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James Dundas Lane
Professor Emeritus in Psychiatry and Behavioral Sciences
Journal ArticlePsychosom Med · 2018
OBJECTIVE: Restricting insulin to lose weight is a significant problem in the clinical management of type 1 diabetes (T1D). Little is known about this behavior or how to effectively intervene. Identifying when insulin restriction occurs could allow clinici ...
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Journal ArticleDiabetes Care · November 2015
OBJECTIVE: Individuals with type 1 diabetes who restrict insulin to control weight are at high risk for diabetes-related complications and premature death. However, little is known about this behavior or how to effectively intervene. The aim of the current ...
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Journal ArticleJ Caffeine Res · May 24, 2012
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BACKGROUND: A growing body of evidence suggests that caffeinated beverages may impair chronic glucose control in type 2 diabetes. This pilot study tested the chronic effects of caffeine abstinence on glucose control in type 2 diabetic patients who were dai ...
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Journal ArticlePsychosom Med · November 2010
OBJECTIVE: To determine whether video-based coping skills (VCS) training with telephone coaching reduces psychosocial and biological markers of distress in primary caregivers of a relative with Alzheimer's disease or related dementia (ADRD). METHODS: A con ...
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Journal ArticleObesity (Silver Spring) · September 2010
The high prevalence of diabetes in African-American (AA) women has been widely assumed to be related to the greater prevalence of obesity in this group. Catecholamine release acting on central adipose tissue has been proposed to be a contributing factor. T ...
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Journal ArticlePsychosom Med · July 2009
OBJECTIVE: To explore the underlying physiology of hostility (HOST) and to test the hypothesis that HOST has a greater impact on fasting glucose in African American (AA) women than it does on AA men or white men or women, using an intravenous glucose toler ...
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Journal ArticlePsychosom Med · July 2009
OBJECTIVE: To examine whether the relationship of hostility (HOST) to fasting glucose indices is moderated by sex and race. HOST has been associated with abnormalities in glucose metabolism. Prior studies suggested that this association may be more prevale ...
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Journal ArticlePsychosom Med · January 2008
OBJECTIVE: To test the hypothesis that low socioeconomic status (SES) and the 5HTTLPR L allele are associated with increased cardiovascular reactivity (CVR) to stress in a larger sample and that SES and 5HTTLPR genotypes interact to enhance CVR to stress. ...
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Journal ArticlePsychosom Med · April 2007
OBJECTIVE: To investigate if changes in depressive symptoms would be associated with changes in glycemic control over a 12-month period in patients with Type 1 and Type 2 diabetes. METHODS: Ninety (Type 1 diabetes, n = 28; Type 2 diabetes, n = 62) patients ...
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Journal ArticleAltern Ther Health Med · 2007
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OBJECTIVES: To test a brief, non-sectarian program of meditation training for effects on perceived stress and negative emotion, and to determine effects of practice frequency and test the moderating effects of neuroticism (emotional lability) on treatment ...
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Journal ArticleEndocr Pract · 2007
OBJECTIVE: To test whether caffeine administered in coffee increases postprandial hyperglycemia in patients with type 2 diabetes who are habitual coffee drinkers. METHODS: The study used a within-subject, double-blind, placebo-controlled experimental desig ...
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Journal ArticlePsychosom Med · 2006
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OBJECTIVE: Psychosocial factors are associated with increased morbidity and mortality in healthy and clinical populations. Behavioral interventions are needed to train the large number of people in the community setting who are affected by stressors to use ...
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Journal ArticleDiabetes Res Clin Pract · July 2005
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UNLABELLED: Several recent studies have suggested that depression is related to poorer glycemic control in patients with type 1 diabetes, but not in type 2 diabetes. We hypothesize that complexity of self-care regimen rather than the type of diabetes, is m ...
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Journal ArticleSouth Med J · November 2004
OBJECTIVES: Improving diabetes and blood pressure control decreases the incidence and progression of microvascular disease. Likewise, screening for microvascular complications is beneficial in the early detection and treatment of these disorders. However, ...
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Journal ArticleNurs Res · 2004
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BACKGROUND: Many common medical, surgical, and diagnostic procedures performed for conscious patients can be accompanied by significant anxiety. Mind-body-spirit interventions could serve as useful adjunctive treatments for the reduction of stress. OBJECTI ...
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Journal ArticleCardiol Rev · 2003
We studied the relationship between mood and mood shift immediately before percutaneous coronary intervention (PCI) and 3 end points: total ischemic burden during PCI, adverse cardiac end points (ACE) after PCI, and death by 6-month follow up. Patients (n ...
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Journal ArticleDiabetes Care · May 2002
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OBJECTIVE: The present study was designed to determine whether hostility is differentially related to measures of glucose metabolism in African-Americans and Caucasians. RESEARCH DESIGN AND METHODS: The relationship of hostility, as measured by a subset of ...
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Journal ArticleDiabetes Care · January 2002
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OBJECTIVE: There is conflicting evidence regarding the utility of stress management training in the treatment of diabetes. The few studies that have shown a therapeutic effect of stress management have used time-intensive individual therapy. Unfortunately, ...
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Journal ArticlePsychosom Med · 2002
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OBJECTIVE: This study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate, urinary excretion of epinephrine, norepinephrine, and cortisol, and subjective measures of stress during normal activities at work and ...
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Journal ArticlePersonality and Social Psychology Bulletin · January 1, 2002
The current study utilized a within-subject, experience sampling methodology (ESM) to examine the relationship between neuroticism (N) and physical symptom reports. Individuals with type 2 diabetes monitored diabetes-related symptoms, rated negative and po ...
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Journal ArticleAm Heart J · November 2001
BACKGROUND: Patients undergoing percutaneous coronary intervention (PCI) for unstable coronary syndromes have substantial emotional and spiritual distress that may promote procedural complications. Noetic (nonpharmacologic) therapies may reduce anxiety, pa ...
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Journal ArticleNicotine Tob Res · May 2001
Most studies of cigarette smoking and smoking cessation have focused on the psychopharmacological effects of nicotine; relatively few have explored the role of sensory aspects of cigarette smoke. Sensory aspects of cigarette smoke play a role in the mainte ...
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Journal ArticlePsychosom Med · 2001
OBJECTIVE: The diabetes literature contains conflicting evidence on the relationship between depression and glycemic control. This may be due, in part, to the fact that past studies failed to distinguish between patients with type 1 and type 2 diabetes. Be ...
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Journal ArticleDiabetes Care · September 2000
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OBJECTIVE: To determine whether traits of normal personality are associated with variations in glycemic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A longitudinal cohort study was conducted using data from 105 type 2 diabetic pat ...
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Journal ArticlePhysiol Behav · August 1998
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The effects of brief caffeine deprivation on vigilance performance, mood, and symptoms of caffeine withdrawal were studied in habitual coffee drinkers. Thirty male and female coffee drinkers were tested twice at midday (1130 to 1330 hours) after mornings i ...
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Journal ArticlePhysiol Behav · January 1998
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When two tones of slightly different frequency are presented separately to the left and right ears the listener perceives a single tone that varies in amplitude at a frequency equal to the frequency difference between the two tones, a perceptual phenomenon ...
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Journal ArticlePsychosom Med · 1998
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OBJECTIVE: The study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate during workday activities. METHODS: Healthy, nonsmoking, habitual coffee drinkers (N = 21) received daily doses of 100 mg and 500 mg of ...
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Journal ArticlePhysiol Behav · December 31, 1997
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The effects of short-term caffeine deprivation on mood, withdrawal symptoms and psychomotor performance were studied in habitual coffee drinkers. Thirty-one male and female coffee drinkers were tested twice at midday (1130 to 1330 h) 4 h after double-blind ...
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Journal ArticleDiabetes Care · October 1997
OBJECTIVE: Insulin lispro is a rapid-acting analog of human insulin that can be used to target the postprandial rise in plasma glucose. We designed an open-label randomized crossover study of type 2 diabetic patients with secondary failure of sulfonylurea ...
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Journal ArticlePharmacol Biochem Behav · September 1997
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The effects of short-term deprivation of caffeinated beverages on mood, withdrawal symptoms, and psychomotor performance were studied in habitual coffee drinkers. Twenty-four male and female coffee drinkers were tested at midday (1130-1330 h) under two con ...
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Journal ArticlePhysiol Behav · November 1996
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Cigarette smoke contains numerous oxygen free radicals that may be important in smoking-related disease pathogenesis. These free radicals may overwhelm antioxidant defenses and produce a condition of oxidative stress that can result in damage to DNA and ot ...
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Journal ArticlePsychophysiology · January 1996
Blood pressure is one of the most commonly recorded functions in physiology and medicine, and it has become a major variable in recent psychophysiological and behavioral medicine research. Many methods have been developed for the measurement of blood press ...
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Journal ArticleExperimental and Clinical Psychopharmacology · January 1, 1996
Coffee drinking may serve as a cue for cigarette smoking. The association of coffee drinking and cigarette smoking in the natural environment was studied in 6 participants who recorded every instance of ad lib cigarette smoking and coffee drinking for 4 co ...
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Journal ArticleExperimental and Clinical Psychopharmacology · January 1, 1995
The effects of cigarette smoking on pain perception were evaluated in 18 healthy smokers. Thermal pain stimuli were used to assess pain detection threshold and tolerance and to collect subjective ratings of the intensity and unpleasantness of painful stimu ...
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Journal ArticleExperimental and Clinical Psychopharmacology · January 1, 1995
The effects of changes in daily caffeine intake on cigarette smoking were investigated. Forty cigarette smokers consumed caffeine ad lib on a baseline day then consumed controlled multiple doses of caffeine (100 mg and 500 mg per day) for two-day trials. S ...
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Journal ArticleNeuropsychopharmacology · December 1994
Co-administration of an agonist with an antagonist may regulate receptor activation, resulting in relief of withdrawal symptoms and blockade of drug reward. In one study, 12 smokers rated the rewarding effects of cigarette smoke after separate and combined ...
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Journal ArticlePsychosom Med · 1994
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The effect of caffeine on neuroendocrine stress responses in the workplace was studied in 14 habitual coffee drinkers. Urinary catecholamine and cortisol levels were measured on 2 study days, in a 4-hour interval from morning until noon, while participants ...
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Journal ArticlePsychosom Med · 1994
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The consumption of caffeinated beverages has been linked to elevated serum cholesterol and an increased risk of coronary disease, although the relationships are inconsistent across studies and remain controversial. The effect of caffeine on cholesterol and ...
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Journal ArticleExperimental and Clinical Psychopharmacology · January 1, 1994
Separate and combined effects of nicotine and the nicotinic antagonist mecamylamine were studied. Twelve smokers rated test cigarettes after administration of mecamylamine versus placebo capsules and nicotine versus nonnicotine preload. Smoking withdrawal ...
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Journal ArticleDiabetes Care · August 1993
OBJECTIVE: To examine the benefits of relaxation training for patients with NIDDM and to investigate individual differences that could predict a positive response to relaxation training. RESEARCH DESIGN AND METHODS: Thirty-eight subjects with NIDDM were tr ...
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Journal ArticleDrug Development and Industrial Pharmacy · January 1, 1993
A new transdermal nicotine delivery system (TBS-NCT)was investigated in laboratory and clinical studies with healthy cigarette smokers. Plasma nicotine concentration time profiles were characterized during and after 24-hr application of three doses of TBS- ...
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Journal ArticlePsychophysiology · July 1992
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The parasympathetic nervous system provides mechanisms that could attenuate sympathetically mediated heart rate stress responses and might have even more general antagonistic actions on stress reactivity. Individuals characterized by higher levels of paras ...
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Journal ArticleBehav Pharmacol · June 1992
This study tested the hypothesis that prolonged exposure to high doses of cocaine would produce tolerance to the reinforcing effects of cocaine. We determined the rate of administration of low doses of cocaine in rats and then exposed these subjects to hig ...
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Journal ArticleCirculation · June 1992
BACKGROUND: Prior research has suggested a weaker parasympathetic antagonism of sympathetic effects on the heart in type A (coronary-prone) men. To confirm this phenomenon and extend our understanding of it, we investigated the effects of prior muscarinic ...
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Journal ArticleEur J Clin Pharmacol · 1992
Increases in the levels of sex steroids due to pregnancy or oral contraceptive steroid use are known to decrease significantly the rate at which caffeine is eliminated from the body. An investigation has now been made into whether the changes in sex steroi ...
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Journal ArticlePsychosom Med · 1990
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The effects of a moderate dose of caffeine on cardiovascular and neuroendocrine stress reactivity were examined in 25 healthy male subjects selected as habitual or light consumers of caffeine. Measurements were taken under resting conditions before and aft ...
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Journal ArticlePsychophysiology · January 1989
This study examined the interaction of race and parental history of hypertension on patterns of cardiovascular responses among women. Two stressors were used that produce different patterns of cardiovascular reactivity: mental arithmetic, primarily a beta- ...
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Journal ArticlePsychosom Med · 1989
Although habitual caffeine users ingest the drug repeatedly throughout each day, the persistence of caffeine's known cardiovascular effects with such repeated use has not been investigated. Blood pressure and heart rate were measured under resting conditio ...
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Journal ArticleHealth Psychol · 1989
This study investigated cardiovascular responses to two stressors known to elicit either beta-adrenergic (mental arithmetic) or alpha-adrenergic (forehead cold pressor) reactivity in Black and White men. Participants in each group were selected for presenc ...
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Journal ArticleNeuropsychopharmacology · December 1988
beta-Adrenergic hyperreactivity has been proposed as a pathogenic mechanism of increased coronary risk in Type A individuals. This study compared the effects of propranolol, diazepam, and placebo on cardiovascular and neuroendocrine responses to a stressfu ...
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Journal ArticleInt J Psychophysiol · June 1988
One hypothesized mechanism for the higher rates and greater severity of essential hypertension among blacks is that this group is particularly susceptible to stress-induced beta-adrenergically mediated cardiovascular hyperreactivity. In this study, we comp ...
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Journal ArticleHealth Psychol · 1988
To determine whether there are basic biological differences between Type A and Type B men, we compared hemodynamic, electrophysiologic and neuroendocrine responses to equipotent doses of isoproterenol (ISO) and norepinephrine (NE) in 10 Type A and 10 Type ...
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Journal ArticlePsychosom Med · 1988
The mechanisms responsible for the higher incidence of essential hypertension in blacks than in whites are the object of much research attention. One hypothesis is that the development of hypertension in blacks is associated with exaggerated blood pressure ...
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Journal ArticlePsychosom Med · 1987
We studied the relationship between presence of Type A behavior pattern and glycemic response to stress in children with insulin dependent diabetes mellitus (IDDM). Twelve male (six Type A and six Type B) and nine female (four Type A and five Type B) insul ...
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Journal ArticleJ Psychosom Res · 1987
Beta-adrenergic sympathetic nervous system (SNS) hyperresponsivity to behavioral stress may play a role in the onset of sustained high blood pressure--particularly in persons with a parental history of hypertension. Although hypertension is extremely preva ...
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Journal ArticleHealth Psychol · 1986
The purpose of this study was to determine the effects of Type A behavior and family history of hypertension on cardiovascular reactivity to mental stress in a group of employed black women. Measures of heart rate and of systolic blood pressure (SBP) and d ...
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Journal ArticleJ Human Stress · 1985
The Type A behavior pattern and the inhibited power motive have been implicated in the development of coronary heart disease (CHD). Since it is widely believed that enhanced cardiovascular responsivity may be one mechanism by which individuals develop CHD, ...
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Journal ArticlePsychosom Med · October 1983
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Caffeine and psychologic stress have similar physiologic effects. Moderate doses of caffeine were found to elevate blood pressure in healthy, young males during periods of rest and stress. Blood pressure during stress was also significantly higher after ca ...
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Journal ArticleJ Neurochem · May 1983
The turnover rates of aspartate, gamma-aminobutyric acid (GABA), glutamate, glutamine, alanine, serine, and glycine were measured in five regions of rat cerebellum. Turnover rates of the putative neurotransmitters (aspartate, glutamate, and GABA) were 2-20 ...
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Journal ArticleScience · October 29, 1982
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Qualitatively distinct patterns of cardiovascular and neuroendocrine responses were observed in male college students during mental work and during sensory intake task performance. During mental work, Type A (coronary-prone) subjects showed greater muscle ...
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Journal ArticleDiabetes Care · 1982
Non-insulin-dependent diabetic subjects had abnormally raised in vitro platelet aggregation rates to collagen or ristocetin when thought to be "well-controlled" on diet alone but shown to have raised basal plasma glucose levels. Basal normoglycemia, induce ...
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