Scholars@Duke
Eugene C. Kovalik

Eugene C. Kovalik

Professor of Medicine
Medicine, Nephrology
koval001@mc.duke.edu
Duke Box 2747, Durham, NC 27705
2424 Erin Road, Suite 605, Durham, NC 27705

Selected Publications

Methods of Hemodialysis Anticoagulation

Chapter · January 1, 2022 Exposure of blood during the hemodialysis procedure to the extracorporeal circuit increases the risk of clotting in the circuit and inefficient treatment. We review current anticoagulation protocols used most in outpatient and inpatient hemodialysis units. ... Full text Cite

The association between Self-Reported Medication Adherence scores and systolic blood pressure control: a SPRINT baseline data study.

Journal Article J Am Soc Hypertens · November 2016 We examined baseline data from the Systolic Blood Pressure Intervention Trial (SPRINT) to investigate whether medication adherence, measured by the 8-item Morisky Medication Adherence Scale (MMAS-8), was associated with systolic blood pressure (SBP) and wh ... Full text Link to item Cite

Methods of hemodialysis anticoagulation

Journal Article · December 1, 2008 Full text Cite

Alternative methods of anticoagulation for dialysis-dependent patients with heparin-induced thrombocytopenia.

Journal Article Semin Dial · 2003 Dialysis patients who are continually exposed to heparin are at risk for heparin-induced thrombocytopenia (HIT). Heparin-induced antibodies have been reported to occur in 0-12% of hemodialysis (HD) patients. The diagnosis or suspicion of HIT in this patien ... Full text Link to item Cite

Treatment approaches for infected hemodialysis vascular catheters.

Journal Article Curr Opin Nephrol Hypertens · November 2002 PURPOSE OF REVIEW: The focus of the review is to delineate protocols for catheter removal, catheter replacement and duration of therapy when a catheter-related infection occurs, and to demonstrate possible means of preventing such infections. RECENT FINDIN ... Full text Link to item Cite

Normalization of hematocrit in hemodialysis patients does not affect silent ischemia.

Journal Article Ren Fail · March 2000 UNLABELLED: Transient ST-segment depression measured on ambulatory ECG monitors has been described as representing silent ischemia. Patients who demonstrate silent ischemia have been reported to show increased mortality compared to patients without silent ... Full text Link to item Cite

Normalization of hematocrit in hemodialysis patients with cardiac disease does not increase blood pressure.

Journal Article Ren Fail · 2000 UNLABELLED: Since the earliest reports of the use of Epoetin alfa in hemodialysis patients, it has been described that Epoetin alfa may exacerbate preexisting hypertension or induce hypertension in End Stage Renal Disease (ESRD) patients not previously hyp ... Full text Link to item Cite

Role of urine and serum protein electrophoresis in evaluation of nephrotic-range proteinuria.

Journal Article Am J Kidney Dis · July 1999 The usefulness of routine serum protein electrophoresis (SPEP) and urine protein electrophoresis (UPEP) screening in the evaluation of proteinuria is not known. The data on the clinical utility of these tests in 165 male patients with proteinuria greater t ... Full text Link to item Cite

Implementation of the Dialysis Outcomes Quality Initiative Vascular Access Guidelines.

Journal Article Adv Ren Replace Ther · January 1999 To better care for patients with chronic renal failure and end-stage renal disease, the National Kidney Foundation has published a set of Clinical Guidelines, the Dialysis Outcomes Quality Initiative, based on current available evidence and, where such evi ... Full text Link to item Cite

Can venous stenosis be prevented?

Journal Article Seminars in Dialysis · January 1, 1999 Full text Cite

Survival in renal vascular disease.

Journal Article J Am Soc Nephrol · February 1998 Renal artery stenosis (RAS) is a relatively uncommon but important potentially reversible cause of renal failure. Little is known about the natural history of ischemic renal disease secondary to RAS. In previous reports, these researchers examined the inci ... Full text Link to item Cite

A clustering of epidural abscesses in chronic hemodialysis patients: risks of salvaging access catheters in cases of infection.

Journal Article J Am Soc Nephrol · October 1996 The objective of this study was to investigate factors that might increase the risk of epidural abscesses in hemodialysis patients. The charts of all hemodialysis patients presenting with an epidural abscess over a period of 5 yr at Duke University Hospita ... Full text Link to item Cite

No change in complication rate using spring-loaded gun compared to traditional percutaneous renal allograft biopsy techniques.

Journal Article Clin Nephrol · June 1996 The previous methods to biopsy renal allografts at our institution involved the use of the Franklin-Silverman or Tru-Cut needles. Unfortunately they had a significant rate of post biopsy bleeding secondary to deep penetration when excess force was used to ... Link to item Cite

NORMALIZATION OF HEMATOCRIT DOES NOT AFFECT LIPOPROTEIN PROFILES IN HEMODIALYSIS-PATIENTS

Journal Article JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY · September 1, 1995 Link to item Cite

Percutaneous renal biopsy of ventilated intensive care unit patients.

Journal Article Clin Nephrol · May 1995 The etiology of acute renal failure in ventilated intensive care unit patients can be determined non-invasively in more than 80% of cases. When a pulmonary renal syndrome is suspected however it is important to obtain histological confirmation of the diagn ... Link to item Cite

The renal manifestations and outcome of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in adults.

Journal Article Nephrol Dial Transplant · 1995 Thrombotic thrombocytopenic purpura/Hemolytic uremic syndrome (TTP/HUS) is generally regarded to be a rare disease. The present study was undertaken to identify presenting features, prognostic variables, pathological features and outcome associated with TT ... Link to item Cite

Strategies for preventing diabetic nephropathy.

Journal Article N C Med J · August 1994 Link to item Cite

Correction of central venous stenoses: use of angioplasty and vascular Wallstents.

Journal Article Kidney Int · April 1994 Central venous stenoses are a frequent complication in hemodialysis patients. These lesions lead to fistula thromboses, arm swelling, and limit future vascular access. Stenoses are characterized by excellent initial response to transluminal angioplasty but ... Full text Link to item Cite

LOSS OF TRADITIONAL HEMODIALYSIS ACCESS SITES: I

Journal Article Seminars in Dialysis · January 1, 1993 Full text Cite

Bulk laxative causing esophageal obstruction.

Journal Article N C Med J · September 1989 Link to item Cite

Double antibody radioimmunoassay for monitoring metastatic breast cancer.

Journal Article Br J Cancer · September 1988 We previously reported the production of a panel of murine monoclonal antibodies which recognize glycoproteins abnormally expressed in human breast tumours. Using two of these antibodies, a double antibody radioimmunoassay was designed to quantify levels o ... Full text Link to item Cite

Monoclonal antibodies to antigens abnormally expressed in breast cancer.

Journal Article J Histochem Cytochem · February 1987 We report the production, screening, and characterization of ten murine monoclonal antibodies directed at antigens that are expressed abnormally in human breast tumors. Immunoperoxidase staining of frozen and fixed tissues shows the antigens to be present ... Full text Link to item Cite