Lars Martin Wagner | Scholars@Duke

Lars Martin Wagner
Professor of Pediatrics

I am a pediatric oncologist with a clinical and research focus on the care of adolescents and young adults with sarcoma. I have led multiple institutional and national clinical trials exploring new therapies for patients with recurrent sarcoma, and am interested in new drug development and identification of predictive biomarkers.

Current Research Interests

I am a clinical researcher with interest in the care of children, adolescents, and young adults with solid tumors. More specifically, I am interested in developing new therapies for patients with recurrent sarcoma.

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2021
Chief, Division of Hematology/Oncology, Pediatrics, Hematology-Oncology, Pediatrics 2018
Member of the Duke Cancer Institute of the, Duke Cancer Institute, Institutes and Centers 2018

Contact Information

lars.wagner@duke.edu

Background
Education, Training, & Certifications
- Hematology/Oncology Fellowship, St Jude Children's Hospital, University of Tennessee Health Science Center 1998 - 2001
- Residency, Pediatrics, University of Tennessee Health Science Center 1991 - 1994
- M.D., University of Kentucky, College of Medicine 1991
Previous Appointments & Affiliations
- Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2018 - 2020
- Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2018
Leadership & Clinical Positions at Duke
- Chief, Division of Pediatric Hematology/Oncology
Research
Selected Grants
- VAL-10-001: Pilot Pharmacokinetic Study of VAL-413 in Patients with Recurrent Pediatric Solid Tumors awarded by Valent Technologies, LLC 2022 - 2026
- NCI Community Oncology Research Program (NCORP) Research Base Grant awarded by Public Health Institute 2021 - 2025
- Cookies for Kids' Cancer Supplmental PCR awarded by Children's Oncology Group 2022 - 2025
- Project: EveryChild (APEC1481) awarded by Children's Oncology Group 2022 - 2025
- St. Baldrick's Foundation Supplement PCR awarded by Children's Oncology Group 2022 - 2025
- Blood Based Biomarkers for Minimal Residual Disease Detection in Pediatric Sarcomas awarded by H. Lee Moffitt Cancer Center & Research Institute 2020 - 2025
- Per Case Reimbursement : NIH National Clinical Trials Network (NCTN) awarded by Public Health Institute 2021 - 2025
- Workload Intensity NIH National Clinical Trials Network (NCTN) awarded by Public Health Institute 2021 - 2025
- Project: One Time EOY, Integrated BIQSFP AAML1031- Echocardiogram Reports and Images awarded by Children's Hospital of Philadelphia 2019 - 2025
- Improving Symptom Management for Adolescents and Young Adults with Advanced Cancer: Development and Pilot Testing of a Novel Intervention awarded by National Institutes of Health 2022 - 2024
- ACNS1831 awarded by Public Health Institute 2022 - 2024
- Modeling tumor heterogeneity and therapy resistance in osteosarcoma using patient-derived organoids awarded by Hyundai Hope on Wheels 2021 - 2023
- PEPCTN_NonCoreStudyStartup_WLI awarded by Public Health Institute 2021 - 2023
- PEPCTN_PCR awarded by Public Health Institute 2021 - 2023
- NIH COG Pediatric Early Phase Clinical Trial Network Grant (PEP-CTN) awarded by Children's Hospital of Philadelphia 2020 - 2023
- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO) awarded by Atrium Health 2021 - 2023
- A Phase Ib/II Study to Evaluate the Safety, Feasibility and Efficacy of Nivolumab or Nivolumab in Combination with 5-Azacytidine in Patients with Recurrent, Resectable Osteosarcoma awarded by H. Lee Moffitt Cancer Center & Research Institute 2021 - 2023
- NPFC Sunshine Project awarded by National Pediatric Cancer Foundation, Inc. 2020 - 2023
- Longitudinal, multimodal assessment of neuropsychological functioning in children diagnosed with high-risk lymphoblastic leukemia (HR-ALL): Using early changes to predict later impairment (ALTE07C1) awarded by Children's Hospital of Philadelphia 2022 - 2023
- BIQSFP Year 9_PCR ACNS1831 AR62266 awarded by Public Health Institute 2022 - 2023
- A Multi-Center Phase III, Randomized, Open-Label Trial of Vigil (bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in combination with Irinotecan and Temozolomide as a Second-Line Regimen for Ewing's Sarcoma (CL-PTL-130) awarded by Gradalis, Inc. 2019 - 2023
- NCI Community Oncology Research Program (NCORP) Research Base Grant awarded by Children's Hospital of Philadelphia 2014 - 2022
- Evolutionary Inspired Therapy for Newly Diagnosed, Metastatic, Fusion Positive Rhabdomyosarcoma awarded by H. Lee Moffitt Cancer Center & Research Institute 2020 - 2022
- Implementing Family Psychosocial Risk Screening for Pediatric Health Equity awarded by Nemours 2021
- Per Case Reimbursement : NIH National Clinical Trials Network (NCTN) awarded by Children's Hospital of Philadelphia 2014 - 2021
- Workload Intensity NIH National Clinical Trials Network (NCTN) awarded by Children's Hospital of Philadelphia 2014 - 2021
- AALL1131 Supplemental PCR awarded by Children's Hospital of Philadelphia 2020 - 2021
- Specimen Banking Supplements awarded by Children's Hospital of Philadelphia 2020 - 2021
External Relationships
- Jazz Pharmaceuticals
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Yang, Jichen, Laura C. Page, Lars Wagner, Benjamin Wildman-Tobriner, Logan Bisset, Donald Frush, and Maciej A. Mazurowski. “Thyroid Nodules on Ultrasound in Children and Young Adults: Comparison of Diagnostic Performance of Radiologists' Impressions, ACR TI-RADS, and a Deep Learning Algorithm.” Ajr Am J Roentgenol 220, no. 3 (March 2023): 408–17. https://doi.org/10.2214/AJR.22.28231.
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  - Young, Lyndsay E. A., Lindsey R. Conroy, Harrison A. Clarke, Tara R. Hawkinson, Kayli E. Bolton, William C. Sanders, Josephine E. Chang, et al. “In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues.” Embo Mol Med 14, no. 11 (November 8, 2022): e16029. https://doi.org/10.15252/emmm.202216029.
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  - Erker, Craig, Adam Lane, Brooklyn Chaney, Sarah Leary, Jane E. Minturn, Ute Bartels, Roger J. Packer, et al. “Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry.” Neuro Oncol 24, no. 1 (January 5, 2022): 141–52. https://doi.org/10.1093/neuonc/noab140.
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  - Dorfman, Caroline S., Juliann M. Stalls, Coleman Mills, Shannon Voelkel, Mallori Thompson, Kelly S. Acharya, Karen C. Baker, et al. “Addressing Barriers to Fertility Preservation for Cancer Patients: The Role of Oncofertility Patient Navigation.” Journal of Oncology Navigation & Survivorship 12, no. 10 (October 2021): 332–48.
  - Just, Marissa A., David Van Mater, and Lars M. Wagner. “Receptor tyrosine kinase inhibitors for the treatment of osteosarcoma and Ewing sarcoma.” Pediatr Blood Cancer 68, no. 8 (August 2021): e29084. https://doi.org/10.1002/pbc.29084.
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  - Bellantoni, Andrew J., and Lars M. Wagner. “Pursuing Precision: Receptor Tyrosine Kinase Inhibitors for Treatment of Pediatric Solid Tumors.” Cancers (Basel) 13, no. 14 (July 14, 2021). https://doi.org/10.3390/cancers13143531.
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  - Davis, J. T., and L. M. Wagner. “Imaging of childhood urologic cancers: Current approaches and new advances.” Translational Andrology and Urology 9, no. 5 (October 1, 2020): 2348–57. https://doi.org/10.21037/tau-19-839.
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  - Oesterheld, Javier E., Damon R. Reed, Bhuvana A. Setty, Michael S. Isakoff, Patrick Thompson, Hong Yin, Masanori Hayashi, et al. “Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.” Pediatr Blood Cancer 67, no. 7 (July 2020): e28370. https://doi.org/10.1002/pbc.28370.
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  - Reed, Damon R., Jonathan Metts, Mariyah Pressley, Brooke L. Fridley, Masanori Hayashi, Michael S. Isakoff, David M. Loeb, et al. “An evolutionary framework for treating pediatric sarcomas.” Cancer 126, no. 11 (June 2020): 2577–87. https://doi.org/10.1002/cncr.32777.
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  - Wagner, Lars M. “Sarcoma as the Prototype Disease for Adolescent and Young Adult Programs.” J Oncol Pract 15, no. 5 (May 2019): 249–50. https://doi.org/10.1200/JOP.19.00145.
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  - Van Mater, David, and Lars Wagner. “Management of recurrent Ewing sarcoma: challenges and approaches.” Onco Targets Ther 12 (2019): 2279–88. https://doi.org/10.2147/OTT.S170585.
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  - Wedekind, Mary F., Lars M. Wagner, and Timothy P. Cripe. “Immunotherapy for osteosarcoma: Where do we go from here?” Pediatr Blood Cancer 65, no. 9 (September 2018): e27227. https://doi.org/10.1002/pbc.27227.
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  - Wagner, Lars M., John S. Myseros, Douglas E. Lukins, Christi M. Willen, and Roger J. Packer. “Targeted therapy for infants with diencephalic syndrome: A case report and review of management strategies.” Pediatr Blood Cancer 65, no. 5 (May 2018): e26917. https://doi.org/10.1002/pbc.26917.
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  - Hoffman, Lindsey M., Maryam Fouladi, James Olson, Vinay M. Daryani, Clinton F. Stewart, Cynthia Wetmore, Mehmet Kocak, et al. “Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study.” Childs Nerv Syst 31, no. 8 (August 2015): 1283–89. https://doi.org/10.1007/s00381-015-2725-3.
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  - Wagner, Lars M. “Fifteen years of irinotecan therapy for pediatric sarcoma: where to next?” Clin Sarcoma Res 5 (2015): 20. https://doi.org/10.1186/s13569-015-0035-x.
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  - Wagner, Lars M., Roger E. McLendon, K Jin Yoon, Brian D. Weiss, Catherine A. Billups, and Mary K. Danks. “Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.” Clin Cancer Res 13, no. 18 Pt 1 (September 15, 2007): 5418–25. https://doi.org/10.1158/1078-0432.CCR-07-0418.
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- Conference Papers
  - Zachman, Derek, Laurie Graves, Chelse Sanborn, Sarah Sullivan, Susan Kreissman, Jennifer Rothman, and Lars Wagner. “USE OF A RAPID HYDRATION PROTOCOL FOR PEDIATRIC ONCOLOGY PATIENTS RECEIVING NEPHROTOXIC CHEMOTHERAPY.” In Pediatric Blood & Cancer, Vol. 69, 2022.
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  - Brown, Dennis, Jeffrey Bacha, Lars Wagner, Markos Leggas, Sarath Kanekal, Lorena Lopez, and Neil Sankar. “A PILOT CLINICAL TRIAL OF OROTECAN (VAL-413), A NOVEL ORAL DOSAGE FORMULATION OF IRINOTECAN: IMPLICATIONS FOR PEDIATRIC BRAIN TUMORS.” In Neuro Oncology, 22:60–60, 2020.
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  - Fouladi, Maryam, James Olson, Clinton Stewart, Mehmet Kocak, Arzu Onar-Thomas, Lars Wagner, Roger Packer, et al. “A PHASE I TRIAL OF MK-0752 IN PEDIATRIC PATIENTS WITH RECURRENT OR REFRACTORY CNS MALIGNANCIES: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY.” In Neuro Oncology, 14:115–115. OXFORD UNIV PRESS INC, 2012.
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Education, Training, & Certifications

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers