Skip to main content

Jiaoti Huang

Johnston-West Distinguished Professor of Pathology
Pathology

Selected Grants


2/3 CTSA K12 Program at Duke University

ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030

Targeting Undruggable Transcription Factor HoxB13 to Inhibit Prostate Cancer Metastasis

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2025 - 2029

Understanding and targeting epigentic regulation of immune evasion in prostate cancer

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2029

Testing ATAD2 as a new therapeutic target for advanced prostate cancer

ResearchPrincipal Investigator · Awarded by University of California - Los Angeles · 2024 - 2029

Elucidating alternative polyadenylation regulation during prostate cancer progression to castration-resistance

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2029

NEUROD1 function in SCLC fate and plasticity

ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029

Assessment of the Optimal Settings of TFL for Laser Lithotripsy and Associated Thermal Injury Risk

ResearchCo Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2025 - 2028

The Duke Preparing Research scholars In bioMEdical sciences (PRIME): Cancer Research Program

ResearchPreceptor · Awarded by National Cancer Institute · 2023 - 2028

Targeting MED31-driven transcription recycling in lethal prostate cancer

ResearchCo Investigator · Awarded by National Cancer Institute · 2023 - 2028

The role of focal adhesion kinase in therapy resistant prostate tumors

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2023 - 2028

NUAK2 as a novel splicing regulatory kinase in Neuroendocrine Prostate Cancer

ResearchCo-Mentor · Awarded by Department of Defense · 2025 - 2027

Developing A Novel Combinatorial Therapy for Lethal Neuroendocrine Prostate Cancer

ResearchCo Investigator · Awarded by National Cancer Institute · 2022 - 2027

Targeting Ferroptosis in Lethal RB1 Deficient Prostate Cancer

ResearchCo Investigator · Awarded by National Cancer Institute · 2022 - 2027

Engineering Large Chromosomal Deletions in Mice to Advance Precision Oncology for Prostate Cancer

ResearchCo Investigator · Awarded by National Cancer Institute · 2022 - 2027

Interrupting the aberrant cancer development sequence in epithelial cancer progression

ResearchMentor · Awarded by Prostate Cancer Foundation · 2021 - 2027

ASXL2/MLL3/MLL4 complexes in prostate cancer therapy

ResearchCo Investigator · Awarded by Mike Slive Foundation · 2026 - 2026

Glutaminase I isoforms as personalized biomarkers of prostate cancer

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2022 - 2026

Targeting neuroendocrine cells in prostate cancer with small molecule and targeted radionuclide therapies

ResearchCo-Principal Investigator · Awarded by Prostate Cancer Foundation · 2023 - 2026

Targeting NUAK2 in neuroendocrine prostate cancer

ResearchCo Investigator · Awarded by Department of Defense · 2023 - 2026

Defining Cellular and Genetic Factors for Renal Cell Carcinoma Subtypes

ResearchCollaborator · Awarded by Department of Defense · 2022 - 2026

Murine modeling and immunotherapeutic targeting of GPC3 positive prostate cancer

ResearchCollaborating Investigator · Awarded by Mike Slive Foundation · 2025 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026

Blocking glutamine utilization in advanced and therapy-resistant prostate cancer

ResearchCo-Mentor · Awarded by Department of Defense · 2024 - 2026

Delineate the role of GSTP1 in Aggressive Prostate Cancer

ResearchPrincipal Investigator · Awarded by University of California - Los Angeles · 2023 - 2026

Exploitation of a new targetable node in the AR signaling pathway in prostate cancer

ResearchCollaborator · Awarded by Department of Defense · 2022 - 2025

Targeting oncogenomic function of N-Myc to inhibit neuroendocrine prostate cancer visceral metastasis

ResearchCo Investigator · Awarded by Department of Defense · 2023 - 2025

Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer

ResearchCollaborator · Awarded by National Institutes of Health · 2019 - 2025

Role of JMJD1A modifications in castration resistance of prostate cancer

ResearchCo Investigator · Awarded by University of Maryland, Baltimore · 2022 - 2025

PRMT5/MEP50 as a critical epigenetic regulator and therapeutic target for therapy-induced neuroendocrine prostate cancer

ResearchPrincipal Investigator · Awarded by Purdue University · 2022 - 2025

Preclinical studies of DRP-104 in targeting glutamine metabolism of prostate cancer

ResearchPrincipal Investigator · Awarded by Dracen Pharmaceuticals · 2022 - 2025

Targeting NUAK2 to mitigate obesity-enhanced prostate cancer growth and metastasis

ResearchCo Investigator · Awarded by Department of Defense · 2021 - 2024

Transcriptional reprogramming of lethal small cell prostate cancer

ResearchCollaborator · Awarded by Department of Defense · 2021 - 2024

Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

A novel mitotic regulatory axis in neuroendocrine prostate cancer

ResearchPrincipal Investigator · Awarded by University of Pittsburgh · 2019 - 2024

Targeting neuroendocrine prostate cancer by engineering 3' untranslated regions

ResearchCo Investigator · Awarded by Department of Defense · 2020 - 2024

Confirmation of histologic SCNC (NEPC)

ResearchPrincipal Investigator · Awarded by BioXcel Therapeutics · 2019 - 2024

Targeting glutamine utilization in therapy-resistant prostate cancer

ResearchMentor · Awarded by Department of Defense · 2021 - 2024

Targeting RNA splicing in race-related aggressive and lethal prostate cancer

Clinical TrialCo Investigator · Awarded by Prostate Cancer Foundation · 2018 - 2023

Role and targeting of PRMT5 in prostate cancer

ResearchPrincipal Investigator · Awarded by Purdue University · 2017 - 2023

Targeting Glutaminase Isoforms for Therapy-Resistant Prostate Cancer

ResearchPrincipal Investigator · Awarded by Department of Defense · 2019 - 2022

Defining the Essential Determinants of Prostate Cancer Differentiation States

ResearchMentor · Awarded by National Institutes of Health · 2019 - 2022

Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis

ResearchCo Investigator · Awarded by Department of Defense · 2018 - 2022

Role of oncogenic phosphorylated MED1 in aggressive prostate cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2022

Targeting castration-resistant prostate cancer by engineering 3'UTR

ResearchCollaborator · Awarded by Department of Defense · 2020 - 2022

Unveiling the roles of neuroendocrine cells in prostate cancer development

ResearchPrincipal Investigator · Awarded by Mike Slive Foundation · 2020 - 2021

Novel Tumor Suppressive Role of Phosphodiesterases in Prostate Cancer

ResearchPrincipal Investigator · Awarded by Department of Defense · 2016 - 2021

Histologic and Immunohistochemical Biomarkers for Heavily Treated Metastatic Prostate Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2021

Assessment of macrophage density in historical tNEPC tissue samples.

ResearchPrincipal Investigator · Awarded by BioXcel Therapeutics · 2019 - 2021

Identification of DNA methylation markers for risk of metastasis in localized prostate cancer

ResearchPrincipal Investigator · Awarded by Kaiser Permanente · 2016 - 2020

Heparan sulfate in prostate cancer

ResearchPrincipal Investigator · Awarded by University of South Florida · 2019 - 2020

Targeting Adaptive Pathways in Abiraterone- and Enzalutamide-Refractory Intermediate Atypical Carcinoma

ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2016 - 2019

Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma

ResearchCollaborator · Awarded by Fibrolamellar Cancer Foundation · 2016 - 2019

Genetic screen of calorie restricted and western diet essential kinases in prostate cancer

ResearchMentor · Awarded by Prostate Cancer Foundation · 2018 - 2019

Heparan sulfate in prostate cancer

ResearchPrincipal Investigator · Awarded by University of Georgia · 2018 - 2018

Paired Acquisition In Refractory Prostate Cancer (PAIR): Advancing the Promise of the PCF/SU2C/AACR West Coast Prostate Cancer Dream Team

ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2016 - 2018

A novel strategy to identify prostate cancer biomarkers for patient management

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2018

Systems Analysis of Epigenomic Architecture in Cancer Progression

ResearchPrincipal Investigator · Awarded by University of Texas Health Science Center at San Antonio · 2017 - 2018

: Identification of DNA methylation markers for risk of metastasis in localized prostate cancer

ResearchPrincipal Investigator · Awarded by Kaiser Permanente · 2016 - 2016

Stand Up 2 Cancer West Coast Dream Team Grant

ResearchPrincipal Investigator · Awarded by University of San Francisco · 2013 - 2016

External Relationships


  • Artera
  • Chimigen Bio
  • Kingmed Diagnostics
  • MoreHealth
  • OptraScan
  • SISU Pharma
  • York Biotechnology

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.