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Catheter ablation of atrial fibrillation in patients with diabetes mellitus.

Publication ,  Journal Article
Wang, A; Truong, T; Black-Maier, E; Green, C; Campbell, KB; Barnett, AS; Febre, J; Loring, Z; Al-Khatib, SM; Atwater, BD; Daubert, JP; Sun, AY ...
Published in: Heart rhythm O2
August 2020

Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM.The purpose of this study was to compare AF ablation outcomes in patients with and those without DM.We performed a retrospective analysis of 351 consecutive patients who underwent first-time AF ablation. Clinical outcomes included freedom from recurrent atrial arrhythmia, symptom burden (Mayo AF Symptom Inventory score), cardiovascular and all-cause hospitalizations, and periprocedural complications.Patients with DM (n = 65) were older, had a higher body mass index, more persistent AF, more hypertension, and larger left atrial diameter (P <.05 for all). Median (Q1, Q3) total radiofrequency duration [64.0 (43.6, 81.4) minutes vs 54.3 (39.2, 76.4) minutes; P = .132] and periprocedural complications (P = .868) did not differ between patients with and those without DM. After a median follow-up of 29.5 months, arrhythmia recurrence was significantly higher in the DM group compared to the no-DM group after adjustment for baseline differences (adjusted hazard ratio [HR] 2.24; 95% confidence [CI] 1.42-3.55; P = .001). There was a nonsignificant trend toward higher AF recurrence with worse glycemic levels (HR 1.29; 95% CI 0.99-1.69; P = .064).Although safety outcomes associated with AF ablation were similar between patients with and those without DM, arrhythmia-free survival was significantly lower among patients with DM. Poor glycemic control seems to an important risk factor for AF recurrence.

Duke Scholars

Published In

Heart rhythm O2

DOI

EISSN

2666-5018

ISSN

2666-5018

Publication Date

August 2020

Volume

1

Issue

3

Start / End Page

180 / 188
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, A., Truong, T., Black-Maier, E., Green, C., Campbell, K. B., Barnett, A. S., … Piccini, J. P. (2020). Catheter ablation of atrial fibrillation in patients with diabetes mellitus. Heart Rhythm O2, 1(3), 180–188. https://doi.org/10.1016/j.hroo.2020.04.006
Wang, Allen, Tracy Truong, Eric Black-Maier, Cynthia Green, Kristen B. Campbell, Adam S. Barnett, Janice Febre, et al. “Catheter ablation of atrial fibrillation in patients with diabetes mellitus.Heart Rhythm O2 1, no. 3 (August 2020): 180–88. https://doi.org/10.1016/j.hroo.2020.04.006.
Wang A, Truong T, Black-Maier E, Green C, Campbell KB, Barnett AS, et al. Catheter ablation of atrial fibrillation in patients with diabetes mellitus. Heart rhythm O2. 2020 Aug;1(3):180–8.
Wang, Allen, et al. “Catheter ablation of atrial fibrillation in patients with diabetes mellitus.Heart Rhythm O2, vol. 1, no. 3, Aug. 2020, pp. 180–88. Epmc, doi:10.1016/j.hroo.2020.04.006.
Wang A, Truong T, Black-Maier E, Green C, Campbell KB, Barnett AS, Febre J, Loring Z, Al-Khatib SM, Atwater BD, Daubert JP, Frazier-Mills C, Hegland DD, Jackson KP, Jackson LR, Koontz JI, Lewis RK, Pokorney SD, Sun AY, Thomas KL, Bahnson TD, Piccini JP. Catheter ablation of atrial fibrillation in patients with diabetes mellitus. Heart rhythm O2. 2020 Aug;1(3):180–188.

Published In

Heart rhythm O2

DOI

EISSN

2666-5018

ISSN

2666-5018

Publication Date

August 2020

Volume

1

Issue

3

Start / End Page

180 / 188