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Changing patient characteristics and the effect on mortality in endocarditis.

Publication ,  Journal Article
Cabell, CH; Jollis, JG; Peterson, GE; Corey, GR; Anderson, DJ; Sexton, DJ; Woods, CW; Reller, LB; Ryan, T; Fowler, VG
Published in: Arch Intern Med
January 14, 2002

BACKGROUND: Limited data exist on recent demographic and microbiological changes in infective endocarditis (IE) and the impact of these changes on patient survival. METHODS: Data were collected from all patients with definite or possible IE at Duke University Medical Center, Durham, NC, from 1993 to 1999. Logistic regression analysis was used to identify demographic and microbiological changes that occurred in patients with IE over the study period. The impact of these changes on survival was evaluated using Cox proportional hazards modeling. RESULTS: Among the 329 study patients, rates of hemodialysis dependence, immunosuppression, and Staphylococcus aureus infection increased during the study period (P=.04, P=.008, and P<.001, respectively), while rates of infection due to viridans group streptococci decreased (P=.007). Hemodialysis was independently associated with S aureus infection (odds ratio, 3.1; 95% confidence interval, 1.6-5.9). Patients with S aureus IE had a higher 1-year mortality rate (43.9% vs 32.5%; P=.04) that persisted after adjustment for other illness severity characteristics (hazard ratio, 1.5; 95% confidence interval, 1.03-2.3). CONCLUSIONS: The demographic and microbiological characteristics of IE at our institution have changed over the past decade in ways that suggest a link between medical practice and IE characteristics. Staphylococcus aureus has emerged as a dominant cause of IE, and is an independent predictor of mortality. These findings identify clinical settings that may warrant closer surveillance and more aggressive measures in the identification and prevention of endocarditis.

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Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

January 14, 2002

Volume

162

Issue

1

Start / End Page

90 / 94

Location

United States

Related Subject Headings

  • Survival Rate
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Severity of Illness Index
  • Renal Dialysis
  • Proportional Hazards Models
  • Practice Patterns, Physicians'
  • Odds Ratio
  • Middle Aged
  • Male
 

Citation

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Cabell, C. H., Jollis, J. G., Peterson, G. E., Corey, G. R., Anderson, D. J., Sexton, D. J., … Fowler, V. G. (2002). Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med, 162(1), 90–94. https://doi.org/10.1001/archinte.162.1.90
Cabell, Christopher H., James G. Jollis, Gail E. Peterson, G Ralph Corey, Deverick J. Anderson, Daniel J. Sexton, Christopher W. Woods, L Barth Reller, Thomas Ryan, and Vance G. Fowler. “Changing patient characteristics and the effect on mortality in endocarditis.Arch Intern Med 162, no. 1 (January 14, 2002): 90–94. https://doi.org/10.1001/archinte.162.1.90.
Cabell CH, Jollis JG, Peterson GE, Corey GR, Anderson DJ, Sexton DJ, et al. Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med. 2002 Jan 14;162(1):90–4.
Cabell, Christopher H., et al. “Changing patient characteristics and the effect on mortality in endocarditis.Arch Intern Med, vol. 162, no. 1, Jan. 2002, pp. 90–94. Pubmed, doi:10.1001/archinte.162.1.90.
Cabell CH, Jollis JG, Peterson GE, Corey GR, Anderson DJ, Sexton DJ, Woods CW, Reller LB, Ryan T, Fowler VG. Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med. 2002 Jan 14;162(1):90–94.

Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

January 14, 2002

Volume

162

Issue

1

Start / End Page

90 / 94

Location

United States

Related Subject Headings

  • Survival Rate
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Severity of Illness Index
  • Renal Dialysis
  • Proportional Hazards Models
  • Practice Patterns, Physicians'
  • Odds Ratio
  • Middle Aged
  • Male