Scholars@Duke
Jay Alan Baker

Jay Alan Baker

Professor of Radiology
Radiology, Breast Imaging
jay.baker@duke.edu
Box 3808 Med Ctr, Durham, NC
Dept of Radiology, Durham, NC
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Selected Publications

Impact of Interruptions During Screening Mammography on Physician Well-Being and Patient Care.

Journal Article J Am Coll Radiol · June 2024 OBJECTIVE: To assess the impact of interruptions on radiologists' efficiency, accuracy, and job satisfaction in interpreting screening mammograms. METHODS: This institutional review board-approved retrospective reader study recruited nine breast radiologis ... Full text Link to item Cite

Patient Preferences of Breast Radiologists' Attire and Appearance.

Journal Article Acad Radiol · April 2024 RATIONALE AND OBJECTIVES: To assess patient preferences for breast radiologists' attire and appearance. MATERIALS AND METHODS: A multi-institutional anonymous, voluntary 19-question survey was administered to patients undergoing screening and diagnostic ma ... Full text Link to item Cite

Now or Later? Patient Satisfaction and Anxiety Among Women Undergoing Breast Biopsies Performed the Same Day as Recommended Versus a Later Day.

Journal Article J Am Coll Radiol · March 2024 PURPOSE: The aim of this study was to determine differences in patient satisfaction and anxiety among women undergoing core-needle breast biopsies performed the same day as recommended versus a future date. METHODS: After institutional review board exempti ... Full text Link to item Cite

Breast Cancer Risk Assessment and Screening Practices Reported Via an Online Survey.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Breast cancer screening guidelines differ between organizations, and significant variations in practice patterns exist. Previous evidence suggests that provider-level factors are the greatest contributors to risk assessment and screening practi ... Full text Link to item Cite

Ethanol Sclerotherapy for Postoperative Seroma of the Breast and Axilla.

Journal Article J Breast Imaging · March 20, 2023 OBJECTIVE: Evaluate the effectiveness of alcohol sclerotherapy in postoperative breast and axillary seromas. METHODS: This was an IRB-approved retrospective review of consecutive patients from 2017 to 2021. The procedure involves aspiration of seroma fluid ... Full text Link to item Cite

Contrast-Enhanced In-Phase Dixon Sequence: Impact on Biopsy Clip Detection on Breast MRI.

Journal Article AJR Am J Roentgenol · March 2023 BACKGROUND. Identification of breast biopsy clips using conventional MRI sequences may be challenging. A contrast-enhanced in-phase Dixon sequence may have greater conspicuity for areas of susceptibility compared with standard clinical sequences. OBJECTIVE ... Full text Link to item Cite

Benefits and Risks of Mammography Screening in Women Ages 40 to 49 Years.

Journal Article J Prim Care Community Health · 2022 Breast cancer screening in the United States is complicated by conflicting recommendations from professional and governmental organizations. The benefits and risks of breast cancer screening differ though by age which should influence shared decision-makin ... Full text Link to item Cite

Location, Location, Location.

Journal Article J Breast Imaging · August 12, 2021 Full text Link to item Cite

Mixed-Methods Study to Predict Upstaging of DCIS to Invasive Disease on Mammography.

Journal Article AJR Am J Roentgenol · April 2021 BACKGROUND. The incidence of ductal carcinoma in situ (DCIS) has steadily increased, as have concerns regarding overtreatment. Active surveillance is a novel treatment strategy that avoids surgical excision, but identifying patients with occult invasive di ... Full text Link to item Cite

Predicting Upstaging of DCIS to Invasive Disease: Radiologists's Predictive Performance.

Journal Article Acad Radiol · November 2020 RATIONALE AND OBJECTIVES: The purpose of this study is to quantify breast radiologists' performance at predicting occult invasive disease when ductal carcinoma in situ (DCIS) presents as calcifications on mammography and to identify imaging and histopathol ... Full text Link to item Cite

Impact of Colorized Display of Mammograms on Lesion Detection.

Journal Article J Breast Imaging · February 4, 2020 OBJECTIVE: To assess the effect of the colorized display of digital mammograms on observer detection of subtle breast lesions. METHODS: Three separate observer studies compared detection performance using grayscale versus color display of 1) low-contrast m ... Full text Link to item Cite

Can Digital Breast Tomosynthesis Replace Full-Field Digital Mammography? A Multireader, Multicase Study of Wide-Angle Tomosynthesis.

Journal Article AJR Am J Roentgenol · June 2019 OBJECTIVE. The purpose of this study was to test the hypothesis whether two-view wide-angle digital breast tomosynthesis (DBT) can replace full-field digital mammography (FFDM) for breast cancer detection. SUBJECTS AND METHODS. In a multireader multicase s ... Full text Link to item Cite

Breast cancer deaths averted over 3 decades.

Journal Article Cancer · May 1, 2019 BACKGROUND: From 1975 to 1990, female breast cancer mortality rates in the United States increased by 0.4% per year. Since 1990, breast cancer mortality rates have fallen between 1.8% and 3.4% per year, a decrease that is attributed to increased mammograph ... Full text Link to item Cite

MRI predictors of tumor-positive margins after breast-conserving surgery.

Journal Article Clin Imaging · 2019 PURPOSE: The purpose of this study is to identify predictors of tumor-positive surgical margins after breast-conserving surgery on dynamic contrast-enhanced (DCE) MRI. MATERIALS AND METHODS: We conducted a retrospective study of consecutive women who under ... Full text Link to item Cite

Findings on Surveillance Imaging After Preoperative Partial Breast Irradiation for Early Stage Breast Cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: To evaluate the mammographic sequelae of preoperative accelerated partial breast irradiation (APBI) delivered via either stereotactic radiosurgery or a conventionally fractionated regimen. METHODS AND MATERIALS: This multicenter, retrospective stu ... Full text Link to item Cite

Prediction of Occult Invasive Disease in Ductal Carcinoma in Situ Using Deep Learning Features.

Journal Article J Am Coll Radiol · March 2018 PURPOSE: The aim of this study was to determine whether deep features extracted from digital mammograms using a pretrained deep convolutional neural network are prognostic of occult invasive disease for patients with ductal carcinoma in situ (DCIS) on core ... Full text Link to item Cite

False Information About Breast Cancer Screening.

Journal Article JAMA Intern Med · February 1, 2018 Full text Link to item Cite

Relationships Between MRI Breast Imaging-Reporting and Data System (BI-RADS) Lexicon Descriptors and Breast Cancer Molecular Subtypes: Internal Enhancement is Associated with Luminal B Subtype.

Journal Article Breast J · September 2017 The aim of this study was to determine the associations between breast MRI findings using the Breast Imaging-Reporting and Data System (BI-RADS) lexicon descriptors and breast cancer molecular subtypes. In this retrospective, IRB-approved, single instituti ... Full text Link to item Cite

Impact of Interruptions During Screening Mammography on Physician Well-Being and Patient Care.

Journal Article J Am Coll Radiol · June 2024 OBJECTIVE: To assess the impact of interruptions on radiologists' efficiency, accuracy, and job satisfaction in interpreting screening mammograms. METHODS: This institutional review board-approved retrospective reader study recruited nine breast radiologis ... Full text Link to item Cite

Patient Preferences of Breast Radiologists' Attire and Appearance.

Journal Article Acad Radiol · April 2024 RATIONALE AND OBJECTIVES: To assess patient preferences for breast radiologists' attire and appearance. MATERIALS AND METHODS: A multi-institutional anonymous, voluntary 19-question survey was administered to patients undergoing screening and diagnostic ma ... Full text Link to item Cite

Now or Later? Patient Satisfaction and Anxiety Among Women Undergoing Breast Biopsies Performed the Same Day as Recommended Versus a Later Day.

Journal Article J Am Coll Radiol · March 2024 PURPOSE: The aim of this study was to determine differences in patient satisfaction and anxiety among women undergoing core-needle breast biopsies performed the same day as recommended versus a future date. METHODS: After institutional review board exempti ... Full text Link to item Cite

Breast Cancer Risk Assessment and Screening Practices Reported Via an Online Survey.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Breast cancer screening guidelines differ between organizations, and significant variations in practice patterns exist. Previous evidence suggests that provider-level factors are the greatest contributors to risk assessment and screening practi ... Full text Link to item Cite

Ethanol Sclerotherapy for Postoperative Seroma of the Breast and Axilla.

Journal Article J Breast Imaging · March 20, 2023 OBJECTIVE: Evaluate the effectiveness of alcohol sclerotherapy in postoperative breast and axillary seromas. METHODS: This was an IRB-approved retrospective review of consecutive patients from 2017 to 2021. The procedure involves aspiration of seroma fluid ... Full text Link to item Cite

Contrast-Enhanced In-Phase Dixon Sequence: Impact on Biopsy Clip Detection on Breast MRI.

Journal Article AJR Am J Roentgenol · March 2023 BACKGROUND. Identification of breast biopsy clips using conventional MRI sequences may be challenging. A contrast-enhanced in-phase Dixon sequence may have greater conspicuity for areas of susceptibility compared with standard clinical sequences. OBJECTIVE ... Full text Link to item Cite

Benefits and Risks of Mammography Screening in Women Ages 40 to 49 Years.

Journal Article J Prim Care Community Health · 2022 Breast cancer screening in the United States is complicated by conflicting recommendations from professional and governmental organizations. The benefits and risks of breast cancer screening differ though by age which should influence shared decision-makin ... Full text Link to item Cite

Location, Location, Location.

Journal Article J Breast Imaging · August 12, 2021 Full text Link to item Cite

Mixed-Methods Study to Predict Upstaging of DCIS to Invasive Disease on Mammography.

Journal Article AJR Am J Roentgenol · April 2021 BACKGROUND. The incidence of ductal carcinoma in situ (DCIS) has steadily increased, as have concerns regarding overtreatment. Active surveillance is a novel treatment strategy that avoids surgical excision, but identifying patients with occult invasive di ... Full text Link to item Cite

Predicting Upstaging of DCIS to Invasive Disease: Radiologists's Predictive Performance.

Journal Article Acad Radiol · November 2020 RATIONALE AND OBJECTIVES: The purpose of this study is to quantify breast radiologists' performance at predicting occult invasive disease when ductal carcinoma in situ (DCIS) presents as calcifications on mammography and to identify imaging and histopathol ... Full text Link to item Cite

Impact of Colorized Display of Mammograms on Lesion Detection.

Journal Article J Breast Imaging · February 4, 2020 OBJECTIVE: To assess the effect of the colorized display of digital mammograms on observer detection of subtle breast lesions. METHODS: Three separate observer studies compared detection performance using grayscale versus color display of 1) low-contrast m ... Full text Link to item Cite

Can Digital Breast Tomosynthesis Replace Full-Field Digital Mammography? A Multireader, Multicase Study of Wide-Angle Tomosynthesis.

Journal Article AJR Am J Roentgenol · June 2019 OBJECTIVE. The purpose of this study was to test the hypothesis whether two-view wide-angle digital breast tomosynthesis (DBT) can replace full-field digital mammography (FFDM) for breast cancer detection. SUBJECTS AND METHODS. In a multireader multicase s ... Full text Link to item Cite

Breast cancer deaths averted over 3 decades.

Journal Article Cancer · May 1, 2019 BACKGROUND: From 1975 to 1990, female breast cancer mortality rates in the United States increased by 0.4% per year. Since 1990, breast cancer mortality rates have fallen between 1.8% and 3.4% per year, a decrease that is attributed to increased mammograph ... Full text Link to item Cite

MRI predictors of tumor-positive margins after breast-conserving surgery.

Journal Article Clin Imaging · 2019 PURPOSE: The purpose of this study is to identify predictors of tumor-positive surgical margins after breast-conserving surgery on dynamic contrast-enhanced (DCE) MRI. MATERIALS AND METHODS: We conducted a retrospective study of consecutive women who under ... Full text Link to item Cite

Findings on Surveillance Imaging After Preoperative Partial Breast Irradiation for Early Stage Breast Cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: To evaluate the mammographic sequelae of preoperative accelerated partial breast irradiation (APBI) delivered via either stereotactic radiosurgery or a conventionally fractionated regimen. METHODS AND MATERIALS: This multicenter, retrospective stu ... Full text Link to item Cite

Prediction of Occult Invasive Disease in Ductal Carcinoma in Situ Using Deep Learning Features.

Journal Article J Am Coll Radiol · March 2018 PURPOSE: The aim of this study was to determine whether deep features extracted from digital mammograms using a pretrained deep convolutional neural network are prognostic of occult invasive disease for patients with ductal carcinoma in situ (DCIS) on core ... Full text Link to item Cite

False Information About Breast Cancer Screening.

Journal Article JAMA Intern Med · February 1, 2018 Full text Link to item Cite

Relationships Between MRI Breast Imaging-Reporting and Data System (BI-RADS) Lexicon Descriptors and Breast Cancer Molecular Subtypes: Internal Enhancement is Associated with Luminal B Subtype.

Journal Article Breast J · September 2017 The aim of this study was to determine the associations between breast MRI findings using the Breast Imaging-Reporting and Data System (BI-RADS) lexicon descriptors and breast cancer molecular subtypes. In this retrospective, IRB-approved, single instituti ... Full text Link to item Cite

Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features?

Journal Article Acad Radiol · September 2017 RATIONALE AND OBJECTIVES: This study aimed to determine whether mammographic features assessed by radiologists and using computer algorithms are prognostic of occult invasive disease for patients showing ductal carcinoma in situ (DCIS) only in core biopsy. ... Full text Link to item Cite

Impact of Sodium Bicarbonate-Buffered Lidocaine on Patient Pain During Image-Guided Breast Biopsy.

Journal Article J Am Coll Radiol · September 2017 PURPOSE: This randomized, double-blind controlled study evaluated the effectiveness of sodium bicarbonate-buffered lidocaine on reducing pain during imaging-guided breast biopsies. MATERIALS AND METHODS: This prospective, HIPAA-compliant study randomly ass ... Full text Link to item Cite

Suspicious breast calcifications undergoing stereotactic biopsy in women ages 70 and over: Breast cancer incidence by BI-RADS descriptors.

Journal Article Eur Radiol · June 2017 OBJECTIVES: To determine the malignancy rate overall and for specific BI-RADS descriptors in women ≥70 years who undergo stereotactic biopsy for calcifications. METHODS: We retrospectively reviewed 14,577 consecutive mammogram reports in 6839 women ≥70 yea ... Full text Link to item Cite

Anxiety prior to breast biopsy: Relationships with length of time from breast biopsy recommendation to biopsy procedure and psychosocial factors.

Journal Article J Health Psychol · April 2017 This study investigated how time from breast biopsy recommendation to biopsy procedure affected pre-biopsy anxiety ( N = 140 women), and whether the relationship between wait time and anxiety was affected by psychosocial factors (chronic life stress, traum ... Full text Link to item Cite

Patient Anxiety Before and Immediately After Imaging-Guided Breast Biopsy Procedures: Impact of Radiologist-Patient Communication.

Journal Article J Am Coll Radiol · November 2016 PURPOSE: The aim of this study was to evaluate patient anxiety and its association with perceived radiologist-patient communication in the setting of imaging-guided breast biopsy. METHODS: After informed consent was obtained, 138 women recommended for imag ... Full text Link to item Cite

Impact of Breast Density Notification Legislation on Radiologists' Practices of Reporting Breast Density: A Multi-State Study.

Journal Article Radiology · September 2016 Purpose To evaluate the impact of breast density notification legislation on breast density reporting by radiologists nationally. Materials and Methods The institutional review board exempted this HIPAA-compliant retrospective study from the requirement fo ... Full text Link to item Cite

How does c-view image quality compare with conventional 2D FFDM?

Journal Article Med Phys · May 2016 PURPOSE: The FDA approved the use of digital breast tomosynthesis (DBT) in 2011 as an adjunct to 2D full field digital mammography (FFDM) with the constraint that all DBT acquisitions must be paired with a 2D image to assure adequate interpretative informa ... Full text Link to item Cite

In Estimating Overdiagnosis, Details Matter.

Journal Article Acad Radiol · January 2016 Full text Link to item Cite

Evaluation of Pathologic Nipple Discharge: What is the Added Diagnostic Value of MRI?

Journal Article Ann Surg Oncol · December 2015 PURPOSE: To determine the diagnostic value of magnetic resonance imaging (MRI) for the evaluation of patients with pathologic nipple discharge. METHODS: We performed a retrospective review of women with nipple discharge who underwent breast MRI between Jan ... Full text Link to item Cite

Architectural Distortion on Mammography: Correlation With Pathologic Outcomes and Predictors of Malignancy.

Journal Article AJR Am J Roentgenol · December 2015 OBJECTIVE: The objective of our study was to determine the risk of malignancy associated with architectural distortion and to evaluate the imaging and clinical features that may contribute to the prediction of malignancy in the setting of architectural dis ... Full text Link to item Cite

Preoperative Partial Breast Radiation Therapy: Short-term Imaging Outcomes With Two Unique Treatment Regimens

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

Frequency of Malignancy and Imaging Characteristics of Probably Benign Lesions Seen at Breast MRI.

Journal Article AJR Am J Roentgenol · August 2015 OBJECTIVE: The purposes of this study were to evaluate the frequency, follow-up compliance, and cancer rate of MRI BI-RADS category 3 lesions and to determine the cancer rate for individual BI-RADS descriptors. MATERIALS AND METHODS: A retrospective review ... Full text Link to item Cite

Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2015 PURPOSE: Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for ... Full text Link to item Cite

Diagnostic Value of Ultrasound in Female Patients With Nipple Discharge.

Journal Article AJR Am J Roentgenol · July 2015 OBJECTIVE: The purpose of this study was to assess the contribution of ultrasound to the evaluation of patients with pathologic nipple discharge. MATERIALS AND METHODS: A retrospective review was conducted of the records of females who presented with nippl ... Full text Link to item Cite

Interobserver Variability Between Breast Imagers Using the Fifth Edition of the BI-RADS MRI Lexicon.

Journal Article AJR Am J Roentgenol · May 2015 OBJECTIVE: The purpose of this study was to assess the interobserver variability of users of the MRI lexicon in the fifth edition of the BI-RADS atlas. MATERIALS AND METHODS: Three breast imaging specialists reviewed 280 routine clinical breast MRI finding ... Full text Link to item Cite

Can breast cancer molecular subtype help to select patients for preoperative MR imaging?

Journal Article Radiology · February 2015 PURPOSE: To assess whether breast cancer molecular subtype classified by surrogate markers can be used to predict the extent of clinically relevant disease with preoperative breast magnetic resonance (MR) imaging. MATERIALS AND METHODS: In this HIPAA-compl ... Full text Link to item Cite

A phase 1 trial of preoperative partial breast radiation therapy: Patient selection, target delineation, and dose delivery.

Journal Article Pract Radiat Oncol · 2015 PURPOSE: Diffusion of accelerated partial breast irradiation into clinical practice is limited by the need for specialized equipment and training. The accessible external beam technique yields unacceptable complication rates, likely from large postoperativ ... Full text Link to item Cite

Abstract P5-14-04: Preoperative single-fraction partial breast radiotherapy – Initial results from a novel phase I dose-escalation protocol with exploration of radiation response biomarkers

Conference Cancer Research · December 15, 2013 AbstractPurpose/Objectives(s): Women with biologically favorable early stage breast cancer are increasingly treated with accelerated partial breast techniques. However, many alternative techniques require co ... Full text Cite

Patient anxiety before and immediately after imaging-guided breast biopsy procedures: impact of radiologist-patient communication.

Journal Article J Am Coll Radiol · June 2013 PURPOSE: The aim of this study was to evaluate patient anxiety and its association with perceived radiologist-patient communication in the setting of imaging-guided breast biopsy. METHODS: After informed consent was obtained, 138 women recommended for imag ... Full text Link to item Cite

Cancelation of MRI guided breast biopsies for suspicious breast lesions identified at 3.0 T MRI: reasons, rates, and outcomes.

Journal Article Acad Radiol · May 2013 RATIONALE AND OBJECTIVES: To determine the cancelation rate of magnetic resonance imaging (MRI)-guided procedures in suspicious breast lesions initially detected at 3.0 Tesla (T) MRI. MATERIALS AND METHODS: With institutional review board approval, a Healt ... Full text Link to item Cite

Multidisciplinary care of patients with early-stage breast cancer.

Journal Article Surg Oncol Clin N Am · April 2013 There is a compelling need for close coordination and integration of multiple specialties in the management of patients with early-stage breast cancer. Optimal patient care and outcomes depend on the sequential and often simultaneous participation and dial ... Full text Link to item Cite

Identifying error-making patterns in assessment of mammographic BI-RADS descriptors among radiology residents using statistical pattern recognition.

Journal Article Acad Radiol · July 2012 RATIONALE AND OBJECTIVE: The objective of this study is to test the hypothesis that there are patterns in erroneous assessment of BI-RADS features among radiology trainees when interpreting mammographic masses and that these patterns can be captured in ind ... Full text Link to item Cite

Suspicious breast lesions detected at 3.0 T magnetic resonance imaging: clinical and histological outcomes.

Journal Article Acad Radiol · June 2012 RATIONALE AND OBJECTIVES: To evaluate the imaging features and histological and clinical outcomes of a series of suspicious, mammographically occult breast lesions detected at 3.0 T magnetic resonance imaging (MRI). MATERIALS AND METHODS: Approval was obta ... Full text Link to item Cite

Using the BI-RADS lexicon in a restrictive form of double reading as a strategy for minimizing screening mammography recall rates.

Journal Article AJR Am J Roentgenol · April 2012 OBJECTIVE: The purpose of this article is to determine the potential reduction in screening recall rates by strictly following standardized BI-RADS lexicon for lesions seen on screening mammography. MATERIALS AND METHODS: Of 3084 consecutive mammograms per ... Full text Link to item Cite

Imaging-guided preoperative hookwire localization of nonpalpable extramammary lesions.

Journal Article AJR Am J Roentgenol · September 2011 OBJECTIVE: Imaging-guided hookwire localization of nonpalpable lesions in the breast is frequently performed preoperatively. Outside the breast, this procedure is useful for planning resection of lesions in anatomic regions without intrinsic landmarks. The ... Full text Link to item Cite

Titanium vs carbon coated ceramic breast tissue marker clips: 3T MR susceptibility artifact and local signal disturbance.

Journal Article Acad Radiol · June 2011 RATIONALE AND OBJECTIVES: Spectroscopy signal of a breast lesion may be disrupted by the presence of metal from a biopsy marking clip. This study compares the size of magnetic resonance (MR) susceptibility artifacts and degree of local spectroscopy signal ... Full text Link to item Cite

Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection.

Journal Article Med Phys · April 2011 PURPOSE: Mammography is known to be one of the most difficult radiographic exams to interpret. Mammography has important limitations, including the superposition of normal tissue that can obscure a mass, chance alignment of normal tissue to mimic a true le ... Full text Link to item Cite

Computer-aided classification of breast masses: performance and interobserver variability of expert radiologists versus residents.

Journal Article Radiology · January 2011 PURPOSE: To evaluate the interobserver variability in descriptions of breast masses by dedicated breast imagers and radiology residents and determine how any differences in lesion description affect the performance of a computer-aided diagnosis (CAD) compu ... Full text Link to item Cite

Clinical prototype of autonomous breast biopsy robot guided by 4Dultrasound

Journal Article Proceedings - IEEE Ultrasonics Symposium · December 1, 2010 Our laboratory previously conducted feasibility studies of autonomousrobotic breast biopsy guided by 4D ultrasound. Using a complete 3D image volume,processed by elementary thresholding algorithms with no human intervention, therobot was able to successful ... Full text Cite

Is surgical excision of core biopsy proven benign papillomas of the breast necessary?

Journal Article Acad Radiol · May 2010 RATIONALE AND OBJECTIVES: The aim of this study was to determine if core biopsy-proven benign papillomas of the breast need to be surgically excised. MATERIALS AND METHODS: Mammographic and pathologic database review from January 1994 to January 2004 revea ... Full text Link to item Cite

Individualized computer-aided education in mammography based on user modeling: concept and preliminary experiments.

Journal Article Med Phys · March 2010 PURPOSE: The authors propose the framework for an individualized adaptive computer-aided educational system in mammography that is based on user modeling. The underlying hypothesis is that user models can be developed to capture the individual error making ... Full text Link to item Cite

Novel tumor sampling strategies to enable microarray gene expression signatures in breast cancer: a study to determine feasibility and reproducibility in the context of clinical care.

Journal Article Breast Cancer Res Treat · December 2009 Featured Publication Feasibility and reproducibility of microarray biomarkers in clinical settings are doubted because of reliance on fresh frozen tissue. We sought to develop and validate a paradigm of frozen tissue collection from early breast tumors to enable use of microar ... Full text Link to item Cite

Optimized image acquisition for breast tomosynthesis in projection and reconstruction space.

Journal Article Med Phys · November 2009 Breast tomosynthesis has been an exciting new development in the field of breast imaging. While the diagnostic improvement via tomosynthesis is notable, the full potential of tomosynthesis has not yet been realized. This may be attributed to the dependency ... Full text Link to item Cite

Breast self-examination: defining a cohort still in need.

Journal Article Am J Surg · October 2009 BACKGROUND: The value of breast self-examination (BSE) to detect early breast cancer is controversial. METHODS: Within an institutional review board-approved prospective study, 147 high-risk women were enrolled from 2004 to 2007. Yearly clinical examinatio ... Full text Link to item Cite

Can compression be reduced for breast tomosynthesis? Monte carlo study on mass and microcalcification conspicuity in tomosynthesis.

Journal Article Radiology · June 2009 Featured Publication PURPOSE: To assess, in a voxelized anthropomorphic breast phantom, how the conspicuity of breast masses and microcalcifications may be affected by applying reduced breast compression in tomosynthesis. MATERIALS AND METHODS: A breast tomosynthesis system wa ... Full text Link to item Cite

The influence of increased ambient lighting on mass detection in mammograms.

Journal Article Acad Radiol · March 2009 RATIONALE AND OBJECTIVES: Recent research has provided evidence that in reading rooms equipped with liquid crystal displays (LCDs), a measured increase of ambient lighting may improve clinicians' detection performance. In agreement with this research, the ... Full text Link to item Cite

Automated breast mass detection in 3D reconstructed tomosynthesis volumes: a featureless approach.

Journal Article Med Phys · August 2008 Featured Publication The purpose of this study was to propose and implement a computer aided detection (CADe) tool for breast tomosynthesis. This task was accomplished in two stages-a highly sensitive mass detector followed by a false positive (FP) reduction stage. Breast tomo ... Full text Link to item Cite

A mathematical model platform for optimizing a multiprojection breast imaging system.

Journal Article Med Phys · April 2008 Featured Publication Multiprojection imaging is a technique in which a plurality of digital radiographic images of the same patient are acquired within a short interval of time from slightly different angles. Information from each image is combined to determine the final diagn ... Full text Link to item Cite

Training neural network classifiers for medical decision making: the effects of imbalanced datasets on classification performance.

Journal Article Neural Netw · 2008 Featured Publication This study investigates the effect of class imbalance in training data when developing neural network classifiers for computer-aided medical diagnosis. The investigation is performed in the presence of other characteristics that are typical among medical d ... Full text Link to item Cite

Does image quality matter? Impact of resolution and noise on mammographic task performance.

Journal Article Med Phys · October 2007 The purpose of this study was to examine the effects of different resolution and noise levels on task performance in digital mammography. This study created an image set with images at three different resolution levels, corresponding to three digital displ ... Full text Link to item Cite

Breast mass lesions: computer-aided diagnosis models with mammographic and sonographic descriptors.

Journal Article Radiology · August 2007 Featured Publication PURPOSE: To retrospectively develop and evaluate computer-aided diagnosis (CAD) models that include both mammographic and sonographic descriptors. MATERIALS AND METHODS: Institutional review board approval was obtained for this HIPAA-compliant study. A wai ... Full text Link to item Cite

Digital mammography: effects of reduced radiation dose on diagnostic performance.

Journal Article Radiology · May 2007 Featured Publication PURPOSE: To experimentally determine the relationship between radiation dose and observer accuracy in the detection and discrimination of simulated lesions for digital mammography. MATERIALS AND METHODS: This HIPAA-compliant study received institutional re ... Full text Link to item Cite

Minimal Screening Mammography Recall Rates Using Standardized BI-RADS Criteria

Journal Article AMERICAN JOURNAL OF ROENTGENOLOGY · May 1, 2007 Link to item Cite

Comparison of LCD and CRT displays based on efficacy for digital mammography.

Journal Article Acad Radiol · November 2006 RATIONALE AND OBJECTIVES: To compare two display technologies, cathode ray tube (CRT) and liquid crystal display (LCD), in terms of diagnostic accuracy for several common clinical tasks in digital mammography. MATERIALS AND METHODS: Simulated masses and mi ... Full text Link to item Cite

Optimized approach to decision fusion of heterogeneous data for breast cancer diagnosis.

Journal Article Med Phys · August 2006 Featured Publication As more diagnostic testing options become available to physicians, it becomes more difficult to combine various types of medical information together in order to optimize the overall diagnosis. To improve diagnostic performance, here we introduce an approa ... Full text Link to item Cite

Simulation of mammographic lesions.

Journal Article Acad Radiol · July 2006 RATIONALE AND OBJECTIVES: This study presents a method for generating breast masses and microcalcifications in mammography via simulation. This simulation method allows for the creation of large image datasets with particular lesions, which may serve as a ... Full text Link to item Cite

Gaussian frequency blending algorithm with Matrix Inversion Tomosynthesis (MITS) and Filtered Back Projection (FBP) for better digital breast tomosynthesis reconstruction

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 30, 2006 Breast cancer is a major problem and the most common cancer among women. The nature of conventional mammography makes it very difficult to distinguish a cancer from overlying breast tissues. Digital Tomosynthesis refers to a three-dimensional imaging techn ... Full text Cite

The effect of data set size on computer-aided diagnosis of breast cancer: Comparing decision fusion to a linear discriminant

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 23, 2006 Data sets with relatively few observations (cases) in medical research are common, especially if the data are expensive or difficult to collect. Such small sample sizes usually do not provide enough information for computer models to learn data patterns we ... Full text Cite

MRI-guided vacuum-assisted breast biopsy with a handheld portable biopsy system.

Journal Article AJR Am J Roentgenol · June 2006 Featured Publication OBJECTIVE: The purpose of this study was to evaluate a compact portable 10-gauge handheld battery-operated vacuum-assisted biopsy system for MRI-guided breast biopsy. CONCLUSION: The compact portable battery-operated biopsy system can be used successfully ... Full text Link to item Cite

Streaming detection for evaluation of indeterminate sonographic breast masses: a pilot study.

Journal Article AJR Am J Roentgenol · May 2006 Featured Publication OBJECTIVE: Streaming detection is a novel sonography technique that uses ultrasonic energy to induce movement in cyst fluid that is detected on Doppler sonography. This pilot study evaluates the utility of streaming detection for differentiating cysts from ... Full text Link to item Cite

Reply [2]

Journal Article American Journal of Roentgenology · March 1, 2006 Full text Cite

SU‐FF‐I‐21: Two‐Dimensional Shift‐And‐Add (SAA) Algorithm for Digital Breast Tomosynthesis Reconstruction

Conference Medical Physics · January 1, 2006 Purpose: To investigate a two‐dimensional Shift‐And‐Add algorithm for three‐dimensional digital breast tomosynthsis reconstruction to correct for defects existing in the traditional Shift‐And‐Add algorithm that calculates only one‐dimensional shift amount ... Full text Cite

Effect of display resolution on the detection of mammographie lesions

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · September 19, 2005 For diagnosis of breast cancer by mammography, the mammograms must be viewed by a radiologist. The purpose of this study was to determine the effect of display resolution on the specific clinical task of detection of breast lesions by a human observer. Usi ... Full text Cite

Computer aid for decision to biopsy breast masses on mammography: validation on new cases.

Journal Article Acad Radiol · June 2005 Featured Publication RATIONALE AND OBJECTIVES: The purpose of this study was to validate the performance of a previously developed computer aid for breast mass classification for mammography on a new, independent database of cases not used for algorithm development. MATERIALS ... Full text Link to item Cite

The effects of gray scale image processing on digital mammography interpretation performance.

Journal Article Acad Radiol · May 2005 RATIONALE AND OBJECTIVES: To determine the effects of three image-processing algorithms on diagnostic accuracy of digital mammography in comparison with conventional screen-film mammography. MATERIALS AND METHODS: A total of 201 cases consisting of nonproc ... Full text Link to item Cite

Accuracy of segmentation of a commercial computer-aided detection system for mammography.

Journal Article Radiology · May 2005 Featured Publication PURPOSE: To assess the accuracy of segmentation in a commercially available computer-aided detection (CAD) system. MATERIALS AND METHODS: Approval for this study was obtained from the authors' institutional review board. Informed consent was not required b ... Full text Link to item Cite

Comparison of recall and cancer detection rates for immediate versus batch interpretation of screening mammograms.

Journal Article Radiology · April 2005 Featured Publication PURPOSE: To retrospectively compare recall and cancer detection rates between immediate and subsequent batch methods for interpretation of screening mammograms. MATERIALS AND METHODS: Institutional review board approval was obtained, and informed consent w ... Full text Link to item Cite

BI-RADS for sonography: positive and negative predictive values of sonographic features.

Journal Article AJR Am J Roentgenol · April 2005 Featured Publication OBJECTIVE: The purpose of this study was to assess the positive predictive value (PPV) and negative predictive value (NPV) of features described in the new sonographic BI-RADS lexicon for evaluating solid masses with known histologic diagnoses. MATERIALS A ... Full text Link to item Cite

Computer-aided detection of amorphous calcifications.

Journal Article AJR Am J Roentgenol · March 2005 Featured Publication OBJECTIVE: Computer-aided detection (CAD) systems have been used successfully to detect malignant calcifications on mammography, with sensitivities ranging from 86% to 99%. Amorphous calcifications are a subset of small indistinct calcifications of interme ... Full text Link to item Cite

Detection of primary breast carcinoma with a dedicated, large-field-of-view FDG PET mammography device: initial experience.

Journal Article Radiology · February 2005 Featured Publication PURPOSE: To prospectively assess a dedicated, large field of view positron emission tomography (PET) mammographic device for imaging primary breast carcinoma. MATERIALS AND METHODS: Institutional review board approval was obtained for this study, and all p ... Full text Link to item Cite

Computer-aided detection in screening mammography: variability in cues.

Journal Article Radiology · November 2004 Featured Publication PURPOSE: To evaluate the variability of true-positive and false-positive cues by using a commercially available computer-aided detection (CAD) system for analysis of 50 malignancies in a screening population. MATERIALS AND METHODS: Fifty breast cancers det ... Full text Link to item Cite

A clinical study of adaptive beamforming using time-delay adjustments on a 1-D array

Journal Article Proceedings of the IEEE Ultrasonics Symposium · December 1, 2003 Time-delay estimation is made using echoes from a user-selected target region, to which the transmit focus is applied to maximize signal coherence. The estimated time-delay profile is split into 2 components using a least-squares fitting: one component ind ... Cite

Accuracy of a collagen-plug biopsy site marking device deployed after stereotactic core needle breast biopsy.

Journal Article AJR Am J Roentgenol · November 2003 Featured Publication OBJECTIVE: The goal of this study was to compare the accuracy of clip placement of a collagen-plug biopsy marking device with that of the more conventional, previously evaluated metallic tissue-marking clips. SUBJECTS AND METHODS. The placement accuracy of ... Full text Link to item Cite

Accuracy of MRI in the detection of residual breast cancer after neoadjuvant chemotherapy.

Journal Article AJR Am J Roentgenol · November 2003 Featured Publication OBJECTIVE: This study was undertaken to evaluate the ability of MRI to accurately show residual primary breast malignancy in women treated with neoadjuvant chemotherapy. MATERIALS AND METHODS: Twenty-one patients with locally advanced primary breast carcin ... Full text Link to item Cite

Computer-aided detection (CAD) in screening mammography: sensitivity of commercial CAD systems for detecting architectural distortion.

Journal Article AJR Am J Roentgenol · October 2003 Featured Publication OBJECTIVE: Computer-aided detection (CAD) algorithms have successfully revealed breast masses and microcalcifications on screening mammography. The purpose of our study was to evaluate the sensitivity of commercially available CAD systems for revealing arc ... Full text Link to item Cite

Sonographic detection and sonographically guided biopsy of breast microcalcifications.

Journal Article AJR Am J Roentgenol · April 2003 Featured Publication OBJECTIVE: The purpose of this study was to evaluate the ability of sonography to depict and guide biopsies of mammographically suspicious microcalcifications and to reveal the mammographic features and histologic outcomes of lesions amenable to sonographi ... Full text Link to item Cite

Imaging-guided core needle biopsy of papillary lesions of the breast.

Journal Article AJR Am J Roentgenol · November 2002 Featured Publication OBJECTIVE: Our objective was to assess the incidence of papillary lesions of the breast diagnosed at imaging-guided core needle biopsy and the need for surgical excision after a benign diagnosis. MATERIALS AND METHODS: This retrospective study included 137 ... Full text Link to item Cite

Interpretation of digital mammograms: comparison of speed and accuracy of soft-copy versus printed-film display.

Journal Article Radiology · May 2002 Featured Publication PURPOSE: To compare the speed and accuracy of the interpretations of digital mammograms by radiologists by using printed-film versus soft-copy display. MATERIALS AND METHODS: After being trained in interpretation of digital mammograms, eight radiologists i ... Full text Link to item Cite

Malignant lesions initially subjected to short-term mammographic follow-up.

Journal Article Radiology · April 2002 Featured Publication PURPOSE: To determine whether systematically evaluated criteria for probably benign lesions were actually applied to lesions placed into that category. MATERIALS AND METHODS: A search of the mammography database yielded 295 cases that were initially follow ... Full text Link to item Cite

Sonographically guided biopsy of suspicious microcalcifications of the breast: a pilot study.

Journal Article AJR Am J Roentgenol · April 2002 Featured Publication OBJECTIVE: The purpose of this study is to evaluate the use of sonographic guidance for biopsy of mammographically detected suspicious microcalcifications. SUBJECTS AND METHODS: Twenty-three patients with suspicious microcalcifications detected on mammogra ... Full text Link to item Cite

Breast US: assessment of technical quality and image interpretation.

Journal Article Radiology · April 2002 Featured Publication PURPOSE: To determine whether ultrasonography (US) of the breast performed at a wide range of clinical practices conforms to the American College of Radiology (ACR) standards for quality and to assess the interpretations of breast sonograms. MATERIALS AND ... Full text Link to item Cite

Cross-institutional evaluation of BI-RADS predictive model for mammographic diagnosis of breast cancer.

Journal Article AJR Am J Roentgenol · February 2002 Featured Publication OBJECTIVE: Given a predictive model for identifying very likely benign breast lesions on the basis of Breast Imaging Reporting and Data System (BI-RADS) mammographic findings, this study evaluated the model's ability to generalize to a patient data set fro ... Full text Link to item Cite

Negative predictive value of sonography with mammography in patients with palpable breast lesions.

Journal Article AJR Am J Roentgenol · November 2001 Featured Publication OBJECTIVE: This study was performed to determine the negative predictive value of sonography with mammography in evaluating palpable breast lesions. MATERIALS AND METHODS: Four hundred twenty patients with 455 palpable breast lesions were retrospectively i ... Full text Link to item Cite

Artifacts and pitfalls in sonographic imaging of the breast.

Journal Article AJR Am J Roentgenol · May 2001 Featured Publication Full text Link to item Cite

The evolving role of sonography in evaluating solid breast masses.

Journal Article Semin Ultrasound CT MR · August 2000 Featured Publication Many investigators have attempted to use ultrasound imaging to differentiate benign from malignant solid breast masses. Studies have evaluated several generations of gray-scale imaging, Doppler, color Doppler, and power Doppler imaging, and several unconve ... Full text Link to item Cite

Sonography of solid breast lesions: observer variability of lesion description and assessment.

Journal Article AJR Am J Roentgenol · June 1999 Featured Publication OBJECTIVE: The purpose of this study was to measure the level of inter- and intraobserver agreement and to evaluate the causes of variability in radiologists' descriptions and assessments of sonograms of solid breast masses. MATERIALS AND METHODS: Sixty so ... Full text Link to item Cite

Effect of patient history data on the prediction of breast cancer from mammographic findings with artificial neural networks.

Journal Article Acad Radiol · January 1999 Featured Publication RATIONALE AND OBJECTIVES: The authors evaluated the contribution of medical history data to the prediction of breast cancer with artificial neural network (ANN) models based on mammographic findings. MATERIALS AND METHODS: Three ANNs were developed: The fi ... Full text Link to item Cite

Prediction of breast biopsy outcomes from mammographic findings

Journal Article COMPUTER-AIDED DIAGNOSIS IN MEDICAL IMAGING · January 1, 1999 Link to item Cite

Predictive model for the diagnosis of intraabdominal abscess.

Journal Article Acad Radiol · July 1998 Featured Publication RATIONALE AND OBJECTIVES: The authors investigated the use of an artificial neural network (ANN) to aid in the diagnosis of intraabdominal abscess. MATERIALS AND METHODS: An ANN was constructed based on data from 140 patients who underwent abdominal and pe ... Full text Link to item Cite

Predicting breast cancer invasion with artificial neural networks on the basis of mammographic features.

Journal Article Radiology · April 1997 Featured Publication PURPOSE: To evaluate whether an artificial neural network (ANN) can predict breast cancer invasion on the basis of readily available medical findings (ie, mammographic findings classified according to the American College of Radiology Breast Imaging Report ... Full text Link to item Cite

Fractal texture analysis in computer-aided diagnosis of solitary pulmonary nodules.

Journal Article Acad Radiol · February 1997 Featured Publication RATIONALE AND OBJECTIVES: The authors investigated the use of fractal texture characterization to improve the accuracy of solitary pulmonary nodule computer-aided diagnosis (CAD) systems. METHODS: Thirty chest radiographs were acquired from patients who ha ... Full text Link to item Cite

Computer-aided diagnosis of mammography using an artificial neural network: Predicting the invasiveness of breast cancers from image features

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1996 The study aimed to develop an artificial neural network (ANN) for computer-aided diagnosis of mammography. Using 9 mammographic image features and patient age, the ANN predicted whether breast lesions were benign, invasive malignant, or noninvasive maligna ... Full text Cite

Use of genetic algorithms for computer-aided diagnosis of breast cancers from image features

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1996 Purpose: In this investigation we have explored genetic algorithms as a technique to train the weights in a feed forward neural network designed to predict breast cancer based on mammographic findings and patient history. Methods: Mammograms were obtained ... Full text Cite

Breast imaging reporting and data system standardized mammography lexicon: observer variability in lesion description.

Journal Article AJR Am J Roentgenol · April 1996 Featured Publication OBJECTIVE: The American College of Radiology has recommended the Breast Imaging Reporting and Data System (BI-RADS) as a standardized scheme for describing mammographic lesions. The objective of this study was to measure inter- and intraobserver variabilit ... Full text Link to item Cite

Artificial neural network: improving the quality of breast biopsy recommendations.

Journal Article Radiology · January 1996 Featured Publication PURPOSE: To evaluate the performance and inter- and intraobserver variability of an artificial neural network (ANN) for predicting breast biopsy outcome. MATERIALS AND METHODS: Five radiologists described 60 mammographically detected lesions with the Ameri ... Full text Link to item Cite

Selenium-based digital radiography of the chest: radiologists' preference compared with film-screen radiographs.

Journal Article AJR Am J Roentgenol · December 1995 Featured Publication OBJECTIVE: A new digital thoracic radiography system (Thoravision; Philips Medical Systems, Hamburg, Germany), which uses selenium as a detector material, was evaluated for observer preference. The system has been shown to have higher detection efficiency ... Full text Link to item Cite

Computer-aided diagnosis of breast cancer: artificial neural network approach for optimized merging of mammographic features.

Journal Article Acad Radiol · October 1995 Featured Publication RATIONALE AND OBJECTIVES: An artificial neural network (ANN) approach was developed for the computer-aided diagnosis of mammography using an optimally minimized number of input features. METHODS: A backpropagation ANN merged nine input features (age plus e ... Full text Link to item Cite

Breast cancer: prediction with artificial neural network based on BI-RADS standardized lexicon.

Journal Article Radiology · September 1995 Featured Publication PURPOSE: To determine if an artificial neural network (ANN) to categorize benign and malignant breast lesions can be standardized for use by all radiologists. MATERIALS AND METHODS: An ANN was constructed based on the standardized lexicon of the Breast Ima ... Full text Link to item Cite

Scatter compensation in digital chest radiography using the posterior beam stop technique.

Journal Article Med Phys · March 1994 Featured Publication A new scatter compensation technique for computed radiography based on posterior beam stop (PBS) sampled scatter measurements and the bicubic spline interpolation technique was proposed. Using only a single exposure, both the clinical image and an array of ... Full text Link to item Cite

Observer evaluation of scatter subtraction for digital portable chest radiographs.

Journal Article Invest Radiol · August 1993 Featured Publication RATIONALE AND OBJECTIVES: The authors compared standard digital portable chest radiographs (DPCXR) to scatter-subtracted DPCXR: METHODS: Thirty DPCXR were obtained using a photostimulable phosphor digital imaging system and a posterior beam stop (PBS) tech ... Full text Link to item Cite

Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy.

Journal Article J Nucl Med · January 1993 Featured Publication To assess the correlation between myocardial perfusion, metabolism and histologic findings in patients with cardiomyopathy, we evaluated myocardial perfusion and metabolism using positron emission tomography (PET) with 13NH3 (ammonia) and 18FDG (fluoro-2-d ... Link to item Cite

An artificial neural network for estimating scatter exposures in portable chest radiography.

Journal Article Med Phys · 1993 Featured Publication An adaptive linear element (Adaline) was developed to estimate the two-dimensional scatter exposure distribution in digital portable chest radiographs (DPCXR). DPCXRs and quantitative scatter exposure measurements at 64 locations throughout the chest were ... Full text Link to item Cite

Measurement of scatter fractions in clinical bedside radiography.

Journal Article Radiology · June 1992 Featured Publication The authors present measurements of scatter fraction (SF), the ratio of scattered to total imaged photons, from clinical bedside radiographs of 102 patients. These measurements were obtained by using a new posterior beam-stop technique that does not alter ... Full text Link to item Cite

Posterior beam-stop method for scatter fraction measurement in digital radiography.

Journal Article Invest Radiol · February 1992 Featured Publication The authors presented a new posterior beam-stop (PBS) technique for measuring the ratio of scattered to total-detected photon flux (scatter fraction) in a radiographic examination while preserving the diagnostic quality of the image. The scatter measuremen ... Full text Link to item Cite

The effect of metabolic milieu on cardiac PET imaging using fluorine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers.

Journal Article J Nucl Med · August 1991 Featured Publication Cardiac PET imaging using 13N-ammonia and 18FDG was performed on 17 normal volunteers in the glucose-loaded and fasted states. PET images (glucose-loaded and fasted) were subjected to qualitative visual analysis using the descriptors: image quality, FDG bl ... Link to item Cite