Scholars@Duke
Gary Lee Pellom

Gary Lee Pellom

Medical Assistant Professor in the Department of Anesthesiology
Anesthesiology
garylee.pellom@duke.edu
Box 3094 Med Ctr, Durham, NC
104 Baker House, Durham, NC

Selected Publications

Differential ventricular ischemic injury: an experimental model of right ventricular failure with a variable degree of left ventricular dysfunction.

Journal Article J Thorac Cardiovasc Surg · October 1988 The hemodynamic manifestations of right ventricular dysfunction after ischemic injury depend not only on the severity of injury but also on the degree of coexistent left ventricular dysfunction. A better understanding of right ventricular failure and of op ... Link to item Cite

Assessment of the intrinsic contractile status of the heart during sepsis by myocardial pressure-dimension analysis.

Journal Article Ann Surg · July 1988 The effect of sepsis on the intrinsic contractile status of the myocardium is best examined in the awake, closed-chest animal with intact circulation because anesthesia, open thoracotomy, and circulatory support are all known to affect hemodynamics. To ful ... Full text Link to item Cite

Quantification of the contractile response to injury: assessment of the work-length relationship in the intact heart.

Journal Article Circulation · September 1987 We used a sonomicrometric determination of ventricular dimension to examine the effect of ischemia and reperfusion on the work-length relationship in the intact heart to develop a useful and precise variable of ventricular contractile response to injury. T ... Full text Link to item Cite

Papillary-annular continuity and left ventricular systolic function after mital valve replacement

Journal Article Circulation · October 29, 1986 The contribution of the subvalvular apparatus to left ventricular function was evaluated in a canine preparation that allowed variation of subvalvular tethering forces after mitral valve replacement. Ten normal dogs were instrumented with micromanometer-ti ... Cite

Dynamic right ventricular dimension. Relation to chamber volume during the cardiac cycle.

Journal Article J Thorac Cardiovasc Surg · June 1986 Whereas the left ventricle has been analyzed extensively, the apparent complexity of right ventricular geometry and contraction has hindered analysis of right ventricular performance by an assessment of instantaneous ventricular dimensions and volume durin ... Link to item Cite

Right ventricular sensitivity to metabolic injury during cardiopulmonary bypass.

Journal Article Arch Surg · March 1986 To determine intrinsic right ventricular susceptibility to metabolic injury, we examined the effect of ischemia and reperfusion during cardiopulmonary bypass on right and left ventricular myocardial adenine nucleotide metabolism in the absence of ventricul ... Full text Link to item Cite

The comparative effects of dopamine and dobutamine on ventricular mechanics after coronary artery bypass grafting: A pressure-dimension analysis

Journal Article Circulation · October 25, 1984 To compare the contractile response to dopamine and dobutamine after coronary artery bypass grafting, 20 patients were instrumented with ultrasonic dimension transducers to measure left ventricular anterior/posterior minor-axis diameter and equatorial wall ... Cite

Effects of delay in administration of potassium cardioplegia to the isolated rat heart.

Journal Article Ann Thorac Surg · April 1984 Ischemic injury to the heart in the period between aortic cross-clamping and administration of cardioplegic solution was evaluated in the normothermic rat heart model. After isolation and control perfusion with oxygenated Krebs-Henseleit bicarbonate buffer ... Full text Link to item Cite

A canine model of acute differential ventricular global ischemic injury

Journal Article Surgical Forum · January 1, 1984 Cite

Myocardial depression by anesthetic agents (halothane, enflurane and nitrous oxide): quantitation based on end-systolic pressure-dimension relations.

Journal Article Am J Cardiol · January 1, 1984 The end-systolic pressure-diameter relation of the left ventricle was used to examine the effect of halothane, enflurane and nitrous oxide on left ventricular (LV) contractility in 10 dogs chronically instrumented with dimension transducers to measure LV d ... Full text Link to item Cite

Myocardial adenosine triphosphate levels during early sepsis.

Journal Article Arch Surg · December 1983 Myocardial adenosine triphosphate (ATP) levels were determined in rats given sepsis by cecal ligation. Determinations were made after a set time interval, prior to the onset of obtundent effects and immobility, in an attempt to avoid the well-documented, d ... Full text Link to item Cite

The mechanism of halothane-induced myocardial depression. Altered diastolic mechanics versus impaired contractility.

Journal Article J Thorac Cardiovasc Surg · June 1983 Although halothane has been shown to depress left ventricular function, it remains a common alternative to narcotic anesthesia in cardiac operations. To clarify the mechanism by which this functional depression occurs (direct decrease in contractility vers ... Link to item Cite

The influence of time on the response to dopamine after coronary artery bypass grafting: assessment of left ventricular performance and contractility using pressure/dimension analyses.

Journal Article Ann Thorac Surg · January 1983 Pressure and dimension analyses were used to quantitate the changing cardiac response to dopamine over a 24-hour interval after coronary artery bypass grafting (CABG). Ultrasonic dimension transducers were utilized to measure the minor-axis diameter of the ... Full text Link to item Cite

Improved tolerance to ischemia in hypertrophied myocardium by preischemic enhancement of adenosine triphosphate.

Journal Article J Thorac Cardiovasc Surg · July 1982 In prior studies from this laboratory to determine the mechanisms whereby hypertrophied myocardium is more sensitive to ischemic injury than normal myocardium, it was demonstrated that hypertrophied rat hearts have lower basal high-energy phosphate levels ... Link to item Cite

The effect of PEEP on left ventricular diastolic dimensions and systolic performance following myocardial revascularization.

Journal Article Ann Thorac Surg · June 1982 To quantitate the alterations in left ventricular (LV) dimensions and performance at successive levels of positive end-expiratory pressure (PEEP), 16 patients undergoing coronary artery bypass grafting (CABG) underwent instrumentation with ultrasonic dimen ... Full text Link to item Cite

Ribose-enhanced myocardial recovery following ischemia in the isolated working rat heart.

Journal Article J Thorac Cardiovasc Surg · March 1982 Recovery for myocardial adenosine triphosphate (ATP) following moderate periods of ischemic is dependent upon the availability of adenosine monophosphate (AMP) and diphosphate (ADP) for rephosphorylation. Recovery of AMP and ADP levels following ischemia i ... Link to item Cite

Response of hypertrophied myocardium to ischemia: correlation with biochemical and physiological parameters.

Journal Article J Thorac Cardiovasc Surg · June 1981 The increased susceptibility of hypertrophied hearts to ischemic injury during cardiac operations has long been recognized. Although the imbalances in oxygen supply and demand which may occur with hypertrophy during hypotension, ventricular fibrillation, o ... Link to item Cite

The effect of verapamil on the diastolic mechanics of the left ventricle

Journal Article American Journal of Cardiology · January 1, 1981 Full text Cite

An improved technique for producing ventricular hypertrophy with a subcoronary valvular aortic stenosis model.

Journal Article Ann Thorac Surg · September 1980 Although techniques for producing aortic valve stenosis proximal to the ostia of the coronary arteries have been described in experimental animals, only moderate left ventricular hypertrophy has been obtained. A technique for plicating the noncoronary sinu ... Full text Link to item Cite

Correlation of mitochondrial function and ischemic contracture.

Journal Article J Thorac Cardiovasc Surg · April 1980 Structural and functional changes in the mitochondrium have been described following timed cardiac ischemia. However, mitochondrial abnormalities associated with acute muscular dysfunction have not been well defined. In the present investigation, the isola ... Link to item Cite

Protection of mitochondrial function during ischemia by potassium cardioplegia: correlation with ischemic contracture.

Journal Article Circulation · August 1979 The effect of potassium cardioplegia on mitochondrial function was evaluated in the ischemic isolated rat heart. Mitochondrial function as well as adenosine triphosphate (ATP) levels were determined at the initiation of ischemic contracture, at the complet ... Full text Link to item Cite

Effect of B-15,000 (Iopamidol), a new nonionic contrast agent, on cardiac function of the isolated rat heart.

Journal Article Invest Radiol · 1979 The isolated rat heart model was used to examine the effect of a new nonionic contrast agent, B-15,000 (Iopamidol), on cardiac function. Comparative studies were performed with Amipaque, Renografin 60, Renografin 76, and Vascoray. The three ionic contrast ... Full text Link to item Cite