Scholars@Duke
Joanne A. Peebles Wilson

Joanne A. Peebles Wilson

Professor Emeritus of Medicine
Medicine, Gastroenterology
joanne.wilson@duke.edu
Duke Box 3662, Durham, NC 27710
Box 3662, 200 Trent Drive,, 0347 Hosp South, Orange Zone,, Durham, NC 27710

Selected Publications

Medicine's missing dimension.

Journal Article Trans Am Clin Climatol Assoc · 2010 In medicine we tend to restrict practice to using a purely intellectual understanding grounded in science to conceptualize patients and their illnesses. This approach is radically different from the experientially rich healing practices found throughout th ... Link to item Cite

Colon cancer screening in the elderly: when do we stop?

Journal Article Trans Am Clin Climatol Assoc · 2010 Colon cancer is a major cause of cancer death in the US. Screening studies can prevent colon cancer and are recommended for average risk persons beginning at 50 years of age. Compliance with these recommendations has increased, particularly among those ove ... Link to item Cite

Commentary

Journal Article Gastroenterology and Hepatology · January 1, 2009 Cite

Image of the month. Syphilitic proctitis.

Journal Article Clin Gastroenterol Hepatol · April 2008 Full text Link to item Cite

Image of the month. Syphilitic proctitis.

Journal Article Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · April 1, 2008 Cite

Constipation in the elderly.

Journal Article Clin Geriatr Med · August 1999 Featured Publication Constipation is a common concern in the elderly and accounts for significant expenditures on over-the-counter drugs. Although normal aging is not associated with abnormal bowel motility, pathologic and psychosocial conditions lead to increased symptoms in ... Link to item Cite

GI emergencies: rapid therapeutic responses for older patients.

Journal Article Geriatrics · June 1999 Featured Publication Comorbid conditions and decreased physiologic reserves make persons age 65 and older particularly vulnerable to the adverse consequences of acute blood loss. Thus, gastrointestinal bleeding in this population presents an urgent clinical challenge. Treatmen ... Link to item Cite

Clinical images. Melanosis coli.

Journal Article Dig Dis · 1999 Featured Publication Full text Link to item Cite

Whipple's disease

Journal Article Current Opinion in Infectious Diseases · October 20, 1995 Whipple's disease is a multisystem infection caused by a unique, culture-resistant Gram-positive bacterium. Mechanisms of pathogenesis and the interplay of the pathogen with the immune system are poorly understood. It has recently been shown to infect red ... Full text Cite

Gastrointestinal manifestations of amyloidosis.

Journal Article South Med J · February 1994 We reviewed gastrointestinal manifestations in 40 patients with amyloidosis. Gastrointestinal symptoms included anorexia, macroglossia, intestinal pseudo-obstruction, and altered bowel habits. Hepatomegaly was detected in eight patients, but none had clini ... Full text Link to item Cite

Cooccurrence of collagenous colitis with seronegative spondyloarthropathy: report of a case and literature review.

Journal Article J Rheumatol · December 1993 Collagenous colitis is an uncommon cause of chronic watery diarrhea, characterized by colonic deposition of collagen. Nonerosive, oligoarticular, peripheral arthritis has previously been noted in about 7% of patients with collagenous colitis. We describe a ... Link to item Cite

Atypical presentation of inflammatory bowel disease in the elderly.

Journal Article Am J Gastroenterol · December 1993 Despite multiple invasive diagnostic procedures including exploratory laparotomy and surgical resection, our patient's diagnosis remained an enigma. However, given the clinical scenario and the documented PG, a trial of steroids was warranted. The patient ... Link to item Cite

Identification of the Whipple's disease bacillus.

Journal Article N Engl J Med · January 7, 1993 Featured Publication Full text Link to item Cite

Hepatic cytochrome P-4503A (CYP3A) activity in the elderly.

Journal Article Mech Ageing Dev · June 1992 Elderly patients exhibit decreased clearance of multiple drugs biotransformed by the hepatic cytochromes P-450. The cytochromes P-450 are a superfamily of enzymes, which comprise a central component of phase I drug metabolism. Distinct isoforms metabolize ... Full text Link to item Cite

Phylogeny of the Whipple's-disease-associated bacterium.

Journal Article Lancet · August 24, 1991 Featured Publication Efforts to culture and identify the intracellular bacteria associated with Whipple's disease have been unsuccessful. Nucleotide sequencing and amplification by the polymerase chain reaction was done on the bacterial 16 S ribosomal DNA present in a small-bo ... Full text Link to item Cite

HUMAN HEPATIC CYTOCHROME P-450IIIA ACTIVITY IN THE ELDERLY

Journal Article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · August 1, 1991 Link to item Cite

Cholangiocarcinoma. Role of percutaneous transhepatic cholangiography in determination of resectability.

Journal Article Dig Dis Sci · May 1988 Exploratory laparotomy is frequently used to diagnose, treat, or palliate cholangiocarcinoma although surgery is rarely curative. In light of newly developed percutaneous and endoscopic approaches to diagnosis and therapy, we reviewed our experience with 3 ... Full text Link to item Cite

Endoscopic diagnosis of gastritis: causative factors in 100 patients.

Journal Article South Med J · September 1987 The frequency of gastritis in relation to its various predisposing conditions is unclear, as is the respective distribution of damage caused by its predisposing conditions. We studied 100 patients with the endoscopic diagnosis of gastritis. The incidence o ... Full text Link to item Cite

A study of the correlation between endoscopic and histological diagnoses in gastroduodenitis.

Journal Article Am J Gastroenterol · August 1987 Serial histological specimens from 14 patients with the endoscopic diagnosis of erosive gastritis and/or duodenitis were examined for correlation between endoscopic and histological findings. All patients were symptomatic outpatients without history of alc ... Link to item Cite

Intrahepatic cholestasis of pregnancy with marked elevation of transaminases in a black American.

Journal Article Dig Dis Sci · June 1987 A case of intrahepatic cholestasis of pregnancy (ICP) in a black American is presented. This is the first case reported in a black. Marked elevation of transaminases with mild biochemical evidence of cholestasis was initially suggestive of viral hepatitis. ... Full text Link to item Cite

Hepatic failure in adult Niemann-Pick disease.

Journal Article Am J Med Sci · September 1986 The case of a 29-year-old man with Niemann-Pick disease and hepatic failure is presented. Massive hepatomegaly with hepatic calcification were noted in association with a course of persistent hepatitis B serum antigenemia with rapid hepatic decompensation, ... Full text Link to item Cite

Esophagitis caused by nonsteroidal anti-inflammatory medication: case reports and review of the literature on pill-induced esophageal injury.

Journal Article South Med J · September 1986 We report six cases of pill-induced esophageal injury, two of which were caused by the nonsteroidal anti-inflammatory medications ibuprofen and piroxicam, which have not been implicated previously in pill-induced injury. ... Link to item Cite

Gastric xanthomatosis and cholestasis. A causal relationship.

Journal Article Dig Dis Sci · September 1986 We report two cases of gastric xanthomatosis which developed in patients with marked cholestasis. In both cases, one with acute and one with chronic cholestasis, the gastric xanthomas disappeared with resolution of the cholestasis. A review of the literatu ... Full text Link to item Cite

Enteric intussusception presenting as a rapidly enlarging mass.

Journal Article Am J Gastroenterol · June 1986 Enteric intussusception is unusual in adults and frequently presents in a confusing manner. A case of jejunojejunal intussusception is presented in which a 15-cm abdominal mass developed in 24 h. The plain film, barium, and ultrasound findings in enteric i ... Link to item Cite

Richter's syndrome mimicking chronic colitis. A patient with diffuse histiocytic lymphoma complicating chronic lymphocytic leukemia.

Journal Article Dis Colon Rectum · March 1986 A 62-year-old woman developed diffuse histiocytic lymphoma in the course of chronic lymphocytic leukemia and manifested symptoms mimicking chronic ulcerative colitis. Chronic lymphocytic leukemia may be complicated by the development of lymphoma designated ... Full text Link to item Cite

Medication-induced esophagitis.

Journal Article Gastrointest Radiol · 1986 Clinical, radiographic, and endoscopic features of medication-induced esophagitis (MIE) in 4 patients are described. When the clinical history and symptoms raise a high index of suspicion for MIE, a double-contrast esophagram or endoscopic examination shou ... Full text Link to item Cite

Primary gastrointestinal lymphoma.

Journal Article South Med J · August 1985 We studied 56 patients with primary gastrointestinal lymphoma to determine the manifestations, diagnostic and treatment methods, and patient outcomes. We identified 27 cases of primary gastric lymphoma and 29 cases of lymphoma involving the remainder of th ... Full text Link to item Cite

Gastrointestinal dysfunction in the critically ill: nutritional implications.

Journal Article Compr Ther · August 1985 Parenteral therapy is frequently indicated for initial repletion in the severely malnourished patient. Attention should be paid to the nutrients required for initial repletion based on the patient's metabolic needs at the time of therapy, as well as allowa ... Link to item Cite

Gastroduodenal ulcerations in patients receiving selective hepatic artery infusion chemotherapy.

Journal Article Am J Gastroenterol · June 1985 Ninety-three patients with liver metastases underwent selective hepatic arterial infusion of chemotherapeutic agents through a surgically implanted hepatic artery catheter and pump. Fourteen patients who developed upper gastrointestinal symptoms at some ti ... Link to item Cite

Peritoneoscopy in the management of catheter malfunction during continuous ambulatory peritoneal dialysis.

Journal Article Dig Dis Sci · May 1985 Continuous ambulatory peritoneal dialysis is widely used in the maintenance of patients with chronic renal failure. Obstruction or displacement of the chronic dialysis catheter, which prevents dialysate drainage, can compromise ongoing dialysis. Conservati ... Full text Link to item Cite

Endoscopic retrograde computed tomography of the pancreas.

Journal Article J Comput Assist Tomogr · February 1984 Endoscopic retrograde cholangiopancreatography (ERCP) and computed tomography (CT) are well established diagnostic studies for pancreatic evaluation. We conducted a study to determine whether performing these examinations in tandem increased diagnostic acc ... Full text Link to item Cite

Albumin influences sulfobromophthalein transport by hepatocytes of each acinar zone.

Journal Article Am J Physiol · January 1984 To determine whether profiles of decreasing concentration were generated among hepatocytes of the liver acinus during the transport of sulfobromophthalein sodium (BSP), rat livers were perfused with various concentrations of this dye (10 microM to 1 mM) in ... Full text Link to item Cite

Albumin influences sulfobromophthalein transport by hepatocytes of each acinar zone

Journal Article American Journal of Physiology - Gastrointestinal and Liver Physiology · January 1, 1984 To determine whether profiles of decreasing concentration were generated among hepatocytes of the liver acinus during the transport of sulfobromophthalein sodium (BSP), rat livers were perfused with various concentrations of this dye (10 μM to 1 mM) in the ... Cite

Patient selection and survival after peritoneovenous shunting for nonmalignant ascites

Journal Article American Journal of Gastroenterology · 1984 Patient selection and survival after peritoneovenous shunting for nonmalignant ascites was assessed in 30 patients undergoing 44 peritoneovenous shunting procedures over a 5-year period. Indications for peritoneovenous shunting included refractory ascites ... Cite

How good is screening for colorectal cancer?

Journal Article Postgrad Med · June 1983 Colorectal cancer is potentially preventable. Use of fecal occult blood testing, flexible sigmoidoscopy, and a combination of air-contrast barium enema examination and colonoscopy has proved to be a safe, relatively inexpensive approach to detecting colon ... Full text Link to item Cite

Pathophysiology of peptic ulcer disease

Journal Article Seminars in Family Medicine · January 1, 1980 Cite

Effect of chronic ethanol administration on small bowel brush border enzymes

Journal Article Gastroenterology · January 1, 1980 Cite