Kristin M. Schroeder

Journal Article J Health Popul Nutr · June 5, 2025 BACKGROUND: Childhood cancer is a growing public health concern in low- and middle-income countries (LMICs), where over two-thirds of global pediatric cancer cases occur. Despite advances in diagnosis and treatment, malnutrition remains a major barrier to ... Full text Link to item Cite

Rituximab for children with EBV-positive Burkitt lymphoma in East Africa.

Journal Article Blood Adv · May 27, 2025 The addition of rituximab to the chemotherapy backbone was shown to significantly improve outcomes of children with aggressive high-grade lymphomas in high-income countries. However, data on its safety and efficacy in children with Epstein-Barr virus (EBV) ... Full text Link to item Cite

Childhood Cancer Survivorship Care in Limited Resource Settings: A Narrative Review and Strategies to Promote Global Health Equity.

Journal Article JCO Glob Oncol · February 2025 The WHO Global Initiative for Childhood Cancer, prompted by the marked inequity of survival across the globe, aims to increase survival rates in low- and middle-income countries to 60% by 2030. In tandem with this effort, implementing survivorship-focused ... Full text Link to item Cite

Targeted Next-Generation Sequencing of Cell-Free DNA to Detect MYC-Immunoglobulin Translocation and Epstein-Barr Virus DNA in Plasma of Burkitt Lymphoma Patients in East Africa.

Journal Article JCO Glob Oncol · January 2025 PURPOSE: Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) affects children in sub-Saharan Africa, but diagnosis via tissue biopsy is challenging. We explored a liquid biopsy approach using targeted next-generation sequencing to detect the MYC-immuno ... Full text Link to item Cite

Pharmacogenomics of Chemotherapies for Childhood Cancers in Africa: A Scoping Review.

Journal Article Pharmgenomics Pers Med · 2025 BACKGROUND: Pharmacogenomics holds significant promise in improving the efficacy and safety of chemotherapy for childhood cancers. However, the field remains underexplored in Africa, where high genetic diversity and substantial disease burdens, including c ... Full text Link to item Cite

Prescription patterns of supportive care medications among children receiving chemotherapy treatments at a major referral hospital in Tanzania: where are we in managing chemotherapy-induced toxicities?

Journal Article Front Oncol · 2025 BACKGROUND: Cancer chemotherapy is a treatment that systematically kills cancer cells but causes expected side effects, known as chemotherapy-induced toxicities. These toxicities are managed with supportive care medications. This study aimed to determine t ... Full text Link to item Cite

Sub-Saharan African experience of neurosurgical oncology care: challenges and barriers encountered at 7 cancer treatment centers.

Journal Article J Neurosurg · December 1, 2024 OBJECTIVE: Wide disparities in neurosurgical oncology care and treatment outcomes exist globally despite recent improvements in diagnostics and cancer therapy. To better understand the challenges to neurosurgical oncology care in low-resource settings, the ... Full text Link to item Cite

CTIM-01. OUTCOMES AND IMMUNE RESPONSES AFTER PEPTIDE VACCINATION TARGETING HUMAN CYTOMEGALOVIRUS ANTIGEN PP65 IN CHILDREN AND YOUNG ADULTS WITH RECURRENT HIGH-GRADE GLIOMA AND MEDULLOBLASTOMA: RESULTS OF A PHASE 1 TRIAL

Conference Neuro-Oncology · November 11, 2024 AbstractINTRODUCTIONThe human cytomegalovirus (CMV) antigen pp65 is ubiquitously expressed in high-grade glioma (HGG) and medulloblast ... Full text Cite

The socio-cultural contexts shaping health-seeking behaviours among community members regarding childhood cancer in Tanzania: A qualitative study.

Journal Article Pediatr Blood Cancer · November 2024 BACKGROUND: Timely diagnosis of childhood cancer, early hospital presentation and completion of treatment significantly improve outcomes. Unfortunately, in Tanzania, thousands of children die of cancer each year without ever being diagnosed or treated. To ... Full text Link to item Cite

Retrospective analysis of pediatric patients with Burkitt lymphoma treated in Tanzania following the implementation of the 2016 National Treatment Guidelines: Poor outcomes to current standard-of-care therapy.

Journal Article Pediatr Blood Cancer · September 2024 BACKGROUND: Despite the excellent outcomes achieved in the treatment of pediatric Burkitt lymphoma (BL) in high-income countries (HICs), outcomes remain poor in low- and middle-income countries (LMICs). Efforts to improve BL outcomes in Tanzania included t ... Full text Link to item Cite

Outcomes and immune response after peptide vaccination targeting human cytomegalovirus antigen pp65 in children and young adults with recurrent high-grade glioma and medulloblastoma.

Conference JOURNAL OF CLINICAL ONCOLOGY · 2024 Cite

Immunohistochemistry effect on diagnostic reliability for paediatric cancer at Mwanza region, Tanzania: a laboratory descriptive study.

Journal Article Ecancermedicalscience · 2024 INTRODUCTION: In nations with poor and intermediate incomes, cancer is one of the main causes of mortality. Immunohistochemistry (IHC) is crucial for an accurate cancer evaluation, prognosis and treatment decision-making. To use IHC, a significant amount o ... Full text Link to item Cite

Cost Estimates of Brachytherapy Delivery in Northern Tanzania Using Time-Driven Activity Based Costing

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2024 Cite

Establishment of a brain tumor consortium of Africa: Advancing collaborative research and advocacy for brain tumors in Africa

Journal Article Neuro Oncology Advances · January 1, 2024 Background. Brain tumors represent a significant global health challenge, with rising incidence and mortality impacting individuals worldwide and contributing to cancer-related morbidity and mortality. In Africa, this burden is exacerbated by limited acces ... Full text Cite

Swahili translation and cultural adaptation of the pediatric patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE)

Conference Journal of Patient Reported Outcomes · December 1, 2023 Background: The pediatric patient-reported outcomes version of the common terminology criteria for adverse event measure was developed and validated for use in pediatric cancer clinical trials to better capture the symptom experiences through direct self-r ... Full text Cite

Wilms tumor treatment protocol compliance and the influence on outcomes for children in Tanzania.

Journal Article Pediatr Blood Cancer · December 2023 BACKGROUND: Standardized Wilms tumor treatment protocols exist for low- and middle-income countries, but outcomes equivalent to high-income countries are not achieved outside of clinical trials. As Wilms tumor treatment protocols in Africa shift with incre ... Full text Link to item Cite

Development of an Evidence-Based Clinical Tool for Childhood Cancer Survivorship Care in Tanzania

Conference Blood · November 2, 2023 CONCLUSIONSThree in every four childhood cancer survivors experience late effects from treatment. As childhood cancer outcomes improve globally, it is important for providers to screen for these potential la ... Full text Cite

Analysis of Nutrition Status and Outcomes for Pediatric Patients with Burkitt Lymphoma Treated in Mwanza, Tanzania

Conference Blood · November 2, 2023 Introduction: Despite decades of improvement in outcomes for pediatric cancers in High-Income Countries (HICs), outcomes remain incredibly disparate as compared to those achieved in Low- and Middle-Income Countries (LMI ... Full text Cite

Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.

Journal Article Lancet Child Adolesc Health · July 2023 BACKGROUND: Outcomes of recurrent paediatric high-grade glioma are poor, with a median overall survival of less than 6 months. Viral immunotherapy, such as the polio-rhinovirus chimera lerapolturev, is a novel approach for treatment of recurrent paediatric ... Full text Link to item Cite

Swahili translation and cultural adaptation of the pediatric patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE).

Journal Article J Patient Rep Outcomes · June 12, 2023 BACKGROUND: The pediatric patient-reported outcomes version of the common terminology criteria for adverse event measure was developed and validated for use in pediatric cancer clinical trials to better capture the symptom experiences through direct self-r ... Full text Link to item Cite

Childhood and Adolescent Cancer Care at a Tertiary Hospital in Northern Tanzania: A Retrospective Study.

Journal Article JCO Glob Oncol · June 2023 PURPOSE: Over 400,000 children are diagnosed with cancer around the world each year, with over 80% of these children residing in low- and middle-income countries. This study aims to summarize the epidemiology and care patterns of newly diagnosed childhood ... Full text Link to item Cite

Abstract 51: Impacts of the COVID-19 Pandemic on Pediatric and Adolescent Cancer Care in Northern Tanzania

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2023 AbstractPurpose: Low- and middle-income countries (LMICs) have an increasing burden of pediatric cancer cases over recent years. In 2020, the COVID-19 pandemic further strained healthcare systems, presenting ... Full text Cite

Abstract 54: Influence of Neuro Oncology Capacity Development on Diagnosis of Pediatric Primary CNS Tumors in Northern Tanzania

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2023 AbstractPurpose: The diagnosis of CNS tumors requires a multidisciplinary team including oncologists, neurosurgeons, radiologists and pathologists. We review the impact of expanding diagnostic capacity on th ... Full text Cite

Abstract 33: Epidemiology, Diagnosis, and Outcomes of Pediatric Burkitt Lymphoma Patients Treated at Bugando Medical Centre in Mwanza, Tanzania

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2023 AbstractPurpose: Despite the significant improvement in outcomes over the last few decades for the treatment of pediatric Burkitt lymphoma, outcomes in sub-Saharan Africa remain poor, with an approximately 5 ... Full text Cite

Abstract 32: Epidemiological Characteristics and Histopathologic Patterns Cranial-Spinal Tumours (CSTs) at Bugando Medical Centre (BMC) in the Lake Zone Region of Mwanza Tanzania in a Period of 8 Years

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2023 AbstractPurpose: To understand the epidemiological characteristics and histopathologic patterns cranial-spinal tumours (CSTs) at Bugando Medical Centre (BMC) in the lake zone region of Mwanza Tanzania Full text Cite

Abstract 75: Swahili Translation and Cultural Adaptation of the Cancer Stigma Scale (CASS) for Use in the Non-Patient Population in Tanzania

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2023 AbstractPurpose: The Cataldo Cancer Stigma Scale (CASS) was developed to measure patient experienced stigma, and further modified for use in non-patient communities. The aim of this study was to adapt a Swah ... Full text Cite

Abstract 34: Evaluation of Potential Risk for Developing Treatment-Associated Late Effects Among Childhood Cancer Survivors in Northern Tanzania

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2023 AbstractPurpose: Global advancement in pediatric cancer treatment has significantly increased survival rates for children with cancer. Childhood cancer survivors (CCS) now represent a growing population at r ... Full text Cite

Use of Trametinib in Children and Young Adults With Progressive Low-grade Glioma and Glioneuronal Tumors.

Journal Article J Pediatr Hematol Oncol · May 1, 2023 Low-grade gliomas/glioneuronal tumors comprise one-third of all pediatric-type CNS tumors. These tumors are generally caused by activating mutations in the mitogen-activated protein kinase (MAPK) pathway. Targeted drugs, such as trametinib, have shown prom ... Full text Link to item Cite

Access to essential cancer medicines for children: a comparative mixed-methods analysis of availability, price, and health-system determinants in east Africa.

Journal Article Lancet Oncol · May 2023 BACKGROUND: Access to essential childhood cancer medicines is a core determinant of childhood cancer outcomes. Available evidence, although scarce, suggests that access to these medicines is highly variable across countries, particularly in low-income and ... Full text Link to item Cite

Delays in cancer care for children in low-income and middle-income countries: development of a composite vulnerability index.

Journal Article Lancet Glob Health · April 2023 BACKGROUND: Early access to diagnosis and care is essential to improve rates of survival from childhood cancer, particularly in low-income and middle-income countries (LMICs). Composite indices are increasingly used to compare country performance in many h ... Full text Link to item Cite

Determinants of delayed childhood cancer care in low- and middle-income countries: A systematic review.

Journal Article Pediatr Blood Cancer · March 2023 Early access to care is essential to improve survival rates for childhood cancer. This study evaluates the determinants of delays in childhood cancer care in low- and middle-income countries (LMICs) through a systematic review of the literature. We propose ... Full text Link to item Cite

Outcomes from 8 years of cervical cancer screening at a rural screen-and-treat site in northern Tanzania.

Journal Article Int J Gynaecol Obstet · February 2023 OBJECTIVE: To examine screening outcomes for a rural screen-and-treat site as well as the referral completion rate, outreach programming, and screening costs. METHODS: A retrospective cross-sectional analysis of demographic information and screening outcom ... Full text Link to item Cite