Scholars@Duke
Jennifer H. Saullo

Jennifer H. Saullo

Associate Professor of Medicine
Medicine, Infectious Diseases
jennifer.horan@duke.edu
DUMC 102359, Hanes House Rm 252, Durham, NC 27710
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Selected Publications

Cytomegalovirus Therapy: Role of Letermovir in Prophylaxis and Treatment in Transplant Recipients.

Journal Article Annu Rev Med · January 27, 2023 Cytomegalovirus (CMV) is a common viral pathogen in the transplant population and is associated with significant morbidity and mortality. CMV prevention is paramount; however, selecting the best preventive strategy depends on many factors including donor-r ... Full text Link to item Cite

Cytomegalovirus prevention in thoracic organ transplantation: A single-center evaluation of letermovir prophylaxis.

Journal Article J Heart Lung Transplant · April 2022 BACKGROUND: Cytomegalovirus (CMV) infection is common following thoracic organ transplantation and causes substantial morbidity and mortality. Letermovir is a novel antiviral agent used off-label in this population for CMV prevention. Our goal was to under ... Full text Link to item Cite

Oral and Inhaled Ribavirin Treatment for Respiratory Syncytial Virus Infection in Lung Transplant Recipients.

Journal Article Transplantation · June 2020 BACKGROUND: Respiratory syncytial virus (RSV) infection in lung transplant recipients (LTRs) causes mortality rates of 10%-20% despite antiviral therapy. Ribavirin (RBV) has been used to treat RSV-infected LTRs with limited data. METHODS: A retrospective s ... Full text Link to item Cite

Cytomegalovirus in Allogeneic Hematopoietic Transplantation: Impact on Costs and Clinical Outcomes Using a Preemptive Strategy.

Journal Article Biol Blood Marrow Transplant · March 2020 Cytomegalovirus (CMV) results in significant morbidity and mortality following hematopoietic cell transplantation (HCT). Establishing the cost and clinical impact is imperative to the selection of appropriate CMV preventative strategies. This is a retrospe ... Full text Link to item Cite

Updates on Nocardia Skin and Soft Tissue Infections in Solid Organ Transplantation.

Journal Article Curr Infect Dis Rep · June 21, 2019 PURPOSE OF REVIEW: Due to their immunocompromised status, solid organ transplant (SOT) recipients are at risk for Nocardia infections. These infections often necessitate early invasive diagnostics alongside prolonged, often combination antimicrobial therap ... Full text Link to item Cite

Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis.

Journal Article Antimicrob Agents Chemother · March 2019 Treatment options for drug-resistant cytomegalovirus (CMV) are limited. Letermovir is a novel antiviral recently approved for CMV prophylaxis following hematopoietic cell transplantation, but its efficacy in other settings is unknown. We recently used lete ... Full text Open Access Link to item Cite

Nocardia infections in the transplanted host.

Journal Article Transpl Infect Dis · August 2018 BACKGROUND: Nocardia are uncommon pathogens that disproportionately afflict the immunocompromised host. Epidemiology and outcome data of Nocardia infections in transplant recipients are limited. METHODS: We performed a retrospective chart review of all pat ... Full text Link to item Cite

Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD.

Journal Article J Pediatr Hematol Oncol · August 2018 Brincidofovir (CMX001) is an oral agent with activity against double-strand DNA viruses undergoing clinical trials in immunocompromised patients. We report a patient clinically diagnosed with brincidofovir-related gastrointestinal (GI) toxicity and his his ... Full text Link to item Cite

Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.

Journal Article Clin Infect Dis · April 1, 2017 BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recen ... Full text Link to item Cite

Increasing Nocardia Incidence Associated with Bronchiectasis at a Tertiary Care Center.

Journal Article Ann Am Thorac Soc · March 2017 RATIONALE: Nocardia is a genus of pathogens that most commonly afflict immunocompromised hosts but may be an emerging infection among persons with bronchiectasis. OBJECTIVES: To examine the epidemiology and clinical presentation of adult patients with Noca ... Full text Link to item Cite

Hepatitis B core antibody-positive donors in cardiac transplantation: a single-center experience.

Journal Article Transpl Infect Dis · October 2014 Hepatitis B virus (HBV) core antibody (HBcAb)-positive donors are increasingly utilized in solid organ transplantation. We report a single center's experience in cardiac transplantation with 18 HBcAb-positive donors. Available follow-up on recipients of ca ... Full text Link to item Cite

Complexities associated with the molecular and proteomic identification of Paecilomyces species in the clinical mycology laboratory.

Journal Article Med Mycol · July 2014 Paecilomyces species are emerging fungal pathogens. Morphological identifications are complicated by similarities among the members of the P. variotii complex as well as to some Rasamsonia and Hamigera species. The purpose of this study was to compare matr ... Full text Link to item Cite

Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors.

Journal Article Am J Transplant · May 2014 Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative, but existing regimens rely on steroids and have higher rejection rates. Experimentally, donor bone marrow and si ... Full text Link to item Cite

Fungal meningitis

Chapter · April 21, 2014 Cite

High performance liquid chromatography-mass spectrometry assay for polymyxin B1 and B2 in human plasma.

Journal Article Ther Drug Monit · August 2012 BACKGROUND: Polymyxin B is an old antibiotic with increasing clinical relevance in the treatment of multidrug-resistant Gram-negative bacterial infections. However, current dosing regimens are largely empiric as clinical pharmacological characterization of ... Full text Link to item Cite

Cytomegalovirus Therapy: Role of Letermovir in Prophylaxis and Treatment in Transplant Recipients.

Journal Article Annu Rev Med · January 27, 2023 Cytomegalovirus (CMV) is a common viral pathogen in the transplant population and is associated with significant morbidity and mortality. CMV prevention is paramount; however, selecting the best preventive strategy depends on many factors including donor-r ... Full text Link to item Cite

Cytomegalovirus prevention in thoracic organ transplantation: A single-center evaluation of letermovir prophylaxis.

Journal Article J Heart Lung Transplant · April 2022 BACKGROUND: Cytomegalovirus (CMV) infection is common following thoracic organ transplantation and causes substantial morbidity and mortality. Letermovir is a novel antiviral agent used off-label in this population for CMV prevention. Our goal was to under ... Full text Link to item Cite

Oral and Inhaled Ribavirin Treatment for Respiratory Syncytial Virus Infection in Lung Transplant Recipients.

Journal Article Transplantation · June 2020 BACKGROUND: Respiratory syncytial virus (RSV) infection in lung transplant recipients (LTRs) causes mortality rates of 10%-20% despite antiviral therapy. Ribavirin (RBV) has been used to treat RSV-infected LTRs with limited data. METHODS: A retrospective s ... Full text Link to item Cite

Cytomegalovirus in Allogeneic Hematopoietic Transplantation: Impact on Costs and Clinical Outcomes Using a Preemptive Strategy.

Journal Article Biol Blood Marrow Transplant · March 2020 Cytomegalovirus (CMV) results in significant morbidity and mortality following hematopoietic cell transplantation (HCT). Establishing the cost and clinical impact is imperative to the selection of appropriate CMV preventative strategies. This is a retrospe ... Full text Link to item Cite

Updates on Nocardia Skin and Soft Tissue Infections in Solid Organ Transplantation.

Journal Article Curr Infect Dis Rep · June 21, 2019 PURPOSE OF REVIEW: Due to their immunocompromised status, solid organ transplant (SOT) recipients are at risk for Nocardia infections. These infections often necessitate early invasive diagnostics alongside prolonged, often combination antimicrobial therap ... Full text Link to item Cite

Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis.

Journal Article Antimicrob Agents Chemother · March 2019 Treatment options for drug-resistant cytomegalovirus (CMV) are limited. Letermovir is a novel antiviral recently approved for CMV prophylaxis following hematopoietic cell transplantation, but its efficacy in other settings is unknown. We recently used lete ... Full text Open Access Link to item Cite

Nocardia infections in the transplanted host.

Journal Article Transpl Infect Dis · August 2018 BACKGROUND: Nocardia are uncommon pathogens that disproportionately afflict the immunocompromised host. Epidemiology and outcome data of Nocardia infections in transplant recipients are limited. METHODS: We performed a retrospective chart review of all pat ... Full text Link to item Cite

Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD.

Journal Article J Pediatr Hematol Oncol · August 2018 Brincidofovir (CMX001) is an oral agent with activity against double-strand DNA viruses undergoing clinical trials in immunocompromised patients. We report a patient clinically diagnosed with brincidofovir-related gastrointestinal (GI) toxicity and his his ... Full text Link to item Cite

Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.

Journal Article Clin Infect Dis · April 1, 2017 BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recen ... Full text Link to item Cite

Increasing Nocardia Incidence Associated with Bronchiectasis at a Tertiary Care Center.

Journal Article Ann Am Thorac Soc · March 2017 RATIONALE: Nocardia is a genus of pathogens that most commonly afflict immunocompromised hosts but may be an emerging infection among persons with bronchiectasis. OBJECTIVES: To examine the epidemiology and clinical presentation of adult patients with Noca ... Full text Link to item Cite

Hepatitis B core antibody-positive donors in cardiac transplantation: a single-center experience.

Journal Article Transpl Infect Dis · October 2014 Hepatitis B virus (HBV) core antibody (HBcAb)-positive donors are increasingly utilized in solid organ transplantation. We report a single center's experience in cardiac transplantation with 18 HBcAb-positive donors. Available follow-up on recipients of ca ... Full text Link to item Cite

Complexities associated with the molecular and proteomic identification of Paecilomyces species in the clinical mycology laboratory.

Journal Article Med Mycol · July 2014 Paecilomyces species are emerging fungal pathogens. Morphological identifications are complicated by similarities among the members of the P. variotii complex as well as to some Rasamsonia and Hamigera species. The purpose of this study was to compare matr ... Full text Link to item Cite

Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors.

Journal Article Am J Transplant · May 2014 Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative, but existing regimens rely on steroids and have higher rejection rates. Experimentally, donor bone marrow and si ... Full text Link to item Cite

Fungal meningitis

Chapter · April 21, 2014 Cite

High performance liquid chromatography-mass spectrometry assay for polymyxin B1 and B2 in human plasma.

Journal Article Ther Drug Monit · August 2012 BACKGROUND: Polymyxin B is an old antibiotic with increasing clinical relevance in the treatment of multidrug-resistant Gram-negative bacterial infections. However, current dosing regimens are largely empiric as clinical pharmacological characterization of ... Full text Link to item Cite

Acute renal failure: Overview of current and potential therapies

Journal Article Formulary · August 1, 2000 Although numerous therapies have been used for the treatment and prevention of acute renal failure (ARF), none has been successful in reducing mortality. Agents commonly used in the management of ARF include mann tol, loop and thiazide diuretics, and dopam ... Cite

A time-kill evaluation of clarithromycin and azithromycin against two extracellular pathogens and the development of resistance.

Journal Article Ann Pharmacother · December 1999 OBJECTIVE: To determine the activity of clarithromycin, its metabolite (14-hydroxyclarithromycin), and azithromycin against Haemophilus influenzae and Staphylococcus aureus using time-kill methodology and to evaluate the susceptibility of the organisms fol ... Full text Link to item Cite