Scholars@Duke
Lijing Yan

Lijing Yan

Professor of Global Health at Duke Kunshan University
DKU Faculty

Selected Publications

Secondary Analysis of the Salt Substitute and Stroke Study (SSaSS): Effects of Potassium-Enriched Salt on Cardiac Outcomes.

Journal Article Hypertension (Dallas, Tex. : 1979) · May 2024 BackgroundThe SSaSS (Salt Substitute and Stroke Study) has shown that use of a potassium-enriched salt lowers the risk of stroke, total cardiovascular events, and premature death. The effects on cause-specific cardiac outcomes are reported here. Full text Cite

Evaluating the accuracy of the Ophthalmologist Robot for multiple blindness-causing eye diseases: a multicentre, prospective study protocol.

Journal Article BMJ open · March 2024 IntroductionEarly eye screening and treatment can reduce the incidence of blindness by detecting and addressing eye diseases at an early stage. The Ophthalmologist Robot is an automated device that can simultaneously capture ocular surface and fun ... Full text Cite

The developmental origins of health and disease and intergenerational inheritance: a scoping review of multigenerational cohort studies.

Journal Article Journal of developmental origins of health and disease · March 2024 Epidemiologic research has increasingly acknowledged the importance of developmental origins of health and disease (DOHaD) and suggests that prior exposures can be transferred across generations. Multigenerational cohorts are crucial to verify the intergen ... Full text Cite

Individual perceptions of community efficacy for non-communicable disease management in twelve communities in China: cross-sectional and longitudinal analyses.

Journal Article Public Health · January 2024 OBJECTIVES: This objective of this study was to use empirical data to assess cross-sectional variation singular and changes over time in community efficacy for non-communicable diseases (NCDs) management (COEN) and to examine individual factors associated ... Full text Link to item Cite

Trends in Health Service Use for Dry Eye Disease From 2017 to 2021: A Real-World Analysis of 369,755 Outpatient Visits.

Journal Article Translational vision science & technology · January 2024 PurposeWe aimed to analyze the trends and patterns in outpatient health service treatment of dry eye disease (DED) using real-world data from Yinzhou District in China.MethodsThe Yinzhou Health Information System is a comprehensive databa ... Full text Cite

World Heart Federation Roadmap for Secondary Prevention of Cardiovascular Disease: 2023 Update.

Journal Article Global heart · January 2024 BackgroundSecondary prevention lifestyle and pharmacological treatment of atherosclerotic cardiovascular disease (ASCVD) reduce a high proportion of recurrent events and mortality. However, significant gaps exist between guideline recommendations ... Full text Cite

Residential proximity to major roadways and hearing impairment in Chinese older adults: a population-based study.

Journal Article BMC public health · December 2023 BackgroundWith rapid urban sprawl, growing people are living in the vicinity of major roadways. However, little is known about the relationship between residential proximity to major roadways and hearing impairment (HI).MethodsWe derived ... Full text Cite

Association between individual resilience and depression or anxiety among general adult population during COVID-19: a systematic review.

Journal Article Journal of public health (Oxford, England) · November 2023 BackgroundThe coronavirus disease (COVID-19) pandemic exacerbated depression and anxiety worldwide. Resilience is important to maintain mental health during uncertain times, but limited study has systematically reviewed its association with depres ... Full text Cite

Intake of sugary beverages with chronic conditions and multimorbidity: a prospective cohort study of UK Biobank.

Journal Article International journal of epidemiology · October 2023 BackgroundThe burden of chronic conditions associated with sugary beverages is increasing but little is known about the role of different types of sugary beverages in the co-occurrence of multiple chronic conditions ('multimorbidity'). To inform f ... Full text Cite

Changes in physical activity and all-cause mortality in the oldest old population: Findings from the Chinese Longitudinal Healthy Longevity Survey (CLHLS).

Journal Article Preventive medicine · October 2023 BackgroundInsufficient or decreasing physical activity is common in older adults. Most studies on physical activity changes and mortality were conducted in adults younger than 80 years old in developed countries. We aimed to investigate the relati ... Full text Cite

Stroke and activity limitation in Chinese adults 65 Years or older.

Journal Article Disabil Health J · July 2023 BACKGROUND: Differences in activity limitations between stroke survivors and people with other chronic conditions and how their levels of activity limitation vary by sociodemographic characteristics have not been well quantified. OBJECTIVE: To quantify act ... Full text Link to item Cite

Evaluating the effectiveness and cost-effectiveness of free influenza vaccination policy for older adults in Yinzhou, China: Study protocol of a real-world analyses.

Journal Article Vaccine · July 2023 BackgroundInfluenza causes excessive morbidity and mortality among older adults. While influenza vaccine provides protection against its infection, the vaccination coverage in China among older adults has been very low. Previous evidence on the co ... Full text Cite

Effectiveness of eHealth Smoking Cessation Interventions: Systematic Review and Meta-Analysis.

Journal Article Journal of medical Internet research · July 2023 BackgroundRapid advancements in eHealth and mobile health (mHealth) technologies have driven researchers to design and evaluate numerous technology-based interventions to promote smoking cessation. The evolving nature of cessation interventions em ... Full text Cite

Interventions and management on multimorbidity: An overview of systematic reviews.

Journal Article Ageing research reviews · June 2023 BackgroundMultimorbidity poses an immense burden on the healthcare systems globally, whereas the management strategies and guidelines for multimorbidity are poorly established. We aim to synthesize current evidence on interventions and management ... Full text Cite

Environmental greenspace, subjective well-being, and all-cause mortality in elderly Chinese: Association and mediation study in a prospective cohort.

Journal Article Environmental research · June 2023 BackgroundSubjective well-being (SWB) measures mental health and happiness. Greenspace can have a positive impact on mental health, and higher SWB is associated with lower all-cause mortality. We conducted a mediation analysis on greenspace and al ... Full text Cite

Trends in global health research among universities in China: a bibliometric analysis.

Journal Article Glob Health Res Policy · April 6, 2023 BACKGROUND: There has been considerable progress in developing global health education and research in China. Nevertheless, evidence of the progress of Chinese universities' contributions to global health research is limited. More efforts are needed to dep ... Full text Link to item Cite

Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study.

Journal Article Journal of the American Heart Association · March 2023 Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI. Methods and Results Dat ... Full text Cite

Improving cardiovascular health in rural China and beyond.

Journal Article Lancet (London, England) · March 2023 Full text Cite

Digital health interventions for non-communicable disease management in primary health care in low-and middle-income countries.

Journal Article NPJ Digit Med · February 1, 2023 Current evidence on digital health interventions is disproportionately concerned with high-income countries and hospital settings. This scoping review evaluates the extent of use and effectiveness of digital health interventions for non-communicable diseas ... Full text Link to item Cite

Family support and medication adherence among residents with hypertension in informal settlements of Nairobi, Kenya: a mixed-method study.

Journal Article J Hum Hypertens · January 2023 Suboptimal medication adherence is a major barrier to hypertension control in Kenya, especially among informal urban settlement areas (sometimes referred to as "slums"). The few studies that have specifically explored medication adherence among this popula ... Full text Link to item Cite

An economic evaluation of a primary care-based technology-enabled intervention for stroke secondary prevention and management in rural China: a study protocol.

Journal Article Front Neurol · 2023 INTRODUCTION: Secondary prevention of stroke is a leading challenge globally and only a few strategies have been tested to be effective in supporting stroke survivors. The system-integrated and technology-enabled model of care (SINEMA) intervention, a prim ... Full text Link to item Cite

Community Efficacy for Non-Communicable Disease Management and Medication Adherence: The Sequential Mediating Role of Self-Efficacy and Depressive Symptoms.

Journal Article Patient Prefer Adherence · 2023 PURPOSE: We assess whether the sequential mediating effects of self-efficacy and depressive symptoms on the relationship between community efficacy for non-communicable disease management (COEN) and medication adherence and whether these relationships diff ... Full text Link to item Cite

Health Professionals' Perceptions of Disparities in Hypertension Control: A Mixed Methods Study.

Journal Article American journal of hypertension · November 2022 BackgroundHealth professionals' commitment is needed to address disparities in hypertension control by ancestry, but their perceptions regarding these disparities are understudied.MethodsCross-sectional mixed methods study in a universal ... Full text Cite

Aldehyde dehydrogenase 2 rs671 polymorphism and multiple diseases: protocol for a quantitative umbrella review of meta-analyses.

Journal Article Syst Rev · September 2, 2022 BACKGROUND: The mutant allele (*2) of aldehyde dehydrogenase type 2 (ALDH2) caused by a single nucleotide variant (rs671) inhibits enzymatic activity and is associated with multiple diseases. In recent years, an explosive number of original studies and met ... Full text Link to item Cite

Promoting the adoption of local governmental policy on the reimbursement of chronic disease medicines (PAPMed): study protocol of a field-based cluster randomized trial in rural Nantong, China.

Journal Article Trials · September 2022 BackgroundAmong rural Chinese patients with non-communicable diseases (NCDs), low socioeconomic status increases the risk of developing NCDs and associated financial burdens in paying for medicines and treatments. Despite the chronic disease medic ... Full text Cite

Comparing Effects of FOXO3 and Residing in Urban Areas on Longevity: A Gene-Environment Interaction Study.

Journal Article J Gerontol A Biol Sci Med Sci · August 12, 2022 Forkhead box O3 (FOXO3) is a candidate longevity gene. Urban residents are also positively associated with longer life expectancy. We conducted a gene-environment interaction to assess the synergistic effect of FOXO3 and urban/rural environments on mortali ... Full text Link to item Cite

Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-Year Prospective Longitudinal Cohort Study.

Journal Article J Gerontol A Biol Sci Med Sci · August 12, 2022 SIRT1 and FOXO3 are both associated with longevity. Molecular biology research in many organisms (yeast, nematode worm Caenorhabditis elegans, and mice mammalian models) shows SIRT1 acts on the FOXO family of forkhead transcription factors to respond to ox ... Full text Link to item Cite

Effect of FOXO3 and Air Pollution on Cognitive Function: A Longitudinal Cohort Study of Older Adults in China From 2000 to 2014.

Journal Article J Gerontol A Biol Sci Med Sci · August 12, 2022 Forkhead Box O 3 (FOXO3) genotype is strongly associated with human longevity and may be protective against neurodegeneration. Air pollution is a risk factor for cognitive decline and dementia. We aimed to study the individual and combined effects of FOXO3 ... Full text Link to item Cite

The association between self-rated health and all-cause mortality and explanatory factors in China's oldest-old population.

Journal Article Journal of global health · July 2022 BackgroundSelf-rated health (SRH) is considered a condensed summary of information about bodily conditions that involves people's biological, cognitive, and cultural status, but has been under-studied in the oldest old population. This study aimed ... Full text Cite

Healthy eating and all-cause mortality among Chinese aged 80 years or older.

Journal Article Int J Behav Nutr Phys Act · May 26, 2022 BACKGROUND: There is little evidence of the influence of dietary patterns on mortality risk among adults 80 years or older ("oldest-old"). We evaluated the association between the Simplified Healthy Eating index (SHE-index) and mortality among Chinese olde ... Full text Link to item Cite

Impact of the COVID-19 Pandemic on Chronic Disease Care in India, China, Hong Kong, Korea, and Vietnam.

Journal Article Asia Pac J Public Health · May 2022 This study aims to provide evidence on how the COVID-19 pandemic has impacted chronic disease care in diverse settings across Asia. Cross-sectional surveys were conducted to assess the health, social, and economic consequences of the pandemic in India, Chi ... Full text Link to item Cite

Cost-Effectiveness of a Household Salt Substitution Intervention: Findings From 20 995 Participants of the Salt Substitute and Stroke Study.

Journal Article Circulation · May 2022 BackgroundSSaSS (Salt Substitute and Stroke Study), a 5-year cluster randomized controlled trial, demonstrated that replacing regular salt with a reduced-sodium, added-potassium salt substitute reduced the risks of stroke, major adverse cardiovasc ... Full text Cite

Air pollution, residential greenness, and metabolic dysfunction biomarkers: analyses in the Chinese Longitudinal Healthy Longevity Survey.

Journal Article BMC public health · May 2022 BackgroundWe hypothesize higher air pollution and fewer greenness exposures jointly contribute to metabolic syndrome (MetS), as mechanisms on cardiometabolic mortality.MethodsWe studied the samples in the Chinese Longitudinal Healthy Long ... Full text Cite

Economic hardships from COVID-19 and its association with socioeconomic factors and diabetes management indicators: A cross-sectional study.

Journal Article Heliyon · May 2022 AIMS: The three objectives of this study were to determine the economic hardships of COVID-19 pandemic, their socio-economic predictors, and their association with diabetes management indicators in three cities in a middle-income country. METHODS: A commun ... Full text Link to item Cite

An mHealth Intervention to Improve Medication Adherence and Health Outcomes Among Patients With Coronary Heart Disease: Randomized Controlled Trial.

Journal Article Journal of medical Internet research · March 2022 BackgroundThe treatment of many chronic illnesses involves long-term pharmaceutical therapy, but it is an ongoing challenge to find effective ways to improve medication adherence to promote good health outcomes. Cardioprotective medications can pr ... Full text Cite

Hypertension in China: burdens, guidelines and policy responses: a state-of-the-art review.

Journal Article Journal of human hypertension · February 2022 Hypertension is a leading risk factor of cardiovascular disease and it is becoming increasingly prevalent globally. Correspondingly, the Chinese government and public health institutions have issued a series of policy documents and guidelines for hypertens ... Full text Cite

Health Services Use and Expenditures among Middle-Aged and Elderly Residents with Hypertension Comorbidity: A Longitudinal Study in Jiangsu Province, China

Journal Article Chinese Economy · January 1, 2022 Hypertension is the most prevalent chronic condition in China and is associated with an increased risk of comorbidity. This study aims to investigate health services use and expenditures among community-dwelling residents with hypertension comorbidity. Dat ... Full text Cite

Strengthening urban primary healthcare service delivery using electronic health technologies: A qualitative study in urban Nepal.

Journal Article Digital health · January 2022 BackgroundNepal is a South Asian country with a high burden of non-communicable diseases. Electronic health technologies are a promising strategy to mitigate the rising burden of non-communicable diseases by strengthening primary healthcare center ... Full text Cite

Mediation analysis of leisure activities on the association between cognitive function and mortality: a longitudinal study of 42,942 Chinese adults 65 years and older.

Journal Article Epidemiology and health · January 2022 ObjectivesPrevious studies have established associations of cognitive function and leisure activities with mortality. This study aimed to evaluate whether leisure activities causally mediate these associations.MethodsThis longitudinal stu ... Full text Cite

Factors Associated With the Use of a Salt Substitute in Rural China.

Journal Article JAMA network open · December 2021 ImportanceLowering sodium intake reduces blood pressure and may reduce the risk of cardiovascular diseases. The use of reduced-sodium salt (a salt substitute) may achieve sodium reduction, but its effectiveness may be associated with the context o ... Full text Cite

Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older.

Journal Article Brain and behavior · October 2021 ObjectivesThe oldest-old (aged ≥80 years) are the fastest growing population segment and age is related to cognitive impairment. We aimed to estimate the association between cognitive impairment and all-cause mortality, in addition to the relation ... Full text Cite

Effect of Salt Substitution on Cardiovascular Events and Death.

Journal Article The New England journal of medicine · September 2021 BackgroundSalt substitutes with reduced sodium levels and increased potassium levels have been shown to lower blood pressure, but their effects on cardiovascular and safety outcomes are uncertain.MethodsWe conducted an open-label, cluster ... Full text Cite

Association between allostatic load and mortality among Chinese older adults: the Chinese Longitudinal Health and Longevity Study.

Journal Article BMJ open · August 2021 BackgroundAllostatic load (AL) has shown that high burden of AL is associated with increased risk of adverse outcomes, but little attention has been paid to China with largest ageing population in the world.ObjectiveThis study is to exami ... Full text Cite

Health system gaps in cardiovascular disease prevention and management in Nepal.

Journal Article BMC health services research · July 2021 BackgroundCardiovascular diseases (CVDs) are the leading cause of deaths and disability in Nepal. Health systems can improve CVD health outcomes even in resource-limited settings by directing efforts to meet critical system gaps. This study aimed ... Full text Cite

Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study.

Journal Article PLoS Med · June 2021 BACKGROUND: Apolipoprotein E (APOE) ε4 is the single most important genetic risk factor for cognitive impairment and Alzheimer disease (AD), while lifestyle factors such as smoking, drinking, diet, and physical activity also have impact on cognition. The g ... Full text Link to item Cite

Disciplinary development of global health academic degree programs in China

Journal Article Global Health Journal · June 1, 2021 This study aims to provide a brief overview of the history and development of global health education (GHE) as academic degree programs worldwide, and to identify GHE's development opportunities and obstacles in China. This is a state-of-the-art review of ... Full text Cite

Excess mortality among patients with severe mental disorders and effects of community-based mental healthcare: a community-based prospective study in Sichuan, China.

Journal Article BJPsych open · April 2021 BackgroundHigh-quality primary care reduces premature mortality in the general population, but evidence for psychiatric patients in China is scarce.AimsTo confirm excess mortality in patients with severe mental illness (SMI), and to exami ... Full text Cite

Effectiveness of a primary care-based integrated mobile health intervention for stroke management in rural China (SINEMA): A cluster-randomized controlled trial.

Journal Article PLoS Med · April 2021 BACKGROUND: Managing noncommunicable diseases through primary healthcare has been identified as the key strategy to achieve universal health coverage but is challenging in most low- and middle-income countries. Stroke is the leading cause of death and disa ... Full text Link to item Cite

A Mixed Methods Process Evaluation of a Clustered-Randomized Controlled Trial to Determine the Effects of Community-Based Dietary Sodium Reduction in Rural China.

Journal Article Frontiers in medicine · January 2021 Purpose: A clustered-randomized controlled trial was conducted to determine the effects of a sodium reduction program in 120 rural villages in Northern China. This mixed-methods process evaluation was used to investigate the implementation and to ev ... Full text Cite

Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analysis in China.

Journal Article Front Med (Lausanne) · 2021 Introduction: The interactions between apolipoprotein E (APOE) genotype and diet pattern changes were found significant in several trials, implying that APOE gene may modify the effect of animal protein-rich food on health outcomes. We aim to study the int ... Full text Link to item Cite

Perception and Use of Primary Healthcare Services Among People With Cardiometabolic Diseases in Two Resource-Limited Areas in Nepal: A Mixed Methods Study.

Journal Article Front Public Health · 2021 Nepal is a country in south Asia with a high burden of cardiometabolic diseases (CMDs). Strengthening primary healthcare (PHC) is a key strategy to mitigate this increasing burden and achieve universal health coverage. While previous studies in Nepal have ... Full text Link to item Cite

World Heart Federation Roadmap for Hypertension - A 2021 Update.

Journal Article Global heart · January 2021 The World Heart Federation (WHF) Roadmap series covers a large range of cardiovascular conditions. These Roadmaps identify potential roadblocks and their solutions to improve the prevention, detection and management of cardiovascular diseases and provide a ... Full text Cite

The Implementation of a Primary Care-Based Integrated Mobile Health Intervention for Stroke Management in Rural China: Mixed-Methods Process Evaluation.

Journal Article Front Public Health · 2021 Background: There is a lack of evidence concerning the effective implementation of strategies for stroke prevention and management, particularly in resource-limited settings. A primary-care-based integrated mobile health intervention (SINEMA intervention) ... Full text Link to item Cite

Feasibility and validity of using death surveillance data and SmartVA for fact and cause of death in clinical trials in rural China: a substudy of the China salt substitute and stroke study (SSaSS).

Journal Article Journal of epidemiology and community health · December 2020 BackgroundIn rural China, mortality surveillance data may be an alternative to primary data collection in clinical trials; SmartVA (verbal autopsy) is also a potential alternative for endpoint adjudication. The feasibility and validity of both nee ... Full text Cite

Hypertension Care Coordination and Feasibility of Involving Female Community Health Volunteers in Hypertension Management in Kavre District, Nepal: A Qualitative Study.

Journal Article Glob Heart · October 23, 2020 BACKGROUND: Hypertension and related complications are major contributors to morbidity and mortality in Nepal. Community health workers have been proposed as promising health cadres to meet the growing healthcare demand for non-communicable disease managem ... Full text Link to item Cite

Serum 25-Hydroxyvitamin D, Albumin, and Mortality Among Chinese Older Adults: A Population-based Longitudinal Study.

Journal Article J Clin Endocrinol Metab · August 1, 2020 CONTEXT: The associations between serum 25-hydroxyvitamin D concentrations [25(OH)D] and all-cause mortality have been inconsistent in existing literatures. One plausible reason is the interaction of intrinsic vitamin D with other biological conditions suc ... Full text Link to item Cite

Quality, Functionality, and Features of Chinese Mobile Apps for Diabetes Self-Management: Systematic Search and Evaluation of Mobile Apps.

Journal Article JMIR mHealth and uHealth · April 2020 BackgroundThe emergence and advancement of mobile technologies offer a promising opportunity for people with diabetes to improve their self-management. Despite the proliferation of mobile apps, few studies have evaluated the apps that are availabl ... Full text Cite

Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS).

Journal Article American heart journal · March 2020 The Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individu ... Full text Cite

Evaluating the Feasibility and Acceptability of a Mobile Health-Based Female Community Health Volunteer Program for Hypertension Control in Rural Nepal: Cross-Sectional Study.

Journal Article JMIR mHealth and uHealth · March 2020 BackgroundHypertension is a major modifiable risk factor for cardiovascular disease, the world's leading cause of death. The prevalence of hypertension is disproportionately higher in South Asian countries than in other regions of the world. Scree ... Full text Cite

System-integrated technology-enabled model of care (SINEMA) to improve the health of stroke patients in rural China: Statistical analysis plan for a cluster-randomized controlled trial.

Journal Article Int J Stroke · February 2020 BACKGROUND: The system-integrated technology-enabled model of care (SINEMA) trial aimed to evaluate the effectiveness of a community-based multi-component intervention for secondary prevention of stroke in rural China. OBJECTIVE: To present the detailed st ... Full text Link to item Cite

Women's Participation in Cardiovascular Clinical Trials From 2010 to 2017.

Journal Article Circulation · February 2020 BackgroundCardiovascular disease is the leading cause of death among women worldwide, yet, women have historically been underrepresented in cardiovascular trials.MethodsWe systematically assessed the participation of women in completed ca ... Full text Cite

A Novel Dried Blood Spot Detection Strategy for Characterizing Cardiovascular Diseases.

Journal Article Frontiers in cardiovascular medicine · January 2020 Cardiovascular diseases (CVDs) are the leading cause of death in China. Conventional diagnostic methods are dependent on advanced instruments, which are expensive, inaccessible, and inconvenient in underdeveloped areas. To build a novel dried blood spot (D ... Full text Cite

Development and Local Contextualization of Mobile Health Messages for Enhancing Disease Management Among Community-Dwelling Stroke Patients in Rural China: Multimethod Study.

Journal Article JMIR mHealth and uHealth · December 17, 2019 BACKGROUND:Rural China has experienced an increasing health burden because of stroke. Stroke patients in rural communities have relatively poor awareness of and adherence to evidence-based secondary prevention and self-management of stroke. Mobile technolo ... Full text Cite

Inequity in healthcare needs, health service use and financial burden of medical expenditures in China: results from a consecutive household monitoring study in Jiangsu Province.

Journal Article BMC Health Serv Res · December 16, 2019 BACKGROUND: Although public medical insurance covers over 95% of the population in China, disparities in health service use and out-of-pocket (OOP) health expenditure across income groups are still widely observed. This study aims to investigate the socio- ... Full text Link to item Cite

Residential greenness, activities of daily living, and instrumental activities of daily living: A longitudinal cohort study of older adults in China.

Journal Article Environmental epidemiology (Philadelphia, Pa.) · October 2019 We aimed to explore whether higher levels of residential greenness were related to lower odds of disabilities in activities of daily living (ADL) and instrumental activities of daily living (IADL).MethodsWe included older adults 65 years of age or ... Full text Cite

Home Blood Pressure Monitoring by a Mobile-Based Model in Chongqing, China: A Feasibility Study.

Journal Article International journal of environmental research and public health · September 2019 Purpose: Increasing attention is being paid to the role of the intelligent self-management of hypertension under the context of increasing prevalence but limited medical resources. However, heterogeneity in interventions and outcome measures has hin ... Full text Cite

Dietary Sodium Reduction Reduces Albuminuria: A Cluster Randomized Trial.

Journal Article Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · July 2019 ObjectivesThe objective of the study was to assess the impact of sustained dietary salt reduction on albuminuria in nearly 2000 community-dwelling adults.Design and methodsThe present study is a prespecified secondary analysis of the Chin ... Full text Cite

Caregiver-Delivered Stroke Rehabilitation in Rural China.

Journal Article Stroke · July 2019 Background and Purpose- Stroke disability is a major health burden in rural China where rehabilitation services are inadequate. We aimed to determine the effectiveness of a novel nurse-led, caregiver-delivered model of stroke rehabilitation in rural China. ... Full text Link to item Cite

A Smart and Multifaceted Mobile Health System for Delivering Evidence-Based Secondary Prevention of Stroke in Rural China: Design, Development, and Feasibility Study.

Journal Article JMIR mHealth and uHealth · July 2019 BackgroundMobile health (mHealth) technologies hold great promise in improving the delivery of high-quality health care services. Yet, there has been little research so far applying mHealth technologies in the context of delivering stroke care in ... Full text Cite

System-integrated technology-enabled model of care to improve the health of stroke patients in rural China: protocol for SINEMA-a cluster-randomized controlled trial.

Journal Article Am Heart J · January 2019 BACKGROUND: Despite the significant burden of stroke in rural China, secondary prevention of stroke is suboptimal. This study aims to develop a SINEMA for the secondary prevention of stroke in rural China and to evaluate the effectiveness of the model comp ... Full text Link to item Cite

Academia-industry digital health collaborations: A cross-cultural analysis of barriers and facilitators.

Journal Article Digit Health · 2019 BACKGROUND: Development and uptake of digital health technologies benefit from cross-sectoral efforts from academia and industry. Our study aims to identify the barriers and facilitators associated with academia-industry collaborations in digital health in ... Full text Link to item Cite

Feasibility assessment of invigorating grassrooTs primary healthcare for prevention and management of cardiometabolic diseases in resource-limited settings in China, Kenya, Nepal, Vietnam (the FAITH study): rationale and design.

Journal Article Glob Health Res Policy · 2019 BACKGROUND: Cardiometabolic diseases are the leading cause of death and disability in many low- and middle-income countries. As the already severe burden from these conditions continues to increase in low- and middle-income countries, cardiometabolic disea ... Full text Open Access Link to item Cite

Effectiveness of mHealth Interventions in Improving Medication Adherence Among People with Hypertension: a Systematic Review.

Journal Article Current hypertension reports · August 2018 Purpose of reviewThis study aims to systematically review existing evidence on the effectiveness of mobile health technology (mHealth) interventions in addressing medication adherence among people with hypertension.Recent findingsTwenty-o ... Full text Cite

Policy environment for prevention, control and management of cardiovascular diseases in primary health care in Kenya.

Journal Article BMC health services research · May 2018 BackgroundIn Kenya, cardiovascular diseases (CVDs) accounted for more than 10% of total deaths and 4% of total Disability-Adjusted Life Years (DALYs) in 2015 with a steady increase over the past decade. The main objective of this paper was to revi ... Full text Cite

A qualitative evaluation of a simplified cardiovascular management program in Tibet, China.

Journal Article Globalization and health · March 2018 BackgroundThe simplified cardiovascular management (SimCard Study) program was a cluster randomized controlled trial conducted in Tibet, China to evaluate a multifaceted intervention consisting of appropriate medication prescriptions and lifestyle ... Full text Cite

Using Mobile Health Intervention to Improve Secondary Prevention of Coronary Heart Diseases in China: Mixed-Methods Feasibility Study.

Journal Article JMIR mHealth and uHealth · January 2018 BackgroundCoronary heart disease (CHD) is the leading cause of cardiovascular mortality worldwide, yet implementation of evidence-based strategies for secondary prevention remains suboptimal.ObjectiveThis study aimed to evaluate the feasi ... Full text Cite

Telmisartan and hydrochlorothiazide antihypertensive treatment in high sodium intake population: a randomized double-blind trial.

Journal Article Journal of hypertension · October 2017 ObjectivesTo compare the blood pressure (BP)-lowering effects of telmisartan 40 mg/day and hydrochlorothiazide (HCTZ) 25 mg/day in high sodium intake patients with mild-to-moderate hypertension in China.MethodsIn this randomized, double-b ... Full text Cite

Rationale, design, and baseline characteristics of the Salt Substitute and Stroke Study (SSaSS)-A large-scale cluster randomized controlled trial.

Journal Article American heart journal · June 2017 Lowering sodium intake with a reduced-sodium, added potassium salt substitute has been proved to lower blood pressure levels. Whether the same strategy will also reduce the risks of vascular outcomes is uncertain and controversial. The SSaSS has been desig ... Full text Cite

Addressing post-stroke care in rural areas with Peru as a case study. Placing emphasis on evidence-based pragmatism.

Journal Article Journal of the neurological sciences · April 2017 Stroke is a major cause of death and disability, with most of its burden now affecting low- and middle-income countries (LMIC). People in rural areas of LMIC who have a stroke receive very little acute stroke care and local healthcare workers and family ca ... Full text Cite

Effect of Mobile Health Interventions on the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis.

Journal Article The Canadian journal of cardiology · February 2017 BackgroundDespite the strong uptake of mobile health (mhealth) technology targeted at cardiovascular care, it is still unclear if this improves adherence to therapy and patient-related outcomes in those with established cardiovascular disease. ... Full text Cite

Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015.

Journal Article JAMA · January 10, 2017 IMPORTANCE: Elevated systolic blood (SBP) pressure is a leading global health risk. Quantifying the levels of SBP is important to guide prevention policies and interventions. OBJECTIVE: To estimate the association between SBP of at least 110 to 115 mm Hg a ... Full text Link to item Cite

Salt reduction in China: a state-of-the-art review.

Journal Article Risk management and healthcare policy · January 2017 ObjectiveThis study aimed to reveal the latest evidence on salt reduction initiatives in China in order to identify the contextual cost-effective interventions, as well as the barriers encountered during China's long march to reach its population ... Full text Cite

Cost and cost-effectiveness of a school-based education program to reduce salt intake in children and their families in China.

Journal Article PloS one · January 2017 ObjectiveThe School-based Education Program to Reduce Salt Intake in Children and Their Families study was a cluster randomized control trial among grade five students in 28 primary schools and their families in Changzhi, China. It achieved a sign ... Full text Cite

China's Multisectoral Approach to Chronic Disease.

Journal Article Global heart · December 2016 Full text Cite

A randomized controlled trial on rehabilitation through caregiver-delivered nurse-organized service programs for disabled stroke patients in rural china (the RECOVER trial): design and rationale.

Journal Article Int J Stroke · October 2016 RATIONALE: Stroke is the leading cause of death and disability in rural China. For stroke patients residing in resource-limited rural areas, secondary prevention and rehabilitation are largely unavailable, and where present, are far below evidence-based st ... Full text Link to item Cite

Use of Smartphone for Verbal Autopsy.

Journal Article Asia-Pacific journal of public health · October 2016 Traditionally, verbal autopsies (VA) are collected on paper-based questionnaires and reviewed by physicians for cause of death assignment, it is resource intensive and time consuming. The Population Health Metrics Research Consortium VA questionnaires was ... Full text Cite

Development of a mobile phone-based intervention to improve adherence to secondary prevention of coronary heart disease in China.

Journal Article Journal of medical engineering & technology · October 2016 Coronary heart disease (CHD) is a major disease burden globally and in China, but secondary prevention among CHD patients remains insufficient. Mobile health (mHealth) technology holds promise for improving secondary prevention but few previous studies inc ... Full text Cite

Random Plasma Glucose Levels and Cardiovascular Risk.

Journal Article JAMA cardiology · October 2016 Full text Cite

Towards sustainable partnerships in global health: the case of the CRONICAS Centre of Excellence in Chronic Diseases in Peru.

Journal Article Globalization and health · June 2016 Human capital requires opportunities to develop and capacity to overcome challenges, together with an enabling environment that fosters critical and disruptive innovation. Exploring such features is necessary to establish the foundation of solid long-term ... Full text Cite

Salt sales survey: a simplified, cost-effective method to evaluate population salt reduction programs--a cluster-randomized trial.

Journal Article Hypertension research : official journal of the Japanese Society of Hypertension · April 2016 Twenty-four-hour urine collection, as a gold standard method of measuring salt intake, is costly and resource consuming, which limits its use in monitoring population salt reduction programs. Our study aimed to determine whether a salt sales survey could s ... Full text Cite

Prevention, management, and rehabilitation of stroke in low- and middle-income countries.

Journal Article eNeurologicalSci · March 2016 Although stroke incidence in high-income countries (HICs) decreased over the past four decades, it increased dramatically in low- and middle-income countries (LMICs). In this review, we describe the current status of primary prevention, treatment, and mana ... Full text Link to item Cite

Comparison of Nonblood-Based and Blood-Based Total CV Risk Scores in Global Populations.

Journal Article Glob Heart · March 2016 BACKGROUND: Cost-effective primary prevention of cardiovascular disease (CVD) in low- and middle-income countries requires accurate risk assessment. Laboratory-based risk tools currently used in high-income countries are relatively expensive and impractica ... Full text Link to item Cite

Hypertension Prevalence, Awareness, Treatment, and Control in Selected LMIC Communities: Results From the NHLBI/UHG Network of Centers of Excellence for Chronic Diseases.

Journal Article Glob Heart · March 2016 BACKGROUND: Hypertension is the leading cause of cardiovascular disease and premature death worldwide. The prevalence of this public health problem is increasing in low- and middle-income countries (LMICs) in both urban and rural communities. OBJECTIVE: Th ... Full text Link to item Cite

Obesity and its Relation With Diabetes and Hypertension: A Cross-Sectional Study Across 4 Geographical Regions.

Journal Article Global heart · March 2016 BackgroundThe implications of rising obesity for cardiovascular health in middle-income countries has generated interest, in part because associations between obesity and cardiovascular health seem to vary across ethnic groups.ObjectiveWe ... Full text Cite

Prevalence of Pragmatically Defined High CV Risk and its Correlates in LMIC: A Report From 10 LMIC Areas in Africa, Asia, and South America.

Journal Article Global heart · March 2016 BackgroundCurrently available tools for assessing high cardiovascular risk (HCR) often require measurements not available in resource-limited settings in low- and middle-income countries (LMIC). There is a need to assess HCR using a pragmatic evid ... Full text Cite

Training and Capacity Building in LMIC for Research in Heart and Lung Diseases: The NHLBI-UnitedHealth Global Health Centers of Excellence Program.

Journal Article Glob Heart · March 2016 Stemming the tide of noncommunicable diseases (NCDs) worldwide requires a multipronged approach. Although much attention has been paid to disease control measures, there is relatively little consideration of the importance of training the next generation o ... Full text Link to item Cite

A feasibility study on using smartphones to conduct short-version verbal autopsies in rural China.

Journal Article Population health metrics · January 2016 BackgroundCurrently there are two main sources of mortality data with cause of death assignments in China. Both sources-the Ministry of Health-Vital Registration system and the Chinese Disease Surveillance Point system-present their own challenges ... Full text Cite

The Effects of a Community-Based Sodium Reduction Program in Rural China - A Cluster-Randomized Trial.

Journal Article PloS one · January 2016 BackgroundAverage sodium intake and stroke mortality in northern China are both among the highest in the world. An effective, low-cost strategy to reduce sodium intake in this population is urgently needed.ObjectiveWe sought to determine ... Full text Cite

A Cluster-Randomized, Controlled Trial of a Simplified Multifaceted Management Program for Individuals at High Cardiovascular Risk (SimCard Trial) in Rural Tibet, China, and Haryana, India.

Journal Article Circulation · September 2015 BackgroundIn rural areas in China and India, the cardiovascular disease burden is high but economic and healthcare resources are limited. This study (the Simplified Cardiovascular Management Study [SimCard]) aims to develop and evaluate a simplifi ... Full text Cite

Management of NCD in low- and middle-income countries.

Journal Article Global heart · December 2014 Noncommunicable disease (NCD), comprising cardiovascular disease, stroke, diabetes, and chronic obstructive pulmonary disease, are increasing in incidence rapidly in low- and middle-income countries (LMICs). Some patients have access to the same treatments ... Full text Cite

A cluster-randomized controlled trial to evaluate the effects of a simplified cardiovascular management program in Tibet, China and Haryana, India: Study design and rationale

Journal Article BMC Public Health · September 6, 2014 Methods/design. This yearlong cluster-randomized controlled trial will be conducted in 20 villages in Tibet and 20 villages in Haryana. Randomization of villages to usual care or intervention will be stratified by country. High cardiovascular disease risk ... Full text Cite

A cluster-randomized controlled trial to evaluate the effects of a simplified cardiovascular management program in Tibet, China and Haryana, India: study design and rationale.

Journal Article BMC public health · September 2014 BackgroundIn resource-poor areas of China and India, the cardiovascular disease burden is high, but availability of and access to quality healthcare is limited. Establishing a management scheme that utilizes the local infrastructure and builds hea ... Full text Cite

Effectiveness of a community-based individualized lifestyle intervention among older adults with diabetes and hypertension, Tianjin, China, 2008-2009.

Journal Article Preventing chronic disease · May 2014 IntroductionThough diet and exercise modification is effective in preventing diabetes and hypertension, community-based models for lifestyle intervention for managing these conditions that are practical and effective are few.MethodsA comm ... Full text Cite

Population impact of a high cardiovascular risk management program delivered by village doctors in rural China: design and rationale of a large, cluster-randomized controlled trial.

Journal Article BMC Public Health · April 11, 2014 BACKGROUND: The high-risk strategy has been proven effective in preventing cardiovascular disease; however, the population benefits from these interventions remain unknown. This study aims to assess, at the population level, the effects of an evidence-base ... Full text Open Access Link to item Cite

Using a low-sodium, high-potassium salt substitute to reduce blood pressure among Tibetans with high blood pressure: a patient-blinded randomized controlled trial.

Journal Article PloS one · January 2014 ObjectivesTo evaluate the effects of a low-sodium and high-potassium salt-substitute on lowering blood pressure (BP) among Tibetans living at high altitude (4300 meters).MethodThe study was a patient-blinded randomized controlled trial co ... Full text Cite

A large-scale cluster randomized trial to determine the effects of community-based dietary sodium reduction--the China Rural Health Initiative Sodium Reduction Study.

Journal Article American heart journal · November 2013 BackgroundCardiovascular diseases are the leading cause of death and disability in China. High blood pressure caused by excess intake of dietary sodium is widespread and an effective sodium reduction program has potential to improve cardiovascular ... Full text Cite

Validation of the Omron HEM-7201 upper arm blood pressure monitor, for self-measurement in a high-altitude environment, according to the European Society of Hypertension International Protocol revision 2010.

Journal Article Journal of human hypertension · August 2013 Few studies have been conducted on blood pressure monitors and their use at high altitude. This study is the first to evaluate the accuracy of an automatic blood pressure monitor in a high-altitude environment following a standard validation protocol. The ... Full text Cite

A School-based Education Programme to Reduce salt intake in children and their families (School-EduSalt): Protocol of a cluster randomised controlled trial

Journal Article BMJ Open · July 30, 2013 Introduction: The current salt intake is very high for children as well as adults in China. A reduction in salt intake is one of the most cost-effective measures to curb the rapidly growing disease burden attributed to blood pressure and cardiovascular dis ... Full text Cite

Research misconduct in low- and middle-income countries.

Journal Article PLoS medicine · January 2013 As part of a cluster of articles critically reflecting on the theme of "no health without research," Richard Smith and colleagues lay out what is currently known about research misconduct in low- and middle-income countries, summarizing some high profile c ... Full text Cite

BMI at younger ages and health-related quality of life in older age

Journal Article · December 1, 2012 Overweight/obesity (body mass index [BMI] of 25.0-29.9 and ≥ 30.0 kg/m2 respectively)-now recognized as a major modifiable risk factor-is associated with higher risk of cardiovascular and non-cardiovascular morbidity and mortality, higher health care costs ... Cite

Effect of a school-based peer education intervention on physical activity and sedentary behaviour in Chinese adolescents: A pilot study

Journal Article BMJ Open · July 16, 2012 Objective: To evaluate the effect on physical activity and sedentary behaviour of a pilot school-based peer education programme in urban Beijing, China. Design: 4 junior high schools were matched by school size and randomised to intervention (n=346) and co ... Full text Cite

Prevalence, awareness, treatment, and control of hypertension among herdsmen living at 4,300 m in Tibet.

Journal Article American journal of hypertension · May 2012 BackgroundStudies on blood pressure (BP) in high-altitude areas are scarce and the results are controversial. Tibetans live in regions at high altitudes, and data on the prevalence of hypertension in this population is not currently well known. Full text Cite

Can electronic sphygmomanometers be used for measurement of blood pressure at high altitudes?

Journal Article Blood pressure monitoring · April 2012 ObjectiveValidated automated oscillometric sphygmomanometers have been recommended by clinical guidelines to replace mercury sphygmomanometers. No studies have been conducted to evaluate whether these validated devices designed for use at normal a ... Full text Cite

Twenty-year trends in the prevalence of disability in China.

Journal Article Bulletin of the World Health Organization · November 2011 ObjectiveTo evaluate changes in the age-adjusted prevalence of disability in transitional China from 1987 to 2006.MethodsData from nationally representative surveys conducted in 1987 and 2006 were used to calculate age-adjusted disability ... Full text Cite

Global response to non-communicable disease.

Journal Article BMJ (Clinical research ed.) · June 2011 Full text Cite

Salt Restriction and Challenges in China for Hypertension Control

Journal Article Current Cardiovascular Risk Reports · April 1, 2011 This article reviews the best evidence currently available worldwide on the causal relationship between salt intake and blood pressure and its related diseases. The evidence clearly demonstrates that high salt intake causes blood pressure increases and tha ... Full text Cite

The authors reply

Journal Article American Journal of Epidemiology · March 1, 2010 Full text Cite

Gender differences in the association between sleep duration and body composition: The CARDIA study

Journal Article International Journal of Endocrinology · January 1, 2010 Sleep duration has been inversely associated with body mass index (BMI). We examined the relationship between self-reported sleep duration and BMI, waist circumference, and percent body fat in Black and White individuals from the CARDIA study. Box-Tidwell ... Full text Cite

Responding to China's hypertensive crisis.

Journal Article Lancet (London, England) · November 2009 Full text Cite

Cross-sectional and longitudinal associations between objectively measured sleep duration and body mass index: the CARDIA Sleep Study.

Journal Article American journal of epidemiology · October 2009 Numerous studies have found an association between shorter sleep duration and higher body mass index (BMI) in adults. Most previous studies have been cross-sectional and relied on self-reported sleep duration, which may not be very accurate. In the Coronar ... Full text Cite

Lauderdale et al. respond to "understanding the role of sleep"

Journal Article American Journal of Epidemiology · October 1, 2009 Full text Cite

Association between sleep and blood pressure in midlife: the CARDIA sleep study.

Journal Article Archives of internal medicine · June 2009 BackgroundEpidemiological studies have reported an association between self-reported short sleep duration and high blood pressure (BP). Our objective was to examine both cross-sectional and longitudinal associations between objectively measured sl ... Full text Cite

Self-reported and measured sleep duration: how similar are they?

Journal Article Epidemiology (Cambridge, Mass.) · November 2008 BackgroundRecent epidemiologic studies have found that self-reported duration of sleep is associated with obesity, diabetes, hypertension, and mortality. The extent to which self reports of sleep duration are similar to objective measures and whet ... Full text Cite

Resting heart rate in middle age and diabetes development in older age.

Journal Article Diabetes care · February 2008 ObjectiveBased on prior research showing inverse associations between heart rate and life expectancy, we tested the hypothesis that adults with higher resting heart rate in middle age were more likely to have diagnosed diabetes or to experience di ... Full text Cite

Relation of heart rate with cardiovascular disease in normal-weight individuals: the Chicago Heart Association Detection Project in Industry.

Journal Article Preventive cardiology · January 2008 The authors investigated the association of resting heart rate (RHR) with cardiovascular disease (CVD) risk factors and mortality among normal-weight individuals. Using data from our cohort (baseline examination in 1967-1973), individuals with a body mass ... Full text Cite

Intra-individual daily and yearly variability in actigraphically recorded sleep measures: the CARDIA study.

Journal Article Sleep · June 2007 Study objectivesTo describe the day-to-day and year-to-year variation in sleep characteristics among early middle-aged adults.DesignParticipants wore an Actiwatch (Mini Mitter, Inc) for 3 days on two occasions approximately 1 year apart.< ... Full text Cite

Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study.

Journal Article Circulation · February 2007 BackgroundData are sparse regarding the association of stable body mass index (BMI) over the long term with metabolic syndrome components in young adults.Methods and resultsParticipants in the Coronary Artery Risk Development in Young Adu ... Full text Cite

The authors reply [4]

Journal Article American Journal of Epidemiology · January 1, 2007 Full text Cite

Stability of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Questionnaires over 1 year in early middle-aged adults: the CARDIA study.

Journal Article Sleep · November 2006 Study objectivesTo describe the stability of the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) scores over 1 year among a population-based sample of black and white early middle-aged adults.ParticipantsMore ... Full text Cite

Lauderdale et al. respond to "How much do we really sleep?"

Journal Article American Journal of Epidemiology · July 1, 2006 Full text Cite

Objectively measured sleep characteristics among early-middle-aged adults: the CARDIA study.

Journal Article American journal of epidemiology · July 2006 Despite mounting evidence that sleep duration is a risk factor across diverse health and functional domains, little is known about the distribution and determinants of sleep. In 2003-2004, the authors used wrist activity monitoring and sleep logs to measur ... Full text Cite

Midlife Body Mass Index and Total Mortality-Reply

Journal Article JAMA · April 19, 2006 Full text Cite

Education, 15-year risk factor progression, and coronary artery calcium in young adulthood and early middle age: the Coronary Artery Risk Development in Young Adults study.

Journal Article JAMA · April 2006 ContextThe inverse association between education and cardiovascular disease is well established, but little is known about the relationship between education and subclinical disease, which is free from medical access and treatment-related influenc ... Full text Cite

Midlife body mass index and hospitalization and mortality in older age.

Journal Article JAMA · January 2006 ContextAbundant evidence links overweight and obesity with impaired health. However, controversies persist as to whether overweight and obesity have additional impact on cardiovascular outcomes independent of their strong associations with establi ... Full text Cite

Regional material property alterations in porcine femoral arteries with atheroma development.

Journal Article Journal of biomechanics · December 2005 We have developed a novel methodology that permits assessment of regional vascular mechanical property alterations in the presence of atheroma in vivo employing a Yucatan miniswine model with induced lesions. Femoral arteries were imaged with intravascular ... Full text Cite

Relationship of fruit and vegetable consumption in middle-aged men to medicare expenditures in older age: the Chicago Western Electric Study.

Journal Article Journal of the American Dietetic Association · November 2005 BackgroundHigh fruit and vegetable intake is associated with lower risk of hypertension, cardiovascular disease, and cancer. Little is known about the relationship of fruit and vegetable intake to health care expenditures.ObjectiveExamine ... Full text Cite

Cardiovascular risk profile earlier in life and Medicare costs in the last year of life.

Journal Article Archives of internal medicine · May 2005 BackgroundHealth care costs are generally highest in the year before death, and much attention has been directed toward reducing costs for end-of-life care. However, it is unknown whether cardiovascular risk profile earlier in life influences heal ... Full text Cite

Role of psychosocial factors in hypertension

Journal Article Cardiology Review · April 1, 2005 We examined the effect of psychosocial factors-including time urgency/impatience, achievement/striving/competitiveness, hostility, depression, and anxiety-on long-term risk of hypertension in a young adult, urban cohort. Of these five psychosocial factors, ... Cite

Porcine carotid arterial material property alterations with induced atheroma: an in vivo study.

Journal Article Medical engineering & physics · March 2005 ObjectiveA novel methodology has been developed to evaluate regional alterations in arterial wall material properties with induced atheroma in an animal model.MethodsAtheromatous lesions (fatty, fibro-fatty, and fibrous) were induced in t ... Full text Cite

Relation of nutrient intake to microalbuminuria in nondiabetic middle-aged men and women: International Population Study on Macronutrients and Blood Pressure (INTERMAP).

Journal Article American journal of kidney diseases : the official journal of the National Kidney Foundation · February 2005 BackgroundMicroalbuminuria (MA) is a risk factor for cardiovascular and renal disease. However, little is known about the relation of nutritional factors to MA, especially in individuals without diabetes.MethodsData collected by the Inter ... Full text Cite

Relation of body mass index in young adulthood and middle age to Medicare expenditures in older age.

Journal Article JAMA · December 2004 ContextIncreasing prevalence of overweight/obesity and rapid aging of the US population have raised concerns of increasing health care costs, with important implications for Medicare. However, little is known about the impact of body mass index (B ... Full text Cite

Favorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality.

Journal Article JAMA · October 2004 ContextFor women, impact of cardiovascular risk factors measured in young adulthood, particularly favorable (low-risk) profile, on mortality has been difficult to assess due to low short-term death rates.ObjectiveTo assess the relationshi ... Full text Cite

Comparison of low risk and higher risk profiles in middle age to frequency and quantity of coronary artery calcium years later.

Journal Article The American journal of cardiology · August 2004 Little is known about the relation of having favorable levels of all major cardiovascular risk factors (low risk [LR]) earlier in life to coronary artery calcium (CAC) later in life. From 2002 to 2003, CAC was compared in participants aged >60 years who we ... Full text Cite

Blood pressure differences between northern and southern Chinese: role of dietary factors: the International Study on Macronutrients and Blood Pressure.

Journal Article Hypertension (Dallas, Tex. : 1979) · June 2004 Blood pressure and prevalence of high blood pressure are greater for northern than southern Chinese. Reasons for these differences are unclear. Relationships of north-south blood pressure differences with multiple dietary factors were investigated in 839 C ... Full text Cite

Alteration in fluid mechanics in porcine femoral arteries with atheroma development.

Journal Article Annals of biomedical engineering · April 2004 Although the relationship between the local wall shear stresses (WSS) and atheroma development has been previously studied, the effect of variable regional wall distensibility with early atherosclerotic lesions and its effect on local hemodynamics have not ... Full text Cite

BMI and health-related quality of life in adults 65 years and older.

Journal Article Obesity research · January 2004 ObjectiveTo examine relationships of BMI with health-related quality of life in adults 65 years and older.Research methods and proceduresIn 1996, a health survey was mailed to all surviving participants > or = 65 years old from the Chicag ... Full text Cite

International collaborative study of cardiovascular disease in Asia: design, rationale, and preliminary results.

Journal Article Ethnicity & disease · January 2004 ObjectivesThe overall objective of the International Collaborative Study of Cardiovascular Disease in Asia (InterASIA) was to estimate the prevalence and distribution of cardiovascular disease risk factors, including hypertension, hypercholesterol ... Cite

Response rates to a questionnaire 26 years after baseline examination with minimal interim participant contact and baseline differences between respondents and nonrespondents.

Journal Article American journal of epidemiology · January 2004 Research on response rates to surveys mailed to study participants decades after baseline examination, with minimal interim contact, is limited. This paper documents response rates to a 26-year follow-up survey of surviving participants from a large cohort ... Full text Cite

Body mass index in middle age and health-related quality of life in older age: the Chicago heart association detection project in industry study.

Journal Article Archives of internal medicine · November 2003 BackgroundOverweight and obesity are associated with higher morbidity and shorter life expectancy, but the effect of body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) ascertained during middle age ... Full text Cite

Favorable cardiovascular risk profile in middle age and health-related quality of life in older age.

Journal Article Archives of internal medicine · November 2003 BackgroundLife expectancy is greater for people with favorable midlife cardiovascular risk profiles (ie, low risk). However, some speculate that increased longevity may lead to large numbers of ill, disabled, older persons with lower quality of li ... Full text Cite

Psychosocial factors and risk of hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Journal Article JAMA · October 2003 ContextAlthough psychosocial factors are correlated, previous studies on risk factors for hypertension have typically examined psychosocial factors individually and have yielded inconsistent findings.ObjectiveTo examine the role of psycho ... Full text Cite

Alteration in fluid mechanics in femoral arteries with atheroma development

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings · December 1, 2002 The relationship between regional alterations in wall motion, normalized wall shear amplitude (NWSA), and atheromatic lesion composition was evaluated in the Yucatan miniswine model with developing atherosclerosis. We induced vascular lesions by endothelia ... Cite