Overview
I am a pediatric oncologist with a clinical and research focus on the care of adolescents and young adults with sarcoma. I have led multiple institutional and national clinical trials exploring new therapies for patients with recurrent sarcoma, and am interested in new drug development and identification of predictive biomarkers.
Current Appointments & Affiliations
Professor of Pediatrics
·
2021 - Present
Pediatrics, Hematology-Oncology,
Pediatrics
Chief, Division of Hematology/Oncology
·
2018 - Present
Pediatrics, Hematology-Oncology,
Pediatrics
Member of the Duke Cancer Institute
·
2018 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Phase II Trial of Gemcitabine and Nab-Paclitaxel for Recurrent Osteosarcoma with Serial Monitoring Using Liquid Biopsy: A Report from the National Pediatric Cancer Foundation.
Journal Article Clin Cancer Res · December 2, 2024 PURPOSE: The combination of gemcitabine and docetaxel is often used to treat patients with recurrent osteosarcoma. Nab-paclitaxel has preclinical activity against osteosarcoma and is potentially less myelosuppressive than docetaxel. We conducted a prospect ... Full text Link to item CiteImpact of Duffy-associated neutrophil count on maintenance chemotherapy management in a child with acute lymphoblastic leukemia.
Journal Article Pediatr Blood Cancer · December 2024 Full text Link to item CiteUsing Crowdfunding Campaigns to Examine Financial Toxicity and Logistical Burdens Facing Families of Children With Wilms Tumor.
Journal Article J Surg Res · November 2023 INTRODUCTION: Treatment for pediatric solid tumors is often intense and multidisciplinary and can create a substantial financial burden for families. Assessing these burdens, termed the financial toxicity of treatment, can be difficult. Using Wilms tumor a ... Full text Link to item CiteRecent Grants
JZP712-101: A phase 1/2, open-label study to evaluate the safety, tolerability, pharmacokinetics (PK), recommended phase 2 dose (RP2D), and efficacy
Clinical TrialPrincipal Investigator · Awarded by Jazz Pharmaceuticals · 2024 - 2027VAL-10-001: Pilot Pharmacokinetic Study of VAL-413 in Patients with Recurrent Pediatric Solid Tumors
Clinical TrialPrincipal Investigator · Awarded by Valent Technologies, LLC · 2022 - 2026Offering Hope to Pediatric Cancer Patients Through Research and Psychosocial Support
Institutional SupportPrincipal Investigator · Awarded by Hyundai Hope on Wheels · 2025 - 2025View All Grants
Education, Training & Certifications
University of Kentucky, College of Medicine ·
1991
M.D.