Dasatinib-associated follicular lymphoma in a patient with B-cell acute lymphoblastic leukaemia.
Publication
, Journal Article
Zhou, KI; Lin, C; Neff, JL; Galal, A
Published in: BMJ Case Rep
May 17, 2023
The tyrosine kinase inhibitor dasatinib is approved for the treatment of chronic myeloid leukaemia and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia (ALL). Patients on dasatinib can rarely develop a form of benign reversible reactive lymphadenopathy termed follicular lymphoid hyperplasia (FLH). Here, we describe a patient with Ph+ ALL who developed follicular lymphoma (FL) after prolonged treatment with dasatinib and who had complete remission of FL after discontinuation of dasatinib. This case suggests that dasatinib-associated FLH could be a premalignant condition that can transform into FL. Moreover, withdrawal of dasatinib may be sufficient for remission of dasatinib-associated FL.
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Published In
BMJ Case Rep
DOI
EISSN
1757-790X
Publication Date
May 17, 2023
Volume
16
Issue
5
Location
England
Related Subject Headings
- Protein Kinase Inhibitors
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Philadelphia Chromosome
- Lymphoma, Follicular
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Humans
- Dasatinib
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
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MLA
NLM
Zhou, K. I., Lin, C., Neff, J. L., & Galal, A. (2023). Dasatinib-associated follicular lymphoma in a patient with B-cell acute lymphoblastic leukaemia. BMJ Case Rep, 16(5). https://doi.org/10.1136/bcr-2022-252739
Zhou, Katherine Ismei, Chenyu Lin, Jadee Lee Neff, and Ahmed Galal. “Dasatinib-associated follicular lymphoma in a patient with B-cell acute lymphoblastic leukaemia.” BMJ Case Rep 16, no. 5 (May 17, 2023). https://doi.org/10.1136/bcr-2022-252739.
Zhou KI, Lin C, Neff JL, Galal A. Dasatinib-associated follicular lymphoma in a patient with B-cell acute lymphoblastic leukaemia. BMJ Case Rep. 2023 May 17;16(5).
Zhou, Katherine Ismei, et al. “Dasatinib-associated follicular lymphoma in a patient with B-cell acute lymphoblastic leukaemia.” BMJ Case Rep, vol. 16, no. 5, May 2023. Pubmed, doi:10.1136/bcr-2022-252739.
Zhou KI, Lin C, Neff JL, Galal A. Dasatinib-associated follicular lymphoma in a patient with B-cell acute lymphoblastic leukaemia. BMJ Case Rep. 2023 May 17;16(5).
Published In
BMJ Case Rep
DOI
EISSN
1757-790X
Publication Date
May 17, 2023
Volume
16
Issue
5
Location
England
Related Subject Headings
- Protein Kinase Inhibitors
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Philadelphia Chromosome
- Lymphoma, Follicular
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Humans
- Dasatinib
- 42 Health sciences
- 32 Biomedical and clinical sciences