Scholars@Duke
James Gerard Jollis

James Gerard Jollis

Adjunct Professor in the Department of Medicine
Medicine, Cardiology
james.jollis@duke.edu
Duke Box 3254, Durham, NC 27710
Box 3254 DUMC, Durham, NC 27710

Selected Publications

Diagnostic accuracy of coronary artery calcium for obstructive disease: results from the ACCURACY trial.

Journal Article Int J Cardiol · June 20, 2013 BACKGROUND: Although numerous trials have demonstrated the diagnostic accuracy of coronary artery calcium (CAC) scanning for prediction of obstructive disease, virtually all studies have been performed using Electron Beam CT (EBCT). We evaluated the diagno ... Full text Link to item Cite

Comparison of need for operative therapy in patients with mitral valve prolapse involving both leaflets versus posterior leaflet only.

Journal Article Am J Cardiol · November 1, 2012 Mitral valve prolapse may involve 1 leaflet or 2 leaflets, yet management guidelines do not differentiate posterior leaflet (PML) from bileaflet (BML) prolapse. We hypothesized that patients with BML have a prolonged natural history with more severe atrial ... Full text Link to item Cite

Transport time and care processes for patients transferred with ST-segment-elevation myocardial infarction: the reperfusion in acute myocardial infarction in Carolina emergency rooms experience.

Journal Article Circ Cardiovasc Interv · August 1, 2012 BACKGROUND: For patients with ST-segment elevation myocardial infarction transferred for primary percutaneous coronary intervention, guidelines have called for device activation within 90 minutes of initial presentation. Fewer than 20% of transferred patie ... Full text Link to item Cite

Expansion of a regional ST-segment-elevation myocardial infarction system to an entire state.

Journal Article Circulation · July 10, 2012 BACKGROUND: Despite national guidelines calling for timely coronary artery reperfusion, treatment is often delayed, particularly for patients requiring interhospital transfer. METHODS AND RESULTS: One hundred nineteen North Carolina hospitals developed coo ... Full text Link to item Cite

Systems of care for ST-segment-elevation myocardial infarction: a report From the American Heart Association's Mission: Lifeline.

Journal Article Circ Cardiovasc Qual Outcomes · July 1, 2012 BACKGROUND: National guidelines call for participation in systems to rapidly diagnose and treat ST-segment-elevation myocardial infarction (STEMI). In order to characterize currently implemented STEMI reperfusion systems and identify practices common to sy ... Full text Link to item Cite

Treatment pathways and quality improvement for patients with acute myocardial infarction at a tertiary care center.

Journal Article Crit Pathw Cardiol · June 2012 The timely diagnosis and treatment of acute ST-segment elevation myocardial infarction (STEMI) have become paramount to improving outcomes in this population. Many states, including North Carolina, have established systems to guide regional emergency provi ... Full text Link to item Cite

Effects of atrial fibrillation on treatment of mitral regurgitation in the EVEREST II (Endovascular Valve Edge-to-Edge Repair Study) randomized trial.

Journal Article J Am Coll Cardiol · April 3, 2012 OBJECTIVES: The purpose of this study was to characterize patients with mitral regurgitation (MR) and atrial fibrillation (AF) treated percutaneously using the MitraClip device (Abbott Vascular, Abbott Park, Illinois) and compare the results with surgery i ... Full text Link to item Cite

Rates of cardiac catheterization cancelation for ST-segment elevation myocardial infarction after activation by emergency medical services or emergency physicians: results from the North Carolina Catheterization Laboratory Activation Registry.

Journal Article Circulation · January 17, 2012 BACKGROUND: For patients with an acute ST-segment elevation myocardial infarction, cardiac catheterization laboratory (CCL) activation by emergency medical technicians or emergency physicians has been shown to substantially reduce treatment times. One draw ... Full text Link to item Cite

Clinical application of cine-MRI in the visual assessment of mitral regurgitation compared to echocardiography and cardiac catheterization.

Journal Article PLoS One · 2012 BACKGROUND: Detecting and quantifying the severity of mitral regurgitation is essential for risk stratification and clinical decision-making regarding timing of surgery. Our objective was to assess specific visual parameters by cine-magnetic resonance imag ... Full text Link to item Cite

Care processes associated with quicker door-in-door-out times for patients with ST-elevation-myocardial infarction requiring transfer: results from a statewide regionalization program.

Journal Article Circ Cardiovasc Qual Outcomes · July 2011 BACKGROUND: The ability to rapidly identify patients with ST-segment elevation-myocardial infarction (STEMI) at hospitals without percutaneous coronary intervention (PCI) and transfer them to hospitals with PCI capability is critical to STEMI regionalizati ... Full text Link to item Cite

Association of door-in to door-out time with reperfusion delays and outcomes among patients transferred for primary percutaneous coronary intervention.

Journal Article JAMA · June 22, 2011 CONTEXT: Patients with ST-elevation myocardial infarction (STEMI) requiring interhospital transfer for primary percutaneous coronary intervention (PCI) often have prolonged overall door-to-balloon (DTB) times from first hospital presentation to second hosp ... Full text Link to item Cite

Impact of early surgery on survival of patients with severe mitral regurgitation.

Journal Article Heart · February 2011 BACKGROUND: Optimal timing of surgery in degenerative mitral regurgitation (MR) remains a controversial topic. The impact of current ACC/AHA guideline recommendations about optimal timing of surgery on outcomes is untested and contemporary data are lacking ... Full text Link to item Cite

Impact of a statewide ST-segment-elevation myocardial infarction regionalization program on treatment times for women, minorities, and the elderly.

Journal Article Circ Cardiovasc Qual Outcomes · September 2010 BACKGROUND: Prior studies have demonstrated differences in time to reperfusion for ST-segment-elevation myocardial infarction (STEMI) in women, minorities, and the elderly, relative to their counterparts. Regionalization has been shown to improve overall S ... Full text Link to item Cite

Mitral gradients and frequency of recurrence of mitral regurgitation after ring annuloplasty for ischemic mitral regurgitation.

Journal Article Ann Thorac Surg · October 2009 BACKGROUND: Undersized ring annuloplasty and surgical revascularization are commonly used to correct ischemic mitral regurgitation (MR), but published series have failed to demonstrate a benefit compared with revascularization alone. We hypothesized that s ... Full text Link to item Cite

Certificate of Need (CON) for cardiac care: controversy over the contributions of CON.

Journal Article Health Serv Res · April 2009 OBJECTIVES: To test whether state Certificate of Need (CON) regulations influence procedural mortality or the provision of coronary artery bypass graft surgery (CABG) and percutaneous coronary interventions (PCI). DATA SOURCES: Medicare inpatient claims ob ... Full text Link to item Cite

Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial.

Journal Article J Am Coll Cardiol · November 18, 2008 OBJECTIVES: The purpose of this study was to evaluate the diagnostic accuracy of electrocardiographically gated 64-multidetector row coronary computed tomographic angiography (CCTA) in individuals without known coronary artery disease (CAD). BACKGROUND: CC ... Full text Link to item Cite

Pannus-related prosthetic valve dysfunction and life-threatening aortic regurgitation.

Journal Article J Heart Valve Dis · November 2008 Prosthetic valve dysfunction is a rare but life-threatening condition. A 66-year-old woman presented with shock 15 years after aortic valve replacement with a tilting-disc valve. Imaging demonstrated severe aortic insufficiency and a fixed-open prosthetic ... Link to item Cite

American Society of Echocardiography Consensus Statement on the Clinical Applications of Ultrasonic Contrast Agents in Echocardiography.

Journal Article J Am Soc Echocardiogr · November 2008 UNLABELLED: ACCREDITATION STATEMENT: The American Society of Echocardiography (ASE) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The ASE designates this educational acti ... Full text Link to item Cite

Echocardiographic risk stratification for early surgery with endocarditis: a cost-effectiveness analysis.

Journal Article Heart · May 2008 BACKGROUND: Despite widespread acceptance of echocardiography for diagnosis of infective endocarditis, few investigators have evaluated its utility as a risk-stratification tool to aid therapeutic decision-making. METHODS: A decision tree and Markov analys ... Full text Link to item Cite

Impact of heart failure on patients undergoing major noncardiac surgery.

Journal Article Anesthesiology · April 2008 BACKGROUND: Changes in the demographics and epidemiology of patients with cardiovascular comorbidities who undergo major noncardiac surgery require an updated assessment of which patients are at greater risk of mortality or readmission. The authors evaluat ... Full text Link to item Cite

Tardy Pardee: moving medical effectiveness to the forefront.

Journal Article JACC Cardiovasc Interv · February 2008 Full text Link to item Cite

Implementation of a statewide system for coronary reperfusion for ST-segment elevation myocardial infarction.

Journal Article JAMA · November 28, 2007 CONTEXT: Despite 2 decades of evidence demonstrating benefits from prompt coronary reperfusion, registries continue to show that many patients with ST-segment elevation myocardial infarction (STEMI) are treated too slowly or not at all. OBJECTIVE: To estab ... Full text Link to item Cite

Deterioration of regional wall motion immediately after coronary artery bypass graft surgery is associated with long-term major adverse cardiac events.

Journal Article Anesthesiology · November 2007 BACKGROUND: Patients undergoing coronary artery bypass graft (CABG) surgery frequently develop wall motion abnormalities diagnosed by intraoperative transesophageal echocardiography. However, the relation between deterioration in wall motion and postoperat ... Full text Link to item Cite

Training cardiovascular specialists in imaging: a curriculum based on fundamental concepts required for multimodal imaging.

Journal Article Am Heart J · November 2007 BACKGROUND: Training cardiovascular (CV) imaging specialists is becoming increasingly complex owing to rapidly emerging technological advances and the growing recognition that single modality training is inefficient and results in suboptimal education and ... Full text Link to item Cite

Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study.

Journal Article Am Heart J · February 2007 BACKGROUND: Although heart failure (HF) afflicts nearly 5 million Americans, the long-term cost of HF care has not been described previously. In a prospective, longitudinal cohort of community-dwelling elderly from 4 regions, we examined the long-term cost ... Full text Link to item Cite

The utility of upper endoscopy in patients with concomitant upper gastrointestinal bleeding and acute myocardial infarction.

Journal Article Dig Dis Sci · December 2006 Patients who present with upper gastrointestinal bleeding (UGIB) in the setting of acute myocardial infarction (AMI) may have suffered an UGIB that subsequently led to an AMI or endured an AMI and subsequently suffered a UGIB as a consequence of anticoagul ... Full text Link to item Cite

Achieving quality in cardiovascular imaging: proceedings from the American College of Cardiology-Duke University Medical Center Think Tank on Quality in Cardiovascular Imaging.

Journal Article J Am Coll Cardiol · November 21, 2006 Cardiovascular imaging has enjoyed both rapid technological advances and sustained growth, yet less attention has been focused on quality than in other areas of cardiovascular medicine. To address this deficit, representatives from cardiovascular imaging s ... Full text Link to item Cite

Reperfusion of acute myocardial infarction in North Carolina emergency departments (RACE): study design.

Journal Article Am Heart J · November 2006 Despite the accumulation of almost 2 decades of data in support of rapid reperfusion therapy for ST-segment elevation myocardial infarction (STEMI), the United States healthcare system still faces serious challenges in providing reperfusion to all eligible ... Full text Link to item Cite

Temporal trends in target vessel revascularization in clinical practice: long-term outcomes following coronary stenting from the Duke Database for Cardiovascular Disease.

Journal Article J Invasive Cardiol · September 2006 OBJECTIVE: We examined outcomes of clinical restenosis and temporal trends in repeat target vessel revascularization (TVR) among a broad, unselected patient population undergoing percutaneous coronary revascularization. BACKGROUND: The extent to which clin ... Link to item Cite

Predicting significant coronary artery disease in patients with left ventricular dysfunction.

Journal Article Am Heart J · August 2006 BACKGROUND: Because coronary artery disease (CAD) is a prevalent comorbidity in patients with low ejection function (EF), a number of patients with heart failure undergo diagnostic cardiac catheterization. The objective of this study was to develop a model ... Full text Link to item Cite

Comparison of long-term (seven year) outcomes among patients undergoing percutaneous coronary revascularization with versus without stenting.

Journal Article Am J Cardiol · May 15, 2006 Coronary stents have markedly improved the short- and intermediate-term safety and efficacy of percutaneous coronary intervention by improving acute gains in luminal dimensions, decreasing abrupt vessel occlusion, and decreasing restenosis, yet the long-te ... Full text Link to item Cite

Costs for heart failure with normal vs reduced ejection fraction.

Journal Article Arch Intern Med · January 9, 2006 BACKGROUND: Among the elderly population, heart failure (HF) with normal ejection fraction (EF) is more common than classic HF with low EF. However, there are few data regarding the costs of HF with normal EF. In a prospective, population-based cohort of e ... Full text Link to item Cite

Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: a report from the International Collaboration on Endocarditis-Merged Database.

Other Scand J Infect Dis · 2006 The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on End ... Full text Link to item Cite

Transesophageal assessment of left atrial thrombus using a 3.3-mm monoplane probe.

Journal Article J Am Soc Echocardiogr · December 2005 OBJECTIVES: Our study was designed to demonstrate that transesophageal echocardiography using a 3.3-mm monoplane probe can accurately evaluate the left atrium for patients with arrhythmias before cardioversion. BACKGROUND: Standard probes cause discomfort ... Full text Link to item Cite

The relation between patients' outcomes and the volume of cardioverter-defibrillator implantation procedures performed by physicians treating Medicare beneficiaries.

Journal Article J Am Coll Cardiol · October 18, 2005 OBJECTIVES: The purpose of this study is to determine if implantable cardioverter-defibrillator (ICD) implantation should be limited to physicians with high procedural volume. BACKGROUND: Expanding indications for ICDs will result in an increasing number o ... Full text Link to item Cite

Evidence-based therapies and mortality in patients hospitalized in December with acute myocardial infarction.

Journal Article Ann Intern Med · October 4, 2005 BACKGROUND: Previous studies suggest that patients hospitalized with acute myocardial infarction (MI) in December have poor outcomes, and some studies have hypothesized that the cause may be the infrequent use of evidence-based therapies during the Decembe ... Full text Link to item Cite

The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography.

Journal Article Clin Cardiol · July 2005 BACKGROUND: Patients with elevated troponin are at high risk of adverse outcomes, future cardiac events, and are more likely to have hemodynamically significant coronary artery stenoses. Elevated troponin T (cTnT) in patients with poor renal function porte ... Full text Link to item Cite

Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II.

Journal Article Ann Intern Med · April 19, 2005 BACKGROUND: The Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II demonstrated that implantable cardioverter defibrillators (ICDs) save lives when used in patients with a history of myocardial infarction (MI) and an ejection fraction of 0.3 ... Full text Link to item Cite

Safety and effectiveness of transdermal nicotine patch in smokers admitted with acute coronary syndromes.

Journal Article Am J Cardiol · April 15, 2005 An analysis of smokers admitted with acute coronary syndrome who received transdermal nicotine therapy and those who did not was performed. Propensity analysis was used to match patients. Transdermal nicotine therapy appears safe and does not have an effec ... Full text Link to item Cite

Dollars and stents: the economics of drug-eluting stents.

Journal Article Am Heart Hosp J · 2005 By averting restenoses, drug-eluting stents (DES) reduce the need for repeat revascularization procedures and improve quality of life. Large, randomized clinical trials including the Sirolimus-Eluting Balloon Expandable Stent in Treatment of Patients With ... Full text Link to item Cite

Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes.

Journal Article JAMA · October 6, 2004 CONTEXT: It is unclear if blood transfusion in anemic patients with acute coronary syndromes is associated with improved survival. OBJECTIVE: To determine the association between blood transfusion and mortality among patients with acute coronary syndromes ... Full text Link to item Cite

Outcomes in heart failure patients after major noncardiac surgery.

Journal Article J Am Coll Cardiol · October 6, 2004 OBJECTIVES: The purpose of this study was to evaluate mortality and readmission rates of heart failure (HF) patients after major noncardiac surgery. BACKGROUND: There is a lack of generalizable outcome data on HF patients undergoing major noncardiac surger ... Full text Link to item Cite

State-mandated continuing medical education and the use of proven therapies in patients with an acute myocardial infarction.

Journal Article J Am Coll Cardiol · July 7, 2004 OBJECTIVES: The purpose of this study was to determine whether state-mandated continuing medical education (CME) requirements affect the use of evidence-based therapies and outcomes in patients with acute myocardial infarction (AMI). BACKGROUND: The Instit ... Full text Link to item Cite

Socioeconomic status and outcome following acute myocardial infarction in elderly patients.

Journal Article Arch Intern Med · May 24, 2004 BACKGROUND: Although the Medicare entitlement provides universal hospital care coverage for elderly Americans, disparities in care processes after acute myocardial infarction still exist. Whether these disparities account for increased mortality among elde ... Full text Link to item Cite

Usefulness of myocardial viability or ischemia in predicting long-term survival for patients with severe left ventricular dysfunction undergoing revascularization.

Journal Article Am J Cardiol · May 15, 2004 In 107 patients with coronary disease and severe left ventricular dysfunction, we examined the prognostic power of viability identified by dobutamine stress echocardiography. At a mean follow-up of 27 months, patients with viable myocardium who underwent r ... Full text Link to item Cite

The prognostic importance of comorbidity for mortality in patients with stable coronary artery disease.

Journal Article J Am Coll Cardiol · February 18, 2004 OBJECTIVES: To identify the prevalent and prognostically important coexisting illnesses among single coronary artery disease (CAD) patients. BACKGROUND: As the population ages, physicians are increasingly required to make decisions concerning patients with ... Full text Link to item Cite

Prognostic usefulness of left ventricular thrombus by echocardiography in dilated cardiomyopathy in predicting stroke, transient ischemic attack, and death.

Journal Article Am J Cardiol · February 15, 2004 Echocardiograms of 290 patients with dilated cardiomyopathy (ejection fraction < or =35%) were reviewed for the presence of left ventricular (LV) apical abnormalities; outcomes of stroke and death were then correlated with the presence of LV thrombus. Duri ... Full text Link to item Cite

Impact of managed care on the treatment, costs, and outcomes of fee-for-service Medicare patients with acute myocardial infarction.

Journal Article Health Serv Res · February 2004 OBJECTIVE: To examine the effects of market-level managed care activity on the treatment, cost, and outcomes of care for Medicare fee-for-service acute myocardial infarction (AMI) patients. DATA SOURCES/STUDY SETTING: Patients from the Cooperative Cardiova ... Full text Link to item Cite

Importance of echocardiography in patients with severe nonischemic heart failure: the second Prospective Randomized Amlodipine Survival Evaluation (PRAISE-2) echocardiographic study.

Journal Article Am Heart J · January 2004 BACKGROUND: Echocardiography is used commonly in clinical practice when caring for patients with heart failure. It is unknown whether the presence of certain findings provides an incremental ability to predict survival beyond the use of baseline clinical f ... Full text Link to item Cite

Medication errors in hospitalized cardiovascular patients.

Journal Article Arch Intern Med · June 23, 2003 BACKGROUND: The Institute of Medicine's report To Err Is Human: Building a Safer Health System recommends pharmacist participation in patient rounds as an immediate approach to reducing medical errors. In the same report and in prior publications, cardiova ... Full text Link to item Cite

Imaging techniques for diagnosis of infective endocarditis.

Journal Article Cardiol Clin · May 2003 Cardiac imaging, specifically echocardiography, has greatly enhanced the ability of clinicians to effectively diagnose and manage IE. Echocardiograms should generally be obtained in all patients suspected of having IE, both to establish the diagnosis and t ... Full text Link to item Cite

The influence of left ventricular hypertrophy on survival in patients with coronary artery disease: do race and gender matter?

Journal Article J Am Coll Cardiol · March 19, 2003 OBJECTIVES: We sought to determine the overall prognostic importance of left ventricular hypertrophy (LVH) among patients with coronary artery disease (CAD), as well as to determine whether this risk varies as a function of race or gender. BACKGROUND: Left ... Full text Link to item Cite

Assessing quality in the cardiac catheterization laboratory.

Journal Article Am Heart Hosp J · 2003 Quality assurance and improvement have increasingly been the focus of health care providers, third-party payers, and patients. Because cardiovascular procedures are common, easily identifiable with claims data, and account for a relatively large proportion ... Full text Link to item Cite

Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies.

Journal Article Am Heart J · December 2002 BACKGROUND: Fenfluramine-derivative diet pills were withdrawn from the market in 1997 because of an association with valvular regurgitation, but subsequent estimates of the prevalence of this condition have varied widely. We systematically reviewed evidenc ... Full text Link to item Cite

Imaging techniques for diagnosis of infective endocarditis.

Journal Article Infect Dis Clin North Am · June 2002 With the ability to structurally characterize cardiac manifestations, echocardiography is used for the diagnosis and management of infective endocarditis. In establishing the diagnosis according to the Duke criteria, the findings of endocardial involvement ... Full text Link to item Cite

Is more better?

Journal Article Am Heart J · May 2002 Full text Link to item Cite

Changing patient characteristics and the effect on mortality in endocarditis.

Journal Article Arch Intern Med · January 14, 2002 BACKGROUND: Limited data exist on recent demographic and microbiological changes in infective endocarditis (IE) and the impact of these changes on patient survival. METHODS: Data were collected from all patients with definite or possible IE at Duke Univers ... Full text Link to item Cite

Cost implications of closure of atrial septal defect.

Journal Article Catheter Cardiovasc Interv · January 2002 We sought to evaluate the relative cost of surgical and device closure of atrial septal defect. Device closure for atrial septal defects is becoming an alternative to surgical closure. We examined the hospital-generated cost data in 13 patients who underwe ... Full text Link to item Cite

Quality of care in percutaneous coronary intervention

Journal Article Cardiovascular Reviews and Reports · January 1, 2002 The assessment of quality is gaining more importance as physicians and hospitals are expected to adhere to standards of quality care. Cardiovascular procedures, such as percutaneous coronary intervention (PCI), lend themselves to quality assessment because ... Cite

Advanced coronary artery disease: Appropriate end points for trials of novel therapies.

Journal Article Am Heart J · November 2001 BACKGROUND: The segment of patients with advanced coronary artery disease, or disease that is not amenable to conventional revascularization therapies, continues to grow. Because the natural history of these patients is less defined, the appropriate end po ... Full text Link to item Cite

Post-myocardial infarction risk stratification in elderly patients.

Journal Article Am Heart J · July 2001 BACKGROUND: The purpose of this study was to examine the use of post-myocardial infarction (MI) risk stratification in the elderly. Although expert panels have recommended risk stratification after MI, limited data are available on whether patients actuall ... Full text Link to item Cite

Association between selective serotonin-reuptake inhibitor therapy and heart valve regurgitation.

Journal Article Am J Cardiol · April 15, 2001 The identification of an association between fenfluramines and valvular disease has raised the possibility of a similar association between another class of medications that increases local levels of serotonin, the selective serotonin-reuptake inhibitors ( ... Full text Link to item Cite

Measuring the effectiveness of medical care delivery.

Journal Article J Am Coll Cardiol · March 15, 2001 Full text Link to item Cite

The progression of fenfluramine-associated valvular heart disease assessed by echocardiography.

Journal Article Ann Intern Med · February 20, 2001 BACKGROUND: An association between the dietary suppressants fenfluramine and dexfenfluramine and valvular heart disease was first described in patients from North Dakota and Minnesota in 1997. Limited data are available on the natural history of this valvu ... Full text Link to item Cite

Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities.

Journal Article Circulation · May 2, 2000 BACKGROUND: The combination of fenfluramine and phentermine was a widely used obesity treatment before the withdrawal of fenfluramine for an association with heart valve regurgitation. The prevalence and clinical significance of regurgitation among patient ... Full text Link to item Cite

Evaluating the potential 'economic attractiveness' of new therapies in patients with non-ST elevation acute coronary syndrome.

Journal Article Pharmacoeconomics · March 2000 OBJECTIVE: To evaluate the relationship between how much a new cardiovascular therapy improves clinical outcomes over current therapies and how much more it can cost while still remaining 'economically attractive'. DESIGN: We developed a decision model to ... Full text Link to item Cite

Cardiology, for what it's worth.

Journal Article Am Heart J · March 2000 Full text Link to item Cite

Calcium channel blockers and mortality in elderly patients with myocardial infarction.

Journal Article Arch Intern Med · October 25, 1999 BACKGROUND: Although calcium channel blockers are a useful therapy in relieving angina, lowering blood pressure, and slowing conduction of atrial fibrillation, growing evidence has cast doubt on their safety in patients with coronary disease. OBJECTIVE: To ... Full text Link to item Cite

Practice still makes perfect.

Journal Article Am Heart J · September 1999 Full text Link to item Cite

Cost-effectiveness of transesophageal echocardiography to determine the duration of therapy for intravascular catheter-associated Staphylococcus aureus bacteremia.

Journal Article Ann Intern Med · May 18, 1999 BACKGROUND: The appropriate duration of therapy for catheter-associated Staphylococcus aureus bacteremia is controversial. Conventional practice dictates that all patients receive prolonged courses of intravenous antibiotics. Some clinicians recommend abbr ... Full text Link to item Cite

The challenge of health care delivery to the elderly patient with cardiovascular disease. Demographic, epidemiologic, fiscal, and health policy implications.

Journal Article Cardiol Clin · February 1999 Old age as our society is experiencing it is a new phenomenon. Never before in history have societies of developed countries enjoyed such longevity of life. In the next several decades the United States will face an unparalleled increase in the absolute nu ... Full text Link to item Cite

Concealed mechanical bradycardia: an indication for permanent pacemaker implantation.

Journal Article Pacing Clin Electrophysiol · October 1998 We report a 51-year-old man with severe ischemic cardiomyopathy and heart failure in whom incessant bigeminal ventricular ectopy failed to generate a detectable arterial pressure. This created a mechanical bradycardia despite an adequate electrical heart r ... Full text Link to item Cite

The effects of New York's bypass surgery provider profiling on access to care and patient outcomes in the elderly.

Journal Article J Am Coll Cardiol · October 1998 OBJECTIVE: The aim of this study was to examine the effects of provider profiling on bypass surgery access and outcomes in elderly patients in New York. BACKGROUND: Since 1989, New York (NY) has compiled provider-specific bypass surgery mortality reports. ... Full text Link to item Cite

Treatment of hyperlipidemia by specialists versus generalists as secondary prevention of coronary artery disease.

Journal Article Am J Cardiol · November 15, 1997 Patients with known coronary disease and low-density lipoprotein >130 mg/dl who are followed by cardiologists after myocardial infarction are more than twice as likely to receive a cholesterol-lowering agent than patients followed by general internists. ... Full text Link to item Cite

Impact of early discharge after coronary artery bypass graft surgery on rates of hospital readmission and death. The Ischemic Heart Disease (IHD) Patient Outcomes Research Team (PORT) Investigators.

Journal Article J Am Coll Cardiol · October 1997 OBJECTIVES: This study examined the impact of early hospital discharge on short-term clinical outcomes of elderly patients treated with coronary artery bypass graft surgery (CABG) in the United States in 1992. BACKGROUND: Protocols that encourage earlier d ... Full text Link to item Cite

Relationship between physician and hospital coronary angioplasty volume and outcome in elderly patients.

Journal Article Circulation · June 3, 1997 BACKGROUND: With the expectation that physicians who perform larger numbers of coronary angioplasty procedures will have better outcomes, the American College of Cardiology/ American Heart Association guidelines recommend minimum physician volumes of 75 pr ... Full text Link to item Cite

Geographic variation in resource use for coronary artery bypass surgery. IHD Port Investigators.

Journal Article Med Care · April 1997 OBJECTIVES: The purpose of this study was to examine the national variability in patient-level cost and length of stay for coronary artery bypass grafting (CABG) in Medicare patients. METHODS: Retrospective multivariate regression analysis was done using M ... Full text Link to item Cite

Using Medicare claims data to assess provider quality for CABG surgery: does it work well enough?

Journal Article Health Serv Res · February 1997 OBJECTIVES: To assess the relative abilities of clinical and administrative data to predict mortality and to assess hospital quality of care for CABG surgery patients. DATA SOURCES/STUDY SETTING: 1991-1992 data from New York's Cardiac Surgery Reporting Sys ... Link to item Cite

Assessing the value of newer pharmacologic agents in non-ST elevation patients: a decision support system application.

Journal Article Proc AMIA Annu Fall Symp · 1997 Newer pharmacologic agents have demonstrated significant clinical and economic benefit in high-risk percutaneous transluminal coronary angioplasty (PTCA) patients. However, the higher costs of these agents may prohibit their use in lower-risk coronary arte ... Link to item Cite

Assessing the Value of Newer Pharmacologic Agents in Non-ST Elevation Patients: A Decision Support System Application

Journal Article Journal of the American Medical Informatics Association · January 1, 1997 Newer pharmacologic agents have demonstrated significant clinical and economic benefit in high-risk percutaneous transluminal coronary angioplasty (PTCA) patients. However, the higher costs of these agents may prohibit their use in lower-risk coronary arte ... Cite

Outcome of acute myocardial infarction according to the specialty of the admitting physician.

Journal Article N Engl J Med · December 19, 1996 BACKGROUND: In order to limit costs, health care organizations in the United States are shifting medical care from specialists to primary care physicians. Although primary care physicians provide less resource-intensive care, there is little information co ... Full text Link to item Cite

Left main stenosis.

Journal Article Ann Thorac Surg · October 1996 Full text Link to item Cite

Economic assessment of platelet glycoprotein IIb/IIIa inhibition for prevention of ischemic complications of high-risk coronary angioplasty. EPIC Investigators.

Journal Article Circulation · August 15, 1996 BACKGROUND: In the EPIC trial, c7E3 Fab, an antiplatelet IIb/ IIIa receptor antibody, reduced 30-day ischemic end points after high-risk coronary angioplasty by 35% and 6-month ischemic events by 23% but increased in-hospital bleeding episodes. METHODS AND ... Full text Link to item Cite

Impact of an interactive video on decision making of patients with ischemic heart disease.

Journal Article J Gen Intern Med · June 1996 An experimental pilot study using repeated measures to examine the impact of an interactive video program on the decision making of patients with ischemic heart disease was carried on at a tertiary care center and a Veterans Affairs hospital. The patients ... Full text Link to item Cite

A randomized study would answer the question.

Journal Article Ann Thorac Surg · February 1996 Full text Link to item Cite

Outcomes of coronary artery bypass graft surgery in 24,461 patients aged 80 years or older.

Journal Article Circulation · November 1, 1995 BACKGROUND: Coronary artery bypass graft surgery is increasingly common in patients of age > or = 80 years. Single-institution reviews have cited a wide range of mortality results after bypass surgery in this age group, in part because of limited sample si ... Full text Link to item Cite

The relation between the volume of coronary angioplasty procedures at hospitals treating Medicare beneficiaries and short-term mortality.

Journal Article N Engl J Med · December 15, 1994 BACKGROUND: Previous studies have found that hospitals at which more procedures, such as coronary-artery bypass grafting (CABG) and other vascular surgery, are performed have lower rates of mortality related to these procedures than hospitals where fewer s ... Full text Link to item Cite

Changes in mortality after myocardial revascularization in the elderly. The national Medicare experience.

Journal Article Ann Intern Med · December 15, 1994 OBJECTIVE: To examine secular changes in the use and outcome of percutaneous transluminal coronary angioplasty and cardiac bypass graft surgery in the elderly. DESIGN: A retrospective cohort study based on a longitudinal database created from the administr ... Full text Link to item Cite

Utility and limitations of claims data.

Journal Article Ann Intern Med · June 15, 1994 Full text Link to item Cite

Continuing evolution of therapy for coronary artery disease. Initial results from the era of coronary angioplasty.

Journal Article Circulation · May 1994 BACKGROUND: Survival after coronary artery bypass graft surgery (CABG) and medical therapy in patients with coronary artery disease (CAD) has been studied in both randomized trials and observational treatment comparisons. Over the past decade, the use of c ... Full text Link to item Cite

Intracranial hemorrhage risk and new thrombolytic therapies in acute myocardial infarction.

Journal Article Am J Cardiol · March 1, 1994 Thrombolytic therapy for acute myocardial infarction (AMI) has reduced mortality at the expense of additional intracranial hemorrhages. To determine whether this trade-off has been optimized, a decision analysis was performed using pooled data to determine ... Full text Link to item Cite

A comparison of administrative versus clinical data: coronary artery bypass surgery as an example. Ischemic Heart Disease Patient Outcomes Research Team.

Journal Article J Clin Epidemiol · March 1994 Health services researchers rely heavily on administrative data bases, but incomplete or incorrect coding may bias risk models based on administrative data. The best method for validating administrative data is to collect detailed information about the sam ... Full text Link to item Cite

Discordance of databases designed for claims payment versus clinical information systems. Implications for outcomes research.

Journal Article Ann Intern Med · October 15, 1993 OBJECTIVE: To determine the suitability of insurance claims information for use in clinical outcomes research in ischemic heart disease. DESIGN: Concordance study of two databases. SETTING: Tertiary care referral center. PATIENTS: A total of 12,937 consecu ... Full text Link to item Cite