Scholars@Duke
Jennifer Leigh Ingram

Jennifer Leigh Ingram

Associate Professor in Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
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Selected Publications

Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome.

Journal Article Surg Obes Relat Dis · January 2024 BACKGROUND: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery. OBJECTIVES: The incidence of short-term major adverse cardiovascular events (MACE) in pa ... Full text Link to item Cite

Altered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness.

Journal Article Front Immunol · 2024 INTRODUCTION: Environmental exposures and experimental manipulations can alter the ontogenetic composition of tissue-resident macrophages. However, the impact of these alterations on subsequent immune responses, particularly in allergic airway diseases, re ... Full text Link to item Cite

Vertical sleeve gastrectomy associates with airway hyperresponsiveness in a murine model of allergic airway disease and obesity.

Journal Article Front Endocrinol (Lausanne) · 2023 INTRODUCTION: Asthma is a chronic airway inflammatory disease marked by airway inflammation, remodeling and hyperresponsiveness to allergens. Allergic asthma is normally well controlled through the use of beta-2-adrenergic agonists and inhaled corticostero ... Full text Open Access Link to item Cite

Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity.

Journal Article J Asthma Allergy · 2023 20 million adults and 4.2 million children in the United States have asthma, a disease resulting in inflammation and airway obstruction in response to various factors, including allergens and pollutants and nonallergic triggers. Obesity, another highly pre ... Full text Open Access Link to item Cite

Does hand stiffness reflect internal organ fibrosis in diabetes mellitus?

Journal Article Front Clin Diabetes Healthc · 2023 Fibrosis leads to irreversible stiffening of tissue and loss of function, and is a common pathway leading to morbidity and mortality in chronic disease. Diabetes mellitus (both type 1 and type 2 diabetes) are associated with significant fibrosis in interna ... Full text Open Access Link to item Cite

Quantification of joint mobility limitation in adult type 1 diabetes.

Journal Article Front Endocrinol (Lausanne) · 2023 AIMS: Diabetic cheiroarthropathies limit hand mobility due to fibrosis and could be markers of a global profibrotic trajectory. Heterogeneity in definitions and lack of a method to measure it complicate studying associations with organ involvement and trea ... Full text Open Access Link to item Cite

Corrigendum: Quantification of joint mobility limitation in adult type 1 diabetes.

Journal Article Front Endocrinol (Lausanne) · 2023 [This corrects the article DOI: 10.3389/fendo.2023.1238825.]. ... Full text Open Access Link to item Cite

Effects of biological therapies on patients with Type-2 high asthma and comorbid obesity.

Journal Article Front Pharmacol · 2023 Over 20 million adults and 6 million children in the United States (US) have asthma, a chronic respiratory disease characterized by airway inflammation, bronchoconstriction, and mucus hypersecretion. Obesity, another highly prevalent disease in the US, is ... Full text Link to item Cite

3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension.

Journal Article Matrix Biol · August 2022 Pulmonary hypertension (PH) comprises a diverse group of disorders that share a common pathway of pulmonary vascular remodeling leading to right ventricular failure. Development of anti-remodeling strategies is an emerging frontier in PH therapeutics that ... Full text Open Access Link to item Cite

Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.

Journal Article Respir Res · May 24, 2022 BACKGROUND: Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that is increased in obesity is leptin. We hypot ... Full text Open Access Link to item Cite

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

Journal Article Lancet Respir Med · December 2021 Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the ... Full text Open Access Link to item Cite

The Gut/Lung Microbiome Axis in Obesity, Asthma, and Bariatric Surgery: A Literature Review.

Journal Article Obesity (Silver Spring) · April 2021 Mounting evidence suggests that obesity, parameters of metabolic syndrome, and asthma are significantly associated. Interestingly, these conditions are also associated with microbiome dysbiosis, notably in the airway microbiome for patients with asthma and ... Full text Open Access Link to item Cite

Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome.

Journal Article Surg Obes Relat Dis · January 2024 BACKGROUND: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery. OBJECTIVES: The incidence of short-term major adverse cardiovascular events (MACE) in pa ... Full text Link to item Cite

Altered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness.

Journal Article Front Immunol · 2024 INTRODUCTION: Environmental exposures and experimental manipulations can alter the ontogenetic composition of tissue-resident macrophages. However, the impact of these alterations on subsequent immune responses, particularly in allergic airway diseases, re ... Full text Link to item Cite

Vertical sleeve gastrectomy associates with airway hyperresponsiveness in a murine model of allergic airway disease and obesity.

Journal Article Front Endocrinol (Lausanne) · 2023 INTRODUCTION: Asthma is a chronic airway inflammatory disease marked by airway inflammation, remodeling and hyperresponsiveness to allergens. Allergic asthma is normally well controlled through the use of beta-2-adrenergic agonists and inhaled corticostero ... Full text Open Access Link to item Cite

Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity.

Journal Article J Asthma Allergy · 2023 20 million adults and 4.2 million children in the United States have asthma, a disease resulting in inflammation and airway obstruction in response to various factors, including allergens and pollutants and nonallergic triggers. Obesity, another highly pre ... Full text Open Access Link to item Cite

Does hand stiffness reflect internal organ fibrosis in diabetes mellitus?

Journal Article Front Clin Diabetes Healthc · 2023 Fibrosis leads to irreversible stiffening of tissue and loss of function, and is a common pathway leading to morbidity and mortality in chronic disease. Diabetes mellitus (both type 1 and type 2 diabetes) are associated with significant fibrosis in interna ... Full text Open Access Link to item Cite

Quantification of joint mobility limitation in adult type 1 diabetes.

Journal Article Front Endocrinol (Lausanne) · 2023 AIMS: Diabetic cheiroarthropathies limit hand mobility due to fibrosis and could be markers of a global profibrotic trajectory. Heterogeneity in definitions and lack of a method to measure it complicate studying associations with organ involvement and trea ... Full text Open Access Link to item Cite

Corrigendum: Quantification of joint mobility limitation in adult type 1 diabetes.

Journal Article Front Endocrinol (Lausanne) · 2023 [This corrects the article DOI: 10.3389/fendo.2023.1238825.]. ... Full text Open Access Link to item Cite

Effects of biological therapies on patients with Type-2 high asthma and comorbid obesity.

Journal Article Front Pharmacol · 2023 Over 20 million adults and 6 million children in the United States (US) have asthma, a chronic respiratory disease characterized by airway inflammation, bronchoconstriction, and mucus hypersecretion. Obesity, another highly prevalent disease in the US, is ... Full text Link to item Cite

3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension.

Journal Article Matrix Biol · August 2022 Pulmonary hypertension (PH) comprises a diverse group of disorders that share a common pathway of pulmonary vascular remodeling leading to right ventricular failure. Development of anti-remodeling strategies is an emerging frontier in PH therapeutics that ... Full text Open Access Link to item Cite

Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.

Journal Article Respir Res · May 24, 2022 BACKGROUND: Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that is increased in obesity is leptin. We hypot ... Full text Open Access Link to item Cite

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

Journal Article Lancet Respir Med · December 2021 Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the ... Full text Open Access Link to item Cite

The Gut/Lung Microbiome Axis in Obesity, Asthma, and Bariatric Surgery: A Literature Review.

Journal Article Obesity (Silver Spring) · April 2021 Mounting evidence suggests that obesity, parameters of metabolic syndrome, and asthma are significantly associated. Interestingly, these conditions are also associated with microbiome dysbiosis, notably in the airway microbiome for patients with asthma and ... Full text Open Access Link to item Cite

Dysregulated Metabolism in the Pathophysiology of Non-Allergic Obese Asthma.

Journal Article J Asthma Allergy · 2021 Asthma is an obstructive airway disease that is characterized by reversible airway obstruction and is classically associated with atopic, TH2 driven inflammation. Landmark studies in the second half of the twentieth century identified eosinophils as a key ... Full text Open Access Link to item Cite

Imbalanced Coagulation in the Airway of Type-2 High Asthma with Comorbid Obesity.

Journal Article J Asthma Allergy · 2021 Asthma is a common, chronic airway inflammatory disease marked by airway hyperresponsiveness, inflammation, and remodeling. Asthma incidence has increased rapidly in the past few decades and recent multicenter analyses have revealed several unique asthma e ... Full text Open Access Link to item Cite

Vertical Sleeve Gastrectomy in Chronically Allergen-Challenged Obese Mice Increases Airway Hyperresponsiveness

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Vertical Sleeve Gastrectomy Increased PPAR. Expression in Obese Mice Challenged with House Dust Mite

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Development of a National Academic Boot Camp to Improve Fellowship Readiness.

Journal Article ATS Sch · December 22, 2020 Background: Pulmonary and critical care medicine (PCCM) fellowship requires a high degree of medical knowledge and procedural competency. Gaps in fellowship readiness can result in significant trainee anxiety related to starting fellowship training. Object ... Full text Open Access Link to item Cite

Deficiency in Paraoxonase 2 Increases Airway Hyper Responsiveness After Ozone Exposure in Mice

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Glucagon Like Peptide 1 Attenuates Airway Hyperresponsiveness in a Mouse Model of Obese Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.

Conference J Allergy Clin Immunol · November 2019 Physiological responses to HDM extracts are variable. To increase the transparency and reproducibility of published work, lot numbers, concentration of extract components, and methods for dose normalization need to be thoroughly reported. ... Full text Link to item Cite

Asthma medication usage is significantly reduced following bariatric surgery.

Journal Article Surg Endosc · June 2019 INTRODUCTION: Asthma is an important healthcare problem affecting millions in the United States. Additionally, a large proportion of patients with asthma suffer from obesity. These patients exhibit poor asthma control and reduced therapy response, increasi ... Full text Open Access Link to item Cite

When It Comes to Alternaria, Instant CARMA's Gonna Get You.

Journal Article Am J Respir Cell Mol Biol · December 2018 Full text Open Access Link to item Cite

Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.

Journal Article J Allergy Clin Immunol · March 2018 BACKGROUND: Eosinophils are prominent in some patients with asthma and are increased in the submucosa in a subgroup of obese patients with asthma (OAs). Surfactant protein A (SP-A) modulates host responses to infectious and environmental insults. OBJECTIVE ... Full text Open Access Link to item Cite

Characterization of Paraoxonases in Mice with Obese Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Vertical Sleeve Gastrectomy in Allergen-Challenged Obese Mice Is Associated with Reduced Airway Resistance and Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease.

Journal Article Am J Respir Cell Mol Biol · December 2017 Hyaluronan (HA), a major component of the extracellular matrix, is secreted by airway structural cells. Airway fibroblasts in allergic asthma secrete elevated levels of HA in association with increased HA synthase 2 (HAS2) expression. Thus, we hypothesized ... Full text Open Access Link to item Cite

A novel role for primary cilia in airway remodeling.

Journal Article Am J Physiol Lung Cell Mol Physiol · August 1, 2017 Primary cilia (PC) are solitary cellular organelles that play critical roles in development, homeostasis, and disease pathogenesis by modulating key signaling pathways such as Sonic Hedgehog and calcium flux. The antenna-like shape of PC enables them also ... Full text Open Access Link to item Cite

An in Vitro Model of Airway Fibroblast Functions to Assess Airway Remodeling in Asthma

Conference IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL · August 1, 2017 Link to item Cite

Modeling Human Lung Fibroblast Responses in Asthma and Airway Disease

Conference IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL · June 1, 2017 Link to item Cite

A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma.

Journal Article Am J Respir Cell Mol Biol · March 2017 Limited in vivo models exist to investigate the lung airway epithelial role in repair, regeneration, and pathology of chronic lung diseases. Herein, we introduce a novel animal model in asthma-a xenograft system integrating a differentiating human asthmati ... Full text Open Access Link to item Cite

Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma.

Journal Article Am J Respir Cell Mol Biol · January 2016 Elastin synthesis and degradation in the airway and lung parenchyma contribute to airway mechanics, including airway patency and elastic recoil. IL-13 mediates many features of asthma pathobiology, including airway remodeling, but the effects of IL-13 on e ... Full text Open Access Link to item Cite

Interleukin-17 And Leptin Contribute To Airway Fibrosis And Altered Interleukin-13 Receptor Expression In Obese Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

An In Vivo Model Of Human Airways For Investigating Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

IN VIVO EVIDENCE IN A XENOGRAFT MODEL FOR ASTHMATIC EPITHELIUM DRIVING AIRWAY REMODELING

Journal Article JOURNAL OF INVESTIGATIVE MEDICINE · March 1, 2015 Link to item Cite

Increased Tissue Eosinophilia In Obese Asthma May Be Due To Decreased Surfactant Protein-A Levels

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Leptin Augments Interleukin-13-Induced Eotaxin-1 And Eotaxin-3 Production By Airway Fibroblasts In Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Asthmatic Airway Fibroblasts: Tgf beta Receptor Signaling Is Up-Regulated After Obese Visceral Adipose Exosome Exposure

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

In Vivo Evidence In A Xenograft Model For Asthmatic Epithelium Driving Airway Remodeling

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma.

Journal Article Eur Respir J · February 2014 Airway remodelling is a feature of asthma that contributes to loss of lung function. One of the central components of airway remodelling is subepithelial fibrosis. Interleukin (IL)-13 is a key T-helper 2 cytokine and is believed to be the central mediator ... Full text Open Access Link to item Cite

IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies.

Journal Article J Allergy Clin Immunol · October 2012 Decades of research in animal models have provided abundant evidence to show that IL-13 is a key T(H)2 cytokine that directs many of the important features of airway inflammation and remodeling in patients with allergic asthma. Several promising focused th ... Full text Open Access Link to item Cite

SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells.

Journal Article J Immunol · April 1, 2012 Asthma is a chronic inflammatory disease in which airway epithelial cells are the first line of defense against exposure of the airway to infectious agents. Src homology protein (SHP)-1, a protein tyrosine phosphatase, is a negative regulator of signaling ... Full text Open Access Link to item Cite

Corrigendum

Journal Article American Journal of Physiology-Lung Cellular and Molecular Physiology · February 1, 2012 Full text Cite

Surfactant protein A is defective in abrogating inflammation in asthma.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 2011 Surfactant protein A (SP-A) regulates a variety of immune cell functions. We determined the ability of SP-A derived from normal and asthmatic subjects to modulate the inflammatory response elicited by Mycoplasma pneumoniae, a pathogen known to exacerbate a ... Full text Open Access Link to item Cite

Role of hyaluronan and hyaluronan-binding proteins in human asthma.

Journal Article J Allergy Clin Immunol · August 2011 BACKGROUND: The characteristics of human asthma are chronic inflammation and airway remodeling. Hyaluronan, a major extracellular matrix component, accumulates during inflammatory lung diseases, including asthma. Hyaluronan fragments stimulate macrophages ... Full text Open Access Link to item Cite

Airway fibroblasts in asthma manifest an invasive phenotype.

Journal Article Am J Respir Crit Care Med · June 15, 2011 RATIONALE: Invasive cell phenotypes have been demonstrated in malignant transformation, but not in other diseases, such as asthma. Cellular invasiveness is thought to be mediated by transforming growth factor (TGF)-β1 and matrix metalloproteinases (MMPs). ... Full text Open Access Link to item Cite

IL-13 Induces Procollagen 1 mRNA Expression in Human Airway Fibroblasts in Asthma

Conference Journal of Allergy and Clinical Immunology · February 2010 Full text Cite

MMP Inhibition Attenuates IL-13 Induced Procollagen 1 MRNA Expression In Human Airway Fibroblasts In Asthma

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

Interleukin-13 Induces Airway Fibroblast Invasion In Asthma: Implications For A Mechanism Dependent On MMPs And TGF-beta

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

LL Leptin Modulates The Expression Of Procollagen 1 alpha In Airway Fibroblasts In Asthma

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

Elastin Expression Is Differentially Modulated In The Proximal And Distal Lung Compartments In Asthma

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

Dexamethasone Modulates IL-13 and IL-4 Receptor Subunit Expression in Airway Fibroblasts in Asthma.

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma.

Journal Article Eur Respir J · January 2008 Featured Publication As excess mucin expression can contribute to the exacerbation of asthma, the present authors hypothesised that Mycoplasma pneumoniae significantly induces MUC5AC (the major airway mucin) expression in airway epithelial cells isolated directly from asthmati ... Full text Link to item Cite

Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis.

Journal Article Respir Res · April 25, 2007 Featured Publication BACKGROUND: Exposure to vanadium pentoxide (V2O5) is a cause of occupational bronchitis. We evaluated gene expression profiles in cultured human lung fibroblasts exposed to V2O5 in vitro in order to identify candidate genes that could play a role in inflam ... Full text Link to item Cite

Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.

Journal Article J Immunol · September 15, 2006 Featured Publication IL-13 is a key cytokine involved in airway remodeling in asthma. We previously reported that IL-13 stimulated the mitogenesis of lung fibroblasts via platelet-derived growth factor (PDGF)-AA. In this report, we show that IL-13 increases PDGF-A and PDGF-C m ... Full text Link to item Cite

EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases.

Journal Article Curr Mol Med · June 2006 Featured Publication Cell-surface receptor tyrosine kinases play pivotal roles in development, tissue repair, and normal cellular homeostasis. Aberrant expression or signaling patterns of these kinases has also been linked to the progression of a diversity of diseases, includi ... Full text Link to item Cite

Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis.

Journal Article Am J Pathol · November 2005 The signal transducer and activator of transcription (Stat)-1 mediates growth arrest and apoptosis. We postulated that lung fibrosis characterized by excessive proliferation of lung fibroblasts would be enhanced in Stat1-deficient (Stat1-/-) mice. Two week ... Full text Link to item Cite

IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha.

Journal Article FASEB J · July 2004 Peribronchiolar fibrosis is a prominent feature of airway remodeling in asthma and involves fibroblast growth and collagen deposition. Interleukin-13 (IL-13), a T-helper 2 cytokine, is a key mediator of airway remodeling in asthma, yet the mechanism throug ... Full text Link to item Cite

Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase.

Journal Article Free Radic Biol Med · October 15, 2003 Vanadium compounds present in air pollution particulate matter activate signal transduction pathways in pulmonary cell types leading to pathological outcomes including aberrant cell proliferation, apoptosis, and cytokine expression. Vanadium has been propo ... Full text Link to item Cite

Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 2003 Vanadium pentoxide (V(2)O(5)) is a transition metal derived from the burning of petrochemicals that causes airway fibrosis and remodeling. Vanadium compounds activate many intracellular signaling pathways via the generation of hydrogen peroxide (H(2)O(2)) ... Full text Link to item Cite

p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts.

Journal Article Am J Respir Cell Mol Biol · December 2002 Myofibroblast proliferation is a central feature of pulmonary fibrogenesis. Several growth factors, including platelet-derived growth factor (PDGF) and epidermal growth factor (EGF), stimulate myofibroblast growth by activating extracellular signal regulat ... Full text Link to item Cite

Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.

Journal Article Am J Pathol · August 2002 The cyclooxygenase (COX)-2 enzyme has been implicated as an important mediator of pulmonary fibrosis. In this study, the lung fibrotic responses were investigated in COX-1 or COX-2-deficient (-/-) mice following vanadium pentoxide (V(2)O(5)) exposure. Lung ... Full text Link to item Cite

The role of cell differentiation state and HMG-I/Y in the expression of transgenes flanked by matrix attachment regions.

Journal Article Transgenic Res · October 2001 The tobacco nuclear matrix attachment region (MAR), RB7, has been shown to have a much greater effect on transgene expression in cultured cells than in transgenic plants. This is comparable to work in mouse systems showing that MARs have a positive effect ... Full text Link to item Cite