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Haywood Laverne Brown

Haywood Laverne Brown

Professor Emeritus of Obstetrics and Gynecology
Obstetrics and Gynecology, Maternal Fetal Medicine
haywood.brown@duke.edu
Box 3084 Med Ctr, Durham, NC 27710
203 Baker House, Durham, NC 27710

Selected Publications

Preventable Maternal Mortality -Diagnosis and Management of Mental Health and Substance Use Disorders.

Journal Article Obstet Gynecol Clin North Am · March 2025 Maternal mortality has increased over past decades. The majority of deaths are secondary to mental health and substance use disorders, with over 80% being preventable. Screening for mental health should be offered to all pregnant women and should be admini ... Full text Link to item Cite

Reconsidering the Impact of Race on Maternal Mental Health.

Journal Article Obstet Gynecol Clin North Am · March 2025 Maternal mental health conditions are the leading cause of death for women in the first year postpartum with suicide and addiction overdose deaths accounting for the majority of postpartum deaths. Non-Hispanic Black women are twice as likely as White women ... Full text Link to item Cite

Who's Haywood? Path to Leadership: I Am NO Jackie Robinson.

Journal Article Clin Obstet Gynecol · June 1, 2024 Having been afforded many opportunities throughout my academic career, I took on the challenges that chronicled my path to leadership. In many instances, I was the first person of color to enter that educational and leadership environment. I am grateful to ... Full text Link to item Cite

Opportunities in the Postpartum Period to Reduce Cardiovascular Disease Risk After Adverse Pregnancy Outcomes: A Scientific Statement From the American Heart Association.

Journal Article Circulation · February 13, 2024 Adverse pregnancy outcomes are common among pregnant individuals and are associated with long-term risk of cardiovascular disease. Individuals with adverse pregnancy outcomes also have an increased incidence of cardiovascular disease risk factors after del ... Full text Link to item Cite

Fathers' Perspectives on Fatherhood and Paternal Involvement During Pregnancy and Childbirth.

Journal Article Health Educ Behav · December 2023 There is limited research that specifically explores paternal involvement during pregnancy and childbirth. To address this gap, we completed a series of focus groups with fathers to examine social, cultural, and environmental factors that influence behavio ... Full text Link to item Cite

The Role of Gynecologic Surgical Training for the Practicing Obstetrician

Journal Article Journal of Gynecologic Surgery · December 1, 2022 A decline in surgical training and skill acquisition in gynecology has been widely recognized and has been receiving much attention during the past 5 years. Potential solutions have been discussed in a number of publications and forums. A system of trackin ... Full text Cite

Colorectal Endoscopic Stenting Trial (CReST) for obstructing left-sided colorectal cancer: randomized clinical trial.

Journal Article Br J Surg · October 14, 2022 BACKGROUND: Colorectal cancer often presents with obstruction needing urgent, potentially life-saving decompression. The comparative efficacy and safety of endoluminal stenting versus emergency surgery as initial treatment for such patients is uncertain. M ... Full text Link to item Cite

The impact of excessive gestational weight gain timing on neonatal outcomes in women with class III obesity.

Journal Article J Matern Fetal Neonatal Med · August 2022 OBJECTIVE: This study evaluated the influence of early gestational weight gain (GWG) on neonatal outcomes among women with class III obesity. STUDY DESIGN: Retrospective cohort of women with class III obesity who gained more than the Institute of Medicine ... Full text Link to item Cite

Maternal weight gain and neonatal outcomes in women with class III obesity.

Journal Article J Matern Fetal Neonatal Med · February 2022 OBJECTIVE: Obesity in the USA continues to be a prominent medical and public health concern. Due to increasing rates of maternal obesity, the current Institute of Medicine (IOM) guidelines recommend 11-20 pounds of total weight gain during pregnancy in wom ... Full text Link to item Cite

A guidelines-consistent carrier screening panel that supports equity across diverse populations.

Journal Article Genet Med · January 2022 PURPOSE: The American College of Obstetricians and Gynecologists (ACOG) and the American College of Medical Genetics and Genomics (ACMG) suggest carrier screening panel design criteria intended to ensure meaningful results. This study used a data-driven ap ... Full text Link to item Cite

Diagnosis of Vaginitis: New Thinking for a New Era.

Journal Article Popul Health Manag · October 2021 Full text Link to item Cite

Black Lives and the Police.

Journal Article J Natl Med Assoc · August 2021 INTRODUCTION: Protests and the call to action in the aftermath of the deaths of Black citizens at the hands of police officers have reawakened the consciousness of American society on policing and the need for reforms. Racism in policing has a long history ... Full text Link to item Cite

Maternal Weight Gain and Infant Birth Weight in Women with Class III Obesity.

Journal Article Am J Perinatol · July 2021 OBJECTIVE: The aim of this study is to describe the impact of maternal weight gain on infant birth weight among women with Class III obesity. STUDY DESIGN: Retrospective cohort of women with body mass index (BMI) ≥40 kg/m2 at initial prenatal visit, delive ... Full text Link to item Cite

Diagnostic Cardiovascular Imaging and Therapeutic Strategies in Pregnancy: JACC Focus Seminar 4/5.

Journal Article J Am Coll Cardiol · April 13, 2021 The prevalence of cardiovascular disease (CVD) in pregnancy, both diagnosed and previously unknown, is rising, and CVD is a leading cause of maternal morbidity and mortality. Historically, women of child-bearing potential have been underrepresented in rese ... Full text Link to item Cite

Team-Based Care of Women With Cardiovascular Disease From Pre-Conception Through Pregnancy and Postpartum: JACC Focus Seminar 1/5.

Journal Article J Am Coll Cardiol · April 13, 2021 The specialty of cardio-obstetrics has emerged in response to the rising rates of maternal morbidity and mortality related to cardiovascular disease (CVD) during pregnancy. Women of childbearing age with or at risk for CVD should receive appropriate counse ... Full text Link to item Cite

Black women health inequity: The origin of perinatal health disparity.

Journal Article J Natl Med Assoc · February 2021 Black enslaved women endured sexual exploitation and reproductive manipulation to produce a labor workforce on the southern plantations during the Antebellum Period. Health care inequity has continued from slavery and into the 21th century primarily due of ... Full text Link to item Cite

Improving the Diagnosis of Vulvovaginitis: Perspectives to Align Practice, Guidelines, and Awareness.

Journal Article Popul Health Manag · October 2020 Vulvovaginitis is a frequent reason for women to see a health care provider and has been linked to adverse reproductive and psychosocial consequences. Accurate diagnosis is a cornerstone of effective treatment, yet misdiagnosis of this condition approaches ... Full text Link to item Cite

Post-Traumatic Stress Disorder and Severe Maternal Morbidity.

Journal Article Obstet Gynecol Clin North Am · September 2020 Post-traumatic stress disorder (PTSD) accompanies miscarriage, intrauterine fetal demise, and preterm birth. Levels of PTSD may be higher for women who experience acute, life-threatening events during labor and delivery. Severe maternal morbidities or near ... Full text Link to item Cite

Pregnancy Complications, Cardiovascular Risk Factors, and Future Heart Disease.

Journal Article Obstet Gynecol Clin North Am · September 2020 Heart disease is the leading cause of mortality in adult women. Beyond the traditional risk factors of obesity, diabetes, and hypercholesterolemia, women with the pregnancy complications of preeclampsia, gestational diabetes, prematurity, and low birth wei ... Full text Link to item Cite

Opioid Management in Pregnancy and Postpartum.

Journal Article Obstet Gynecol Clin North Am · September 2020 Pregnant and postpartum women with opiate use disorder present a challenge in perinatal care. It is important for health care teams to provide sensitive and compassionate evidence-based care for these women, who often are stigmatized during the prenatal, d ... Full text Link to item Cite

Telehealth in Maternity Care.

Journal Article Obstet Gynecol Clin North Am · September 2020 The use of telehealth is gaining momentum in providing obstetric care. Telehealth through various platforms provides obstetricians and gynecologists and other providers of obstetric and postpartum care with the tools to better facilitate prenatal, intrapar ... Full text Link to item Cite

Changing the Postpartum Care Paradigm.

Journal Article Obstet Gynecol Clin North Am · September 2020 Full text Link to item Cite

Impact of Excess Weight Gain on Risk of Postpartum Infection in Class III Obesity

Journal Article AJP Reports · July 1, 2020 Objective To assess the impact of gestational weight gain >20 pounds (more than Institute of Medicine [IOM] recommendations) on postpartum infectious morbidity in women with class III obesity. Methods This is a retrospective cohort of term, nonanomalous si ... Full text Cite

OB/GYN Providers' Knowledge of Racial and Ethnic Reproductive Health Disparities.

Journal Article J Natl Med Assoc · June 2020 OBJECTIVE: This study explores OB/GYN providers' knowledge about published health and healthcare disparities in women's reproductive health. METHOD: We collected demographic and health disparities knowledge information from OB/GYN providers who were member ... Full text Link to item Cite

What We Can Do about Maternal Mortality-And How to Do It Quickly

Journal Article Obstetrical and Gynecological Survey · April 1, 2020 Full text Cite

Gestational Weight Gain and Postpartum Depression in Women with Class III Obesity.

Journal Article Am J Perinatol · January 2020 OBJECTIVE: We investigated the association between gestational weight gain (GWG) and postpartum depression (PPD) in women with class III obesity. STUDY DESIGN: This is a retrospective cohort of women with body mass index (BMI) ≥ 40 kg/m2 at entry to care, ... Full text Link to item Cite

Postpartum Weight Loss in Women with Class-III Obesity: Do They Lose What They Gain?

Journal Article Am J Perinatol · January 2020 OBJECTIVE: Excessive gestational weight gain (GWG) increases risk of postpartum weight retention in normal and overweight women but little is known about weight retention in morbidly obese women. We evaluated the impact of GWG on postpartum weight retentio ... Full text Link to item Cite

Nausea and Vomiting

Chapter · January 1, 2020 Nausea and vomiting during pregnancy (NVP) occurs commonly with a prevalence of 50–80% for nausea and up to 50% for vomiting and retching. The pathophysiology of NVP is most likely multifactorial. Hypotheses include psychological factors, evolutionary adap ... Full text Cite

Reproductive health care in America: A story of give and take

Journal Article Contemporary Ob/Gyn · November 1, 2019 Cite

Putting the "M" back in maternal-fetal medicine: A 5-year report card on a collaborative effort to address maternal morbidity and mortality in the United States.

Journal Article Am J Obstet Gynecol · October 2019 The Centers for Disease Control and Prevention have demonstrated continuous increased risk for maternal mortality and severe morbidity with racial disparities among non-Hispanic black women an important contributing factor. More than 50,000 women experienc ... Full text Link to item Cite

Increased Rwandan Access to Obstetrician-Gynecologists Through a U.S.-Rwanda Academic Training Partnership.

Journal Article Obstet Gynecol · July 2019 OBJECTIVE: To evaluate the first 5 years of the Human Resources for Health Rwanda program from the program onset in the July 2012-2016 academic years, and its effects on access to care through examination of: 1) the number of trained obstetrician-gynecolog ... Full text Link to item Cite

Race and breastfeeding in the American South

Journal Article Contemporary Ob/Gyn · March 1, 2019 Cite

Redefining postpartum care

Journal Article Contemporary Ob/Gyn · January 1, 2019 Cite

The First National Summit on Women's Health: The Future of Obstetrics and Gynecology Training.

Journal Article Obstet Gynecol · September 2018 OBJECTIVE: To identify the current challenges in obstetrics and gynecology residency education and propose solutions to overcome these obstacles. METHODS: The American College of Obstetricians and Gynecologists (ACOG) hosted the first National Summit on Wo ... Full text Link to item Cite

Reduction of Peripartum Racial and Ethnic Disparities: A Conceptual Framework and Maternal Safety Consensus Bundle.

Journal Article J Obstet Gynecol Neonatal Nurs · May 2018 Racial and ethnic disparities exist in both perinatal outcomes and health care quality. For example, Black women are three to four times more likely to die from pregnancy-related causes and have more than a twofold greater risk of severe maternal morbidity ... Full text Link to item Cite

Reduction of Peripartum Racial and Ethnic Disparities: A Conceptual Framework and Maternal Safety Consensus Bundle.

Journal Article J Midwifery Womens Health · May 2018 Racial and ethnic disparities exist in both perinatal outcomes and health care quality. For example, black women are 3 to 4 times more likely to die from pregnancy-related causes and have more than a 2-fold greater risk of severe maternal morbidity than wh ... Full text Link to item Cite

Reduction of Peripartum Racial and Ethnic Disparities: A Conceptual Framework and Maternal Safety Consensus Bundle.

Journal Article Obstet Gynecol · May 2018 Racial and ethnic disparities exist in both perinatal outcomes and health care quality. For example, black women are three to four times more likely to die from pregnancy-related causes and have more than a twofold greater risk of severe maternal morbidity ... Full text Link to item Cite

Health Care Disparity and Pregnancy-Related Mortality in the United States, 2005-2014.

Journal Article Obstet Gynecol · April 2018 OBJECTIVE: To quantitate the contribution of various demographic factors to the U.S. maternal mortality ratio. METHODS: This was a retrospective observational study. We analyzed data from the Centers for Disease Control and Prevention (CDC) National Center ... Full text Link to item Cite

SMFM Special Report: Putting the "M" back in MFM: Addressing education about disparities in maternal outcomes and care.

Journal Article Am J Obstet Gynecol · February 2018 At the 36th Annual meeting of the Society for Maternal-Fetal Medicine (SMFM), leaders in the field of maternal-fetal medicine (MFM) convened to address maternal outcome and care inequities from 3 perspectives: (1) education, (2) clinical care, and (3) rese ... Full text Link to item Cite

Preconception care

Chapter · January 1, 2018 The primary aim of preconception and interconception care is to improve maternal health and birth outcome for mother, infant and family through prevention and interventions. Preconception care is defined by interventions that aim to identify and modify bio ... Full text Cite

Quality and Safety in Obstetrics and Gynecology.

Journal Article Clin Obstet Gynecol · December 2017 The discipline of obstetrics and gynecology has been a leader for quality and safety in women's health for decades. Obstetrics is the leading cause for admissions, triage, and hospital discharge with over 4 million hospitalizations for births annually. App ... Full text Link to item Cite

Infant Mortality Lessons Learned from a Fetal and Infant Mortality Review Program.

Journal Article Matern Child Health J · December 2017 UNLABELLED: Objective To review fetal and infant deaths from women enrolled in Indianapolis Healthy Start using the National Fetal and Infant Mortality Review (FIMR) methods to provide strategies for prevention. METHODS: Marion County Public Health Departm ... Full text Link to item Cite

Quality measures in high-risk pregnancies: Executive Summary of a Cooperative Workshop of the Society for Maternal-Fetal Medicine, National Institute of Child Health and Human Development, and the American College of Obstetricians and Gynecologists.

Journal Article Am J Obstet Gynecol · October 2017 Providers perceive current obstetric quality measures as imperfect and insufficient. Our organizations convened a "Quality Measures in High-Risk Pregnancies Workshop." The goals were to (1) review the current landscape regarding quality measures in obstetr ... Full text Link to item Cite

Trends in Obstetrician-Gynecologist Visits.

Journal Article Obstet Gynecol · October 2017 Full text Link to item Cite

Global disparities in maternal morbidity and mortality.

Journal Article Semin Perinatol · August 2017 The disparity in maternal mortality for African American women remains one of the greatest public health inequities in the United States (US). To better understand approaches toward amelioration of these differences, we examine settings with similar dispar ... Full text Link to item Cite

The Maternal Health Compact.

Journal Article N Engl J Med · April 6, 2017 Full text Link to item Cite

The poor will always be with us, and they want and need healthcare

Journal Article Contemporary Ob/Gyn · April 1, 2017 Cite

Postpartum hemorrhage

Chapter · January 1, 2017 Traditionally, postpartum hemorrhage (PPH) is defined as blood loss in excess of 500 mL after a vaginal delivery and greater than 1000 mL following a cesarean delivery. Severe hemorrhage is the most common cause of maternal death worldwide accounting for a ... Full text Cite

The Bakri tamponade balloon as an adjunct treatment for refractory postpartum hemorrhage.

Journal Article Int J Gynaecol Obstet · December 2016 OBJECTIVE: To evaluate the Bakri tamponade balloon as an adjunct treatment for refractory postpartum hemorrhage (PPH). METHODS: A prospective observational intervention study was conducted between January 1, 2013, and May 31, 2015, at Great Lakes Hospital ... Full text Link to item Cite

Health Care Disparity and State-Specific Pregnancy-Related Mortality in the United States, 2005-2014.

Journal Article Obstet Gynecol · October 2016 OBJECTIVE: To investigate factors associated with differential state maternal mortality ratios and to quantitate the contribution of various demographic factors to such variation. METHODS: In a population-level analysis study, we analyzed data from the Cen ... Full text Link to item Cite

Seatbelt use during pregnancy.

Journal Article Am J Emerg Med · February 2016 Full text Link to item Cite

Nausea and vomiting of pregnancy

Journal Article Contemporary Ob/Gyn · January 1, 2016 Cite

Well-Woman Task Force: Components of the Well-Woman Visit.

Conference Obstet Gynecol · October 2015 The Patient Protection and Affordable Care Act of 2010 includes strong well-woman health care provisions as a means of optimizing preventive health care across a woman's lifetime. In 2013, The American College of Obstetricians and Gynecologists convened a ... Full text Link to item Cite

Increase in Cesarean Operative Time Following Institution of the 80-Hour Workweek.

Journal Article J Grad Med Educ · September 2015 BACKGROUND: In 2003, the Accreditation Council for Graduate Medical Education limited resident duty hours to 80 hours per week. More than a decade later, the effect of the limits on resident clinical competence is not fully understood. OBJECTIVE: We sought ... Full text Link to item Cite

Balancing cost and benefit in antepartum fetal surveillance

Journal Article Contemporary Ob/Gyn · January 1, 2015 Antenatal fetal surveillance has stood the test of time with regard to the goal of preventing stillbirth in the fetus at risk based on indications for testing. As such, the additional cost for testing in the appropriate setting appears to have benefit. How ... Cite

Medical and obstetric complications among pregnant women aged 45 and older.

Journal Article PLoS One · 2014 OBJECTIVE: The number of women aged 45 and older who become pregnant is increasing. The objective of this study was to estimate the risk of medical and obstetric complications among women aged 45 and older. METHODS: The Nationwide Inpatient Sample was used ... Full text Open Access Link to item Cite

GDM: Focus on decreasing morbidity

Journal Article Contemporary Ob/Gyn · January 1, 2014 Cite

Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion.

Journal Article Reprod Sci · January 2014 Smoking in pregnancy reduces preeclampsia risk, but the mechanism of this effect is unknown. Prior studies have demonstrated that women with preeclampsia have lower placental adrenomedullin (AM) expression, and cigarette smoke extract (CSE) treatment of pl ... Full text Link to item Cite

GBS screening: An update on guidelines and methods

Journal Article Contemporary Ob/Gyn · December 1, 2013 Great advances have been made in preventing neonatal GBS sepsis of both early and late onset. despite recommendations, however, screening is not universal or uniform. ... Cite

The life course theory: Are public health programs the answer to racial disparities in prematurity and infant mortality?

Journal Article Contemporary Ob/Gyn · December 1, 2013 The implications of chronic risk factors on pregnancy outcome and disease expression are striking. The traditional medical model has often focused on individual health knowledge and access to the healthcare system to mitigate specific risk factors. But LCT ... Cite

Predictors of failed trial of labor among women with an extremely obese body mass index.

Journal Article Am J Obstet Gynecol · December 2013 OBJECTIVE: The purpose of this study was to examine predictors associated with cesarean delivery (CD) among extremely obese women undergoing a trial of labor (TOL). STUDY DESIGN: Using a delivery database, we identified all pregnant women delivering at our ... Full text Link to item Cite

Perinatal implications of motor vehicle accident trauma during pregnancy: identifying populations at risk.

Journal Article Am J Obstet Gynecol · June 2013 OBJECTIVE: The purpose of this study was to examine the association between restraint use, race, and perinatal outcome after motor vehicle accidents (MVAs) during pregnancy. STUDY DESIGN: The Duke Trauma Registry and medical records were searched for infor ... Full text Link to item Cite

Putting the "M" back in maternal-fetal medicine.

Journal Article Am J Obstet Gynecol · June 2013 Although maternal death remains rare in the United States, the rate has not decreased for 3 decades. The rate of severe maternal morbidity, a more prevalent problem, is also rising. Rise in maternal age, in rates of obesity, and in cesarean deliveries as w ... Full text Link to item Cite

DNA methylation at imprint regulatory regions in preterm birth and infection.

Journal Article Am J Obstet Gynecol · May 2013 OBJECTIVE: To aid in understanding long-term health consequences of intrauterine infections in preterm birth, we evaluated DNA methylation at 9 differentially methylated regions that regulate imprinted genes by type of preterm birth (spontaneous preterm la ... Full text Link to item Cite

Smoking and marijuana use in pregnancy.

Journal Article Clin Obstet Gynecol · March 2013 The obstetrical, neonatal, and childhood risk associated with prenatal smoking are well known. Prenatal smoking has been implicated in up to 25% of low birth weight infants primarily from preterm birth and fetal growth restriction and up to 10% of all infa ... Full text Link to item Cite

Hypertensive disease in pregnancy: an examination of ethnic differences and the Hispanic paradox.

Journal Article J Neonatal Perinatal Med · 2013 OBJECTIVE: The "Hispanic paradox" refers to the epidemiological finding that Hispanics in the US have better health outcomes than the average population despite what their aggregate socioeconomic determinants would predict. The aim of this study was to eva ... Full text Link to item Cite

Obstetricians' role critical in increasing patients' access to cord blood

Journal Article Contemporary Ob/Gyn · October 26, 2012 Cite

Informing the patient and the community about the implications of primary cesarean.

Journal Article Semin Perinatol · October 2012 Education of patients and the community should begin with an acknowledgment of the increase in primary and secondary morbidity and mortality associated with the initial cesarean delivery. Women with cesarean birth have a higher rate of rehospitalization fo ... Full text Link to item Cite

Cervical dilation as a predictor of pregnancy outcome following emergency cerclage.

Journal Article J Matern Fetal Neonatal Med · October 2012 OBJECTIVE: To determine whether cervical dilation at the time of physical examination indicated cerclage placement can predicts latency and gestational age at delivery. METHODS: A retrospective cohort study of all women who underwent physical examination i ... Full text Link to item Cite

The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin.

Journal Article Reprod Sci · May 2012 We tested the hypothesis that cigarette smoke extract (CSE) leads to differences in expression of genes involved in angiogenesis and affects cell viability and migration in a first-trimester cytotrophoblast cell line (HTR-8/SVneo). HTR-8/SVneo cells were t ... Full text Link to item Cite

The role of the maternal-fetal medicine subspecialist in review and prevention of maternal deaths.

Journal Article Semin Perinatol · February 2012 The maternal-fetal medicine subspecialist plays a critical role in the evaluation and management of women with obstetrical and medical comorbidities. These women have a higher risk for obstetrical morbidity, "near miss," and maternal mortality. Maternal de ... Full text Link to item Cite

Near-miss maternal mortality: cardiac dysfunction as the principal cause of obstetric intensive care unit admissions.

Journal Article Obstet Gynecol · February 2012 OBJECTIVE: Evaluation of "near-miss" maternal mortality is a robust surveillance method to assess the quality of obstetric care and determinants of poor maternal outcome. To evaluate near-miss maternal mortality, we examined patient characteristics and mat ... Full text Link to item Cite

The impact of prenatal education on behavioral changes toward breast feeding and smoking cessation in a healthy start population.

Journal Article J Natl Med Assoc · 2012 PURPOSE: To evaluate the impact of prenatal education by case managers on 2 social determinants of health behaviors-breast feeding and smoking cessation-among participants enrolled in Indianapolis Healthy Start (IHS). METHOD: Birth and death data up to 1 y ... Full text Link to item Cite

Preventing folic acid deficiency in women of childbearing age

Journal Article Giornale Italiano di Ostetricia e Ginecologia · July 1, 2011 Cite

Near miss maternal mortality in a multiethnic population.

Journal Article Ann Epidemiol · February 2011 PURPOSE: To determine the impact of ethnicity on "near miss"/severe obstetric morbidity in a multi-ethnic, tertiary care population. METHODS: We carried out a cross-sectional analysis using birth data for 12,774 women with Medicaid who gave birth between J ... Full text Link to item Cite

Closing the folate gap in reproductive-age women

Journal Article Contemporary Ob/Gyn · December 1, 2010 Cite

Health disparities in risk for cervical insufficiency.

Journal Article Hum Reprod · November 2010 BACKGROUND: The purpose of the study was to examine racial/ethnic differences in cervical insufficiency risk. METHODS: We used the US 2005 Natality data file. Analysis was limited to singleton births. The prevalence of cervical insufficiency was examined b ... Full text Link to item Cite

Eligibility and accessibility of magnetic resonance-guided focused ultrasound (MRgFUS) for the treatment of uterine leiomyomas.

Journal Article Fertil Steril · October 2010 OBJECTIVE: To evaluate patient eligibility and accessibility of magnetic resonance-guided focused ultrasound (MRgFUS) for women with symptomatic uterine leiomyomas who desire conservative therapy. DESIGN: Retrospective analysis of 169 patients referred for ... Full text Link to item Cite

Racial diversity in uterine leiomyoma clinical studies.

Journal Article Fertil Steril · September 2010 OBJECTIVE: To examine racial diversity in clinical studies on uterine leiomyomas included in a review of evidence-based practice because of the disproportionate burden of fibroids in Black women. DESIGN: Review of 106 studies cited in the Agency for Health ... Full text Link to item Cite

Cervicovaginal fistula presenting during miscarriage.

Journal Article Ultrasound Obstet Gynecol · July 2010 Cervicovaginal fistula is a recognized complication of induced mid-trimester termination of pregnancy, but more recently it has also been recognized as representing a complication of prior cervical cerclage. We report the ultrasound findings of prolapse of ... Full text Link to item Cite

Deep vein thrombosis and pulmonary embolism in pregnancy: diagnosis, complications, and management.

Journal Article Clin Obstet Gynecol · June 2010 Venous thromboembolism is a leading cause for maternal mortality. Because of the increase risk for thromboembolism in pregnancy and the postpartum period, the clinician must be on high alert for the signs and symptoms and use appropriate diagnostics in a t ... Full text Link to item Cite

Weight gain recommendations in pregnancy and the obesity epidemic.

Journal Article Obstet Gynecol · January 2010 Excessive gestational weight gain and obesity have been recognized as independent risk factors for maternal and fetal complications of pregnancy with significant lifelong consequences. These associations call into question the recently released Institute o ... Full text Link to item Cite

Trauma in pregnancy.

Journal Article Obstet Gynecol · July 2009 Acute traumatic injury during pregnancy is a significant contributor to maternal and fetal morbidity and mortality in the United States. Motor vehicle accidents are the leading cause of injury-related maternal death, followed by violence and assault. Lack ... Full text Link to item Cite

A review of the implications and impact of pregnancy on sexual function

Journal Article Current Sexual Health Reports · March 1, 2008 Conception and pregnancy is viewed as the ultimate expression of intimacy in a couple's sexual relationship. However, pregnancy and the postpartum period are times of significant change for the woman that can interfere with sexuality and sexual desires. Se ... Full text Cite

Air embolism during pregnancy.

Journal Article Obstet Gynecol · February 2008 Featured Publication Full text Link to item Cite

Indoor air pollution from biomass combustion and respiratory symptoms of women and children in a Zimbabwean village.

Journal Article Indoor Air · December 2007 Featured Publication UNLABELLED: Rural areas of developing countries are particularly reliant on biomass for cooking and heating. Women and children in these areas are often exposed to high levels of pollutants from biomass combustion that is associated with a range of respira ... Full text Link to item Cite

Ethical and policy issues relating to progenitor-cell-based strategies for prevention of atherosclerosis.

Journal Article J Med Ethics · November 2007 OBJECTIVE: To examine important ethical and societal issues relating to the use of progenitor-cell-based strategies for disease prevention, particularly atherosclerosis. BACKGROUND: Several nascent lines of evidence suggest the feasibility of using progeni ... Full text Link to item Cite

The "Hispanic paradox": an investigation of racial disparity in pregnancy outcomes at a tertiary care medical center.

Journal Article Am J Obstet Gynecol · August 2007 Featured Publication OBJECTIVE: The purpose of this study was to examine racial disparities and the "Hispanic paradox" in pregnancy outcomes at a tertiary-care medical center. STUDY DESIGN: A cross-sectional study of pregnancy events was performed with information from the Duk ... Full text Link to item Cite

Thromboembolism in pregnancy: recurrence and its prevention.

Journal Article Semin Perinatol · June 2007 Fifteen to 25% of thromboembolic events in pregnancy are recurrent events. Women with a history of thrombosis have a three- to fourfold increased risk of recurrence when they are pregnant compared with when they are not. The risks are even higher postpartu ... Full text Link to item Cite

Double occupancy.

Journal Article Am J Obstet Gynecol · February 2007 Featured Publication Full text Link to item Cite

Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila.

Journal Article Development · January 2006 Featured Publication During metamorphosis, the reorganization of the nervous system of Drosophila melanogaster proceeds in part through remodeling of larval neurons. In this study, we used in-vitro imaging techniques and immunocytochemistry to track the remodeling of the thora ... Full text Link to item Cite

Preventability of pregnancy-related deaths: results of a state-wide review.

Journal Article Obstet Gynecol · December 2005 Featured Publication OBJECTIVE: Although the risk of death from complications of pregnancy in the 20th century has decreased dramatically, several lines of evidence suggest that it has not reached an irreducible minimum. To further reduce pregnancy-related mortality, we must u ... Full text Link to item Cite

A multicenter study to determine motivating factors for residents pursuing obstetrics and gynecology.

Journal Article Am J Obstet Gynecol · November 2005 Featured Publication OBJECTIVE: This study was undertaken to determine why residents choose obstetrics and gynecology. STUDY DESIGN: Applicants to obstetrics and gynecology residency programs were surveyed; a 5-point scale (5 = most important) was used to rate various aspects ... Full text Link to item Cite

CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.

Journal Article J Immunol · October 1, 2005 CTL play a critical role in the control of HIV and SIV. However, intrinsic genetic instability enables these immunodeficiency viruses to evade detection by CTL through mutation of targeted antigenic sites. These mutations can impair binding of viral epitop ... Full text Link to item Cite

HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound.

Journal Article J Clin Invest · February 2005 HIV-specific CD4+ T helper lymphocytes are preferred targets for infection. Although complete interruption of combination antiretroviral therapy (ART) can form part of therapeutic manipulations, there is grave concern that the resumption of viral replicati ... Full text Link to item Cite

CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin.

Journal Article Gut · January 2005 BACKGROUND AND AIMS: Transfer of CD4+CD45RBHi T cells into semi syngeneic immunodeficient mice represents a model of inflammatory bowel disease (IBD). As patients with IBD often suffer from osteopenia, we studied if this T cell transfer in mice results in ... Full text Link to item Cite

Clinical evaluation of affirm VPIII in the detection and identification of Trichomonas vaginalis, Gardnerella vaginalis, and Candida species in vaginitis/vaginosis.

Journal Article Infect Dis Obstet Gynecol · 2004 Featured Publication OBJECTIVE: To compare the Affirm VPIII Microbial Identification Test for detection and identification of Candida species, Gardnerella vaginalis and Trichomonas vaginalis to clinical and microscopic criteria commonly used to diagnose vaginitis. METHODS: Wom ... Full text Link to item Cite

Pulmonary embolism in pregnant patients: fetal radiation dose with helical CT.

Journal Article Radiology · August 2002 Featured Publication PURPOSE: To calculate mean fetal radiation dose from helical chest computed tomography (CT) by using maternal-fetal geometries obtained from healthy pregnant women and to compare the calculated CT doses with the fetal doses reported with scintigraphy. MATE ... Full text Link to item Cite

rHuKGF ameliorates symptoms in DSS and CD4(+)CD45RB(Hi) T cell transfer mouse models of inflammatory bowel disease.

Journal Article Am J Physiol Gastrointest Liver Physiol · April 2002 There is an acute need for effective therapy for inflammatory bowel disease (IBD), particularly at the level of repair of the damaged epithelium. We evaluated the efficacy of recombinant human keratinocyte growth factor (rHuKGF) in both the dextran sodium ... Full text Link to item Cite

Outcome of infants delivered between 24 and 28 weeks' gestation in women with severe pre-eclampsia.

Journal Article J Matern Fetal Med · October 2001 Featured Publication OBJECTIVE: To determine whether there are differences in neonatal outcome between infants born to mothers with severe pre-eclampsia and those born to normotensive mothers with preterm labor and intact membranes between 24 and 28 weeks' gestation. MATERIALS ... Full text Link to item Cite

Evaluation of the Affirm Ambient Temperature Transport System for the detection and identification of Trichomonas vaginalis, Gardnerella vaginalis, and Candida species from vaginal fluid specimens.

Journal Article J Clin Microbiol · September 2001 Featured Publication The objective of this study was to measure the performance of the Affirm Ambient Temperature Transport System (ATTS) over time and to estimate the length of time the system can preserve a vaginal specimen containing the three common organisms causing vagin ... Full text Link to item Cite

Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium.

Journal Article Am J Obstet Gynecol · December 2000 Featured Publication OBJECTIVE: The aim of this study was to compare the distributions of protein kinase C isozymes in human nonpregnant and pregnant myometrial tissues and primary cell cultures. STUDY DESIGN: Myometrial tissues were obtained at hysterectomy from nonpregnant w ... Full text Link to item Cite

Quantitation of the five forms of plasma high molecular weight angiotensinogen in women with pregnancy-induced hypertension.

Journal Article Am J Hypertens · March 2000 Featured Publication In the human pregnant state a high molecular weight form of angiotensinogen (HMrA) is present in significant quantities in addition to the usual low molecular weight angiotensinogen (LMrA). In a previous study involving a small number of white women, it wa ... Full text Link to item Cite

A randomized comparison of home uterine activity monitoring in the outpatient management of women treated for preterm labor.

Journal Article Am J Obstet Gynecol · April 1999 Featured Publication OBJECTIVE: The aim of the study was to evaluate home uterine activity monitoring as an intervention in reducing the rate of preterm birth among women treated for preterm labor. STUDY DESIGN: A total of 186 women were treated in the hospital with magnesium ... Full text Link to item Cite

Outcome of patients undergoing transabdominal cerclage: A descriptive study

Journal Article Journal of Maternal-Fetal and Neonatal Medicine · January 1, 1999 Objective: Transabdominal cerclage is now evolving as an alternative to transvaginal cerclage in patients with cervical incompetence. The purpose of our study was to evaluate and describe our experience in patients selected to undergo transabdominal cercla ... Full text Cite

Effect of cocaine on intracellular calcium regulation in myometrium from pregnant women.

Journal Article J Soc Gynecol Investig · 1999 Featured Publication OBJECTIVE: To evaluate the effect of cocaine on intracellular free calcium ([Ca2+]i) regulation in human myometrial cells by determining the sources of Ca2+ it might mobilize, as well as assess the role cocaine might play in the catecholamine's effect on t ... Full text Link to item Cite

Outcome of patients undergoing transabdominal cerclage: a descriptive study.

Journal Article J Matern Fetal Med · 1999 Featured Publication OBJECTIVE: Transabdominal cerclage is now evolving as an alternative to transvaginal cerclage in patients with cervical incompetence. The purpose of our study was to evaluate and describe our experience in patients selected to undergo transabdominal cercla ... Full text Link to item Cite

Localization of a baculovirus-induced chitinase in the insect cell endoplasmic reticulum.

Journal Article J Virol · December 1998 Featured Publication Confocal immunofluorescence microscopy was used to demonstrate that the Autographa californica nucleopolyhedrovirus (AcMNPV) chitinase was localized within the endoplasmic reticulum (ER) of virus-infected insect cells. This was consistent with removal of t ... Full text Link to item Cite

Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?

Journal Article Am J Obstet Gynecol · November 1998 Featured Publication OBJECTIVE: Our purpose was to determine whether the continuation of antibiotics postoperatively after cesarean section in patients whose labors were complicated by chorioamnionitis would reduce the incidence of endometritis. STUDY DESIGN: Patients with a c ... Full text Link to item Cite

Anticoagulation.

Journal Article Clin Obstet Gynecol · September 1998 Featured Publication Outpatient management of women requiring treatment and prophylaxis against thromboembolic conditions during pregnancy and the postpartum period requires a coordinated effort between the patient, her obstetrician and, in certain cases, a hematologic consult ... Full text Link to item Cite

Methadone maintenance in pregnancy: a reappraisal.

Journal Article Am J Obstet Gynecol · August 1998 Featured Publication OBJECTIVE: The purpose of this study is to evaluate women receiving methadone maintenance during pregnancy. STUDY DESIGN: Thirty-two pregnancies in women receiving methadone maintenance were matched by gestational age to women with a positive urine screen ... Full text Link to item Cite

Cytomegalovirus infection.

Journal Article Semin Perinatol · August 1998 Featured Publication Cytomegalovirus (CMV) infection is the most common perinatal infection and may result in severe injury to the fetus. Forty percent to 50% of infants delivered to mothers with primary CMV will have congenital infections. Of these, 5% to 18% will be overtly ... Full text Link to item Cite

The impact of prenatal care coordination on birth outcome.

Journal Article Prim Care Update Ob Gyns · July 1, 1998 Featured Publication Objective: Care coordination is a Medicaid benefit program designed to assist low-income women in gaining access to pregnancy related services. This study examines the relationship between prenatal care coordination and its impact on access to prenatal ser ... Full text Link to item Cite

A comparative evaluation of the risks and complications of early amniocentesis

Journal Article Prenatal and Neonatal Medicine · April 1, 1998 Objective: The purpose of this report is to present the complications and pregnancy outcome experience for early genetic amniocentesis. Study design: We compared amniocentesis-related complications and pregnancy outcome in singleton gestations of 370 women ... Cite

Effect of cocaine on cytoplasmic calcium and IP3 production in human myometrial cells

Journal Article FASEB Journal · March 20, 1998 Cocaine has ability to increase spontaneous myometrial contractions as well as to potentiate the contractile responses to catecholamines. Because free cytoplasmic calcium concentration ([Ca2+]i) and inositol 1,4,5-trisphosphate (IP3) are important messenge ... Cite

The association of aneuploidy and unexplained elevated maternal serum alpha-fetoprotein.

Journal Article J Perinatol · 1998 Featured Publication OBJECTIVE: The purpose of this study was to examine fetal chromosomal abnormalities in pregnancies complicated by unexplained elevated maternal serum alpha-fetoprotein (MSAFP). STUDY DESIGN: We reviewed, using a computerized database, 58,162 obstetrical ul ... Link to item Cite

Aneuploidy: is cytogenetic evaluation indicated for unexplained elevated maternal serum alpha-fetoprotein?

Journal Article Acta Diabetologica Latina · December 1, 1997 OBJECTIVE: The purpose of this study was to examine the value of fetal karyotyping in pregnancies complicated by unexplained elevated maternal serum alpha-fetoprotein. METHODS: 58,162 obstetrical ultrasounds performed at Indiana University Prenatal Diagnos ... Cite

Illicit drug use by pregnant women in metropolitan, medium sized, and rural counties using meconium sampling

Journal Article Acta Diabetologica Latina · December 1, 1997 OBJECTIVE: The purpose of this study was to compare illicit drug use by pregnant women in metropolitan, medium sized, and rural counties using neonatal meconiurn sampling. METHODS: Twelve counties in Indiana were selected to participate in a statewide anon ... Cite

Sensitivity and specificity of prenatal urine drug screening using national institute of drug abuse cutoff levels with the florescence polarization immunoassay

Journal Article Acta Diabetologica Latina · December 1, 1997 OBJECTIVE: The purpose of this study was to determine the sensitivity and specificity of prenatal urine drug screening with florescence polarization immunoassay (FPIA) using cutoff concentrations specified by the National Institute of Drug Abuse (NIDA). ME ... Cite

Methadone maintenance in pregnancy: A reappraisal

Journal Article Acta Diabetologica Latina · December 1, 1997 OBJECTIVE: The purpose of this study is to compare pregnancy outcome in women receiving inethadone maintenance to women using cocaine and drug free controls. STUDY DESIGN: Thirty-two pregnancies in women receiving methadone maintenance were matched hy gest ... Cite

The effect of cocaine on fetal heart rate tracing during labor

Journal Article Acta Diabetologica Latina · December 1, 1997 OBJECTIVE: To dĂ©termine the characteristics of fetal heart rate tracings during labor in women with recent cocaine use. STUDY DESIGN: Between 11/9;") and 2/96. 25 women were identified from the toxicology and delivery logs .is being positive for cocaine du ... Cite

Tocolytic treatment for preterm contractions with and without cervical changes.

Journal Article Am J Perinatol · August 1997 Featured Publication Our purpose was to evaluate the impact of intravenous and oral tocolysis on prolongation of gestation for women with preterm uterine contractions and/or labor. Candidates for evaluation and treatment including women with contractions between 24 and 35 week ... Full text Link to item Cite

Characterization and application of an avian in vitro spermatozoa-egg interaction assay using the inner perivitelline layer from laid chicken eggs.

Journal Article J Reprod Fertil · July 1997 The inner perivitelline layer, separated from laid chicken eggs, was investigated as readily available material for studying the spermatozoa-egg interaction in vitro. This layer was found to have a similar response to hydrolysis by spermatozoa as the inner ... Full text Link to item Cite

Cervical prolapse complicating pregnancy.

Journal Article J Natl Med Assoc · May 1997 Featured Publication Uterine cervical prolapse concurrent with pregnancy is rare. This article reports three cases of second-degree cervical prolapse during pregnancy. Two women developed prolapse in the late second trimester while one women had preexisting prolapse. Both wome ... Link to item Cite

Cervical ripening: randomized comparison of intravaginal prostaglandin E2 gel with prostaglandin E2 gel plus laminaria tents.

Journal Article J Matern Fetal Med · 1997 Featured Publication The purpose of this study was to evaluate the efficacy of adding laminaria tents to sequential intravaginal prostaglandin E2 (PGE2) gel for cervical ripening. A prospective, randomized study was conducted from October 1994 to May 1995. Pregnant women with ... Full text Link to item Cite

Umbilical cord thiocyanate and thyroid function in intrauterine growth-restricted infants of the smoking gravida.

Journal Article J Perinatol · 1997 Featured Publication OBJECTIVE: We evaluated maternal and umbilical cord thiocyanate and thyroid function in intrauterine growth-restricted infants of smoking mothers. STUDY DESIGN: One hundred six mother-infant pairs were studied and divided into four groups: smokers with app ... Link to item Cite

The impact of the Women, Infants and Children Food Supplement Program on birth outcome.

Journal Article Am J Obstet Gynecol · April 1996 Featured Publication OBJECTIVE: Our purpose was to compare the birth outcomes of pregnant women in the Women, Infants and Children Food Supplement Program with women not in the program. STUDY DESIGN: The vital records of 4713 women, 2895 enrolled in the Women, Infants and Chil ... Full text Link to item Cite

Deep venous thrombosis and pulmonary embolism.

Journal Article Clin Obstet Gynecol · March 1996 Featured Publication Full text Link to item Cite

Effect of magnesium on fetal heart rate variability using computer analysis.

Journal Article Am J Perinatol · July 1995 Featured Publication We studied 16 women, at 32 weeks' or more gestation who required magnesium sulfate (MgSO4) therapy for preterm labor or preeclampsia. A 60-minute Doppler fetal heart rate (FHR) tracing, analyzed by the Oxford Sonicaid System 8000, was obtained for 1 hour b ... Full text Link to item Cite

Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age.

Journal Article Transfusion · July 1995 Featured Publication BACKGROUND: Cord blood has been used for transplantation. The purpose of this study was to compare numbers of hematopoietic progenitors in cord blood collected from neonatal infants who are small for their gestational age and those who are normal. STUDY DE ... Full text Link to item Cite

Antiphospholipid antibodies and recurrent pregnancy loss.

Journal Article Clin Obstet Gynecol · March 1991 Featured Publication Women with antiphospholipid antibodies have a significant risk of reproductive failure and adverse pregnancy outcomes. The incidence of recurrent abortion, fetal death, and intrauterine fetal growth retardation is significant. Women with a history of recur ... Full text Link to item Cite

Anticardiolipin antibodies in unselected pregnant women. Relationship to fetal outcome.

Journal Article J Perinatol · March 1991 Featured Publication Anticardiolipin antibodies (ACLA) have recently been associated with adverse fetal outcome. The prevalence of elevated ACLA has not been studied in unselected pregnant women, however. Twelve hundred unselected pregnant women were screened for IgG ACLA usin ... Link to item Cite

Obstetric complications in young teenagers.

Journal Article South Med J · January 1991 Featured Publication We compared pregnancy outcome in 286 teenaged primigravidas (less than or equal to 16 years old) and 267 adult primigravidas (21 to 25 years old) who had similar prenatal care, socioeconomic status, and racial balance. The incidence of preterm labor and de ... Full text Link to item Cite

Clinical chorioamnionitis is not predicted by an ultrasonic biophysical profile in patients with premature rupture of membranes.

Journal Article Obstet Gynecol · December 1990 Featured Publication A modified biophysical profile was assessed serially in 47 patients with premature rupture of membranes who were not in labor. This profile included fetal movement, fetal tone, fetal breathing, amniotic fluid volume, and placental grade. The most recent st ... Link to item Cite

Umbilical cord blood gas assessment of twins.

Journal Article Obstet Gynecol · May 1990 Featured Publication Umbilical cord arterial and venous blood gas values were compared in 63 twin pairs, of which 57 pairs had birth weights of 1500 g or more each. Small differences between the first and second twins existed for PO2, PCO2, and pH. However, bicarbonate values ... Link to item Cite

Umbilical cord blood gases for term healthy newborns.

Journal Article Am J Perinatol · April 1990 Featured Publication Examination of paired umbilical arterial and umbilical venous blood gases for 147 term, healthy newborns revealed a strong correlation of pH, bicarbonate, and base excess with the 1-minute Apgar score. Although significantly different from each other, a st ... Full text Link to item Cite

Varicella complicating pregnancy

Journal Article Infections in Medicine · January 1, 1990 Cite

Strategic planning.

Journal Article AAOHN J · July 1989 Featured Publication Link to item Cite

Estimating fetal weight in patients with preterm premature rupture of the membranes.

Journal Article Am J Obstet Gynecol · May 1989 Featured Publication Fetal weight estimation was performed in 58 women with preterm premature rupture of the membranes within 4 days of delivery. Of twelve formulas evaluated, only two met the requirements for clinical use (i.e., they had a small mean percent error and a high ... Full text Link to item Cite

Fetal anthropometry at term: effect of menstrual age and relative fetal size.

Journal Article J Clin Ultrasound · 1989 Featured Publication In a study of 324 term pregnancies, fetal measurements (biparietal diameter, femur length, and abdominal diameter) obtained within one week of delivery correlated more strongly with relative birth weight than with menstrual age. ... Full text Link to item Cite

In utero growth of the large-for-menstrual-age fetus.

Journal Article J Clin Ultrasound · January 1989 Featured Publication In a cross-sectional study of 87 large-for-menstrual-age term infants, intrauterine growth was found to be linear, 34 g per day. Differences between diabetic and nondiabetic pregnancies were not evident. ... Full text Link to item Cite

Estimating fetal weight in patients with preterm premature rupture of the membranes

Journal Article American Journal of Obstetrics and Gynecology · 1989 Fetal weight estimation was performed in 58 women with preterm premature rupture of the membranes within 4 days of delivery. Of twelve formulas evaluated, only two met the requirements for clinical use (i.e., they had a small mean percent error and a high ... Cite

Ultrasonographic identification of the macrosomic fetus.

Journal Article Am J Obstet Gynecol · November 1988 Featured Publication Ultrasonographically determined biparietal diameter, femur length, abdominal circumference, and estimated fetal weight were analyzed with regard to their ability to predict the macrosomic newborn. Receiver operating characteristic curves were plotted for e ... Full text Link to item Cite

Fetal weight estimates in diabetic gravid women.

Journal Article J Clin Ultrasound · October 1988 Featured Publication Fetal weight in utero was estimated sonographically within one week of delivery in 70 live-born fetuses of diabetic gravidas. The best estimates of weight were obtained with formulas dependent on biparietal diameter, abdominal circumference, and femur diap ... Full text Link to item Cite

Fetal overgrowth. Diabetic versus nondiabetic.

Journal Article J Ultrasound Med · October 1988 Featured Publication Term, large for gestational aged newborns were retrospectively evaluated. The fetal parameter of relative growth, was measured using the ratio of fetal length to abdominal circumference (FL/AC). This measurement was not different between diabetic and nondi ... Full text Link to item Cite

Premature placental calcification in maternal cigarette smokers.

Journal Article Obstet Gynecol · June 1988 Featured Publication Ultrasonographic examinations, including placental grading, were done in 145 smoking and 100 nonsmoking low-risk obstetric patients at 37 weeks' gestation. Extensive calcification--grade III changes--occurred significantly more often in smokers than in non ... Link to item Cite

Estimated fetal weight: applicability to small- and large-for-gestational-age fetus.

Journal Article J Clin Ultrasound · February 1988 Featured Publication Ultrasonic formulas using femur length and abdominal circumference with or without biparietal diameter were found to be highly accurate in predicting the weight of normal-sized term infants. The small-for-gestational age fetus, however, was overestimated a ... Full text Link to item Cite

Premature placental calcification in maternal cigarette smokers

Journal Article Obstetrics and Gynecology · January 1, 1988 Ultrasonographic examinations, including placental grading, were done in 145 smoking and 100 nonsmoking low- risk obstetric patients at 37 weeks’ gestation. Extensive calcification-grade III changes-occurred significantly more often in smokers than in nons ... Cite

The relationship of placental grade to fetal size and growth at term.

Journal Article Am J Perinatol · January 1988 Featured Publication Among 246 term patients undergoing ultrasonic evaluation within 1 week of delivery, a grade-three placenta was found in 39.4%. Advanced placental maturity was not associated with altered fetal growth rates or an increase in small- or large-for-gestational ... Full text Link to item Cite

Premature placental calcification in maternal cigarette smokers

Journal Article Obstetrics and Gynecology · 1988 Ultrasonographic examinations, including placental grading, were done in 145 smoking and 100 nonsmoking low-risk obstetric patients at 37 weeks' gestation. Extensive calcification - grade III changes - occurred significantly more often in smokers than in n ... Cite

Ultrasonic recognition of the small-for-gestational-age fetus.

Journal Article Obstet Gynecol · April 1987 Featured Publication Sonar biparietal diameter, femur length, abdominal circumference, femur length/abdominal circumference ratio, ponderal index, and estimated fetal weight were obtained within ten days of delivery of small-for-gestational-age (SGA) (N = 102) and non-SGA (N = ... Link to item Cite

Recognition of the overgrown fetus: in utero ponderal indices.

Journal Article Am J Perinatol · April 1987 Featured Publication In a cross-sectional study of 210 pregnancies resulting in above-average-sized term infants, ponderal and ponderal-like indices were found to be highly correlative with fetal overgrowth. Clinical usefulness, however, is limited because for each index, most ... Full text Link to item Cite

Plasma and amniotic fluid prostacyclin and thromboxane in mild pregnancy-induced hypertension.

Journal Article Am J Perinatol · April 1987 Featured Publication To study the involvement of 6 keto prostaglandin F1 alpha (6 keto PGF1 alpha) and thromboxane B2 (TxB2) in mild pregnancy-induced hypertension (PIH), we measured amniotic fluid and plasma concentration of these prostanoids by radioimmunoassay in PIH subjec ... Full text Link to item Cite

A cross-sectional study of in utero growth of the above average sized fetus.

Journal Article Am J Obstet Gynecol · November 1986 Featured Publication In a cross-sectional study of 210 pregnancies resulting in above-average-sized term infants, biparietal diameter, femur length, and abdominal circumference were found to differ among three birth weight percentile groups (greater than 90, 76 to 90, and 51 t ... Full text Link to item Cite

Leprosy in a mangabey monkey--naturally acquired infection.

Journal Article Int J Lepr Other Mycobact Dis · March 1985 Naturally acquired leprosy was detected in an otherwise normal "sooty" mangabey monkey (Cercocebus atys). This animal was imported from West Africa in 1975 and developed clinical symptoms of leprosy in 1979. Histopathologic findings were those of subpolar- ... Link to item Cite

Adverse drug reactions.

Journal Article Arch Intern Med · August 1983 Link to item Cite

Evidence for polymorphonuclear-leucocyte-derived proteinases in arthritic cartilage.

Journal Article Biochem J · January 1, 1981 1. An enzyme that degrades proteoglycan at neutral pH was extracted with 4 M-guanidine hydrochloride from the articular cartilage of rabbits with antigen-induced arthritis. 2. The enzyme had an apparent molecular weight on Ultrogel AcA 54 of about 8000 and ... Full text Link to item Cite

Control of proteoglycan synthesis. Studies on the activation of synthesis observed during culture of articular cartilages.

Journal Article Biochem J · April 15, 1980 When slices of adult rabbit articular cartilage were incubated in culture medium, the rate of incorporation of [35S]sulphate or [3H]acetate into glycosaminoglycans increased 4-8 fold during the first 5 days of incubation. Similar changes in biosynthetic ac ... Full text Link to item Cite

Antigen-induced arthritis. Studies on the inhibition of proteoglycan synthesis observed in articular cartilage during short-term joint inflammation.

Journal Article Arthritis Rheum · April 1980 During the acute phase of antigen-induced arthritis, cartilage was obtained from five different sites within the joint, and chondrocyte activity was assessed by autoradiography of sections labeled with 35S-sulfate. There was a marked inhibition of chondroc ... Full text Link to item Cite

Degradation of proteoglycan in articular cartilage.

Journal Article Biochim Biophys Acta · November 1, 1978 Adult rabbit articular cartilage was labelled in vivo over 48 h with [35S]sulphate and was then incubated in organ culture at pH 7.2. Approx. 65% of the tissue content of [35S]proteoglycan was released into the culture medium during the first 48 h of incub ... Full text Link to item Cite

Antigen-induced arthritis. Decreased proteoglycan content and inhibition of proteoglycan synthesis in articular cartilage.

Journal Article Arthritis Rheum · 1978 An arthritis was induced in rabbits immunized with human serum albumin by injection of antigen into the hind knee joint. Histological changes in the synovial membrane and an increase in polymorphonuclear granulocytes in the synovial fluid indicated an infl ... Full text Link to item Cite

Onchocercal dermatitis: ultrastructural studies of microfilariae and host tissues, before and after treatment with diethylcarbamazine (Hetrazan).

Journal Article Am J Trop Med Hyg · January 1976 Specimens of skin from four Cameroon patients with severe onchocercal dermatitis, before and after treatment with diethylcarbamazine (DEC), were studied by light and electron microscopy. Microfilariae of Onchocerca volvulus have ultrastructural features re ... Full text Link to item Cite

Hepatitis B antigen in saliva, urine, and stool.

Journal Article Infect Immun · January 1975 A survey of hepatitis B patients, asymptomatic hepatitis B antigen (HBsAg) carriers, and control subjects was conducted to determine the relationship between antigenemia and antigen excretion in saliva, urine, and stool. Radioimmunoassay was used to detect ... Full text Link to item Cite