Scholars@Duke
Jennifer Gloeckner Powers

Jennifer Gloeckner Powers

Adjunct Assistant Professor of Dermatology
Dermatology

Selected Publications

High-frequency ultrasound accuracy in preoperative cutaneous melanoma assessment: A meta-analysis.

Journal Article J Eur Acad Dermatol Venereol · January 2025 BACKGROUND: High-frequency ultrasound (HFUS) can safely and efficiently visualize cutaneous tumour characteristics including depth. OBJECTIVES: We aimed to evaluate its accuracy in measuring melanoma depth against the gold standard, histopathology, for tre ... Full text Link to item Cite

Response—Letter to the Editor: High-frequency ultrasound accuracy in preoperative cutaneous melanoma assessment

Journal Article Journal of the European Academy of Dermatology and Venereology · January 1, 2025 Full text Cite

Recurring Hidradenocarcinoma of the Lower Extremity

Journal Article Journal of the Dermatology Nurses' Association · May 1, 2024 Hidradenocarcinomas are rare adnexal tumor of the sweat glands. They are typically found on the head and neck with a high rate of recurrence and metastasis. Here, we present a case of a 67-year-old woman who presented with long-standing subcutaneous mass o ... Full text Cite

Needle before Scalpel: Considering the Role of Intratumoral Therapy in Melanoma

Journal Article Dermatologic Therapy · January 1, 2024 Advanced melanoma and nonmelanoma skin cancer or cutaneous metastases not amenable to surgery often require alternate therapy. Although surgery is first-line treatment for early-stage melanoma, it can be challenging with multifocal disease, sites with high ... Full text Cite

Managing Surgical Site Scarring as a Complication of Permanent Pacemaker Implantation: A Case Report

Journal Article Journal of the Dermatology Nurses' Association · November 1, 2023 Pathologic collagen deposition in the form of keloid or hypertrophic scarring can result from any procedure that involves skin barrier disturbance. In this case report, we present a case of a patient who developed hypertrophic scarring complicated by the u ... Full text Cite

Targeting the Angiotensin Pathway in the Treatment of Cutaneous Fibrosis: A Systematic Review

Journal Article JID Innovations · November 1, 2023 Acting on the renin–angiotensin–aldosterone system, angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) are mechanisms of some of the most prescribed medications in the world. In addition to their routine use for the ... Full text Cite

Cutaneous Metastasis of Alveolar Rhabdomyosarcoma in a Child.

Journal Article Am J Dermatopathol · March 1, 2023 Rhabdomyosarcoma (RMS) is one of the most common soft tissue sarcomas in children. This lesion is classically included in the generic group of "small round blue cell tumors" along with other entities that share similar microscopic features. Although the he ... Full text Link to item Cite

Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response.

Journal Article J Invest Dermatol · August 2022 The skin serves as the interface between the body and the environment and plays a fundamental role in innate antimicrobial host immunity. Antiviral proteins (AVPs) are part of the innate host defense system and provide protection against viral pathogens. H ... Full text Link to item Cite

Orf Virus in Humans: Case Series and Clinical Review.

Journal Article Cutis · July 2022 Ecthyma contagiosum (orf), a worldwide cause of the hand pustule, is caused by orf virus, a member of the genus Parapoxvirus, which causes an epitheliotropic zoonotic infection that spreads from ruminants (even-toed ungulate mammals such as sheep or goats) ... Full text Link to item Cite

The Genetics of Early-Stage Melanoma in a Veteran Population

Journal Article Frontiers in Oncology · May 30, 2022 To improve understanding of the genetic signature of early-stage melanomas in Veterans, hotspot mutation profiling using next-generation sequencing (NGS) was performed on melanoma tissue samples from patients at the Iowa City Veterans Affairs Medical Cente ... Full text Cite

Visage mauve secondary to chlorpromazine.

Journal Article Ann Clin Psychiatry · February 2022 Full text Link to item Cite

Attenuation of actinic prurigo eruptions with Polypodium leucotomos supplementation.

Journal Article Pediatr Dermatol · January 2022 Actinic prurigo is a rare pruritic photodermatosis. We report the use of Polypodium leucotomos extract in an 11-year-old female patient with actinic prurigo, resulting in a significant attenuation of her disease without development of adverse effects to da ... Full text Link to item Cite

Innovation interest within dermatology: a needs assessment for novel thought processes.

Journal Article Arch Dermatol Res · December 2021 Medical innovation is crucial to advancing our field, and physicians have the potential to play a leading role due to their daily patient care experiences. The objective of this study was to evaluate the interest in, and barriers to participating in innova ... Full text Link to item Cite

Acquired idiopathic generalized anhidrosis: A case series of two Caucasian patients.

Journal Article Pediatr Dermatol · September 2021 Acquired idiopathic generalized anhidrosis (AIGA) is a rare disorder characterized by insidious or sudden onset of the inability to sweat involving >25% of body surface area in the absence of other neurologic or sweat gland abnormalities and typically affe ... Full text Link to item Cite

Metastatic malignant melanoma in an endometrial polyp.

Journal Article Dermatol Online J · April 15, 2021 Melanocytic metastasis to gynecologic organs is rare with most metastases to the ovaries. Metastases to the uterus, or in this case report, a uterine polyp, is exceedingly rare with only 17 cases reported in the literature. Post-menopausal bleeding is the ... Link to item Cite

Postpartum Nipple Symptoms: Risk Factors and Dermatologic Characterization.

Journal Article Breastfeed Med · March 2021 Background: Nipple discomfort inhibits breastfeeding goals, particularly between 0 and 8 weeks postpartum (PP), and yet the specific dermatologic entities that contribute to nipple soreness have not been clearly delineated. Moreover, there remains a lack o ... Full text Link to item Cite

A case of idiopathic acquired leukonychia totalis in a 17-year-old boy.

Journal Article Pediatr Dermatol · March 2021 Whitening of the nail, or leukonychia, can have a wide range of etiologies including genetic disorders, trauma, poisoning, autoimmune disorders, and infections. Here we detail a case of idiopathic acquired leukonychia totalis in a 17-year-old boy. This con ... Full text Link to item Cite

Morphea following treatment with pembrolizumab for melanoma with metastatic lymph nodes: case report and review of literature.

Journal Article Melanoma Res · February 1, 2021 Pembrolizumab is a humanized IgG4 isotype mAb that the targets and blocks the programmed cell death protein 1 receptor on lymphocytes. Its use in treating metastatic melanoma is associated with increased overall survival compared to other older immunothera ... Full text Link to item Cite

Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank.

Journal Article J Am Med Inform Assoc · January 15, 2021 The ability to analyze human specimens is the pillar of modern-day translational research. To enhance the research availability of relevant clinical specimens, we developed the Living BioBank (LBB) solution, which allows for just-in-time capture and delive ... Full text Link to item Cite

Emerging Priorities for Microbiome Research

Journal Article Frontiers in Microbiology · February 19, 2020 Microbiome research has increased dramatically in recent years, driven by advances in technology and significant reductions in the cost of analysis. Such research has unlocked a wealth of data, which has yielded tremendous insight into the nature of the mi ... Full text Cite

Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials.

Journal Article Cancer · January 1, 2019 Recent progress in the treatment of advanced melanoma has led to unprecedented improvements in overall survival and, as these new melanoma treatments have been developed and deployed in the clinic, much has been learned about the natural history of the dis ... Full text Link to item Cite

Use of Stem Cells in Wound Healing

Journal Article Current Dermatology Reports · December 1, 2018 Purpose of Review: This review provides an overview of the principal stages of wound healing, the populations of endogenous and therapeutic stem cells, applications of stem cells in specific types of wounds, and current approaches of stem cell delivery for ... Full text Cite

Skin cancer in the military: A systematic review of melanoma and nonmelanoma skin cancer incidence, prevention, and screening among active duty and veteran personnel.

Journal Article J Am Acad Dermatol · June 2018 BACKGROUND: Occupational sun exposure is a well-studied risk factor for skin cancer development, but more work is needed to assess melanoma and nonmelanoma skin cancer risk among US military personnel to improve education and screening efforts in this popu ... Full text Link to item Cite

Drug-induced linear IgA bullous dermatosis in a patient with a vancomycin-impregnated cement spacer.

Journal Article Cutis · April 2018 Linear IgA bullous dermatosis (LABD) is an autoimmune blistering rash caused by IgA autoantibodies against the epidermal basement membrane zone. It commonly is drug induced, often in association with systemic vancomycin. We report a case of a previously he ... Link to item Cite

Characterization of blue light irradiation effects on pathogenic and nonpathogenic Escherichia coli.

Journal Article Microbiologyopen · August 2017 Blue light irradiation (BLI) is an FDA-approved method for treating certain types of infections, like acne, and is becoming increasingly attractive as an antimicrobial strategy as the prevalence of antibiotic-resistant "superbugs" rises. However, no study ... Full text Link to item Cite

Resistance to narrowband ultraviolet B therapy over varicose veins in two cases of generalized vitiligo

Journal Article Journal of the Dermatology Nurses' Association · June 1, 2017 Vitiligo is a difficult-to-control disease with a devastating impact in the lives of many patients. An association has been shown between the Koebner phenomenon and the occurrence of skin depigmentation in vitiligo. However, the medical literature contains ... Full text Cite

Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment.

Journal Article J Am Acad Dermatol · May 2016 Both inherited and acquired hypercoagulable states can present with nonspecific clinical manifestations, such as petechiae, purpura, livedo reticularis, and ulcerations. A good history and physical examination are crucial to diagnoses of these conditions. ... Full text Link to item Cite

Coagulation disorders and their cutaneous presentations: Pathophysiology.

Journal Article J Am Acad Dermatol · May 2016 Hypercoagulable states are inherited or acquired predispositions to venous or arterial thromboses that are best understood in the context of the coagulation cascade. Dermatologists can play a critical role in diagnosing and treating patients with hypercoag ... Full text Link to item Cite

Wound healing and treating wounds: Chronic wound care and management.

Journal Article J Am Acad Dermatol · April 2016 In the United States, chronic ulcers--including decubitus, vascular, inflammatory, and rheumatologic subtypes--affect >6 million people, with increasing numbers anticipated in our growing elderly and diabetic populations. These wounds cause significant mor ... Full text Link to item Cite

A painful pigmented nodule in a patient with metastatic melanoma

Journal Article Journal of Cutaneous Pathology · December 1, 2015 Full text Cite

The Skin Cancer Objective Structured Clinical Examination (SCOSCE): A multi-institutional collaboration to develop and validate a clinical skills assessment for melanoma.

Journal Article J Am Acad Dermatol · December 2015 BACKGROUND: Assessing medical students on core skills related to melanoma detection is challenging in the absence of a well-developed instrument. OBJECTIVE: We sought to develop an objective structured clinical examination for the detection and evaluation ... Full text Link to item Cite

Cutaneous collagenous vasculopathy

Journal Article Journal of Clinical and Aesthetic Dermatology · November 1, 2015 Cutaneous collagenous vasculopathy is a rare microangiopathy of dermal blood vessels. Clinically indistinguishable from generalized essential telangiectasia, this condition is diagnosed by its unique histological appearance. In contrast to other primary te ... Cite

Erythematous plaques on the knee

Journal Article Journal of the Dermatology Nurses' Association · January 1, 2015 This is a case of erythematous plaques on the knees of a 14-month-old infant. Readerswill be challenged to identify different diagnoses based on case presentation, history, and symptoms. Erythematous plaques on the extremities in infants require careful as ... Full text Cite

Linear, pruritic red to brown papules on the left chest.

Journal Article Dermatol Online J · November 15, 2014 A 28-year-old woman presented with a 12-year history of red to brown papules in a linear distribution on the left lateral chest associated with recent flares of pruritus. She had previously been clinically diagnosed with lichen planus. A punch biopsy was p ... Link to item Cite

Effective blue light photodynamic therapy does not affect cutaneous langerhans cell number or oxidatively damage DNA.

Journal Article Dermatol Surg · September 2014 BACKGROUND: Photodynamic therapy (PDT) using aminolevulinic acid (ALA) with blue light or red light is effective for treating actinic keratoses (AKs). However, immunosuppression follows red light PDT, raising the spectre of skin cancer promotion in treated ... Full text Link to item Cite

Curricular factors associated with medical students' practice of the skin cancer examination: an educational enhancement initiative by the integrated skin exam consortium.

Journal Article JAMA Dermatol · August 2014 IMPORTANCE: As medical school curricula become progressively integrated, a need exists to optimize education related to the skin cancer examination (SCE) for melanoma, a relevant competency gap that influences secondary prevention efforts. OBJECTIVES: To i ... Full text Link to item Cite

The integrated skin exam film: An educational intervention to promote early detection of melanoma by medical students

Journal Article Journal of the American Academy of Dermatology · January 1, 2014 Background Knowledge of the skin cancer examination (SCE) and its practice remain relevant competency gaps among medical students. Objective We elaborate on a method of SCE known as the Integrated Skin Exam and discuss the development of an instructional f ... Full text Cite

Wound dressings: selecting the most appropriate type.

Journal Article Am J Clin Dermatol · December 2013 Appropriate wound dressing selection is guided by an understanding of wound dressing properties and an ability to match the level of drainage and depth of a wound. Wounds should be assessed for necrosis and infection, which need to be addressed prior to se ... Full text Link to item Cite

Severe cutaneous and neurologic toxicity in melanoma patients during vemurafenib administration following anti-PD-1 therapy.

Journal Article Cancer Immunol Res · December 2013 Immune checkpoint inhibitors such as ipilimumab and targeted BRAF inhibitors have dramatically altered the landscape of melanoma therapeutics over the past few years. Agents targeting the programmed cell death-1/ligand (PD-1/PD-L1) axis are now being devel ... Full text Link to item Cite

Dressings for chronic wounds.

Journal Article Dermatol Ther · 2013 Covering wounds, acute and chronic, is one of the most fundamental activities of any medical practitioner. Although wound dressings primarily serve to contain the "good" and keep out the "bad," research has characterized more specifically the sophisticated ... Full text Link to item Cite

Right-sided vascular lesions: answer.

Journal Article Am J Dermatopathol · December 2012 Full text Link to item Cite

Right-sided vascular lesions: challenge.

Journal Article Am J Dermatopathol · December 2012 Full text Link to item Cite

Fatal Henoch-Schonlein purpura in an adult related to bowel perforation: report and review of the literature.

Journal Article Dermatol Online J · October 15, 2012 BACKGROUND: Henoch-Schonlein purpura is an idiopathic, IgA associated, systemic small-vessel vasculitis characterized by the clinical tetrad of palpable purpura, arthralgias, renal dysfunction, and abdominal pain. Whereas Henoch-Schonlein is an overwhelmin ... Link to item Cite

What is your diagnosis? Spitzoid melanoma.

Journal Article Cutis · October 2012 Link to item Cite

Levamisole-induced vasculopathy: a report of 2 cases and a novel histopathologic finding.

Journal Article Am J Dermatopathol · April 2012 Although cocaine-induced pseudovasculitis and urticarial vasculitis have been reported in the past, levamisole-induced vasculopathy with ecchymosis and necrosis, termed here LIVEN, has only recently been described in association with cocaine use. Levamisol ... Full text Link to item Cite

What you and your patients need to know about vitamin D.

Journal Article Semin Cutan Med Surg · March 2012 "Vitamin D" is the term commonly used to denote the lipid-soluble hormone critical for calcium homeostasis and skeletal maintenance. A precursor to the active compound is found in many plants and animal tissues and can be absorbed from the gut; it can also ... Full text Link to item Cite

Right-sided vascular lesions: answer.

Journal Article The American Journal of dermatopathology · January 1, 2012 Cite

Slowly growing, ulcerating nodule on the posterior ankle

Journal Article Wounds · October 1, 2011 A 34-year-old Haitian man presented with a 1-year history of a gradually en-larging, ulcerating nodule on the right posterior ankle that bled after trauma. The patient denied any history of prior trauma at the site of the lesion and foreign travel.There we ... Cite