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Computer-aided detection in screening mammography: variability in cues.

Publication ,  Journal Article
Baker, JA; Lo, JY; Delong, DM; Floyd, CE
Published in: Radiology
November 2004

PURPOSE: To evaluate the variability of true-positive and false-positive cues by using a commercially available computer-aided detection (CAD) system for analysis of 50 malignancies in a screening population. MATERIALS AND METHODS: Fifty breast cancers detected at screening were analyzed by using a commercially available CAD system. Mean patient age was 62.2 years. Each set of mammograms (craniocaudal and mediolateral oblique views) was digitized and analyzed by the CAD system 10 times. One radiologist compared CAD output with the location of the malignancy at mammography and determined whether each lesion was marked accurately in one mammographic view, both views, or neither. Sensitivity and reproducibility of the CAD system were determined for both case- and image-based analysis. RESULTS: Overall sensitivity of the CAD system when at least one of the two mammographic views was marked correctly (case-base sensitivity) was 82.4%. Sensitivity when each mammographic view was considered separately (image-based sensitivity) was 61.1%. For case-based analysis, variability in true-positive CAD cues was demonstrated for 14 of 50 (28%) cases. For image-based analysis, inconsistency in CAD output was observed in 33 of 100 (33%) mammographic views that contained malignancies detected at screening. However, the CAD system consistently detected 40-43 of the 50 breast cancers in each of the 10 CAD runs. Variability for false-positive marks was significantly greater than that for true-positive marks. CONCLUSION: Inconsistency was demonstrated for CAD analysis of breast cancers detected at screening. However, the CAD system was reasonably consistent in the overall number of cancers identified from run to run. Greater variability of the CAD system was also demonstrated for false-positive marks, as compared with true-positive marks.

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Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

November 2004

Volume

233

Issue

2

Start / End Page

411 / 417

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Mammography
  • Humans
  • Female
  • False Positive Reactions
  • Diagnosis, Computer-Assisted
  • Breast Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
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Baker, J. A., Lo, J. Y., Delong, D. M., & Floyd, C. E. (2004). Computer-aided detection in screening mammography: variability in cues. Radiology, 233(2), 411–417. https://doi.org/10.1148/radiol.2332031200
Baker, Jay A., Joseph Y. Lo, David M. Delong, and Carey E. Floyd. “Computer-aided detection in screening mammography: variability in cues.Radiology 233, no. 2 (November 2004): 411–17. https://doi.org/10.1148/radiol.2332031200.
Baker JA, Lo JY, Delong DM, Floyd CE. Computer-aided detection in screening mammography: variability in cues. Radiology. 2004 Nov;233(2):411–7.
Baker, Jay A., et al. “Computer-aided detection in screening mammography: variability in cues.Radiology, vol. 233, no. 2, Nov. 2004, pp. 411–17. Pubmed, doi:10.1148/radiol.2332031200.
Baker JA, Lo JY, Delong DM, Floyd CE. Computer-aided detection in screening mammography: variability in cues. Radiology. 2004 Nov;233(2):411–417.

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

November 2004

Volume

233

Issue

2

Start / End Page

411 / 417

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Mammography
  • Humans
  • Female
  • False Positive Reactions
  • Diagnosis, Computer-Assisted
  • Breast Neoplasms