Scholars@Duke
Jianping Xia

Selected Publications

Acoustic separation and isolation of viruses, small extracellular vesicles and other nanoscale bioparticles.

Journal Article Nature protocols · January 2026 The isolation of small extracellular vesicles (sEVs), viruses and other nanoscale lipid particles from biofluids offers actionable possibilities for advancing disease diagnosis, drug delivery, regenerative medicine, personalized medicine and immunotherapy. ... Full text Cite

Programmable acoustofluidic engineering for creating gradient biomaterials.

Journal Article Science advances · December 2025 Gradient biomaterials that exhibit spatially varying physical, chemical, or biological properties can be used in various applications such as tissue engineering, organoid development, mechanobiology, and spatially controlled drug delivery. However, current ... Full text Cite

Enhancing cancer therapy <i>via</i> acoustics: chemotherapy-enhanced tunable acoustofluidic permeabilization (ChemoTAP).

Journal Article Lab on a chip · November 2025 Mechano-chemo cancer treatment is an emerging therapeutic strategy that enhances chemotherapy efficacy by combining chemical agents with mechanical forces to improve drug uptake and overcome resistance. However, current approaches for delivering mechanical ... Full text Cite

Acoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis.

Journal Article Sci Adv · September 5, 2025 Antibody-mediated rejection is a leading cause of allograft failure and mortality in pediatric solid organ transplant recipients. Current apheresis systems require large blood volumes and are primarily designed for adults, making them unsuitable for childr ... Full text Link to item Cite

Nanoscale acoustic oscillator for mechanoimmunology: NAOMI.

Journal Article Science advances · August 2025 Mechanoimmunology explores how mechanical forces orchestrate immune responses, offering insights into immune cell functions and the mechanisms underlying mechanotransduction. A critical challenge in this field is the absence of reliable platforms that appl ... Full text Cite

Acoustic technologies for the orchestration of cellular functions for therapeutic applications.

Journal Article Science advances · July 2025 Mechanical forces constantly stimulate cellular functions and influence their response behaviors. Similar to how an orchestra's music synchronizes an audience, acoustic technologies have emerged as precise, contact-free tools to study cellular responses. T ... Full text Cite

A multi-platform assessment of extracellular vesicles from the plasma and urine of women with preeclampsia.

Journal Article Placenta · June 2025 IntroductionMicroRNAs (miRNAs), packaged within extracellular vesicles (EVs), have been used to interrogate the pathogenesis of preeclampsia and to identify its biomarkers. We have previously shown that miRNA species were differentially expressed ... Full text Cite

Topological acoustofluidics.

Journal Article Nature materials · May 2025 The complex interaction of spin, valley and lattice degrees of freedom allows natural materials to create exotic topological phenomena. The interplay between topological wave materials and hydrodynamics could offer promising opportunities for visualizing t ... Full text Cite

Recent progress on acoustofluidic manipulation of cells and particles

Journal Article National Science Open · March 1, 2025 Full text Cite

Rapid and comprehensive detection of viral antibodies and nucleic acids via an acoustofluidic integrated molecular diagnostics chip: AIMDx.

Journal Article Science advances · January 2025 Precise and rapid disease detection is critical for controlling infectious diseases like COVID-19. Current technologies struggle to simultaneously identify viral RNAs and host immune antibodies due to limited integration of sample preparation and detection ... Full text Open Access Cite

An Acoustofluidic Device for Sample Preparation and Detection of Small Extracellular Vesicles.

Journal Article Cyborg and bionic systems (Washington, D.C.) · January 2025 Small extracellular vesicles (sEVs) have emerged as powerful vectors for liquid biopsy, offering a noninvasive window into the dynamic physiological and pathological states of the body. However, to fully leverage the clinical potential of sEV biomarkers, i ... Full text Cite

Acoustofluidic tweezers via ring resonance.

Journal Article Science advances · November 2024 Ring resonator (RR) devices are closed-loop waveguides where waves circulate only at the resonant frequencies. They have been used in sensor technology and optical tweezers, but controlling micron-scale particles with optical RR tweezers is challenging due ... Full text Cite

Sound innovations for biofabrication and tissue engineering.

Journal Article Microsystems & nanoengineering · November 2024 Advanced biofabrication techniques can create tissue-like constructs that can be applied for reconstructive surgery or as in vitro three-dimensional (3D) models for disease modeling and drug screening. While various biofabrication techniques have recently ... Full text Cite

Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation.

Journal Article Nature communications · October 2024 Contactless microscale tweezers are highly effective tools for manipulating, patterning, and assembling bioparticles. However, current tweezers are limited in their ability to comprehensively manipulate bioparticles, providing only partial control over the ... Full text Cite

Acoustofluidic-based therapeutic apheresis system.

Journal Article Nat Commun · August 10, 2024 Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the tes ... Full text Open Access Link to item Cite

Acousto-dielectric tweezers enable independent manipulation of multiple particles.

Journal Article Science advances · August 2024 Acoustic tweezers have gained substantial interest in biology, engineering, and materials science for their label-free, precise, contactless, and programmable manipulation of small objects. However, acoustic tweezers cannot independently manipulate multipl ... Full text Cite

Acoustofluidic Virus Isolation via Bessel Beam Excitation Separation Technology.

Journal Article ACS nano · August 2024 The isolation of viruses from complex biological samples is essential for creating sensitive bioassays that assess the efficacy and safety of viral therapeutics and vaccines, which have played a critical role during the COVID-19 pandemic. However, existing ... Full text Cite

Acoustic separation and concentration of exosomes for nucleotide detection: ASCENDx.

Journal Article Sci Adv · March 8, 2024 Efficient isolation and analysis of exosomal biomarkers hold transformative potential in biomedical applications. However, current methods are prone to contamination and require costly consumables, expensive equipment, and skilled personnel. Here, we intro ... Full text Link to item Cite

Aerosol jet printing of surface acoustic wave microfluidic devices.

Journal Article Microsystems & nanoengineering · January 2024 The addition of surface acoustic wave (SAW) technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes, including high-precision manipulation, versatility, integrability, biocompatibility, cont ... Full text Cite

High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping: FLOAT.

Journal Article Microsystems & nanoengineering · January 2024 Extracellular vesicles (EVs) have been identified as promising biomarkers for the noninvasive diagnosis of various diseases. However, challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low purities. Here, we ... Full text Cite

Acoustofluidic scanning fluorescence nanoscopy with a large field of view.

Journal Article Microsystems & nanoengineering · January 2024 Large-field nanoscale fluorescence imaging is invaluable for many applications, such as imaging subcellular structures, visualizing protein interactions, and high-resolution tissue imaging. Unfortunately, conventional fluorescence microscopy requires a tra ... Full text Cite

An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood.

Journal Article Microsyst Nanoeng · 2024 Separating plasma from whole blood is an important sample processing technique required for fundamental biomedical research, medical diagnostics, and therapeutic applications. Traditional protocols for plasma isolation require multiple centrifugation steps ... Full text Open Access Link to item Cite

Cellular immunity analysis by a modular acoustofluidic platform: CIAMAP.

Journal Article Science advances · December 2023 The study of molecular mechanisms at the single-cell level holds immense potential for enhancing immunotherapy and understanding neuroinflammation and neurodegenerative diseases by identifying previously concealed pathways within a diverse range of paired ... Full text Cite

Acoustofluidic Interfaces for the Mechanobiological Secretome of MSCs.

Journal Article Nature communications · November 2023 While mesenchymal stem cells (MSCs) have gained enormous attention due to their unique properties of self-renewal, colony formation, and differentiation potential, the MSC secretome has become attractive due to its roles in immunomodulation, anti-inflammat ... Full text Cite

Programmable dual-band acoustic topological insulator with dynamically movable interface states

Journal Article Applied Physics Reviews · September 1, 2023 Topological acoustic interface states in one-dimensional (1D) acoustic topological insulators (ATIs) are zero-dimensional (0D) topological states localized at an interface. Unlike topological edge states that can propagate to deliver information in acousti ... Full text Cite

A solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER).

Journal Article Science advances · November 2022 High-precision isolation of small extracellular vesicles (sEVs) from biofluids is essential toward developing next-generation liquid biopsies and regenerative therapies. However, current methods of sEV separation require specialized equipment and time-cons ... Full text Cite

Intelligent nanoscope for rapid nanomaterial identification and classification.

Journal Article Lab on a chip · August 2022 Machine learning image recognition and classification of particles and materials is a rapidly expanding field. However, nanomaterial identification and classification are dependent on the image resolution, the image field of view, and the processing time. ... Full text Cite

Acoustofluidic multimodal diagnostic system for Alzheimer's disease.

Journal Article Biosens Bioelectron · January 15, 2022 Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative brain disorder that affects tens of millions of older adults worldwide and has significant economic and societal impacts. Despite its prevalence and severity, early diagnosis of A ... Full text Link to item Cite

An acoustofluidic scanning nanoscope using enhanced image stacking and processing.

Journal Article Microsystems & nanoengineering · January 2022 Nanoscale optical resolution with a large field of view is a critical feature for many research and industry areas, such as semiconductor fabrication, biomedical imaging, and nanoscale material identification. Several scanning microscopes have been develop ... Full text Cite

Acoustofluidic Droplet Sorter Based on Single Phase Focused Transducers.

Journal Article Small (Weinheim an der Bergstrasse, Germany) · November 2021 Droplet microfluidics has revolutionized the biomedical and drug development fields by allowing for independent microenvironments to conduct drug screening at the single cell level. However, current microfluidic sorting devices suffer from drawbacks such a ... Full text Cite

Acoustic Bessel Vortex Beam by Quasi-Three-Dimensional Reflected Metasurfaces.

Journal Article Micromachines · November 2021 Vortex beams have a typical characteristic of orbital angular momentum, which provides a new degree of freedom for information processing in remote communication and a form of non-contact manipulation for trapping particles. In acoustics, vortex beams are ... Full text Cite

Acoustoelectronic nanotweezers enable dynamic and large-scale control of nanomaterials.

Journal Article Nature communications · June 2021 The ability to precisely manipulate nano-objects on a large scale can enable the fabrication of materials and devices with tunable optical, electromagnetic, and mechanical properties. However, the dynamic, parallel manipulation of nanoscale colloids and ma ... Full text Cite

Acoustohydrodynamic tweezers via spatial arrangement of streaming vortices.

Journal Article Science advances · January 2021 Acoustics-based tweezers provide a unique toolset for contactless, label-free, and precise manipulation of bioparticles and bioanalytes. Most acoustic tweezers rely on acoustic radiation forces; however, the accompanying acoustic streaming often generates ... Full text Cite

Deterministic droplet coding via acoustofluidics.

Journal Article Lab on a chip · November 2020 Droplet microfluidics has become an indispensable tool for biomedical research and lab-on-a-chip applications owing to its unprecedented throughput, precision, and cost-effectiveness. Although droplets can be generated and screened in a high-throughput man ... Full text Cite

Broadband integrative acoustic asymmetric focusing lens based on mode-conversion meta-atoms

Journal Article Applied Physics Letters · June 1, 2020 Acoustic asymmetric focusing (AAF) has a great potential application in medical ultrasound imaging, focused ultrasound therapy, and nondestructive testing. The advancement of acoustic metamaterials and metasurfaces has provided various mechanisms t ... Full text Cite

A disposable acoustofluidic chip for nano/microparticle separation using unidirectional acoustic transducers.

Journal Article Lab on a chip · April 2020 Separation of nano/microparticles based on surface acoustic waves (SAWs) has shown great promise for biological, chemical, and medical applications ranging from sample purification to cancer diagnosis. However, the permanent bonding of a microchannel onto ... Full text Cite

Observation of a topological nodal surface and its surface-state arcs in an artificial acoustic crystal.

Journal Article Nature communications · November 2019 Three-dimensional (3D) gapless topological phases can be classified by the dimensionality of the band degeneracies, including zero-dimensional (0D) nodal points, one-dimensional (1D) nodal lines, and two-dimensional (2D) nodal surfaces. Both nodal points a ... Full text Cite

Dual-Band Fano Resonance of Low-Frequency Sound Based on Artificial Mie Resonances.

Journal Article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · October 2019 It is reported both experimentally and numerically that dual-band acoustic Fano resonances (AFRs) of low-frequency sound are realized by a compound unit array composed of two types of multiple-cavity unit cells with different inner radii. Eigenmode analyse ... Full text Cite

Multifunctional asymmetric sound manipulations by a passive phased array prism

Journal Article Physical Review Applied · August 16, 2019 We report the theoretical and experimental realization of four types of passive phased array prisms with various asymmetric acoustic manipulations (AAMs) in air. The designed prisms consist of 31 transmitted unit cells of phase manipulation, which are comp ... Full text Cite

Topological triply degenerate point with double Fermi arcs

Journal Article Nature Physics · July 1, 2019 Unconventional chiral particles have recently been predicted to appear in certain three-dimensional crystal structures containing three- or more-fold linear band degeneracy points (BDPs)1–4. These BDPs carry topological charges, but are distinct ... Full text Cite

Binary-phase acoustic passive logic gates.

Journal Article Scientific reports · June 2019 The recent rapid development of acoustic logic devices has opened up the possibilities of sound computing and information processing. However, simultaneous realization of acoustic logic devices with subwavelength size, broad bandwidth and passive structure ... Full text Cite

Acoustic energy harvesting for low-frequency airborne sound based on compound Mie resonances

Journal Article Applied Physics Express · April 1, 2019 We report the realization of acoustic energy harvesting for low-frequency sound in a subwavelength system consisting of eight multiple-cavity units. This exotic energy harvesting phenomenon arises from a compound monopole Mie resonance (MMR) induced by mut ... Full text Cite

Programmable Coding Acoustic Topological Insulator.

Journal Article Advanced materials (Deerfield Beach, Fla.) · November 2018 Topological acoustics has recently revolutionized fundamental concepts of acoustic propagation, giving rise to strikingly unique acoustic edge modes immune to backscattering. Despite the rapid progress in this field, simultaneous realization of reconfigura ... Full text Cite

Acoustic topological insulator by honeycomb sonic crystals with direct and indirect band gaps

Journal Article New Journal of Physics · September 1, 2018 We report both experimentally and numerically that a flow-free pseudospin-dependent acoustic topological insulator (ATI) is realized by two honeycomb sonic crystals with direct and indirect band gaps. By simply rotating triangular rods of the sonic crystal ... Full text Cite

Broadband Tunable Acoustic Asymmetric Focusing Lens from Dual-Layer Metasurfaces

Journal Article Physical Review Applied · July 17, 2018 We report both experimentally and numerically that a broadband acoustic lens with asymmetric focusing is realized by dual-layer metasurfaces in air. The acoustic waves can be focused on a side with 0.4 wavelength resolution focusing characteristic, but can ... Full text Cite

Broadband acoustic focusing by cavity structures with phase manipulations

Journal Article Journal of Applied Physics · December 28, 2017 We numerically and experimentally realize broadband acoustic focusing lenses by employing units of phase manipulation composed of different numbers of cavity structures immersed in air, which is different from other units of phase manipulation by adjusting ... Full text Cite

Broadband acoustic logic gates in a circular waveguide with multiple ports

Journal Article Applied Physics Letters · December 11, 2017 We report both experimentally and numerically that a broadband acoustic logic gate is realized by multi-port circular waveguides immersed in air. The logic functions OR, NOT, AND, XOR, and XNOR are realized by the three-port and four-port circular waveguid ... Full text Cite

Thermoacoustic focusing lens by symmetric Airy beams with phase manipulations

Journal Article Journal of Physics D Applied Physics · November 21, 2017 We report the realization of broadband acoustic focusing lenses based on two symmetric thermoacoustic phased arrays of Airy beams, in which the units of thermoacoustic phase control are designed by employing air with different temperatures surrounded by ri ... Full text Cite

Asymmetric acoustic convergence in a metal plate with binary wave-path slits

Journal Article Journal of Physics D Applied Physics · August 10, 2017 We report both experimentally and numerically that asymmetric acoustic convergence is realized by perforating two types of slits (inclined and vertical slits) in a steel plate immersed in water. The asymmetric acoustic convergence phenomenon exists in the ... Full text Cite

Acoustic focusing by thermoacoustic phased array

Journal Article Wuli Xuebao Acta Physica Sinica · August 5, 2017 Broadband acoustic focusing effect based on a thermoacoustic phased array is studied. In this work, according to the relationship between the sound velocity and the temperature, a new type of a thermoacoustic phase control unit is designed by using air wit ... Full text Cite

Modulating Sound with Acoustic Metafiber Bundles.

Journal Article Scientific reports · August 2017 Acoustic metamaterials and metasurfaces provide great flexibility for manipulating sound waves and promise unprecedented functionality, ranging from transformation acoustics, acoustic cloaking, acoustic imaging to acoustic rerouting. However, the design of ... Full text Cite

Asymmetric acoustic transmission in an open channel based on multiple scattering mechanism

Journal Article Applied Physics A Materials Science and Processing · May 1, 2017 We report both experimentally and theoretically that asymmetric acoustic transmission is realized by an open channel with two triangle cavities of different sizes on each side immersed in air. This exotic phenomenon stems from asymmetric multiple scatterin ... Full text Cite

Broadband asymmetric acoustic transmission in a single medium by an array of heat sources

Journal Article Journal of Physics D Applied Physics · March 16, 2017 We report the realization of a broadband asymmetric acoustic transmission with six different-temperature heat sources in air. This exotic effect arises from the desired refractive index in propagation paths induced from heat sources of different temperatur ... Full text Cite

Propagation characteristics of laser-generated surface acoustic waves in composite plate with gradient changes of near-surface viscous moduli

Journal Article Wuli Xuebao Acta Physica Sinica · November 20, 2016 Taking into account the gradient change of the near-surface viscous property, we develop a finite element model of laser-generated surface acoustic wave in composite plate. The propagation characteristics of the surface acoustic wave in the composite plate ... Full text Cite

Acoustic focusing through two layer annuluses in air

Journal Article Chinese Physics B · October 1, 2016 We report an acoustic focusing lens composed of two-layer annuluses made of metal cylinders in air. We find that the cylindrical waves can be focused into a perfect point without diffraction in the centre of the annuluses, which arises from the Mie-resonan ... Full text Cite

Extraordinary acoustic transmission through annuluses in air and its applications in acoustic beam splitter and concentrator.

Journal Article The Review of scientific instruments · August 2016 We report an extraordinary acoustic transmission through two layer annuluses made of metal cylinders in air both numerically and experimentally. The effect arises from the enhancement and reconstruction of the incident source induced by different Mie-reson ... Full text Cite

Multi-band asymmetric acoustic transmission in a bended waveguide with multiple mechanisms

Journal Article Applied Physics Letters · July 4, 2016 We report the realization of a multi-band device of the asymmetric acoustic transmission by placing a phononic crystal inside a bended waveguide immersed in water, as determined both experimentally and numerically. The asymmetric acoustic transmission exis ... Full text Cite

Acoustic focusing by an array of heat sources in air

Journal Article Applied Physics Express · June 1, 2016 We report on a broadband acoustic focusing lens comprising 20 heat sources of different temperatures, 10 on each side of the array, in air. This focusing phenomenon is attributed to temperature gradients inducing the desired refractive index in one medium ... Full text Cite

Theoretical and experimental verification of acoustic focusing in metal cylinder structure

Journal Article Applied Physics Express · May 1, 2016 We report the realization of a multifocal acoustic focusing lens using a simple metal cylinder structure immersed in water, as determined both experimentally and theoretically. The acoustic waves can be focused on one or more points, because the Mie-resona ... Full text Cite

Experimental verification of manipulating propagation directions of transmitted waves in asymmetric acoustic transmission

Journal Article Applied Physics A Materials Science and Processing · April 1, 2016 The manipulation of the propagation directions of the transmitted waves in an acoustic system with asymmetric acoustic transmission is investigated numerically and experimentally, in which the system consists of a brass plate and a periodical grating immer ... Full text Cite

Broadband acoustic focusing effect based on temperature gradient distribution

Journal Article Wuli Xuebao Acta Physica Sinica · February 20, 2016 Acoustic focusing effect with broad bandwidth based on the temperature gradient distribution is studied. The propagation paths of the acoustic waves can be controlled by the temperature gradient distribution generated by two heat sources, which is adopted ... Full text Cite

Propagation Characteristics of Laser-Generated Rayleigh Waves in Coating-Substrate Structures with Anisotropic and Viscoelastic Properties

Conference International Journal of Thermophysics · November 16, 2015 The propagation characteristics of laser-generated Rayleigh waves in coating-substrate structures with anisotropic and viscoelastic properties have been investigated quantitatively. Based on the plane strain theory, finite element models for simulating las ... Full text Cite

Extraordinary acoustic transmission based on source pattern enhancement and reconstruction by metal cylinder structure

Journal Article Applied Physics Express · October 1, 2015 We report extraordinary acoustic transmission through a simple metal cylinder structure immersed in water. This exotic phenomenon stems from the enhancement and reconstruction of the incident source induced by the cylinder, which is essentially distinct fr ... Full text Cite

Acoustic focusing by metal circular ring structure

Journal Article Applied Physics Letters · February 9, 2015 We report an exotic acoustic focusing effect through a simple brass circular ring structure immersed in water. The acoustic waves can be focused on a prefect point at the centre of the ring structure. This exotic acoustic focusing phenomenon arises from th ... Full text Cite