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Elizabeth N Pavlisko

Associate Professor of Pathology
Pathology
40 Medicine Circle, South Clin, Durham, NC 27710
Department of Pathology, 3712, Durham, NC 27710

Selected Publications


The diagnosis of asbestosis in the 21st century: a clinicopathological correlation of 102 cases.

Journal Article Ultrastruct Pathol · March 3, 2024 Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been significantly curtailed since the banning of asbestos in in ... Full text Link to item Cite

The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls.

Journal Article Ann Diagn Pathol · February 2024 BACKGROUND: The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error. DESIGN: A databas ... Full text Link to item Cite

The Interplay Between the Immune System, Tumor Suppressor Genes, and Immune Senescence in Mesothelioma Development and Response to Immunotherapy.

Journal Article J Thorac Oncol · November 23, 2023 Despite efforts to ban asbestos mining and manufacturing, mesothelioma deaths in the United States have remained stable at approximately 2500 cases annually. This trend is not unique to the United States but is also a global phenomenon, associated with inc ... Full text Link to item Cite

The 2022 Banff Meeting Lung Report.

Journal Article Am J Transplant · November 4, 2023 The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference-held in Banff, Alberta-focused on non-rejection lung allograft pathology and novel technologies for the detection of allograft injury. A multidisciplinary panel reviewed ... Full text Link to item Cite

Diagnostic Approach to Pulmonary B-Cell Lymphomas in Small Biopsies, with Practical Recommendations to Avoid Misinterpretation.

Journal Article Diagnostics (Basel) · October 26, 2023 Pulmonary lymphomas are rare. With the current less invasive approaches used to obtain material for diagnosis, the diagnosis of pulmonary lymphoma is now frequently established in a small biopsy rather than in a resection. Therefore, the diagnosis has beco ... Full text Link to item Cite

With Comparable Outcomes, Should Early-Stage Lung Cancer Be a Contraindication to Lung Transplant?

Journal Article Ann Thorac Surg · September 12, 2023 BACKGROUND: Active primary lung malignancy remains a strong contraindication to lung transplantation (LTx). However, outcomes are unclear for patients with early-stage non-small cell lung cancer (NSCLC) who undergo LTx. We hypothesize that patients with ea ... Full text Link to item Cite

Alveolar Mitochondrial Quality Control During Acute Respiratory Distress Syndrome.

Conference Lab Invest · September 2023 Acute respiratory distress syndrome (ARDS) is a leading cause of respiratory failure and death in patients in the intensive care unit. Experimentally, acute lung injury resolution depends on the repair of mitochondrial oxidant damage by the mitochondrial q ... Full text Link to item Cite

Chronological trends in the causation of malignant mesothelioma: Fiber burden analysis of 619 cases over four decades.

Journal Article Environ Res · August 1, 2023 Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontan ... Full text Link to item Cite

Asbestos and Iron.

Journal Article International journal of molecular sciences · August 2023 Theories of disease pathogenesis following asbestos exposure have focused on the participation of iron. After exposure, an open network of negatively charged functional groups on the fiber surface complexes host metals with a preference for iron. Competiti ... Full text Cite

The Banff 2022 Lung Summary Report

Journal Article · May 15, 2023 Cite

Diagnostic approach to prevascular (anterior) mediastinal lymphomas: when thoracic pathology meets hematopathology.

Journal Article Mediastinum · 2023 Lymphomas are among the most common malignant tumors occurring in the anterior/prevascular mediastinum. Their diagnoses can be challenging in small biopsies, the current most common method of sampling of an anterior mediastinal mass. Because the initial cl ... Full text Link to item Cite

Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.

Journal Article Am J Transplant · December 2022 We determined prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP), including timing relative to transplantation, in a multicenter lung recipient cohort. We sought to understand clinical risks that contribute to development of A ... Full text Link to item Cite

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

Journal Article J Heart Lung Transplant · October 2022 We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our inst ... Full text Link to item Cite

Lung allograft standardized histological analysis (LASHA) template: A research consensus proposal.

Journal Article J Heart Lung Transplant · October 2022 BACKGROUND: Routine monitoring of lung-transplanted patients is crucial for the identification of immunological and non-immunological complications. Determining the etiology of acute allograft dysfunction, particularly in alloimmune-mediated disorders, rel ... Full text Link to item Cite

Plasma CXCL9 and CXCL10 at allograft injury predict chronic lung allograft dysfunction.

Journal Article Am J Transplant · September 2022 Histopathologic lung allograft injuries are putative harbingers for chronic lung allograft dysfunction (CLAD). However, the mechanisms responsible are not well understood. CXCL9 and CXCL10 are potent chemoattractants of mononuclear cells and potential prop ... Full text Link to item Cite

Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis.

Journal Article Int J Chron Obstruct Pulmon Dis · 2022 It is proposed that the mechanistic basis for non-neoplastic lung injury with cigarette smoking is a disruption of iron homeostasis in cells after exposure to cigarette smoke particle (CSP). Following the complexation and sequestration of intracellular iro ... Full text Link to item Cite

Transplanting Thoracic COVID-19 Positive Donors: Overcoming the Pandemic

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.

Journal Article Am J Transplant · October 2021 The histopathologic diagnosis of acute allograft injury is prognostically important in lung transplantation with evidence demonstrating a strong and consistent association between acute rejection (AR), acute lung injury (ALI), and the subsequent developmen ... Full text Link to item Cite

Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.

Journal Article J Med Virol · August 2021 Epstein-Barr virus (EBV)-driven posttransplant lymphoproliferative disorder (PTLD) is a serious complication following lung transplant. The extent to which the presence of EBV in PTLD tissue is associated with survival is uncertain. Moreover, whether the h ... Full text Link to item Cite

The diagnosis of asbestosis in the 21st century: a clinicopathological correlation of 102 cases.

Journal Article Ultrastruct Pathol · March 3, 2024 Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been significantly curtailed since the banning of asbestos in in ... Full text Link to item Cite

The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls.

Journal Article Ann Diagn Pathol · February 2024 BACKGROUND: The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error. DESIGN: A databas ... Full text Link to item Cite

The Interplay Between the Immune System, Tumor Suppressor Genes, and Immune Senescence in Mesothelioma Development and Response to Immunotherapy.

Journal Article J Thorac Oncol · November 23, 2023 Despite efforts to ban asbestos mining and manufacturing, mesothelioma deaths in the United States have remained stable at approximately 2500 cases annually. This trend is not unique to the United States but is also a global phenomenon, associated with inc ... Full text Link to item Cite

The 2022 Banff Meeting Lung Report.

Journal Article Am J Transplant · November 4, 2023 The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference-held in Banff, Alberta-focused on non-rejection lung allograft pathology and novel technologies for the detection of allograft injury. A multidisciplinary panel reviewed ... Full text Link to item Cite

Diagnostic Approach to Pulmonary B-Cell Lymphomas in Small Biopsies, with Practical Recommendations to Avoid Misinterpretation.

Journal Article Diagnostics (Basel) · October 26, 2023 Pulmonary lymphomas are rare. With the current less invasive approaches used to obtain material for diagnosis, the diagnosis of pulmonary lymphoma is now frequently established in a small biopsy rather than in a resection. Therefore, the diagnosis has beco ... Full text Link to item Cite

With Comparable Outcomes, Should Early-Stage Lung Cancer Be a Contraindication to Lung Transplant?

Journal Article Ann Thorac Surg · September 12, 2023 BACKGROUND: Active primary lung malignancy remains a strong contraindication to lung transplantation (LTx). However, outcomes are unclear for patients with early-stage non-small cell lung cancer (NSCLC) who undergo LTx. We hypothesize that patients with ea ... Full text Link to item Cite

Alveolar Mitochondrial Quality Control During Acute Respiratory Distress Syndrome.

Conference Lab Invest · September 2023 Acute respiratory distress syndrome (ARDS) is a leading cause of respiratory failure and death in patients in the intensive care unit. Experimentally, acute lung injury resolution depends on the repair of mitochondrial oxidant damage by the mitochondrial q ... Full text Link to item Cite

Chronological trends in the causation of malignant mesothelioma: Fiber burden analysis of 619 cases over four decades.

Journal Article Environ Res · August 1, 2023 Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontan ... Full text Link to item Cite

Asbestos and Iron.

Journal Article International journal of molecular sciences · August 2023 Theories of disease pathogenesis following asbestos exposure have focused on the participation of iron. After exposure, an open network of negatively charged functional groups on the fiber surface complexes host metals with a preference for iron. Competiti ... Full text Cite

The Banff 2022 Lung Summary Report

Journal Article · May 15, 2023 Cite

Diagnostic approach to prevascular (anterior) mediastinal lymphomas: when thoracic pathology meets hematopathology.

Journal Article Mediastinum · 2023 Lymphomas are among the most common malignant tumors occurring in the anterior/prevascular mediastinum. Their diagnoses can be challenging in small biopsies, the current most common method of sampling of an anterior mediastinal mass. Because the initial cl ... Full text Link to item Cite

Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.

Journal Article Am J Transplant · December 2022 We determined prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP), including timing relative to transplantation, in a multicenter lung recipient cohort. We sought to understand clinical risks that contribute to development of A ... Full text Link to item Cite

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

Journal Article J Heart Lung Transplant · October 2022 We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our inst ... Full text Link to item Cite

Lung allograft standardized histological analysis (LASHA) template: A research consensus proposal.

Journal Article J Heart Lung Transplant · October 2022 BACKGROUND: Routine monitoring of lung-transplanted patients is crucial for the identification of immunological and non-immunological complications. Determining the etiology of acute allograft dysfunction, particularly in alloimmune-mediated disorders, rel ... Full text Link to item Cite

Plasma CXCL9 and CXCL10 at allograft injury predict chronic lung allograft dysfunction.

Journal Article Am J Transplant · September 2022 Histopathologic lung allograft injuries are putative harbingers for chronic lung allograft dysfunction (CLAD). However, the mechanisms responsible are not well understood. CXCL9 and CXCL10 are potent chemoattractants of mononuclear cells and potential prop ... Full text Link to item Cite

Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis.

Journal Article Int J Chron Obstruct Pulmon Dis · 2022 It is proposed that the mechanistic basis for non-neoplastic lung injury with cigarette smoking is a disruption of iron homeostasis in cells after exposure to cigarette smoke particle (CSP). Following the complexation and sequestration of intracellular iro ... Full text Link to item Cite

Transplanting Thoracic COVID-19 Positive Donors: Overcoming the Pandemic

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.

Journal Article Am J Transplant · October 2021 The histopathologic diagnosis of acute allograft injury is prognostically important in lung transplantation with evidence demonstrating a strong and consistent association between acute rejection (AR), acute lung injury (ALI), and the subsequent developmen ... Full text Link to item Cite

Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.

Journal Article J Med Virol · August 2021 Epstein-Barr virus (EBV)-driven posttransplant lymphoproliferative disorder (PTLD) is a serious complication following lung transplant. The extent to which the presence of EBV in PTLD tissue is associated with survival is uncertain. Moreover, whether the h ... Full text Link to item Cite

Pilot Study of the Performance of 19-G Needle in Endobronchial Ultrasound-guided Transbronchial Aspiration for the Diagnosis and Testing of Molecular Markers in Lung Cancer.

Journal Article J Bronchology Interv Pulmonol · July 1, 2021 BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become the standard for diagnosis and staging of lung cancer. Historically, 21- and 22-G needles have been paired with EBUS. We evaluated the performance of EBUS-T ... Full text Link to item Cite

Malignant Peritoneal Mesothelioma Arising in Young Adults With Long-standing Indwelling Intra-abdominal Shunt Catheters.

Journal Article Am J Surg Pathol · February 1, 2021 Only 50% to 70% of patients with mesothelioma report asbestos exposure. Other exposures (eg, radiation) play a role in some cases, but some patients have no obvious cause. We describe a series of patients with long-standing indwelling intra-abdominal shunt ... Full text Link to item Cite

Risk Factors for Acute Rejection in the First Year after Lung Transplant. A Multicenter Study.

Journal Article Am J Respir Crit Care Med · August 15, 2020 Rationale: Acute rejection, manifesting as lymphocytic inflammation in a perivascular (acute perivascular rejection [AR]) or peribronchiolar (lymphocytic bronchiolitis [LB]) distribution, is common in lung transplant recipients and increases the risk for c ... Full text Link to item Cite

Detecting Acute Cellular Rejection in Lung Transplant Biopsies by Artificial Intelligence: A Novel Deep Learning Approach

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Acute cellular rejection (ACR), and its relation to chronic lung allograft dysfunction (CLAD), is an important cause of morbidity and mortality in lung transplant patients. ACR occurs in more than one third of lung transplant recipients in the fir ... Full text Cite

NanoString Gene Expression Profiling in Chronic Lung Allograft Dysfunction (CLAD)

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: CLAD, mainly manifest as bronchiolitis obliterans syndrome (BOS), is the leading cause of late death in lung recipients. BOS develops despite routine immunosuppression and its pathogenesis is poorly understood. The histological correlate of BOS is ... Full text Cite

A Multi-Center Study of BAL CXCR3 Chemokines during Allograft Injury after Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: The occurrence of acute allograft injuries remains one of the most important factors responsible for the development of early chronic lung allograft dysfunction. We and others have previously demonstrated a consistent association between acute lun ... Full text Cite

Talc and mesothelioma: mineral fiber analysis of 65 cases with clinicopathological correlation.

Journal Article Ultrastruct Pathol · March 3, 2020 Malignant mesothelioma is strongly associated with prior asbestos exposure. Recently there has been interest in the role of talc exposure in the pathogenesis of mesothelioma. We have analyzed lung tissue samples from a large series of malignant mesotheliom ... Full text Link to item Cite

Malignant Diffuse Mesothelioma in Women: A Study of 354 Cases.

Journal Article Am J Surg Pathol · March 2020 We reviewed 354 cases of malignant diffuse mesothelioma (MM) in women from a database of 2858 histologically confirmed MM cases. There was a pleural predominance with 78% pleural MM and 22% peritoneal MM. The pleural tumors consisted of 72% epithelioid, 19 ... Full text Link to item Cite

Amphiregulin contributes to airway remodeling in chronic allograft dysfunction after lung transplantation.

Journal Article Am J Transplant · March 2020 Chronic lung allograft dysfunction (CLAD), a condition of excess matrix deposition and airways fibrosis, limits survival after lung transplantation. Amphiregulin (Areg) is an epidermal growth factor receptor (EGFR) ligand suggested to regulate airway injur ... Full text Link to item Cite

EBUS-FNA cytologic-histologic correlation of PD-L1 immunohistochemistry in non-small cell lung cancer.

Journal Article J Am Soc Cytopathol · 2020 INTRODUCTION: Immune checkpoint pathway markers induce immune tolerance to non-small cell lung cancer (NSCLC). Therapeutic antibodies targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway have demonstrated efficacy in ... Full text Link to item Cite

Lung cancer: Clinical findings, pathology, and exposure assessment

Chapter · January 1, 2020 Lung cancer is the most common malignancy worldwide and the most common cause of a cancer-related death. Tobacco smoking is the most important cause of lung cancer in most populations although occupational exposures cause an increased risk of lung cancer m ... Full text Cite

Mesothelioma of the tunica vaginalis testis.

Journal Article Hum Pathol · October 2019 Malignant mesothelioma (MM) arising from the serosal membranes of the tunica vaginalis testis (TVT) is rare. Most examples in the published medical literature are individual case reports. This study presents the clinicopathological findings of mesothelioma ... Full text Link to item Cite

Parenteral administration of oral medications in lung transplant recipients: An underrecognized problem.

Journal Article Am J Transplant · May 2019 Microcrystalline cellulose (MCC) is an insoluble material commonly used as a binder and filler in oral medications. Identification of pulmonary intravascular deposition of MCC in transbronchial biopsies from lung transplant (LT) recipients following parent ... Full text Link to item Cite

Acute Rejection (AR) and Lymphocytic Bronchiolitis (LB) in a Multicenter Lung Transplant Cohort

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Novel intronic DICER1 variation associated with pleuropulmonary blastoma in two siblings.

Journal Article BMJ Case Rep · January 20, 2019 Pleuropulmonary blastomas (PPB) are rare aggressive paediatric lung malignancies associated with DICER1 variants. We present two cases, a 2-year-old girl with upper respiratory tract symptoms as well as a 6-month-old girl sibling undergoing screening due t ... Full text Link to item Cite

Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR).

Journal Article Am J Transplant · January 2019 The Lung session of the 2017 14th Banff Foundation for Allograft Pathology Conference, Barcelona focused on the multiple aspects of antibody-mediated rejection (AMR) in lung transplantation. Multidimensional approaches for AMR diagnosis, including classifi ... Full text Link to item Cite

Dusting off the numbers of in situ particle analysis: a 35-year experience.

Journal Article Ultrastruct Pathol · 2019 A variety of fibrotic lung diseases are caused by the inhalation of organic dusts. Many of these disorders have distinctive histopathology and can be readily diagnosed by routine histopathologic examination. However, in some instances, there is overlap in ... Full text Link to item Cite

Malignant peritoneal mesothelioma in patients with endometriosis.

Journal Article J Clin Pathol · November 2018 AIMS: Florid mesothelial hyperplasia is known to result from endometriosis. Well-differentiated papillary mesothelioma and multiloculated peritoneal inclusion cysts have also been described in women with endometriosis. To our knowledge, peritoneal diffuse ... Full text Link to item Cite

Malignant mesothelioma diagnosed at a younger age is associated with heavier asbestos exposure.

Journal Article Carcinogenesis · September 21, 2018 Asbestos exposure is the main etiology of malignant mesothelioma, but there are conflicting data on whether the intensity of exposure modulates the development of this disease. This study considered 594 patients with malignant mesothelioma for whom count d ... Full text Link to item Cite

Dendriform pulmonary ossification leading to bilateral lung transplant: a case report.

Journal Article Virchows Arch · September 2018 Metaplastic ossification within the lung is seen in a variety of diseases, usually as sequela of either a separate primary pulmonary parenchymal disease or an underlying cardiac disorder such as valvular disease. Primary intraalveolar ossification or ossif ... Full text Link to item Cite

Pulmonary blastomycosis presenting as primary lung cancer.

Journal Article BMC Infect Dis · July 18, 2018 BACKGROUND: Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary manifestations. The initial presentatio ... Full text Open Access Link to item Cite

Liposuction-Induced Fat Embolism Syndrome: A Brief Review and Postmortem Diagnostic Approach.

Journal Article Arch Pathol Lab Med · July 2018 Lipoplasty, or liposuction, the surgical process of removing excess fat, is an elective procedure with rising frequency in the United States. Fat embolism syndrome is a clinical diagnosis and is defined as fat in the circulation with an identifiable clinic ... Full text Link to item Cite

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms.

Journal Article Arch Pathol Lab Med · June 2018 CONTEXT: - Malignant mesothelioma (MM) is a component of the BAP1 tumor predisposition syndrome. Other than in BAP1 familial studies, nonmesothelial neoplasms in individuals with MM has not been comprehensively assessed. OBJECTIVE: - To assess the spectrum ... Full text Link to item Cite

Current challenges and opportunities in the management of antibody-mediated rejection in lung transplantation.

Journal Article Curr Opin Organ Transplant · June 2018 PURPOSE OF REVIEW: There is increasing recognition of the importance of antibody-mediated rejection (AMR) after lung transplantation. The development of donor-specific antibodies, a key feature of AMR, occurs in approximately 30% of lung transplant recipie ... Full text Link to item Cite

Nuclear grade and necrosis predict prognosis in malignant epithelioid pleural mesothelioma: a multi-institutional study.

Journal Article Mod Pathol · April 2018 A recently described nuclear grading system predicted survival in patients with epithelioid malignant pleural mesothelioma. The current study was undertaken to validate the grading system and to identify additional prognostic factors. We analyzed cases of ... Full text Link to item Cite

Complement system in lung transplantation.

Journal Article Clin Transplant · April 2018 The complement system is a cascade of multiple proteins that have been known to mediate inflammatory response. This tightly regulated system has been recognized to play a role in adaptive immunity via humoral and cell-mediated processes. There is evidence ... Full text Link to item Cite

Liposuction-induced fat embolism syndrome.

Journal Article BMJ Case Rep · April 18, 2017 Full text Link to item Cite

Malignant peritoneal mesothelioma and Crohn disease.

Journal Article J Clin Pathol · March 2017 AIMS: Mesothelial reaction simulating peritoneal diffuse malignant mesothelioma (MM) has been reported in the setting of Crohn ileitis. To our knowledge, peritoneal MM arising in patients with inflammatory bowel disease (IBD) has not been reported. The pur ... Full text Link to item Cite

Non-Mesothelial Neoplasms in Individuals with Malignant Mesothelioma

Conference LABORATORY INVESTIGATION · February 1, 2017 Link to item Cite

Loxl-2 Contributes To The Development Of Obliterative Bronchiolitis (ob) In Humans

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Differential pathological response and pleural transport of mineral fibres

Conference European Mineralogical Union Notes in Mineralogy · January 1, 2017 The evaluation of mineral fibres within the pleural cavity and the possible subsequent pathological response in this region have the potential to provide important kinetic and pathological information. The pleural cavity, however, is a very dynamic environ ... Full text Cite

Mesothelioma Pathology

Chapter · 2017 Cite

Differential Pathological Response and Pleural Transport of Mineral Fibres

Chapter · 2017 "The state of the art in the field of mineral fibres is illustrated and discussed here, with a multidisciplinary approach taking into account all the different scientific strands (biology, chemistry, epidemiology, mineralogy, physics, ... ... Cite

Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung.

Journal Article Pediatr Pulmonol · October 2016 Bronchopulmonary dysplasia (BPD) is an inflammatory lung disorder common in premature infants who undergo mechanical ventilation with supplemental oxygen. Inhaled nitric oxide (iNO) has been used to prevent experimental and clinical BPD. Earlier studies sh ... Full text Link to item Cite

Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases.

Journal Article Lung Cancer · May 2016 OBJECTIVES: To examine the clinicopathologic characteristics of individuals with diffuse malignant mesothelioma (DMM) occurring concurrently with lung cancer (LC). MATERIALS AND METHODS: A database of approximately 3800 patients with DMM was reviewed, from ... Full text Link to item Cite

Validation and Refinement of Chronic Lung Allograft Dysfunction Phenotypes in Bilateral and Single Lung Recipients.

Journal Article Ann Am Thorac Soc · May 2016 RATIONALE: The clinical course of chronic lung allograft dysfunction (CLAD) is heterogeneous. Forced vital capacity (FVC) loss at onset, which may suggest a restrictive phenotype, was associated with worse survival for bilateral lung transplant recipients ... Full text Link to item Cite

Banff study of pathologic changes in lung allograft biopsy specimens with donor-specific antibodies.

Journal Article J Heart Lung Transplant · January 2016 Featured Publication BACKGROUND: The diagnosis of antibody-mediated rejection (AMR) in the lung transplant is still an area under investigation. We performed a blinded multicenter study to determine if any statistically significant histologic findings in transbronchial biopsy ... Full text Link to item Cite

Malignant mesothelioma not related to asbestos exposure: Analytical scanning electron microscopic analysis of 83 cases and comparison with 442 asbestos-related cases.

Journal Article Ultrastruct Pathol · 2016 Epidemiological studies indicate that 80-90% of mesotheliomas are asbestos related. This suggests that 10-20% are not. Lung fiber burden analysis provides objective information about past exposures to asbestos. We have performed lung fiber burden analysis ... Full text Link to item Cite

Asbestos content of lung tissue in patients with malignant peritoneal mesothelioma: A study of 42 cases.

Journal Article Ultrastruct Pathol · 2016 Lung tissue from 42 peritoneal mesothelioma cases was analyzed by light microscopy and scanning electron microscopy/energy dispersive spectrometry. There were 34 men and 8 women with a mean age of 61 ± 10 years. Also, 17% of cases had histologically confir ... Full text Link to item Cite

Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice.

Journal Article PLoS One · 2016 The gene KRAS is commonly mutated in lung cancer to encode a constitutively active and oncogenic protein that is well established to initiate and maintain lung tumorigenesis. However, the remaining wild-type KRAS protein, or the other family members HRAS a ... Full text Link to item Cite

Sarcomatoid Peritoneal Mesothelioma

Journal Article American Journal of Surgical Pathology · December 2015 Featured Publication Full text Cite

Sarcomatoid Peritoneal Mesothelioma: Clinicopathologic Correlation of 13 Cases.

Conference Am J Surg Pathol · November 2015 Peritoneal mesothelioma is rare, and the sarcomatoid variant is more infrequent, with <30 cases reported to date in the literature. Several case series have described the morphologic features of sarcomatoid peritoneal mesothelioma (SPe); however, the clini ... Full text Link to item Cite

Impact of CLAD Phenotype on Survival After Lung Retransplantation: A Multicenter Study.

Journal Article Am J Transplant · August 2015 Featured Publication Chronic lung allograft dysfunction (CLAD) remains a major problem after lung transplantation with no definitive treatment except redo lung transplantation (re-LTx) in selected candidates. However, CLAD is not a homogeneous entity and different phenotypes e ... Full text Link to item Cite

Iron and Iron-Related Proteins in Asbestosis.

Journal Article J Environ Pathol Toxicol Oncol · 2015 We tested the postulate that iron homeostasis is altered among patients diagnosed to have asbestosis. Lung tissue from six individuals diagnosed to have had asbestosis at autopsy was stained for iron, ferritin, divalent metal transporter 1 (DMT1), and ferr ... Full text Link to item Cite

Increased Amphiregulin Expression Is Associated With Chronic Allograft Dysfunction After Lung Transplantation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Pseudoaneurysm formation after medtronic freestyle porcine aortic bioprosthesis implantation: a word of caution.

Journal Article Ann Thorac Surg · December 2014 BACKGROUND: A growing literature describes aneurysmal deterioration after implantation of the stentless porcine aortic Medtronic Freestyle bioprosthesis (MFB; Medtronic Inc, Minneapolis, MN), with some suggesting inadequate tissue fixation with immune resp ... Full text Link to item Cite

Elevated Hyaluronan Is Associated with Bronchiolitis Obliterans Syndrome

Conference The Journal of Heart and Lung Transplantation · April 2014 Featured Publication Full text Cite

Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity.

Journal Article Am J Respir Crit Care Med · March 1, 2014 Featured Publication RATIONALE: Although innate immunity is increasingly recognized to contribute to lung allograft rejection, the significance of endogenous innate ligands, such as hyaluronan (HA) fragments, in clinical or experimental lung transplantation is uncertain. OBJEC ... Full text Link to item Cite

Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction.

Journal Article Am J Respir Crit Care Med · January 15, 2014 Featured Publication RATIONALE: Emerging evidence suggests a restrictive phenotype of chronic lung allograft dysfunction (CLAD) exists; however, the optimal approach to its diagnosis and clinical significance is uncertain. OBJECTIVES: To evaluate the hypothesis that spirometri ... Full text Link to item Cite

Lung cancer (exposure assessment, pathology, and epidemiology)

Chapter · January 1, 2014 Featured Publication Lung cancer is the most common malignancy worldwide and the most common cause of a cancer-related death. Tobacco smoking is the most important cause of lung cancer in most populations although occupational exposures cause an increased risk of lung cancer m ... Full text Cite

Mesothelioma

Chapter · January 1, 2014 Mesothelioma, literally “tumor of the mesothelium,” is a term often used synonymously with malignant (diffuse) mesothelioma, the malignant neoplasm arising from the serosal linings of the pleural, pericardial, or peritoneal cavities. These major body cavit ... Full text Cite

Pericarditis mediated by respiratory syncytial virus in a hematopoietic stem cell transplant patient.

Journal Article Transpl Infect Dis · August 2013 We describe a case of pericarditis and large pericardial effusion in a 63-year-old African-American man undergoing autologous hematopoietic stem cell transplant for multiple myeloma. Pericardial tissue biopsy demonstrated fibrinous pericarditis, and immuno ... Full text Link to item Cite

Acute cellular and antibody-mediated allograft rejection.

Journal Article Semin Respir Crit Care Med · June 2013 Survival post-lung transplantation remains limited to ∼ 50% at 5 years, far below survival after other solid organ transplants. Allograft rejection is a major cause of this limited survival. At least a third of lung transplant recipients experience acute r ... Full text Link to item Cite

The continued vital role of electron microscopy in the diagnosis of renal disease/dysfunction.

Journal Article Ultrastruct Pathol · February 2013 Ultrastructural examination remains a crucial diagnostic tool for analysis of renal biopsies, along with light and immunofluorescence microscopy. Several advantages of electron microscopy are the ability to detect most forms of glomerular disease/dysfuncti ... Full text Link to item Cite

Restrictive Spirometry At Bronchiolitis Obliterans Syndrome Onset Predicts Worse Survival

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Epithelial clara cell injury occurs in bronchiolitis obliterans syndrome after human lung transplantation.

Journal Article Am J Transplant · November 2012 Featured Publication Bronchiolitis obliterans syndrome (BOS) is a condition of progressive airflow obstruction that affects a majority of lung transplant recipients and limits long-term posttransplant survival. Although epithelial injury appears central to the development of B ... Full text Link to item Cite

Sclerosing hemangioma of the lung: Case report and literature review

Journal Article Pathology Case Reviews · September 1, 2012 ABSTRACT: Sclerosing hemangioma of lung is an unusual neoplasm with distinctive morphological features. Although its histogenesis has been debated for decades, the current concept is that this is a tumor of cells with features most closely resembling type ... Full text Cite

Disruption of iron homeostasis in mesothelial cells after talc pleurodesis.

Journal Article Am J Respir Cell Mol Biol · January 2012 Featured Publication The mechanism for biological effects after exposure to particles is incompletely understood. One postulate proposed to explain biological effects after exposure to particles involves altered iron homeostasis in the host. The fibro-inflammatory properties o ... Full text Link to item Cite

Cardiac angiosarcoma presenting as progressive dyspnea on exertion.

Journal Article J Cardiovasc Med (Hagerstown) · December 2011 Full text Link to item Cite

Acute allograft rejection: cellular and humoral processes.

Journal Article Clin Chest Med · June 2011 Featured Publication Acute cellular rejection affects greater than one-third of lung transplant recipients. Alloreactive T-lymphocytes constitute the basis of lung allograft rejection. Recent evidence supports a more complex immune response to the allograft. Interaction betwee ... Full text Link to item Cite

Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation.

Journal Article Int J Chron Obstruct Pulmon Dis · 2011 Patients with chronic obstructive pulmonary disease (COPD) exhibit dominant features of chronic bronchitis, emphysema, and/or asthma, with a common phenotype of airflow obstruction. COPD pulmonary physiology reflects the sum of pathological changes in COPD ... Full text Open Access Link to item Cite