Scholars@Duke
Nwora Lance Okeke

Nwora Lance Okeke

Associate Professor of Medicine
Medicine, Infectious Diseases
lance.okeke@duke.edu
Dept of Medicine, BOX_31255, Durham, NC 27710
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Selected Publications

Cardiology Encounters for Underrepresented Racial and Ethnic Groups with Human Immunodeficiency Virus and Borderline Cardiovascular Disease Risk.

Journal Article J Racial Ethn Health Disparities · June 2024 BACKGROUND: Underrepresented racial and ethnic groups (UREGs) with HIV have a higher risk of cardiovascular disease (CVD) compared with the general population. Referral to a cardiovascular specialist improves CVD risk factor management in high-risk individ ... Full text Link to item Cite

The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk?

Journal Article AIDS Res Hum Retroviruses · May 27, 2024 Climate change poses one of the most significant modern threats to overall human health,especially for vulnerable populations including persons living with HIV (PLWH). In this perspective, we specifically explore the concept of immune resilience in human h ... Full text Link to item Cite

Nurse-Led Strategy to Improve Blood Pressure and Cholesterol Level Among People With HIV: A Randomized Clinical Trial.

Journal Article JAMA Netw Open · March 4, 2024 IMPORTANCE: Despite higher atherosclerotic cardiovascular disease (ASCVD) risk, people with HIV (PWH) experience unique barriers to ASCVD prevention, such as changing models of HIV primary care. OBJECTIVE: To test whether a multicomponent nurse-led strateg ... Full text Open Access Link to item Cite

Disparities in central line-associated bloodstream infection and catheter-associated urinary tract infection rates: An exploratory analysis.

Journal Article Infect Control Hosp Epidemiol · November 2023 This retrospective review of 4-year surveillance data revealed a higher central line-associated bloodstream infection (CLABSI) rate in non-Hispanic Black patients and higher catheter-associated urinary tract infection (CAUTI) rates in Asian and non-Hispani ... Full text Link to item Cite

Evidence2Practice (E2P): Leveraging Implementation Science to Promote Careers in HIV Research Among Students From Historically Black Colleges and Universities.

Journal Article J Acquir Immune Defic Syndr · October 1, 2023 BACKGROUND: The HIV research workforce is not representative of populations most affected by the epidemic. Innovative educational programs are needed to motivate diverse student populations to pursue careers in HIV research. METHODS: The Duke University Ce ... Full text Open Access Link to item Cite

Centers for AIDS Research (CFAR) Diversity, Equity, and Inclusion Pathway Initiative (CDEIPI): Developing Career Pathways for Early-Stage Scholars From Racial and Ethnic Groups Underrepresented in HIV Science and Medicine.

Journal Article J Acquir Immune Defic Syndr · October 1, 2023 BACKGROUND: There is an urgent need to increase diversity among scientific investigators in the HIV research field to be more reflective of communities highly affected by the HIV epidemic. Thus, it is critical to promote the inclusion and advancement of ea ... Full text Link to item Cite

Disparities in Mpox Vaccination Among Priority Populations During the 2022 Outbreak.

Journal Article Open Forum Infect Dis · September 2023 BACKGROUND: The 2022 mpox outbreak disproportionately affected men who have sex with men and persons living with HIV (PLWH). A 2-dose mpox vaccine series was deployed in mid-2022. Structural racism and insurance status may have affected equitable vaccinati ... Full text Link to item Cite

Concurrent Sexually Transmitted Infection Testing Among Patients Tested for Mpox at a Tertiary Healthcare System.

Journal Article Open Forum Infect Dis · August 2023 Coinfection with sexually transmitted infections (STIs) and mpox is common. We evaluated concurrent STI testing among Duke Health patients tested for mpox. We found that most patients tested for mpox were not comprehensively tested for STIs, despite concur ... Full text Link to item Cite

Association of Neighborhood Deprivation With Healthcare Utilization Among Persons With Human Immunodeficiency Virus: A Latent Class Analysis.

Journal Article Open Forum Infect Dis · July 2023 BACKGROUND: We previously identified 3 latent classes of healthcare utilization among people with human immunodeficiency virus (PWH): adherent, nonadherent, and sick. Although membership in the "nonadherent" group was associated with subsequent disengageme ... Full text Link to item Cite

Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE).

Journal Article Clin Infect Dis · June 8, 2023 Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI], .22 to .33 vs +0.17 kg/m2/year; 95% CI, .12 to .23; P = .0 ... Full text Link to item Cite

A survey of South Carolina pharmacists' readiness to prescribe human immunodeficiency virus pre-exposure prophylaxis.

Journal Article J Am Coll Clin Pharm · April 2023 INTRODUCTION: HIV pre-exposure prophylaxis (PrEP) is largely underutilized in the Southern United States. Given their community presence, pharmacists are well positioned to provide PrEP within rural, Southern regions. However, pharmacists' readiness to pre ... Full text Link to item Cite

Development of a Human Immunodeficiency Virus Risk Prediction Model Using Electronic Health Record Data From an Academic Health System in the Southern United States.

Journal Article Clin Infect Dis · January 13, 2023 BACKGROUND: Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) is underutilized in the southern United States. Rapid identification of individuals vulnerable to diagnosis of HIV using electronic health record (EHR)-based tools may augment P ... Full text Link to item Cite

Feasibility, Acceptability, and Preliminary Efficacy of a Gamified Mobile Health Contingency Management Intervention for PrEP Adherence Among Black MSM.

Journal Article AIDS Behav · October 2022 Oral HIV pre-exposure prophylaxis (PrEP) is effective at preventing HIV. However, low adherence is common and undermines these protective effects. This is particularly relevant for groups with disproportionately higher rates of HIV, including Black men who ... Full text Link to item Cite

COVID-19 vaccination intention and activation among health care system employees: A mixed methods study.

Journal Article Vaccine · August 19, 2022 BACKGROUND: Achieving high COVID-19 vaccination rates among employees is necessary to prevent outbreaks in health care settings. The goal of the study was to produce actionable and timely evidence about factors underlying the intention and decisions to obt ... Full text Open Access Link to item Cite

Perspectives of HIV specialists and cardiologists on the specialty referral process for people living with HIV: a qualitative descriptive study.

Journal Article BMC Health Serv Res · May 9, 2022 BACKGROUND: Cardiology care may be beneficial for risk factor management in people living with HIV (PLWH), yet limited information is available about the referral process from the perspectives of HIV specialists and cardiologists. METHODS: We conducted 28 ... Full text Link to item Cite

Understanding Retention in Pre-Exposure Prophylaxis Care in the South: Insights from an Academic HIV Prevention Clinic.

Journal Article AIDS Res Hum Retroviruses · April 2022 HIV pre-exposure prophylaxis (PrEP) is poorly utilized in the southern United States. We examined PrEP retention in care and sexually transmitted infections (STIs) through a retrospective review of the Duke University PrEP Clinic from January 1, 2015 to Oc ... Full text Link to item Cite

COVID-19 Trials: Who Participates and Who Benefits?

Journal Article South Med J · April 2022 OBJECTIVES: The coronavirus disease 2019 (COVID-19) pandemic has disproportionately afflicted vulnerable populations. Older adults, particularly residents of nursing facilities, represent a small percentage of the population but account for 40% of mortalit ... Full text Open Access Link to item Cite

Cardiology Encounters for Underrepresented Racial and Ethnic Groups with Human Immunodeficiency Virus and Borderline Cardiovascular Disease Risk.

Journal Article J Racial Ethn Health Disparities · June 2024 BACKGROUND: Underrepresented racial and ethnic groups (UREGs) with HIV have a higher risk of cardiovascular disease (CVD) compared with the general population. Referral to a cardiovascular specialist improves CVD risk factor management in high-risk individ ... Full text Link to item Cite

The Climate Change Burden on Immune Health: Are Persons Living with HIV More at Risk?

Journal Article AIDS Res Hum Retroviruses · May 27, 2024 Climate change poses one of the most significant modern threats to overall human health,especially for vulnerable populations including persons living with HIV (PLWH). In this perspective, we specifically explore the concept of immune resilience in human h ... Full text Link to item Cite

Nurse-Led Strategy to Improve Blood Pressure and Cholesterol Level Among People With HIV: A Randomized Clinical Trial.

Journal Article JAMA Netw Open · March 4, 2024 IMPORTANCE: Despite higher atherosclerotic cardiovascular disease (ASCVD) risk, people with HIV (PWH) experience unique barriers to ASCVD prevention, such as changing models of HIV primary care. OBJECTIVE: To test whether a multicomponent nurse-led strateg ... Full text Open Access Link to item Cite

Disparities in central line-associated bloodstream infection and catheter-associated urinary tract infection rates: An exploratory analysis.

Journal Article Infect Control Hosp Epidemiol · November 2023 This retrospective review of 4-year surveillance data revealed a higher central line-associated bloodstream infection (CLABSI) rate in non-Hispanic Black patients and higher catheter-associated urinary tract infection (CAUTI) rates in Asian and non-Hispani ... Full text Link to item Cite

Evidence2Practice (E2P): Leveraging Implementation Science to Promote Careers in HIV Research Among Students From Historically Black Colleges and Universities.

Journal Article J Acquir Immune Defic Syndr · October 1, 2023 BACKGROUND: The HIV research workforce is not representative of populations most affected by the epidemic. Innovative educational programs are needed to motivate diverse student populations to pursue careers in HIV research. METHODS: The Duke University Ce ... Full text Open Access Link to item Cite

Centers for AIDS Research (CFAR) Diversity, Equity, and Inclusion Pathway Initiative (CDEIPI): Developing Career Pathways for Early-Stage Scholars From Racial and Ethnic Groups Underrepresented in HIV Science and Medicine.

Journal Article J Acquir Immune Defic Syndr · October 1, 2023 BACKGROUND: There is an urgent need to increase diversity among scientific investigators in the HIV research field to be more reflective of communities highly affected by the HIV epidemic. Thus, it is critical to promote the inclusion and advancement of ea ... Full text Link to item Cite

Disparities in Mpox Vaccination Among Priority Populations During the 2022 Outbreak.

Journal Article Open Forum Infect Dis · September 2023 BACKGROUND: The 2022 mpox outbreak disproportionately affected men who have sex with men and persons living with HIV (PLWH). A 2-dose mpox vaccine series was deployed in mid-2022. Structural racism and insurance status may have affected equitable vaccinati ... Full text Link to item Cite

Concurrent Sexually Transmitted Infection Testing Among Patients Tested for Mpox at a Tertiary Healthcare System.

Journal Article Open Forum Infect Dis · August 2023 Coinfection with sexually transmitted infections (STIs) and mpox is common. We evaluated concurrent STI testing among Duke Health patients tested for mpox. We found that most patients tested for mpox were not comprehensively tested for STIs, despite concur ... Full text Link to item Cite

Association of Neighborhood Deprivation With Healthcare Utilization Among Persons With Human Immunodeficiency Virus: A Latent Class Analysis.

Journal Article Open Forum Infect Dis · July 2023 BACKGROUND: We previously identified 3 latent classes of healthcare utilization among people with human immunodeficiency virus (PWH): adherent, nonadherent, and sick. Although membership in the "nonadherent" group was associated with subsequent disengageme ... Full text Link to item Cite

Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE).

Journal Article Clin Infect Dis · June 8, 2023 Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI], .22 to .33 vs +0.17 kg/m2/year; 95% CI, .12 to .23; P = .0 ... Full text Link to item Cite

A survey of South Carolina pharmacists' readiness to prescribe human immunodeficiency virus pre-exposure prophylaxis.

Journal Article J Am Coll Clin Pharm · April 2023 INTRODUCTION: HIV pre-exposure prophylaxis (PrEP) is largely underutilized in the Southern United States. Given their community presence, pharmacists are well positioned to provide PrEP within rural, Southern regions. However, pharmacists' readiness to pre ... Full text Link to item Cite

Development of a Human Immunodeficiency Virus Risk Prediction Model Using Electronic Health Record Data From an Academic Health System in the Southern United States.

Journal Article Clin Infect Dis · January 13, 2023 BACKGROUND: Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) is underutilized in the southern United States. Rapid identification of individuals vulnerable to diagnosis of HIV using electronic health record (EHR)-based tools may augment P ... Full text Link to item Cite

Feasibility, Acceptability, and Preliminary Efficacy of a Gamified Mobile Health Contingency Management Intervention for PrEP Adherence Among Black MSM.

Journal Article AIDS Behav · October 2022 Oral HIV pre-exposure prophylaxis (PrEP) is effective at preventing HIV. However, low adherence is common and undermines these protective effects. This is particularly relevant for groups with disproportionately higher rates of HIV, including Black men who ... Full text Link to item Cite

COVID-19 vaccination intention and activation among health care system employees: A mixed methods study.

Journal Article Vaccine · August 19, 2022 BACKGROUND: Achieving high COVID-19 vaccination rates among employees is necessary to prevent outbreaks in health care settings. The goal of the study was to produce actionable and timely evidence about factors underlying the intention and decisions to obt ... Full text Open Access Link to item Cite

Perspectives of HIV specialists and cardiologists on the specialty referral process for people living with HIV: a qualitative descriptive study.

Journal Article BMC Health Serv Res · May 9, 2022 BACKGROUND: Cardiology care may be beneficial for risk factor management in people living with HIV (PLWH), yet limited information is available about the referral process from the perspectives of HIV specialists and cardiologists. METHODS: We conducted 28 ... Full text Link to item Cite

Understanding Retention in Pre-Exposure Prophylaxis Care in the South: Insights from an Academic HIV Prevention Clinic.

Journal Article AIDS Res Hum Retroviruses · April 2022 HIV pre-exposure prophylaxis (PrEP) is poorly utilized in the southern United States. We examined PrEP retention in care and sexually transmitted infections (STIs) through a retrospective review of the Duke University PrEP Clinic from January 1, 2015 to Oc ... Full text Link to item Cite

COVID-19 Trials: Who Participates and Who Benefits?

Journal Article South Med J · April 2022 OBJECTIVES: The coronavirus disease 2019 (COVID-19) pandemic has disproportionately afflicted vulnerable populations. Older adults, particularly residents of nursing facilities, represent a small percentage of the population but account for 40% of mortalit ... Full text Open Access Link to item Cite

Progression of cardiac structure and function in people with human immunodeficiency virus.

Journal Article Echocardiography · February 2022 OBJECTIVE: People living with HIV (PLWH) are at increased risk for cardiac dysfunction. It is unknown how their global longitudinal cardiac function, cardiac structure, and other indices of function progress over time. We aimed to characterize the longitud ... Full text Link to item Cite

Perceptions on HIV Pre-Exposure Prophylaxis Among Urgent Care Clinicians in the Southern United States.

Journal Article Curr HIV Res · 2022 BACKGROUND: Underutilization of HIV pre-exposure prophylaxis (PrEP) in the Southern United States (US) is well-documented. Urgent care (UC) centers are positioned as communityfacing access points to PrEP, but the feasibility of integrating PrEP services in ... Full text Link to item Cite

Prevalence and Correlates of Ischemic ECG Findings among Adults With and Without HIV in Tanzania.

Journal Article Glob Heart · 2022 INTRODUCTION: HIV confers increased risk of myocardial infarction (MI), but there has been little study of ischemic electrocardiogram (ECG) findings among people with HIV in sub-Saharan Africa. OBJECTIVES: To compare the prevalence of ischemic ECG findings ... Full text Link to item Cite

Hypertension among adults enrolled in HIV care in northern Tanzania: comorbidities, cardiovascular risk, and knowledge, attitudes and practices.

Journal Article Pan Afr Med J · 2022 CITE THIS ARTICLE: Preeti Manavalan et al. Hypertension among adults enrolled in HIV care in northern Tanzania: comorbidities, cardiovascular risk, and knowledge, attitudes and practices. Pan African Medical Journal. 2022;41(285). 10.11604/pamj.2022.41.285 ... Full text Link to item Cite

Assessment of Obesity and Cardiometabolic Status by Integrase Inhibitor Use in REPRIEVE: A Propensity-Weighted Analysis of a Multinational Primary Cardiovascular Prevention Cohort of People With Human Immunodeficiency Virus.

Journal Article Open Forum Infect Dis · December 2021 BACKGROUND: Emerging data demonstrate that the use of integrase inhibitor (INSTI)-based antiretroviral treatment (ART) is associated with increased weight, but the cardiometabolic health consequences of increased weight remains poorly understood. METHODS: ... Full text Link to item Cite

Awareness and acceptability of HIV pre-exposure prophylaxis (PrEP) among students at two historically Black universities (HBCU): a cross-sectional survey.

Journal Article BMC Public Health · May 19, 2021 BACKGROUND: Despite young African American adults (ages 18-24) being among the highest risk groups for HIV infection, little is known about their awareness of HIV pre-exposure prophylaxis (PrEP) - a once daily pill shown to be > 90% effective in preventing ... Full text Open Access Link to item Cite

Social Disadvantage, Politics, and Severe Acute Respiratory Syndrome Coronavirus 2 Trends: A County-level Analysis of United States Data.

Journal Article Clin Infect Dis · May 18, 2021 BACKGROUND: Understanding the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for public health control efforts. Social, demographic, and political characteristics at the United States (US) county level might be as ... Full text Open Access Link to item Cite

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.

Journal Article Nat Commun · April 15, 2021 Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroquine a ... Full text Open Access Link to item Cite

Preexposure Prophylaxis Outcomes in an Urban Community in North Carolina: Discontinuation of Care and Sexually Transmitted Infections.

Journal Article Sex Transm Dis · March 1, 2021 BACKGROUND: Few studies have examined long-term outcomes among persons who initiate preexposure prophylaxis (PrEP) in the South, including PrEP discontinuation and sexually transmitted infection (STI) rates. METHODS: Care discontinuation (>6 months without ... Full text Link to item Cite

Understanding constraints on integrated care for people with HIV and multimorbid cardiovascular conditions: an application of the Theoretical Domains Framework.

Journal Article Implement Sci Commun · February 12, 2021 BACKGROUND: People with HIV (PWH) experience increased cardiovascular disease (CVD) risk. Many PWH in the USA receive their primary medical care from infectious disease specialists in HIV clinics. HIV care teams may not be fully prepared to provide evidenc ... Full text Open Access Link to item Cite

Endogenous Candida endophthalmitis: Who is really at risk?

Journal Article J Infect · February 2021 OBJECTIVES: The Infectious Disease Society of America recommends that all patients with candidemia undergo a dilated retinal exam to exclude endogenous Candida endophthalmitis. Our objective was to determine if there are significant risk factors in candide ... Full text Link to item Cite

Perspectives of Chronic Disease Management Among Persons with HIV: A Qualitative Study.

Journal Article Patient Prefer Adherence · 2021 INTRODUCTION: Persons with HIV (PWH) are living to advanced age as a result of ART. These epidemiological changes highlight the importance of innovating chronic care delivery of PWH, but there is limited research regarding patient preferences for chronic c ... Full text Link to item Cite

The influence of healthcare financing on cardiovascular disease prevention in people living with HIV.

Journal Article BMC Public Health · November 23, 2020 BACKGROUND: People living with HIV are diagnosed with age-related chronic health conditions, including cardiovascular disease, at higher than expected rates. Medical management of these chronic health conditions frequently occur in HIV specialty clinics by ... Full text Open Access Link to item Cite

Cardiovascular Disease Risk Management in Persons With HIV: Does Clinician Specialty Matter?

Journal Article Open Forum Infect Dis · September 2020 BACKGROUND: The impact of clinician specialty on cardiovascular disease risk factor outcomes among persons with HIV (PWH) is unclear. METHODS: PWH receiving care at 3 Southeastern US academic HIV clinics between January 2014 and December 2016 were retrospe ... Full text Open Access Link to item Cite

Hypertension burden and challenges across the hypertension treatment cascade among adults enrolled in HIV care in northern Tanzania.

Journal Article J Clin Hypertens (Greenwich) · August 2020 Failure to address hypertension among people living with HIV (PLWH) may undermine the significant progress made toward reducing mortality among this high-risk population in sub-Saharan Africa (SSA). Here, the authors report hypertension prevalence, diagnos ... Full text Link to item Cite

Prevention of cardiovascular disease for historically marginalized racial and ethnic groups living with HIV: A narrative review of the literature.

Journal Article Prog Cardiovasc Dis · 2020 Despite developments to improve health in the United States, racial and ethnic disparities persist. These disparities have profound impact on the wellbeing of historically marginalized racial and ethnic groups. This narrative review explores disparities by ... Full text Link to item Cite

Use of a human-centered design approach to adapt a nurse-led cardiovascular disease prevention intervention in HIV clinics.

Journal Article Prog Cardiovasc Dis · 2020 Stakeholder-informed strategies addressing cardiovascular disease (CVD) burden among people living with HIV (PWH) are needed within healthcare settings. This study provides an assessment of how human-centered design (HCD) guided the adaptation of a nurse-l ... Full text Open Access Link to item Cite

Why Do People Living with HIV Adhere to Antiretroviral Therapy and Not Comorbid Cardiovascular Disease Medications? A Qualitative Inquiry.

Journal Article Patient Prefer Adherence · 2020 BACKGROUND: After achieving viral suppression, it is critical for persons living with HIV (PLWH) to focus on prevention of non-AIDS comorbidities such as cardiovascular disease (CVD) in order to enhance their quality of life and longevity of life. Despite ... Full text Open Access Link to item Cite

"It's because I think too much": Perspectives and experiences of adults with hypertension engaged in HIV care in northern Tanzania.

Journal Article PloS one · January 2020 BackgroundHypertension, a leading risk for cardiovascular mortality, is an important co-morbidity among people living with HIV (PLHIV). In Tanzania, hypertension prevalence among PLHIV approaches 20 to 30%. However, most patients are unaware of th ... Full text Cite

Rationale and design of a nurse-led intervention to extend the HIV treatment cascade for cardiovascular disease prevention trial (EXTRA-CVD).

Journal Article Am Heart J · October 2019 Persons living with human immunodeficiency virus (PLHIV) are at increased risk of atherosclerotic cardiovascular disease (ASCVD). In spite of this, uptake of evidence-based clinical interventions for ASCVD risk reduction in the HIV clinic setting is sub-op ... Full text Open Access Link to item Cite

Global Longitudinal Strain and Immune Status in Patients Living With Human Immunodeficiency Virus.

Journal Article Am J Cardiol · September 15, 2019 Improvement in survival in patients living with human immunodeficiency virus (PLHIV) has led to increased prevalence of cardiovascular disease. Whether HIV-associated immune dysfunction is associated with preclinical left ventricular (LV) dysfunction despi ... Full text Link to item Cite

Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient.

Journal Article Open Forum Infect Dis · November 2018 Transmitted drug resistance to the integrase strand transfer inhibitor (INSTI) class of antiretrovirals is very rare. We present a case of a treatment-naive female patient with human immunodeficiency virus harboring resistance to all INSTIs, including bict ... Full text Open Access Link to item Cite

Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort.

Journal Article J Card Fail · August 2018 OBJECTIVE: The aim of this work was to investigate determinants of structural myocardial abnormalities in persons living with human immunodeficiency virus (PLWH). METHODS AND RESULTS: We reviewed archived transthoracic echocardiograms (TTEs) performed on P ... Full text Link to item Cite

Prevalence and transmission dynamics of HIV-1 transmitted drug resistance in a southeastern cohort

Journal Article Open Forum Infectious Diseases · August 1, 2018 Background. Transmitted drug resistance (TDR) compromises clinical management and outcomes. Transmitted drug resistance surveillance and identification of growing transmission clusters are needed in the Southeast, the epicenter of the US HIV epidemic. Our ... Full text Cite

An educational initiative in response to identified PrEP prescribing needs among PCPs in the Southern U.S.

Journal Article AIDS Care · May 2018 Pre-exposure prophylaxis (PrEP) is an effective HIV prevention method, but many primary care physicians (PCPs) have not incorporated PrEP into practice. While PrEP may be a key strategy to reducing high HIV transmission rates in the southern US, knowledge ... Full text Link to item Cite

Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.

Journal Article Metabolomics · March 2018 INTRODUCTION: Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking. METHODS: Using tandem flow injec ... Full text Link to item Cite

Lower likelihood of cardiac procedures after acute coronary syndrome in patients with human immunodeficiency virus/acquired immunodeficiency syndrome.

Journal Article Medicine (Baltimore) · February 2018 Cardiovascular disease (CVD) is an increasing cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected adults; however, this population may be less likely to receive interventions during hospitalization for acute coronary syndrome (A ... Full text Open Access Link to item Cite

Statin Utilization and Recommendations Among HIV- and HCV-infected Veterans: A Cohort Study.

Journal Article Clin Infect Dis · August 1, 2016 BACKGROUND: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections are associated with increased risk of cardiovascular disease (CVD). The potential impact of recently updated cholesterol guidelines on treatment of HIV- and HCV-infected ... Full text Link to item Cite

Hypertension Among HIV-infected Patients in Clinical Care, 1996-2013.

Journal Article Clin Infect Dis · July 15, 2016 Featured Publication BACKGROUND: Persons infected with human immunodeficiency virus (HIV) are at higher risk for major cardiovascular disease (CVD) events than uninfected persons. Understanding the epidemiology of major traditional CVD risk determinants, particularly hypertens ... Full text Link to item Cite

History of AIDS in HIV-Infected Patients Is Associated With Higher In-Hospital Mortality Following Admission for Acute Myocardial Infarction and Stroke.

Journal Article J Infect Dis · June 15, 2016 BACKGROUND: Although human immunodeficiency virus (HIV)-infected persons are at increased risk for major cardiovascular events, short-term prognosis after these events is unclear. METHODS: To determine the association between HIV infection and acute myocar ... Full text Link to item Cite

Coronary artery disease risk reduction in HIV-infected persons: a comparative analysis.

Journal Article AIDS Care · 2016 Despite an increased risk of coronary artery disease (CAD) in persons infected with human immunodeficiency virus (HIV), few data are available on primary prevention of CAD in this population. In this retrospective cohort study, HIV-infected patients treate ... Full text Link to item Cite

Enhancing linkage and retention in HIV care: a review of interventions for highly resourced and resource-poor settings.

Journal Article Curr HIV/AIDS Rep · December 2014 Given the widespread availability of effective antiretroviral therapy, engagement of HIV-infected persons in care is a global priority. We reviewed 51 studies, published in the past decade, assessing strategies for improving linkage to and retention in HIV ... Full text Link to item Cite

Treatment of syphilis: a systematic review.

Journal Article JAMA · November 12, 2014 IMPORTANCE: The incidence of syphilis in the United States is increasing; it is estimated that more than 55,000 new infections will occur in 2014. Treatment regimens are controversial, especially in specific populations, and assessing treatment response ba ... Full text Link to item Cite

Role of raltegravir in the management of HIV-1 infection

Journal Article HIV/AIDS - Research and Palliative Care · July 15, 2011 The development of multiple agents with potent antiretroviral activity against HIV has ushered in a new age of optimism in the management of patients infected with the virus. However, the viruses’ dynamic ability to develop resistance against these agents ... Full text Cite

Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis.

Journal Article Arthritis Res Ther · 2008 INTRODUCTION: There is increasing evidence that autoantibodies and immune complexes (ICs) contribute to synovitis in rheumatoid arthritis (RA), yet the autoantigens incorporated in ICs in RA remain incompletely characterised. METHODS: We used the C1q prote ... Full text Link to item Cite

Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus.

Journal Article Arthritis Rheum · June 2005 OBJECTIVE: Proteolytic autoantigen cleavage by the serine protease granzyme B has been implicated in the development of systemic autoimmune disease; however, there has been no conclusive demonstration of a pathogenic role for granzyme B in autoimmunity. In ... Full text Link to item Cite