Scholars@Duke
Joseph Kamel Salama

Joseph Kamel Salama

Professor of Radiation Oncology
Radiation Oncology
Box 3085, Duke University Medical Center, Durham, NC 27710
201 Trent Drive, Box 3085, Durham, NC 27710

Selected Publications

Adaptive Radiation Therapy: Workforce Implications

Journal Article International Journal of Radiation Oncology Biology Physics · July 15, 2025 Full text Cite

Multi-institutional Outcomes after Stereotactic Radiosurgery for Gastrointestinal Brain Metastases.

Journal Article Adv Radiat Oncol · July 2025 PURPOSE: To compare outcomes between gastrointestinal and nongastrointestinal patients with brain metastases after radiosurgery. METHODS AND MATERIALS: Retrospective cohort study identifying patients completing an initial course of radiosurgery between Jan ... Full text Link to item Cite

Survival and recurrence rates following SBRT or surgery in medically operable Stage I NSCLC.

Journal Article Lung Cancer · November 2024 OBJECTIVES: Surgery is the standard of care for early-stage non-small cell lung cancer (NSCLC), with SBRT reserved for patients who are not surgical candidates. We hypothesized overall survival (OS), lung cancer-specific survival (LCSS), progression free s ... Full text Link to item Cite

Challenges and Opportunities in Developing an Oncology Clinical Trial Network in the United States Veterans Affairs Health Care System: The VA STARPORT Experience.

Journal Article Curr Oncol · August 21, 2024 The United States Veterans Affairs (VA) Health Care System has a strong history of conducting impactful oncology randomized clinical trials (RCTs). We developed a phase II/III RCT to test the use of metastasis-directed therapy in Veterans with oligometasta ... Full text Link to item Cite

Determinants of Symptomatic Intracranial Progression After an Initial Stereotactic Radiosurgery Course.

Journal Article Adv Radiat Oncol · June 2024 PURPOSE: Clinical and imaging surveillance of patients with brain metastases is important after stereotactic radiosurgery (SRS) because many will experience intracranial progression (ITCP) requiring multidisciplinary management. The prognostic significance ... Full text Link to item Cite

Current Strengths and Weaknesses of ChatGPT as a Resource for Radiation Oncology Patients and Providers.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2024 PURPOSE: Chat Generative Pre-Trained Transformer (ChatGPT), an artificial intelligence program that uses natural language processing to generate conversational-style responses to questions or inputs, is increasingly being used by both patients and health c ... Full text Link to item Cite

Radiation technique and outcomes following moderately hypofractionated treatment of low risk prostate cancer: a secondary analysis of RTOG 0415.

Journal Article Prostate Cancer Prostatic Dis · March 2024 BACKGROUND: While moderately hypofractionated radiotherapy (MHRT) for prostate cancer (PC) is commonly delivered by intensity modulated radiation therapy, IMRT has not been prospectively compared to three-dimensional conformal radiotherapy (3D-CRT) in this ... Full text Link to item Cite

In Reply to Burton and Hardcastle.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2024 Full text Link to item Cite

Incidence and imaging characteristics of difficult to detect retrospectively identified brain metastases in patients receiving repeat courses of stereotactic radiosurgery.

Journal Article J Neurooncol · March 2024 PURPOSE: During stereotactic radiosurgery (SRS) planning for brain metastases (BM), brain MRIs are reviewed to select appropriate targets based on radiographic characteristics. Some BM are difficult to detect and/or definitively identify and may go untreat ... Full text Link to item Cite

Rationale for Fractionated and Single-Session Approaches

Chapter · January 1, 2024 Stereotactic radiosurgery (SRS) delivers a high dose of radiation to an intracranial target in a single session. Modern planning capabilities and the ability to confirm and reproduce day-to-day setup positioning with on-board imaging and customized, reloca ... Full text Cite

Intracranial and Extracranial Progression and Their Correlation With Overall Survival After Stereotactic Radiosurgery in a Multi-institutional Cohort With Brain Metastases.

Journal Article JAMA Netw Open · April 3, 2023 IMPORTANCE: Clinical trials for metastatic malignant neoplasms are increasingly being extended to patients with brain metastases. Despite the preeminence of progression-free survival (PFS) as a primary oncologic end point, the correlation of intracranial p ... Full text Link to item Cite

A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2023 PURPOSE: We sought to develop a computer-aided detection (CAD) system that optimally augments human performance, excelling especially at identifying small inconspicuous brain metastases (BMs), by training a convolutional neural network on a unique magnetic ... Full text Link to item Cite

The 17-Gene Genomic Prostate Score Test Is Prognostic for Outcomes After Primary External Beam Radiation Therapy in Men With Clinically Localized Prostate Cancer.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2023 PURPOSE: The Oncotype DX Genomic Prostate Score (GPS) assay has been validated as a strong prognostic indicator of adverse pathology, biochemical recurrence, distant metastasis (DM), and prostate cancer (PCa)-related death (PCD) in men with localized PCa a ... Full text Link to item Cite

Toxicity and Outcomes of Moderately Hypofractionated Radiation for Prostate Cancer With Seminal Vesicle Involvement.

Journal Article Adv Radiat Oncol · 2023 PURPOSE: The aim of this study was to assess the toxicity and outcomes following treatment of prostate cancer with seminal vesicle involvement (SVI) evident on magnetic resonance imaging or clinical examination with moderately hypofractionated radiation th ... Full text Link to item Cite

Target Volume Delineation in Non-small Cell Lung Cancer

Chapter · January 1, 2023 Radiation therapy (RT) is an established treatment for all stages of non-small cell lung cancer (NSCLC), from definitive RT for early-stage disease to palliative RT for advanced and metastatic disease. Identifying the appropriate RT target for each patient ... Full text Cite

Role of radiation in oligometastases and oligoprogression in metastatic non-small cell lung cancer: consensus and controversy.

Journal Article Expert Rev Respir Med · 2023 INTRODUCTION: The oligometastatic state in non-small cell lung cancer (NSCLC) has recently become well-established. However, the specific definition of oligometastases remains unclear. Several smaller randomized studies have investigated the safety and eff ... Full text Link to item Cite

Clinical Outcomes Following an Initial Stereotactic Radiosurgery Course for Brain Metastases from Melanoma

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2023 Cite

ChatGPT is an Unreliable Tool for Reviewing Radiation Oncology Literature

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2023 Cite

Multi-Institutional Outcomes Following Stereotactic Radiosurgery for Gastrointestinal Brain Metastases

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2023 Cite

Evaluating the Reliability of Chat-GPT Model Responses for Radiation Oncology Patient Inquiries

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2023 Cite

Prognostic Model for Intracranial Progression after Stereotactic Radiosurgery: A Multicenter Validation Study.

Journal Article Cancers (Basel) · October 22, 2022 Stereotactic radiosurgery (SRS) is a standard of care for many patients with brain metastases. To optimize post-SRS surveillance, this study aimed to validate a previously published nomogram predicting post-SRS intracranial progression (IP). We identified ... Full text Link to item Cite

Impact of Race on Outcomes of High-Risk Patients With Prostate Cancer Treated With Moderately Hypofractionated Radiotherapy in an Equal Access Setting.

Journal Article Fed Pract · August 2022 BACKGROUND: Moderately hypofractionated radiotherapy (MHRT) is an accepted treatment for localized prostate cancer; however, limited MHRT data address high-risk prostate cancer (HRPC) and/or African American patients. We report clinical outcomes and toxici ... Full text Link to item Cite

Alliance A082002 -a randomized phase II/III trial of modern immunotherapy-based systemic therapy with or without SBRT for PD-L1-negative, advanced non-small cell lung cancer.

Journal Article Clinical lung cancer · July 2022 IntroductionTreatment of advanced stage non-small cell lung cancer (NSCLC) has changed dramatically due to immunotherapy. However, patients without Programmed Death-Ligand 1 (PD-L1) protein expression often benefit less from immunotherapy. This tr ... Full text Cite

Comparing Outcomes of Oligometastases Treated with Hypofractionated Image-Guided Radiotherapy (HIGRT) with a Simultaneous Integrated Boost (SIB) Technique versus Metastasis Alone: A Multi-Institutional Analysis.

Journal Article Cancers (Basel) · May 13, 2022 PURPOSE: We previously reported on the clinical outcomes of treating oligometastases with radiation using an elective simultaneous integrated boost technique (SIB), delivering higher doses to known metastases and reduced doses to adjacent bone or nodal bas ... Full text Link to item Cite

Nomogram Predicting Overall Survival Benefit of Stereotactic Ablative Radiotherapy for Early-Stage Non-Small Cell Lung Cancer.

Journal Article Clin Lung Cancer · March 2022 OBJECTIVES: To develop and validate a nomogram that predicts overall survival (OS) for patients with early-stage non-small cell lung cancer (NSCLC) treated with stereotactic ablative radiotherapy (SABR) vs. observation. MATERIALS AND METHODS: Adults with b ... Full text Link to item Cite

Radiation technique and outcomes following moderately hypofractionated treatment of low risk prostate cancer: A secondary analysis of the NRG oncology RTOG 0415 randomized clinical trial.

Conference Journal of Clinical Oncology · February 20, 2022 243 Background: While intensity-modulated radiotherapy (IMRT) is commonly used to deliver moderately hypofractionated radiotherapy (MHRT) for prostate cancer (PC), IMRT has not been prospectively compared to three-dimensional con ... Full text Cite

Veterans affairs seamless phase II/III randomized trial of standard systemic therapy with or without PET-directed local therapy for oligorecurrent prostate cancer (VA STARPORT).

Conference Journal of Clinical Oncology · February 20, 2022 TPS203 Background: Two diverging paradigms have been studied in recent years to improve the survival of men with recurrent metastatic prostate cancer (PCa). First, multiple recent phase II randomized trials have demonstrated impr ... Full text Cite

Effect of Large Prostate Volume on Efficacy and Toxicity of Moderately Hypofractionated Radiation Therapy in Patients With Prostate Cancer.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: To evaluate the effect of prostate volume on outcomes after moderately hypofractionated radiation therapy (mHFRT) for prostate cancer. METHODS AND MATERIALS: Prostate cancer patients treated with mHFRT at a Veteran's Affairs Medical Center from Au ... Full text Link to item Cite

A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases (BM)

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2022 Cite

Dosimetric Predictors of Toxicity in Patients With Early-Stage Prostate Cancer Treated With Moderately Hypofractionated IMRT or PBT: A Multi-Institutional Analysis.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Limited published data address modifiable risk factors for significant toxicity complicating moderately hypofractionated schedules of intensity-modulated radiation therapy (IMRT) and proton-beam therapy (PBT) in patients with e ... Full text Cite

Oligometastases Treated With an Elective Simultaneous Integrated Boost Have Reduced Marginal Recurrence Rates.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Radiation is increasingly used to treat oligometastatic patients (OM). Following metastasis directed radiation therapy, progression in nearby nodal basins or bones is common. We previously reported clinical outcomes of OM treat ... Full text Cite

The Role of Hypofractionated Radiation Therapy in the Management of Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Management of HCC without surgical resection or transplantation is poorly defined with no standard. Stereotactic body radiation therapy (SBRT) or hypofractionated image-guided radiotherapy (HIGRT), is an evolving, non-invasive, ... Full text Cite

Toxicity and Dosimetric Parameters of Ablative Radiation Therapy in the Management of Patients with Child-Pugh B/C Liver Function and Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)To date there is no clear standard non-surgical therapeutic option for HCC patients. Ablative radiation therapy (SBRT/HIGRT) is an emerging non-invasive treatment for patients with HCC. However, there is concern about the risk ... Full text Cite

Veliparib in combination with carboplatin/paclitaxel-based chemoradiotherapy in patients with stage III non-small cell lung cancer.

Journal Article Lung Cancer · September 2021 OBJECTIVES: Veliparib is a potent poly(ADP)-ribose polymerase (PARP) 1 and 2 inhibitor that impedes repair of DNA damage induced by cytotoxic and radiation therapies. This phase 1 study evaluated veliparib in combination with chemoradiotherapy in patients ... Full text Link to item Cite

A Pooled Toxicity Analysis of Moderately Hypofractionated Proton Beam Therapy and Intensity Modulated Radiation Therapy in Early-Stage Prostate Cancer Patients.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2021 PURPOSE: Data comparing moderately hypofractionated intensity modulated radiation therapy (IMRT) and proton beam therapy (PBT) are lacking. We aim to compare late toxicity profiles of patients with early-stage prostate cancer treated with moderately hypofr ... Full text Link to item Cite

Fostering Radiation Oncology Physician Scientist Trainees Within a Diverse Workforce: The Radiation Oncology Research Scholar Track.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2021 There is a need to foster future generations of radiation oncology physician scientists, but the number of radiation oncologists with sufficient education, training, and funding to make transformative discoveries is relatively small. A large number of MD/P ... Full text Open Access Link to item Cite

Evaluation of Safety of Stereotactic Body Radiotherapy for the Treatment of Patients With Multiple Metastases: Findings From the NRG-BR001 Phase 1 Trial.

Journal Article JAMA Oncol · June 1, 2021 IMPORTANCE: Stereotactic body radiotherapy (SBRT) for oligometastases is hypothesized to improve survival and is increasingly used. Little evidence supports its safe use to treat patients with multiple metastases. OBJECTIVE: To establish safety of SBRT dos ... Full text Link to item Cite

Integration of immunotherapy into adjuvant therapy for resected non-small-cell lung cancer: ALCHEMIST chemo-IO (ACCIO).

Journal Article Immunotherapy · June 2021 Non-small-cell lung cancer (NSCLC) causes significant mortality each year. After successful resection of disease stage IB (>4 cm) to IIIA (per AJCC 7), adjuvant platinum-based chemotherapy improves median overall survival and is the standard of care, but m ... Full text Link to item Cite

Oligometastatic breast cancer: where are we now and where are we headed?-a narrative review.

Journal Article Ann Palliat Med · May 2021 Metastatic breast cancer has traditionally been considered incurable, with treatments focused on systemic therapies and palliative local treatment. However, evidence is emerging that in some patients with limited metastatic disease, or "oligometastatic dis ... Full text Link to item Cite

Synergy between early-incorporation immunotherapy and extracranial radiotherapy in metastatic non-small cell lung cancer.

Journal Article Transl Lung Cancer Res · January 2021 BACKGROUND: Combining radiotherapy (RT) and immunotherapy (IT) may enhance outcomes for metastatic non-small cell lung cancer (mNSCLC). However, data on the immunomodulatory effects of extracranial RT remains limited. This retrospective database analysis e ... Full text Link to item Cite

Effective Pain Control With Very Low Dose Palliative Radiation Therapy for Patients With Multiple Myeloma With Uncomplicated Osseous Lesions.

Journal Article Adv Radiat Oncol · 2021 BACKGROUND: Osteolytic lesions are present in 75% of patients with multiple myeloma (MM) and frequently require palliation with radiation therapy (RT). Prior case series of patients with MM with bone pain undergoing palliative RT suggests doses ≥12 Gy (equ ... Full text Link to item Cite

Improved Survival Associated with Local Tumor Response Following Multisite Radiotherapy and Pembrolizumab: Secondary Analysis of a Phase I Trial.

Journal Article Clin Cancer Res · December 15, 2020 PURPOSE: Multisite stereotactic body radiotherapy followed by pembrolizumab (SBRT+P) has demonstrated safety in advanced solid tumors (ASTs). However, no studies have examined the relationships between irradiated tumor response, SBRT-induced tumor gene exp ... Full text Link to item Cite

Development and Implementation of an Educational Simulation Workshop in Fiberoptic Laryngoscopy for Radiation Oncology Residents.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2020 PURPOSE: Fiberoptic laryngoscopy (FOL) is a critical tool for the diagnosis, staging, assessment of treatment response, and detection of recurrence for head and neck (H&N) malignancies. No standardized recommendations exist for procedural FOL education in ... Full text Link to item Cite

Abdominal and pelvic adipose tissue distribution and risk of prostate cancer recurrence after radiation therapy.

Journal Article Prostate · October 2020 BACKGROUND: Fat distribution varies between individuals of similar body mass index (BMI). We hypothesized that visceral obesity is more strongly associated with poor prostate cancer outcomes than overall obesity defined by BMI. MATERIALS AND METHODS: We qu ... Full text Link to item Cite

Current multidisciplinary management of brain metastases.

Journal Article Cancer · April 1, 2020 Brain metastasis (BM), the most common adult brain tumor, develops in 20% to 40% of patients with late-stage cancer and traditionally are associated with a poor prognosis. The management of patients with BM has become increasingly complex because of new an ... Full text Link to item Cite

Oligoreview of Non-Small Cell Lung Cancer Oligometastases.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2020 Full text Link to item Cite

Survival Advantage With Adjuvant Chemotherapy for Locoregionally Advanced Rectal Cancer: A Veterans Health Administration Analysis.

Journal Article Journal of the National Comprehensive Cancer Network : JNCCN · January 2020 BackgroundAdjuvant chemotherapy (AC) after chemoradiation (CRT) and surgery for locoregionally advanced rectal cancer (LARC) is a standard of care in the United States. This study examined the role, optimal regimen, and duration of AC using data f ... Full text Cite

Local Tumor Control and Patient Outcome Using Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: iRECIST as a Potential Substitute for Traditional Criteria.

Journal Article AJR Am J Roentgenol · December 2019 OBJECTIVE. The purpose of this study was to investigate whether, compared with traditional criteria, the modified Response Evaluation Criteria in Solid Tumors version 1.1 for immune-based therapeutics (iRECIST) improves prediction of local tumor control an ... Full text Link to item Cite

Salvage Radiotherapy for Recurrent Prostate Cancer: Can the Prognostic Grade Group System Inform Treatment Timing?

Journal Article Clin Genitourin Cancer · October 2019 PURPOSE: In order to better time salvage radiotherapy (SRT) for post-radical prostatectomy biochemical failure, we examined the association between pre-SRT prostate-specific antigen (PSA) and PSA control as a function of the new prognostic grade group (PGG ... Full text Link to item Cite

Retrospective analysis of safety and efficacy of anti-PD-1 therapy and radiation therapy in advanced melanoma: A bi-institutional study.

Journal Article Radiother Oncol · September 2019 BACKGROUND AND PURPOSE: Antibodies against programmed cell death protein 1 (PD-1) are standard treatments for advanced melanoma. Palliative radiation therapy (RT) is commonly administered for this disease. Safety and optimal timing for this combination for ... Full text Link to item Cite

Authors' Reply.

Journal Article J Natl Compr Canc Netw · August 1, 2019 Full text Link to item Cite

NRG-BR002: A phase IIR/III trial of standard of care therapy with or without stereotactic body radiotherapy (SBRT) and/or surgical ablation for newly oligometastatic breast cancer (NCT02364557).

Conference Journal of Clinical Oncology · May 20, 2019 TPS1117 Background: This is a randomized Phase II/III trial to evaluate if stereotactic body radiotherapy (SBRT) and/or surgical resection (SR) of all metastatic sites in newly oligo-metastatic breast cancer who have received up ... Full text Cite

A Nomogram for Testosterone Recovery After Combined Androgen Deprivation and Radiation Therapy for Prostate Cancer.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2019 PURPOSE: Testosterone recovery (TR) after androgen deprivation therapy (ADT) and radiation therapy (RT) is not well characterized. We studied TR in men who received RT and either short-term ADT (STADT) or long-term ADT (LTADT) and aimed to create a nomogra ... Full text Link to item Cite

Long-term Clinical Outcomes of Nonoperative Management With Chemoradiotherapy for Locally Advanced Rectal Cancer in the Veterans Health Administration.

Journal Article International journal of radiation oncology, biology, physics · March 2019 PurposeStandard therapy for locally advanced rectal cancer includes neoadjuvant chemoradiation and surgery. Complete response (CR) rates after chemoradiation can be as high as 29%, suggesting that nonoperative management (NOM) may be reasonable wi ... Full text Cite

Increasing PET Use in Small Cell Lung Cancer: Survival Improvement and Stage Migration in the VA Central Cancer Registry.

Journal Article Journal of the National Comprehensive Cancer Network : JNCCN · February 2019 Background: Accurate staging for small cell lung cancer (SCLC) is critical for determining appropriate therapy. The clinical impact of increasing PET adoption and stage migration is well described in non-small cell lung cancer but not in SCLC. The o ... Full text Cite

Nonuniform Planning Target Volume Margins for Prostate Bed on the Basis of Surgical Clips on Daily Cone Beam Computed Tomography.

Journal Article Adv Radiat Oncol · 2019 PURPOSE: We hypothesized that the interfraction motions of the superior and inferior prostate beds differ and therefore require different margins. In this study, we used daily cone beam computed tomography (CBCT) to evaluate the motion of postprostatectomy ... Full text Open Access Link to item Cite

Knowledge-Based Statistical Inference Method for Plan Quality Quantification.

Journal Article Technol Cancer Res Treat · January 1, 2019 AIM: The aim of the study is to develop a geometrically adaptive and statistically robust plan quality inference method. METHODS AND MATERIALS: We propose a knowledge-based plan quality inference method that references to similar plans in the historical da ... Full text Open Access Link to item Cite

Hypofractionated Image-Guided Radiation Therapy With Simultaneous-Integrated Boost Technique for Limited Metastases: A Multi-Institutional Analysis.

Journal Article Front Oncol · 2019 Purpose: To perform a multi-institutional analysis following treatment of limited osseous and/or nodal metastases in patients using a novel hypofractionated image-guided radiotherapy with simultaneous-integrated boost (HIGRT-SIB) technique. Methods: Consec ... Full text Open Access Link to item Cite

Radiation Therapy for Pancreatic Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.

Journal Article Pract Radiat Oncol · 2019 PURPOSE: This guideline systematically reviews the evidence for treatment of pancreatic cancer with radiation in the adjuvant, neoadjuvant, definitive, and palliative settings and provides recommendations on indications and technical considerations. METHOD ... Full text Link to item Cite

Predicting intracranial progression following stereotactic radiosurgery for brain metastases: Implications for post SRS imaging.

Journal Article J Radiosurg SBRT · 2019 PURPOSE: Follow-up imaging after stereotactic radiosurgery (SRS) is crucial to identify salvageable brain metastases (BM) recurrence. As optimal imaging intervals are poorly understood, we sought to build a predictive model for time to intracranial progres ... Link to item Cite

The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.

Journal Article J Radiosurg SBRT · 2019 PURPOSE: Single-isocenter multi-target (SIMT) volumetric modulated arc therapy (VMAT) is primarily limited to linear accelerators utilizing 2.5 mm leaf width MLCs. We explore feasibility of applying this technique to linear accelerators utilizing MLCs with ... Open Access Link to item Cite

The multidisciplinary management of early-stage cervical esophageal cancer

Chapter · January 1, 2019 Cervical esophageal cancer (CEC) was historically treated with primary surgery, typically a pharyngo-laryngo-esophagectomy (PLE), a morbid procedure with substantial impact on a patient’s long-term quality of life. More recently, a paradigm shift has occur ... Full text Cite

Phase I Trial of Stereotactic Body Radiation Therapy (SBRT) to Multiple Metastatic Sites: A NRG Oncology Study

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

Modeling and Prediction of SIB Prostate IMRT Plans

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

Patient Factors Predicting Intracranial Progression: Optimizing MRI Surveillance Interval Following Brain Metastases SRS

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

Postoperative Radiation Therapy for Prostate Cancer: Comparison of Conventional Versus Hypofractionated Radiation Regimens.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2018 PURPOSE: To compare acute/late toxicity and biochemical control in contemporaneous prostate cancer patient cohorts treated with hypofractionated postprostatectomy radiation therapy (hypoPORT) or conventional PORT (coPORT). METHODS AND MATERIALS: Consecutiv ... Full text Link to item Cite

Radiation toxicities and management

Chapter · March 19, 2018 Cite

Role of adjuvant chemotherapy following chemoradiation and surgery for locoregionally advanced rectal cancer: A Veterans Health Administration analysis.

Conference Journal of Clinical Oncology · February 1, 2018 741 Background: Adjuvant chemotherapy (AC) following chemoradiation (CRT) and total mesorectal excision (TME) for locoregionally advanced rectal cancer (LARC) is a standard of care in the United States despite limited data. The p ... Full text Cite

Managing Patients With Oligometastatic Non-Small-Cell Lung Cancer.

Journal Article J Oncol Pract · January 2018 Metastatic lung cancer has long been considered incurable, with the goal of treatment being palliation. However, a clinically meaningful number of these patients with limited metastases (approximately 25%) are living long term after definitive treatment to ... Full text Link to item Cite

Classification for long-term survival in oligometastatic patients treated with ablative radiotherapy: A multi-institutional pooled analysis.

Journal Article PLoS One · 2018 BACKGROUND: Radiotherapy is increasingly used to treat oligometastatic patients. We sought to identify prognostic criteria in oligometastatic patients undergoing definitive hypofractionated image-guided radiotherapy (HIGRT). METHODS: Exclusively extracrani ... Full text Link to item Cite

Oral cavity cancer: Diagnosis and treatment

Chapter · January 1, 2018 A comprehensive history, thorough head and neck physical examination, and adequate staging are critical to guide optimal locoregional treatment and evaluate for second primaries in patients with oral cavity cancer. A multidisciplinary approach-including he ... Full text Cite

Oral Cavity Cancer: Diagnosis and Treatment

Chapter · January 1, 2018 A comprehensive history, thorough head and neck physical examination, and adequate staging are critical to guide optimal locoregional treatment and evaluate for second primaries in patients with oral cavity cancer. A multidisciplinary approach-including he ... Full text Cite

Improved Survival of Stage I Non-Small Cell Lung Cancer: A VA Central Cancer Registry Analysis.

Journal Article Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · December 2017 IntroductionThe combined impact of advances in diagnosis and treatment of stage I NSCLC has not been assessed comprehensively. To define the survival impact of modern staging and treatment techniques for clinical stage I NSCLC, the Veterans Admini ... Full text Cite

Metastasis-Directed Therapy: Right for Some, but Not All, and Not Here.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2017 Full text Link to item Cite

The Impact of Biologically Equivalent Dose on Tumor Control in Unresectable Hepatocellular Carcinoma

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Once Versus Twice Daily Fractionation for Limited Stage SCLC

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Non-operative Management for Locally Advanced Rectal Cancer in the Veterans Health Administration

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Definitive Stereotactic Body Radiotherapy (SBRT) for Extracranial Oligometastases: An International Survey of >1000 Radiation Oncologists.

Journal Article Am J Clin Oncol · August 2017 PURPOSE: Stereotactic body radiotherapy (SBRT) is often used to treat patients with oligometastases (OM). Yet, patterns of SBRT practice for OM are unknown. Therefore, we surveyed radiation oncologists internationally, to understand how and when SBRT is us ... Full text Link to item Cite

Tolerability of veliparib (V) in combination with carboplatin (C)/paclitaxel (P): Based chemoradiotherapy (CRT) in subjects with stage III non-small cell lung cancer (NSCLC).

Conference Journal of Clinical Oncology · May 20, 2017 8546 Background: CRT is a standard for patients with Stage III NSCLC. V is a potent, orally bioavailable PARP1/2 inhibitor that can delay DNA repair following chemotherapy or radiation induced damage. A Phase 2 study indicated fa ... Full text Cite

Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States.

Journal Article Cancer · April 15, 2017 BACKGROUND: Short-course radiotherapy (SC-RT) and long-course chemoradiotherapy (LC-CRT) are accepted neoadjuvant treatments of rectal cancer. In the current study, the authors surveyed US radiation oncologists to assess practice patterns and attitudes reg ... Full text Link to item Cite

ACR appropriateness criteria® nasal cavity and paranasal sinus cancers.

Journal Article Head Neck · March 2017 The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive anal ... Full text Link to item Cite

A nomogram for testosterone recovery following combined androgen deprivation therapy and radiation therapy for prostate cancer.

Conference Journal of Clinical Oncology · February 20, 2017 67 Background: Combined androgen deprivation therapy (ADT) and radiation therapy (RT) is a frequently used localized prostate cancer (PC) treatment. Testosterone recovery (TR) after combined ADT-RT is not well-characterized. We s ... Full text Cite

Abstract OT1-04-06: NRG-BR002: A phase IIR/III trial of standard of care therapy with or without stereotactic body radiotherapy (SBRT) &/or surgical ablation for newly oligometastatic breast cancer

Conference Cancer Research · February 15, 2017 AbstractBackground:The current standard of care for metastatic breast cancer patients (pts) is to deliver palliative chemotherapy, biologic &/or hormonal therapy when app ... Full text Cite

Patterns of Distant Metastases After Surgical Management of Non-Small-cell Lung Cancer.

Journal Article Clin Lung Cancer · January 2017 BACKGROUND: Patients with limited metastases, oligometastases (OMs), might have improved outcomes compared with patients with widespread distant metastases (DMs). The incidence and behavior of OMs from non-small-cell lung cancer (NSCLC) need further charac ... Full text Link to item Cite

Benchmark Credentialing Results for NRG-BR001: The First National Cancer Institute-Sponsored Trial of Stereotactic Body Radiation Therapy for Multiple Metastases.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2017 PURPOSE: The NRG-BR001 trial is the first National Cancer Institute-sponsored trial to treat multiple (range 2-4) extracranial metastases with stereotactic body radiation therapy. Benchmark credentialing is required to ensure adherence to this complex prot ... Full text Link to item Cite

The expanding role of stereotactic body radiation therapy in oligometastatic solid tumors: What do we know and where are we going?

Journal Article Cancer Treat Rev · January 2017 The spectrum hypothesis posits that there are distinct clinical states of metastatic progression. Early data suggest that aggressive treatment of more biologically indolent metastatic disease, characterized by metastases limited in number and destination o ... Full text Link to item Cite

Triphasic contrast enhanced CT simulation with bolus tracking for pancreas SBRT target delineation.

Journal Article Pract Radiat Oncol · 2017 PURPOSE: Bolus-tracked multiphasic contrast computed tomography (CT) is often used in diagnostic radiology to enhance the visibility of pancreas tumors, but is uncommon in radiation therapy pancreas CT simulation, and its impact on gross tumor volume (GTV) ... Full text Link to item Cite

Radiotherapy for Oligometastatic Lung Cancer.

Journal Article Front Oncol · 2017 Non-small cell lung cancer (NSCLC) typically presents at an advanced stage, which is often felt to be incurable, and such patients are usually treated with a palliative approach. Accumulating retrospective and prospective clinical evidence, including a rec ... Full text Link to item Cite

The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: The optimal approach to patients with locally recurrent, non-metastatic rectal cancer is unclear. This study evaluates the outcomes and toxicity associated with pelvic re-irradiation. METHODS: Patients undergoing re-irradiation for locally recu ... Full text Link to item Cite

Impact of Race on Treatment and Survival among U.S. Veterans with Early-Stage Lung Cancer.

Journal Article Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · October 2016 IntroductionNumerous reports suggest lower rates of surgical procedures and poorer survival for black patients with early-stage (stage I or II) NSCLC than for white patients. This study examined treatment trends among blacks and whites with early- ... Full text Cite

Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2016 PURPOSE: To test whether oxygenation kinetics correlate with the likelihood for local tumor control after fractionated radiation therapy. METHODS AND MATERIALS: We used diffuse reflectance spectroscopy to noninvasively measure tumor vascular oxygenation an ... Full text Link to item Cite

The Use of Reirradiation in Locally Recurrent, Nonmetastatic Rectal Cancer.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2016 Full text Link to item Cite

Toxicity and Survival for Metastatic Melanoma Patients Treated With Anti-PD1 Therapy and Radiation Treatment

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · October 1, 2016 Link to item Cite

ACR Appropriateness Criteria(®) Locoregional therapy for resectable oropharyngeal squamous cell carcinomas.

Journal Article Head Neck · September 2016 BACKGROUND: There are no level I studies to guide treatment for resectable oropharyngeal squamous cell carcinoma (SCC). Treatment toxicities influence management recommendations. Ongoing investigations are examining deintensified treatments for human papil ... Full text Link to item Cite

Safety and Efficacy of Radiation Therapy in Advanced Melanoma Patients Treated With Ipilimumab.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2016 PURPOSE: Ipilimumab and radiation therapy (RT) are standard treatments for advanced melanoma; preclinical models suggest the potential for synergy. However, limited clinical information exists regarding safety and optimal timing of the combination. METHODS ... Full text Link to item Cite

Final Results of a Randomized Phase 2 Trial Investigating the Addition of Cetuximab to Induction Chemotherapy and Accelerated or Hyperfractionated Chemoradiation for Locoregionally Advanced Head and Neck Cancer.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2016 PURPOSE: The role of cetuximab in the treatment of locoregionally advanced head and neck squamous cell cancer (LA-HNSCC) remains poorly defined. In this phase 2 randomized study, we investigated the addition of cetuximab to both induction chemotherapy (IC) ... Full text Link to item Cite

Outcomes and toxicity of stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab.

Journal Article Melanoma Manag · September 2016 PURPOSE: Patients with melanoma treated with ipilimumab and radiosurgery (stereotactic radiosurgery [SRS]) were reviewed for efficacy/safety. METHODS: Patients who received ipilimumab and SRS for brain metastases were analyzed for control of SRS-treated me ... Full text Link to item Cite

Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer.

Journal Article Lung Cancer · August 2016 To determine the feasibility and toxicity of radiation therapy, delivered either as definitive treatment or following surgery, following neo-adjuvant immune checkpoint inhibition for locally advanced NSCLC sixteen patients who received neo-adjuvant chemoth ... Full text Link to item Cite

Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT).

Journal Article Cancer · July 15, 2016 BACKGROUND: The selection of patients for oligometastasis-directed ablative therapy remains a challenge. The authors report on clinical and molecular predictors of survival from a stereotactic body radiotherapy (SBRT) dose-escalation trial for oligometasta ... Full text Link to item Cite

ACR Appropriateness criteria® for nasopharyngeal carcinoma.

Journal Article Head Neck · July 2016 BACKGROUND: Nasopharyngeal carcinoma (NPC) presents mostly with locally advanced disease and is treated with multimodal therapy; however, consensus is lacking for different clinical scenarios. METHODS: The American College of Radiology (ACR) Appropriatenes ... Full text Link to item Cite

Irradiation and immunotherapy: From concept to the clinic.

Journal Article Cancer · June 1, 2016 In recent years, an increased understanding of T-cell-regulatory mechanisms has led to the development of a novel class of immune-checkpoint inhibitors that have robust clinical activity against a broad array of malignancies-even those that historically we ... Full text Link to item Cite

Stereotactic body radiotherapy for oligometastatic breast cancer: a new standard of care, or a medical reversal in waiting?

Journal Article Expert Rev Anticancer Ther · June 2016 Metastases-directed therapy via surgery or stereotactic body radiotherapy (SBRT) has become the de facto standard of care in the United States and abroad despite a lack of high quality prospective, randomized trials. Oligometastatic tumors may behave in an ... Full text Link to item Cite

In Reply to Fiorino and Cozzarini.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2016 Full text Link to item Cite

Positive Interaction between Prophylactic Cranial Irradiation and Maintenance Sunitinib for Untreated Extensive-Stage Small Cell Lung Cancer Patients After Standard Chemotherapy: A Secondary Analysis of CALGB 30504 (ALLIANCE).

Journal Article J Thorac Oncol · March 2016 BACKGROUND: Prophylactic cranial irradiation (PCI) has become a standard option for patients with extensive-stage small cell lung cancer (ES-SCLC). The Cancer and Leukemia Group B 30504 trial was a randomized phase II study of the effect of sunitinib versu ... Full text Link to item Cite

Image Guided Hypofractionated Postprostatectomy Intensity Modulated Radiation Therapy for Prostate Cancer.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2016 PURPOSE: Hypofractionated radiation therapy (RT) has promising long-term biochemical relapse-free survival (bRFS) with comparable toxicity for definitive treatment of prostate cancer. However, data reporting outcomes after adjuvant and salvage postprostate ... Full text Link to item Cite

Abstract OT3-03-04: NRG-BR002: A phase IIR/III trial of standard of care therapy with or without stereotactic body radiotherapy (SBRT) &/or surgical ablation for newly oligometastatic breast cancer

Conference Cancer Research · February 15, 2016 AbstractBackground:The current standard of care for metastatic breast cancer patients (pts) is to deliver palliative chemotherapy, biologic &/or hormonal therapy when app ... Full text Cite

Ablative Approaches for Pulmonary Metastases.

Journal Article Thorac Surg Clin · February 2016 Pulmonary metastases are common in patients with cancer for which surgery is considered a standard approach in appropriately selected patients. A number of patients are not candidates for surgery due to a medical comorbidities or the extent of surgery requ ... Full text Link to item Cite

ACR Appropriateness Criteria(®) Aggressive Nonmelanomatous Skin Cancer of the Head and Neck.

Journal Article Head Neck · February 2016 BACKGROUND: Aggressive nonmelanomatous skin cancer (NMSC) of the head and neck presents an increasingly common therapeutic challenge for which prospective clinical trials are lacking. METHODS: The American College of Radiology Appropriateness Criteria are ... Full text Link to item Cite

Dose escalation for unresectable locally advanced non-small cell lung cancer: end of the line?

Journal Article Transl Lung Cancer Res · February 2016 Radiation Therapy Oncology Group (RTOG) 0617 was a randomized trial that investigated both the impact of radiation dose-escalation and the addition of cetuximab on the treatment of non-small cell lung cancer (NSCLC). The results of RTOG 0617 were surprisin ... Full text Link to item Cite

Physics considerations for single-isocenter, volumetric modulated arc radiosurgery for treatment of multiple intracranial targets.

Conference Pract Radiat Oncol · 2016 OBJECTIVE: Our purpose was to address challenges associated with single-isocenter radiosurgery for multiple intracranial targets (SIRMIT) including increased sensitivity to rotational uncertainties (resulting from distance of the targets from isocenter) as ... Full text Link to item Cite

Rationale of technical requirements for NRG-BR001: The first NCI-sponsored trial of SBRT for the treatment of multiple metastases.

Journal Article Pract Radiat Oncol · 2016 INTRODUCTION: In 2014, the NRG Oncology Group initiated the first National Cancer Institute-sponsored, phase 1 clinical trial of stereotactic body radiation therapy (SBRT) for the treatment of multiple metastases in multiple organ sites (BR001; NCT02206334 ... Full text Link to item Cite

Stereotactic Body Radiotherapy for Oligometastasis: Opportunities for Biology to Guide Clinical Management.

Journal Article Cancer J · 2016 Oligometastasis refers to a state of limited metastatic disease burden, in which surgical or ablative treatment to all known visible metastases holds promise to extend survival or even effect cure. Stereotactic body radiotherapy is a form of radiation trea ... Full text Link to item Cite

Radiosurgery for Brain Metastases in Melanoma Patients Receiving Ipilimumab

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

Long-term Survivors of an SBRT Dose-Escalation Study for Oligometastases: Clinical and Molecular Markers

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

Benchmark Credentialing Results for the First Multiple Metastases SBRT Protocol: NRG BR001

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

Radiation therapy for oligometastatic non-small cell lung cancer.

Journal Article Cancer Metastasis Rev · June 2015 Interest has been increasing in the treatment of non-small cell lung cancer (NSCLC) patients with limited or oligometastatic disease. Surgery has historically been used to remove non-small cell lung cancer metastases, but recent developments including adva ... Full text Link to item Cite

Prophylactic cranial irradiation in elderly patients with small cell lung cancer: findings from a North Central Cancer Treatment Group pooled analysis.

Journal Article J Geriatr Oncol · March 2015 OBJECTIVES: To examine the efficacy of prophylactic cranial irradiation (PCI) in elderly patients with small cell lung cancer (SCLC) (≥70 years of age) from a pooled analysis of four prospective trials. MATERIALS & METHODS: One hundred fifty-five patients ... Full text Link to item Cite

Statin use is associated with decreased prostate cancer recurrence in men treated with brachytherapy.

Journal Article World J Urol · January 2015 PURPOSE/OBJECTIVE(S): Recent in vitro and in vivo evidence has suggested that statin medications may have anticancer activity. We sought to determine whether statin use was associated with improved clinical outcome in men treated with brachytherapy for pro ... Full text Link to item Cite

Surgery or ablative radiotherapy for breast cancer oligometastases.

Journal Article Am Soc Clin Oncol Educ Book · 2015 Precisely focused radiation or surgical resection of limited metastases resulted in long-term disease control and survival in multiple studies of patients with oligometastatic breast cancer. The integration of these ablative techniques into standard system ... Full text Link to item Cite

The multidisciplinary management 11 of early stage cervical esophageal cancer

Chapter · January 1, 2015 Cancer development in the cervical portion of the esophagus presents a unique challenge to management given the close proximity of critical structures in the head and neck. Cervical esophageal cancer (CEC) was historically approached with primarysurgery, p ... Full text Cite

The evolving role of radiotherapy in treatment of oligometastatic NSCLC.

Journal Article Expert Rev Anticancer Ther · 2015 Non-small cell lung cancer (NSCLC) patients with metastases limited in site and number, termed oligometastases, may represent a unique subpopulation of advanced NSCLC with improved prognosis. The optimal management of these patients remains unclear with th ... Full text Link to item Cite

Stereotactic treatment for oligometastatic breast cancer

Chapter · January 1, 2015 Although uncommon, a small number of patients with radiographically evident and/or biopsy-proven metastatic breast cancer are alive and disease-free more than 10 years following cytotoxic systemic therapy alone. This realization that a long-term disease-fr ... Full text Cite

The role of surgery and ablative radiotherapy in oligometastatic breast cancer.

Journal Article Semin Oncol · December 2014 The ability to deliver precise focused radiation, combined with improved surgical techniques, has led to multiple reports of long-term survivors in patients with oligometastatic breast cancer. The removal or ablation of known metastases, often present afte ... Full text Link to item Cite

Racial differences in adipose tissue distribution and risk of aggressive prostate cancer among men undergoing radiotherapy.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2014 BACKGROUND: Although elevated body mass index (BMI) has been associated with increased risk of aggressive prostate cancer, the importance of adipose tissue distribution is not well understood. We examined associations between overall and visceral obesity a ... Full text Link to item Cite

When is a biopsy-proven diagnosis necessary before stereotactic ablative radiotherapy for lung cancer?: A decision analysis.

Journal Article Chest · October 2014 BACKGROUND: The practice of treating a solitary pulmonary nodule (SPN) suspicious for stage I non-small cell lung cancer (NSCLC) with stereotactic ablative radiotherapy (SABR) in the absence of pathology is growing. In the absence of randomized evidence, t ... Full text Link to item Cite

Radical irradiation of extracranial oligometastases.

Journal Article J Clin Oncol · September 10, 2014 Advances in radiotherapy planning and delivery have been used to treat patients with limited metastatic disease. With these techniques, high rates of treated metastasis control and low toxicity have been reported. Some patients have long disease-free inter ... Full text Link to item Cite

The oligometastatic state - separating truth from wishful thinking.

Journal Article Nat Rev Clin Oncol · September 2014 The oligometastatic paradigm implies that patients who develop a small number of metastatic lesions might achieve long-term survival if all these lesions are ablated with surgery or stereotactic radiotherapy. Clinical data indicate that the number of patie ... Full text Link to item Cite

A Multi-institution Pooled Analysis of Oligometastatic Patients Treated With SBRT

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

ACR Appropriateness Criteria® thyroid carcinoma.

Journal Article Oral Oncol · June 2014 The ACR Head and Neck Cancer Appropriateness Criteria Committee reviewed relevant medical literature to provide guidance for those managing patients with thyroid carcinoma. The American College of Radiology Appropriateness Criteriaare evidence-based guidel ... Full text Link to item Cite

Stereotactic body radiotherapy: a critical review for nonradiation oncologists.

Journal Article Cancer · April 1, 2014 Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate de ... Full text Link to item Cite

Palliative radiotherapy for prostate cancer.

Journal Article Oncology (Williston Park) · April 2014 Radiotherapy is an effective tool for the palliation of symptoms commonly caused by prostate cancer. The majority of painful bone metastases respond equally well to single or multiple fractions of external radiotherapy. Retreatment with a second course of ... Link to item Cite

Palliative radiotherapy for prostate cancer.

Journal Article Oncology (Williston Park, N.Y.) · January 1, 2014 Radiotherapy is an effective tool for the palliation of symptoms commonly caused by prostate cancer. The majority of painful bone metastases respond equally well to single or multiple fractions of external radiotherapy. Retreatment with a second course of ... Cite

A paucity of practicality puts photons ahead of protons

Journal Article Clinical Advances in Hematology and Oncology · January 1, 2014 Cite

Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control.

Journal Article J Radiosurg SBRT · 2014 We analyzed factors associated with inferior local control following stereotactic ablative body radiotherapy (SABR) for palliation of metastases. We reviewed records of patients receiving SABR for metastases at Duke University from 2006-2010. Biologically ... Link to item Cite

American College of Radiology Appropriateness Criteria(®) treatment of stage I T1 glottic cancer.

Journal Article Head Neck · January 2014 BACKGROUND: Controversy surrounds the appropriate therapy for T1 glottic cancer. Both transoral endolaryngeal resection and radiation offer excellent local control and voice quality; some lesions are best addressed with resection and others with radiation. ... Full text Link to item Cite

Stereotactic body radiotherapy for the treatment of oligometastatic renal cell carcinoma.

Journal Article Am J Clin Oncol · December 2013 OBJECTIVES: Renal cell carcinoma (RCC) is considered radioresistant, but stereotactic radiosurgery can control intracranial metastases. Advances in radiotherapy, such as stereotactic body radiotherapy (SBRT), allow high-dose radiation delivery to extracran ... Full text Link to item Cite

Predictors of pulmonary toxicity in limited stage small cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904.

Journal Article Lung Cancer · December 2013 INTRODUCTION: Standard therapy for limited stage small cell lung cancer (L-SCLC) is concurrent chemotherapy and radiotherapy followed by prophylactic cranial radiotherapy. Predictors of post chemoradiotherapy pulmonary toxicity in limited stage (LS) small ... Full text Link to item Cite

Cell Cycle Progression (CCP) Score Significantly Predicts PSA Failure After EBRT

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy.

Journal Article Oral Oncol · October 2013 BACKGROUND AND PURPOSE: Chemoradiotherapy (CRT) has led to improved efficacy in treating locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) but has led to almost universal in-field mucositis. Patients treated with the same regimen oft ... Full text Link to item Cite

A pooled analysis of limited-stage small-cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904.

Journal Article J Thorac Oncol · August 2013 INTRODUCTION: Standard therapy for limited-stage small-cell lung cancer (L-SCLC) is concurrent chemotherapy and radiotherapy (RT) followed by prophylactic cranial radiotherapy. Although many consider the standard RT regimen to be 45 Gy in 1.5 Gy twice-dail ... Full text Link to item Cite

Prognostic utility of cell cycle progression score in men with prostate cancer after primary external beam radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2013 PURPOSE: To evaluate the prognostic utility of the cell cycle progression (CCP) score, a RNA signature based on the average expression level of 31 CCP genes, for predicting biochemical recurrence (BCR) in men with prostate cancer treated with external beam ... Full text Link to item Cite

Stereotactic body radiation therapy for treatment of primary and metastatic pulmonary malignancies.

Journal Article Surg Oncol Clin N Am · July 2013 Stereotactic body radiation therapy (SBRT) has become the preferred treatment approach for patients with stage I non-small cell lung cancer who are medically inoperable or refuse surgery. SBRT consists of 3 to 5 radiation treatments delivered over a 10- to ... Full text Link to item Cite

Stereotactic body radiotherapy in patients with stage I non-small-cell lung cancer aged 75 years and older: retrospective results from a multicenter consortium.

Journal Article Clin Lung Cancer · July 2013 BACKGROUND: This study was a retrospective analysis of elderly patients treated with stereotactic body radiotherapy (SBRT) in the setting of a multi-institutional consortium. PATIENTS AND METHODS: Three institutions pooled data on patients aged ≥ 75 years ... Full text Link to item Cite

Stereotactic body radiation therapy for curative treatment of adrenal metastases.

Journal Article Technol Cancer Res Treat · June 2013 The detection of oligometastatic adrenal metastases is increasing and there are limited data supporting the use of curative intent stereotactic body radiation therapy (SBRT) to treat patients with limited metastatic disease with adrenal involvement. Theref ... Full text Link to item Cite

New radiotherapy and chemoradiotherapy approaches for non-small-cell lung cancer.

Journal Article J Clin Oncol · March 10, 2013 Recent advances in systemic cytotoxic and molecularly targeted therapies coupled with technologic strides in radiotherapy have the potential to improve outcomes for patients with non-small-cell lung cancer (NSCLC). Investigations are ongoing to identify op ... Full text Link to item Cite

A phase I dose escalation study of Ad GV.EGR.TNF.11D (TNFerade™ Biologic) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer undergoing reirradiation.

Journal Article Ann Oncol · March 2013 BACKGROUND: AdGV.EGR.TNF.11D (TNFerade™ Biologic) is a replication-deficient adenoviral vector expressing human tumor necrosis factor alpha (TNF-α) under the control of the chemoradiation-inducible EGR-1 promoter. TNF-α has been shown to function as a radi ... Full text Link to item Cite

Prognostic utility of CCP score in men with prostate cancer after primary external beam radiation therapy.

Journal Article J Clin Oncol · February 20, 2013 47 Background: Accurate risk stratification improves decision making in localized prostate cancer. The CCP score, a prognostic RNA signature based on the average expression level of 31 cell cycle progression (CCP) genes, was developed to aid in this task. ... Full text Link to item Cite

Stereotactic radiotherapy for pulmonary metastases.

Journal Article Semin Thorac Cardiovasc Surg · 2013 The most common treatment of pulmonary metastasis for solid tumors employs systemic chemotherapy, hormonal therapy, or biologic agents. Some series have suggested that aggressive surgical resection of pulmonary metastasis may improve patient outcomes in te ... Full text Link to item Cite

Oligometastases/oligo-recurrence of lung cancer

Journal Article Pulmonary Medicine · January 1, 2013 Full text Cite

Feasibility and toxicity of hypofractionated image guided radiation therapy for large volume limited metastatic disease.

Journal Article Pract Radiat Oncol · 2013 PURPOSE: Hypofractionated image guided radiation therapy (HIGRT) is increasingly used for limited metastases. Reported studies have mostly treated small volume tumors. Here, we report the toxicity and oncologic outcomes following treatment of large volume ... Full text Link to item Cite

The utility of FDG-PET for assessing outcomes in oligometastatic cancer patients treated with stereotactic body radiotherapy: a cohort study.

Journal Article Radiat Oncol · December 18, 2012 BACKGROUND: Studies suggest that patients with metastases limited in number and destination organ benefit from metastasis-directed therapy. Stereotactic body radiotherapy (SBRT) is commonly used for metastasis directed therapy in this group. However, the c ... Full text Link to item Cite

Stereotactic body radiotherapy treatment of extracranial metastases.

Journal Article Nat Rev Clin Oncol · November 2012 Radiotherapy is an integral treatment for patients with metastatic cancer, although it is usually reserved for palliation of pain, dyspnoea, oedema, bleeding and neurological symptoms. However, the administration of high-precision radiotherapy, termed ster ... Full text Link to item Cite

Performance and quality of life outcomes for T4 laryngeal cancer patients treated with induction chemotherapy followed by chemoradiotherapy.

Journal Article Oral Oncol · October 2012 Organ-sparing approaches with chemoradiotherapy are often used in the treatment of patients with laryngeal cancer, and the oncologic outcomes of these patients are similar to patients who undergo laryngectomy. However, chemoradiotherapy for laryngeal cance ... Full text Link to item Cite

Reirradiation for recurrent head and neck cancer.

Journal Article Expert Rev Anticancer Ther · September 2012 Recurrence of head and neck cancer in a previously irradiated volume presents a challenging problem and has poor prognosis. A minority of patients are eligible for the preferred therapy, surgical resection. Systemic therapy is offered to patients with unre ... Full text Link to item Cite

Chemoradiation for patients with large-volume laryngeal cancers.

Journal Article Head Neck · August 2012 BACKGROUND: Patients with T4 laryngeal cancers, including those with large-volume (cartilage or tongue-base invasion) lesions, are often excluded from organ-preservation trials due to expectations of inferior outcome in terms of survival and function. We h ... Full text Link to item Cite

SU-E-J-23: Prostate Bed Motion Study Using Surgical Clips Based on Daily CBCT.

Journal Article Med Phys · June 2012 PURPOSE: To study prostate-bed motion after prostatectomy using the surgical clips as a surrogate. METHODS: On the treatment planning CT, surgical clips within the PTV are identified and contoured. They are also identified and contoured in each daily CBCT. ... Full text Link to item Cite

Stereotactic body radiotherapy for multisite extracranial oligometastases: final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease.

Journal Article Cancer · June 1, 2012 BACKGROUND: A subset of patients with metastatic cancer in limited organs may benefit from metastasis-directed therapy. The authors investigated whether patients with limited metastases could be safely treated with metastasis-directed radiotherapy. METHODS ... Full text Link to item Cite

ACR Appropriateness Criteria® ipsilateral radiation for squamous cell carcinoma of the tonsil.

Journal Article Head Neck · May 2012 BACKGROUND: Controversy exists as to the criteria for selecting patients with carcinoma of the tonsil for treatment with ipsilateral radiotherapy (RT). METHODS: The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines ... Full text Link to item Cite

Abstract 3405: MicroRNA expression characterizes oligometastasis(es)

Journal Article Cancer Research · April 15, 2012 AbstractBackground: Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by β5 cumulative metastasis(es), termed oligometastases. I ... Full text Cite

Abstract 1369: Mouse models of clinical oligo- and poly-metastatic progression

Journal Article Cancer Research · April 15, 2012 AbstractWe previously proposed a metastatic state defined by a limited number of metastases, termed oligometastasis(es). These limited metastases may be cured by metastasis-directed treatments in contrast to ... Full text Cite

Hypofractionated image-guided radiation therapy for patients with limited volume metastatic non-small cell lung cancer.

Journal Article J Thorac Oncol · February 2012 INTRODUCTION: Outcomes data treating patients with oligometastatic (≤ 5 metastases) non-small cell lung carcinoma (NSCLC) with hypofractionated image-guided radiotherapy (HIGRT) are limited. METHODS: Consecutive oligometastatic NSCLC patients were reviewed ... Full text Link to item Cite

A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer.

Journal Article Pulm Med · 2012 Metastatic non-small cell lung cancer (NSCLC) carries a dismal prognosis. Clinical evidence suggests the existence of an intermediate, or oligometastatic, state when metastases are limited in number and/or location. In addition, following initial curative ... Full text Link to item Cite

Pathologic response rates following definitive dose image-guided chemoradiotherapy and resection for locally advanced non-small cell lung cancer.

Journal Article Lung Cancer · December 2011 INTRODUCTION: Treatment of technically operable, medically fit locoregionally advanced non-small cell lung cancer (NSCLC) patients is a controversial therapeutic challenge. Our group routinely uses a trimodality approach. Recent advances in radiotherapy al ... Full text Link to item Cite

Pulmonary toxicity in Stage III non-small cell lung cancer patients treated with high-dose (74 Gy) 3-dimensional conformal thoracic radiotherapy and concurrent chemotherapy following induction chemotherapy: a secondary analysis of Cancer and Leukemia Group B (CALGB) trial 30105.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2011 PURPOSE: Cancer and Leukemia Group B (CALGB) 30105 tested two different concurrent chemoradiotherapy platforms with high-dose (74 Gy) three-dimensional conformal radiotherapy (3D-CRT) after two cycles of induction chemotherapy for Stage IIIA/IIIB non-small ... Full text Link to item Cite

Phase II trial of pemetrexed-based induction chemotherapy followed by concomitant chemoradiotherapy in previously irradiated patients with squamous cell carcinoma of the head and neck.

Journal Article Ann Oncol · November 2011 BACKGROUND: Concurrent chemoreirradiation therapy (CRRT) offers a therapeutic option for patients with locoregionally recurrent squamous cell carcinoma of the head and neck (SCCHN). We hypothesized that response to induction chemotherapy (IC) would improve ... Full text Link to item Cite

Prior chemoradiotherapy adversely impacts outcomes of recurrent and second primary head and neck cancer treated with concurrent chemotherapy and reirradiation.

Journal Article Cancer · October 15, 2011 BACKGROUND: It has been shown that concomitant chemotherapy (C) with reirradiation (ReRT) is feasible and effective for select patients with recurrent or second primary head and neck cancer (HNC). To examine potential prognostic factors associated with sur ... Full text Link to item Cite

A randomized phase II study of 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy compared with bevacizumab plus 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy for intermediate-stage and T4N0-1 head and neck cancers.

Journal Article Ann Oncol · October 2011 INTRODUCTION: We conducted a randomized phase II study to evaluate the impact of adding bevacizumab (B) to 5-fluorouracil (5-FU), hydroxyurea (HU), and radiotherapy (FHX) for intermediate-stage and select T4 head and neck squamous cell cancers (HNSCC). PAT ... Full text Link to item Cite

Statin Use and Prostate Cancer Recurrence in Men Treated with Brachytherapy

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Concurrent chemotherapy and intensity-modulated radiotherapy for organ preservation of locoregionally advanced oral cavity cancer.

Journal Article Am J Clin Oncol · August 2011 OBJECTIVES: To report outcomes of oral cavity cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy (chemoIMRT). METHODS: Between 2001 and 2004, 21 patients with oral cavity squamous cell carcinoma underwent definitive c ... Full text Link to item Cite

ACR appropriateness criteria retreatment of recurrent head and neck cancer after prior definitive radiation expert panel on radiation oncology-head and neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2011 Recurrent and second primary head-and-neck squamous cell carcinomas arising within or in close proximity to previously irradiated fields are a common clinical challenge. Whereas surgical salvage therapy is recommended for resectable disease, randomized dat ... Full text Link to item Cite

Adjuvant chemoradiotherapy for locoregionally advanced and high-risk salivary gland malignancies.

Journal Article Head Neck Oncol · July 26, 2011 BACKGROUND: To report the outcomes of patients with locoregionally advanced and high- risk salivary gland malignancies treated with surgery followed by adjuvant chemoradiotherapy. METHODS: From 09/1991 - 06/2007, 24 high-risk salivary gland cancer patients ... Full text Link to item Cite

ACR appropriateness criteria® adjuvant therapy for resected squamous cell carcinoma of the head and neck.

Journal Article Oral Oncol · July 2011 Locoregional recurrence following surgical resection alone for stage III/IV head and neck cancer is common. Adjuvant radiotherapy has been shown to improve post-operative locoregional control when compared to pre-operative radiotherapy for head and neck ca ... Full text Link to item Cite

Predictors of pulmonary toxicity in limited-stage (LS) small cell lung cancer (SCLC) patients treated with concurrent chemotherapy (CTX) and high-dose (70 Gy) daily radiotherapy (RT): A pooled analysis of three CALGB studies.

Journal Article J Clin Oncol · May 20, 2011 7078 Background: Predictors of post CTX-RT pulmonary toxicity in LS-SCLC patients are not well defined. Current guidelines are derived from NSCLC regimens, not accounting for the unique biology of SCLC. We analyzed patients on 3 consecutive CALGB LS-SCLC t ... Link to item Cite

A randomized phase II trial of cetuximab-based induction chemotherapy followed by concurrent cetuximab, 5-FU, hydroxyurea, and hyperfractionated radiation (CetuxFHX), or cetuximab, cisplatin, and accelerated radiation with concomitant boost (CetuxPX) in patients with locoregionally advanced head and neck cancer (HNC).

Journal Article J Clin Oncol · May 20, 2011 5519 Background: Cetuximab is commonly used in combination with either chemotherapy or radiation in the treatment of HNC, although the optimal way to integrate cetuximab with concurrent chemoradiation (CRT) remains unclear. We explored the addition of cetu ... Link to item Cite

SU‐E‐T‐266: Propagation of Human Error within a Radiation Oncology Department

Conference Medical Physics · January 1, 2011 Purpose: To study propagation of human error in EBRT in a small radonc department. Methods:While reporting of medical events is mandatory, reporting of other human errors needs encouragement. A mechanism of voluntary reporting 1 was adopted. Specifically, ... Full text Cite

MicroRNA expression characterizes oligometastasis(es).

Journal Article PLoS One · 2011 BACKGROUND: Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤ 5 cumulative metastasis(es), termed oligometastases. In contrast to widespread polymetastases, oligometastatic ... Full text Link to item Cite

Factors associated with long-term speech and swallowing outcomes after chemoradiotherapy for locoregionally advanced head and neck cancer.

Journal Article Arch Otolaryngol Head Neck Surg · December 2010 OBJECTIVE: to identify factors that influence patient-centered measures of speech and swallowing function after successful use of chemoradiotherapy to treat cancers of the head and neck. DESIGN: patients previously enrolled in a phase 2 trial using inducti ... Full text Link to item Cite

Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue.

Journal Article Head Neck · November 2010 BACKGROUND: Our aim was to report the outcomes of base of tongue cancers treated with chemoradiotherapy. METHODS: Between 1990 and 2004, 127 patients with stage III or IV base of tongue cancer were treated with chemoradiotherapy on protocol. Indications in ... Full text Link to item Cite

Adjuvant chemotherapy prior to postoperative concurrent chemoradiotherapy for locoregionally advanced head and neck cancer.

Journal Article Radiother Oncol · November 2010 BACKGROUND AND PURPOSE: Induction chemotherapy prior to definitive concurrent chemoradiotherapy (CCRT) is a promising treatment option for unresectable head and neck cancer (HNC). In the postoperative setting, the efficacy of such an approach with adjuvant ... Full text Link to item Cite

Hypofractionated Image Guided Radiotherapy for Large Volume Oligometastases

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Hypofractionated Image-guided Radiation Therapy in the Treatment of Oligometastatic Renal Cell Carcinoma

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer.

Journal Article J Clin Oncol · July 10, 2010 PURPOSE: Assess efficacy and toxicity of gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, added to, and in maintenance after, concurrent chemoradiotherapy (CCRT) in locally advanced head and neck cancer (LA-HNC) and correlate outcomes with ... Full text Link to item Cite

Chemoreirradiation for recurrent salivary gland malignancies.

Journal Article Radiother Oncol · June 2010 BACKGROUND AND PURPOSE: To report our experience in treating recurrent salivary gland malignancies using concurrent chemotherapy and reirradiation. MATERIALS AND METHODS: Between 1986 and 2007, 14 patients with locoregionally recurrent salivary gland cance ... Full text Link to item Cite

Predictors of competing mortality in advanced head and neck cancer.

Journal Article J Clin Oncol · January 1, 2010 PURPOSE Death from noncancer causes (competing mortality) is an important event in head and neck cancer, but studies identifying predictors of this event are lacking. We sought to identify predictors of competing mortality and develop a risk stratification ... Full text Link to item Cite

ACR Appropriateness Criteria: local-regional therapy for resectable oropharyngeal squamous cell carcinomas.

Journal Article Curr Probl Cancer · 2010 The optimal management of resectable oropharyngeal squamous cell carcinomas is controversial with many treatment options, both surgical and nonsurgical approaches, supported by published experiences with no randomized trials comparing commonly accepted tre ... Full text Link to item Cite

Chemoradiation for patients with advanced oral cavity cancer.

Journal Article Laryngoscope · January 2010 OBJECTIVES/HYPOTHESIS: Patients with advanced oral cavity cancer (OCC) typically have not been enrolled in clinical trials utilizing contemporary multimodality strategies. There exist dogmatic expectations of inferior outcome in OCC patients secondary to i ... Full text Link to item Cite

Neck response to chemoradiotherapy: complete radiographic response correlates with pathologic complete response in locoregionally advanced head and neck cancer.

Journal Article Arch Otolaryngol Head Neck Surg · November 2009 OBJECTIVE: The role of neck dissection following chemoradiotherapy (CRT) for locoregionally advanced head and neck cancer is an area of active debate. Patients who have a complete radiographic response may not need dissection, and the extent of neck dissec ... Full text Link to item Cite

A multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy.

Journal Article Radiother Oncol · November 2009 Using previous dosimetric analysis methods, we identified the volume of bowel receiving 30 Gy (V(30)) correlated with acute gastrointestinal (GI) toxicity in anal cancer patients treated with intensity-modulated radiation therapy and concurrent chemotherap ... Full text Link to item Cite

Clinical practice guidance for radiotherapy planning after induction chemotherapy in locoregionally advanced head-and-neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2009 PURPOSE: The use of induction chemotherapy (IC) for locoregionally advanced head-and-neck cancer is increasing. The response to IC often causes significant alterations in tumor volume and location and shifts in normal anatomy. Proper determination of the r ... Full text Link to item Cite

Single Segment Non-coplanar Beam Optimization for Gated Lung SBRT Planning and Delivery

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Correlation of body mass index with toxicity and survival in locoregionally advanced head and neck cancer patients treated with induction chemotherapy and concurrent chemoradiotherapy.

Journal Article J Clin Oncol · May 20, 2009 6074 Background: Concurrent chemoradiotherapy (CRT) offers high functional organ preservation rates for locoregionally advanced head and neck cancer (LRAHNC) patients, but is associated with significant acute and chronic speech and swallowing toxicity. Rec ... Link to item Cite

Advances in radiotherapy for tumors involving the mediastinum.

Journal Article Thorac Surg Clin · February 2009 RT is an integral component of treatment in many tumors of the mediastinum. In recent years, there have been advances in RT planning and delivery, which have allowed more effective radiation delivery while sparing normal tissues. New technologies and radia ... Full text Link to item Cite

Calculation and prediction of the effect of respiratory motion on whole breast radiation therapy dose distributions.

Journal Article Med Dosim · 2009 The standard treatment technique used for whole-breast irradiation can result in undesirable dose distributions in the treatment site, leading to skin reaction/fibrosis and pulmonary and cardiac toxicities. Hence, the technique has evolved from conventiona ... Full text Link to item Cite

Induction chemotherapy and concurrent chemoradiotherapy for locoregionally advanced head and neck cancer: a multi-institutional phase II trial investigating three radiotherapy dose levels.

Journal Article Ann Oncol · October 2008 BACKGROUND: We hypothesized induction chemotherapy (IndCT) would improve distant control (DC) without compromising locoregional control (LRC) for locoregionally advanced head and neck cancer patients. Additionally, we systematically lowered radiotherapy (R ... Full text Link to item Cite

Characteristics associated with swallowing changes after concurrent chemotherapy and radiotherapy in patients with head and neck cancer.

Journal Article Arch Otolaryngol Head Neck Surg · October 2008 OBJECTIVE: To define factors that acutely influenced swallowing function prior to and during concurrent chemotherapy and radiotherapy. DESIGN: A summary score from 1 to 7 (the swallowing performance status scale [SPS]) of oral and pharyngeal impairment, as ... Full text Link to item Cite

Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma.

Journal Article Ann Oncol · September 2008 BACKGROUND: Randomized trials established chemoradiotherapy as standard treatment for advanced laryngeal cancer. Patients with large-volume T4 disease (LVT4) were excluded from these trials. The purpose of this study was to report T4 laryngeal cancer patie ... Full text Link to item Cite

A rationale for the targeted treatment of oligometastases with radiotherapy.

Journal Article J Surg Oncol · September 1, 2008 An oligometastatic state has been proposed wherein patients with metastases limited in number and location may benefit from local therapy directed at all known sites of metastases. We describe here the clinical and biological basis for the oligometastatic ... Full text Link to item Cite

Factors Associated with Non-cancer Mortality in Advanced Head and Neck Cancer: A Competing Risks Analysis

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Monte Carlo Evaluation of Stereotactic Body Radiotherapy (SBRT) Treatment Planning for Lung Tumors

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease.

Journal Article Clin Cancer Res · August 15, 2008 PURPOSE: Previous investigations have suggested that a subset of patients with metastatic cancer in a limited number of organs may benefit from local treatment. We investigated whether cancer patients with limited sites of metastatic disease (oligometastas ... Full text Link to item Cite

Concurrent chemotherapy and re-irradiation for locoregionally recurrent head and neck cancer.

Journal Article Semin Oncol · June 2008 Recurrent and second primary tumors arising within a previously radiated head and neck volume represent a difficult clinical scenario to manage. For patients who have resectable disease, surgery is the standard treatment. Chemotherapy is the standard for p ... Full text Link to item Cite

Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2008 PURPOSE: To test the hypothesis that the volume of pelvic bone marrow (PBM) receiving 10 and 20 Gy or more (PBM-V(10) and PBM-V(20)) is associated with acute hematologic toxicity (HT) in anal cancer patients treated with concurrent chemoradiotherapy. METHO ... Full text Link to item Cite

In reply

Journal Article Journal of Clinical Oncology · February 1, 2008 Full text Cite

Does Cetuximab Improve Control of Advanced Head and Neck Cancer? A Second Look at the Randomized Trial by Bonner, et al.

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience.

Journal Article J Clin Oncol · October 10, 2007 PURPOSE: To report a multicenter experience treating anal canal cancer patients with concurrent chemotherapy and intensity-modulated radiation therapy (IMRT). PATIENTS AND METHODS: From October 2000 to June 2006, 53 patients were treated with concurrent ch ... Full text Link to item Cite

Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers.

Journal Article Am J Clin Oncol · June 2007 OBJECTIVES: For locally advanced but technically operable nonsmall cell lung cancer (NSCLC), neoadjuvant chemoradiotherapy is frequently used. Ideal radiotherapy dose in this context is unclear. MATERIALS AND METHODS: Twenty-six NSCLC patients with N2 dise ... Full text Link to item Cite

The chemoradiation paradigm in head and neck cancer.

Journal Article Nat Clin Pract Oncol · March 2007 In this article, we use the example of head and neck cancer to show how concurrent chemoradiotherapy is used to treat a cancer where locoregional control is central for treatment success. The advent of concurrent chemoradiation has significantly contribute ... Full text Link to item Cite

The concurrent chemoradiation paradigm--general principles.

Journal Article Nat Clin Pract Oncol · February 2007 During the past 20 years, the advent of neoadjuvant, primary, and adjuvant concurrent chemoradiotherapy has improved cancer care dramatically. Significant contributions have been made by technological improvements in radiotherapy, as well as by the introdu ... Full text Link to item Cite

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.

Journal Article J Exp Med · January 22, 2007 Targeting cancer cells, as well as the nonmalignant stromal cells cross-presenting the tumor antigen (Ag), can lead to the complete destruction of well-established solid tumors by adoptively transferred Ag-specific cytotoxic T lymphocytes (CTLs). If, howev ... Full text Link to item Cite

SU‐FF‐T‐11: A Dosimetric Study of the Effect of Respiratory Motion On Whole Breast Radiation Therapy

Journal Article Medical Physics · January 1, 2007 Purpose: Study the effect of respiratory motion on whole breast radiotherapy for three treatment planning techniques: conventional wedged technique (CWT), segment IMRT (SIMRT) and beamlet IMRT (BIMRT). Investigate the relationship between the dosimetric co ... Full text Cite

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Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

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Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

2114

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

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Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

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Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

2564

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

Preliminary outcome and toxicity report of extended-field, intensity-modulated radiation therapy for gynecologic malignancies.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2006 PURPOSE: The aim of this article is to report a preliminary analysis of our initial clinical experience with extended-field intensity-modulated radiotherapy for gynecologic malignancies. METHODS AND MATERIALS: Between November 2002 and May 2005, 13 women w ... Full text Link to item Cite

Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2006 PURPOSE: To define favorable pretreatment characteristics for overall survival (OS), progression-free survival (PFS), locoregional control, and freedom from distant metastasis for patients with recurrent and second primary head-and-neck cancer treated with ... Full text Link to item Cite

Twice-daily reirradiation for recurrent and second primary head-and-neck cancer with gemcitabine, paclitaxel, and 5-fluorouracil chemotherapy.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2005 PURPOSE: We previously demonstrated the efficacy of concurrent gemcitabine, paclitaxel, and 5-fluorouracil in conjunction with twice-daily (1.5-Gy) radiotherapy delivered on alternating weeks (TFGX(2)) in locally advanced head-and-neck cancer. Here, we rep ... Full text Link to item Cite

Does the number of lymph nodes examined in patients with lymph node-negative breast carcinoma have prognostic significance?

Journal Article Cancer · February 15, 2005 BACKGROUND: There are conflicting data on the prognostic significance of the number of lymph nodes examined in patients with lymph node-negative breast carcinoma. Therefore, the authors analyzed the impact of the number of tumor-free axillary lymph nodes o ... Full text Link to item Cite

Phase I study of concomitant chemoradiotherapy with irinotecan, 5-FU, and hydroxyurea for patients with advanced and/or recurrent head and neck cancer.

Journal Article Cancer J · 2005 PURPOSE: We sought to investigate CPT-11 as a promising agent to our established regimen of 5-fluorouracil (5-FU), hydroxyurea, and hyperfractionated radiation therapy. A phase I study was conducted to determine the maximum tolerated dose and dose-limiting ... Full text Link to item Cite

Phase I study of concomitant chemoradiotherapy with irinotecan, 5-FU, and hydroxyurea for patients with advanced and/or recurrent head and neck cancer: Toxicity and outcome results.

Journal Article J Clin Oncol · July 15, 2004 5561 Background: At University of Chicago, concomitant chemoRT for advanced and recurrent head and neck cancer has been studied for 2 decades. We investigated the addition of CPT-11 as a promising new agent to our established regimen of 5-FU, hydroxyurea ( ... Link to item Cite

Intensity-modulated radiation therapy in gynecologic malignancies.

Journal Article Curr Treat Options Oncol · April 2004 Radiation therapy occupies an important role in the treatment of gynecologic malignancies. Unfortunately, traditional approaches result in the irradiation of large volumes of normal tissues exposing patients to many toxicities and precluding dose escalatio ... Full text Link to item Cite

Evaluation of patients after extraperitoneal lymph node dissection and subsequent radiotherapy for cervical cancer.

Journal Article Gynecol Oncol · February 2002 OBJECTIVE: The presence of nodal metastases is the most important prognostic factor in cervical cancer. To adjust our therapy based on the true extent of the patient's disease, we performed an extraperitoneal lymph node dissection (EPLND) in all patients w ... Full text Link to item Cite

Phase I Study of Concomitant Chemoradiotherapy with Irinotecan, 5-FU, and Hydroxyurea fot Patients with Advanced and/or Recurrent Head and Neck Cancer

Journal Article Cancer Journal · December 1, 1998 PURPOSE We sought to investigate CPT-11 as a promising agent to our established regimen of 5-fluorouracil (5-FU), hydroxyurea, and hyperfractionated radiation therapy. A phase I study was conducted to determine the maximum tolerated dose and dose-limiting ... Cite

The morphology of the femur in developmental dysplasia of the hip.

Journal Article J Bone Joint Surg Br · July 1998 We studied the morphometry of 35 femora from 31 female patients with developmental dysplasia of the hip (DDH) and another 15 from 15 age- and sex-matched control patients using CT and three-dimensional computer reconstruction models. According to the class ... Full text Link to item Cite

TEM studies of dislocations in deformed melt-textured YBa2Cu30x superconductors

Journal Article Journal of Materials Research · January 1, 1993 TEM studies have been conducted on melt-textured YBa2Cu3Ox, samples that were uniaxially and isostatically deformed at high temperatures and compared with those of undeformed samples. Dislocation pile-ups along [100] and [010] are found to be the common fe ... Full text Cite

Is a single isocenter sufficient for volumetric modulated arc therapy radiosurgery when multiple itracranial metastases are spatially dispersed?

Journal Article Med Dosim Previous work demonstrated improved dosimetry of single isocenter volumetric modulated arc therapy (VMAT) of multiple intracranial targets when they are located ≤ 4cm from isocenter because of narrower multileaf collimators (MLCs). In follow-up, we sought ... Full text Link to item Cite

Hippocampal dose from stereotactic radiosurgery for 4 to 10 brain metastases: Risk factors, feasibility of dose reduction via re-optimization, and patient outcomes.

Conference Med Dosim This study aimed to report hippocampal dose from single-fraction stereotactic radiosurgery (SRS) for 4 to 10 brain metastases and determine feasibility of hippocampal-sparing SRS. Patients with 4 to 10 brain metastases receiving single-isocenter, multi-tar ... Full text Link to item Cite