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Predicting the Development of Reduced Left Ventricular Ejection Fraction in Patients With Left Bundle Branch Block.

Publication ,  Journal Article
Atwater, BD; Emerek, K; Samad, Z; Sze, E; Black-Maier, E; Loring, Z; Ugander, M; Liao, L; Kisslo, J; Søgaard, P; Friedman, DJ
Published in: Am J Cardiol
December 15, 2020

Left bundle branch block (LBBB) increases the likelihood of developing reduced left ventricular (LV) ejection fraction (EF) but predicting which patients with LBBB and normal LVEF will develop decreased LVEF remains challenging. Fifty patients with LBBB and normal LVEF were retrospectively identified. Clinical, electrocardiographic, and echocardiographic variables were compared between patients who developed a decreased LVEF and those who did not. A total of 16 of 50 patients developed reduced LVEF after 4.3 (SD = 2.8) years of follow-up. Baseline patient and electrocardiographic variables were similar between patients who did and did not develop decreased LVEF. Baseline LVEF was lower in patients who developed decreased LVEF than in those who did not (51.9% [SD = 2.2%] vs 54.9% [SD = 4.4%], p <0.01). Diastolic filling time (DFT) accounted for a significantly smaller percentage of the cardiac cycle in patients who developed decreased LVEF than in those who did not (35.9%, [SD = 6.9%] vs 44.4% [SD = 4.5%] p <0.01). In univariable logistic regression, DFT had a C-statistic of 0.86 (p <0.0001) for prediction of development of decreased LVEF. In conclusion, patients in whom DFT accounted for <38% of the cardiac cycle had a relative risk of developing decreased LVEF of 7.0 (95% confidence interval 3.0 to 16.0) compared to patients with DFT accounting for ≥38% of the cardiac cycle.

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Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

December 15, 2020

Volume

137

Start / End Page

39 / 44

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Retrospective Studies
  • Male
  • Humans
  • Female
  • Electrocardiography
  • Echocardiography
  • Disease Progression
 

Citation

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Atwater, B. D., Emerek, K., Samad, Z., Sze, E., Black-Maier, E., Loring, Z., … Friedman, D. J. (2020). Predicting the Development of Reduced Left Ventricular Ejection Fraction in Patients With Left Bundle Branch Block. Am J Cardiol, 137, 39–44. https://doi.org/10.1016/j.amjcard.2020.09.034
Atwater, Brett D., Kasper Emerek, Zainab Samad, Edward Sze, Eric Black-Maier, Zak Loring, Martin Ugander, et al. “Predicting the Development of Reduced Left Ventricular Ejection Fraction in Patients With Left Bundle Branch Block.Am J Cardiol 137 (December 15, 2020): 39–44. https://doi.org/10.1016/j.amjcard.2020.09.034.
Atwater BD, Emerek K, Samad Z, Sze E, Black-Maier E, Loring Z, et al. Predicting the Development of Reduced Left Ventricular Ejection Fraction in Patients With Left Bundle Branch Block. Am J Cardiol. 2020 Dec 15;137:39–44.
Atwater, Brett D., et al. “Predicting the Development of Reduced Left Ventricular Ejection Fraction in Patients With Left Bundle Branch Block.Am J Cardiol, vol. 137, Dec. 2020, pp. 39–44. Pubmed, doi:10.1016/j.amjcard.2020.09.034.
Atwater BD, Emerek K, Samad Z, Sze E, Black-Maier E, Loring Z, Ugander M, Liao L, Kisslo J, Søgaard P, Friedman DJ. Predicting the Development of Reduced Left Ventricular Ejection Fraction in Patients With Left Bundle Branch Block. Am J Cardiol. 2020 Dec 15;137:39–44.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

December 15, 2020

Volume

137

Start / End Page

39 / 44

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Retrospective Studies
  • Male
  • Humans
  • Female
  • Electrocardiography
  • Echocardiography
  • Disease Progression