Scholars@Duke
Jiaoti Huang

Jiaoti Huang

Johnston-West Distinguished Professor of Pathology
Pathology

Selected Publications

Neuroendocrine Tumor as a Somatic-Type Malignancy in Metastatic Teratoma.

Journal Article Int J Surg Pathol · December 2025 Testicular germ cell tumors represent less than 1% of all cancer diagnoses in men. Postpubertal-type teratomas are a form of nonseminomatous germ cell tumor derived from 2 or more embryonic germ cell layers. Rarely, these tumors have been shown to develop ... Full text Link to item Cite

International Society of Urological Pathology Consensus on Cancer Precursor Lesions. Working Group 1: The Prostate.

Journal Article Am J Surg Pathol · December 1, 2025 Working Group 1 at ISUP's Cancer Precursors meeting (September 2024) evaluated 5 putative precursors of invasive prostate cancer: high-grade prostatic intraepithelial neoplasia (HGPIN), intraductal carcinoma (IDC), atypical intraductal proliferation (AIP), ... Full text Link to item Cite

Revisiting the role of metabolic reprogramming as a contributor to prostate cancer disease progression.

Journal Article Chin Med J (Engl) · November 21, 2025 Prostate cancer (PCa) is one of the most common malignancies worldwide, and metabolic reprogramming plays a crucial role, particularly in tumor progression and therapeutic resistance. As PCa progresses into advanced stages, such as castration-resistant pro ... Full text Link to item Cite

Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress.

Journal Article Clin Cancer Res · October 15, 2025 PURPOSE: Purine metabolism is a promising therapeutic target in cancer; however, how cancer cells respond to purine shortage, particularly their adaptation and vulnerabilities, remains unclear. EXPERIMENTAL DESIGN: Using the recently developed purine short ... Full text Link to item Cite

PRMT5:MEP50 Are Mediators of Treatment-Induced Neuroendocrine Differentiation in Prostate Cancer.

Journal Article Prostate · September 2025 BACKGROUND: Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer responsible for an estimated 20%-30% of castration-resistant prostate cancer (CRPC) deaths. While NEPC can arise spontaneously, the majority of these cases emerge as t ... Full text Link to item Cite

Single-dose cathepsin L CRISPR nanotherapy mitigates PASC-like lung damage in hamsters.

Journal Article Nano Res · September 2025 Respiratory post-acute sequelae of COVID-19 (PASC) persists in many SARS-CoV-2 survivors, yet no therapies specifically address its long-term pulmonary damage. We demonstrate that a single-dose CRISPR-CasRx nanotherapy targeting the host enzyme cathepsin L ... Full text Link to item Cite

Phase I, First-in-Human Study of FOR46 (FG-3246), an Immune-Modulating Antibody-Drug Conjugate Targeting CD46, in Patients With Metastatic Castration-Resistant Prostate Cancer.

Journal Article J Clin Oncol · May 20, 2025 PURPOSE: FOR46, a fully human antibody conjugated to monomethyl auristatin E, targets a tumor-selective epitope of CD46, which is overexpressed in metastatic castration-resistant prostate cancer (mCRPC). FOR46 demonstrates potent nonclinical activity in en ... Full text Link to item Cite

Resilience and vulnerabilities of tumor cells under purine shortage stress.

Journal Article bioRxiv · April 12, 2025 Purine metabolism is a promising therapeutic target in cancer; however how cancer cells respond to purine shortage,particularly their adaptation and vulnerabilities, remains unclear. Using the recently developed purine shortage-inducing prodrug DRP-104 and ... Full text Link to item Cite

Revisiting the use of CK7 and CK20 immunohistochemical stains in pathological diagnoses.

Journal Article Diagn Pathol · April 11, 2025 BACKGROUND: Cytokeratin-7 (keratin-7; CK7) and cytokeratin-20 (keratin-20; CK20) have been among the most widely used markers in pathology for prediction of tumor site of origin or classification. However, with the increased availability of newer and more ... Full text Link to item Cite

Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone.

Journal Article Clin Cancer Res · April 1, 2025 PURPOSE: After failing primary and secondary hormonal therapy, castration-resistant and neuroendocrine prostate cancer metastatic to the bone is invariably lethal, although treatment with docetaxel and carboplatin can modestly improve survival. Therefore, ... Full text Link to item Cite

Supplementary Table S1 from Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone

Other · April 1, 2025 <p>Primary antibodies used for immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB)</p> ... Full text Cite

Supplementary Figure S4 from Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone

Other · April 1, 2025 <p>Figure S4. Quantification of bone mineral density in mouse tibia specimen after treatment for 30 days. Batiraxcept and docetaxel as single agents or in combination increased bone mineral density (BMD) of the tibiae to a similar extent as d ... Full text Cite

Supplementary Figure S3 from Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone

Other · April 1, 2025 <p>Figure S3. Mouse serum PSA after treatment for 30 days. Batiraxcept and docetaxel as single agents or in combination significanty reduced mouse serum PSA detected by ELISA.</p> ... Full text Cite

Supplementary Figure S2 from Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone

Other · April 1, 2025 <p>Figure S2. Batiraxcept and docetaxel alone or in combination significantly inhibited bone tumor growth and metastasis in LuCaP mPCa AC PDX models. A-B, Representative images of Masson-Goldner staining and Ku70 IHC of PDX cells in the tibia ... Full text Cite

Supplementary Figure S1 from Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone

Other · April 1, 2025 <p>Figure S1. The levels of murine serum GAS6 before treatment in the LuCaP 147 PDX model. There were no significant differences in murine serum GAS6 levels among groups detected by ELISA</p> ... Full text Cite

Supplementary Figure S6 from Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone

Other · April 1, 2025 <p>Figure S6. IHC staining (continuing Fig. 6A) demonstrates batiraxcept alone or in combination with docetaxel reduced p-ERK1/2 protein levels compared to vehicle-treated controls in intratibial LuCaP 147CR PDX model while total AKT proteins ... Full text Cite

Supplementary Figure S5 from Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone

Other · April 1, 2025 <p>Figure S5. Mouse body weight change (%) after treatment for 30 days. None of the treatment groups displayed significant differences in body weight, indicating overall low toxicity from batiraxcept and docetaxel at the doses administered.&l ... Full text Cite

Data from Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone

Other · April 1, 2025 <div>AbstractPurpose:<p>After failing primary and secondary hormonal therapy, castration-resistant and neuroendocrine prostate cancer metastatic to the bone is invariably lethal, although treatment with docetaxel and carboplatin can mod ... Full text Cite

Framework for the Pathology Workup of Metastatic Castration-Resistant Prostate Cancer Biopsies.

Journal Article Clin Cancer Res · February 3, 2025 Lineage plasticity and histologic transformation from prostate adenocarcinoma to neuroendocrine (NE) prostate cancer (NEPC) occur in up to 15% to 20% of patients with castration-resistant prostate cancer (CRPC) as a mechanism of treatment resistance and ar ... Full text Link to item Cite

Genetic ancestry concordant RNA splicing in prostate cancer involves oncogenic genes and associates with recurrence.

Journal Article NPJ Precis Oncol · January 29, 2025 Black men suffer disproportionately from prostate cancer (PCa) compared to men of other races and ethnicities. Comparing the molecular landscape of PCa among Black and White patients has the potential to identify targets for development of new precision me ... Full text Link to item Cite

Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma.

Journal Article N Engl J Med · January 2, 2025 BACKGROUND: Muscle-invasive urothelial carcinoma is an aggressive disease with high rates of relapse. Whether pembrolizumab as adjuvant therapy would be effective in patients with high-risk muscle-invasive urothelial carcinoma after radical surgery is unkn ... Full text Link to item Cite

DNA methylation markers for risk of metastasis in a cohort of men with localized prostate cancer.

Journal Article Epigenetics · December 2024 Accurately identifying life-threatening prostate cancer (PCa) at time of diagnosis remains an unsolved problem. We evaluated whether DNA methylation status of selected candidate genes can predict the risk of metastasis beyond clinical risk factors in men w ... Full text Link to item Cite

Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1.

Chapter · November 4, 2024 Most patients with prostate adenocarcinoma develop resistance to therapies targeting the androgen receptor (AR). Consequently, a portion of these patients develop AR-independent neuroendocrine (NE) prostate cancer (NEPC), a rapidly progressing cancer with ... Full text Link to item Cite

IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation.

Journal Article J Exp Med · November 4, 2024 Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestrating this process. H ... Full text Link to item Cite

MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT.

Journal Article Sci Signal · June 11, 2024 Neuroendocrine prostate cancer (PCa) (NEPC), an aggressive subtype that is associated with poor prognosis, may arise after androgen deprivation therapy (ADT). We investigated the molecular mechanisms by which ADT induces neuroendocrine differentiation in a ... Full text Link to item Cite

Targeting glutamine dependence with DRP-104 inhibits proliferation and tumor growth of castration-resistant prostate cancer.

Journal Article Prostate · March 2024 BACKGROUND: Prostate cancer (PCa) continues to be one of the leading causes of cancer deaths in men. While androgen deprivation therapy is initially effective, castration-resistant PCa (CRPC) often recurs and has limited treatment options. Our previous stu ... Full text Link to item Cite

UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas.

Journal Article Cell Rep Med · February 20, 2024 Neuroendocrine carcinomas, such as neuroendocrine prostate cancer and small-cell lung cancer, commonly have a poor prognosis and limited therapeutic options. We report that ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is elev ... Full text Link to item Cite

Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival.

Journal Article Commun Biol · January 3, 2024 There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target. In this manuscript, we identify that HSF1 regulates the ... Full text Open Access Link to item Cite

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.

Journal Article Am J Surg Pathol · January 1, 2024 The 2022 International Society of Urological Pathology (ISUP) Consensus Conference on Urinary Bladder Cancer Working Group 2 was tasked to provide evidence-based proposals on the applications of grading in noninvasive urothelial carcinoma with mixed grades ... Full text Link to item Cite

International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4: Molecular Subtypes of Bladder Cancer-Principles of Classification and Emerging Clinical Utility.

Journal Article Am J Surg Pathol · January 1, 2024 Molecular subtyping has been a major focus of bladder cancer research over the past decade. Despite many promising associations with clinical outcomes and treatment response, its clinical impact has yet to be defined. As part of the 2022 International Soci ... Full text Link to item Cite

Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management.

Journal Article Cancers (Basel) · December 18, 2023 Recurrent prostate cancer after primary treatment with radiation therapy is a common problem. Patients with localized recurrence may benefit from salvage therapy, but careful patient selection is crucial because not all patients will benefit from local sal ... Full text Link to item Cite

Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.

Journal Article Cancer Cell · December 11, 2023 Trans-differentiation from an adenocarcinoma to a small cell neuroendocrine state is associated with therapy resistance in multiple cancer types. To gain insight into the underlying molecular events of the trans-differentiation, we perform a multi-omics ti ... Full text Link to item Cite

ACAA2 is a novel molecular indicator for cancers with neuroendocrine phenotype.

Journal Article Br J Cancer · November 2023 BACKGROUND: Neuroendocrine phenotype is commonly associated with therapy resistance and poor prognoses in small-cell neuroendocrine cancers (SCNCs), such as neuroendocrine prostate cancer (NEPC) and small-cell lung cancer (SCLC). Expression levels of curre ... Full text Link to item Cite

Genome-wide methylation profiling of diagnostic tumor specimens identified DNA methylation markers associated with metastasis among men with untreated localized prostate cancer.

Journal Article Cancer Med · September 2023 BACKGROUND: We used a genome-wide discovery approach to identify methylation markers associated with metastasis in men with localized prostate cancer (PCa), as better identification of those at high risk of metastasis can inform treatment decision-making. ... Full text Link to item Cite

Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer.

Journal Article Redox Biol · June 2023 Conventional treatment of prostate cancer (PCa) uses androgen-deprivation therapy (ADT) to inhibit androgen receptor (AR) signaling-driven tumor progression. ADT-induced PCa recurrence may progress to an AR-negative phenotype with neuroendocrine (NE) histo ... Full text Link to item Cite

RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis.

Journal Article J Clin Invest · May 15, 2023 Inactivation of the RB1 tumor suppressor gene is common in several types of therapy-resistant cancers, including metastatic castration-resistant prostate cancer, and predicts poor clinical outcomes. Effective therapeutic strategies against RB1-deficient ca ... Full text Open Access Link to item Cite

CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer.

Journal Article Cell Death Dis · May 4, 2023 Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling. Inhibiting effects of AR may activate neuroendocrine differentiation and lineage plasticity pathways, thereby promoting the development of neuroendocrine pro ... Full text Link to item Cite

Oncofetal protein glypican-3 is a biomarker and critical regulator of function for neuroendocrine cells in prostate cancer.

Journal Article J Pathol · May 2023 Neuroendocrine (NE) cells comprise ~1% of epithelial cells in benign prostate and prostatic adenocarcinoma (PCa). However, they become enriched in hormonally treated and castration-resistant PCa (CRPC). In addition, close to 20% of hormonally treated tumor ... Full text Link to item Cite

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma.

Journal Article Signal Transduct Target Ther · April 17, 2023 Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been under reported. To study the impact of intratumora ... Full text Link to item Cite

Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.

Journal Article NPJ Precis Oncol · February 24, 2023 An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival. Th ... Full text Link to item Cite

Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer.

Journal Article Cancer Res · January 18, 2023 UNLABELLED: Effective treatments for de novo and treatment-emergent small-cell/neuroendocrine (t-SCNC) prostate cancer represent an unmet need for this disease. Using metastatic biopsies from patients with advanced cancer, we demonstrate that delta-like li ... Full text Link to item Cite

The role of glutamine metabolism in castration-resistant prostate cancer.

Journal Article Asian J Androl · 2023 Reprogramming of metabolism is a hallmark of tumors, which has been explored for therapeutic purposes. Prostate cancer (PCa), particularly advanced and therapy-resistant PCa, displays unique metabolic properties. Targeting metabolic vulnerabilities in PCa ... Full text Link to item Cite

Androgen receptor and its correlation with estrogen and progesterone receptors, aimed for identification of cases for future anti-androgen therapy in endometrial cancers.

Journal Article PLoS One · 2023 INTRODUCTION: The expression of androgen receptor (AR) is not commonly tested or studied in uterine cancers, unlike estrogen receptor (ER) and progesterone receptor (PR) which are positive in most endometrial carcinomas. In this series, we evaluated the ex ... Full text Link to item Cite

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.

Journal Article Cancer Res · November 2, 2022 UNLABELLED: Analysis of DNA methylation is a valuable tool to understand disease progression and is increasingly being used to create diagnostic and prognostic clinical biomarkers. While conversion of cytosine to 5-methylcytosine (5mC) commonly results in ... Full text Link to item Cite

Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection.

Journal Article Nat Chem Biol · October 2022 SARS-CoV-2 entry into cells requires specific host proteases; however, no successful in vivo applications of host protease inhibitors have yet been reported for treatment of SARS-CoV-2 pathogenesis. Here we describe a chemically engineered nanosystem encap ... Full text Link to item Cite

Reconciling Discordance Between Prostate Biopsy Histology and Magnetic Resonance Imaging Suspicion - Implementation of a Quality Improvement Protocol of Imaging Re-review and Reverse-fusion Target Analysis.

Journal Article Eur Urol Oncol · October 2022 There is uncertainty with how to proceed when targeted prostate biopsy of suspicious multiparametric magnetic resonance imaging (mpMRI) lesions return without clinically significant prostate cancer (csPCa). While possible, there are error sources that coul ... Full text Link to item Cite

Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.

Journal Article Nat Commun · September 15, 2022 The androgen receptor (AR) signaling inhibitor enzalutamide (enza) is one of the principal treatments for metastatic castration-resistant prostate cancer (CRPC). Several emergent enza clinical resistance mechanisms have been described, including lineage pl ... Full text Link to item Cite

Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.

Conference Prostate Cancer Prostatic Dis · September 2022 BACKGROUND: Prostate cancer is a clinically and molecularly heterogeneous disease, with highest incidence and mortality among men of African ancestry. To date, prostate cancer patient-derived xenograft (PCPDX) models to study this disease have been difficu ... Full text Open Access Link to item Cite

Structured approach to resolving discordance between PI-RADS v2.1 score and targeted prostate biopsy results: an opportunity for quality improvement.

Journal Article Abdom Radiol (NY) · August 2022 BACKGROUND: Prostate multiparametric magnetic resonance imaging (mpMRI) can identify lesions within the prostate with characteristics identified in Prostate Imaging Reporting and Data System (PI-RADS) v2.1 associated with clinically significant prostate ca ... Full text Link to item Cite

A Hybrid Human-Machine Learning Approach for Screening Prostate Biopsies Can Improve Clinical Efficiency Without Compromising Diagnostic Accuracy.

Journal Article Arch Pathol Lab Med · June 1, 2022 CONTEXT.—: Prostate cancer is a common malignancy, and accurate diagnosis typically requires histologic review of multiple prostate core biopsies per patient. As pathology volumes and complexity increase, new tools to improve the efficiency of everyday pra ... Full text Link to item Cite

Phosphorylated MED1 links transcription recycling and cancer growth.

Journal Article Nucleic Acids Res · May 6, 2022 Mediator activates RNA polymerase II (Pol II) function during transcription, but it remains unclear whether Mediator is able to travel with Pol II and regulate Pol II transcription beyond the initiation and early elongation steps. By using in vitro and in ... Full text Link to item Cite

Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.

Journal Article Eur Urol · May 2022 BACKGROUND: Hormonal therapy targeting the androgen receptor inhibits prostate cancer (PCa), but the tumor eventually recurs as castration-resistant prostate cancer (CRPC). OBJECTIVE: To understand the mechanisms by which subclones within early PCa develop ... Full text Open Access Link to item Cite

A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · April 2022 BACKGROUND: Men with progressive neuroendocrine or aggressive-variant metastatic prostate cancer (NEPC/AVPC) have a poor prognosis and limited treatment options, and immunotherapy has not been tested in such patients. METHODS: We conducted an open label si ... Full text Link to item Cite

Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency.

Journal Article Cell Death Dis · March 19, 2022 Neuroendocrine differentiation (NED) frequently occurs in androgen-deprivation therapy (ADT)-resistant prostate cancer (PCa) and is typically associated with metabolic pathway alterations, acquisition of lineage plasticity, and malignancy. There is no conv ... Full text Link to item Cite

PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.

Journal Article Br J Cancer · March 2022 BACKGROUND: Castration-resistant prostate cancer (CRPC) patients frequently develop neuroendocrine differentiation, with high mortality and no effective treatment. However, the regulatory mechanism that connects neuroendocrine differentiation and metabolic ... Full text Link to item Cite

Targeting Protein Arginine Methyltransferase 5 Suppresses Radiation-induced Neuroendocrine Differentiation and Sensitizes Prostate Cancer Cells to Radiation.

Journal Article Mol Cancer Ther · March 1, 2022 Prostate cancer remains the second leading cause of cancer death among American men. Radiotherapy is a potentially curative treatment for localized prostate cancer, and failure to control localized disease contributes to the majority of prostate cancer dea ... Full text Link to item Cite

Clinical and molecular features of low prostate-specific membrane antigen (PSMA) expression in patients (pts) with metastatic castration resistant prostate cancer (mCRPC).

Conference Journal of Clinical Oncology · February 20, 2022 167 Background: Low PSMA uptake on positron-emission tomography is seen in up to 30% of mCRPC pts and represents a clinically distinct subgroup with adverse outcomes. We assessed transcriptional and clinical features associated w ... Full text Cite

A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.

Journal Article Carcinogenesis · February 11, 2022 ATM (ataxia-telangiectasia mutated) is an important cell-cycle checkpoint kinase required for cellular response to DNA damage. Activated by DNA double strand breaks, ATM regulates the activities of many downstream proteins involved in various carcinogenic ... Full text Open Access Link to item Cite

Targeting glutamine metabolism network for the treatment of therapy-resistant prostate cancer.

Journal Article Oncogene · February 2022 Advanced and aggressive prostate cancer (PCa) depends on glutamine for survival and proliferation. We have previously shown that inhibition of glutaminase 1, which catalyzes the rate-limiting step of glutamine catabolism, achieves significant therapeutic e ... Full text Link to item Cite

Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology.

Journal Article Clin Cancer Res · January 15, 2022 Every profession has an essential, behind-the-scenes component without which it cannot function. Medicine is no exception. Pathologists are one of medicine's group of specialists whose work as diagnosticians is critical for patient care. This article descr ... Full text Link to item Cite

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.

Journal Article Mol Cancer Ther · January 2022 A noninvasive test to discriminate indolent prostate cancers from lethal ones would focus treatment where necessary while reducing overtreatment. We exploited the known activity of heat shock protein 90 (Hsp90) as a chaperone critical for the function of n ... Full text Link to item Cite

TCF7L1 regulates cytokine response and neuroendocrine differentiation of prostate cancer.

Journal Article Oncogenesis · November 20, 2021 Neuroendocrine differentiation (NED) is associated with WNT signaling activation and can be significantly observed after failure of androgen-deprivation therapy (ADT) for prostatic adenocarcinomas. Cytokine signaling is stimulated in NED prostate cancer; h ... Full text Link to item Cite

Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer.

Journal Article JAMA Oncol · November 1, 2021 IMPORTANCE: Luminal and basal subtypes of primary prostate cancer have been shown to be molecularly distinct and clinically important in predicting response to therapy. These subtypes have not been described in metastatic prostate cancer. OBJECTIVES: To id ... Full text Link to item Cite

Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling.

Journal Article Nature communications · November 2021 RNA Polymerase II (Pol II) transcriptional recycling is a mechanism for which the required factors and contributions to overall gene expression levels are poorly understood. We describe an in vitro methodology facilitating unbiased identification of putati ... Full text Cite

Tissue clearing techniques for three-dimensional optical imaging of intact human prostate and correlations with multi-parametric MRI.

Journal Article Prostate · June 2021 BACKGROUND: Tissue clearing technologies have enabled remarkable advancements for in situ characterization of tissues and exploration of the three-dimensional (3D) relationships between cells, however, these studies have predominantly been performed in non ... Full text Link to item Cite

Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer.

Journal Article Nucleic Acids Res · May 21, 2021 Castration-resistant prostate cancer (CRPC) is a terminal disease and the molecular underpinnings of CRPC development need to be better understood in order to improve its treatment. Here, we report that a transcription factor Yin Yang 1 (YY1) is significan ... Full text Open Access Link to item Cite

Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey.

Journal Article Urol Oncol · May 2021 PURPOSE: To survey urologic clinicians regarding interpretation of and practice patterns in relation to emerging aspects of prostate cancer grading, including quantification of high-grade disease, cribriform/intraductal carcinoma, and impact of magnetic re ... Full text Link to item Cite

The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer.

Journal Article Arch Pathol Lab Med · April 1, 2021 CONTEXT.—: Controversies and uncertainty persist in prostate cancer grading. OBJECTIVE.—: To update grading recommendations. DATA SOURCES.—: Critical review of the literature along with pathology and clinician surveys. CONCLUSIONS.—: Percent Gleason patter ... Full text Link to item Cite

A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.

Journal Article Proc Natl Acad Sci U S A · March 30, 2021 Cellular metabolism in cancer is significantly altered to support the uncontrolled tumor growth. How metabolic alterations contribute to hormonal therapy resistance and disease progression in prostate cancer (PCa) remains poorly understood. Here we report ... Full text Link to item Cite

Clinical and genomic characterization of Low PSA Secretors: a unique subset of metastatic castration resistant prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · March 2021 BACKGROUND: Metastatic disease burden out of proportion to serum PSA has been used as a marker of aggressive phenotype prostate cancer but is not well defined as a distinct subgroup. We sought to prospectively characterize the molecular features and clinic ... Full text Link to item Cite

Neuroendocrine cells of the prostate: Histology, biological functions, and molecular mechanisms.

Journal Article Precis Clin Med · March 2021 Prostate cancer (PCa) is a common cause of cancer-related mortality in men worldwide. Although most men are diagnosed with low grade, indolent tumors that are potentially curable, a significant subset develops advanced disease where hormone therapy is requ ... Full text Link to item Cite

Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.

Journal Article Oncogene · March 2021 Fatty acid metabolism is essential for the biogenesis of cellular components and ATP production to sustain proliferation of cancer cells. Long-chain fatty acyl-CoA synthetases (ACSLs), a group of rate-limiting enzymes in fatty acid metabolism, catalyze the ... Full text Link to item Cite

Efficacy of the PD-L1 inhibitor avelumab in neuroendocrine or aggressive variant prostate cancer: Results from a phase II, single-arm study.

Conference Journal of Clinical Oncology · February 20, 2021 89 Background: Men with metastatic neuroendocrine/small cell and aggressive variant prostate cancer (NEPC/AVPC) have poor outcomes despite platinum and taxane chemotherapy. These tumors share common features with small cell lung ... Full text Cite

Urinary Pubic Symphysis Fistula Leads to Histopathologic Osteomyelitis in Prostate Cancer Survivors.

Journal Article Urology · February 2021 OBJECTIVE: To assess the histologic findings in the pubic bone resected during extirpative surgery for urinary pubic symphysis fistula (UPF). The concurrent presence of osteomyelitis and the need for bone resection at time of extirpative surgery for UPF ha ... Full text Open Access Link to item Cite

Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance.

Journal Article Commun Biol · January 4, 2021 Nerve growth factor (NGF) contributes to the progression of malignancy. However, the functional role and regulatory mechanisms of NGF in the development of neuroendocrine prostate cancer (NEPC) are unclear. Here, we show that an androgen-deprivation therap ... Full text Link to item Cite

Plectin is a regulator of prostate cancer growth and metastasis.

Journal Article Oncogene · January 2021 Prostate cancer is responsible for over 30,000 US deaths annually, attributed largely to incurable metastatic disease. Here, we demonstrate that high levels of plectin are associated with localized and metastatic human prostate cancer when compared to beni ... Full text Link to item Cite

Glycosylation Changes in Prostate Cancer Progression.

Journal Article Front Oncol · 2021 Prostate Cancer (PCa) is the most commonly diagnosed malignancy and second leading cause of cancer-related mortality in men. With the use of next generation sequencing and proteomic platforms, new biomarkers are constantly being developed to both improve d ... Full text Link to item Cite

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.

Journal Article Sci Transl Med · December 16, 2020 Heat shock factor 1 (HSF1) is a cellular stress-protective transcription factor exploited by a wide range of cancers to drive proliferation, survival, invasion, and metastasis. Nuclear HSF1 abundance is a prognostic indicator for cancer severity, therapy r ... Full text Link to item Cite

PD-L1 Assay Concordance in Metastatic Renal Cell Carcinoma and Metastatic Urothelial Carcinoma.

Journal Article Clin Genitourin Cancer · December 2020 BACKGROUND: Immune checkpoint inhibitors are now standard of care for many patients with metastatic renal cell carcinoma (mRCC) and metastatic urothelial carcinoma (mUC). Given real-world limitations in programmed death-ligand 1 (PD-L1) testing, concordanc ... Full text Link to item Cite

Down-regulation of ADRB2 expression is associated with small cell neuroendocrine prostate cancer and adverse clinical outcomes in castration-resistant prostate cancer.

Journal Article Urol Oncol · December 2020 OBJECTIVES: The net oncogenic effect of β2-adrenergic receptor ADRB2, whose downstream elements induce neuroendocrine differentiation and whose expression is regulated by EZH2, is unclear. ADRB2 expression and associated clinical outcomes in metastatic cas ... Full text Link to item Cite

Multiparametric Ultrasound for Targeting Prostate Cancer: Combining ARFI, SWEI, QUS and B-Mode.

Journal Article Ultrasound Med Biol · December 2020 Diagnosing prostate cancer through standard transrectal ultrasound (TRUS)-guided biopsy is challenging because of the sensitivity and specificity limitations of B-mode imaging. We used a linear support vector machine (SVM) to combine standard TRUS imaging ... Full text Link to item Cite

Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer.

Journal Article Cancer Res · November 15, 2020 The majority of advanced prostate cancer therapies aim to inhibit androgen receptor (AR) signaling. However, AR reactivation inevitably drives disease progression to castration-resistant prostate cancer (CRPC). Here we demonstrate that protein arginine met ... Full text Link to item Cite

LIN28B promotes the development of neuroendocrine prostate cancer.

Journal Article J Clin Invest · October 1, 2020 Therapy-induced neuroendocrine prostate cancer (t-NEPC) is a highly aggressive subtype of prostate cancer with poor patient survival. Emerging evidence indicates that t-NEPC can develop when prostate adenocarcinoma cells acquire cancer stem-like cell signa ... Full text Link to item Cite

EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.

Journal Article Oncogene · October 2020 Neuroendocrine (NE) differentiation is a well-recognized phenotypic change of prostate cancer after androgen deprivation therapy (ADT), and it ultimately develops into an aggressive subset of this disease. However, the contribution of signaling pathways th ... Full text Link to item Cite

Prostate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range.

Journal Article Transl Oncol · September 2020 Widespread cGMP-specific phosphodiesterase 5 (PDE5) inhibitor use in male reproductive health and particularly in prostate cancer patients following surgery has generated interest in how these drugs affect the ability of residual tumor cells to proliferate ... Full text Link to item Cite

Copy Number Loss of 17q22 Is Associated with Enzalutamide Resistance and Poor Prognosis in Metastatic Castration-Resistant Prostate Cancer.

Journal Article Clin Cancer Res · September 1, 2020 PURPOSE: The purpose of this study was to measure genomic changes that emerge with enzalutamide treatment using analyses of whole-genome sequencing and RNA sequencing. EXPERIMENTAL DESIGN: One hundred and one tumors from men with metastatic castration-resi ... Full text Link to item Cite

The DNA methylation landscape of advanced prostate cancer.

Journal Article Nat Genet · August 2020 Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through whole-genome bisulfite sequencing paired with deep whole-genome and transcriptome sequencing of 100 ... Full text Link to item Cite

Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis.

Journal Article Nat Plants · July 2020 Histone demethylation is crucial for proper chromatin structure and to ensure normal development, and requires the large family of Jumonji C (JmjC)-containing demethylases; however, the molecular mechanisms that regulate the substrate specificity of these ... Full text Link to item Cite

Author Correction: LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.

Journal Article Nat Commun · June 4, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance.

Journal Article Proc Natl Acad Sci U S A · June 2, 2020 The androgen receptor (AR) antagonist enzalutamide is one of the principal treatments for men with castration-resistant prostate cancer (CRPC). However, not all patients respond, and resistance mechanisms are largely unknown. We hypothesized that genomic a ... Full text Link to item Cite

Abstract A114: Characterization of a metastatic prostate cancer xenograft derived from a patient of African ancestry

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractBackground: Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with differences in incidence and mortality among and between racial groups, which grade and stage only partia ... Full text Cite

Prostate Cancer Detection Rate of Freehand versus 3-Dimensional Template Mapping Biopsy Using a Magnetic Resonance Imaging-Ultrasound Fusion Device in Biopsy Naïve Men.

Journal Article J Urol · April 2020 PURPOSE: Targeted prostate biopsy devices include a 3-dimensional digital template grid to guide systematic biopsy locations. Following a template could better ensure uniform and well distributed sampling of the prostate compared to the traditional freehan ... Full text Link to item Cite

Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC.

Journal Article Prostate Cancer Prostatic Dis · March 2020 BACKGROUNDS: p53 is a tumor suppressor that prevents cancer onset and progression, and mutations in the p53 gene cause loss of the tumor suppressor function of the protein. The mutant p53 protein in tumor cells can form aggregates which contribute to the d ... Full text Open Access Link to item Cite

Morphologic Spectrum of Neuroendocrine Tumors of the Prostate: An Updated Review.

Journal Article Arch Pathol Lab Med · March 2020 CONTEXT.—: The incidence of neuroendocrine tumors of the prostate increases after hormonal therapy. Neuroendocrine tumors possess a broad spectrum of morphologic features and pose challenges in the pathologic diagnosis and clinical management of patients. ... Full text Link to item Cite

Frontiers in Genitourinary Pathology.

Journal Article Arch Pathol Lab Med · March 2020 This special section includes 4 articles as the proceedings of the Fifth Princeton Integrated Pathology Symposium (PIPS): Genitourinary Pathology, and an update on neuroendocrine tumor of the prostate. The symposium took place at the Princeton Medical Cent ... Full text Link to item Cite

ADRB2 expression in progressive metastatic castration-resistant prostate cancer

Conference JOURNAL OF CLINICAL ONCOLOGY · February 20, 2020 Link to item Cite

PRMT5 Cooperates with pICln to Function as a Master Epigenetic Activator of DNA Double-Strand Break Repair Genes.

Journal Article iScience · January 24, 2020 DNA double-strand break (DSB) repair is critical for cell survival and genome integrity. Upon recognition of DSBs, repair proteins are transiently upregulated to facilitate repair through homologous recombination (HR) or non-homologous end joining (NHEJ). ... Full text Link to item Cite

A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.

Journal Article Proc Natl Acad Sci U S A · January 7, 2020 Small cell carcinoma of the bladder (SCCB) is a rare and lethal phenotype of bladder cancer. The pathogenesis and molecular features are unknown. Here, we established a genetically engineered SCCB model and a cohort of patient SCCB and urothelial carcinoma ... Full text Link to item Cite

Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer.

Journal Article Sci Transl Med · December 4, 2019 Hormonal therapy targeting androgen receptor (AR) is initially effective to treat prostate cancer (PCa), but it eventually fails. It has been hypothesized that cellular heterogeneity of PCa, consisting of AR+ luminal tumor cells and AR- neuroendocrine (NE) ... Full text Link to item Cite

LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.

Journal Article Nat Commun · December 2, 2019 LRIG1 has been reported to be a tumor suppressor in gastrointestinal tract and epidermis. However, little is known about the expression, regulation and biological functions of LRIG1 in prostate cancer (PCa). We find that LRIG1 is overexpressed in PCa, but ... Full text Link to item Cite

MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · December 2019 BACKGROUND: Metastatic castration resistant prostate cancer (mCRPC) is incurable and progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus, there is an urgent need to develop more effective treatments beyond hormonal ... Full text Link to item Cite

Initial Evaluation of a Novel Modulated Radiofrequency-based Bladder Denervation Device.

Journal Article Urology · December 2019 OBJECTIVE: To determine if targeted and modulated radiofrequency ablation (RFA) of the urinary bladder using our novel ablation device (Denerblate) reduces bladder nerve density, potentially leading to a novel strategy for the management of overactive blad ... Full text Link to item Cite

Molecular determinants for enzalutamide-induced transcription in prostate cancer.

Journal Article Nucleic Acids Res · November 4, 2019 Enzalutamide, a second-generation androgen receptor (AR) antagonist, has demonstrated clinical benefit in men with prostate cancer. However, it only provides a temporary response and modest increase in survival, indicating a rapid evolution of resistance. ... Full text Open Access Link to item Cite

Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer.

Journal Article Eur Urol · November 2019 BACKGROUND: Metastatic castration-resistant prostate cancer (mCRPC) is the lethal form of the disease. Several recent studies have identified genomic alterations in mCRPC, but the clinical implications of these genomic alterations have not been fully eluci ... Full text Link to item Cite

Multiparametric Ultrasound for the Targeting of Prostate Cancer using ARFI, SWEI, B-mode, and QUS

Conference IEEE International Ultrasonics Symposium Ius · October 1, 2019 Prostate cancer diagnosis using standard transrectal ultrasound (TRUS) and systematic biopsy is challenging. To improve the performance of TRUS imaging, we combined it with acoustic radiation force impulse (ARFI) imaging and shear wave elasticity imaging ( ... Full text Cite

The expanded role of fatty acid metabolism in cancer: new aspects and targets.

Journal Article Precis Clin Med · September 2019 Cancer cells undergo metabolic reprogramming to support cell proliferation, growth, and dissemination. Alterations in lipid metabolism, and specifically the uptake and synthesis of fatty acids (FAs), comprise one well-documented aspect of this reprogrammin ... Full text Open Access Link to item Cite

The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients.

Journal Article Precis Clin Med · September 2019 Circulating cell-free DNAs (cfDNAs) are fragmented DNA molecules released into the blood by cells. Previous studies have suggested that mitochondria-originated cfDNA fragments (mt-cfDNAs) in cancer patients are more fragmented than those from healthy contr ... Full text Link to item Cite

RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression.

Journal Article Eur Urol · August 2019 BACKGROUND: Prostate adenocarcinoma (AdPC) progression to treatment-induced neuroendocrine prostate cancer (t-NEPC) is associated with poor patient survival. While AdPC and t-NEPC share similar genomes, they possess distinct transcriptomes, suggesting that ... Full text Link to item Cite

Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies.

Journal Article Cancer Cell · July 8, 2019 Small-cell neuroendocrine cancers (SCNCs) are an aggressive cancer subtype. Transdifferentiation toward an SCN phenotype has been reported as a resistance route in response to targeted therapies. Here, we identified a convergence to an SCN state that is wi ... Full text Link to item Cite

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46.

Journal Article Clin Cancer Res · July 1, 2019 PURPOSE: The molecular targets for castration-resistant prostate cancer (CRPC) are unknown because the disease inevitably recurs, and therapeutic approaches for patients with CRPC remain less well understood. We sought to investigate regulatory mechanisms ... Full text Link to item Cite

Abstract 1149: Systems pathology by Optra 30 color multiplex immunofluorescence automated whole slide imaging system integrated with image analysis

Conference Cancer Research · July 1, 2019 AbstractBackground A paradigm shift from single marker immunohistochemistry (IHC) to multiplexing in molecular histopathology has helped better understand the cellular composition and heterogeneity of sub ... Full text Cite

Correction to: N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ ATM pathway.

Journal Article Mol Cancer · June 19, 2019 Following publication of the original article [1], the authors reported that name that appeared in published online version is incorrect. Aifeng Wang should be Aifen Wang. Corrected name is provided in the author group section above. ... Full text Link to item Cite

Predicting clinical outcome of therapy-resistant prostate cancer.

Journal Article Proc Natl Acad Sci U S A · June 4, 2019 Full text Link to item Cite

Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity.

Journal Article Mol Cancer Res · June 2019 Therapeutic resistance in metastatic castration-resistant prostate cancer (mCRPC) can be accompanied by treatment-emergent small-cell neuroendocrine carcinoma (t-SCNC), a morphologically distinct subtype. We performed integrative whole-genome and -transcri ... Full text Link to item Cite

Detection and Localization of Prostate Cancer at 3-T Multiparametric MRI Using PI-RADS Segmentation.

Journal Article AJR Am J Roentgenol · June 2019 OBJECTIVE. The purpose of this study is to determine the overall and sector-based performance of 3-T multiparametric MRI for prostate cancer (PCa) detection and localization by using Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) scoring ... Full text Link to item Cite

Concordance between PD-L1 assays for metastatic renal cell carcinoma (mRCC) and metastatic urothelial carcinoma (mUC).

Conference Journal of Clinical Oncology · May 20, 2019 e14259 Background: Immune checkpoint inhibitors (ICIs) are standard of care for mRCC and mUC patients (pts). PD-L1 status is gaining importance as a predictive biomarker, particularly for cisplatin-ineligible mUC. PD-L1 positivit ... Full text Cite

DHX15 is up-regulated in castration-resistant prostate cancer and required for androgen receptor sensitivity to low DHT concentrations.

Journal Article Prostate · May 2019 BACKGROUND: DHX15 is a member of the DEAH-box (DHX) RNA helicase family. Our previous study identified it as an AR coactivator which contributes to prostate cancer progression. METHODS: We investigated DHX15 expression in castration resistant prostate canc ... Full text Link to item Cite

A Multi-Institutional Study to Evaluate Automated Whole Slide Scoring of Immunohistochemistry for Assessment of Programmed Death-Ligand 1 (PD-L1) Expression in Non-Small Cell Lung Cancer.

Journal Article Appl Immunohistochem Mol Morphol · April 2019 Assessment of programmed death-ligand 1 (PD-L1) expression is a critical part of patient management for immunotherapy. However, studies have shown that pathologist-based analysis lacks reproducibility, especially for immune cell expression. The purpose of ... Full text Link to item Cite

Concordance between PD-L1 assays for metastatic renal cell carcinoma (mRCC) and metastatic urothelial carcinoma (mUC).

Conference Journal of Clinical Oncology · March 1, 2019 577 Background: Immune checkpoint inhibitors (ICIs) are now standard of care for mRCC and mUC patients (pts). PD-L1 status is gaining importance as a predictive biomarker, particularly for cisplatin-ineligible mUC. Four different ... Full text Cite

SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.

Journal Article Dev Cell · February 11, 2019 Frequent SPOP mutation defines the molecular feature underlying one of seven sub-types of human prostate cancer (PrCa). However, it remains largely elusive how SPOP functions as a tumor suppressor in PrCa. Here, we report that SPOP suppresses stem cell tra ... Full text Open Access Link to item Cite

Reply to A. Dalla Volta et al.

Journal Article J Clin Oncol · February 1, 2019 Full text Link to item Cite

N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway.

Journal Article Mol Cancer · January 18, 2019 BACKGROUND: MYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. N-Myc has been demonstrated to drive disease progression and hormonal therapeutic resistance of NEPC/CRPC. Here, we aim to identify the m ... Full text Link to item Cite

SRRM4 gene expression correlates with neuroendocrine prostate cancer.

Journal Article Prostate · January 2019 Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of castrate-resistant prostate cancer characterized by poor patient outcome. Whole transcriptome sequencing analyses identified a NEPC-specific RNA splicing program that is predominantly contro ... Full text Link to item Cite

ATM deficiency promotes progression of CRPC by enhancing Warburg effect.

Journal Article Endocr Relat Cancer · January 1, 2019 ATM is a well-known master regulator of double strand break (DSB) DNA repair and the defective DNA repair has been therapeutically exploited to develop PARP inhibitors based on the synthetic lethality strategy. ATM mutation is found with increased prevalen ... Full text Link to item Cite

Making a Tissue Microarray.

Journal Article Methods Mol Biol · 2019 Tissue microarray (TMA) is a widely used, high-throughput, cost-effective, and tissue and reagent-conserving method of performing molecular analysis. Multiple donor tissue cores are procured and transferred into a recipient TMA block for simultaneous diffe ... Full text Link to item Cite

Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer.

Journal Article Asian J Urol · January 2019 Since androgen receptor (AR) signaling is critically required for the development of prostate cancer (PCa), targeting AR axis has been the standard treatment of choice for advanced and metastatic PCa. Unfortunately, although the tumor initially responds to ... Full text Open Access Link to item Cite

Prostate cancer: molecular and cellular mechanisms and their implications in therapy resistance and disease progression.

Journal Article Asian J Androl · 2019 Prostate cancer is among the most common malignancies in Western countries, and its incidence is rapidly rising in Asia where it was traditionally considered an uncommon tumor. Our understanding of the disease and management strategies continue to evolve. ... Full text Link to item Cite

Neuroendocrine cells of prostate cancer: biologic functions and molecular mechanisms.

Journal Article Asian J Androl · 2019 Prostate cancer (PCa) is a major health risk for older men worldwide. Existing systemic therapies mostly target androgen receptor (AR). Although treatments are initially effective, the disease always recurs. A potential mechanism for the treatment failure ... Full text Link to item Cite

The promise of immunotherapy in genitourinary malignancies.

Journal Article Precis Clin Med · December 2018 A broad understanding of the tumor immune landscape has led to a revolution of immune checkpoint inhibitors in the treatment of multiple cancer types. In genitourinary malignancies, immune checkpoint inhibitors have improved outcomes for patients with meta ... Full text Link to item Cite

Three-dimensional localization and targeting of prostate cancer foci with imaging and histopathologic correlation: establishing a multidisciplinary team for quality improvement.

Journal Article Curr Opin Urol · November 2018 PURPOSE OF REVIEW: The current trend in image-based identification and characterization of prostate cancer (PCa) utilizing multiparametric MRI (mpMRI) has affected diagnostic and treatment planning in terms of targeted biopsy, risk stratification and progn ... Full text Link to item Cite

Receptor activator of NF-κB (RANK)-mediated induction of metastatic spread and association with poor prognosis in renal cell carcinoma.

Journal Article Urol Oncol · November 2018 BACKGROUND: Inhibition of the receptor activator of NF-κB ligand (RANKL) has become a standard of care supportive treatment to prevent skeletal related events in cancer patients. Moreover, RANKL inhibition has been implicated with better survival outcome i ... Full text Link to item Cite

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage.

Journal Article Science · October 5, 2018 The use of potent therapies inhibiting critical oncogenic pathways active in epithelial cancers has led to multiple resistance mechanisms, including the development of highly aggressive, small cell neuroendocrine carcinoma (SCNC). SCNC patients have a dism ... Full text Link to item Cite

A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.

Journal Article Cell Rep · September 18, 2018 Cancer progression to an aggressive phenotype often co-opts aspects of stem cell biology. Here, we developed gene signatures for normal human stem cell populations to understand the relationship between epithelial cancers and stem cell transcriptional prog ... Full text Link to item Cite

Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses.

Journal Article Nat Commun · September 6, 2018 Expression of androgen receptor (AR) in prostate cancer (PCa) is heterogeneous but the functional significance of AR heterogeneity remains unclear. Screening ~200 castration-resistant PCa (CRPC) cores and whole-mount sections (from 89 patients) reveals 3 A ... Full text Link to item Cite

Building a high-resolution T2-weighted MR-based probabilistic model of tumor occurrence in the prostate.

Journal Article Abdom Radiol (NY) · September 2018 PURPOSE: We present a method for generating a T2 MR-based probabilistic model of tumor occurrence in the prostate to guide the selection of anatomical sites for targeted biopsies and serve as a diagnostic tool to aid radiological evaluation of prostate can ... Full text Link to item Cite

Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells.

Journal Article Sci Rep · August 21, 2018 The concept that human cancer is in essence a genetic disease driven by gene mutations has been well established, yet its utilization in functional studies of cancer genes has not been fully explored. Here, we describe a simple genetics-based approach that ... Full text Link to item Cite

Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.

Journal Article J Clin Oncol · August 20, 2018 Purpose The prevalence and features of treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) are not well characterized in the era of modern androgen receptor (AR)-targeting therapy. We sought to characterize the clinical and genomic featur ... Full text Link to item Cite

Abstract A031: Androgen deprivation therapy-induced TGFBI signaling promotes EMT and bone metastasis of prostate cancer

Conference Cancer Research · August 15, 2018 AbstractMetastatic progression in patients with prostate cancer is common despite pharmacologic inhibition of androgen receptor signaling. This drug resistance is associated with increased signaling through ... Full text Cite

Multiparametric Prostate MR Imaging: Impact on Clinical Staging and Decision Making.

Journal Article Urol Clin North Am · August 2018 Meaningful changes to the approach of prostate cancer staging and management have been made over the past decade with increasing demand for high-quality multiparametric MR imaging (mpMRI) of the prostate. This article focuses on the evolving paradigm of pr ... Full text Link to item Cite

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Journal Article Cell · July 26, 2018 While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant pr ... Full text Link to item Cite

Percutaneous image-guided core biopsy of solid renal masses: analysis of safety, efficacy, pathologic interpretation, and clinical significance.

Journal Article Abdom Radiol (NY) · July 2018 PURPOSE: To determine the efficacy, safety and clinical utility of CT and US-guided percutaneous renal mass biopsy. MATERIALS AND METHODS: A retrospective IRB-approved, HIPAA-compliant study of a cohort of 183 consecutive patients who underwent percutaneou ... Full text Link to item Cite

Abstract 1695: A multi-institutional study to evaluate automated scoring of immunohistochemistry slides for assessment of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer

Conference Cancer Research · July 1, 2018 AbstractPurpose: Assessment of PD-L1 expression is a critical part of patient management for immunotherapy. However, studies have shown that pathologist-based analysis lacks reproducibility, especially for i ... Full text Cite

Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13.

Journal Article Proc Natl Acad Sci U S A · June 26, 2018 The constitutively active androgen receptor (AR) splice variant 7 (AR-V7) plays an important role in the progression of castration-resistant prostate cancer (CRPC). Although biomarker studies established the role of AR-V7 in resistance to AR-targeting ther ... Full text Link to item Cite

Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer.

Journal Article Proc Natl Acad Sci U S A · May 8, 2018 Prostate cancer is a heterogeneous disease composed of divergent molecular and histologic subtypes, including prostate adenocarcinoma (PrAd) and neuroendocrine prostate cancer (NEPC). While PrAd is the major histology in prostate cancer, NEPC can evolve fr ... Full text Link to item Cite

Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.

Journal Article EBioMedicine · May 2018 Treatment-induced neuroendocrine prostate cancer (t-NEPC) is an aggressive subtype of prostate cancer (PCa) that becomes more prevalent when hormonal therapy, chemotherapy, or radiation therapy is applied to patients with metastatic prostate adenocarcinoma ... Full text Link to item Cite

Evaluation and Comparison of Contemporary Energy-Based Surgical Vessel Sealing Devices.

Journal Article J Endourol · April 2018 INTRODUCTION: We evaluated and compared five currently available energy-based vessel sealing devices to assess typical surgical metrics. METHODS: We tested Caiman 5 (C5), Harmonic Scalpel Ace Plus (HA), Harmonic Ace +7 (HA7), LigaSure (LS), and Enseal G2 ( ... Full text Link to item Cite

New prostate cancer prognostic grade group (PGG): Can multiparametric MRI (mpMRI) accurately separate patients with low-, intermediate-, and high-grade cancer?

Journal Article Abdom Radiol (NY) · March 2018 PURPOSE: Our objective is to determine the accuracy of multiparametric MRI (mpMRI) in predicting pathologic grade of prostate cancer (PCa) after radical prostatectomy (RP) using simple apparent diffusion coefficient metrics and, specifically, whether mpMRI ... Full text Link to item Cite

Multiparametric Prostate MR Imaging: Impact on Clinical Staging and Decision Making.

Journal Article Radiol Clin North Am · March 2018 Meaningful changes to the approach of prostate cancer staging and management have been made over the past decade with increasing demand for high-quality multiparametric MR imaging (mpMRI) of the prostate. This article focuses on the evolving paradigm of pr ... Full text Link to item Cite

Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease Progression.

Journal Article Eur Urol · March 2018 BACKGROUND: Global disparities in prostate cancer (PCa) incidence highlight the urgent need to identify genomic abnormalities in prostate tumors in different ethnic populations including Asian men. OBJECTIVE: To systematically explore the genomic complexit ... Full text Link to item Cite

Serum neuroendocrine (NE) markers and clinical characteristics of treatment-emergent small cell neuroendocrine prostate cancer (t-SCNC) in men with metastatic castration resistant prostate cancer (mCRPC): Data from the West Coast Prostate Cancer Dream Team.

Conference Journal of Clinical Oncology · February 20, 2018 278 Background: Detection of t-SCNC in mCRPC patients relies primarily on histopathologic evaluation (Histo) of a metastatic tumor biopsy (bx), likely leading to underdiagnosis. The clinical features of t-SCNC and the diagnostic ... Full text Cite

Luminal and basal subtyping of metastatic castration-resistant prostate cancer (mCRPC) and its clinical implications.

Conference Journal of Clinical Oncology · February 20, 2018 197 Background: The PAM50 gene expression classifier (PAM50) identifies luminal and basal subtypes and predicts response to androgen deprivation therapy in localized prostate cancer. The clinical utility of using PAM50 to molecul ... Full text Cite

Focal Therapy Eligibility Determined by Magnetic Resonance Imaging/Ultrasound Fusion Biopsy.

Journal Article J Urol · February 2018 PURPOSE: We assessed focal therapy eligibility in men who underwent multiparametric magnetic resonance imaging and targeted biopsy with correlation to whole mount histology after radical prostatectomy. MATERIALS AND METHODS: Subjects were selected from amo ... Full text Link to item Cite

Value of Tracking Biopsy in Men Undergoing Active Surveillance of Prostate Cancer.

Journal Article J Urol · January 2018 PURPOSE: We compared the upgrading rate obtained by resampling precise spots of prostate cancer (tracking biopsy) vs conventional systematic resampling during followup of men on active surveillance. MATERIALS AND METHODS: From 2009 to 2017 in 352 men prost ... Full text Link to item Cite

Risk Stratification Among Men With Prostate Imaging Reporting and Data System version 2 Category 3 Transition Zone Lesions: Is Biopsy Always Necessary?

Journal Article AJR Am J Roentgenol · December 2017 OBJECTIVE: The objective of our study was to determine the clinical and MRI characteristics of clinically significant prostate cancer (PCA) (Gleason score ≥ 3 + 4) in men with Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) category 3 tran ... Full text Link to item Cite

Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis.

Journal Article Oncogene · November 9, 2017 Current therapeutic regimens for prostate cancer focus on targeting androgen receptor (AR) signaling. However, the AR is a key factor in luminal epithelium differentiation and was shown to have a role as a tumor suppressor. Thus, its inhibition may activat ... Full text Link to item Cite

Patient selection for prostate focal therapy in the era of active surveillance: an International Delphi Consensus Project.

Journal Article Prostate Cancer Prostatic Dis · September 2017 BACKGROUND: Whole-gland extirpation or irradiation is considered the gold standard for curative oncological treatment for localized prostate cancer, but is often associated with sexual and urinary impairment that adversely affects quality of life. This has ... Full text Link to item Cite

Real-Time Transferrin-Based PET Detects MYC-Positive Prostate Cancer.

Journal Article Mol Cancer Res · September 2017 Noninvasive biomarkers that detect the activity of important oncogenic drivers could significantly improve cancer diagnosis and management of treatment. The goal of this study was to determine whether 68Ga-citrate (which avidly binds to circulating transfe ... Full text Link to item Cite

FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.

Journal Article Mod Pathol · September 2017 The median survival of patients with small cell neuroendocrine carcinoma is significantly shorter than that of patients with classic acinar-type adenocarcinoma. Small cell neuroendocrine carcinoma is traditionally diagnosed based on histologic features bec ... Full text Link to item Cite

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.

Journal Article Nat Med · September 2017 The bromodomain and extraterminal (BET) family of proteins comprises four members-BRD2, BRD3, BRD4 and the testis-specific isoform BRDT-that largely function as transcriptional coactivators and play critical roles in various cellular processes, including t ... Full text Link to item Cite

Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer.

Journal Article Sci Signal · August 15, 2017 Androgen deprivation therapy (ADT) targeting the androgen receptor (AR) is a standard therapeutic regimen for treating prostate cancer. However, most tumors progress to metastatic castration-resistant prostate cancer after ADT. We identified the type 1, 2, ... Full text Link to item Cite

CT-Guided Bone Biopsies in Metastatic Castration-Resistant Prostate Cancer: Factors Predictive of Maximum Tumor Yield.

Journal Article J Vasc Interv Radiol · August 2017 PURPOSE: To evaluate the success rate of CT-guided bone biopsies in metastatic castration-resistant prostate cancer (mCRPC) and to investigate associated technical, imaging, and clinical parameters affecting diagnostic yields. MATERIALS AND METHODS: Eighty ... Full text Link to item Cite

UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression.

Journal Article BMC Cancer · July 3, 2017 BACKGROUND: Uridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15 ... Full text Link to item Cite

Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer.

Journal Article Clin Cancer Res · July 1, 2017 Purpose: Deregulation or mutation of the EZH2 gene causes various tumors, including clear cell renal cell carcinoma (ccRCC). Although several splice variants of EZH2 have been identified, little is known about how EZH2 splicing is regulated or the contribu ... Full text Link to item Cite

Multiregional Radiogenomic Assessment of Prostate Microenvironments with Multiparametric MR Imaging and DNA Whole-Exome Sequencing of Prostate Glands with Adenocarcinoma.

Journal Article Radiology · July 2017 Purpose To assess the underlying genomic variation of prostate gland microenvironments of patients with prostate adenocarcinoma in the context of colocalized multiparametric magnetic resonance (MR) imaging and histopathologic assessment of normal and abnor ... Full text Link to item Cite

Establishing the distribution of satellite lesions in intermediate- and high-risk prostate cancer: implications for focused radiotherapy.

Journal Article Prostate Cancer Prostatic Dis · June 2017 BACKGROUND: In focused radiotherapy for prostate cancer (PC), a full dose of radiation is delivered to the index lesion while reduced dose is delivered to the remaining prostate to reduce morbidity. As PC is commonly multifocal, we investigated whether bas ... Full text Link to item Cite

Adrenal Teratoma: a Case Series and Review of the Literature.

Journal Article Endocr Pathol · June 2017 Adrenal teratomas are rare neoplasms and there is limited data on their surgical outcomes and long-term prognosis. We aimed to review our institutional experience and compare this to the existing literature on adrenal teratomas in adults and children. An i ... Full text Link to item Cite

Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth.

Journal Article Oncogene · March 2, 2017 Protein arginine methyltransferase 5 (PRMT5) is an emerging epigenetic enzyme that mainly represses transcription of target genes via symmetric dimethylation of arginine residues on histones H4R3, H3R8 and H2AR3. Accumulating evidence suggests that PRMT5 m ... Full text Link to item Cite

Targeted Biopsy to Detect Gleason Score Upgrading during Active Surveillance for Men with Low versus Intermediate Risk Prostate Cancer.

Journal Article J Urol · March 2017 PURPOSE: We sought to determine the rate of upgrading to Gleason score 4 + 3 or greater using targeted biopsy for diagnosis and monitoring in men undergoing active surveillance of prostate cancer. MATERIALS AND METHODS: Study subjects comprised all 259 men ... Full text Link to item Cite

Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer.

Journal Article Clin Cancer Res · February 15, 2017 Purpose: To determine whether MRI/ultrasound (MRI/US) fusion biopsy facilitates longitudinal resampling of the same clonal focus of prostate cancer and to determine whether high-grade cancers can evolve from low-grade clones.Experimental Design: All men on ... Full text Link to item Cite

Magnetic Resonance Imaging Underestimation of Prostate Cancer Geometry: Use of Patient Specific Molds to Correlate Images with Whole Mount Pathology.

Journal Article J Urol · February 2017 PURPOSE: We evaluated the accuracy of magnetic resonance imaging in determining the size and shape of localized prostate cancer. MATERIALS AND METHODS: The subjects were 114 men who underwent multiparametric magnetic resonance imaging before radical prosta ... Full text Link to item Cite

Histologic Spetrum of Metastatic Castration-Resistant Prostate Cancer

Conference LABORATORY INVESTIGATION · February 1, 2017 Link to item Cite

Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6.

Journal Article Cancer Lett · January 1, 2017 It has been suggested that ETV6 serves as a tumor suppressor; however, its molecular regulation and cellular functions remain unclear. We used prostate cancer as a model system and demonstrated a molecular mechanism in which ETV6 can be regulated by epider ... Full text Link to item Cite

Molecular Signature to Risk-Stratify Prostate Cancer of Intermediate Risk.

Journal Article Clin Cancer Res · January 1, 2017 A new 30-gene signature has been described that separates prostate cancers of Gleason score ≤6 from those of Gleason score ≥8. It provides independent prognostic information for prostate cancers of intermediate risk (Gleason score of 7), which has the pote ... Full text Open Access Link to item Cite

Potential therapeutic effect of epigenetic therapy on treatment-induced neuroendocrine prostate cancer.

Journal Article Asian J Androl · 2017 Although adenocarcinomas of the prostate are relatively indolent, some patients with advanced adenocarcinomas show recurrence of treatment-induced neuroendocrine prostate cancer, which is highly aggressive and lethal. Detailed biological features of treatm ... Full text Link to item Cite

Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.

Journal Article Cell Rep · December 6, 2016 Inflammation is a risk factor for prostate cancer, but the mechanisms by which inflammation increases that risk are poorly understood. Here, we demonstrate that low expression of CD38 identifies a progenitor-like subset of luminal cells in the human prosta ... Full text Link to item Cite

Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis.

Journal Article J Biol Chem · December 2, 2016 Although the differentiation of oncogenically transformed basal progenitor cells is one of the key steps in prostate tumorigenesis, the mechanisms mediating this cellular process are still largely unknown. Here we demonstrate that an expanded p63+ and CK5+ ... Full text Link to item Cite

Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation-Supported West Coast Prostate Cancer Dream Team.

Journal Article Eur Urol Focus · December 2016 The Stand Up 2 Cancer/Prostate Cancer Foundation-funded West Coast Dream Team project is a prospective multi-institutional study focused on acquiring metastatic castration-resistant prostate cancer (mCRPC) biopsy tissue at the time of resistance to abirate ... Full text Link to item Cite

Biased Expression of the FOXP3Δ3 Isoform in Aggressive Bladder Cancer Mediates Differentiation and Cisplatin Chemotherapy Resistance.

Journal Article Clin Cancer Res · November 1, 2016 PURPOSE: The transcriptional regulation mediating cancer cell differentiation into distinct molecular subtypes and modulating sensitivity to existing treatments is an enticing therapeutic target. Our objective was to characterize the ability of the forkhea ... Full text Link to item Cite

Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy.

Journal Article Int J Oncol · November 2016 Near-infrared fluorescence (NIRF) imaging is a novel imaging modality that allows for detection and real‑time monitoring of various pathophysiological states. IR-780 iodide has been used as an ideal platform to construct theranostic agents for cancer imagi ... Full text Link to item Cite

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.

Journal Article Proc Natl Acad Sci U S A · October 18, 2016 Metastatic castration-resistant prostate cancer (CRPC) is the primary cause of prostate cancer-specific mortality. Defining new mechanisms that can predict recurrence and drive lethal CRPC is critical. Here, we demonstrate that localized high-risk prostate ... Full text Link to item Cite

Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer.

Journal Article Cell · August 11, 2016 We used clinical tissue from lethal metastatic castration-resistant prostate cancer (CRPC) patients obtained at rapid autopsy to evaluate diverse genomic, transcriptomic, and phosphoproteomic datasets for pathway analysis. Using Tied Diffusion through Inte ... Full text Link to item Cite

Focal Laser Ablation of Prostate Cancer: Phase I Clinical Trial.

Journal Article J Urol · July 2016 PURPOSE: Focal laser ablation is an investigational technique to treat prostate cancer in a region confined manner via coagulative necrosis. This phase I trial primarily examines the safety of transrectal magnetic resonance imaging guided (in-bore) focal l ... Full text Link to item Cite

In-bore magnetic resonance-guided transrectal biopsy for the detection of clinically significant prostate cancer.

Journal Article Abdom Radiol (NY) · May 2016 PURPOSE: To determine the safety and efficacy of in-bore magnetic resonance-guided prostate biopsy (MRGB) for detection of clinically significant disease (CSD) in untreated men with known or suspected prostate cancer (PCa). METHODS: 512 patients underwent ... Full text Link to item Cite

Serial Magnetic Resonance Imaging in Active Surveillance of Prostate Cancer: Incremental Value.

Journal Article J Urol · May 2016 PURPOSE: We assessed whether changes in serial multiparametric magnetic resonance imaging can help predict the pathological progression of prostate cancer in men on active surveillance. MATERIALS AND METHODS: A retrospective cohort study was conducted of 4 ... Full text Link to item Cite

Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay.

Journal Article Proc Natl Acad Sci U S A · April 19, 2016 The cell of origin for prostate cancer remains a subject of debate. Genetically engineered mouse models have demonstrated that both basal and luminal cells can serve as cells of origin for prostate cancer. Using a human prostate regeneration and transforma ... Full text Link to item Cite

Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay

Journal Article Proceedings of the National Academy of Sciences of USA · April 19, 2016 Link to item Cite

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.

Journal Article Cancer Cell · April 11, 2016 MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated A ... Full text Link to item Cite

The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.

Journal Article Mol Cancer Res · April 2016 UNLABELLED: While prostatic adenocarcinomas are relatively indolent, some patients with advanced adenocarcinomas recur with small cell neuroendocrine carcinoma which is highly aggressive and lethal. Because glycolysis is a feature of malignancy and the deg ... Full text Link to item Cite

All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy.

Journal Article BMC Complement Altern Med · March 31, 2016 BACKGROUND: Radiotherapy is of critical importance in the treatment of breast cancer. However, not all patients derive therapeutic benefit and some breast cancers are resistant to the treatment, and are thus evidenced with prospective distant metastatic sp ... Full text Link to item Cite

Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: The role of systematic and targeted biopsies.

Journal Article Cancer · March 15, 2016 BACKGROUND: The current study was conducted to evaluate the performance of magnetic resonance (MR)-ultrasound-guided fusion biopsy in diagnosing clinically significant prostate cancer (csCaP). METHODS: A total of 1042 men underwent multiparametric MR imagi ... Full text Link to item Cite

Functional screen identifies kinases driving prostate cancer visceral and bone metastasis.

Journal Article Proc Natl Acad Sci U S A · January 12, 2016 Mutationally activated kinases play an important role in the progression and metastasis of many cancers. Despite numerous oncogenic alterations implicated in metastatic prostate cancer, mutations of kinases are rare. Several lines of evidence suggest that ... Full text Link to item Cite

Redefining the Autonomic Nerve Distribution of the Bladder Using 3-Dimensional Image Reconstruction.

Journal Article J Urol · December 2015 PURPOSE: We sought to create a 3-dimensional reconstruction of the autonomic nervous tissue innervating the bladder using male and female cadaver histopathology. MATERIALS AND METHODS: We obtained bladder tissue from a male and a female cadaver. Axial cros ... Full text Link to item Cite

Prostate diffusion imaging with distortion correction.

Journal Article Magn Reson Imaging · November 2015 PURPOSE: Diffusion imaging in the prostate is susceptible to distortion from B0 inhomogeneity. Distortion correction in prostate imaging is not routinely performed, resulting in diffusion images without accurate localization of tumors. We performed and eva ... Full text Link to item Cite

Exploring Glycan Markers for Immunotyping and Precision-targeting of Breast Circulating Tumor Cells.

Journal Article Arch Med Res · November 2015 BACKGROUND AND AIMS: Recognition of abnormal glycosylation in virtually every cancer type has raised great interest in exploration of the tumor glycome for biomarker discovery. Identifying glycan markers of circulating tumor cells (CTCs) represents a new d ... Full text Link to item Cite

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

Journal Article Mol Cell · September 17, 2015 The ERG gene is fused to TMPRSS2 in approximately 50% of prostate cancers (PrCa), resulting in its overexpression. However, whether this is the sole mechanism underlying ERG elevation in PrCa is currently unclear. Here we report that ERG ubiquitination and ... Full text Link to item Cite

Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer.

Journal Article Nat Commun · September 16, 2015 Glucocorticoids (GCs) have been widely used as coadjuvants in the treatment of solid tumours, but GC treatment may be associated with poor pharmacotherapeutic response or prognosis. The genomic action of GC in these tumours is largely unknown. Here we find ... Full text Link to item Cite

Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases.

Journal Article Cancer · September 15, 2015 BACKGROUND: Although enumeration of circulating tumor cells (CTCs) has shown some clinical value, the pool of CTCs contains a mixture of cells that contains additional information that can be extracted. The authors subclassified CTCs by shape features focu ... Full text Link to item Cite

Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells.

Journal Article Oncotarget · September 15, 2015 Human cancers are heterogeneous containing stem-like cancer cells operationally defined as cancer stem cells (CSCs) that possess great tumor-initiating and long-term tumor-propagating properties. In this study, we systematically dissect the phenotypic, fun ... Full text Link to item Cite

Increased androgen receptor gene copy number is associated with TMPRSS2-ERG rearrangement in prostatic small cell carcinoma.

Journal Article Mol Carcinog · September 2015 Small cell carcinoma of the prostate (PSCC) is a highly aggressive malignancy that often develops in patients previously treated with hormonal therapy for metastatic prostatic acinar adenocarcinoma. The TMPRSS2-ERG gene rearrangement is highly specific for ... Full text Link to item Cite

EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1.

Journal Article Cancer Res · August 1, 2015 Dysregulation of the EGFR signaling axis enhances bone metastases in many solid cancers. However, the relevant downstream effector signals in this axis are unclear. miR-1 was recently shown to function as a tumor suppressor in prostate cancer cells, where ... Full text Link to item Cite

Functional expression of sodium-glucose transporters in cancer.

Journal Article Proc Natl Acad Sci U S A · July 28, 2015 Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate the importance of another glucose import system, the sodium-dependent glu ... Full text Link to item Cite

Patients with Biopsy Gleason 9 and 10 Prostate Cancer Have Significantly Worse Outcomes Compared to Patients with Gleason 8 Disease.

Journal Article J Urol · July 2015 PURPOSE: We examined differences in outcome in patients with biopsy Gleason score 8 vs 9-10 who received definitive local therapy. MATERIALS AND METHODS: Using an institutional database we identified a cohort of 847 patients with biopsy Gleason 8-10 diseas ... Full text Link to item Cite

Characteristics of Detected and Missed Prostate Cancer Foci on 3-T Multiparametric MRI Using an Endorectal Coil Correlated With Whole-Mount Thin-Section Histopathology.

Journal Article AJR Am J Roentgenol · July 2015 OBJECTIVE: The objective of this study was to determine the characteristics of prostate cancer foci missed on 3-T multiparametric MRI performed with an endorectal coil. MATERIALS AND METHODS: The MRI examinations of 122 patients who underwent 3-T multipara ... Full text Link to item Cite

Elevated circulating tissue inhibitor of metalloproteinase 1 (TIMP-1) levels are associated with neuroendocrine differentiation in castration resistant prostate cancer.

Journal Article Prostate · May 2015 BACKGROUND: Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a 28.5 kDa secreted glycoprotein that inhibits matrix metalloproteinase (MMP) activity. Our group has previously shown that elevated plasma TIMP-1 levels predict poor survival in metastatic ca ... Full text Link to item Cite

Loss of MyD88 leads to more aggressive TRAMP prostate cancer and influences tumor infiltrating lymphocytes.

Journal Article Prostate · April 1, 2015 BACKGROUND: The influence of pattern recognition receptor (PRR) signaling in the prostate tumor microenvironment remains unclear. Although there may be a role for PRR agonists as adjuvants to therapy, prior evidence suggests tumor promoting as well as tumo ... Full text Link to item Cite

CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy.

Journal Article Cancer Res · March 15, 2015 Growing evidence suggests that tumor-associated macrophages (TAM) promote cancer progression and therapeutic resistance by enhancing angiogenesis, matrix-remodeling, and immunosuppression. In this study, prostate cancer under androgen blockade therapy (ABT ... Full text Link to item Cite

Multifocality and prostate cancer detection by multiparametric magnetic resonance imaging: correlation with whole-mount histopathology.

Journal Article Eur Urol · March 2015 BACKGROUND: Multiparametric magnetic resonance imaging (mp-MRI) is increasingly used in prostate cancer (CaP). Understanding the limitations of tumor detection, particularly in multifocal disease, is important in its clinical application. OBJECTIVE: To det ... Full text Link to item Cite

p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma.

Journal Article Mol Cancer Res · March 2015 UNLABELLED: Prostatic small cell neuroendocrine carcinoma (SCNC) is a rare but aggressive form of prostate cancer that is negative for androgen receptor (AR) and not responsive to hormonal therapy. The molecular etiology of this prostate cancer variant is ... Full text Link to item Cite

Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension.

Journal Article Prostate Cancer Prostatic Dis · March 2015 BACKGROUND: Standard magnetic resonance imaging (MRI) of the prostate lacks sensitivity in the diagnosis and staging of prostate cancer (PCa). To improve the operating characteristics of prostate MRI in the detection and characterization of PCa, we develop ... Full text Link to item Cite

Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer.

Journal Article EMBO J · February 12, 2015 Human transcription factors recognize specific DNA sequence motifs to regulate transcription. It is unknown whether a single transcription factor is able to bind to distinctly different motifs on chromatin, and if so, what determines the usage of specific ... Full text Link to item Cite

MRI-Derived Restriction Spectrum Imaging Cellularity Index is Associated with High Grade Prostate Cancer on Radical Prostatectomy Specimens.

Journal Article Front Oncol · 2015 PURPOSE: We evaluate a novel magnetic resonance imaging (MRI) technique to improve detection of aggressive prostate cancer (PCa). MATERIALS AND METHODS: We performed a retrospective analysis of pre-surgical prostate MRI scans using an advanced diffusion-we ... Full text Link to item Cite

Neuroendocrine differentiation in prostate cancer: a mechanism of radioresistance and treatment failure.

Journal Article Front Oncol · 2015 Neuroendocrine differentiation (NED) in prostate cancer is a well-recognized phenotypic change by which prostate cancer cells transdifferentiate into neuroendocrine-like (NE-like) cells. NE-like cells lack the expression of androgen receptor and prostate s ... Full text Link to item Cite

Multiparametric magnetic resonance imaging for prostate cancer improves Gleason score assessment in favorable risk prostate cancer.

Journal Article Pract Radiat Oncol · 2015 PURPOSE: Magnetic resonance imaging (MRI) guidance may improve the accuracy of Gleason score (GS) determination by directing the biopsy to regions of interest (ROI) that are likely to harbor high-grade prostate cancer (CaP). The aim of this study was to de ... Full text Link to item Cite

Carbohydrate Microarrays Identify Blood Group Precursor Cryptic Epitopes as Potential Immunological Targets of Breast Cancer.

Journal Article J Immunol Res · 2015 Using carbohydrate microarrays, we explored potential natural ligands of antitumor monoclonal antibody HAE3. This antibody was raised against a murine mammary tumor antigen but was found to cross-react with a number of human epithelial tumors in tissues. O ... Full text Link to item Cite

Magnetic resonance imaging-ultrasound fusion biopsy for prediction of final prostate pathology.

Journal Article J Urol · November 2014 PURPOSE: We explored the impact of magnetic resonance imaging-ultrasound fusion prostate biopsy on the prediction of final surgical pathology. MATERIALS AND METHODS: A total of 54 consecutive men undergoing radical prostatectomy at UCLA after fusion biopsy ... Full text Link to item Cite

Initial experience with electronic tracking of specific tumor sites in men undergoing active surveillance of prostate cancer.

Journal Article Urol Oncol · October 2014 OBJECTIVES: Targeted biopsy, using magnetic resonance (MR)-ultrasound (US) fusion, may allow tracking of specific cancer sites in the prostate. We aimed to evaluate the initial use of the technique to follow tumor sites in men on active surveillance of pro ... Full text Link to item Cite

PIP5K1α inhibition as a therapeutic strategy for prostate cancer.

Journal Article Proc Natl Acad Sci U S A · September 2, 2014 Full text Link to item Cite

Targeted prostate biopsy in select men for active surveillance: do the Epstein criteria still apply?

Journal Article J Urol · August 2014 PURPOSE: Established in 1994, the Epstein histological criteria (Gleason score 6 or less, 2 or fewer cores positive and 50% or less of any core) have been widely used to select men for active surveillance. However, with the advent of targeted biopsy, which ... Full text Link to item Cite

Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers.

Journal Article Urol Oncol · July 2014 Widespread use of L-type calcium channel blockers for treating hypertension has led to multiple epidemiologic studies to assess the risk of prostate cancer incidence. These studies revealed a reverse correlation between the likelihood of prostate cancer ri ... Full text Link to item Cite

Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance.

Journal Article Oncotarget · June 15, 2014 Activation of EGFR signaling pathway leads to prostate cancer bone metastasis; however, therapies targeting EGFR have demonstrated limited effectiveness and led to drug resistance. miR-203 levels are down-regulated in clinical samples of primary prostate c ... Full text Link to item Cite

Aggressive variants of castration-resistant prostate cancer.

Journal Article Clin Cancer Res · June 1, 2014 A subset of patients with advanced castration-resistant prostate cancer may eventually evolve into an androgen receptor (AR)-independent phenotype, with a clinical picture associated with the development of rapidly progressive disease involving visceral si ... Full text Link to item Cite

Poor prognosis and advanced clinicopathological features of clear cell renal cell carcinoma (ccRCC) are associated with cytoplasmic subcellular localisation of Hypoxia inducible factor-2α.

Journal Article Eur J Cancer · May 2014 BACKGROUND: Pre-clinical studies have implicated hypoxia inducible factor (HIF)-2α as an important oncogene for clear cell renal cell carcinoma (ccRCC). Generally considered to act as a nuclear transcription factor, a recent study has also implicated HIF-2 ... Full text Link to item Cite

Value of targeted prostate biopsy using magnetic resonance-ultrasound fusion in men with prior negative biopsy and elevated prostate-specific antigen.

Journal Article Eur Urol · April 2014 BACKGROUND: Conventional biopsy fails to detect the presence of some prostate cancers (PCas). Men with a prior negative biopsy but persistently elevated prostate-specific antigen (PSA) pose a diagnostic dilemma, as some harbor elusive cancer. OBJECTIVE: To ... Full text Link to item Cite

Intrarenal and extrarenal autonomic nervous system redefined.

Journal Article J Urol · April 2014 PURPOSE: The autonomic nervous supply to the kidneys is involved in the development of several diseases including hypertension. The neural distribution at the segmental vessels and intrarenal vasculature has not been well characterized. Thus, we evaluated ... Full text Link to item Cite

The role of magnetic resonance imaging in delineating clinically significant prostate cancer.

Journal Article Urology · February 2014 OBJECTIVE: To determine whether multiparametric magnetic resonance imaging might improve the identification of patients with higher risk disease at diagnosis and thereby reduce the incidence of undergrading or understaging. METHODS: We retrospectively revi ... Full text Link to item Cite

Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors.

Journal Article J Biol Chem · January 17, 2014 Deregulation of androgen receptor (AR) splice variants has been implicated to play a role in prostate cancer development and progression. To understand their functions in prostate, we established a transgenic mouse model (AR3Tg) with targeted expression of ... Full text Link to item Cite

Erk/MAP kinase signaling pathway and neuroendocrine differentiation of non-small-cell lung cancer.

Journal Article J Thorac Oncol · January 2014 INTRODUCTION: Almost all small-cell lung cancers (SCLC) and carcinoid tumors express neuroendocrine differentiation (NED), and 10% to 20% of non-small-cell lung cancers (NSCLC) are associated with NED. Although distinct clinical features and histology of S ... Full text Link to item Cite

Targeted prostate biopsy: value of multiparametric magnetic resonance imaging in detection of localized cancer.

Journal Article Asian J Androl · 2014 Prostate cancer is the second most common cancer in men, with 1.1 million new cases worldwide reported by the World Health Organization in one recent year. Transrectal ultrasound (TRUS)-guided biopsy has been used for the diagnosis of prostate cancer for o ... Full text Link to item Cite

Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation.

Journal Article Asian J Androl · 2014 Most prostate cancers (PCas) are classified as acinar type (conventional) adenocarcinoma which are composed of tumor cells with luminal differentiation including the expression of androgen receptor (AR) and prostate-specific antigen (PSA). There are also s ... Full text Link to item Cite

RARP in high-risk prostate cancer: use of multi-parametric MRI and nerve sparing techniques.

Journal Article Asian J Androl · 2014 To examine the outcomes of patients with high-risk prostate cancer (PCa) treated by robot-assisted radical prostatectomy (RARP) and evaluate the value of multi-parametric magnetic resonance imaging (MRI) in estimating tumor stage, extracapsular extension, ... Full text Link to item Cite

A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds.

Journal Article Am J Clin Exp Urol · 2014 We have developed a system for evaluating magnetic resonance imaging of prostate cancer, using patient-specific 3D printed molds to facilitate MR-histology correlation. Prior to radical prostatectomy a patient receives a multiparametric MRI, which an exper ... Link to item Cite

PIP5K1α inhibition as a therapeutic strategy for prostate cancer

Journal Article Proceedings of the National Academy of Sciences of USA · 2014 Cite

Fasting times in serum PSA assay.

Journal Article Asian J Androl · 2014 Full text Link to item Cite

Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion.

Journal Article Asian J Androl · 2014 SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer (PCa) tissues and cells and to preliminarily investigate the role of SETDB1 in prostate tumorigenesis ... Full text Link to item Cite

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells.

Journal Article Proc Natl Acad Sci U S A · December 10, 2013 The relationship between the cells that initiate cancer and the cancer stem-like cells that propagate tumors has been poorly defined. In a human prostate tissue transformation model, basal cells expressing the oncogenes Myc and myristoylated AKT can initia ... Full text Link to item Cite

Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.

Journal Article Proc Natl Acad Sci U S A · December 3, 2013 In prostate cancer, multiple metastases from the same patient share similar copy number, mutational status, erythroblast transformation specific (ETS) rearrangements, and methylation patterns supporting their clonal origins. Whether actionable targets such ... Full text Link to item Cite

NanoVelcro Chip for CTC enumeration in prostate cancer patients.

Journal Article Methods · December 1, 2013 Circulating tumor cells (CTCs) are one of the most crucial topics in rare cell biology and have become the focus of a significant and emerging area of cancer research. While CTC enumeration is a valid biomarker in prostate cancer, the current FDA-approved ... Full text Link to item Cite

Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer.

Journal Article J Urol · December 2013 PURPOSE: To understand the role of MALAT-1 in prostate cancer we evaluated its expression in prostate cancer tissues and cell lines. We also studied the therapeutic effects of MALAT-1 silencing on castration resistant prostate cancer cells in vitro and in  ... Full text Link to item Cite

Frequent TMPRSS2-ERG rearrangement in prostatic small cell carcinoma detected by fluorescence in situ hybridization: the superiority of fluorescence in situ hybridization over ERG immunohistochemistry.

Journal Article Hum Pathol · October 2013 Small cell carcinoma of the prostate is both morphologically and immunohistochemically similar to small cell carcinoma of other organs such as the urinary bladder or lung. TMPRSS2-ERG gene fusion appears to be a highly specific alteration in prostatic carc ... Full text Link to item Cite

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.

Journal Article Am J Surg Pathol · October 2013 The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of ... Full text Link to item Cite

The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters.

Journal Article Am J Surg Pathol · October 2013 The International Society of Urological Pathology 2012 Consensus Conference made recommendations regarding classification, prognostic factors, staging, and immunohistochemical and molecular assessment of adult renal tumors. Issues relating to prognostic fa ... Full text Link to item Cite

Renal tumors: diagnostic and prognostic biomarkers.

Journal Article Am J Surg Pathol · October 2013 The International Society of Urological Pathology convened a consensus conference on renal cancer, preceded by an online survey, to address issues relating to the diagnosis and reporting of renal neoplasia. In this report, the role of biomarkers in the dia ... Full text Link to item Cite

Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations.

Journal Article Am J Surg Pathol · October 2013 The International Society of Urologic Pathology 2012 Consensus Conference on renal cancer, through working group 3, focused on the issues of staging and specimen handling of renal tumors. The conference was preceded by an online survey of the International ... Full text Link to item Cite

Enrichment of putative prostate cancer stem cells after androgen deprivation: upregulation of pluripotency transactivators concurs with resistance to androgen deprivation in LNCaP cell lines.

Journal Article Prostate · September 2013 BACKGROUND: Prostate cancer stem cells (PCSC) offer theoretical explanations to many clinical and biological behaviors of the disease in human. In contrast to approaches of using side populations and cell-surface markers to isolate and characterize the put ... Full text Link to item Cite

Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer.

Journal Article Eur J Cancer · September 2013 Examining plasma RNA is an emerging non-invasive diagnosis technique. However, whether tumour-derived long non-coding RNAs (lncRNAs) in plasma can be used as a novel approach to detect human prostate cancer (PCa) has not yet been established. The study was ... Full text Link to item Cite

The molecular basis for ethnic variation and histological subtype differences in prostate cancer.

Journal Article Sci China Life Sci · September 2013 Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China. Rapidly evolving technology in molecular biology such as hig ... Full text Link to item Cite

Fine-tuning robot-assisted radical prostatectomy planning with MRI.

Journal Article Urol Oncol · August 2013 OBJECTIVES: Robot-assisted radical prostatectomy (RARP) has now become the most common surgical treatment option for prostate cancer (CaP). Clinicopathologic data (i.e., biopsy, digital rectal exam, prostate specific antigen level) and patient-specific fac ... Full text Link to item Cite

Molecular pathology of prostate cancer revealed by next-generation sequencing: opportunities for genome-based personalized therapy.

Journal Article Curr Opin Urol · May 2013 PURPOSE OF REVIEW: This article reviews recently identified genomic mutations in prostate cancer. RECENT FINDINGS: Advanced sequencing technologies have made it possible to obtain large amounts of data on genomes and transcriptomes of cancers. Such technol ... Full text Link to item Cite

Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.

Journal Article Cancer Res · May 1, 2013 Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue culture models are extremely useful in understanding the biology of prostate cancer, they cannot re ... Full text Link to item Cite

Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinoma.

Journal Article Cancer Res · February 15, 2013 Clear cell renal cell carcinomas (RCC), the major histologic subtype of RCC accounting for more than 80% of cases, are typified by biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. Although accumulation of hypoxia-inducible facto ... Full text Link to item Cite

Targeted biopsy in the detection of prostate cancer using an office based magnetic resonance ultrasound fusion device.

Journal Article J Urol · January 2013 PURPOSE: Targeted biopsy of lesions identified on magnetic resonance imaging may enhance the detection of clinically relevant prostate cancers. We evaluated prostate cancer detection rates in 171 consecutive men using magnetic resonance ultrasound fusion p ... Full text Link to item Cite

Recent development in the staging of bladder urothelial carcinoma

Journal Article Chinese Journal of Urology · 2013 Cite

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells

Journal Article Proceedings of the National Academy of Sciences of USA · 2013 Cite

Association between tumor-associated macrophage infiltration, high grade prostate cancer, and biochemical recurrence after radical prostatectomy.

Journal Article Am J Cancer Res · 2013 BACKGROUND: Tumor-associated macrophages (TAMs) are a key component of the inflammatory microenvironment. Their role in prostate cancer development and progression remains unclear. We examined whether the amount of TAMs in prostate cancer is: 1) higher tha ... Link to item Cite

Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling.

Journal Article Proc Natl Acad Sci U S A · December 11, 2012 Carcinomas most often result from the stepwise acquisition of genetic alterations within the epithelial compartment. The surrounding stroma can also play an important role in cancer initiation and progression. Given the rare frequencies of genetic events i ... Full text Link to item Cite

Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.

Journal Article Stem Cells · November 2012 The reproductive role of the fallopian tube is to transport the sperm and egg. The tube is positioned to act as a bridge between the ovary where the egg is released and the uterus where implantation occurs. Throughout reproductive years, the fallopian tube ... Full text Link to item Cite

Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling.

Journal Article Genes Dev · October 15, 2012 The cell surface protein Trop2 is expressed on immature stem/progenitor-like cells and is overexpressed in many epithelial cancers. However the biological function of Trop2 in tissue maintenance and tumorigenesis remains unclear. In this study, we demonstr ... Full text Link to item Cite

Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis.

Journal Article Endocr Relat Cancer · October 2012 Phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway plays a key role in the tumorigenesis of a variety of human cancers including ovarian cancer. However, inhibitors of this pathway such as Rad001 have not shown therapeutic efficacy as ... Full text Link to item Cite

Radical prostatectomy: value of prostate MRI in surgical planning.

Journal Article Abdom Imaging · August 2012 The introduction of serum prostate-specific antigen to the prostate cancer screening algorithm has led to an increase in prostate cancer diagnosis as well as a migration toward lower-stage cancer at the time of diagnosis. This stage migration has coincided ... Full text Link to item Cite

Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway.

Journal Article Endocr Relat Cancer · June 2012 Small cell neuroendocrine carcinoma (SCNC) of the prostate is a variant form of prostate cancer that occurs de novo or as a recurrent tumor in patients who received hormonal therapy for prostatic adenocarcinoma. It is composed of pure neuroendocrine (NE) t ... Full text Link to item Cite

Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells.

Journal Article Mol Cancer Ther · June 2012 PI3K/AKT/mTOR pathway plays a key role in the tumorigenesis of many human cancers including prostate cancer. However, inhibitors of this pathway, such as Rad001, have not shown therapeutic efficacy as a single agent. Through a high-throughput screen of 5,0 ... Full text Link to item Cite

The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration.

Journal Article Cell Stem Cell · May 4, 2012 Prostate cancer (PCa) is heterogeneous and contains both differentiated and undifferentiated tumor cells, but the relative functional contribution of these two cell populations remains unclear. Here we report distinct molecular, cellular, and tumor-propaga ... Full text Link to item Cite

Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.

Journal Article J Biol Chem · April 27, 2012 Protooncogene Ski was identified based on its ability to transform avian fibroblasts in vitro. In support of its oncogenic activity, SKI was found to be overexpressed in a variety of human cancers, although the exact molecular mechanism(s) responsible for ... Full text Link to item Cite

Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells.

Journal Article Cancer Res · April 1, 2012 PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies ... Full text Link to item Cite

Value of prostate MRI in determining appropriate candidates for active surveillance.

Conference Journal of Clinical Oncology · February 10, 2012 109 Background: The objective was to measure the added benefit of multi-parametric endorectal coil prostate MRI (eMRI) to traditional active (AS) criteria in delineating men with more advanced disease. Methods: ... Full text Cite

Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.

Journal Article Proc Natl Acad Sci U S A · January 31, 2012 Dominant mutations or DNA amplification of tyrosine kinases are rare among the oncogenic alterations implicated in prostate cancer. We demonstrate that castration-resistant prostate cancer (CRPC) in men exhibits increased tyrosine phosphorylation, raising ... Full text Link to item Cite

PC3 is a cell line characteristic of prostatic small cell carcinoma.

Journal Article Prostate · November 2011 BACKGROUND: The majority of the prostatic cancers are adenocarcinomas characterized by glandular formation and the expression of luminal differentiation markers androgen receptor (AR) and prostate-specific antigen (PSA). Most adenocarcinomas are indolent a ... Full text Link to item Cite

ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin.

Journal Article Mod Pathol · August 2011 Prostatic carcinoma is a heterogeneous disease with frequent multifocality and variability in morphology. Particularly, prostatic small cell carcinoma is a rare variant with aggressive behavior. Distinction between small cell carcinoma of the prostate and ... Full text Link to item Cite

Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth.

Journal Article Cancer Cell · June 14, 2011 Alteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant prostate cancer (CRPC). However, how PTEN loss is involved in CRPC development is not clear. Here, we show that castration-resistant growth is an intrinsic property of ... Full text Link to item Cite

High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not.

Journal Article Hum Pathol · June 2011 Enhancer of zeste homolog 2, the catalytic subunit of polycomb repressive complex 2, is a histone methyltransferase and plays an important role in cell proliferation and cell cycle regulation. It has been shown to be overexpressed in a number of malignant ... Full text Link to item Cite

SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein.

Journal Article J Biol Chem · May 27, 2011 Chromosomal translocations are a major source of genetic abnormalities causally linked to certain malignancies. Synovial sarcoma is an aggressive soft tissue tumor characterized by a chromosomal translocation between chromosome 18 and X, generating oncopro ... Full text Link to item Cite

Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal.

Journal Article Proc Natl Acad Sci U S A · May 10, 2011 The steroid hormone signaling axis is thought to play a central role in initiation and progression of many hormonally regulated epithelial tumors. It is unclear whether all cancer-initiating signals depend on an intact hormone receptor signaling machinery. ... Full text Link to item Cite

Purification and direct transformation of epithelial progenitor cells from primary human prostate.

Journal Article Nat Protoc · May 2011 Epithelial cell transformation has been demonstrated in numerous animal models for the study of solid tumor biology. However, little evidence exists for human epithelial cell transformation without previous immortalization via genetic influences such as SV ... Full text Link to item Cite

The landscape of EGFR pathways and personalized management of non-small-cell lung cancer.

Journal Article Future Oncol · April 2011 Two classes of anti-EGF receptor (EGFR) agents, monoclonal anti-EGFR antibodies and small-molecule EGFR tyrosine kinase inhibitors, have been used for the treatment of non-small-cell lung cancer (NSCLC). However, only a subset of patients will benefit from ... Full text Link to item Cite

Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy.

Journal Article PLoS One · March 7, 2011 Deregulation of the non-receptor tyrosine kinase ETK/BMX has been reported in several solid tumors. In this report, we demonstrated that ETK expression is progressively increased during bladder cancer progression. We found that down-regulation of ETK in bl ... Full text Link to item Cite

Invasive prostate carcinoma driven by c-Src and androgen receptor synergy.

Journal Article Cancer Res · February 1, 2011 Cellular Src (c-Src) integrates a large number of signal transduction pathways regulating cell division, migration, and other aspects of cell physiology. Mutations of Src kinase have not been described in human prostate cancer, but evidence for increased l ... Full text Link to item Cite

Thrombin expression in prostate: a novel finding.

Journal Article Cancer Invest · January 2011 INTRODUCTION: A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS: Detection of thrombin was performed using quantitative real-time PCR in fresh tissue an ... Full text Link to item Cite

Clinical application of a 3D ultrasound-guided prostate biopsy system.

Journal Article Urol Oncol · 2011 OBJECTIVES: Prostate biopsy (Bx) has for 3 decades been performed in a systematic, but blind fashion using 2D ultrasound (US). Herein is described the initial clinical evaluation of a 3D Bx tracking and targeting device (Artemis; Eigen, Grass Valley, CA). ... Full text Link to item Cite

Working group 2: T2 substaging and prostate cancer volume

Journal Article Modern Pathology · 2011 Cite

Working group 1: specimen handling

Conference Modern Pathology · 2011 Cite

Working group 4: seminal vesicles and lymph nodes

Journal Article Modern Pathology · 2011 Cite

Working group 5: surgical margins

Journal Article Modern Pathology · 2011 Cite

The oncogenic gene fusion TMPRSS2: ERG is not a diagnostic or prognostic marker for ovarian cancer.

Journal Article Int J Clin Exp Pathol · 2011 TMPRSS2:ERG is a gene fusion resulting from the chromosomal rearrangement of the androgen-regulated TMPRSS2 gene and the ETS transcription factor ERG, leading to the over-expression of the oncogenic molecule ERG. This gene rearrangement has been found in a ... Link to item Cite

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handling.

Journal Article Mod Pathol · January 2011 The 2009 International Society of Urological Pathology Consensus Conference in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to the handling and processing of radical pr ... Full text Link to item Cite

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume.

Journal Article Mod Pathol · January 2011 The 2009 International Society of Urological Pathology consensus conference in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to the substaging of pT2 prostate cancers ac ... Full text Link to item Cite

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes.

Journal Article Mod Pathol · January 2011 The 2009 International Society of Urological Pathology Consensus Conference in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to the infiltration of tumor into the semina ... Full text Link to item Cite

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 5: surgical margins.

Journal Article Mod Pathol · January 2011 The 2009 International Society of Urological Pathology Consensus Conference in Boston, made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to surgical margin assessment were coordina ... Full text Link to item Cite

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 3: extraprostatic extension, lymphovascular invasion and locally advanced disease.

Journal Article Mod Pathol · January 2011 The International Society of Urological Pathology Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues ... Full text Link to item Cite

Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration.

Journal Article Cancer Res · December 15, 2010 KLF4/GLKF4 is a transcription factor that can have divergent functions in different malignancies. The role of KLF4 in prostate cancer etiology remains unclear. We have recently reported that small double-stranded RNA can induce gene expression by targeting ... Full text Link to item Cite

Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance.

Journal Article Nat Med · December 2010 The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CRPC xenografts, we found a reproducible increase in N-cad ... Full text Link to item Cite

Platinum agents in prostate cancer

Chapter · December 1, 2010 The standard first-line treatment for metastatic castration-resistant prostate cancer (CRPC) is docetaxel chemotherapy. Platinum drugs, including cisplatin and carboplatin, when used as single agents and in combinations, have shown a moderate response in m ... Full text Cite

Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium.

Journal Article Proc Natl Acad Sci U S A · October 5, 2010 Epithelial-specific activation of the PI3-kinase pathway is the most common genetic alteration in type I endometrial cancer. In the majority of these tumors, PTEN expression is lost in the epithelium but maintained in tumor stroma. Currently reported PTEN ... Full text Link to item Cite

The influence of percutaneous nephrolithotomy on human systemic stress response, SIRS and renal function.

Journal Article Urol Res · October 2010 UNLABELLED: The objective of this study is to investigate the influences of percutaneous nephrolithotomy (PNL) and open surgery nephrolithotomy on the systemic stress response, SIRS and renal function. Forty patients with kidney calculi were enrolled in th ... Full text Link to item Cite

Neurosteroid transport by the organic solute transporter OSTα-OSTβ.

Journal Article J Neurochem · October 2010 A variety of steroids, including pregnenolone sulfate (PREGS) and dehydroepiandrosterone sulfate (DHEAS) are synthesized by specific brain cells, and are then delivered to their target sites, where they exert potent effects on neuronal excitability. The pr ... Full text Link to item Cite

A novel in vitro assay of tumor-initiating cells in xenograft prostate tumors.

Journal Article Prostate · September 15, 2010 BACKGROUND: The field of prostate cancer has been stymied by the difficulty of cultivating patient-derived samples in the laboratory. In order to help circumvent this challenge, we sought to develop an in vitro assay of human prostate cancer initiation emp ... Full text Link to item Cite

Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation.

Journal Article Mod Pathol · September 2010 Fibrolamellar carcinoma is a rare malignant primary liver neoplasm with characteristic histological features that typically arises in young patients without viral hepatitis or cirrhosis. Previous studies on this entity have been limited by small numbers of ... Full text Link to item Cite

CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis.

Journal Article Clin Cancer Res · August 1, 2010 PURPOSE: Chemokine receptor CXCR2 is associated with malignancy in several cancer models; however, the mechanisms involved in CXCR2-mediated tumor growth remain elusive. Here, we investigated the role of CXCR2 in human ovarian cancer. EXPERIMENTAL DESIGN: ... Full text Link to item Cite

Identification of a cell of origin for human prostate cancer.

Journal Article Science · July 30, 2010 Luminal cells are believed to be the cells of origin for human prostate cancer, because the disease is characterized by luminal cell expansion and the absence of basal cells. Yet functional studies addressing the origin of human prostate cancer have not pr ... Full text Link to item Cite

Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung.

Journal Article PLoS One · February 9, 2010 BACKGROUND: Non-small cell lung cancer (NSCLC) represents the majority (85%) of lung cancers and is comprised mainly of adenocarcinomas and squamous cell carcinomas (SCCs). The sequential pathogenesis of lung adenocarcinomas and SCCs occurs through dissimi ... Full text Link to item Cite

Basal epithelial stem cells are efficient targets for prostate cancer initiation.

Journal Article Proc Natl Acad Sci U S A · February 9, 2010 Prevailing theories suggest that luminal cells are the origin of prostate cancer because it is histologically defined by basal cell loss and malignant luminal cell expansion. We introduced a series of genetic alterations into prospectively identified popul ... Full text Link to item Cite

A seminal finding for prostate cancer?

Journal Article N Engl J Med · January 14, 2010 Full text Link to item Cite

Dysplastic ("in-situ") Lesions in multofocal renal oncocytomas (oncocytosis).

Journal Article Int J Clin Exp Pathol · June 18, 2009 Preneoplastic lesions for renal oncocytosis have not been well defined. We have attempted to identify the putative in-situ or dysplastic change in nephrectomy specimens with oncocytosis. Cases of multiple oncocytoma previously identified in radical nephrec ... Link to item Cite

Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancer.

Journal Article Prostate · May 15, 2009 BACKGROUND: Hormonal therapy is effective for advanced prostate cancer (PC) but the disease often recurs and becomes hormone-refractory. It is hypothesized that a subpopulation of cancer cells, that is, cancer stem cells (CSCs), survives hormonal therapy a ... Full text Link to item Cite

Small Cell Carcinoma of the Prostate

Internet Publication · April 20, 2009 Link to item Cite

Neuroendocrine differentiation in prostate cancer.

Journal Article Am J Transl Res · February 5, 2009 As any organ in the body human prostate is composed of many different types of cells as well as extracellular components. During prostate development, reciprocal cellular interactions between stromal cells and prostate epithelial cells ultimately lead to t ... Link to item Cite

CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers.

Journal Article Hum Pathol · February 2009 Small cell neuroendocrine carcinoma of the prostate is a rare variant of prostatic cancer that shares morphologic similarity with prostatic adenocarcinoma of Gleason 5 pattern. It has also been considered morphologically and immunohistochemically indisting ... Full text Link to item Cite

Ionizing radiation induces prostate cancer neuroendocrine differentiation through interplay of CREB and ATF2: implications for disease progression.

Journal Article Cancer Res · December 1, 2008 Radiation therapy is a first-line treatment for prostate cancer patients with localized tumors. Although some patients respond well to the treatment, approximately 10% of low-risk and up to 60% of high-risk prostate cancer patients experience recurrent tum ... Full text Link to item Cite

Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis.

Journal Article Neoplasia · September 2008 Aberrant stimulation of the canonical Wnt pathway induces mammary tumorigenesis in mice. It has been well documented that two types of tumors, adenocarcinoma and adenocarcinoma with squamous metaplasia, develop in these mutants. However, the molecular mech ... Full text Link to item Cite

Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors.

Journal Article Hum Pathol · August 2008 RNA-binding protein IMP3 is a KH-domain-containing protein and a member of the insulin-like growth factor messenger RNA-binding protein family. It is identical to K-homology protein overexpressed in cancer that was identified through screening for genes di ... Full text Link to item Cite

A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor.

Journal Article Int J Cancer · July 1, 2008 Prostate cancer is initially responsive to hormonal therapy, but cancers inevitably progress in an androgen-independent fashion with virtually all tumors evolving into more aggressive androgen refractory disease. Immunohistological comparisons of cyclooxyg ... Full text Link to item Cite

Schwannoma of the kidney.

Journal Article Mod Pathol · June 2008 Schwannomas of the kidney are rare, with only a few reported cases. We report three additional cases with immunohistochemical analysis. All three tumors were from females (aged 27, 35, and 59 years) and ranged from 4.8 to 8 cm in diameter. All of the patie ... Full text Link to item Cite

Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1.

Journal Article BMC Urol · April 23, 2008 BACKGROUND: Steroid hormones influence mitogenic signaling pathways, apoptosis, and cell cycle checkpoints, and it has long been known that incidence of bladder cancer (BC) in men is several times greater than in women, a difference that cannot be attribut ... Full text Link to item Cite

Small cell carcinoma of the prostate

Journal Article Diagnostic Histopathology · March 1, 2008 Small cell carcinoma of the prostate is a rare diagnostic entity that can be mistaken for high-grade conventional prostate carcinoma. It is important to recognize this tumor because of its poor prognosis and different treatment regimen from conventional pr ... Full text Cite

A phase 2 study of carboplatin plus docetaxel in men with metastatic hormone-refractory prostate cancer who are refractory to docetaxel.

Journal Article Cancer · February 1, 2008 BACKGROUND: Prostate cancer is the second leading cause of cancer mortality among men in the U.S. To the authors' knowledge, there is no proven, effective, second-line therapy for docetaxel-refractory disease. Recent data suggest that platinum salts may be ... Full text Link to item Cite

Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma.

Journal Article Expert Opin Med Diagn · February 2008 Thyroid transcription factor 1 (TTF-1) is a widely used biomarker in surgical pathology. Its nuclear staining is sensitive and specific for the diagnosis of primary pulmonary and thyroid adenocarcinoma as well as small cell carcinomas arising in many organ ... Full text Link to item Cite

Expression of claudin-7 in benign kidney and kidney tumors.

Journal Article Int J Clin Exp Pathol · January 1, 2008 Claudins, a family of tight junction-related transmembrane proteins, have been implicated in the pathogenesis of various human neoplasms. Expression of claudin-7 was increased in chromophobe renal cell carcinoma in a recent oligonucleotide microarray study ... Link to item Cite

Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid differentiation.

Journal Article Int J Clin Exp Pathol · January 1, 2008 We report a unique case of mucinous tubular and spindle cell carcinoma (MTSC) of the kidney with extensive sarcomatoid differentiation, multiple metastases, and a rapidly fatal clinical course. The patient presented with back pain and a pathologic L1 fract ... Link to item Cite

Soft tissue tumors of the prostate: a review.

Journal Article Anal Quant Cytol Histol · December 2007 Prostate cancer is a leading cause of cancer-related death in adult men. Some prostates that are suspected to be involved by prostatic adenocarcinoma or nodular prostatic hyperplasia through clinical examination and imaging studies proves on histologic exa ... Link to item Cite

Absence of Y chromosome in human placental site trophoblastic tumor.

Journal Article Mod Pathol · October 2007 Placental site trophoblastic tumor is a neoplasm of extravillous intermediate trophoblast at the implantation site, preceded in the majority of cases by a female gestational event. Our pilot investigation suggested that the development of this tumor might ... Full text Link to item Cite

Function and molecular mechanisms of neuroendocrine cells in prostate cancer.

Journal Article Anal Quant Cytol Histol · June 2007 Benign prostate contains luminal epithelial cells, basal cells and a minor component of neuroendocrine cells whose function may be to regulate the growth, differentiation and secretory function of the prostate gland. Neuroendocrine (NE) cells are also pres ... Link to item Cite

The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors.

Journal Article J Urol · May 2007 PURPOSE: The role of androgen receptor coactivators in testicular development and cancer formation is unclear. p44/Mep50 was identified as an androgen receptor coactivator that functions in a complex with protein arginine methyltransferase 5. We studied th ... Full text Link to item Cite

Littoral cell angioma of the spleen.

Journal Article AJR Am J Roentgenol · May 2007 Full text Link to item Cite

Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer.

Journal Article J Biol Chem · February 9, 2007 Hormonal therapy of prostate cancer, by inhibiting androgen production and/or androgen function, is the treatment of choice for advanced prostate cancer. Although most patients respond initially, the effect is only temporary, and the tumor cells will resum ... Full text Link to item Cite

Is there a role for platinum chemotherapy in the treatment of patients with hormone-refractory prostate cancer?

Journal Article Cancer · February 1, 2007 Docetaxel chemotherapy is the current standard of care for metastatic hormone-refractory prostate cancer (HRPC). Platinum chemotherapy drugs, such as cisplatin and carboplatin, have moderate single-agent activity in HRPC. Next-generation platinum drugs, in ... Full text Link to item Cite

Malakoplakia of the prostate on needle core biopsy: a case report and review of the literature.

Journal Article Int J Surg Pathol · January 2007 Malakoplakia is a rare inflammatory disorder that results from an infectious process and that may be associated with immunosuppression. It most often occurs in the genitourinary tract; however, isolated cases have been reported in many other organs, includ ... Full text Link to item Cite

Soft tissue tumors in the prostate

Journal Article Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology · 2007 Cite

Littoral cell angioma of spleen: Radiologic-pathologic correlation

Journal Article AJR. American journal of roentgenology · 2007 Cite

Mechanical properties of human prostate tissue in the context of surgical needle insertion

Journal Article International Journal for Computer Assisted Radiology and Surgery · 2007 Cite

Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression.

Journal Article Mod Pathol · October 2006 Prostate carcinoma is a hormonally driven age-related neoplasm. Cellular senescence is an age-related process where cells remain metabolically active but in a growth-arrested state at the G1 phase. p14(ARF), p15(INK4b), and p16(INK4a), which are known to r ... Full text Link to item Cite

Immunohistochemical characterization of neuroendocrine cells in prostate cancer.

Journal Article Prostate · September 15, 2006 BACKGROUND: Neuroendocrine (NE) cells increase in high grade/stage prostate cancer (PC) and may contribute to androgen-independent cancer. Their immunohistochemical phenotype has not been studied in detail and conflicting results have been reported. METHOD ... Full text Link to item Cite

[Neuroendocrine differentiation in prostate cancer].

Journal Article Zhonghua Bing Li Xue Za Zhi · September 2006 Link to item Cite

Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer.

Journal Article Prostate · August 1, 2006 BACKGROUND: Prostate cancer (PC) contains a minor component of neuroendocrine (NE) cells that may stimulate androgen-independent growth of the tumor. The mechanism of neuroendocrine differentiation remains unknown. METHODS: The expression of PTP1B, a prote ... Full text Link to item Cite

Small cell carcinoma of the prostate: an immunohistochemical study.

Journal Article Am J Surg Pathol · June 2006 Small cell carcinoma of the prostate (SCPC) is morphologically similar to small cell carcinoma of the lung (SCLC) and maybe misinterpreted as Gleason pattern 5b prostate adenocarcinoma (HGPC). Recognition of SCPC is important because of its different clini ... Full text Link to item Cite

Early detection and measurement of urothelial tumors in mice.

Journal Article Urology · June 2006 OBJECTIVES: To establish reliable noninvasive in vivo methods to detect, measure, and monitor experimentally induced urothelial tumors in mice. METHODS: UPII-SV40T transgenic mice reliably develop bladder tumors by expression of simian virus 40 large T ant ... Full text Link to item Cite

Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma vs cholangiocarcinoma and metastatic carcinoma of the liver.

Journal Article Am J Clin Pathol · April 2006 The cytoplasmic staining of thyroid transcription factor (TTF)-1 was analyzed in 86 liver resection specimens, including 40 hepatocellular carcinoma (HCC), 4 metastatic HCC, 20 cholangiocarcinoma, 2 combined hepatocellular-cholangiocarcinoma (CHC), and 20 ... Full text Link to item Cite

IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1.

Journal Article Oncogene · February 16, 2006 Synovial sarcoma is an aggressive soft tissue tumor characterized by a specific chromosomal translocation between chromosome 18 and X. This translocation can generate a fusion transcript encoding SYT-SSX1, a transforming oncoprotein. We present evidence th ... Full text Link to item Cite

Overexpression of decoy receptor 3 in precancerous lesions and adenocarcinoma of the esophagus.

Journal Article Am J Clin Pathol · August 2005 Overexpression of decoy receptor (DcR) 3 protein, a recently discovered member of the tumor necrosis factor receptor superfamily, was examined in 40 esophagogastrectomy specimens containing areas of Barrett esophagus (n = 27), low-grade dysplasia (n = 27), ... Full text Link to item Cite

Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer.

Journal Article Am J Pathol · June 2005 Hormonal therapy (androgen ablation and/or inhibition of androgen action) is the treatment of choice for advanced prostate cancer. After an initial response in most patients, tumors invariably progress to an androgen-independent state. It is unclear how pr ... Full text Link to item Cite

Cell culture block array for immunocytochemical study of protein expression in cultured cells.

Journal Article Appl Immunohistochem Mol Morphol · March 2005 Immunocytochemical staining of cultured cells using specific antibodies is a powerful technique to study the expression and subcellular localization of proteins. However, this technique is associated with sample-to-sample variations because samples are han ... Full text Link to item Cite

Overexpression of decoy receptor 3 in precancerous lesions and adenocarcinoma of the esophagus

Journal Article American Journal of Clinical Pathology · January 1, 2005 Overexpression of decoy receptor (DcR) 3 protein, a recently discovered member of the tumor necrosis factor receptor superfamily, was examined in 40 esophagogastrectomy specimens containing areas of Barrett esophagus (n = 27), low-grade dysplasia (n = 27), ... Full text Cite

Neuroendocrine differentiation in prostate cancer

Journal Article Proceedings of the 4th Asian-Pacific International Academy of Pathology Congress · 2005 Cite

Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma.

Journal Article Arch Pathol Lab Med · December 2004 CONTEXT: Human carcinoma-associated antigen (HCA) is a mucin glycoprotein recognized by antibodies raised against epiglycanin, the latter having been originally purified from mouse mammary carcinoma cells. Human carcinoma-associated antigen expression is i ... Full text Link to item Cite

Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions.

Journal Article Am J Clin Pathol · November 2004 The expression of human carcinoma-associated antigen (HCA), a mucin-type glycoprotein, was assessed in 50 esophagogastrectomy specimens. Areas, each from different cases, of Barrett esophagus (n = 36), low-grade dysplasia (n = 38), high-grade dysplasia/car ... Full text Link to item Cite

Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer.

Journal Article J Biol Chem · August 6, 2004 Androgen receptor (AR)-associated coregulator 70 (ARA70) was the first identified AR coregulator. However, its molecular mechanism and biological relevance to prostate cancer remain unclear. Here we show that ARA70 interacts with and promotes AR activity v ... Full text Link to item Cite

Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma.

Journal Article Am J Surg Pathol · August 2004 Recently, it was reported that RON proto-oncogene, encoding a receptor tyrosine kinase, was strongly expressed in renal oncocytomas but not in any renal cell carcinomas, including 5 chromophobe renal cell carcinomas, which morphologically resemble oncocyto ... Full text Link to item Cite

Overexpression of human carcinoma-associated antigen in urothelial carcinoma of the bladder.

Journal Article Arch Pathol Lab Med · July 2004 CONTEXT: Human carcinoma-associated antigen (HCA) is a mucin protein whose level is increased in the sera of patients with a variety of carcinomas. We have previously shown that prostatic carcinoma overexpresses HCA in comparison to benign prostatic tissue ... Full text Link to item Cite

Renal oncocytosis presenting in childhood: a case report.

Journal Article Int J Surg Pathol · October 2003 Renal oncocytosis is a rare condition in which a spectrum of oncocytic lesions, including oncocytomas, diffusely involve the kidney. Few cases have been reported and all were in adult patients. We report here such a case in a 12-year-old girl. In addition ... Full text Link to item Cite

Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery.

Journal Article Biochem Biophys Res Commun · January 10, 2003 Several epidemiological studies have demonstrated that vitamin E is a chemopreventative agent for prostate cancer. alpha-Tocopheryl succinate (VES), a derivative of vitamin E, effectively modulates prostate cancer cell growth. However, little is known abou ... Full text Link to item Cite

Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.

Journal Article Cancer Res · November 1, 2002 Whereas hydroxyflutamide (HF) has been used as an antiandrogen to block androgen-stimulated prostate tumor growth, the antiandrogen withdrawal syndrome that allows antiandrogens to stimulate prostate tumor growth still occurs in many patients treated with ... Link to item Cite

Clonality of combined tumors.

Journal Article Arch Pathol Lab Med · April 2002 CONTEXT: Tumors with mixed morphologic patterns (combined tumors) are sometimes encountered, and questions often arise regarding the mechanism of molecular pathogenesis of each component and their relationships. OBJECTIVE: To determine whether different co ... Full text Link to item Cite

Clonality of combined tumors: A molecular genetic study

Journal Article Archives of Pathology & Laboratory Medicine · 2002 Cite

Application of flow cytometry in the diagnosis and differential disgnosis of lymphoma and leukemia

Journal Article Zhonghua bing li xue za zhi Chinese journal of pathology · 2002 Cite

Molecular analysis of synchronous and metachronous tumors of the lung: impact on management and prognosis.

Journal Article Ann Diagn Pathol · December 2001 Patients with pulmonary neoplasms have an increased risk for developing a second tumor of the lung, either at the same time or different times. It is important to determine if the second tumor represents an independent primary tumor (ie, a synchronous or a ... Full text Link to item Cite

Association between initial diagnostic procedure and hysteroscopy and abnormal peritoneal washings in patients with endometrial carcinoma.

Journal Article Cancer · June 25, 2000 BACKGROUND: Hysteroscopy has been implicated in the finding of positive peritoneal washings (PW) in patients with endometrial carcinoma in several case reports. The current study was designed to evaluate whether there was an increased incidence rate of pos ... Full text Link to item Cite

Massive Atrial Septal Lipomatous Hypertrophy.

Journal Article Echocardiography · November 1999 Full text Link to item Cite

Activation of human thymocytes induces the phosphorylation of protein tyrosine phosphatase IC

Journal Article Comptes rendus de l'Académie des Sciences Paris de la vie/Life Sciences · 1995 Cite

Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.

Journal Article J Biol Chem · June 24, 1994 Binding of fibroblast growth factor (FGF) to the fibroblast growth factor receptor leads to autophosphorylation of the receptor on several tyrosine residues. Wild-type FGF receptor 1 (flg) and a mutated receptor (Y766F), in which an autophosphorylation sit ... Link to item Cite

The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system.

Journal Article J Biol Chem · May 15, 1993 We have isolated cDNA clones and deduced the complete amino acid sequence of a large receptor-type protein tyrosine phosphatase containing 2307 amino acids. The human gene encoding this phosphatase, denoted RPTP beta (or PTP zeta), has been localized to ch ... Link to item Cite

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.

Journal Article Science · March 12, 1993 Regulation of cell proliferation, differentiation, and metabolic homeostasis is associated with the phosphorylation and dephosphorylation of specific tyrosine residues of key regulatory proteins. The phosphotyrosine phosphatase 1D (PTP 1D) contains two ami ... Full text Link to item Cite

Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein.

Journal Article Cell · April 19, 1991 Adenovirus (Ad) infection results in a marked inhibition of cellular protein synthesis that initiates during the late phase of the viral infectious cycle. We show that the mechanism used for suppression of cellular protein synthesis during cell cycle progr ... Full text Link to item Cite

Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex.

Journal Article J Virol · June 1990 The adenovirus tripartite leader is a 200-nucleotide-long 5' noncoding region which facilitates translation of viral mRNAs at late times after infection. The tripartite leader also confers the ability to initiate translation independent of the requirement ... Full text Link to item Cite

Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine

Journal Article Proceedings of the National Academy of Sciences of the United States of America · 1990 Cite