... Full text Link to item Cite

Sex-specific optimal cut-off points for metabolic health indicators to predict incident type 2 diabetes mellitus.

Journal Article Nutr Metab Cardiovasc Dis · February 28, 2025 BACKGROUND AND AIM: We aimed to determine the optimal cut-off points for metabolic health indicators, including insulin resistance (IR), glucose, insulin, BMI, and waist circumference, in middle-aged nondiabetic people to predict future type 2 diabetes mel ... Full text Link to item Cite

Course and trajectories of insulin resistance, incident heart failure and all-cause mortality in nondiabetic people.

Journal Article Endocrine · February 2025 BACKGROUND: In nondiabetic people, the long-term effects of insulin resistance (IR) on heart failure (HF) and all-cause mortality have not been studied. OBJECTIVES: To examine the association between IR trajectories and incident HF and all-cause mortality ... Full text Link to item Cite

Longitudinal blood glucose level and increased silent myocardial infarction: a pooled analysis of four cohort studies.

Journal Article Cardiovasc Diabetol · April 18, 2024 BACKGROUND: Fasting glucose (FG) demonstrates dynamic fluctuations over time and is associated with cardiovascular outcomes, yet current research is limited by small sample sizes and relies solely on baseline glycemic levels. Our research aims to investiga ... Full text Link to item Cite

ISE/ISHNE expert consensus statement on the ECG diagnosis of left ventricular hypertrophy: The change of the paradigm.

Journal Article Ann Noninvasive Electrocardiol · January 2024 The ECG diagnosis of LVH is predominantly based on the QRS voltage criteria. The classical paradigm postulates that the increased left ventricular mass generates a stronger electrical field, increasing the leftward and posterior QRS forces, reflected in th ... Full text Link to item Cite

Preventing new-onset heart failure: Intervening at stage A.

Journal Article Am J Prev Cardiol · December 2023 Heart failure (HF) prevention is an urgent public health need with national and global implications. Stage A HF patients do not show HF symptoms or structural heart disease but are at risk of HF development. There are no unique recommendations on detecting ... Full text Link to item Cite

Abstract 09: Trajectories of Insulin Resistance, Incident Heart Failure and All-Cause Death in Nondiabetics: The Atherosclerosis Risk in Communities Study

Conference Circulation · February 28, 2023 Introduction: Previous studies have suggested an association between insulin resistance (IR) trajectories and adverse changes in cardiac structure and function in nondiabetic populations. We studied t ... Full text Cite

ISE/ISHNE Expert Consensus Statement on ECG Diagnosis of Left Ventricular Hypertrophy: The Change of the Paradigm. The joint paper of the International Society of Electrocardiology and the International Society for Holter Monitoring and Noninvasive Electrocardiology.

Journal Article J Electrocardiol · 2023 The ECG diagnosis of LVH is predominantly based on the QRS voltage criteria, i.e. the increased QRS complex amplitude in defined leads. The classical ECG diagnostic paradigm postulates that the increased left ventricular mass generates a stronger electrica ... Full text Link to item Cite

Relation of glycemic status with unrecognized MI and the subsequent risk of mortality: The Jackson Heart Study.

Journal Article Am J Prev Cardiol · September 2022 BACKGROUND: Almost 1/3 to 1/2 of initial myocardial infarctions (MI) may be silent or unrecognized (UMI), which forecasts future clinical events. Further, limited data exist to describe the potential risk for UMI in African-Americans. The relationship of g ... Full text Link to item Cite

Highlights in ASCVD Primary Prevention for 2021.

Journal Article J Am Heart Assoc · July 5, 2022 This review examines key studies published in 2021 that are related to primary prevention of atherosclerotic cardiovascular disease (ASCVD). Major randomized clinical trials (RCTs) concerning traditional risk factors or ASCVD events, meta-analyses, and key ... Full text Link to item Cite

Abnormal Fasting Glucose Increases Risk of Unrecognized Myocardial Infarctions in an Elderly Cohort.

Journal Article J Am Geriatr Soc · January 2019 OBJECTIVES: To investigate glucose levels as a risk factor for unrecognized myocardial infarctions (UMIs). DESIGN: Cohort SETTING: Cardiovascular Health Study. PARTICIPANTS: Individuals aged 65 and older with fasting glucose measurements (N=4,355; normal f ... Full text Link to item Cite

Incident Silent Myocardial Infarction among People with Prediabetes—Results from Four Longitudinal Cohort Studies

Conference Diabetes · July 1, 2018 Approximately 45% of first of myocardial infarctions (MI) are silent. People with diabetes are more likely to have MIs than those without diabetes. Little is known, however, about silent MIs (SMIs) among those with prediabetes. The prognosis of SMI ... Full text Cite

The 4th Report of the Working Group on ECG diagnosis of Left Ventricular Hypertrophy.

Journal Article J Electrocardiol · 2017 The 4th Report provides a brief review of publications focused on the electrocardiographic diagnosis of left ventricular hypertrophy published during the period of 2010 to 2016 by the members of the Working Group on ECG diagnosis of Left Ventricular Hypert ... Full text Link to item Cite

Corrigendum

Journal Article Journal of the American Society of Hypertension · September 2016 Full text Cite

Prediabetes and the association with unrecognized myocardial infarction in the multi-ethnic study of atherosclerosis.

Journal Article Am Heart J · November 2015 BACKGROUND: With one-quarter of initial myocardial infarctions (MI) being unrecognized MI (UMI), recognition is critical to minimize further cardiovascular risk. Diabetes mellitus is an established risk factor for UMI. If impaired fasting glucose (IFG) als ... Full text Link to item Cite

Emerging risk factors as markers for carotid intima media thickness scores.

Journal Article J Am Coll Nutr · 2015 AIMS: Cardiovascular disease (CVD) remains the number one cause of mortality in the Western world. This study aims to determine which lifestyle factors are associated with mean carotid intima media thickness (IMT), a safe and reliable predictor of future C ... Full text Link to item Cite

The role of ECG in the diagnosis of left ventricular hypertrophy.

Journal Article Curr Cardiol Rev · August 2014 The traditional approach to the ECG diagnosis of left ventricular hypertrophy (LVH) is focused on the best estimation of left ventricular mass (LVM) i.e. finding ECG criteria that agree with LVM as detected by imaging. However, it has been consistently rep ... Full text Link to item Cite

Electrocardiographic left ventricular strain pattern: everything old is new again.

Journal Article J Electrocardiol · 2014 Electrocardiographic left ventricular hypertrophy (LVH) has many faces with countless features. Beyond the classic measures of LVH, including QRS voltage and duration, the left ventricular (LV) strain pattern is an element whereby characteristic R-ST depre ... Full text Link to item Cite

Effect of amlodipine on the survival of patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2 study (prospective randomized amlodipine survival evaluation 2).

Journal Article JACC Heart Fail · August 2013 OBJECTIVES: This study was designed to test the hypothesis of whether amlodipine reduces the risk for death in patients with heart failure due to a nonischemic cardiomyopathy. BACKGROUND: A pre-specified subgroup analysis in an earlier, large-scale, placeb ... Full text Link to item Cite

Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study.

Journal Article J Am Coll Cardiol · September 18, 2012 OBJECTIVES: The aim of this study was to assess the efficacy of exercise and antidepressant medication in reducing depressive symptoms and improving cardiovascular biomarkers in depressed patients with coronary heart disease. BACKGROUND: Although there is ... Full text Link to item Cite

The effects of a tailored cardiac rehabilitation program on depressive symptoms in women: A randomized clinical trial.

Journal Article Int J Nurs Stud · January 2011 BACKGROUND: Depression is known to co-occur with coronary heart disease (CHD). Depression may also inhibit the effectiveness of cardiac rehabilitation (CR) programs by decreasing adherence. Higher prevalence of depression in women may place them at increas ... Full text Link to item Cite

Prospective assessment of the occurrence of anemia in patients with heart failure: results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry.

Journal Article Am Heart J · May 2009 BACKGROUND: Although a potentially important pathophysiologic factor in heart failure, the prevalence and predictors of anemia have not been well studied in unselected patients with heart failure. METHODS: The Study of Anemia in a Heart Failure Population ... Full text Link to item Cite

Examining the challenges of recruiting women into a cardiac rehabilitation clinical trial.

Journal Article J Cardiopulm Rehabil Prev · 2009 PURPOSE: To examine the challenges of recruiting women for a 5-year cardiac rehabilitation randomized clinical trial; the aims of the study were to describe the range of recruitment sources, examine the myriad of factors contributing to ineligibility and n ... Full text Link to item Cite

Prevention of heart failure: a scientific statement from the American Heart Association Councils on Epidemiology and Prevention, Clinical Cardiology, Cardiovascular Nursing, and High Blood Pressure Research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group.

Journal Article Circulation · May 13, 2008 The increase in heart failure (HF) rates throughout the developed and developing regions of the world poses enormous challenges for caregivers, researchers, and policymakers. Therefore, prevention of this global scourge deserves high priority. Identifying ... Full text Link to item Cite

Racial/ethnic disparities in mortality related to congenital heart defects among children and adults in the United States.

Journal Article Ethn Dis · 2008 BACKGROUND: Congenital heart defects (CHD) are the most common birth defect and are a major cause of childhood illness and death. Recent progress in management of persons with CHD may have decreased CHD-related mortality. METHODS: Year 2000 US death record ... Link to item Cite

Adverse baseline physiological and psychosocial profiles of women enrolled in a cardiac rehabilitation clinical trial.

Journal Article J Cardiopulm Rehabil Prev · 2008 PURPOSE: Coronary heart disease (CHD) remains the leading cause of death in women. Despite positive outcomes associated with cardiac rehabilitation (CR), investigations of women are sparse. This article presents the baseline physiological and psychosocial ... Full text Link to item Cite

Diabetes-induced bradycardia is an intrinsic metabolic defect reversed by carnitine.

Journal Article Metabolism · August 2007 Rats with streptozotocin-induced diabetes (STZ-D) have reduced serum carnitine levels and bradycardia. Heart rates (HRs) of 24nondiabetic rats (NRs) and 24 STZ-D rats were compared. L-carnitine (C) was added to the drinking water of rats (12 STZ-D+C) to ra ... Full text Link to item Cite

Utility of impedance cardiography for the identification of short-term risk of clinical decompensation in stable patients with chronic heart failure.

Journal Article J Am Coll Cardiol · June 6, 2006 OBJECTIVES: This study sought to assess the potential utility of impedance cardiography (ICG) in predicting clinical deterioration in ambulatory patients with heart failure (HF). BACKGROUND: Impedance cardiography uses changes in thoracic electrical impeda ... Full text Link to item Cite

Blood pressure as a predictor of cardiovascular events in the elderly: the William Hale Research Program.

Journal Article J Hum Hypertens · June 2006 This study evaluates the association between blood pressure (BP) and the risk of developing cardiovascular disease (CVD) events in the elderly. The Morton Plant Mease Foundation has followed 4,008 elderly patients >64 years of age for at least 5 years. Sys ... Full text Link to item Cite

Cardio-protective effects of carnitine in streptozotocin-induced diabetic rats.

Journal Article Cardiovasc Diabetol · January 19, 2006 BACKGROUND: Streptozotocin-induced diabetes (STZ-D) in rats has been associated with carnitine deficiency, bradycardia and left ventricular enlargement. AIM: The purpose of this study was to determine whether oral carnitine supplementation would normalize ... Full text Link to item Cite

Cardio-protective effects of carnitine in streptozotocin-induced diabetic rats

Journal Article Cardiovascular Diabetology · January 19, 2006 Background: Streptozotocin-induced diabetes (STZ-D) in rats has been associated with carnitine deficiency, bradycardia and left ventricular enlargement. Aim: The purpose of this study was to determine whether oral carnitine supplementation would normalize ... Full text Cite

Cardiac tamponade complicating trimodal therapy for malignant mesothelioma.

Journal Article Heart Lung · 2006 Trimodal therapy, which includes extrapleural pneumonectomy as the cytoreductive procedure followed by combination chemoradiotherapy, is becoming the standard of care in the treatment of malignant mesothelioma. We report here a case of hypotension secondar ... Full text Link to item Cite

The past as prologue.

Journal Article Prev Cardiol · 2006 Full text Link to item Cite

Hypertension and heart failure. Roundtable discussion.

Journal Article J Clin Hypertens (Greenwich) · June 2004 Following a symposium on hypertension in Tampa, FL, in February 2004, a roundtable discussion was held to review new data regarding the management of hypertension and heart failure. The discussion was moderated by Dr. Marvin Moser of the Yale University Sc ... Full text Link to item Cite

Combined treatment with vessel dilator and kaliuretic hormone in persons with congestive heart failure.

Journal Article Exp Biol Med (Maywood) · June 2004 Vessel dilator and kaliuretic hormone, two cardiovascular peptide hormones, enhance urine flow 2- to 13-fold and 4-fold, respectively, in persons with class III New York Heart Association congestive heart failure (CHF). The natriuresis and diuresis seconda ... Full text Link to item Cite

Intact negative feedback of four cardiac hormones in congestive heart failure.

Journal Article Metabolism · May 2002 In 30 individuals with class III congestive heart failure (CHF), negative feedback of 4 cardiac peptide hormones, ie, long-acting natriuretic peptide (LANP), vessel dilator, kaliuretic peptide, and atrial natriuretic factor (ANF) from the same 126-amino ac ... Full text Link to item Cite

Atrial natriuretic hormone, vessel dilator, long acting natriuretic hormone, and kaliuretic hormone decrease circulating prolactin concentrations.

Journal Article Horm Metab Res · May 2002 The present investigation was designed to test whether four cardiac hormones--long acting natriuretic hormone, vessel dilator, kaliuretic hormone and atrial natriuretic hormone--decrease the circulating concentration of prolactin in humans (n = 30). Vessel ... Full text Link to item Cite

Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone.

Journal Article Endocrine · March 2002 This study was designed to determine whether four peptide hormones consisting of amino acids 1-30-long-acting natriuretic hormone (LANH), 31-67 (vessel dilator), 79-98 (kaliuretic hormone), and 99-126 (atrial natriuretic hormone [ANH])-of the 126 amino aci ... Full text Link to item Cite

Atrial natriuretic hormone, vessel dilator, long-acting natriuretic hormone, and kaliuretic hormone decrease the circulating concentrations of total and tree T4 and free T3 with reciprocal increase in TSH.

Journal Article J Clin Endocrinol Metab · November 2001 The present investigation was designed to determine whether atrial natriuretic peptides (ANPs) consisting of amino acids 1-30 [i.e. long-acting natriuretic hormone (LANH)], 31-67 (vessel dilator), 79-98 (kaliuretic hormone), and 99-126 (atrial natriuretic ... Full text Link to item Cite

Atrial natriuretic hormone, vessel dilator, long-acting natriuretic hormone, and kaliuretic hormone decrease the circulating concentrations of CRH, corticotropin, and cortisol.

Journal Article J Clin Endocrinol Metab · September 2001 The present investigation was designed to determine whether atrial natriuretic peptides consisting of amino acids 1-30 (i.e. long-acting natriuretic hormone), 31-67 (vessel dilator), 79-98 (kaliuretic hormone), and 99-126 (atrial natriuretic hormone) of th ... Full text Link to item Cite

Effects of kaliuretic peptide on sodium and water excretion in persons with congestive heart failure.

Journal Article Am J Cardiol · July 1, 2001 Kaliuretic peptide, a 20-amino acid peptide hormone synthesized in the heart, enhances urine flow twofold, whereas atrial natriuretic peptide (ANP) enhances urine flow four- to 11-fold in healthy persons. The present investigation was designed to (1) deter ... Full text Link to item Cite

Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide enhance urinary excretion rate of albumin, total protein, and beta(2)-microglobulin in patients with congestive heart failure.

Journal Article J Card Fail · March 2001 BACKGROUND: Albumin excretion is increased in persons with congestive heart failure (CHF), but the mechanism of this increase is unknown. Atrial natriuretic peptide (ANP) does not correlate with this albumin excretion, but the other 3 cardiac hormones deri ... Full text Link to item Cite

Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide enhance the urinary excretion rate of beta2-microglobulin.

Journal Article Metabolism · December 2000 The atrial natriuretic peptide (ANP) gene synthesizes a 126-amino acid (aa) prohormone from which four peptide hormones are derived. These 4 peptide hormones consisting of aa 1 to 30 (ie, long-acting natriuretic peptide [LANP]), aa 31 to 67 (vessel dilator ... Full text Link to item Cite

Epidemiology and risk factors for heart failure in the elderly.

Journal Article Clin Geriatr Med · August 2000 Heart failure is a common problem in the elderly population, affecting 10% or more of persons more than 80 years of age. Heart failure is most likely to develop in the elderly population, with an annual incidence of 20 to 30 cases per 1000 persons aged mor ... Full text Link to item Cite

Vessel dilator, long acting natriuretic peptide, and kaliuretic peptide increase circulating prostaglandin E2.

Journal Article Life Sci · 2000 Prostaglandin E2 (PGE2) increases in the circulation of persons with congestive heart failure (CHF), but the cause of this increase is unknown. Prostaglandins are not stored, therefore, they cannot be released in response to congestive heart failure itself ... Full text Link to item Cite

Comparison of vessel dilator and long-acting natriuretic peptide in the treatment of congestive heart failure.

Journal Article Am Heart J · October 1999 BACKGROUND: Long-acting natriuretic peptide (LANP; proANF 1-30) and vessel dilator (proANF 31-67) enhance sodium and water excretion in healthy human beings. The current investigation was designed to compare the beneficial effects of LANP and vessel dilato ... Full text Link to item Cite

Diabetic cardiomyopathy and carnitine deficiency.

Journal Article J Diabetes Complications · 1999 This study was designed to study the pathogenesis of cardiomyopathy in animals with longstanding (6 months) diabetes mellitus. Male Wistar rats were made diabetic by the injection of streptozotocin (35 mg/kg) intraperitoneal at 6 months of age. Myocardial ... Full text Link to item Cite

Are sleep complaints an independent risk factor for myocardial infarction?

Journal Article Ann Epidemiol · August 1998 PURPOSE: To investigate whether subjective sleep complaints are an independent predictor of myocardial infarction (MI) in a community of older adults and to gain clues as to why the association between sleep complaints and incident MI exists. METHODS: Usin ... Full text Link to item Cite

Vessel dilator enhances sodium and water excretion and has beneficial hemodynamic effects in persons with congestive heart failure.

Journal Article Circulation · July 28, 1998 BACKGROUND: Vessel dilator, a 37-amino acid peptide hormone synthesized in the heart, enhances urine flow 4- to 12-fold and sodium excretion 3- to 6-fold in healthy humans. The present investigation was designed to determine whether vessel dilator might ha ... Full text Link to item Cite

Shortness of breath and edema after heart surgery.

Journal Article Hosp Pract (1995) · July 15, 1998 Full text Link to item Cite

Comparison of habitual runners and anorexia nervosa patients.

Journal Article Int J Eat Disord · March 1998 UNLABELLED: Psychological and physiological similarities have been proposed between habitual runners and anorexia nervosa patients. METHOD: Twenty male runners, 20 female runners, and 17 anorexia nervosa patients were evaluated using several psychological ... Full text Link to item Cite

Atrial natriuretic peptide increases urodilatin in the circulation.

Journal Article Am J Nephrol · 1998 BACKGROUND: Urodilatin is a 32-amino-acid (AA) peptide formed in the kidney. METHODS: High-performance gel permeation chromatography and high-pressure liquid chromatography evaluation of plasma followed by sensitive urodilatin and atrial natriuretic peptid ... Full text Link to item Cite

Foreword

Chapter · 1998 Cite

Adrenomedullin, endothelin, neuropeptide Y, atrial, brain, and C-natriuretic prohormone peptides compared as early heart failure indicators.

Journal Article Cardiovasc Res · November 1997 OBJECTIVES: The present investigation was designed to determine the best endogenous plasma marker of early congestive heart failure (CHF). METHODS: Forty volunteers with mild CHF (New York Heart Association Class I, n = 12), moderate (Class II, n = 8), or ... Full text Link to item Cite

Disposition of vessel dilator and long-acting natriuretic peptide in healthy humans after a one-hour infusion.

Journal Article J Pharmacol Exp Ther · August 1997 The present investigation was designed to determine half-lives, distribution phases and metabolic clearance of two new cardiac peptide hormones in humans. Long-acting natriuretic peptide (LANP) and vessel dilator were infused at 100 ng/kg of b.wt./min conc ... Link to item Cite

Atrial natriuretic peptides increase calcitonin gene-related peptide within human circulation.

Journal Article Metabolism · July 1997 Long-acting natriuretic peptide (LANP), vessel dilator, and atrial natriuretic factor (ANF) (each infused at 100 ng/kg body weight [BW].min for 60 minutes) increased the circulating concentration of calcitonin gene-related peptide (CGRP) threefold to fourf ... Full text Link to item Cite

Role of cytokines in the mechanism of action of amlodipine: the PRAISE Heart Failure Trial. Prospective Randomized Amlodipine Survival Evaluation.

Journal Article J Am Coll Cardiol · July 1997 OBJECTIVES: We sought to determine whether the beneficial effects of amlodipine in heart failure may be mediated by a reduction in tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels. We postulated that TNF-alpha and IL-6 levels may als ... Full text Link to item Cite

Body composition and source of weight loss after bariatric surgery.

Journal Article Obes Surg · June 1997 BACKGROUND: Little is known about the composition and source of weight loss after bariatric surgery for morbid obesity. PURPOSE: This study was undertaken to determine changes in weight, body mass index (BMI), lean body weight (LBW), fat weight (FW) and le ... Full text Link to item Cite

Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans.

Journal Article Metabolism · March 1996 The present investigation was designed to examine the effect of four atrial peptide hormones with vasodilatory properties on the circulating immunoreactive (ir) levels of the vasoconstrictive peptide endothelin (ET) in 36 healthy human subjects. Circulatin ... Full text Link to item Cite

Digoxin restores in vitro but not in vivo response to adrenerghc stimulation in experimental volume overload

Journal Article Journal of Investigative Medicine · January 1, 1996 Digoxin may restore contractile function in volume overload hypertrophy, however the mechanisms are not well understood. To determine the effects of digoxin on the b-receptor system in heart failure, and their effects on in vivo contractile reserve, we ind ... Cite

Atrial natriuretic peptide increases adrenomedullin in the circulation of healthy humans.

Journal Article Life Sci · 1996 Adrenomedullin (ADM) is a new 52 amino acid peptide originally isolated from extracts of human pheochromocytoma. ADM's biologic properties are nearly identical to those of atrial natriuretic peptides. Thus, the 4 peptide hormones originating from amino aci ... Full text Link to item Cite

The role of prolonged thrombolytic infusions and transesophageal echocardiography in thrombosed prosthetic heart valves: case report and review of the literature.

Journal Article Clin Cardiol · November 1995 Thrombolytic therapy for prosthetic heart valve thrombosis has recently been receiving increased attention and is now frequently used an alternative to high-risk surgery. A case is presented describing a novel thrombolytic therapy regimen with emphasis on ... Full text Link to item Cite

Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism.

Journal Article Am J Med Sci · October 1995 Atrial natriuretic factor (ANF), consisting of amino acids 99-126 of the 126 amino acid ANF prohormone, increases cyclic guanosine monophosphate (GMP) (thought to be the mediator of its physiologic effects) in plasma and urine of human subjects. Long-actin ... Full text Link to item Cite

Kaliuretic peptide and long acting natriuretic peptide as well as atrial natriuretic factor inhibit aldosterone secretion.

Journal Article J Endocrinol · September 1995 The present investigation was designed to determine whether atrial natriuretic peptides consisting of amino acids 1-30 (long acting natriuretic peptide), 31-67 (vessel dilator) and 79-98 (kaliuretic peptide) as well as 99-126 (atrial natriuretic factor (AN ... Full text Link to item Cite

Three peptides from the atrial natriuretic factor prohormone amino terminus lower blood pressure and produce diuresis, natriuresis, and/or kaliuresis in humans.

Journal Article Circulation · September 1994 BACKGROUND: Three peptides consisting of amino acids 1-30, 31-67, and 79-98 of the 126-amino acid atrial natriuretic factor prohormone (proANF), which have blood pressure-lowering, diuretic, natriuretic, and/or kaliuretic properties in animals, were invest ... Full text Link to item Cite

Negative feedback of atrial natriuretic peptides.

Journal Article J Clin Endocrinol Metab · May 1994 The present investigation was designed to determine whether atrial natriuretic peptides consisting of amino acids 1-30 [i.e. pro-ANF-(1-30)], 31-67 [i.e. pro-ANF(31-67)], 79-98 [i.e. pro-ANF-(79-98)], and 99-126 [i.e. atrial natriuretic factor (ANF)] of 12 ... Full text Link to item Cite

Transverse shape characteristics of cardiac myocytes from rats and humans.

Journal Article Cardioscience · March 1994 The shape of the cardiac myocyte is complex; but, in general, it resembles that of an elliptical cylinder. Quantitative data, however, are lacking and adaptive changes in cross-sectional shape are unknown. The major and minor transverse diameters of myocyt ... Link to item Cite

Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy.

Journal Article Circulation · August 1992 BACKGROUND: Chronic ischemic heart disease may lead to ventricular dilation and congestive heart failure (ischemic cardiomyopathy [ICM]). The changes in cardiac myocyte shape associated with this dilation, however, are not known. METHODS AND RESULTS: Left ... Full text Link to item Cite

Prevalence and mortality rate of congestive heart failure in the United States.

Journal Article J Am Coll Cardiol · August 1992 OBJECTIVES: The study was designed to determine the prevalence and mortality rate of congestive heart failure in noninstitutionalized men and women in the U.S. BACKGROUND: Congestive heart failure is a serious condition with significant morbidity and morta ... Full text Link to item Cite

Florida's response to the Physician's National Cholesterol Education Program.

Journal Article J Fla Med Assoc · February 1992 To assess the impact of the National Cholesterol Education Program (NCEP) guidelines, the 7,347 primary care members of the Florida Medical Association received a confidential mailed questionnaire. A follow-up survey polling 5% of the nonresponders validat ... Link to item Cite

Comparative drug effects in hypertensive women over 65

Journal Article Cardiology Board Review · January 1, 1992 Cite

Self-report of chest pain symptoms and coronary artery disease in patients undergoing angiography.

Journal Article Pain · December 1991 The relation of self-reported chest discomfort to the presence of atherosclerosis was examined, taking age and gender differences into account. Sixteen practicing cardiologists independently rated the items of a self-report questionnaire of angina pectoris ... Full text Link to item Cite

A randomized controlled trial of the effects of three antihypertensive agents on blood pressure control and quality of life in older women.

Journal Article Arch Intern Med · September 1991 We conducted a multicenter, randomized, double-blind, parallel group trial to compare the impact of titrated doses of atenolol (50 to 100 mg once a day), enalapril (5 to 20 mg once a day), and diltiazem (sustained release) (60 to 180 mg twice a day) on blo ... Link to item Cite

Cardiac function during weight restoration in anorexia nervosa

Journal Article International Journal of Eating Disorders · January 1, 1991 Fifteen anorexia nervosa patients were evaluated on hospitalization at their lowest weights; 10 were restudied after 25% of their weight deficit had been restored and five at 75% weight restoration. Cardiac function improved with weight gain, but different ... Full text Cite

Update on sick sinus syndrome, a cardiac disorder of aging.

Journal Article Geriatrics · January 1990 Sick sinus syndrome (SSS) is usually a disease of the elderly produced by idiopathic degeneration of the sinoatrial node. Its initial manifestations range from asymptomatic to nonspecific and include palpitations, fatigue, confusion, and even syncope and s ... Link to item Cite

Weight loss and the heart. Effects of anorexia nervosa and starvation.

Journal Article Arch Intern Med · April 1989 Anorexia nervosa is a common psychiatric disorder predominantly affecting young women, associated with significant morbidity and mortality, much involving the cardiovascular system. In contrast, protein-calorie malnutrition, while not strictly analogous to ... Link to item Cite

CASS in retrospect: lessons from the randomized cohort and registry. Coronary Artery Surgery Study.

Journal Article Am J Med Sci · May 1988 The Coronary Artery Surgery Study (CASS) was a prospective, randomized evaluation of the value of coronary artery bypass grafting compared with medical therapy for stable, mildly symptomatic coronary artery disease. Also, the CASS registry collected clinic ... Full text Link to item Cite

Effects of age and gender on the relationship between anxiety and coronary artery disease.

Journal Article Psychosom Med · 1987 This study investigated the relationship between anxiety and coronary artery disease (CAD). State (S-ANX) and trait (T-ANX) anxiety were assessed with the State-Trait Personality Inventory (STPI), which was administered to 373 patients (230 males, 143 fema ... Full text Link to item Cite

Digitalis use in a retirement community.

Journal Article J Am Geriatr Soc · July 1986 Complex medical problems of older patients demand that particular care be taken with their use of digitalis. Although accounting for more than 5% of the top ten prescribed drugs in the United States, studies have suggested that digitalis use might be disco ... Full text Link to item Cite

Use of multiple radioligands to characterize adenosine receptors in human placenta.

Journal Article Placenta · 1986 To identify and characterize fully the adenosine receptor of human placenta, particulate preparations of placental parenchyma were examined using several adenosine receptor ligands, [3H]2-chloradenosine ([3H]2-Cl-ADO), [3H]N6-ethylcarboxamideadenosine ([3H ... Full text Link to item Cite

Evaluation of a QRS scoring system for estimating myocardial infarct size. V. Specificity and method of application of the complete system.

Journal Article Am J Cardiol · June 1, 1985 The specificity of a previously developed 57-criteria/32-point QRS scoring system for estimating myocardial infarct (MI) size is evaluated in an extensive control population and the method of application of this system for determining a QRS score from a st ... Full text Link to item Cite

Non-Q wave myocardial infarction. Pathophysiology and prognostic implications.

Journal Article Chest · December 1984 Non-Q wave myocardial infarctions, also known as nontransmural myocardial infarctions or subendocardial myocardial infarctions, have been managed as "mild" coronary events in the past. Substantial evidence now requires modification of this approach. Becaus ... Full text Link to item Cite

Sudden death in cancer patients receiving lithium.

Journal Article J Clin Oncol · November 1984 Lithium carbonate may attenuate the incidence and severity of infection associated with cancer chemotherapy but does not appear to improve patient survival. Of 100 patients with small-cell lung cancer receiving an identical regimen of cyclophosphamide, dox ... Full text Link to item Cite

Congestive heart failure: Dx and Rx in the elderly.

Journal Article Geriatrics · November 1984 Ventricular gallop is a reliable indicator of poor ventricular compliance and heart failure in the elderly. Late diastolic atrial gallop, however, has very little use in the diagnosis of heart disease in the elderly. M-mode and 2-dimensional echocardiograp ... Link to item Cite

Prognostic value of radionuclide exercise testing after myocardial infarction.

Journal Article Cardiol Clin · August 1984 Abnormal systolic ventricular function and persistent ischemia are sensitive indicators of poor prognosis following myocardial infarction. The use of exercise improves the utility of both radionuclide ventriculography and myocardial perfusion scintigraphy ... Link to item Cite

Physical conditioning and left ventricular performance in the elderly: assessment by radionuclide angiocardiography.

Journal Article Am J Cardiol · August 1983 In contrast to young persons, normal elderly persons who undergo symptom-limited dynamic exercise demonstrate a decrease in left ventricular (LV) contractile performance characterized by a decrease in LV ejection fraction. To test the hypothesis that physi ... Full text Link to item Cite

Longitudinal changes in serum cholesterol in man: an epidemiologic search for an etiology.

Journal Article J Chronic Dis · February 1982 Serum cholesterol levels were determined in 1011 male participants of the Baltimore Longitudinal Study of Aging. This study presents the longitudinal changes in serum cholesterol from 1 July 1963 to 30 June 1977. Serum cholesterol values dropped 6% between ... Full text Link to item Cite

Psychological and physiological effects of physical conditioning on the elderly.

Journal Article J Psychosom Res · 1982 A decline in cardiovascular functioning is generally thought to occur with advancing age. The purpose of the present study was to assess the effects of regular aerobic exercise on a group of 24 young-old (65-69) and old-old (70-85 yr) volunteers. Comprehen ... Full text Link to item Cite

Adrenergic receptors of the placenta

Journal Article Trends in Pharmacological Sciences · January 1, 1982 Full text Cite

Medical aspects of competitive distance running: guidelines for community physicians.

Journal Article Postgrad Med · July 1981 While the incidence of major medical emergencies during competitive distance running is low, the large and growing number of persons involved, including the elderly, mandates serious attention by the medical community to provision of adequate prevention an ... Full text Link to item Cite

The human placenta--a rich source of beta-adrenergic receptors: characterization of the receptors in particulate and solubilized preparations.

Journal Article J Clin Endocrinol Metab · June 1980 A crude particulate fraction of human placenta possesses a high concentration of beta-adrenergic receptors, as determined by (-)-[3H]dihydroalprenolol binding (approximately 240 fmol/mg protein; Kd approximately 2 nM). The sites display all the typical cha ... Full text Link to item Cite

Obstructive nephropathy in the rat: possible roles for the renin-angiotensin system, prostaglandins, and thromboxanes in postobstructive renal function.

Journal Article J Clin Invest · February 1980 Relief of unilateral ureteral obstruction (UUO) of 24 h duration in rats is followed by severe renal vasoconstriction in the postobstructive kidney (POK). The present study examined possible roles of renal prostaglandins (PG) and thromboxanes (TX), as well ... Full text Link to item Cite

Loss of beta adrenergic receptors from human lymphocytes during aging

Journal Article Clinical Research · January 1, 1977 Cite

Post-obstructive diuresis: a varied syndrome.

Journal Article J Urol · February 1975 A prospective study was undertaken to define the clinical features, natural history and etiology of post-obstructive diuresis. Studied in detail were 8 patients with a massive diuresis after relief of urinary tract obstruction. We found that urea mediated ... Full text Link to item Cite