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History of AIDS in HIV-Infected Patients Is Associated With Higher In-Hospital Mortality Following Admission for Acute Myocardial Infarction and Stroke.

Publication ,  Journal Article
Okeke, NL; Hicks, CB; McKellar, MS; Fowler, VG; Federspiel, JJ
Published in: J Infect Dis
June 15, 2016

BACKGROUND: Although human immunodeficiency virus (HIV)-infected persons are at increased risk for major cardiovascular events, short-term prognosis after these events is unclear. METHODS: To determine the association between HIV infection and acute myocardial infarction (AMI) and stroke outcomes, we analyzed hospital discharge data from the Nationwide Inpatient Sample (NIS) between 2002 and 2012. Multivariable logistic regression was used to evaluate the association between HIV infection and in-hospital death after AMI or stroke. RESULTS: Overall, 18 369 785 AMI/stroke hospitalizations were included in the analysis. Patients with a history of AIDS were significantly more likely than uninfected patients to die during hospitalization after admission for AMI or stroke (odds ratio, 3.03 [95% confidence interval {CI}, 1.71-5.38] for AMI and 2.59 [95% CI, 1.97-3.41] for stroke). Additionally, patients with AIDS were more likely than HIV-uninfected patients to be discharged to nonhospital inpatient facilities after admission for AMI (OR, 3.14 [95% CI, 1.72-5.74]) or stroke (OR, 1.45; 95% CI, 1.12-1.87). There was a minimal difference in either outcome between HIV-infected patients without a history of AIDS and uninfected patients. CONCLUSIONS: Patients with a history of AIDS were significantly more likely than uninfected patients to die during hospitalization after admission for AMI or stroke. This disparity was not observed when infected patients without a history of AIDS were compared to uninfected patients, implying that preserving immune function may improve cardiovascular outcomes in HIV-infected persons.

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

June 15, 2016

Volume

213

Issue

12

Start / End Page

1955 / 1961

Location

United States

Related Subject Headings

  • Stroke
  • Prognosis
  • Myocardial Infarction
  • Middle Aged
  • Microbiology
  • Male
  • Logistic Models
  • Humans
  • Hospitalization
  • Hospital Mortality
 

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Okeke, N. L., Hicks, C. B., McKellar, M. S., Fowler, V. G., & Federspiel, J. J. (2016). History of AIDS in HIV-Infected Patients Is Associated With Higher In-Hospital Mortality Following Admission for Acute Myocardial Infarction and Stroke. J Infect Dis, 213(12), 1955–1961. https://doi.org/10.1093/infdis/jiw082
Okeke, Nwora Lance, Charles B. Hicks, Mehri S. McKellar, Vance G. Fowler, and Jerome J. Federspiel. “History of AIDS in HIV-Infected Patients Is Associated With Higher In-Hospital Mortality Following Admission for Acute Myocardial Infarction and Stroke.J Infect Dis 213, no. 12 (June 15, 2016): 1955–61. https://doi.org/10.1093/infdis/jiw082.
Okeke NL, Hicks CB, McKellar MS, Fowler VG, Federspiel JJ. History of AIDS in HIV-Infected Patients Is Associated With Higher In-Hospital Mortality Following Admission for Acute Myocardial Infarction and Stroke. J Infect Dis. 2016 Jun 15;213(12):1955–61.
Okeke, Nwora Lance, et al. “History of AIDS in HIV-Infected Patients Is Associated With Higher In-Hospital Mortality Following Admission for Acute Myocardial Infarction and Stroke.J Infect Dis, vol. 213, no. 12, June 2016, pp. 1955–61. Pubmed, doi:10.1093/infdis/jiw082.
Okeke NL, Hicks CB, McKellar MS, Fowler VG, Federspiel JJ. History of AIDS in HIV-Infected Patients Is Associated With Higher In-Hospital Mortality Following Admission for Acute Myocardial Infarction and Stroke. J Infect Dis. 2016 Jun 15;213(12):1955–1961.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

June 15, 2016

Volume

213

Issue

12

Start / End Page

1955 / 1961

Location

United States

Related Subject Headings

  • Stroke
  • Prognosis
  • Myocardial Infarction
  • Middle Aged
  • Microbiology
  • Male
  • Logistic Models
  • Humans
  • Hospitalization
  • Hospital Mortality