Scholars@Duke
Lalita Mazgaeen

Lalita Mazgaeen

Postdoctoral Associate
Neurosurgery, Neuro-Oncology

Selected Publications

IMMU-37. PRE-TREATMENT INNATE INFLAMMATION ASSOCIATES WITH SURVIVAL AFTER POLIO VIROTHERAPY AND CAN BE MODULATED TO SENSITIZE GLIOMAS TO IN SITU VACCINATION

Conference Neuro-Oncology · November 11, 2024 AbstractEarly-stage clinical trials in glioblastoma (GBM) have tested various virotherapy strategies, yet only a subset of patients appear to benefit. We previously demonstrated that a recombinant poliovirus ... Full text Cite

CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation.

Journal Article Science advances · January 2023 Mice with SHP1 proteins, which have a single amino acid substitution from tyrosine-208 residue to asparagine (hereafter Ptpn6spin mice), develop an autoinflammatory disease with inflamed footpads. Genetic crosses to study CD47 function in ... Full text Cite

Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection.

Journal Article ImmunoHorizons · September 2020 Leishmania spp. infection is a global health problem affecting more than 2 million people every year with 300 million at risk worldwide. It is well established that a dominant Th1 response (IFN-γ, a hallmark Th1 cytokine) provides resistance, wherea ... Full text Cite

Neutro"feels" lethal toxin.

Journal Article Journal of leukocyte biology · September 2020 Discussion on lethal toxin-induced acute IL-1β production as dependent on NLRP1b and caspase-1, PAD4, cell-free DNA and neutrophils. ... Full text Cite

Leishmania major degrades murine CXCL1

Journal Article The FASEB Journal · April 2020 Leishmaniasis is a global health problem with an estimated report of 2 million new cases every year. Innate immune system plays a central role in controlling L. major infection by initiating a sign ... Full text Cite

Recent Advances in Lipopolysaccharide Recognition Systems.

Journal Article International journal of molecular sciences · January 2020 Lipopolysaccharide (LPS), commonly known as endotoxin, is ubiquitous and the most-studied pathogen-associated molecular pattern. A component of Gram-negative bacteria, extracellular LPS is sensed by our immune system via the toll-like receptor (TLR)-4. Giv ... Full text Cite

Leishmania major degrades murine CXCL1 - An immune evasion strategy.

Journal Article PLoS neglected tropical diseases · July 2019 Leishmaniasis is a global health problem with an estimated report of 2 million new cases every year and more than 1 billion people at risk of contracting this disease in endemic areas. The innate immune system plays a central role in controlling L. major i ... Full text Cite

Identification and interaction of multiple genes resulting in DDT resistance in the 91-R strain of Drosophila melanogaster by RNAi approaches.

Journal Article Pesticide biochemistry and physiology · October 2018 4,4'-dichlorodiphenyltrichloroethane (DDT) has been re-recommended by the World Health Organization for malaria mosquito control. Previous DDT use has resulted in resistance, and with continued use resistance will likely increase in terms of level and exte ... Full text Cite

Occurrence of amino acid mutation (Ala98Val) of HNF1α in association with type II diabetes.

Journal Article Journal of Nepal Health Research Council · May 2014 BackgroundMaturity onset diabetes of the young type 3 is a monogenic form of diabetes. Gene defects in the Hepatocyte Nuclear Factor -1 alpha (HNF1a) causes MODY3. HNF1a gene located in the chromosome (12q24.2) codes for a transcription factor whi ... Cite