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Brent A. Hanks

Associate Professor of Medicine
Medicine, Medical Oncology
LSRC, Box 91004, Pharmacology and Cancer Biology, Durham, NC 27708
308 Research Drive, LSRC, Room C162, Durham, NC 27708

Selected Presentations & Appearances


Inflammasome-Wnt Ligand Signaling Axis Promotes Immune Escape During Anti-PD-1 Antibody Immunotherapy. - 2018 Annual Conference · November 7, 2018 Invited Talk Society for Immunotherapy of Cancer, Washington, DC
Tumor-mediated Modulation of Immunometabolism as a Mechanism of Immunotherapy Resistance. - Immuno-Oncology Summit · August 27, 2018 - August 27, 2018 Invited Talk CHI, Boston, MA
Investigating the Role of Innate Immunity in Adaptive Resistance to Cancer Immunotherapy - Biomarkers and Immuno-Oncology World Congress · June 13, 2018 - June 13, 2018 Invited Talk CHI, Boston, MA
Role of the Wnt-β-catenin Signaling Pathway in Tumor-mediated Immune Evasion and Immunotherapy Resistance · March 27, 2018 - March 29, 2018 Invited Talk Duke-NUS, Singapore
Uncovering the Role of the Wnt-β-catenin Signaling Pathway in Driving Melanoma Immune Evasion and Immunotherapy Resistance - 2018 Duke Solid Tumor Therapeutics Program Annual Retreat. · March 19, 2018 - March 19, 2018 Invited Talk Duke University, Durham, NC
Uncovering the Role of the Wnt-β-catenin Signaling Pathway in Driving Melanoma Immune Evasion and Immunotherapy Resistance - 2018 Pinnel Center Talk · March 2, 2018 - March 2, 2018 Invited Talk Duke University, Durham, NC
The Immune System and Cancer: Mechanisms of Immune Suppression - ASCO-SITC Lecture · June 1, 2017 - June 2, 2017 Invited Talk ASCO , McCormick Place, Chicago, IL
Utilizing Pre-Clinical Melanoma Models to Design Rational Combinatorial Immunotherapy Regimens : Lessons Learned from Targeting the TGF-������ Signaling Pathway. - 2017 Melanoma Research Alliance Annual Meeting · February 14, 2017 - February 15, 2017 Invited Talk Melanoma Research Alliance, Washington, DC
Utilizing Pre-Clinical Melanoma Models to Design Rational Combinatorial Immunotherapy Regimens : Lessons Learned from Targeting the TGF-������ Signaling Pathway. - 2017 Melanoma Research Alliance Annual Meeting · February 14, 2017 - February 15, 2017 Invited Talk Melanoma Research Alliance, Washington, DC
Utilizing Pre-Clinical Melanoma Models to Design Rational Combinatorial Immunotherapy Regimens : Lessons Learned from Targeting the TGF-������ Signaling Pathway. - 2017 Melanoma Research Alliance Annual Meeting · February 14, 2017 - February 15, 2017 Invited Talk Melanoma Research Alliance, Washington, DC
The Wnt5a-β-catenin Pathway Triggers a Metabolic Switch That Drives Indoleamine 2,3-dioxygenase Activity and Dendritic Cell Tolerization in the Melanoma Microenvironment. - Society for Immunotherapy of Cancer 2016 Annual Meeting · November 11, 2016 - November 13, 2016 Invited Talk Society for Immunotherapy of Cancer (SITC), Washington, DC
Targeting the TGF-β Signaling Pathway to Augment the Efficacy of Immunotherapy Checkpoint Inhibitors in Melanoma. - 2nd Annual Summit on Melanoma · September 18, 2015 - September 20, 2015 Invited Talk DAVA Oncology, The Langham Hotel, Pasadena, CA
Basic Mechanisms of Tumor Immune Suppression - SITC Regional Advances in Cancer Immunotherapy · May 29, 2015 - May 29, 2015 Lecture Society for Immunotherapy of Cancer, McCormick Place, Chicago, IL
Modulating the Immune Response. - SITC Regional Advances in Cancer Immunotherapy · October 3, 2014 - October 4, 2015 Lecture Society for Immunotherapy of Cancer, Charlotte, NC
Exploring Dendritic Cell-Targeted Immune Evasion Mechanisms in Melanoma: Developing Pharmacological Strategies to Synergistically Enhance Immunotherapy Efficacy · August 22, 2014 - August 23, 2014 Invited Talk Georgia Regents University, Georgia Regents University, Augusta, GA

Service to the Profession


Manuscript Reviewer - Journal of Clinical Investigation · January 1, 2014 - November 1, 2015 Editorial Activities
Manuscript Reviewer - Frontiers in Immunology · 2014 Editorial Activities
Manuscript Reviewer - Cancer Immunology Immunotherapy · 2014 Editorial Activities
Manuscript Reviewer - Plos One · January 1, 2013 - November 24, 2015 Editorial Activities

Service to Duke


Pharmacology and Cancer Biology Chair Search Committee (Department) · 2021 - 2022 Committee Service
· 2017 Committee Service Duke University ,

Clinical Activities


Manage patients with advanced skin cancers including melanoma, Merkel cell carcinoma, squamous cell carcinoma, and basal cell carcinoma.  One full clinic day weekly.   In-patient advanced skin cancer consults.