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Lars Martin Wagner

Professor of Pediatrics
Pediatrics, Hematology-Oncology

Selected Publications


Using Crowdfunding Campaigns to Examine Financial Toxicity and Logistical Burdens Facing Families of Children With Wilms Tumor.

Journal Article The Journal of surgical research · November 2023 IntroductionTreatment for pediatric solid tumors is often intense and multidisciplinary and can create a substantial financial burden for families. Assessing these burdens, termed the financial toxicity of treatment, can be difficult. Using Wilms ... Full text Cite

Pediatric renal malignancy diagnosis is associated with significant burden of care for families.

Journal Article Pediatr Blood Cancer · June 19, 2023 BACKGROUND AND OBJECTIVES: New childhood cancer diagnoses require timely, complex care coordination and cause considerable logistic burden for families. We used renal tumors as a model to examine healthcare utilization and cost following new solid tumor di ... Full text Link to item Cite

Risk of Surgical Intervention in Children with Diagnoses of Cancer and Preoperative Malnutrition: A National Analysis.

Journal Article Journal of pediatric surgery · June 2023 BackgroundPerioperative nutrition is a critical component of appropriate healing and recovery after surgery. We sought to identify perioperative risk in children with cancer and low preoperative hypoalbuminemia undergoing surgical intervention. Full text Cite

Thyroid Nodules on Ultrasound in Children and Young Adults: Comparison of Diagnostic Performance of Radiologists' Impressions, ACR TI-RADS, and a Deep Learning Algorithm.

Journal Article AJR Am J Roentgenol · March 2023 BACKGROUND. In current clinical practice, thyroid nodules in children are generally evaluated on the basis of radiologists' overall impressions of ultrasound images. OBJECTIVE. The purpose of this article is to compare the diagnostic performance of radiolo ... Full text Link to item Cite

In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues.

Journal Article EMBO Mol Med · November 8, 2022 Glycogen dysregulation is a hallmark of aging, and aberrant glycogen drives metabolic reprogramming and pathogenesis in multiple diseases. However, glycogen heterogeneity in healthy and diseased tissues remains largely unknown. Herein, we describe a method ... Full text Link to item Cite

Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry.

Journal Article Neuro Oncol · January 5, 2022 BACKGROUND: Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristi ... Full text Link to item Cite

Addressing Barriers to Fertility Preservation for Cancer Patients: The Role of Oncofertility Patient Navigation.

Journal Article Journal of oncology navigation & survivorship · October 2021 BackgroundInfertility is a common late effect for cancer survivors. Whereas assisted reproductive technology has made it possible for survivors to take steps to preserve fertility before starting treatment, only a minority of patients proceed with ... Cite

Receptor tyrosine kinase inhibitors for the treatment of osteosarcoma and Ewing sarcoma.

Journal Article Pediatr Blood Cancer · August 2021 Adjuvant chemotherapy for osteosarcoma and Ewing sarcoma consists of conventional cytotoxic regimens that have changed little over the past decades. There is an urgent need for agents that are more effective and have less long-term toxicity. Receptor tyros ... Full text Link to item Cite

Pursuing Precision: Receptor Tyrosine Kinase Inhibitors for Treatment of Pediatric Solid Tumors.

Journal Article Cancers (Basel) · July 14, 2021 Receptor tyrosine kinases are critical for the growth and proliferation of many different cancers and therefore represent a potential vulnerability that can be therapeutically exploited with small molecule inhibitors. Over forty small molecule inhibitors a ... Full text Link to item Cite

Imaging of childhood urologic cancers: Current approaches and new advances

Journal Article Translational Andrology and Urology · October 1, 2020 Urologic tumors make up approximately 10% of all pediatric cancers, and include a variety of different histologies and imaging considerations. In this review, we discuss standard radiologic approaches for children with tumors arising in the genitourinary s ... Full text Cite

Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.

Journal Article Pediatr Blood Cancer · July 2020 BACKGROUND: The combination of gemcitabine and docetaxel is often used to treat patients with recurrent sarcoma. Nab-paclitaxel is a taxane modified to improve drug exposure and increase intratumoral accumulation and, in combination with gemcitabine, is st ... Full text Link to item Cite

An evolutionary framework for treating pediatric sarcomas.

Journal Article Cancer · June 1, 2020 Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered. ... Full text Link to item Cite

Management of recurrent Ewing sarcoma: challenges and approaches.

Journal Article Onco Targets Ther · 2019 Although many patients with newly diagnosed Ewing sarcoma can become long-term survivors, relapse remains an important clinical problem for which there is no standard approach. Several prognostic factors have been identified, and these may help guide patie ... Full text Link to item Cite

Immunotherapy for osteosarcoma: Where do we go from here?

Journal Article Pediatr Blood Cancer · September 2018 Osteosarcoma is the most common bone tumor in children and young adults, with few advances in survival and treatment, especially for metastatic disease, in the last 30 years. Recently, immunotherapy has begun to show promise in various adult cancers, but t ... Full text Link to item Cite

Using Crowdfunding Campaigns to Examine Financial Toxicity and Logistical Burdens Facing Families of Children With Wilms Tumor.

Journal Article The Journal of surgical research · November 2023 IntroductionTreatment for pediatric solid tumors is often intense and multidisciplinary and can create a substantial financial burden for families. Assessing these burdens, termed the financial toxicity of treatment, can be difficult. Using Wilms ... Full text Cite

Pediatric renal malignancy diagnosis is associated with significant burden of care for families.

Journal Article Pediatr Blood Cancer · June 19, 2023 BACKGROUND AND OBJECTIVES: New childhood cancer diagnoses require timely, complex care coordination and cause considerable logistic burden for families. We used renal tumors as a model to examine healthcare utilization and cost following new solid tumor di ... Full text Link to item Cite

Risk of Surgical Intervention in Children with Diagnoses of Cancer and Preoperative Malnutrition: A National Analysis.

Journal Article Journal of pediatric surgery · June 2023 BackgroundPerioperative nutrition is a critical component of appropriate healing and recovery after surgery. We sought to identify perioperative risk in children with cancer and low preoperative hypoalbuminemia undergoing surgical intervention. Full text Cite

Thyroid Nodules on Ultrasound in Children and Young Adults: Comparison of Diagnostic Performance of Radiologists' Impressions, ACR TI-RADS, and a Deep Learning Algorithm.

Journal Article AJR Am J Roentgenol · March 2023 BACKGROUND. In current clinical practice, thyroid nodules in children are generally evaluated on the basis of radiologists' overall impressions of ultrasound images. OBJECTIVE. The purpose of this article is to compare the diagnostic performance of radiolo ... Full text Link to item Cite

In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues.

Journal Article EMBO Mol Med · November 8, 2022 Glycogen dysregulation is a hallmark of aging, and aberrant glycogen drives metabolic reprogramming and pathogenesis in multiple diseases. However, glycogen heterogeneity in healthy and diseased tissues remains largely unknown. Herein, we describe a method ... Full text Link to item Cite

Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry.

Journal Article Neuro Oncol · January 5, 2022 BACKGROUND: Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristi ... Full text Link to item Cite

Addressing Barriers to Fertility Preservation for Cancer Patients: The Role of Oncofertility Patient Navigation.

Journal Article Journal of oncology navigation & survivorship · October 2021 BackgroundInfertility is a common late effect for cancer survivors. Whereas assisted reproductive technology has made it possible for survivors to take steps to preserve fertility before starting treatment, only a minority of patients proceed with ... Cite

Receptor tyrosine kinase inhibitors for the treatment of osteosarcoma and Ewing sarcoma.

Journal Article Pediatr Blood Cancer · August 2021 Adjuvant chemotherapy for osteosarcoma and Ewing sarcoma consists of conventional cytotoxic regimens that have changed little over the past decades. There is an urgent need for agents that are more effective and have less long-term toxicity. Receptor tyros ... Full text Link to item Cite

Pursuing Precision: Receptor Tyrosine Kinase Inhibitors for Treatment of Pediatric Solid Tumors.

Journal Article Cancers (Basel) · July 14, 2021 Receptor tyrosine kinases are critical for the growth and proliferation of many different cancers and therefore represent a potential vulnerability that can be therapeutically exploited with small molecule inhibitors. Over forty small molecule inhibitors a ... Full text Link to item Cite

Imaging of childhood urologic cancers: Current approaches and new advances

Journal Article Translational Andrology and Urology · October 1, 2020 Urologic tumors make up approximately 10% of all pediatric cancers, and include a variety of different histologies and imaging considerations. In this review, we discuss standard radiologic approaches for children with tumors arising in the genitourinary s ... Full text Cite

Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.

Journal Article Pediatr Blood Cancer · July 2020 BACKGROUND: The combination of gemcitabine and docetaxel is often used to treat patients with recurrent sarcoma. Nab-paclitaxel is a taxane modified to improve drug exposure and increase intratumoral accumulation and, in combination with gemcitabine, is st ... Full text Link to item Cite

An evolutionary framework for treating pediatric sarcomas.

Journal Article Cancer · June 1, 2020 Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered. ... Full text Link to item Cite

Management of recurrent Ewing sarcoma: challenges and approaches.

Journal Article Onco Targets Ther · 2019 Although many patients with newly diagnosed Ewing sarcoma can become long-term survivors, relapse remains an important clinical problem for which there is no standard approach. Several prognostic factors have been identified, and these may help guide patie ... Full text Link to item Cite

Immunotherapy for osteosarcoma: Where do we go from here?

Journal Article Pediatr Blood Cancer · September 2018 Osteosarcoma is the most common bone tumor in children and young adults, with few advances in survival and treatment, especially for metastatic disease, in the last 30 years. Recently, immunotherapy has begun to show promise in various adult cancers, but t ... Full text Link to item Cite

Targeted therapy for infants with diencephalic syndrome: A case report and review of management strategies.

Journal Article Pediatr Blood Cancer · May 2018 Young children with emaciation caused by a hypothalamic glioma are considered to have diencephalic syndrome (DS), which is often poorly controlled with conventional treatment. We describe an infant with DS whose tumor progressed following chemotherapy. Bio ... Full text Link to item Cite

Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study.

Journal Article Childs Nerv Syst · August 2015 PURPOSE: Amplification and high levels of NOTCH ligand expression have been identified in several types of pediatric brain tumors. A phase I trial of weekly MK-0752, an oral inhibitor of gamma-secretase, was conducted in children with recurrent central ner ... Full text Link to item Cite

Fifteen years of irinotecan therapy for pediatric sarcoma: where to next?

Journal Article Clin Sarcoma Res · 2015 Over the past 15 years, irinotecan has emerged as an important agent for treating pediatric sarcoma patients. This review summarizes the activity noted in previous studies, and outlines current issues regarding scheduling, route of administration, and amel ... Full text Link to item Cite

Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.

Journal Article Clin Cancer Res · September 15, 2007 PURPOSE: The combination of temozolomide and irinotecan has preclinical schedule-dependent synergy against neuroblastoma but is not curative for relapsed high-risk patients. We hypothesized that the DNA repair protein methylguanine-DNA methyltransferase (M ... Full text Link to item Cite