Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Nocardia infections in the transplanted host.

Publication ,  Journal Article
Hemmersbach-Miller, M; Stout, JE; Woodworth, MH; Cox, GM; Saullo, JL
Published in: Transpl Infect Dis
August 2018

BACKGROUND: Nocardia are uncommon pathogens that disproportionately afflict the immunocompromised host. Epidemiology and outcome data of Nocardia infections in transplant recipients are limited. METHODS: We performed a retrospective chart review of all patients at Duke University Hospital with a history of solid organ transplant (SOT) or hematopoietic cell transplant (HCT) and at least one positive culture for Nocardia between 1996 and 2013. Our aim was to describe the epidemiology and outcomes of Nocardia infections in the transplanted host. RESULTS: During the 18-year study period, 51 patients (14 HCT and 37 SOT recipients) had Nocardia infection. Nocardia incidence was stable during the study period in all populations except heart transplants, whose incidence declined. Infection occurred earlier in the HCT group than the SOT group (median time to diagnosis of 153 and 370 days, respectively). In both groups, the most common site involved was the lung. Outcomes were overall poor, especially in the HCT group with a cure rate of 29%. Heart transplant recipients had significantly better overall survival (P < .05) than other patients. Trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis did not provide complete protection from Nocardia infections, nor did it appear to select for resistant Nocardia isolates. CONCLUSIONS: Infections with Nocardia are typically a late post-transplant complication. The use of TMP-SMX prophylaxis was not associated with TMP-SMX-resistant Nocardia. Overall outcomes remain poor.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

August 2018

Volume

20

Issue

4

Start / End Page

e12902

Location

Denmark

Related Subject Headings

  • Young Adult
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Treatment Outcome
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Organ Transplantation
  • Nocardia Infections
  • Nocardia
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hemmersbach-Miller, M., Stout, J. E., Woodworth, M. H., Cox, G. M., & Saullo, J. L. (2018). Nocardia infections in the transplanted host. Transpl Infect Dis, 20(4), e12902. https://doi.org/10.1111/tid.12902
Hemmersbach-Miller, Marion, Jason E. Stout, Michael H. Woodworth, Gary M. Cox, and Jennifer L. Saullo. “Nocardia infections in the transplanted host.Transpl Infect Dis 20, no. 4 (August 2018): e12902. https://doi.org/10.1111/tid.12902.
Hemmersbach-Miller M, Stout JE, Woodworth MH, Cox GM, Saullo JL. Nocardia infections in the transplanted host. Transpl Infect Dis. 2018 Aug;20(4):e12902.
Hemmersbach-Miller, Marion, et al. “Nocardia infections in the transplanted host.Transpl Infect Dis, vol. 20, no. 4, Aug. 2018, p. e12902. Pubmed, doi:10.1111/tid.12902.
Hemmersbach-Miller M, Stout JE, Woodworth MH, Cox GM, Saullo JL. Nocardia infections in the transplanted host. Transpl Infect Dis. 2018 Aug;20(4):e12902.
Journal cover image

Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

August 2018

Volume

20

Issue

4

Start / End Page

e12902

Location

Denmark

Related Subject Headings

  • Young Adult
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Treatment Outcome
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Organ Transplantation
  • Nocardia Infections
  • Nocardia
  • Middle Aged