Scholars@Duke
Edward Po-Chung Chen

Selected Publications

Valve-sparing aortic root replacement versus composite valve graft with bioprosthesis in patients under age 50.

Journal Article J Thorac Cardiovasc Surg · October 2024 BACKGROUND: Although the unique risks of implanting a prosthetic valve after aortic valve (AV) surgery in young patients are well established, studies of aortic root replacement (ARR) are lacking. We investigated long-term outcomes after valve-sparing root ... Full text Link to item Cite

Valve-sparing root replacement versus composite valve graft root replacement: Analysis of more than 1500 patients from 2 aortic centers.

Journal Article J Thorac Cardiovasc Surg · September 2024 OBJECTIVES: The long-term outcomes comparing valve-sparing root replacement, composite valve graft with bioprosthesis, and mechanical prosthesis have yet to be explored. We investigated the long-term survival and reintervention rates after 1 of 3 major aor ... Full text Link to item Cite

Total aortic arch replacement using a frozen elephant trunk device: Results of a 1-year US multicenter trial.

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVE: In this prospective US investigational device exemption trial, we assessed the safety and 1-year clinical outcomes of the Thoraflex Hybrid device (Terumo Aortic) for the frozen elephant trunk technique to repair the ascending aorta, aortic arch, ... Full text Link to item Cite

Acute-on-Chronic Aortic Dissection: Management and Outcomes of the Unstable "Triple-Lumen" Aorta.

Conference The Annals of thoracic surgery · May 2024 BackgroundThe impact of acute aortic dissection of the chronically dissected distal aorta is unknown. This study sought to describe the incidence and characteristics of the triple-lumen aortic dissection and its impact on survival.Methods ... Full text Cite

Reintervention after valve-sparing aortic root replacement: A comprehensive analysis of 781 David V procedures.

Conference J Thorac Cardiovasc Surg · April 2024 OBJECTIVE: Studies of reintervention after valve-sparing aortic root replacement (VSRR) are limited by sample size and failure to evaluate all types of reinterventions, including distal aorta and transcatheter interventions. In this report, reintervention ... Full text Link to item Cite

Acute type A aortic syndromes: outcomes are independent of aortic root/valve management

Journal Article Indian Journal of Thoracic and Cardiovascular Surgery · March 1, 2024 Purpose: Clinical outcomes following various surgical intervention strategies for aortic root and valve pathology during repair of acute type A aortic syndromes were studied and compared. Methods: From 2004 to 2019, 634 patients underwent acute type A aort ... Full text Cite

Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest Trial (GOT ICE): A Randomized Clinical Trial Comparing Outcomes After Aortic Arch Surgery.

Journal Article Circulation · February 27, 2024 BACKGROUND: Deep hypothermia has been the standard for hypothermic circulatory arrest (HCA) during aortic arch surgery. However, centers worldwide have shifted toward lesser hypothermia with antegrade cerebral perfusion. This has been supported by retrospe ... Full text Link to item Cite

The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement.

Journal Article J Thorac Cardiovasc Surg · February 2024 OBJECTIVE: The effects of stroke and delirium on postdischarge cognition and patient-centered health outcomes after surgical aortic valve replacement (SAVR) are not well characterized. Here, we assess the impact of postoperative stroke and delirium on thes ... Full text Link to item Cite

Neurological event rates and associated risk factors in acute type B aortic dissections treated by thoracic aortic endovascular repair.

Journal Article J Thorac Cardiovasc Surg · January 2024 OBJECTIVES: Thoracic endovascular aortic repair is the method of choice in patients with complicated type B acute aortic dissection. However, thoracic endovascular aortic repair carries a risk of periprocedural neurological events including stroke and spin ... Full text Link to item Cite

Evidence-based frozen elephant trunk practice: a narrative review.

Journal Article Cardiovasc Diagn Ther · December 15, 2023 BACKGROUND AND OBJECTIVE: The frozen elephant trunk (FET) allows a single-stage repair of complex arch pathologies due to its stented and non-stented hybrid prosthesis (HP) features. FET inherently has its own related complications including distal stent g ... Full text Link to item Cite

Editor's Choice - Trends in Management and Outcomes of Type B Aortic Dissection: A Report From the International Registry of Aortic Dissection.

Journal Article Eur J Vasc Endovasc Surg · December 2023 OBJECTIVE: To describe the trends in management and outcomes of patients with acute type B aortic dissection in the International Registry of Acute Aortic Dissection. METHODS: From 1996 - 2022, 3 908 patients were divided into similar sized quartiles (T1, ... Full text Link to item Cite

Aortic valve-sparing operations: my perspectives

Journal Article Indian Journal of Thoracic and Cardiovascular Surgery · December 1, 2023 Valve-sparing procedures have been established as a durable option for treatment of patients with aortic root pathology. Complex cases where aortic valve-sparing root replacement (VSRR) is applied require specific surgical techniques to ensure good outcome ... Full text Cite

True redo-aortic root replacement versus root replacement after any previous surgery

Journal Article JTCVS Open · December 1, 2023 Objective: The impact of previous aortic root replacement (True-Redo) versus any previous operation (Any-Redo) on outcomes after reoperative aortic root replacement (redo-ROOT) is largely unknown. In this first multi-institutional study, the clinical impac ... Full text Cite

Redo aortic surgery: Does one versus multiple affect outcomes?

Journal Article JTCVS Open · December 1, 2023 Objective: Redo aortic surgery has a higher risk of morbidity and mortality because it is technically complex due to mediastinal adhesions, infection, and previously implanted prostheses. In this study, we sought to benchmark our single-center experience c ... Full text Cite

2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.

Journal Article J Thorac Cardiovasc Surg · November 2023 AIM: The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term ... Full text Link to item Cite

Reoperative aortic root replacement for prosthetic aortic valve endocarditis: impact of aortic graft.

Journal Article Eur J Cardiothorac Surg · October 4, 2023 OBJECTIVES: Existing aortic graft complicates the surgical management of prosthetic valve endocarditis (PVE); yet, its impact has not been well studied. We compared outcomes of patients with prior aortic valve replacement (AVR) versus aortic surgery plus A ... Full text Link to item Cite

Thoraflex Hybrid vs. AMDS: To replace the arch or to stent it in type A aortic dissection?

Journal Article Asian Cardiovasc Thorac Ann · September 2023 BACKGROUND: Acute type A aortic dissection (ATAAD) is a life-threatening medical emergency that requires urgent surgical intervention. The mainstay surgical approach to treating ATAAD with aortic arch involvement is total arch replacement (TAR). The frozen ... Full text Link to item Cite

Myths and methodologies: Cardiopulmonary exercise testing for surgical risk stratification in patients with an abdominal aortic aneurysm; balancing risk over benefit.

Journal Article Exp Physiol · September 2023 The extent to which patients with an abdominal aortic aneurysm (AAA) should exercise remains unclear, given theoretical concerns over the perceived risk of blood pressure-induced rupture, which is often catastrophic. This is especially pertinent during car ... Full text Link to item Cite

Uncomplicated Type B Aortic Dissection: Challenges in Diagnosis and Categorization.

Journal Article Annals of vascular surgery · August 2023 BackgroundAcute type B aortic dissection (TBAD) is a rare disease that is likely under-diagnosed in the UK. As a progressive, dynamic clinical entity, many patients initially diagnosed with uncomplicated TBAD deteriorate, developing end-organ malp ... Full text Cite

Bentall versus valve-sparing aortic root replacement for root pathology with moderate-to-severe aortic insufficiency: a propensity-matched analysis.

Journal Article Eur J Cardiothorac Surg · August 1, 2023 OBJECTIVES: To examine short- and long-term outcomes of patients with moderate-to-severe aortic insufficiency (AI) undergoing either a Bentall aortic root replacement (ARR) or valve-sparing root replacement (VSRR). METHODS: A two-centre retrospective datab ... Full text Link to item Cite

Frozen elephant trunk: the gold standard.

Journal Article Cardiovasc Diagn Ther · June 30, 2023 Full text Link to item Cite

Understanding and Managing Direct Operating Room Supply Costs in Cardiac Surgery.

Journal Article Ann Thorac Surg · June 2023 BACKGROUND: Value-based bundles require surgeons to understand their costs. Current approaches to cost reporting are confusing and difficult to reproduce. Using the Epic surgical receipt function, we describe an intuitive and systematic approach for evalua ... Full text Link to item Cite

Valve Sparing Root Replacement in Bicuspid Aortic Valve Disease

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · June 1, 2023 A dysfunctional bicuspid aortic valve (BAV) with associated an aortic root aneurysm represents complex pathology with multiple options for surgical repair. Traditionally Bentall aortic root replacement has been the gold standard to ensure a properly functi ... Full text Cite

Valve-sparing root replacement-reimplantation technique.

Journal Article Ann Cardiothorac Surg · May 31, 2023 The first valve sparing root replacement (VSRR) was first described over thirty years ago. Reimplantation is favored at our institution to provide maximum annular support in the setting of annuloaortic ectasia. Multiple iterations for this operation have b ... Full text Link to item Cite

Optimal circulatory arrest temperature for aortic hemiarch replacement with antegrade brain perfusion.

Conference J Thorac Cardiovasc Surg · May 2023 OBJECTIVE: This study sought to identify the optimal temperature for moderate hypothermic circulatory arrest in patients undergoing elective hemiarch replacement with antegrade brain perfusion. METHODS: The Society of Thoracic Surgeons adult cardiac surger ... Full text Link to item Cite

Bicuspid aortic valve durability with valve-sparing aortic root replacement: comparison to tricuspid valve.

Journal Article European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · April 2023 ObjectivesOutcomes beyond 10 years for David V valve-sparing aortic root replacement (VSARR) in bicuspid aortic valve (BAV) patients have yet to be explored. We investigated long-term outcomes after BAV VSARR compared to VSARR for tricuspid aortic ... Full text Cite

Prolonged Periods of Antegrade Cerebral Perfusion Are Safe During Elective Arch Surgery.

Conference Ann Thorac Surg · February 2023 BACKGROUND: Cerebral circulatory arrest times >40 minutes during aortic surgery have previously been shown to be associated with increased morbidity and mortality. The purpose of this study was to redefine what would constitute a safe period of circulatory ... Full text Link to item Cite

Commentary: Wrapping the Ross could prevent its loss!

Journal Article J Thorac Cardiovasc Surg · January 2023 Full text Link to item Cite

Early Results of Thoracic Endovascular Aortic Repair for the Management of Acute Uncomplicated Type B Aortic Dissection.

Journal Article Semin Thorac Cardiovasc Surg · 2023 Historically, optimal medical therapy (OMT) has been the primary therapy for acute uncomplicated type B aortic dissection (auTBAD). However, recent data suggest that OMT provides poor long-term results, and aortic remodeling induced by thoracic endovascula ... Full text Link to item Cite

Frozen elephant trunk: the gold standard

Journal Article Cardiovascular Diagnosis and Therapy · January 1, 2023 Full text Cite

2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.

Journal Article Circulation · December 13, 2022 AIM: The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term ... Full text Link to item Cite

2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

Journal Article Journal of the American College of Cardiology · December 13, 2022 Aim: The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term ... Full text Cite

Cardiothoracic surgery leadership and learning are indispensable to each other.

Journal Article J Card Surg · December 2022 Cardiothoracic surgery is facing a multitude of challenges in leadership and training on the global scale, these being a complex and aging patient population, shortage of cardiac surgeons, diminishing student interest and trainee enthusiasm, increasingly c ... Full text Link to item Cite

Registry of Aortic Diseases to Model Adverse Events and Progression (ROADMAP) in Uncomplicated Type B Aortic Dissection: Study Design and Rationale.

Journal Article Radiol Cardiothorac Imaging · December 2022 PURPOSE: To describe the design and methodological approach of a multicenter, retrospective study to externally validate a clinical and imaging-based model for predicting the risk of late adverse events in patients with initially uncomplicated type B aorti ... Full text Link to item Cite

Clinical Outcomes Using Freestyle Valve-Valsalva Graft Composite Conduit for Aortic Root Replacement.

Conference Ann Thorac Surg · September 2022 BACKGROUND: We reviewed the clinical outcomes of a novel method of aortic root replacement using a self-constructed tissue valve conduit composed of a Freestyle subcoronary valve sewn into a Valsalva graft. METHODS: From 2005 to 2020, 523 patients had aort ... Full text Link to item Cite

Aortic Arch Management During Acute and Subacute Type A Aortic Syndromes.

Conference Ann Thorac Surg · September 2022 BACKGROUND: The purpose of this study was to compare the outcomes of no arch intervention, hemiarch replacement, and total arch replacement during type A aortic syndromes in a contemporary series. METHODS: From 2004 to 2019, 634 patients have required acut ... Full text Link to item Cite

The misnomer of uncomplicated type B aortic dissection.

Journal Article J Card Surg · September 2022 BACKGROUND: Acute type B aortic dissection (TBAD) is a rare condition that can be divided into complicated (CoTBAD) and uncomplicated (UnCoTBAD) based on certain presenting clinical and radiological features, with UnCoTBAD constituting the majority of TBAD ... Full text Link to item Cite

Open arch surgery in the redo setting: contemporary outcomes.

Journal Article J Cardiovasc Surg (Torino) · August 2022 BACKGROUND: Aortic arch reconstruction after prior cardiac surgery is technically complex, especially after proximal aortic surgery. While multiple surgical adaptations in the redo setting have been described, traditional open reconstruction remains the mo ... Full text Link to item Cite

Challenging surgical management of failed freestyle stentless porcine valve: two case reports

Journal Article Journal of Visualized Surgery · July 20, 2022 The Freestyle Stentless Porcine Valve (Medtronic, Fridley, MN, USA) has excellent hemodynamics and can be implanted as either an isolated aortic valve replacement (AVR) or full aortic root replacement. It has excellent durability with documented 15-year fr ... Full text Cite

Duration of deep hypothermic circulatory arrest for aortic arch surgery: is it a myth, fiction, or scientific leap?

Journal Article J Cardiovasc Surg (Torino) · June 2022 INTRODUCTION: The use of deep hypothermic circulatory arrest (DHCA) to provide aortic surgeons with a bloodless operative field while simultaneously protecting the brain and peripheries from ischemic damage revolutionized cardiac and aortic surgery, and is ... Full text Link to item Cite

Frontiers in aortic arch surgery: partem futuri!

Journal Article J Cardiovasc Surg (Torino) · June 2022 Full text Link to item Cite

Protocol Compliance Guiding Angiotensin II Use in Post Cardiovascular Surgery Vasoplegia

Journal Article Critical Care Explorations · May 13, 2022 OBJECTIVES: Catecholamines and vasopressin are commonly used in patients with post cardiovascular surgery vasoplegia (PCSV). Multimodal therapy, including methylene blue (MB), hydroxocobalamin, and angiotensin II (Ang II), may improve outcomes in patients ... Full text Cite

Optimal brain protection in aortic arch surgery.

Journal Article Indian J Thorac Cardiovasc Surg · April 2022 There is considerable debate with regard to the optimal cerebral protection strategy during aortic arch surgery. There are three contemporary techniques in use which include straight deep hypothermic circulatory arrest (DHCA), DHCA with retrograde cerebral ... Full text Link to item Cite

Commentary: Don't forget to re-SAVR the moment.

Journal Article J Thorac Cardiovasc Surg · March 2022 Full text Link to item Cite

Management of brain malperfusion in acute type A aortic dissection.

Journal Article Asian Cardiovasc Thorac Ann · March 2022 This review discusses the management of acute Type A aortic dissection (ATAAD) complicated by cerebral malperfusion (CMP). While prompt surgical repair is the accepted standard of care for ATAAD, there remains uncertainty and debate about the optimal manag ... Full text Link to item Cite

Commentary: Dissecting Out the Root of the Matter.

Journal Article Semin Thorac Cardiovasc Surg · 2022 Full text Link to item Cite

Re-Operative Aortic Arch Surgery in a Contemporary Series.

Conference Semin Thorac Cardiovasc Surg · 2022 Re-operative aortic arch operations (REDO) following previous cardiac surgery are challenging procedures associated with significant morbidity and mortality. We investigated post-operative outcomes for patients undergoing REDO and identified risk-factors f ... Full text Link to item Cite

Surgical features of malignant cardiac tumors

Chapter · January 1, 2022 Malignant primary cardiac tumors are rare and generally present at a young age. Multimodal imaging (CT, Cardiac MRI, and Echo) represents the current gold standard for diagnosis, staging, and surgical planning. Unique considerations include tumor involveme ... Full text Cite

Malperfusion syndromes in acute type A aortic dissection

Journal Article Vessel Plus · January 1, 2022 Acute aortic dissection complicated by malperfusion syndrome is a devastating condition that significantly impacts morbidity and mortality. Malperfusion syndrome can affect any vascular bed with varying degrees of end-organ involvement. While conventional ... Full text Cite

Fifteen Years of Aortic Valve-sparing Root Replacement and Impact of Eccentric Jets on Late Outcomes.

Journal Article Ann Thorac Surg · December 2021 BACKGROUND: Valve-sparing root replacement is more challenging with eccentric aortic insufficiency due to cusp and root asymmetry, which may impact valve durability and survival. This study analyzed the effect of jet eccentricity on long-term outcomes in t ... Full text Link to item Cite

Commentary: Show me the data.

Journal Article J Thorac Cardiovasc Surg · August 2021 Full text Link to item Cite

Priorities in coronary artery bypass grafting: Is midterm survival more dependent on completeness of revascularization or multiple arterial grafts?

Conference J Thorac Cardiovasc Surg · June 2021 OBJECTIVE: Both completeness of revascularization and multiple arterial grafts (multiple arterial coronary artery bypass grafting) have been associated with increased midterm survival after coronary artery bypass grafting. The purpose of this study was to ... Full text Link to item Cite

Benchmarking Outcomes: Reoperation for Aortic Valve Patient-Prosthesis Mismatch.

Conference Ann Thorac Surg · May 2021 BACKGROUND: Surgical reoperations for symptomatic aortic valve patient-prosthesis mismatch (PPM) are complex. The purpose of this research was to investigate the clinical and echocardiographic outcomes of patients who underwent reoperation for correction o ... Full text Link to item Cite

Preoperative Eccentric Aortic Regurgitation and Outcomes Following Valve-Sparing Root Replacement.

Journal Article Semin Thorac Cardiovasc Surg · 2021 The David V valve-sparing root replacement (VSRR) is well-established for the treatment of aortic insufficiency (AI) and advanced root aortopathy. The impact of cusp repair in trileaflet aortic valve (TAV) patients, however, with preoperative moderate-seve ... Full text Link to item Cite

Valve Sparing Aortic Root Replacement for Aortic Valve Insufficiency in Type A Aortic Dissection

Chapter · January 1, 2021 Aortic root replacement is a well-established option for addressing aortic root pathology in Type A acute aortic dissection (TAAAD). When aortic root replacement is performed, surgical options include a composite valve conduit or valve sparing root replace ... Full text Cite

Interrupted Aortic Arch in a Patient with Patient-Prosthesis Mismatch after Aortic Valve Replacement

Journal Article AORTA · October 1, 2019 This case presents a patient who underwent aortic valve replacement and presented 13 years later with high gradients across the prosthesis, mitral insufficiency, and severe systemic hypertension. Her preoperative workup led to the diagnosis of an interrupt ... Full text Cite

Doctor, what would you have done if you were in my place?

Journal Article Shanghai Chest · March 1, 2019 Full text Cite

Thoracic Aortic Surgery in the 21st Century.

Journal Article Semin Thorac Cardiovasc Surg · 2019 Full text Link to item Cite

Size matters: How low should we go?

Journal Article J Thorac Cardiovasc Surg · January 2019 Full text Link to item Cite

Salvage Coronary Artery Bypass Predicts Increased Mortality During Aortic Root Operation.

Journal Article Ann Thorac Surg · December 2018 BACKGROUND: Aortic root replacement (ROOT) has been an established therapy, yet the impact of adding coronary artery bypass grafting (CABG) to ROOT (CABG-R) is unknown. The purpose of this research was to investigate the impact of CABG on the outcomes of R ... Full text Link to item Cite

Safety of Moderate Hypothermia With Antegrade Cerebral Perfusion in Total Aortic Arch Replacement.

Journal Article Ann Thorac Surg · January 2018 BACKGROUND: Total aortic arch replacement (TOTAL) is a complicated operation and has traditionally required deep hypothermic circulatory arrest. In this study, the impact of moderate hypothermic circulatory arrest (MHCA) and antegrade cerebral perfusion (A ... Full text Link to item Cite

Hypothermia and cerebral protection strategies in aortic arch surgery: a comparative effectiveness analysis from the STS Adult Cardiac Surgery Database.

Journal Article Eur J Cardiothorac Surg · September 1, 2017 OBJECTIVES: Hypothermic circulatory arrest is essential to aortic arch surgery, although consensus regarding optimal cerebral protection strategy remains lacking. We evaluated the current use and comparative effectiveness of hypothermia/cerebral perfusion ... Full text Link to item Cite

Reoperative aortic root replacement: Outcome in a contemporary series.

Journal Article J Thorac Cardiovasc Surg · September 2017 OBJECTIVES: Reoperative aortic root replacement is a challenging procedure associated with significant mortality and morbidity. The purpose of this study was to investigate the outcomes of reoperative aortic root replacement when performed in a number of c ... Full text Link to item Cite

The Racial Paradox in Multiarterial Conduit Utilization for Coronary Artery Bypass Grafting.

Journal Article Ann Thorac Surg · April 2017 BACKGROUND: It has been established that outcomes for black patients undergoing coronary artery bypass graft surgery (CABG) are inferior to those of their white counterparts. The purpose of this study was to determine (1) whether rates of multiarterial gra ... Full text Link to item Cite

Should We Perform Carotid Doppler Screening Before Surgical or Transcatheter Aortic Valve Replacement?

Conference Ann Thorac Surg · March 2017 BACKGROUND: Screening for internal carotid artery stenosis (ICAS) with Doppler ultrasound is commonly used before cardiovascular surgery. Nevertheless, the relationship between ICAS and procedure-related stroke in isolated aortic valve replacement is uncle ... Full text Link to item Cite

Predicted Risk of Mortality, Transfusion, and Postoperative Outcomes in Isolated Primary Valve Operations.

Journal Article Ann Thorac Surg · February 2016 BACKGROUND: Transfusion has been linked with increased postoperative morbidity and death after cardiac operations. The purpose of this study was to determine the associations among The Society of Thoracic Surgeons Predicted Risk of Mortality (PROM), transf ... Full text Link to item Cite

Transapical Thoracic Endovascular Aortic Repair as a Bridge to Open Repair of an Infected Ascending Aortic Pseudoaneurysm.

Journal Article Ann Thorac Surg · November 2015 Pseudoaneurysms of the ascending aorta pose a significant risk for free rupture during open aortic repair. This report describes the use of a modified thoracic aortic stent graft, delivered through transapical access, as a successful bridge to homograft re ... Full text Link to item Cite

Moderate Versus Deep Hypothermia With Unilateral Selective Antegrade Cerebral Perfusion for Acute Type A Dissection.

Conference Ann Thorac Surg · November 2015 BACKGROUND: Despite improved results with surgical therapy for acute type A aortic dissection (ATAAD), there remains a lack of consensus regarding the optimal method of cerebral protection and circulation management during ATAAD. The purpose of this study ... Full text Link to item Cite

Discussion

Other Annals of Thoracic Surgery · August 1, 2015 Full text Cite

Avoiding aortic clamping during coronary artery bypass grafting reduces postoperative stroke.

Journal Article J Thorac Cardiovasc Surg · January 2015 OBJECTIVE: The purpose of this study was to determine whether the incidence of postoperative stroke could be reduced by eliminating aortic clamping during coronary artery bypass grafting. METHODS: From 2002 to 2013, 12,079 patients underwent primary, isola ... Full text Link to item Cite

Outcomes in malperfusion syndromes associated with complicated acute Type A aortic dissection

Conference Journal of the American College of Surgeons · October 2014 Full text Cite

Transcatheter aortic valve replacement has improved short-term but similar midterm outcomes in isolated aortic valve replacement after prior coronary artery bypass grafting.

Conference Ann Thorac Surg · October 2014 BACKGROUND: An increasing number of patients with prior coronary artery bypass grafting (CABG) now present with severe aortic stenosis. The proposed benefit of surgical (SAVR) vs transcatheter aortic valve replacement (TAVR) is unknown. The objective of th ... Full text Link to item Cite

Incidence of postoperative stroke using the Heartstring device in 1,380 coronary artery bypass graft patients with mild to severe atherosclerosis of the ascending aorta.

Conference Ann Thorac Surg · June 2014 BACKGROUND: Atherosclerotic disease of the ascending aorta during coronary artery bypass graft surgery (CABG) increases the risk for postoperative stroke. The objective of this study was to examine the incidence of postoperative stroke in CABG utilizing th ... Full text Link to item Cite

The ARCH Projects: design and rationale (IAASSG 001).

Journal Article Eur J Cardiothorac Surg · January 2014 OBJECTIVE: A number of factors limit the effectiveness of current aortic arch studies in assessing optimal neuroprotection strategies, including insufficient patient numbers, heterogenous definitions of clinical variables, multiple technical strategies, in ... Full text Link to item Cite

Acute type a dissection: impact of antegrade cerebral perfusion under moderate hypothermia.

Conference Ann Thorac Surg · December 2013 BACKGROUND: The optimal method of arterial cannulation and circulation management for acute type A aortic dissection (type A) remains debated. Moderate hypothermic circulatory arrest (MHCA) and unilateral selective antegrade cerebral perfusion (uSACP) is e ... Full text Link to item Cite

Impact of preoperative chronic lung disease on survival after surgical aortic valve replacement.

Journal Article Ann Thorac Surg · October 2013 BACKGROUND: An increasing number of patients requiring surgical aortic valve replacement (SAVR) present with chronic pulmonary obstructive disease (COPD). The purpose of this study was to compare patients who had a range of COPD from normal to severe and w ... Full text Link to item Cite

The impact of specific preoperative organ dysfunction in patients undergoing aortic valve replacement.

Conference Ann Thorac Surg · March 2013 BACKGROUND: Optimizing treatment strategies to risk profile patients undergoing aortic valve replacement remains a priority. The role that specific and combinations of preoperative organ dysfunction (OD) plays in informing these decisions remains uncertain ... Full text Link to item Cite

Contemporary results for proximal aortic replacement in North America.

Journal Article J Am Coll Cardiol · September 25, 2012 OBJECTIVES: The purpose of this study was to characterize operative outcomes for ascending aorta and arch replacement on a national scale and to develop risk models for mortality and major morbidity. BACKGROUND: Contemporary outcomes for ascending aorta an ... Full text Link to item Cite

Outcomes following redo sternotomy for aortic surgery.

Journal Article Interact Cardiovasc Thorac Surg · July 2012 Proximal thoracic aortic reconstruction performed with or without hypothermic circulatory arrest (HCA) is an effective surgical strategy for aortic pathology. In this study, the clinical outcomes of patients undergoing reoperative proximal thoracic aortic ... Full text Link to item Cite

Short- and long-term outcomes in patients undergoing valve surgery with end-stage renal failure receiving chronic hemodialysis.

Journal Article J Thorac Cardiovasc Surg · July 2012 OBJECTIVES: The objective of this study was to evaluate the effect of chronic preoperative hemodialysis for end-stage renal failure in patients undergoing valve surgery. METHODS: A retrospective review of patients undergoing primary valve with or without c ... Full text Link to item Cite

Hemiarch replacement at 28°C: an analysis of mild and moderate hypothermia in 500 patients.

Journal Article Ann Thorac Surg · June 2012 BACKGROUND: During the past decade, use has increased of moderate hypothermic circulatory arrest with antegrade cerebral perfusion for cerebral protection during aortic arch operations. This study examined the use of mild hypothermia in conjunction with un ... Full text Link to item Cite

Risk factors for conversion to cardiopulmonary bypass during off-pump coronary artery bypass surgery.

Journal Article Ann Thorac Surg · June 2012 BACKGROUND: Off-pump coronary artery bypass graft (OPCAB) may be associated with improved hospital outcomes compared with on-pump coronary artery bypass graft. However, intraoperative conversion to on-pump coronary artery bypass graft has been associated w ... Full text Link to item Cite

The society of thoracic surgeons 30-day predicted risk of mortality score also predicts long-term survival.

Journal Article Ann Thorac Surg · January 2012 BACKGROUND: The Society of Thoracic Surgeons Predicted Risk of Mortality (PROM) score is a well-validated predictor of 30-day mortality after cardiac procedures. This study investigated the ability of PROM to predict longer-term survival. METHODS: From Jan ... Full text Link to item Cite

A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery.

Journal Article Transfusion · January 2012 BACKGROUND: Coagulopathy after cardiopulmonary bypass (CPB) is caused by multiple perturbations in cellular and humoral elements of coagulation. A timely and comprehensive method to evaluate hemostasis would be helpful in the management of bleeding patient ... Full text Link to item Cite

The impact of body mass index on morbidity and short- and long-term mortality in cardiac valvular surgery.

Journal Article J Thorac Cardiovasc Surg · November 2011 OBJECTIVE: Limited data exist on patients with cardiac cachexia or morbid obesity presenting for valvular heart surgery. The objective of this study was to investigate the relationship between body mass index and morbidity and mortality after valvular surg ... Full text Link to item Cite

Impact of preoperative renal dysfunction in patients undergoing off-pump versus on-pump coronary artery bypass.

Conference Ann Thorac Surg · August 2011 BACKGROUND: The impact of the degree of renal dysfunction (RD) in patients undergoing coronary artery bypass grafting (CABG) ranging from normal to dialysis-dependence is not well defined. METHODS: A retrospective review of 14,199 patients undergoing isola ... Full text Link to item Cite

Impact of preoperative renal dysfunction on long-term survival for patients undergoing aortic valve replacement.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: The impact of the degrees of renal dysfunction (RD) after aortic valve replacement (AVR) has not been well described. The purpose of this study was to compare patients undergoing AVR with a range of renal function from normal to dialysis-depend ... Full text Link to item Cite

Long-term survival for patients with preoperative renal failure undergoing bioprosthetic or mechanical valve replacement.

Journal Article Ann Thorac Surg · April 2011 BACKGROUND: The objective of this study was to assess short-term and long-term outcomes after valve replacement with biologic or mechanical prostheses in patients with preoperative end-stage renal disease on chronic dialysis. METHODS: A retrospective revie ... Full text Link to item Cite

Moderate hypothermia and unilateral selective antegrade cerebral perfusion: a contemporary cerebral protection strategy for aortic arch surgery.

Conference Ann Thorac Surg · August 2010 BACKGROUND: Cerebral protection techniques during aortic arch surgery include deep hypothermic circulatory arrest, retrograde cerebral perfusion, and (or) antegrade cerebral perfusion. It is unclear whether unilateral selective antegrade cerebral perfusion ... Full text Link to item Cite

Use of balloon aortic valvuloplasty to size the aortic annulus before implantation of a balloon-expandable transcatheter heart valve.

Journal Article JACC Cardiovasc Interv · January 2010 OBJECTIVES: Our aim was to describe the use of balloon aortic valvuloplasty (BAV) to select proper transcatheter heart valve (THV) size. BACKGROUND: Transesophageal echocardiogram (TEE) measurement alone of the aortic annulus may not be adequate to select ... Full text Link to item Cite

Off-pump coronary artery bypass disproportionately benefits high-risk patients.

Conference Ann Thorac Surg · October 2009 BACKGROUND: It is not known which patient subgroups may benefit most from off-pump coronary artery bypass grafting (OPCAB) rather than coronary artery bypass grafting on cardiopulmonary bypass (CPB). METHODS: The Society of Thoracic Surgeons database was q ... Full text Link to item Cite

Racial disparity persists after on-pump and off-pump coronary artery bypass grafting.

Conference Circulation · September 15, 2009 BACKGROUND: Race has been shown to be an independent risk factor for operative mortality after coronary artery bypass grafting (CABG). This study sought to determine the extent to which race is a risk factor for adverse events, long-term mortality, and whe ... Full text Link to item Cite

Aortic valve replacement for aortic stenosis in patients with left ventricular dysfunction.

Conference Ann Thorac Surg · September 2009 BACKGROUND: The purpose of this study was to assess the impact of left ventricular dysfunction and other risk factors on short- and mid-term outcomes after aortic valve replacement for aortic stenosis. METHODS: From January 1, 2002, to December 31, 2007, 7 ... Full text Link to item Cite

Long-term outcomes after isolated aortic valve replacement in octogenarians: a modern perspective.

Conference Ann Thorac Surg · November 2008 BACKGROUND: With the recent advent of percutaneous valve therapy, an increased need for the evaluation of outcomes after open aortic valve replacement (AVR) in elderly patients is warranted. This study compares the short- and long-term survival outcomes of ... Full text Link to item Cite

Off-pump coronary bypass provides reduced mortality and morbidity and equivalent 10-year survival.

Conference Ann Thorac Surg · October 2008 BACKGROUND: This study compared in-hospital major adverse cardiac events (MACE) and long-term survival after off-pump (OPCAB) vs on-pump (CPB) coronary artery bypass grafting (CABG). METHODS: Reviewed were 12,812 consecutive isolated CABG patients from 199 ... Full text Link to item Cite

Can balloon aortic valvuloplasty help determine appropriate transcatheter aortic valve size?

Journal Article JACC Cardiovasc Interv · October 2008 OBJECTIVES: We sought to study the potential role of balloon aortic valvuloplasty (BAV) in sizing the aortic annulus in patients before transcatheter heart valve (THV) implantation. BACKGROUND: Despite clinicians' growing experience with THV procedures, th ... Full text Link to item Cite

Antithrombin deficiency increases thrombin activity after prolonged cardiopulmonary bypass.

Journal Article Anesth Analg · March 2008 BACKGROUND: Antithrombin (AT) levels decrease during cardiopulmonary bypass (CPB), particularly when combined with deep hypothermic circulatory arrest (DHCA). Low AT levels might lead to imbalance of pro- and anticoagulant factors promoting systemic thromb ... Full text Link to item Cite

PERCUTANEOUS AORTIC VALVES: Predicting appropriate size

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2008 Cite

Coagulopathy after cardiopulmonary bypass in Jehovah's Witness patients: management of two cases using fractionated components and factor VIIa.

Journal Article Anesth Analg · April 2007 BACKGROUND: Changes in the Jehovah's Witness (JW) blood refusal policy now give members the personal choice to accept certain processed fractions of blood, such as factor concentrates and cryoprecipitate. METHODS: Two JW patients undergoing complex aortic ... Full text Link to item Cite

Early experience with activated recombinant factor VII for intractable hemorrhage after cardiovascular surgery.

Journal Article Ann Thorac Surg · April 2005 BACKGROUND: Intractable hemorrhage after complex cardiovascular operations is a serious and potentially lethal complication. We report our experience with the use of activated recombinant factor VIIa (rFVIIa) as rescue therapy for patients with refractory ... Full text Link to item Cite

Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5.

Journal Article Ann Thorac Surg · April 2001 BACKGROUND: Chronic heart failure is associated with impairment of the myocardial beta-adrenergic receptor (beta-AR) system. In this study, the effects of G protein-coupled receptor kinase 5 (GRK5) overexpression on myocardial performance were directly ass ... Full text Link to item Cite

The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants.

Journal Article J Thorac Cardiovasc Surg · July 2000 OBJECTIVE: Pulmonary transplantation has become the preferred treatment for end-stage lung disease, but application of the procedure is limited because of a paucity of donors. One way to solve donor limitations is to use animal organs as a donor source or ... Full text Link to item Cite

The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants

Journal Article Journal of Thoracic and Cardiovascular Surgery · January 1, 2000 Objective: Pulmonary transplantation has become the preferred treatment for end-stage lung disease, but application of the procedure is limited because of a paucity of donors. One way to solve donor limitations is to use animal organs as a donor source or ... Full text Cite

Right ventricular dysfunction after cardiac transplantation: primarily related to status of donor heart.

Journal Article Ann Thorac Surg · November 1999 BACKGROUND: It is unclear whether right ventricular dysfunction after transplantation is due to donor brain death-related myocardial injury or recipient pulmonary hypertension. METHODS: A canine donor model of brain death and a monocrotaline pyrrole-induce ... Full text Link to item Cite

Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension.

Journal Article Ann Thorac Surg · April 1999 BACKGROUND: Chronic pulmonary hypertension can lead to compensatory changes in the right ventricle. In this study, the adaptive mechanisms of the right ventricle in the setting of pulmonary hypertension were assessed at the molecular and functional level u ... Full text Link to item Cite

Myocardial recovery after ischemia and reperfusion injury is significantly impaired in hearts with transgenic overexpression of beta-adrenergic receptor kinase.

Journal Article Circulation · November 10, 1998 BACKGROUND: beta-Adrenergic receptor kinase 1 (beta ARK1) mediates beta-adrenergic receptor signaling via receptor phosphorylation, which results in functional uncoupling. The physiological importance of beta ARK1 on cardiac performance in the setting of i ... Link to item Cite

Myocardial recovery after ischemia and reperfusion injury is significantly impaired in hearts with transgenic overexpression of β- adrenergic receptor kinase

Journal Article Circulation · November 10, 1998 Background - β-Adrenergic receptor kinase 1 (βARK1) mediates β- adrenergic receptor signaling via receptor phosphorylation, which results in functional uncoupling. The physiological importance of βARK1 on cardiac performance in the setting of ischemia and ... Cite

Right ventricular function in orthotopic total atrioventricular heart transplantation.

Journal Article J Heart Lung Transplant · August 1998 BACKGROUND: Total orthotopic heart transplantation was recently introduced into clinical practice as an alternative technique of orthotopic heart transplantation, adding bicaval and left and right pulmonary vein anastomoses to pulmonary artery and ascendin ... Link to item Cite

Hemodynamic and inotropic effects of milrinone after heart transplantation in the setting of recipient pulmonary hypertension.

Journal Article J Heart Lung Transplant · July 1998 BACKGROUND: Right ventricular failure remains an important cause of early morbidity and death after heart transplantation and is commonly related to preexistent recipient chronic pulmonary hypertension, which occurs as a result of long-standing congestive ... Link to item Cite

Pharmacological strategies for improving diastolic dysfunction in the setting of chronic pulmonary hypertension.

Journal Article Circulation · April 28, 1998 BACKGROUND: Right ventricular (RV) hypertrophy is an adaptive process that occurs in the setting of chronic pulmonary hypertension (CPH) and can lead to alterations in normal RV diastolic properties. This study was designed to investigate the effects of NO ... Full text Link to item Cite

Physiologic effects of extracellular superoxide dismutase transgene overexpression on myocardial function after ischemia and reperfusion injury.

Journal Article J Thorac Cardiovasc Surg · February 1998 OBJECTIVE: Myocardial injury after ischemia and reperfusion may be mediated, in part, by oxygen-derived free radicals. In this study the protective effects of extracellular superoxide dismutase overexpression were directly assessed in the hearts of transge ... Full text Link to item Cite

Total respiratory support from swine lungs in primate recipients.

Journal Article J Thorac Cardiovasc Surg · January 1998 UNLABELLED: The use of nonhuman lung donors, such as swine, has the potential to provide an unlimited supply of organs. However, hyperacute rejection has prevented pulmonary xenotransplantation. OBJECTIVE: Our aim was to test the hypothesis that immunodepl ... Full text Link to item Cite

Pulmonary vascular impedance and recipient chronic pulmonary hypertension following cardiac transplantation.

Journal Article Chest · December 1997 STUDY OBJECTIVES: Recipient chronic pulmonary hypertension (CPH), secondary to long-standing congestive heart failure, represents a significant risk factor for right ventricular (RV) dysfunction following orthotopic cardiac transplantation (TX). This study ... Full text Link to item Cite

Right ventricular adaptation to increased afterload after orthotopic cardiac transplantation in the setting of recipient chronic pulmonary hypertension.

Journal Article Circulation · November 4, 1997 BACKGROUND: Right ventricular (RV) failure remains an important risk factor for early morbidity and mortality after orthotopic cardiac transplantation and is most commonly related to preexistent chronic pulmonary hypertension (CPH) in the recipient, which ... Link to item Cite

Right ventricular adaptation to increased afterload after orthotopic cardiac transplantation in the setting of recipient chronic pulmonary hypertension

Journal Article Circulation · November 4, 1997 Background: Right ventricular (RV) failure remains an important risk factor for early morbidity and mortality after orthotopic cardiac transplantation and is most commonly related to preexistent chronic pulmonary hypertension (CPH) in the recipient, which ... Cite

Effects of nitric oxide after cardiac transplantation in the setting of recipient pulmonary hypertension.

Journal Article Ann Thorac Surg · June 1997 BACKGROUND: Recipient pulmonary hypertension secondary to chronic congestive heart failure is a significant risk factor for right ventricular failure after cardiac transplantation. In this study, the hemodynamic and inotropic effects of nitric oxide (NO) w ... Link to item Cite

Hemodynamic and inotropic effects of nitric oxide in pulmonary hypertension.

Journal Article J Surg Res · May 1997 Right ventricular failure following cardiac transplantation is most commonly related to pre-existent recipient pulmonary hypertension secondary to chronic congestive heart failure. Although nitric oxide has had some role clinically in improving pulmonary h ... Full text Link to item Cite

An adult canine model of chronic pulmonary hypertension for cardiopulmonary transplantation.

Journal Article J Heart Lung Transplant · May 1997 BACKGROUND: This study establishes a chemically-induced canine model of chronic pulmonary hypertension (CPH) using monocrotaline pyrrole (MCTP) and then characterizes this model in terms of hemodynamic, morphologic, and cardiac functional changes. METHODS: ... Link to item Cite

Nitric oxide improves pulmonary vascular impedance, transpulmonary efficiency, and left ventricular filling in chronic pulmonary hypertension.

Journal Article J Thorac Cardiovasc Surg · May 1997 OBJECTIVE: Chronic pulmonary hypertension is difficult to treat and despite the introduction of several therapeutic options, no single therapy is universally recommended. Nitric oxide has had some role clinically in improving pulmonary hemodynamics in this ... Full text Link to item Cite

Pulmonary hemodynamics and blood flow characteristics in chronic pulmonary hypertension.

Journal Article Ann Thorac Surg · March 1997 BACKGROUND: Lung transplantation is now an acceptable form of therapy for pulmonary hypertension, but controversy remains regarding the most appropriate surgical procedure. In this study, the changes in pulmonary vascular mechanics occurring in the setting ... Full text Link to item Cite

Milrinone improves pulmonary hemodynamics and right ventricular function in chronic pulmonary hypertension.

Journal Article Ann Thorac Surg · March 1997 BACKGROUND: Right ventricular failure after cardiac transplantation is commonly related to preexisting recipient pulmonary hypertension. This study was designed to investigate the effects of intravenous milrinone on pulmonary hemodynamic indices and right ... Full text Link to item Cite

Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor.

Journal Article J Mol Cell Cardiol · March 1997 Transgenic mice overexpressing the human beta 2-adrenergic receptor gene were compared with wild mice type in terms of cardiac function, using a modified work-performing isolated murine heart preparation and on-line computer analysis. A preload-dependent e ... Full text Link to item Cite

Brain death alters cardiopulmonary hemodynamics and impairs right ventricular power reserve against an elevation of pulmonary vascular resistance.

Journal Article Chest · March 1997 Right ventricular (RV) failure, which is a leading cause of early morbidity and mortality following cardiac transplantation, is attributed to the inability of the donor RV to acutely compensate for the recipient's elevated pulmonary vascular resistance (PV ... Full text Link to item Cite

Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model.

Journal Article J Thorac Cardiovasc Surg · February 1997 UNLABELLED: Pulmonary transplantation is currently limited by the number of suitable cadaver donor lungs. For this reason, pulmonary xenotransplantation is currently being investigated. OBJECTIVE: Our goal was to assess the role of complement in pulmonary ... Full text Link to item Cite

Right ventricular failure--insights provided by a new model of chronic pulmonary hypertension.

Journal Article Transplantation · January 27, 1997 This study was designed to examine the effects of both nitric oxide and milrinone on pulmonary hemodynamics and right ventricular function using a newly established model of monocrotaline pyrrole-induced chronic pulmonary hypertension. Sixteen mongrel dogs ... Full text Link to item Cite

Brain death further promotes ischemic reperfusion injury of the rabbit myocardium.

Journal Article Ann Thorac Surg · December 1996 BACKGROUND: Little is known about preload-dependent cardiac function after brain death (BD) and subsequent graft preservation. METHODS: A validated model of BD in rabbits was developed and myocardial performance was studied after BD induction and 1 hour of ... Full text Link to item Cite

Extracellular superoxide dismutase transgene overexpression preserves postischemic myocardial function in isolated murine hearts.

Journal Article Circulation · November 1, 1996 BACKGROUND: Myocardial injury after ischemia and reperfusion may be mediated, at least in part, by oxygen-derived free radicals; this supposition is supported by the observation that significant quantities of these radicals are generated during reperfusion ... Link to item Cite

Extracellular superoxide dismutase transgene overexpression preserves postischemic myocardial function in isolated murine hearts

Journal Article Circulation · November 1, 1996 Background: Myocardial injury after ischemia and reperfusion may be mediated, at least in part, by oxygen-derived free radicals: this supposition is supported by the observation that significant quantities of these radicals are generated during reperfusion ... Cite

Preload-recruitable stroke work relationships and diastolic dysfunction in the brain-dead organ donor

Journal Article Circulation · November 1, 1996 Background: Acute failure is an important cause of morbidity and mortality transplantation, and it may be associated with myocardial changes that occur during brain death (BD). This study investigates the changes in biventricular systolic and diastolic fun ... Cite

Total atrioventricular cardiac transplantation preserves atrial systole and ventricular diastolic filling

Journal Article Circulation · November 1, 1996 Background: Total orthotopic heart transplantation was recently introduced into clinical practice as an alternative technique for orthotopic cardiac transplantation. Total cardiac transplantation uses separate bicaval and left and right pulmonary anastomos ... Cite

Nitric oxide improves vascular impedance and efficiency following cardiac transplantation in the setting of recipient pulmonary hypertension

Journal Article Chest · October 1, 1996 Purpose: Recipient chronic pulmonary hypertension (RCPH), leading to right ventricular (RV) failure, results in a significant amount of early morbidity and mortality following orthotopic cardiac transplantation (TX). Inhaled nitric oxide (NO) has a role cl ... Cite

The effects of pulmonary vascular impedance on right ventricular function pre- and post-heart transplantation

Journal Article Chest · October 1, 1996 Purpose: The purpose of this study was to investigate the effects of donor brain death (BD) on right ventricular (RV) function in the setting of elevated pulmonary vascular resistance (PVR). RV failure is a leading cause of early morbidity and mortality fo ... Cite

Vascular impedance characterization in chronic pulmonary hypertension

Journal Article Chest · October 1, 1996 Purpose: Lung transplantation is now an acceptable form of therapy for pulmonary hypertension (PH). Controversy still remains regarding the most appropriate surgical procedure (single lung vs. bilateral lung vs. heart-lung). However, to date, there has bee ... Cite

The combined effects of brain death and cardiac graft preservation on cardiopulmonary hemodynamics and function before and after subsequent heart transplantation.

Journal Article J Heart Lung Transplant · August 1996 BACKGROUND: The combined effects of brain death and graft preservation on right and left ventricular function and on pulmonary hemodynamics after subsequent heart transplantation have not been previously studied. METHODS: Fifty-seven dogs (25.5 +/- 0.3 kg) ... Link to item Cite

Hormonal and hemodynamic changes in a validated animal model of brain death.

Journal Article Crit Care Med · August 1996 OBJECTIVE: To examine the hormonal and hemodynamic changes in a validated animal model of brain death. DESIGN: Prospective, controlled study. SETTING: Experimental research laboratory. SUBJECTS: Adult male mongrel dogs (n = 10). INTERVENTIONS: Brain death ... Full text Link to item Cite

A work-performing heart preparation for myocardial performance analysis in murine hearts.

Journal Article J Surg Res · July 15, 1996 UNLABELLED: The mouse has become the animal of choice for genetic manipulations resulting in altered myocardial function, but assessment of cardiac function is extremely difficult due to the animal's size. This study was designed to establish a work-perfor ... Full text Link to item Cite

Nitric oxide in brain death related cardiovascular dysfunction.

Journal Article J Crit Care · March 1996 PURPOSE: Nitric oxide (NO) is a major regulator of vascular tone, blood pressure, and blood flow, and plays a significant role in disease states associated with hemodynamic alterations. However, the role of NO in association with the effects of brain death ... Full text Link to item Cite

Myocardial beta-adrenergic receptor function and high-energy phosphates in brain death--related cardiac dysfunction.

Journal Article Circulation · November 1, 1995 BACKGROUND: Cardiac failure remains an important problem after heart transplantation and may be associated with events that occur during brain death (BD) before transplantation. In this study, cardiac function is studied after BD, and biochemical evaluatio ... Full text Link to item Cite

The effects of brain death on cardiopulmonary hemodynamics and pulmonary blood flow characteristics.

Journal Article Chest · November 1995 Deterioration of donor lung function contributes to the shortage of donor organs and early postoperative failure after transplantation. A decrease in donor pulmonary function is associated with opacification of lung fields on radiographs, rendering the lun ... Full text Link to item Cite

Complete atrioventricular cardiac transplantation: improved performance compared with the standard technique.

Journal Article Ann Thorac Surg · August 1995 BACKGROUND: There has been renewed clinical interest in an alternative technique to orthotopic cardiac transplantation involving six anastomoses: left pulmonary veins, right pulmonary veins, inferior vena cava, pulmonary artery, aorta, and superior vena ca ... Full text Link to item Cite

Myocardial performance after graft preservation and subsequent cardiac transplantation from brain-dead donors.

Journal Article Ann Thorac Surg · July 1995 BACKGROUND: This study examined the effects of brain death and graft preservation on right and left ventricular function after subsequent cardiac transplantation. METHODS: Seventy-eight dogs underwent 34 orthotopic complete atrioventricular transplantation ... Link to item Cite

Endocrine changes and metabolic responses in a validated canine brain death model.

Journal Article J Crit Care · June 1995 PURPOSE: Endocrinologic and metabolic changes after brain death (BD) have not yet been investigated in a validated animal model. Therefore, the effects of BD on hormonal and metabolic function were studied in 10 dogs (23 to 31 kg). METHODS: BD was induced ... Full text Link to item Cite

Growth inhibition of human Tenon's capsule fibroblasts and rabbit dermal fibroblasts with non-carcinogenic N-alkylated anthracyclines.

Journal Article Graefes Arch Clin Exp Ophthalmol · June 1994 Bleb fibrosis after glaucoma filtering surgery and proliferative vitreoretinopathy after retinal detachment surgery are complications caused by proliferation of fibroblasts or fibroblastlike cells. The anthracycline daunomycin (DNM) has been used for treat ... Full text Link to item Cite

Ocular toxicity of daunomycin: effects of subdivided doses on the rabbit retina after vitreous gas compression.

Journal Article Graefes Arch Clin Exp Ophthalmol · October 1993 Daunomycin is a potent antiproliferative agent which has been shown to prevent experimental proliferative vitreoretinopathy. However, toxic effects on the rabbit retina have been reported even for the lowest effective doses. In a previous report we demonst ... Full text Link to item Cite

N,N-dimethyladriamycin for treatment of experimental proliferative vitreoretinopathy: efficacy and toxicity on the rabbit retina.

Journal Article Exp Eye Res · April 1993 N,N-Dimethyladriamycin (Me-2-ADM) derives from adriamycin (doxorubicin) by N-methylation of its aminosugar moiety. In contrast to the parent agent, Me-2-ADM lacks mutagenicity and carcinogenicity. To evaluate its suitability for treatment of proliferative ... Full text Link to item Cite

Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye.

Journal Article Invest Ophthalmol Vis Sci · April 1993 PURPOSE: Aclacinomycin A is an oligosaccharide anthracycline that, by contrast with daunomycin, lacks carcinogenicity. The authors evaluated the efficacy of aclacinomycin A in prevention of experimental proliferative vitreoretinopathy (PVR) and its toxicit ... Link to item Cite

The effect of combined daunorubicin and triamcinolone acetonide treatment on a refined experimental model of proliferative vitreoretinopathy.

Journal Article Invest Ophthalmol Vis Sci · June 1992 Prior studies have shown that intravitreal daunorubicin (9-15 nmol) and triamcinolone acetonide (2 mg) are effective individually in preventing retinal detachment in experimental proliferative vitreoretinopathy. This report compares the efficacy of the com ... Link to item Cite