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Pharmacokinetics of a transdermal nicotine patch compared to nicotine gum

Publication ,  Journal Article
Lane, JD; Westman, EC; Ripka, GV; Wu, J; Chiang, CC; Rose, JE
Published in: Drug Development and Industrial Pharmacy
January 1, 1993
Published version (DOI)

A new transdermal nicotine delivery system (TBS-NCT)was investigated in laboratory and clinical studies with healthy cigarette smokers. Plasma nicotine concentration time profiles were characterized during and after 24-hr application of three doses of TBS-NCT and during and after a 6-hr regimen of nicotine polacrilex gum. Pharmacokinetic analysis revealed dose-related plasma concentrations for transdermal treatments, bracketing the concentrations obtained from nicotine gum. The TBS-NCT system was also well tolerated during a subsequent 4-week open trial and demonstrated a 40% success rate for smoking cessation during the course of the trial. Overall, the TBS-NCT system appears suitable for once-daily application as an aid in smoking cessation treatments. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Duke Scholars

Jed Eugene Rose
Author Jed Eugene Rose Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
James Dundas Lane
Author James Dundas Lane Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
Eric Charles Westman
Author Eric Charles Westman Medicine, General Internal Medicine

Published In

Drug Development and Industrial Pharmacy

DOI

10.3109/03639049309069337

ISSN

0363-9045

Publication Date

January 1, 1993

Volume

19

Issue

16

Start / End Page

1999 / 2010

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Lane, J. D., Westman, E. C., Ripka, G. V., Wu, J., Chiang, C. C., & Rose, J. E. (1993). Pharmacokinetics of a transdermal nicotine patch compared to nicotine gum. Drug Development and Industrial Pharmacy, 19(16), 1999–2010. https://doi.org/10.3109/03639049309069337
Lane, J. D., E. C. Westman, G. V. Ripka, J. Wu, C. C. Chiang, and J. E. Rose. “Pharmacokinetics of a transdermal nicotine patch compared to nicotine gum.” Drug Development and Industrial Pharmacy 19, no. 16 (January 1, 1993): 1999–2010. https://doi.org/10.3109/03639049309069337.
Lane JD, Westman EC, Ripka GV, Wu J, Chiang CC, Rose JE. Pharmacokinetics of a transdermal nicotine patch compared to nicotine gum. Drug Development and Industrial Pharmacy. 1993 Jan 1;19(16):1999–2010.
Lane, J. D., et al. “Pharmacokinetics of a transdermal nicotine patch compared to nicotine gum.” Drug Development and Industrial Pharmacy, vol. 19, no. 16, Jan. 1993, pp. 1999–2010. Scopus, doi:10.3109/03639049309069337.
Lane JD, Westman EC, Ripka GV, Wu J, Chiang CC, Rose JE. Pharmacokinetics of a transdermal nicotine patch compared to nicotine gum. Drug Development and Industrial Pharmacy. 1993 Jan 1;19(16):1999–2010.
Journal cover image

Published In

Drug Development and Industrial Pharmacy

DOI

10.3109/03639049309069337

ISSN

0363-9045

Publication Date

January 1, 1993

Volume

19

Issue

16

Start / End Page

1999 / 2010

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences