Scholars@Duke
Jason Koontz

Jason Koontz

Associate Professor of Medicine
Medicine, Cardiology
Box 3860 Med Ctr, Durham, NC 27710
Dept of Medicine, Durham, NC 27710

Selected Publications

Use of a Stylet Driven Lead With a Flexible Neck for Left Bundle Branch Area Pacing: A Single Center Experience.

Journal Article J Cardiovasc Electrophysiol · April 2025 BACKGROUND: The majority of data on left bundle branch area pacing (LBBAP) are on a lumenless lead. Data on the safety and effectiveness of stylet driven leads are comparatively lacking. METHODS: We retrospectively analyzed 265 patients who underwent attem ... Full text Link to item Cite

Appropriate and inappropriate ICD shocks in patients with LVADs: Prevalence, associated factors, and etiologies.

Journal Article Heart Rhythm · February 2025 BACKGROUND: Implantable cardioverter-defibrillator (ICD) shocks are a common complication after left ventricular assist device (LVAD) implantation; however, data on their frequency and causes are limited. OBJECTIVE: The purpose of this study was to define ... Full text Link to item Cite

Use of Ripple mapping to enhance localization and ablation of outflow tract premature ventricular contractions.

Journal Article J Cardiovasc Electrophysiol · July 2023 INTRODUCTION: Accurate localization of septal outflow tract premature ventricular contractions (PVCs) is often difficult due to frequent mid-myocardial or protected origin. Compared with traditional activation mapping, CARTO Ripple mapping provides visuali ... Full text Link to item Cite

Acute echocardiographic and hemodynamic response to his-bundle pacing in patients with first-degree atrioventricular block.

Journal Article Ann Noninvasive Electrocardiol · July 2022 BACKGROUND: Atrial pacing and right ventricular (RV) pacing are both associated with adverse outcomes among patients with first-degree atrioventricular block (1°AVB). His-bundle pacing (HBP) provides physiological activation of the ventricle and may be abl ... Full text Link to item Cite

Electrical storm in patients with left ventricular assist devices: Risk factors, incidence, and impact on survival.

Journal Article Heart Rhythm · August 2021 BACKGROUND: Ventricular arrhythmias (VAs) and electrical storm (ES) are recognized complications following left ventricular assist device (LVAD) implantation; however, their association with long term-outcomes remains poorly understood. OBJECTIVE: The purp ... Full text Link to item Cite

Stellate Ganglion Blockade: an Intervention for the Management of Ventricular Arrhythmias.

Journal Article Curr Hypertens Rep · October 23, 2020 PURPOSE OF REVIEW: To highlight the indications, procedural considerations, and data supporting the use of stellate ganglion blockade (SGB) for management of refractory ventricular arrhythmias. RECENT FINDINGS: In patients with refractory ventricular arrhy ... Full text Open Access Link to item Cite

Subcutaneous implantable cardioverter-defibrillator troubleshooting in patients with a left ventricular assist device: A case series and systematic review.

Journal Article Heart Rhythm · September 2020 BACKGROUND: There are limited data on the performance of the subcutaneous implantable cardioverter-defibrillator (S-ICD) in patients with a left ventricular assist device (LVAD). OBJECTIVE: The purpose of this study was to describe the clinical course and ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in patients with diabetes mellitus.

Journal Article Heart Rhythm O2 · August 2020 BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM. OBJECTIVE: The purpose of this study was to compa ... Full text Open Access Link to item Cite

Safety and efficacy outcomes of left atrial posterior wall isolation compared to pulmonary vein isolation and pulmonary vein isolation with linear ablation for the treatment of persistent atrial fibrillation.

Journal Article Am Heart J · February 2020 BACKGROUND: Pulmonary wall isolation (PWI) is increasingly used as an adjunctive lesion set to compliment pulmonary vein isolation (PVI), especially in patients with persistent atrial fibrillation (AF). The objective was to compare outcomes of catheter abl ... Full text Link to item Cite

Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology.

Journal Article J Arrhythm · February 2020 BACKGROUND: Catheter ablation is an important rhythm control therapy in patients with atrial fibrillation (AF) with concomitant heart failure (HF). The objective of this study was to assess the comparative efficacy of AF ablation patients with ischemic vs ... Full text Open Access Link to item Cite

Predicting atrial fibrillation recurrence after ablation in patients with heart failure: Validity of the APPLE and CAAP-AF risk scoring systems.

Journal Article Pacing Clin Electrophysiol · November 2019 BACKGROUND: Compared with medical therapy, catheter ablation of atrial fibrillation (AF) in patients with heart failure (HF) improves cardiovascular outcomes. Risk scores (CAAP-AF and APPLE) have been developed to predict the likelihood of AF recurrence af ... Full text Open Access Link to item Cite

Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction.

Journal Article Heart Rhythm · May 2018 BACKGROUND: Few studies have examined outcomes of catheter ablation for atrial fibrillation (AF) in patients with heart failure (HF) with preserved ejection fraction (HFpEF). OBJECTIVE: The purpose of this study was to compare outcomes of AF ablation in pa ... Full text Link to item Cite

Rethinking papillary muscle resection for refractory ventricular tachycardia in the LVAD era. A case report.

Journal Article J Electrocardiol · 2017 We report the case of a 57-year-old man with a history of ischemic cardiomyopathy who presented to the hospital with recurrent episodes of ventricular tachycardia refractory to antiarrhythmic medications. Mapping identified a deep premature ventricular con ... Full text Link to item Cite

COR-ART: A multicenter, randomized, double-blind, placebo-controlled dose-ranging study to evaluate single oral doses of vanoxerine for conversion of recent-onset atrial fibrillation or flutter to normal sinus rhythm.

Journal Article Heart Rhythm · June 2015 BACKGROUND: Restoration of sinus rhythm (SR) in patients with atrial fibrillation/atrial flutter (AF/AFL) is limited principally to direct current cardioversion. The multi-ion channel blocker vanoxerine may prove an effective alternative. OBJECTIVE: The pu ... Full text Link to item Cite

Contrast in intracardiac acoustic radiation force impulse images of radiofrequency ablation lesions.

Journal Article Ultrason Imaging · April 2014 We have previously shown that intracardiac acoustic radiation force impulse (ARFI) imaging visualizes tissue stiffness changes caused by radiofrequency ablation (RFA). The objectives of this in vivo study were to (1) quantify measured ARFI-induced displace ... Full text Open Access Link to item Cite

Impact of using a telescoping-support catheter system for left ventricular lead placement on implant success and procedure time of cardiac resynchronization therapy.

Journal Article Pacing Clin Electrophysiol · May 2013 BACKGROUND: Proper positioning of the left ventricular (LV) lead improves clinical outcomes and survival in patients receiving cardiac resynchronization therapy (CRT). Techniques of LV lead insertion using contrast injection and a telescoping system of del ... Full text Link to item Cite

Confirmation of cardiac radiofrequency ablation treatment using intra-procedure acoustic radiation force impulse imaging

Conference IEEE International Ultrasonics Symposium Ius · December 1, 2012 Recurrence of atrial fibrillation after transcatheter ablation (TCA) is common because there is no imaging modality that can visually confirm the presence of radiofrequency ablation (RFA) lesions. We have previously shown that acoustic radiation force impu ... Full text Cite

Intracardiac acoustic radiation force impulse imaging: a novel imaging method for intraprocedural evaluation of radiofrequency ablation lesions.

Journal Article Heart Rhythm · November 2012 BACKGROUND: Arrhythmia recurrence after cardiac radiofrequency ablation (RFA) for atrial fibrillation has been linked to conduction through discontinuous lesion lines. Intraprocedural visualization and corrective ablation of lesion line discontinuities cou ... Full text Open Access Link to item Cite

Predictors of mortality in patients with chronic kidney disease and an implantable defibrillator: an EPGEN substudy.

Journal Article Europace · December 2011 AIMS: Chronic kidney disease (CKD) is increasingly prevalent, and is an independent risk factor for cardiovascular mortality. Clinical trials of the implantable cardioverter-defibrillator (ICD) have demonstrated a survival benefit over medical therapy for ... Full text Link to item Cite

Use of ventricular synchronized triggered atrial pacing to facilitate hemodynamic support during mapping and catheter ablation of ventricular vachycardia.

Journal Article J Cardiovasc Electrophysiol · October 2011 Use of VSTAP to Facilitate Hemodynamic Support. The ablation of hemodynamically unstable ventricular tachycardia (VT) is challenging and frequently requires alternative mapping techniques or the use of percutaneous mechanical support devices. Loss of atrio ... Full text Link to item Cite

The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction.

Journal Article Circ Cardiovasc Genet · April 2011 BACKGROUND: Risk-stratifying heart failure patients for primary prevention implantable cardioverter-defibrillators (ICDs) remains a challenge, especially for blacks, who have an increased incidence of sudden cardiac death but have been underrepresented in ... Full text Link to item Cite

Retraction: A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N Engl J Med 2006;355:570-80.

Other N Engl J Med · March 24, 2011 To the Editor: We would like to retract our article, "A Genomic Strategy to Refine Prognosis in Early-Stage Non-Small-Cell Lung Cancer,"(1) which was published in the Journal on August 10, 2006. Using a sample set from a study by the American College of Su ... Full text Link to item Cite

Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository.

Journal Article Am Heart J · November 2009 BACKGROUND: Disturbances in cardiac rhythm can lead to significant morbidity and mortality. Many arrhythmias are known to have a heritable component, but the degree to which genetic variation contributes to disease risk and morbidity is poorly understood. ... Full text Link to item Cite

Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy.

Journal Article Med Dosim · 2009 Adjuvant radiotherapy for locally advanced prostate cancer improves biochemical and clinical disease-free survival. While comparisons in intact prostate cancer show a benefit for intensity modulated radiation therapy (IMRT) over 3D conformal planning, this ... Full text Link to item Cite

Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival.

Journal Article Proc Natl Acad Sci U S A · December 11, 2007 Polycomb group genes (PcGs) have been implicated in cancer based on altered levels of expression observed in certain tumors and the behavior of cultured cells containing inserted PcG transgenes. Endometrial stromal tumors provide evidence for a direct caus ... Full text Link to item Cite

Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms.

Journal Article Am J Surg Pathol · January 2007 Nonrandom cytogenetic abnormalities of chromosomes 6, 7, and 17 have been reported within low-grade endometrial stromal sarcomas (LGESSs), and among these abnormalities, the t(7;17)(p15;q21) is the most common aberration described. Previously we had shown ... Full text Link to item Cite

A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer.

Journal Article N Engl J Med · August 10, 2006 BACKGROUND: Clinical trials have indicated a benefit of adjuvant chemotherapy for patients with stage IB, II, or IIIA--but not stage IA--non-small-cell lung cancer (NSCLC). This classification scheme is probably an imprecise predictor of the prognosis of a ... Full text Link to item Cite

Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.

Journal Article Proc Natl Acad Sci U S A · May 22, 2001 Endometrial stromal tumors are divided into three types: benign stromal nodules, endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of cytogenetic abnormalities involving chromosome 7 have been reported in endometrial stroma ... Full text Link to item Cite

Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18.

Journal Article Cancer Res · December 15, 1999 Lymphomas arising in mucosa-associated lymphoid tissue (MALT) are indolent B-cell tumors that have a predilection for epithelial sites and often develop in a setting of chronic inflammation or autoimmunity. As many as 50% of low-grade MALT lymphomas contai ... Link to item Cite

Detection of mutations by cleavage of DNA heteroduplexes with bacteriophage resolvases.

Journal Article Nat Genet · February 1995 We have explored the application of the bacteriophage resolvases T4 endonuclease VII and T7 endonuclease I for detecting mutations in genomic DNA. Heteroduplex DNA fragments prepared by amplification from DNA containing known mutations were cleaved by one ... Full text Link to item Cite

Osmium-Promoted Dipolar Cycloadditions with Pyrroles: An Efficient, Stereoselective Synthesis of 7-Azanorbornanes

Journal Article Journal of the American Chemical Society · January 1, 1995 A series of 7-azabicyclo[2.2.1]hept-5-ene complexes are prepared from [Os(NH3)5(η2-L)]2+ (L = pyrrole, 1-methylpyrrole, 2,5-dimethylpyrrole, 1,2,5-trimethylpyrrole, or 1-(trimethylsilyl)pyrrole) and various dipol ... Full text Cite

β-Electrophilic Additions of Pentaammineosmium(II) β2-Pyrrole Complexes

Journal Article Journal of Organic Chemistry · January 1, 1995 The reactivity of a series of pyrrole complexes of the form [Os(NH3)5(4,5-2-L)]2+(OTf)2 (L = pyrrole and alkylated pyrroles) is surveyed with various electrophiles. The pyrrole ligand undergoes alkylat ... Full text Cite

η2-Pyrrole Complexes as Synthons to Alkaloid Derivatives

Journal Article Journal of Organic Chemistry · January 1, 1993 η2-Pyrrole complexes, readily generated from the corresponding pyrrole and Os(NH3)5(OTf)3, are combined with Michael acceptors under appropriate conditions to yield selectively α- or β-substituted 1H-pyrroles or ... Full text Cite

Tautomerizations, Protonations, and Electrophilic Additions of η2-Coordinated Pyrroles

Journal Article Journal of the American Chemical Society · July 1, 1992 A series of complexes is synthesized of the form [Os(NH3)5(2,3-η2-pyrrole)]2+, with pyrrole and various alkylated pyrroles. In contrast to the free ligands, these complexes can be protonated chemo- and stereosele ... Full text Cite