Scholars@Duke
Marco Pardini Gontijo

Selected Publications

Violacein-Loaded Outer Membrane Vesicles from <i>Salmonella enterica</i> Exhibit Potent Anti-Melanoma Activity <i>in Vitro</i> and <i>in Vivo</i>.

Journal Article ACS biomaterials science & engineering · October 2025 Violacein exhibits antitumor activity, indicating potential for future clinical application. However, an efficient delivery system is required for the clinical use of this hydrophobic compound. Effective delivery systems can enhance the solubility and bioa ... Full text Cite

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.

Journal Article PLoS Biol · September 2025 Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB dise ... Full text Link to item Cite

Application of Conservation Strategies for Bacteriophages Used in the Biocontrol of Pathogenic Microorganisms in Food

Journal Article Journal of Food Safety · February 1, 2025 The encapsulation of bacteriophages shows significant potential as a biocontrol strategy in the food industry. This review explores diverse strategies, including freeze-drying, spray-drying, and extrusion dripping, along with the macromolecular matrices us ... Full text Cite

Physicochemical, textural and organoleptic characteristics of costeño cheese: An autochthonous product of the Colombian Caribbean coast

Journal Article International Dairy Journal · January 1, 2025 This research sought to identify and analyse the main contributions of the work carried out on Costeño cheese and that can contribute to improving and characterizing the production system and the physicochemical, rheological and sensory characteristics of ... Full text Cite

High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape

Journal Article Cell Genomics · January 1, 2025 We present a collection of 17 high-quality long-read inbred mouse strain genomes with complete annotation (contig N50s of 0.8–33.9 Mbp). This collection includes 12 widely used classical laboratory strains and 5 wild-derived strains. We have resolved previ ... Full text Cite

Combined effect of SAR-endolysin LysKpV475 with polymyxin B and Salmonella bacteriophage phSE-5.

Journal Article Microbiology (Reading, England) · May 2024 Endolysins are bacteriophage (or phage)-encoded enzymes that catalyse the peptidoglycan breakdown in the bacterial cell wall. The exogenous action of recombinant phage endolysins against Gram-positive organisms has been extensively studied. However, the ou ... Full text Cite

Attenuated mutants of Salmonella enterica Typhimurium mediate melanoma regression via an immune response.

Journal Article Experimental biology and medicine (Maywood, N.J.) · January 2024 The lack of effective treatment options for an increasing number of cancer cases highlights the need for new anticancer therapeutic strategies. Immunotherapy mediated by Salmonella enterica Typhimurium is a promising anticancer treatment. Candidate ... Full text Cite

Biovalorization of Agri-waste for the Production of Polyphenols

Chapter · January 1, 2023 The losses related to the disposal of food represent direct financial disadvantages and water, agrarian, and input resources. Agro-industrial wastes, rich in biomass and organic matter, represent a significant source of biological compounds of interest for ... Full text Cite

Complete genome analysis of Tequatrovirus ufvareg1, a Tequatrovirus species inhibiting Escherichia coli O157:H7.

Journal Article Frontiers in cellular and infection microbiology · January 2023 IntroductionBacteriophages infecting human pathogens have been considered potential biocontrol agents, and studying their genetic content is essential to their safe use in the food industry. Tequatrovirus ufvareg1 is a bacteriophage named U ... Full text Cite

Salmonella enterica and outer membrane vesicles are current and future options for cancer treatment.

Journal Article Frontiers in cellular and infection microbiology · January 2023 Conventional cancer therapies have many limitations. In the last decade, it has been suggested that bacteria-mediated immunotherapy may circumvent the restrictions of traditional treatments. For example, Salmonella enterica is the most promising bac ... Full text Cite

Mining Biosynthetic Gene Clusters in Carnobacterium maltaromaticum by Interference Competition Network and Genome Analysis.

Journal Article Microorganisms · September 2022 Carnobacterium maltaromaticum is a non-starter lactic acid bacterium (LAB) of interest in the dairy industry for biopreservation. This study investigated the interference competition network and the specialized metabolites biosynthetic gene clusters ... Full text Open Access Cite

Virulence and DNA sequence analysis of Cronobacter spp. isolated from infant cereals.

Journal Article International journal of food microbiology · September 2022 Cronobacter spp. is an opportunistic pathogen that causes severe infections, affecting newborns and infants, and is also an emerging cause of hospital-acquired infection in elderly populations. These infections are mainly associated with the consumption of ... Full text Open Access Cite

Antimicrobial resistance and genetic background of non-typhoidal Salmonella enterica strains isolated from human infections in São Paulo, Brazil (2000-2019).

Journal Article Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · September 2022 Salmonella enterica causes Salmonellosis, an important infection in humans and other animals. The number of multidrug-resistant (MDR) phenotypes associated with Salmonella spp. isolates is increasing worldwide, causing public health concern. Here, we aim t ... Full text Open Access Cite

EbfC/YbaB: A Widely Distributed Nucleoid-Associated Protein in Prokaryotes.

Journal Article Microorganisms · September 2022 Genomic compaction is an essential characteristic of living organisms. Nucleoid-associated proteins (NAPs) are a group of small proteins that play crucial roles in chromosome architecture and affect DNA replication, transcription, and recombination by impo ... Full text Open Access Cite

Expanding the Database of Signal-Anchor-Release Domain Endolysins Through Metagenomics.

Journal Article Probiotics and antimicrobial proteins · August 2022 Endolysins are bacteriophage-derived lytic enzymes with antimicrobial activity. The action of endolysins against Gram-negative bacteria remains a challenge due to the physical protection of the outer membrane. However, recent research has demonstrated that ... Full text Open Access Cite

Expanding the genomes insight of Streptococcus thermophilus phages through a multifaceted approach

Journal Article Research, Society and Development · July 30, 2022 Viruses have complex evolutionary relationships, and several strategies have been used in an attempt to classify the phages that infect S. thermophilus. In this study, we used a wide range of complementary methods, including comparative genomics, c ... Full text Cite

Genomic Characterisation of UFJF_PfDIW6: A Novel Lytic Pseudomonas fluorescens-Phage with Potential for Biocontrol in the Dairy Industry.

Journal Article Viruses · March 2022 In this study, we have presented the genomic characterisation of UFJF_PfDIW6, a novel lytic Pseudomonas fluorescens-phage with potential for biocontrol in the dairy industry. This phage showed a short linear double-stranded DNA genome (~42 kb) with ... Full text Open Access Cite

Les misérables: a Parallel Between Antimicrobial Resistance and COVID-19 in Underdeveloped and Developing Countries.

Journal Article Current infectious disease reports · January 2022 Purpose of reviewThe COVID-19 pandemic has been responsible for more than 6.3 million deaths worldwide. During the pandemic, the indiscriminate use of antibiotics has increased, contributing to the spread of multidrug-resistant bacteria. In this r ... Full text Open Access Cite

Correction to: Les misérables: A Parallel Between Antimicrobial Resistance and COVID‑19 in Underdeveloped and Developing Countries.

Journal Article Current infectious disease reports · January 2022 [This corrects the article DOI: 10.1007/s11908-022-00788-z.]. ... Full text Cite

Current Status of Endolysin-Based Treatments against Gram-Negative Bacteria.

Journal Article Antibiotics (Basel, Switzerland) · September 2021 The prevalence of multidrug-resistant Gram-negative bacteria is a public health concern. Bacteriophages and bacteriophage-derived lytic enzymes have been studied in response to the emergence of multidrug-resistant bacteria. The availability of tRNAs and en ... Full text Open Access Cite

Bacteriophages that infect Gram-negative bacteria as source of signal-arrest-release motif lysins.

Journal Article Research in microbiology · March 2021 Treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria is challenging, a potential solution for which is the use of bacteriophage-derived lytic enzymes. However, the exogenous action of bacteriophage lysins against Gram-negative ... Full text Open Access Cite

Encapsulation in alginate-polymers improves stability and allows controlled release of the UFV-AREG1 bacteriophage.

Journal Article Food research international (Ottawa, Ont.) · January 2021 The bacteriophage UFV-AREG1 was used as a model organism to evaluate the encapsulation via extrusion using different hydrocolloids. Pure alginate [0.75%, 1.0%, 1.5% and 2.0% (m/v)] and mixtures of alginate [0.75% or 1.0% (m/v)] with carrageenan [1.25% (m/v ... Full text Open Access Cite

Phylogenetic distribution of the bacteriocin repertoire of lactic acid bacteria species associated with artisanal cheese.

Journal Article Food research international (Ottawa, Ont.) · February 2020 The microbiota contributes to artisanal cheese bioprotection and biopreservation through inter and intraspecific competition. This work aimed to investigate the phylogenetic distribution of the repertoire of bacteriocin structural genes of model lactic aci ... Full text Open Access Cite

INTRODUCTION

Journal Article ITALIAN JOURNAL OF FOOD SCIENCE · 2019 Cite

Evaluation of microencapsulation of the UFV-AREG1 bacteriophage in alginate-Ca microcapsules using microfluidic devices.

Journal Article Colloids and surfaces. B, Biointerfaces · October 2017 The indiscriminate use of antibiotics and the emergence of resistant microorganisms have become a major challenge for the food industry. The purpose of this work was to microencapsulate the bacteriophage UFV-AREG1 in a calcium alginate matrix using microfl ... Full text Open Access Cite

Genome Sequence of the Enterohemorrhagic Escherichia coli Bacteriophage UFV-AREG1.

Journal Article Genome announcements · October 2016 Here, we present the genome sequence of the Escherichia coli bacteriophage UFV-AREG1. This phage was isolated from cowshed wastewater and showed specificity for enterohemorrhagic E. coli O157:H7 (ATCC 43895), E. coli 0111 (CDC O11ab) and E. coli (ATCC 2322 ... Full text Open Access Cite