Scholars@Duke
Jillian Hurst

Jillian Hurst

Associate Professor in Pediatrics
Pediatrics, Children's Health Discovery Institute
jillian.hurst@duke.edu
3 Genome Court, MSRB3, 4022 Bay 22, Durham, NC 27710

Selected Publications

Age and antibiotic use influence longitudinal dynamics of the upper respiratory microbiome in children with recurrent acute otitis media.

Journal Article mSphere · December 23, 2025 UNLABELLED: The upper respiratory tract (URT) microbiome has emerged as a key component of acute otitis media (AOM) pathophysiology; however, few studies conducted to date have evaluated URT microbiome composition in children with recurrent AOM (rAOM). We ... Full text Link to item Cite

Unsupervised Coverage Sampling to Enhance Clinical Chart Review Coverage for Computable Phenotype Development: Simulation and Empirical Study.

Journal Article JMIR Med Inform · November 27, 2025 BACKGROUND: Developing computable phenotypes (CP) based on electronic health records (EHR) data requires "gold-standard" labels for the outcome of interest. To generate these labels, clinicians typically chart-review a subset of patient charts. Charts to b ... Full text Link to item Cite

Pediatric T cell and B cell responses to SARS-CoV-2 infection.

Journal Article JCI Insight · October 22, 2025 BACKGROUNDUnderstanding age-associated differences in acute and memory adaptive immunity to SARS-CoV-2 and how they contribute to more favorable outcomes in children is critically important.METHODSWe evaluated SARS-CoV-2-specific T cell, B cell, and antibo ... Full text Link to item Cite

Decreased Microbiota-Driven Tyrosine Metabolism Is Associated With Symptomatic COVID-19 in Children.

Journal Article J Infect Dis · October 15, 2025 BACKGROUND: The gut microbiota has been implicated in driving coronavirus disease 2019 (COVID-19) disease severity, but the underlying mechanisms remain unknown. We investigated the relationship between the gut microbiota and development of symptomatic COV ... Full text Link to item Cite

Silicone Ankle Bands as a Tool to Assess Infant Exposures to Semivolatile Organic Chemicals in Indoor Environments.

Journal Article Environ Sci Technol Lett · October 14, 2025 Exposure to organophosphate esters (OPEs), used as flame retardants and plasticizers, is highly variable in the general population, and limited data exist on exposures in young children. This study evaluated the use of silicone ankle bands to assess OPE ex ... Full text Link to item Cite

An analytic approach considering two temporal mechanisms driving breakthrough viral infections after vaccination.

Journal Article Vaccine · September 17, 2025 Real world data is an increasingly utilized resource for post-market monitoring of vaccines and provides insight into real world effectiveness. However, heterogeneous mechanisms may drive observed breakthrough infections among vaccinated individuals, such ... Full text Link to item Cite

Differential Use of Depression and Anxiety Medications in Adults With a History of Cancer.

Journal Article JAMA Netw Open · August 1, 2025 IMPORTANCE: Depression and anxiety disproportionately impact cancer survivors. Sociodemographic factors frequently impact access to cancer care; however, it is unclear if these factors are associated with access to pharmacological care for mental and behav ... Full text Link to item Cite

Cell-specific expression biases in human cortex of genes associated with neurodevelopmental disorders.

Journal Article Sci Rep · July 2, 2025 Up to one third of congenital brain malformations and neurodevelopmental disorders are attributable to single-gene pathogenic variants, and yet we have little understanding of the cellular pathophysiology in the nervous system that arises from these varian ... Full text Link to item Cite

Corynebacterium rhinophilum sp. nov. isolated from the human upper respiratory tract.

Journal Article Int J Syst Evol Microbiol · July 2025 Twelve strains of a novel Corynebacterium species were cultured from human respiratory samples collected in the USA and Botswana. Five strains underwent detailed phenotypic and chemotaxonomic characterization, while all 12 strains were included in phylogen ... Full text Link to item Cite

Genome mining identifies a diversity of natural product biosynthetic capacity in human respiratory Corynebacterium strains.

Journal Article mSphere · June 25, 2025 Corynebacterium species, integral to the healthy human upper respiratory tract (URT) microbiota, remain underexplored in microbial genomics for their potential to promote respiratory health and exclude pathobionts. This genomic study investigated the diver ... Full text Link to item Cite

Role of the upper airway microbiota in respiratory virus and bacterial pathobiont dynamics in the first year of life.

Journal Article Nat Commun · June 4, 2025 The mechanisms by which respiratory viruses predispose to secondary bacterial infections remain poorly characterized. Using 2,409 nasopharyngeal swabs from 300 infants enrolled in a prospective cohort study in Botswana, we perform a detailed analysis of fa ... Full text Link to item Cite

Dietary plant diversity predicts early life microbiome maturation.

Journal Article medRxiv · May 14, 2025 Despite established links between the infant gut microbiome and health, how complementary feeding shapes colonization remains unclear. Using FoodSeq, a DNA-based dietary assessment technique, we surveyed food intake across 729 children (0-3 y) from North a ... Full text Link to item Cite

Commensal bacteria inhibit viral infections via a tryptophan metabolite.

Journal Article bioRxiv · May 12, 2025 Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplored. Here we define a pat ... Full text Link to item Cite

Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection.

Journal Article Nat Commun · March 10, 2025 Age is among the strongest risk factors for severe outcomes from SARS-CoV-2 infection. Here we describe upper respiratory tract (URT) and peripheral blood transcriptomes of 202 participants (age range of 1 week to 83 years), including 137 non-hospitalized ... Full text Open Access Link to item Cite

Linking Electronic Health Record Prescribing Data and Pharmacy Dispensing Records to Identify Patient-Level Factors Associated With Psychotropic Medication Receipt: Retrospective Study.

Journal Article JMIR Med Inform · March 4, 2025 BACKGROUND: Pharmacoepidemiology studies using electronic health record (EHR) data typically rely on medication prescriptions to determine which patients have received a medication. However, such data do not affirmatively indicate whether these prescriptio ... Full text Link to item Cite

In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions.

Journal Article J Clin Invest · November 12, 2024 Human cytomegalovirus (HCMV) profoundly impacts host T and NK cells across the lifespan, yet how this common congenital infection modulates developing fetal immune cell compartments remains underexplored. Using cord blood from neonates with and without con ... Full text Link to item Cite

Child Sexual Abuse Documentation in Primary Care Settings.

Journal Article Clin Pediatr (Phila) · October 2024 Primary care providers (PCPs) can play an important role in the continuity of care for children who experience sexual abuse (SA). We performed a retrospective, chart-based study of children 3 to 17 years old with SA history. Primary care medical records we ... Full text Link to item Cite

Metformin use associated with lower rate of hospitalization for influenza in individuals with diabetes.

Journal Article Diabetes Obes Metab · August 2024 AIM: To investigate if patients with diabetes taking metformin have better outcomes versus those not taking metformin following an emergency room visit for influenza. METHODS: Using electronic medical records, we performed a retrospective chart review of a ... Full text Link to item Cite

Dolosigranulum savutiense sp. nov., isolated from human upper respiratory samples collected in Botswana.

Journal Article Int J Syst Evol Microbiol · August 2024 Four strains (MSK211, MSK294T, MSK312, MSK433) of a novel Dolosigranulum species were cultured from nasopharyngeal swabs collected from mother-infant dyads in southern Botswana. These strains grew optimally on tryptic soy agar with 5% sheep blood solid med ... Full text Link to item Cite

Understanding the influence of the microbiome on childhood infections.

Journal Article Expert Rev Anti Infect Ther · July 2024 INTRODUCTION: The microbiome is known to have a substantial impact on human health and disease. However, the impacts of the microbiome on immune system development, susceptibility to infectious diseases, and vaccine-elicited immune responses are emerging a ... Full text Link to item Cite

Immunogenicity of Monovalent mRNA-1273 and BNT162b2 Vaccines in Children <5 Years of Age.

Journal Article Pediatrics · June 1, 2024 BACKGROUND AND OBJECTIVES: The messenger RNA (mRNA)-based coronavirus disease 2019 vaccines approved for use in children <5 years of age have different antigen doses and administration schedules that could affect vaccine immunogenicity and effectiveness. W ... Full text Open Access Link to item Cite

A guide to successful management of collaborative partnerships in quantitative research: An illustration of the science of team science.

Journal Article Stat (Int Stat Inst) · June 2024 Data-intensive research continues to expand with the goal of improving healthcare delivery, clinical decision-making, and patient outcomes. Quantitative scientists, such as biostatisticians, epidemiologists, and informaticists, are tasked with turning data ... Full text Link to item Cite

Identifying associations between genetic conditions in offspring and pregnancy health complications

Journal Article Reproductive, Female and Child Health · June 2024 AbstractBackgroundPrior research has identified associations between pregnancy complications and specific genetic diagnoses in ... Full text Cite

Population Pharmacokinetics of Caffeine in Neonates with Congenital Heart Disease and Associations with Acute Kidney Injury.

Journal Article J Clin Pharmacol · March 2024 Cardiac surgery-associated acute kidney injury (CS-AKI) occurs in approximately 65% of neonates undergoing cardiac surgery on cardiopulmonary bypass and contributes to morbidity and mortality. Caffeine may reduce CS-AKI by counteracting adenosine receptor ... Full text Open Access Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal Article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Open Access Link to item Cite

What Do Child Abuse and Neglect Medical Evaluation Consultation Notes Tell Researchers and Clinicians?

Journal Article Child Maltreat · February 2024 Child abuse and neglect (CAN) medical experts provide specialized multidisciplinary care to children when there is concern for maltreatment. Their clinical notes contain valuable information on child- and family-level factors, clinical concerns, and servic ... Full text Link to item Cite

Serotype epidemiology and antibiotic resistance of pneumococcal isolates colonizing infants in Botswana (2016-2019).

Journal Article PLoS One · 2024 BACKGROUND: In 2012, Botswana introduced 13-valent pneumococcal conjugate vaccine (PCV-13) to its childhood immunization program in a 3+0 schedule, achieving coverage rates of above 90% by 2014. In other settings, PCV introduction has been followed by an i ... Full text Link to item Cite

What do child maltreatment reports to Child Protective Services tell us about the needs families and communities are experiencing?

Journal Article Child Youth Serv Rev · December 2023 Intake reports from child protective service (CPS) agencies are the foundation for subsequent decisions and services within the child welfare system. They provide valuable information for understanding children's needs, yet the unstructured way that inform ... Full text Link to item Cite

Host microbiome-pathogen interactions in pediatric infections.

Journal Article Curr Opin Infect Dis · October 1, 2023 PURPOSE OF REVIEW: In this review, we discuss recent research that has furthered our understanding of microbiome development during childhood, the role of the microbiome in infections during this life stage, and emerging opportunities for microbiome-based ... Full text Link to item Cite

Leveraging the human microbiota to target bacterial respiratory pathogens: new paths toward an expanded antimicrobial armamentarium.

Journal Article mBio · August 31, 2023 Acute respiratory infections are the most frequent infections across the lifespan and are the leading infectious cause of death among children globally. Bacterial respiratory infections are routinely treated with antibiotics, nearly all of which are derive ... Full text Link to item Cite

Comparing Natural Language Processing and Structured Medical Data to Develop a Computable Phenotype for Patients Hospitalized Due to COVID-19: Retrospective Analysis.

Journal Article JMIR Med Inform · August 22, 2023 BACKGROUND: Throughout the COVID-19 pandemic, many hospitals conducted routine testing of hospitalized patients for SARS-CoV-2 infection upon admission. Some of these patients are admitted for reasons unrelated to COVID-19 and incidentally test positive fo ... Full text Link to item Cite

ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission.

Journal Article JCI Insight · July 10, 2023 Human cytomegalovirus (HCMV) is the most common vertically transmitted infection worldwide, yet there are no vaccines or therapeutics to prevent congenital HCMV (cCMV) infection. Emerging evidence indicates that antibody Fc effector functions may be a prev ... Full text Link to item Cite

Comparing Natural Language Processing and Structured Medical Data to Develop a Computable Phenotype for Patients Hospitalized Due to COVID-19: Retrospective Analysis.

Journal Article JMIR Med Inform · June 17, 2023 BACKGROUND: Throughout the COVID-19 pandemic, many hospitals conducted routine testing of hospitalized patients for SARS-CoV-2 infection upon admission. Some of these patients are admitted for reasons unrelated to COVID-19, and incidentally test positive f ... Full text Link to item Cite

Use of Structured Electronic Health Records Data Elements for the Development of Computable Phenotypes to Identify Potential Adverse Events Associated with Intravenous Immunoglobulin Infusion.

Journal Article Drug Saf · March 2023 INTRODUCTION: Detection of adverse reactions to drugs and biologic agents is an important component of regulatory approval and post-market safety evaluation. Real-world data, including insurance claims and electronic health records data, are increasingly u ... Full text Link to item Cite

Assisted reproductive technology and association with childhood cancer subtypes.

Journal Article Cancer Med · February 2023 OBJECTIVES: To investigate the association between assisted reproductive technology (ART) use and childhood cancer subtype. STUDY DESIGN: We deployed a cross-sectional survey of 1701 parents of children with cancer about their ART use, demographics, and ge ... Full text Link to item Cite

Do children evaluated for maltreatment have higher subsequent emergency department and inpatient care utilization compared to a general pediatric sample?

Journal Article Child Abuse Negl · December 2022 BACKGROUND: Child maltreatment leads to substantial adverse health outcomes, but little is known about acute health care utilization patterns after children are evaluated for a concern of maltreatment at a child abuse and neglect medical evaluation clinic. ... Full text Link to item Cite

An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition.

Journal Article Neurobiol Aging · October 2022 Genome-wide association studies (GWAS) have identified common single nucleotide polymorphisms (SNPs) that increase late-onset Alzheimer's disease (LOAD) risk. To identify additional LOAD-associated variants and provide insight into underlying disease biolo ... Full text Link to item Cite

Age-Related Changes in the Nasopharyngeal Microbiome Are Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Symptoms Among Children, Adolescents, and Young Adults.

Journal Article Clin Infect Dis · August 24, 2022 BACKGROUND: Children are less susceptible to SARS-CoV-2 infection and typically have milder illness courses than adults, but the factors underlying these age-associated differences are not well understood. The upper respiratory microbiome undergoes substan ... Full text Open Access Link to item Cite

Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection.

Journal Article J Clin Invest · August 15, 2022 Human cytomegalovirus (HCMV) is the most common congenital infection and a leading cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide. Development of a maternal vaccine or therapeutic to prevent congenital HCMV has bee ... Full text Open Access Link to item Cite

Kinetics of pneumococcal antibodies among HIV-exposed, uninfected infants in Botswana.

Journal Article Vaccine · August 5, 2022 BACKGROUND: Streptococcus pneumoniae is a leading cause of severe infections among children. Despite vaccination, HIV-exposed, uninfected (HEU) children have a higher incidence of invasive pneumococcal disease than HIV-unexposed, uninfected (HUU) children. ... Full text Link to item Cite

Asthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents.

Journal Article Pediatrics · June 1, 2022 OBJECTIVES: Over 6 million pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have occurred in the United States, but risk factors for infection remain poorly defined. We sought to evaluate the association between asthma and ... Full text Link to item Cite

Environmental and clinical data utility in pediatric asthma exacerbation risk prediction models.

Journal Article BMC Med Inform Decis Mak · April 22, 2022 BACKGROUND: Asthma exacerbations are triggered by a variety of clinical and environmental factors, but their relative impacts on exacerbation risk are unclear. There is a critical need to develop methods to identify children at high-risk for future exacerb ... Full text Link to item Cite

Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia.

Journal Article Clin Infect Dis · April 9, 2022 BACKGROUND: Placentally transferred maternal immunoglobulin G (IgG) protects against pathogens in early life, yet vertically transmitted infections can interfere with transplacental IgG transfer. Although human cytomegalovirus (HCMV) is the most common pla ... Full text Open Access Link to item Cite

Combining adult with pediatric patient data to develop a clinical decision support tool intended for children: leveraging machine learning to model heterogeneity.

Journal Article BMC Med Inform Decis Mak · March 29, 2022 BACKGROUND: Clinical decision support (CDS) tools built using adult data do not typically perform well for children. We explored how best to leverage adult data to improve the performance of such tools. This study assesses whether it is better to build CDS ... Full text Open Access Link to item Cite

Non-diphtheriae Corynebacterium species are associated with decreased risk of pneumococcal colonization during infancy.

Journal Article ISME J · March 2022 Streptococcus pneumoniae (pneumococcus) is a leading cause of severe infections among children and adults. Interactions between commensal microbes in the upper respiratory tract and S. pneumoniae are poorly described. In this study, we sought to identify i ... Full text Link to item Cite

Using Electronic Health Records to understand the population of local children captured in a large health system in Durham County, NC, USA, and implications for population health research.

Journal Article Soc Sci Med · March 2022 Although local policies aimed at reducing childhood health inequities can benefit from local data, sample size constraints in population representative health surveys often prevent rigorous evaluations of child health disparities and health care patterns a ... Full text Link to item Cite

Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.

Journal Article Clin Infect Dis · November 2, 2021 BACKGROUND: Child with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection typically have mild symptoms that do not require medical attention, leaving a gap in our understanding of the spectrum of SARS-CoV-2-related illnesses that the vi ... Full text Open Access Link to item Cite

Reduced pediatric urgent asthma utilization and exacerbations during the COVID-19 pandemic.

Journal Article Pediatr Pulmonol · October 2021 The COVID-19 pandemic has had a profound impact on healthcare access and utilization, which could have important implications for children with chronic diseases, including asthma. We sought to evaluate changes in healthcare utilization and outcomes in chil ... Full text Link to item Cite

Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.

Journal Article JCI Insight · September 8, 2021 As SARS-CoV-2 continues to spread globally, questions have emerged regarding the strength and durability of immune responses in specific populations. In this study, we evaluated humoral immune responses in 69 children and adolescents with asymptomatic or m ... Full text Link to item Cite

Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.

Journal Article medRxiv · April 20, 2021 As SARS-CoV-2 continues to spread globally, questions have emerged regarding the strength and durability of immune responses in specific populations. In this study, we evaluated humoral immune responses in 69 children and adolescents with asymptomatic or m ... Full text Link to item Cite

Age-related changes in the upper respiratory microbiome are associated with SARS-CoV-2 susceptibility and illness severity.

Journal Article medRxiv · March 23, 2021 UNLABELLED: Children are less susceptible to SARS-CoV-2 and typically have milder illness courses than adults. We studied the nasopharyngeal microbiomes of 274 children, adolescents, and young adults with SARS-CoV-2 exposure using 16S rRNA gene sequencing. ... Full text Open Access Link to item Cite

Assisted reproductive technology and association with childhood cancer subtypes

Journal Article · 2021 ABSTRACTObjectives Use of assisted reproductive technology (ART) may alter the typical course of fetal development. We sought to investigate the association between ART use and childhood cancer subtype. Study design We surveyed ... Full text Cite

Reduced Pediatric Urgent Asthma Utilization and Exacerbations During the COVID-19 Pandemic

Journal Article · 2021 ABSTRACTBackground and Objectives The COVID-19 pandemic has had a profound impact on healthcare access and utilization, which could have important implications for children with chronic diseases, including asthma. We sought to evaluate c ... Full text Cite

Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection

Journal Article · 2021 Human cytomegalovirus (HCMV) is the most common congenital infection and a leading cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide. Development of a maternal vaccine or therapeutic to prevent congenital infection ha ... Full text Open Access Cite

Well-Child Care Attendance and Risk of Asthma Exacerbations.

Journal Article Pediatrics · December 2020 BACKGROUND: Asthma remains a leading cause of hospitalization in US children. Well-child care (WCC) visits are routinely recommended, but how WCC adherence relates to asthma outcomes is poorly described. METHODS: We conducted a retrospective longitudinal c ... Full text Link to item Cite

Lessons From COVID-19 in Children: Key Hypotheses to Guide Preventative and Therapeutic Strategies.

Journal Article Clin Infect Dis · November 5, 2020 The current pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), reveals a peculiar trend of milder disease and lower case fatality in children compared with adults. Consisten ... Full text Link to item Cite

Provision and Utilization of Team- and Community-Based Operative Care for Patients With Cleft Lip/Palate in North Carolina.

Journal Article Cleft Palate Craniofac J · November 2020 OBJECTIVE: To characterize operative care for cleft lip and/or palate (CL/P) based on location (ie, from American Cleft Palate Craniofacial Association [ACPA]-approved multidisciplinary teams or from community providers). DESIGN: Cross-sectional analysis o ... Full text Open Access Link to item Cite

Genetic variation associated with childhood and adult stature and risk of MYCN-amplified neuroblastoma.

Journal Article Cancer Med · November 2020 BACKGROUND: Neuroblastoma is the most common pediatric solid tumor. MYCN-amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood. Genetic determinants of stature increase risk of s ... Full text Open Access Link to item Cite

Evaluation of associations between asthma exacerbations and distance to roadways using geocoded electronic health records data.

Journal Article BMC Public Health · October 29, 2020 BACKGROUND: Asthma exacerbations in children often require medications, urgent care, and hospitalization. Multiple environmental triggers have been associated with asthma exacerbations, including particulate matter 2.5 (PM2.5) and ozone, which are primaril ... Full text Link to item Cite

Cytomegalovirus as an immunomodulator across the lifespan.

Journal Article Curr Opin Virol · October 2020 Human cytomegalovirus (HCMV) is a nearly ubiquitous β-herpesvirus that establishes latent infection in the majority of the world's population. HCMV infection profoundly influences the host immune system and, perhaps more than any other human pathogen, has ... Full text Link to item Cite

SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.

Journal Article medRxiv · September 1, 2020 BACKGROUND: Children with SARS-CoV-2 infection typically have mild symptoms that do not require medical attention, leaving a gap in our understanding of the spectrum of illnesses that the virus causes in children. METHODS: We conducted a prospective cohort ... Full text Open Access Link to item Cite

Leveraging Genome and Phenome-Wide Association Studies to Investigate Genetic Risk of Acute Lymphoblastic Leukemia.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2020 BACKGROUND: Genome-wide association studies (GWAS) of childhood cancers remain limited, highlighting the need for novel analytic strategies. We describe a hybrid GWAS and phenome-wide association study (PheWAS) approach to uncover genotype-phenotype relati ... Full text Link to item Cite

Development of an electronic health records datamart to support clinical and population health research.

Journal Article J Clin Transl Sci · June 23, 2020 INTRODUCTION: Electronic health record (EHR) data have emerged as an important resource for population health and clinical research. There have been significant efforts to leverage EHR data for research; however, given data security concerns and the comple ... Full text Link to item Cite

Performance of an electronic health record definition for pediatric asthma

Conference JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY · February 1, 2020 Link to item Cite

Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population.

Journal Article Bone · January 2020 Osteosarcoma, a malignant primary bone tumor most commonly diagnosed in children and adolescents, has a poorly understood genetic etiology. Genome-wide association studies (GWAS) and candidate-gene analyses have identified putative risk variants in subject ... Full text Link to item Cite

Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway.

Journal Article J Biol Chem · October 4, 2019 The mating pathway in yeast Saccharomyces cerevisiae has long been used to reveal new mechanisms of signal transduction. The pathway comprises a pheromone receptor, a heterotrimeric G protein, and intracellular effectors of morphogenesis and transcription. ... Full text Open Access Link to item Cite

Cultivating Research Skills During Clinical Training to Promote Pediatric-Scientist Development.

Journal Article Pediatrics · August 2019 Physician-scientists represent a critical component of the biomedical and health research workforce. However, the proportion of physicians who spend a significant amount of effort on scientific research has declined over the past 40 years. This trend has b ... Full text Open Access Link to item Cite

Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.

Journal Article J Biol Chem · June 28, 2013 Ubiquitination is a post-translational modification that tags proteins for proteasomal degradation. In addition, there is a growing appreciation that ubiquitination can influence protein activity and localization. Ste7 is a prototype MAPKK in yeast that pa ... Full text Link to item Cite

Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells.

Journal Article Mol Cancer · November 2, 2010 BACKGROUND: A critical therapeutic challenge in epithelial ovarian carcinoma is the development of chemoresistance among tumor cells following exposure to first line chemotherapeutics. The molecular and genetic changes that drive the development of chemore ... Full text Link to item Cite

Regulator of G-protein signaling (RGS) proteins in cancer biology.

Journal Article Biochem Pharmacol · November 15, 2009 The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). In recent years, GPCRs have been linked to the initiation and progre ... Full text Link to item Cite

Regulator of G-protein signalling expression and function in ovarian cancer cell lines.

Journal Article Cell Mol Biol Lett · 2009 Regulator of G-protein signalling (RGS)(2) proteins critically regulate signalling cascades initiated by G-protein coupled receptors (GPCRs) by accelerating the deactivation of heterotrimeric G-proteins. Lysophosphatidic acid (LPA) is the predominant growt ... Full text Link to item Cite

Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways.

Journal Article Pharmacology · 2009 BACKGROUND/AIMS: Lysophosphatidic acid (LPA) is an autocrine growth signal critical to the initiation and progression of ovarian cancer. In the current study, we investigated the receptors and signaling cascades responsible for mediating LPA-stimulated cel ... Full text Link to item Cite

Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology.

Journal Article BMC Neurosci · December 11, 2008 BACKGROUND: Lysophospholipids regulate the morphology and growth of neurons, neural cell lines, and neural progenitors. A stable human neural progenitor cell line is not currently available in which to study the role of lysophospholipids in human neural de ... Full text Link to item Cite

Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells.

Journal Article Cell Signal · February 2008 Lysophosphatidic acid is a bioactive phospholipid that is produced by and stimulates ovarian cancer cells, promoting proliferation, migration, invasion, and survival. Effects of LPA are mediated by cell surface G-protein coupled receptors (GPCRs) that acti ... Full text Link to item Cite