Scholars@Duke
Lawrence Liao

Lawrence Liao

Assistant Professor of Medicine
Medicine, Cardiology
lawrence.liao@duke.edu
Duke Box 3850, Durham, NC 27710
Dept of Medicine, Durham, NC 27710

Selected Publications

Effects of Lifestyle Modification on Psychosocial Function in Patients With Resistant Hypertension: SECONDARY OUTCOMES FROM THE TRIUMPH RANDOMIZED CLINICAL TRIAL.

Journal Article J Cardiopulm Rehabil Prev · January 1, 2024 PURPOSE: In a secondary analysis of the TRIUMPH clinical trial, psychological outcomes in patients with resistant hypertension (RH) receiving a diet and exercise intervention delivered in a cardiac rehabilitation setting were compared with those receiving ... Full text Link to item Cite

Exercise and Escitalopram in the Treatment of Anxiety in Patients with Coronary Heart Disease: One Year Follow-Up of the UNWIND Randomized Clinical Trial.

Journal Article J Cardiovasc Dev Dis · September 22, 2022 Anxiety is common among patients with coronary heart disease (CHD) and is associated with a worse prognosis. UNWIND was a 12-week randomized clinical trial comparing exercise and escitalopram to placebo on measures of anxiety, depression, and CHD biomarker ... Full text Link to item Cite

Longer term benefits of exercise and escitalopram in the treatment of anxiety in patients with coronary heart disease: Six month follow-up of the UNWIND randomized clinical trial.

Journal Article Am Heart J · September 2022 BACKGROUND: Anxiety is a common comorbidity in patients with coronary heart disease (CHD) and is associated with worse prognosis. However, effective treatment for anxiety in CHD patients is uncertain. The UNWIND randomized clinical trial showed that 12-wee ... Full text Link to item Cite

Lifestyle modification and cognitive function among individuals with resistant hypertension: cognitive outcomes from the TRIUMPH trial.

Journal Article J Hypertens · July 1, 2022 BACKGROUND: Resistant hypertension is associated with increased risk of cognitive decline, stroke, and dementia. Lifestyle modification has been suggested to improve cognitive function through its salutary effects on vascular function. METHODS: Participant ... Full text Link to item Cite

Effect of Exercise, Escitalopram, or Placebo on Anxiety in Patients With Coronary Heart Disease: The Understanding the Benefits of Exercise and Escitalopram in Anxious Patients With Coronary Heart Disease (UNWIND) Randomized Clinical Trial.

Journal Article JAMA Psychiatry · November 1, 2021 IMPORTANCE: Anxiety is common among patients with coronary heart disease (CHD) and is associated with worse health outcomes; however, effective treatment for anxiety in patients with CHD is uncertain. OBJECTIVE: To determine whether exercise and escitalopr ... Full text Link to item Cite

Effects of Lifestyle Modification on Patients With Resistant Hypertension: Results of the TRIUMPH Randomized Clinical Trial.

Journal Article Circulation · October 12, 2021 BACKGROUND: Although lifestyle modifications generally are effective in lowering blood pressure (BP) among patients with unmedicated hypertension and in those treated with 1 or 2 antihypertensive agents, the value of exercise and diet for lowering BP in pa ... Full text Link to item Cite

Predicting the Development of Reduced Left Ventricular Ejection Fraction in Patients With Left Bundle Branch Block.

Journal Article Am J Cardiol · December 15, 2020 Left bundle branch block (LBBB) increases the likelihood of developing reduced left ventricular (LV) ejection fraction (EF) but predicting which patients with LBBB and normal LVEF will develop decreased LVEF remains challenging. Fifty patients with LBBB an ... Full text Link to item Cite

Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial.

Journal Article Neurology · January 15, 2019 OBJECTIVE: To determine the independent and additive effects of aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet on executive functioning in adults with cognitive impairments with no dementia (CIND) and risk factors for car ... Full text Link to item Cite

An Approach to Improve the Negative Predictive Value and Clinical Utility of Transthoracic Echocardiography in Suspected Native Valve Infective Endocarditis.

Journal Article J Am Soc Echocardiogr · April 2016 BACKGROUND: In patients with suspected native valve infective endocarditis, current guidelines recommend initial transthoracic echocardiography (TTE) followed by transesophageal echocardiography (TEE) if clinical suspicion remains. The guidelines do not ac ... Full text Link to item Cite

Assessment of Device-Related Thrombus and Associated Clinical Outcomes With the WATCHMAN Left Atrial Appendage Closure Device for Embolic Protection in Patients With Atrial Fibrillation (from the PROTECT-AF Trial).

Journal Article Am J Cardiol · April 1, 2016 Left atrial appendage closure with the WATCHMAN device is an alternative to anticoagulation for stroke prevention in selected patients with atrial fibrillation (AF). LA device-related thrombus (DRT) is poorly defined and understood. We aimed to (1) develop ... Full text Link to item Cite

Lifestyle modification for resistant hypertension: The TRIUMPH randomized clinical trial.

Journal Article Am Heart J · November 2015 BACKGROUND: Resistant hypertension (RH) is a growing health burden in this country affecting as many as 1 in 5 adults being treated for hypertension. Resistant hypertension is associated with increased risk of adverse cardiovascular disease (CVD) events an ... Full text Link to item Cite

High-risk percutaneous coronary intervention is associated with reverse left ventricular remodeling and improved outcomes in patients with coronary artery disease and reduced ejection fraction.

Journal Article Am Heart J · September 2015 BACKGROUND: Therapies that reverse pathologic left ventricular (LV) remodeling are often associated with improved outcomes. The incidence and impact of reverse LV remodeling after high-risk percutaneous coronary intervention (PCI) are unknown. METHODS: The ... Full text Link to item Cite

Echocardiographic risk stratification for early surgery with endocarditis: a cost-effectiveness analysis.

Journal Article Heart · May 2008 BACKGROUND: Despite widespread acceptance of echocardiography for diagnosis of infective endocarditis, few investigators have evaluated its utility as a risk-stratification tool to aid therapeutic decision-making. METHODS: A decision tree and Markov analys ... Full text Link to item Cite

Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes.

Journal Article Am Heart J · February 2008 BACKGROUND: Bleeding and blood transfusion are associated with increased morbidity and mortality among patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS); however, the economic consequences of these complications are not well define ... Full text Link to item Cite

Pancreatic beta-cell function as a predictor of cardiovascular outcomes and costs: findings from the Cardiovascular Health Study.

Journal Article Curr Med Res Opin · January 2008 OBJECTIVE: To explore relationships between beta-cell function and incident cardiovascular events, death, and medical costs among elderly individuals. RESEARCH DESIGN AND METHODS: In a prospective, population-based cohort of 4555 elderly individuals, we ex ... Full text Link to item Cite

Economic burden of heart failure in the elderly.

Journal Article Pharmacoeconomics · 2008 Heart failure (HF) ranks among the most costly chronic diseases in developed countries. At present these countries devote 1-2% of all healthcare expenditures towards HF. In the US, these costs are estimated at $US30.2 billion for 2007. The burden of HF is ... Full text Link to item Cite

Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study.

Journal Article Am Heart J · February 2007 BACKGROUND: Although heart failure (HF) afflicts nearly 5 million Americans, the long-term cost of HF care has not been described previously. In a prospective, longitudinal cohort of community-dwelling elderly from 4 regions, we examined the long-term cost ... Full text Link to item Cite

Financial implications of a model heart failure disease management program for providers, hospital, healthcare systems, and payer perspectives.

Journal Article Am J Cardiol · January 15, 2007 Although heart failure disease management (HFDM) programs improve patient outcomes, the implementation of these programs has been limited because of financial barriers. We undertook the present study to understand the economic incentives and disincentives ... Full text Link to item Cite

Which patients with previous bypass surgery benefit most from repeat revascularization?

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 21, 2006 Link to item Cite

Costs for heart failure with normal vs reduced ejection fraction.

Journal Article Arch Intern Med · January 9, 2006 BACKGROUND: Among the elderly population, heart failure (HF) with normal ejection fraction (EF) is more common than classic HF with low EF. However, there are few data regarding the costs of HF with normal EF. In a prospective, population-based cohort of e ... Full text Link to item Cite

Relation of early saphenous vein graft failure to outcomes following coronary artery bypass surgery.

Journal Article Am J Cardiol · November 1, 2005 Up to 20% of saphenous vein grafts (SVGs) fail within 2 years of coronary artery bypass grafting (CABG). The long-term effects of early SVG failure on major clinical events remain undefined in contemporary patient populations. We sought to examine the rela ... Full text Link to item Cite

A new anatomic score for prognosis after cardiac catheterization in patients with previous bypass surgery.

Journal Article J Am Coll Cardiol · November 1, 2005 OBJECTIVES: The purpose of this study was to determine the value of a new anatomic score for prognosis after diagnostic catheterization in patients with previous coronary artery bypass grafting (CABG). BACKGROUND: Previous CABG patients comprise a growing ... Full text Link to item Cite

Meta-analysis of survival and relief of angina pectoris after transmyocardial revascularization.

Journal Article Am J Cardiol · May 15, 2005 A meta-analysis of 7 randomized trials involving 1,053 patients was performed to evaluate the effect of transmyocardial laser revascularization as the sole procedural intervention on survival and angina relief. At 1 year, transmyocardial laser revasculariz ... Full text Link to item Cite

Meta-analysis of survival and angina relief after transmyocardial revascularization

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2005 Link to item Cite

Prediction of death and nonfatal myocardial infarction in high-risk patients: a comparison between the Duke treadmill score, peak exercise radionuclide angiography, and SPECT perfusion imaging.

Journal Article J Nucl Med · January 2005 UNLABELLED: Radionuclide exercise testing provides prognostic information in patients with known or suspected coronary artery disease (CAD). The relative contribution of 3 noninvasive tests--the Duke treadmill score (DTS), first-pass radionuclide angiograp ... Link to item Cite

Usefulness of myocardial viability or ischemia in predicting long-term survival for patients with severe left ventricular dysfunction undergoing revascularization.

Journal Article Am J Cardiol · May 15, 2004 In 107 patients with coronary disease and severe left ventricular dysfunction, we examined the prognostic power of viability identified by dobutamine stress echocardiography. At a mean follow-up of 27 months, patients with viable myocardium who underwent r ... Full text Link to item Cite

Differences in care-seeking behavior for acute chest pain in the United States and Japan.

Journal Article Am Heart J · April 2004 BACKGROUND: Delay from onset of acute myocardial infarction symptoms to the delivery of medical care is a major determinant of prognosis. Although studies have explored patient factors for delay in seeking care, there are limited data on international diff ... Full text Link to item Cite

Clinical prediction models: are we building better mousetraps?

Journal Article J Am Coll Cardiol · September 3, 2003 Full text Link to item Cite

Economic burden of nonischemic congestive heart failure: Evidence from PRAISE-2

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 19, 2003 Link to item Cite

Use of the peak troponin value to differentiate myocardial infarction from reversible neurogenic left ventricular dysfunction associated with aneurysmal subarachnoid hemorrhage.

Journal Article J Neurosurg · March 2003 OBJECT: Differentiating myocardial infarction (MI) from reversible neurogenic left ventricular dysfunction (stunned myocardium [SM]) associated with aneurysmal subarachnoid hemorrhage (SAH) is critical for early surgical intervention. The authors hypothesi ... Full text Link to item Cite

Impact of an interactive video on decision making of patients with ischemic heart disease.

Journal Article J Gen Intern Med · June 1996 An experimental pilot study using repeated measures to examine the impact of an interactive video program on the decision making of patients with ischemic heart disease was carried on at a tertiary care center and a Veterans Affairs hospital. The patients ... Full text Link to item Cite