Scholars@Duke
Katherine Zhou

Selected Publications

Comprehensive Genomic Profiling in Non-Myeloid Hematologic Malignancies Identifies Variants That Can Alter Clinical Practice.

Journal Article Hematol Rep · September 30, 2024 BACKGROUND: Comprehensive genomic profiling (CGP) is frequently adopted to direct the clinical care of myeloid neoplasms and solid tumors, but its utility in the care of lymphoid and histiocytic cancers is less well defined. METHODS: In this study, we aime ... Full text Link to item Cite

Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis.

Journal Article Science · June 21, 2024 The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, which limits the development of effective therapies. In this work, we show that BCCs in mice can invade the LM ... Full text Link to item Cite

Management of Microsatellite Instability High (MSI-H) Gastroesophageal Adenocarcinoma.

Journal Article J Gastrointest Cancer · June 2024 BACKGROUND: Gastroesophageal cancer is a major cause of cancer-related mortality worldwide. Treatment of both early stage and advanced disease remains highly reliant on cytotoxic chemotherapy. About 4-24% of gastroesophageal cancers are microsatellite inst ... Full text Link to item Cite

Brief Report: Real-World Efficacy and Safety of Sotorasib in U.S. Veterans with KRAS G12C-Mutated NSCLC.

Journal Article JTO Clin Res Rep · May 2024 INTRODUCTION: The KRAS G12C inhibitor sotorasib was approved for treating advanced NSCLC in the second line or later on the basis of the CodeBreaK100 trial. Nevertheless, data on the real-world efficacy and safety of sotorasib, and to its optimal dose, rem ... Full text Link to item Cite

2'-O-methylation (Nm) in RNA: progress, challenges, and future directions.

Journal Article RNA · April 16, 2024 RNA 2'-O-methylation (Nm) is highly abundant in noncoding RNAs including ribosomal RNA (rRNA), transfer RNA (tRNA), and small nuclear RNA (snRNA), and occurs in the 5' cap of virtually all messenger RNAs (mRNAs) in higher eukaryotes. More recently, Nm has ... Full text Link to item Cite

Surprise diagnosis of acquired von Willebrand syndrome in a patient previously thought to have type III von Willebrand disease: evaluation and periprocedural management.

Journal Article BMJ Case Rep · December 6, 2023 Acquired von Willebrand syndrome (AVWS) is a rare disorder that is characterised by an acquired deficiency of von Willebrand factor. AVWS was suspected in a patient with type III von Willebrand disease (VWD) who did not respond to factor replacement therap ... Full text Link to item Cite

Reply to M.S. Brose et al.

Journal Article JCO Precis Oncol · September 2023 Full text Link to item Cite

Utility of Tumor Mutational Burden as a Biomarker for Response to Immune Checkpoint Inhibition in the VA Population.

Journal Article JCO Precis Oncol · September 2023 PURPOSE: Immune checkpoint inhibitors (ICIs) are used for an increasing number of indications across various tumor types, as well as several tumor-agnostic indications in patients with advanced cancer. Although many patients benefit from ICI therapy, other ... Full text Link to item Cite

Dasatinib-associated follicular lymphoma in a patient with B-cell acute lymphoblastic leukaemia.

Journal Article BMJ Case Rep · May 17, 2023 The tyrosine kinase inhibitor dasatinib is approved for the treatment of chronic myeloid leukaemia and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia (ALL). Patients on dasatinib can rarely develop a form of benign reversible reactive ... Full text Link to item Cite

Real-world Experience With Neurotrophic Tyrosine Receptor Kinase Fusion-positive Tumors and Tropomyosin Receptor Kinase Inhibitors in Veterans.

Journal Article JCO Precis Oncol · March 2023 PURPOSE: Neurotrophic tyrosine receptor kinase 1-3 (NTRK1-3) gene fusions are found in a broad range of tumor types. Clinical trials demonstrated high response rates to tropomyosin receptor kinase (TRK) inhibitors in NTRK fusion-positive cancers, but few r ... Full text Link to item Cite

Spatial and Temporal Heterogeneity of PD-L1 Expression and Tumor Mutational Burden in Gastroesophageal Adenocarcinoma at Baseline Diagnosis and after Chemotherapy.

Journal Article Clinical cancer research : an official journal of the American Association for Cancer Research · December 2020 PurposeIntrapatient heterogeneity of programmed death ligand 1 (PD-L1) expression and tumor mutational burden (TMB) in gastroesophageal adenocarcinoma (GEA) could influence their roles as predictive biomarkers for response to immune checkpoint inh ... Full text Cite

Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG.

Journal Article Molecular cell · October 2019 N6-methyladenosine (m6A) modification occurs co-transcriptionally and impacts pre-mRNA processing; however, the mechanism of co-transcriptional m6A-dependent alternative splicing regulation is still poorly understood. Heter ... Full text Cite

Sensitive and quantitative probing of pseudouridine modification in mRNA and long noncoding RNA.

Journal Article RNA (New York, N.Y.) · September 2019 Pseudouridine (Ψ) is the most abundant RNA modification in cellular RNA present in tRNA/rRNA/snRNA and also in mRNA and long noncoding RNA (lncRNA). Elucidation of Ψ function in mRNA/lncRNA requires mapping and quantitative assessment of its modification f ... Full text Cite

An additional class of m6A readers.

Journal Article Nature cell biology · March 2018 Full text Cite

Pseudouridines have context-dependent mutation and stop rates in high-throughput sequencing.

Journal Article RNA biology · January 2018 The abundant RNA modification pseudouridine (Ψ) has been mapped transcriptome-wide by chemically modifying pseudouridines with carbodiimide and detecting the resulting reverse transcription stops in high-throughput sequencing. However, these methods have l ... Full text Cite

Identification of N6-methyladenosine reader proteins.

Journal Article Methods (San Diego, Calif.) · August 2017 The reversible N6-methyladenosine (m6A) modification of eukaryotic messenger RNAs (mRNAs) is a widespread regulatory mechanism that impacts every step in the mRNA life cycle. The effect of m6A on mRNA fate depends on the bi ... Full text Cite

N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.

Journal Article Nucleic Acids Res · June 2, 2017 N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA (mRNA), and affects almost every stage of the mRNA life cycle. The YTH-domain proteins can specifically recognize m6A modification to control mRNA maturation, t ... Full text Link to item Cite

Structures of the m(6)A Methyltransferase Complex: Two Subunits with Distinct but Coordinated Roles.

Journal Article Molecular cell · July 2016 In this issue of Molecular Cell, Wang et al. (2016a) report crystal structures of the core of the METTL3/METTL14 m(6)A methyltransferase complex and propose how the two subunits interact and cooperate to bind and methylate RNA. ... Full text Cite

N(6)-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding.

Journal Article J Mol Biol · February 27, 2016 N(6)-Methyladenosine (m(6)A) is a reversible and abundant internal modification of messenger RNA (mRNA) and long noncoding RNA (lncRNA) with roles in RNA processing, transport, and stability. Although m(6)A does not preclude Watson-Crick base pairing, the ... Full text Link to item Cite

Predicted group II intron lineages E and F comprise catalytically active ribozymes.

Journal Article RNA (New York, N.Y.) · September 2013 Group II introns are self-splicing, retrotransposable ribozymes that contribute to gene expression and evolution in most organisms. The ongoing identification of new group II introns and recent bioinformatic analyses have suggested that there are novel lin ... Full text Cite

Longevity and stress in Caenorhabditis elegans.

Journal Article Aging · August 2011 It has long been understood that many of the same manipulations that increase longevity in Caenorhabditis elegans also increase resistance to various acute stressors, and vice-versa; moreover these findings hold in more complex organisms as well. Neverthel ... Full text Cite

MicroRNAs both promote and antagonize longevity in C. elegans.

Journal Article Current biology : CB · December 2010 Backgroundaging is under genetic control in C. elegans, but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implicated in ... Full text Cite

Enhancement of insulin action by bis(acetylacetonato)oxovanadium(IV) occurs through uncompetitive inhibition of protein tyrosine phosphatase-1B

Conference ACS Symposium Series · January 1, 2007 We have examined the influence of bis(acetylacetonato)oxovanadium(IV) [VO(acac)2] on the catalytic activity of protein tyrosine phosphatase-IB (PTPlB). In the presence of p-nitrophenylphosphate as the substrate, VO(acac)2 exhibited mixed inhibition. Howeve ... Full text Cite