Scholars@Duke
Mark William Onaitis

Mark William Onaitis

Adjunct Associate Professor in the Department of Surgery
Surgery, Cardiovascular and Thoracic Surgery
mark.onaitis@duke.edu
Box 3305 Med Ctr, Durham, NC 27710
Dept of Surgery, Durham, NC 27710

Selected Publications

Lobectomy vs Sublobar Resection in The Society of Thoracic Surgeons Database: Importance of Patient Factors and Lymph Node Evaluation.

Journal Article Ann Thorac Surg · January 24, 2025 BACKGROUND: Prospective randomized trials have demonstrated noninferior survival between sublobar resection and lobectomy in healthy patients with non-small cell lung cancer with tumors ≤2 cm. However, some patient attributes are not well represented in ra ... Full text Link to item Cite

NCCN Guidelines® Insights: Lung Cancer Screening, Version 1.2025.

Journal Article J Natl Compr Canc Netw · January 2025 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide criteria for selecting individuals for screening and offer recommendations for evaluating and managing lung nodules detected during initial and subsequent ... Full text Link to item Cite

Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.

Journal Article Cancer Res · May 15, 2024 UNLABELLED: Cancer stem/tumor-initiating cells display stress tolerance and metabolic flexibility to survive in a harsh environment with limited nutrient and oxygen availability. The molecular mechanisms underlying this phenomenon could provide targets to ... Full text Link to item Cite

A Multidisciplinary Minimally Invasive Approach Is Necessary for the Contemporary Management of Esophageal Diverticula.

Journal Article J Laparoendosc Adv Surg Tech A · April 2024 Background: Esophageal diverticula were traditionally treated with open surgery, which is associated with significant morbidity and mortality rates. Management has shifted to minimally invasive approaches with several advantages. We examine outcomes in pat ... Full text Link to item Cite

Activation of KrasG12D in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma.

Journal Article Cancer Res Commun · November 24, 2023 UNLABELLED: We have previously identified alveolar type II cell as the cell-of-origin of KrasG12D-induced lung adenocarcinoma using cell lineage-specific inducible Cre mouse models. Using gain-of-function and loss-of-function genetic models, we discovered ... Full text Link to item Cite

Tolerability and Feasibility of the Upper Esophageal Sphincter Assist Device in Preventing Acute and Chronic Allograft Rejection Among Lung Transplant Recipients.

Conference J Clin Gastroenterol · July 1, 2023 GOALS: We aimed to evaluate a novel upper esophageal sphincter (UES) assist device loaner program for the prevention of acute cellular rejection and chronic lung allograft dysfunction among lung transplant (LTx) recipients. BACKGROUND: Laryngopharyngeal re ... Full text Link to item Cite

Discussion.

Journal Article J Thorac Cardiovasc Surg · July 2023 Full text Link to item Cite

Robotic Ivor-Lewis esophagectomy in 15 steps

Journal Article JTCVS Techniques · June 1, 2023 Full text Cite

Racial and ethnic variation in referral times for thoracic oncologic surgery in a major metropolitan area.

Conference J Thorac Cardiovasc Surg · February 2023 OBJECTIVE: The study objective was to understand the impact of race/ethnicity on access to thoracic surgical care for patients undergoing lung resection for cancer. METHODS: We performed a retrospective analysis on 206 consecutive patients who underwent lu ... Full text Link to item Cite

Discussion.

Journal Article J Thorac Cardiovasc Surg · January 2023 Full text Link to item Cite

The Society of Thoracic Surgeons General Thoracic Surgery Database: 2022 Update on Outcomes and Research.

Journal Article Ann Thorac Surg · January 2023 The Society of Thoracic Surgeons General Thoracic Surgery Database (STS GTSD) remains the largest and most robust thoracic surgical database in the world. Participating sites receive risk-adjusted performance reports for benchmarking and quality improvemen ... Full text Link to item Cite

Lymphadenectomy During Sublobar Resections

Chapter · January 1, 2023 Lymph node dissection is necessary for adequate staging of the patient, and it facilitates dissection of vessels and bronchi. The American College of Surgeons Commission on Cancer recommends lymph node removal from three mediastinal and one hilar lymph nod ... Full text Cite

The Role of Chemotherapy Plus Immune Checkpoint Inhibitors in Oncogenic-Driven NSCLC: A University of California Lung Cancer Consortium Retrospective Study.

Journal Article JTO Clin Res Rep · December 2022 INTRODUCTION: There is a paucity of data on immune checkpoint inhibitors (ICIs) plus doublet chemotherapy (C) in patients with advanced lung cancer whose tumor harbors an actionable mutation. We sought to provide insight into the role of this combination i ... Full text Link to item Cite

Consensus for Thoracoscopic Lower Lobectomy: Essential Components and Targets for Simulation.

Journal Article Ann Thorac Surg · November 2022 BACKGROUND: Despite demonstration of its clear benefits relative to open approaches, a video-assisted thoracic surgery technique for pulmonary lobectomy has not been universally adopted. This study aims to overcome potential barriers by establishing the es ... Full text Link to item Cite

NCCN Guidelines® Insights: Lung Cancer Screening, Version 1.2022.

Journal Article J Natl Compr Canc Netw · July 2022 The NCCN Guidelines for Lung Cancer Screening recommend criteria for selecting individuals for screening and provide recommendations for evaluation and follow-up of lung nodules found during initial and subsequent screening. These NCCN Guidelines Insights ... Full text Link to item Cite

Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions.

Journal Article Nat Commun · May 26, 2022 Development of the gastrointestinal system occurs after gut tube closure, guided by spatial and temporal control of gene expression. However, it remains unclear what forces regulate these spatiotemporal gene expression patterns. Here we perform single-cell ... Full text Link to item Cite

Risk of Acute Lung Injury after Esophagectomy.

Journal Article Semin Thorac Cardiovasc Surg · 2022 To develop a new approach for identifying acute lung injury (ALI) in surgical ward setting and to assess incidence rate, clinical outcomes, and risk factors for ALI cases after esophagectomy. We also compare the degree of lung injury between operative and ... Full text Link to item Cite

Minimally invasive thymectomy for myasthenia gravis favours left-sided approach and low severity class.

Journal Article Eur J Cardiothorac Surg · October 22, 2021 OBJECTIVES: Complete thymectomy is a key component of the optimal treatment for myasthenia gravis. Unilateral, minimally invasive approaches are increasingly utilized with debate about the optimal laterality approach. A right-sided approach has a wider fie ... Full text Link to item Cite

Commentary: Minimally invasive esophagectomy: Steady progress.

Journal Article J Thorac Cardiovasc Surg · September 2021 Full text Link to item Cite

It's not always too late: a case for minimally invasive salvage esophagectomy.

Journal Article Surg Endosc · August 2021 INTRODUCTION: Standard of care for locally advanced esophageal carcinoma is neoadjuvant chemoradiation (nCRT) and surgical resection 4-8 weeks after completion of nCRT. It is recommended that the CRT to surgery interval not exceed 90 days. Many patients do ... Full text Link to item Cite

Consensus for Thoracoscopic Left Upper Lobectomy-Essential Components and Targets for Simulation.

Journal Article Ann Thorac Surg · August 2021 BACKGROUND: Simulation-based training is a valuable component of cardiothoracic surgical education. Effective curriculum development requires consensus on procedural components and focused attention on specific learning objectives. Through use of a Delphi ... Full text Link to item Cite

Readmission After Lobectomy for Lung Cancer: Not All Complications Contribute Equally.

Journal Article Ann Surg · July 1, 2021 OBJECTIVE: The aim of this study was to identify independent predictors of hospital readmission for patients undergoing lobectomy for lung cancer. SUMMARY BACKGROUND DATA: Hospital readmission after lobectomy is associated with increased mortality. Greater ... Full text Link to item Cite

Initial and Longitudinal Cost of Surgical Resection for Lung Cancer.

Journal Article Ann Thorac Surg · June 2021 BACKGROUND: The longitudinal cost of treating patients with non-small cell lung cancer (NSCLC) undergoing surgical resection has not been evaluated. We describe initial and 4-year resource use and cost for NSCLC patients aged 65 years of age or greater who ... Full text Link to item Cite

Costs Associated With Lobectomy for Lung Cancer: An Analysis Merging STS and Medicare Data.

Journal Article Ann Thorac Surg · June 2021 BACKGROUND: Costs related to care of patients who undergo lobectomy for lung cancer may vary depending on patient, disease, and treating facility characteristics. We aimed to identify underlying case mix factors that contribute to variability of 90-day cos ... Full text Link to item Cite

Commentary: Ischemia reperfusion-Looking ahead.

Journal Article J Thorac Cardiovasc Surg · February 2021 Full text Link to item Cite

Equivalent Survival Between Lobectomy and Segmentectomy for Clinical Stage IA Lung Cancer.

Journal Article Ann Thorac Surg · December 2020 BACKGROUND: The oncologic efficacy of segmentectomy is controversial. We compared long-term survival in clinical stage IA (T1N0) Medicare patients undergoing lobectomy and segmentectomy in The Society of Thoracic Surgeons database. METHODS: The Society of ... Full text Link to item Cite

Discussion.

Journal Article J Thorac Cardiovasc Surg · October 2020 Full text Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Prior tonsillectomy is associated with an increased risk of esophageal adenocarcinoma.

Journal Article PLoS One · 2020 BACKGROUND: Esophageal cancer is a deadly cancer with 5-year survival <20%. Although multiple risk factors for esophageal adenocarcinoma (EAC) including obesity, GERD and smoking have been identified, these risk factors do not fully explain the rising inci ... Full text Link to item Cite

A 37-Year-Old Man With Pleuritic Chest Pain.

Journal Article Chest · July 2019 A 37-year-old man with poorly controlled type 2 diabetes presented with severe right-sided pleuritic chest pain, respiratory splinting, and cough. Two weeks earlier, he had been evaluated at an urgent care for cough and was prescribed a 5-day course of azi ... Full text Link to item Cite

Right-Sided Versus Left-Sided Pneumonectomy After Induction Therapy for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · April 2019 BACKGROUND: A right-sided pneumonectomy after induction therapy for non-small cell lung cancer (NSCLC) has been shown to be associated with significant perioperative risk. We examined the effect of laterality on long-term survival after induction therapy a ... Full text Link to item Cite

Lack of correlation between short- and long-term performance after lung cancer surgery.

Journal Article J Thorac Cardiovasc Surg · April 2019 OBJECTIVE: Outcomes for lung cancer surgery are currently measured according to perioperative morbidity and mortality. However, the oncologic efficacy of the surgery is reflected by long-term survival. We examined correlation between measures of short-term ... Full text Link to item Cite

Comparative study of anatomic lung resection by robotic vs. Video-assisted thoracoscopic surgery

Journal Article Journal of Thoracic Disease · April 1, 2019 Background: Comparative studies of robotic lung resection are limited. Our study aims to compare short-term and long-term outcomes of anatomic lung resection by robotic or video-assisted thoracoscopic surgery (VATS) from a single surgeon experienced in bot ... Full text Cite

Penetration, Completeness, and Representativeness of The Society of Thoracic Surgeons General Thoracic Surgery Database for Lobectomy.

Journal Article Ann Thorac Surg · March 2019 BACKGROUND: Not all surgeons performing lobectomy in the United States report outcomes to The Society of Thoracic Surgeons General Thoracic Surgery Database (STS GTSD). We examined penetration, completeness, and representativeness of the STS GTSD for lobec ... Full text Link to item Cite

Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial.

Journal Article Lancet Neurol · March 2019 BACKGROUND: The Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone (MGTX) showed that thymectomy combined with prednisone was superior to prednisone alone in improving clinical status as measured by the Quantitative Myasthe ... Full text Link to item Cite

Minimally Invasive Lung Cancer Surgery Performed by Thoracic Surgeons as Effective as Thoracotomy.

Journal Article J Clin Oncol · August 10, 2018 Purpose The prevalence of minimally invasive lung cancer surgery using video-assisted thoracic surgery (VATS) has increased dramatically over the past decade, yet recent studies have suggested that the lymph node evaluation during VATS lobectomy is inadequ ... Full text Link to item Cite

Transcriptional signature primes human oral mucosa for rapid wound healing.

Journal Article Sci Transl Med · July 25, 2018 Oral mucosal wound healing has long been regarded as an ideal system of wound resolution. However, the intrinsic characteristics that mediate optimal healing at mucosal surfaces are poorly understood, particularly in humans. We present a unique comparative ... Full text Link to item Cite

Differential effects of operative complications on survival after surgery for primary lung cancer.

Journal Article The Journal of thoracic and cardiovascular surgery · March 2018 ObjectiveComplications adversely affect survival after lung cancer surgery. We tested the hypothesis that effects of complications after lung cancer surgery on survival vary substantially across the spectrum of postoperative complications.Meth ... Full text Cite

Prediction of Long-Term Survival After Lung Cancer Surgery for Elderly Patients in The Society of Thoracic Surgeons General Thoracic Surgery Database.

Journal Article Ann Thorac Surg · January 2018 BACKGROUND: Prior risk models using the STS General Thoracic Surgery database (STS-GTSD) have been limited to 30-day outcomes. We have now linked STS data to Medicare data and sought to create a risk prediction model for long-term mortality after lung canc ... Full text Link to item Cite

Lymph node assessment and survival: We still have work to do

Journal Article Journal of Thoracic Disease · January 1, 2018 Full text Cite

Improved Survival of Stage I Non-Small Cell Lung Cancer: A VA Central Cancer Registry Analysis.

Journal Article J Thorac Oncol · December 2017 INTRODUCTION: The combined impact of advances in diagnosis and treatment of stage I NSCLC has not been assessed comprehensively. To define the survival impact of modern staging and treatment techniques for clinical stage I NSCLC, the Veterans Administratio ... Full text Link to item Cite

High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma.

Journal Article Radiat Res · November 2017 High-linear energy transfer (LET) radiation encountered by astronauts in space generates clustered DNA damage that is potentially oncogenic. Analysis of the impact of exposure to space radiation on cancer formation is necessary to determine the best ways t ... Full text Link to item Cite

The Society of Thoracic Surgeons General Thoracic Surgery Database: 2017 Update on Research.

Journal Article Ann Thorac Surg · November 2017 The outcomes research efforts based on The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database include two established research programs with dedicated task forces and with data analyses conducted at the STS data analytic center: (1) The S ... Full text Link to item Cite

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.

Journal Article Anesth Analg · October 2017 BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated w ... Full text Open Access Link to item Cite

Consensus statement on definitions and nomenclature for robotic thoracic surgery.

Journal Article J Thorac Cardiovasc Surg · September 2017 OBJECTIVES: Robotic thoracic operations are increasing, and new robotic systems are imminent. A definition of what constitutes a robotic thoracic operation and a nomenclature to detail the technique used is needed to accurately compare outcomes. METHODS: T ... Full text Link to item Cite

Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve.

Journal Article Development · September 1, 2017 Correct myelination is crucial for the function of the peripheral nervous system. Both positive and negative regulators within the axon and Schwann cell function to ensure the correct onset and progression of myelination during both development and followi ... Full text Link to item Cite

Surgically Managed Clinical Stage IIIA-Clinical N2 Lung Cancer in The Society of Thoracic Surgeons Database.

Journal Article Ann Thorac Surg · August 2017 BACKGROUND: The role of surgical resection in patients with clinical stage IIIA-N2 positive (cIIIA-N2) lung cancer is controversial, partly because of the variability in short- and long-term outcomes. The objective of this study was to characterize the man ... Full text Link to item Cite

Immune profiling of circulating T cells and TILs following neoadjuvant ipilimumab and chemotherapy in non-small cell lung cancer (NSCLC).

Conference Journal of Clinical Oncology · March 1, 2017 26 Background: Ipilimumab (Ipi) is a humanized CTLA-4 antibody that blocks binding of CTLA-4 to B7, permitting T cell activation through CD28. Phased in Ipi added to chemotherapy (C) may enhance efficacy in NSCLC. Methods: Patien ... Full text Cite

Inactivation of ABL kinases suppresses non-small cell lung cancer metastasis.

Journal Article JCI Insight · December 22, 2016 Current therapies to treat non-small cell lung carcinoma (NSCLC) have proven ineffective owing to transient, variable, and incomplete responses. Here we show that ABL kinases, ABL1 and ABL2, promote metastasis of lung cancer cells harboring EGFR or KRAS mu ... Full text Link to item Cite

A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · December 2016 BACKGROUND: The long-term survival benefit of lobectomy over sublobar resection for early-stage non-small cell lung cancer must be weighed against a potentially increased risk of perioperative mortality. The objective of the current study was to create a r ... Full text Link to item Cite

The Society of Thoracic Surgeons General Thoracic Surgery Database: 2016 Update on Research.

Journal Article Ann Thorac Surg · November 2016 The Society of Thoracic Surgeons General Thoracic Surgery Database has grown to more than 500,000 case records. Clinical research supported by the database is increasingly used to advance patient outcomes. This research review from the General Thoracic Sur ... Full text Link to item Cite

Teaching robotic surgery: Making progress.

Journal Article J Thorac Cardiovasc Surg · October 2016 Full text Link to item Cite

Minimally Invasive Versus Open Esophagectomy for Esophageal Cancer: A Population-Based Analysis.

Journal Article Ann Thorac Surg · August 2016 BACKGROUND: The objective of this study was to evaluate outcomes of minimally invasive approaches to esophagectomy using population-level data. METHODS: Multivariable regression modeling was used to determine predictors associated with the use of minimally ... Full text Link to item Cite

Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer.

Journal Article Lung Cancer · August 2016 To determine the feasibility and toxicity of radiation therapy, delivered either as definitive treatment or following surgery, following neo-adjuvant immune checkpoint inhibition for locally advanced NSCLC sixteen patients who received neo-adjuvant chemoth ... Full text Link to item Cite

Long-term survival following open versus thoracoscopic lobectomy after preoperative chemotherapy for non-small cell lung cancer.

Journal Article Eur J Cardiothorac Surg · June 2016 OBJECTIVES: Video-assisted thoracoscopic (VATS) lobectomy is increasingly accepted for the management of early-stage non-small cell lung cancer (NSCLC), but its role for locally advanced cancers has not been as well characterized. We compared outcomes of p ... Full text Link to item Cite

Impact of patient selection and treatment strategies on outcomes after lobectomy for biopsy-proven stage IIIA pN2 non-small cell lung cancer.

Journal Article Eur J Cardiothorac Surg · June 2016 OBJECTIVES: We evaluated the impact of patient selection and treatment strategies on long-term outcomes of patients who had lobectomy after induction therapy for stage IIIA pN2 non-small cell lung cancer (NSCLC). METHODS: The impact of various patient sele ... Full text Link to item Cite

Longitudinal Follow-up of Lung Cancer Resection From the Society of Thoracic Surgeons General Thoracic Surgery Database in Patients 65 Years and Older.

Journal Article Ann Thorac Surg · June 2016 BACKGROUND: The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database (GTSD) does not capture long-term survival after lung cancer surgery. Our objective was to provide longitudinal follow-up to the STS GTSD through linkage to Centers for Me ... Full text Link to item Cite

Role of Adjuvant Therapy in a Population-Based Cohort of Patients With Early-Stage Small-Cell Lung Cancer.

Journal Article J Clin Oncol · April 1, 2016 PURPOSE: Data on optimal adjuvant therapy after complete resection of small-cell lung cancer (SCLC) are limited, and in particular, there have been no studies evaluating the role of adjuvant chemotherapy, with or without prophylactic cranial irradiation, r ... Full text Link to item Cite

Use and Outcomes of Minimally Invasive Lobectomy for Stage I Non-Small Cell Lung Cancer in the National Cancer Data Base.

Journal Article Ann Thorac Surg · March 2016 BACKGROUND: Previous studies have raised concerns that video-assisted thoracoscopic (VATS) lobectomy may compromise nodal evaluation. The advantages or limitations of robotic lobectomy have not been thoroughly evaluated. METHODS: Perioperative outcomes and ... Full text Link to item Cite

Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls.

Journal Article Carcinogenesis · March 2016 Centrosome abnormalities are often observed in premalignant lesions and in situ tumors and have been associated with aneuploidy and tumor development. We investigated the associations of 9354 single-nucleotide polymorphisms (SNPs) in 106 centrosomal genes ... Full text Link to item Cite

Adding radiation to induction chemotherapy does not improve survival of patients with operable clinical N2 non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · December 2015 OBJECTIVE: Radiotherapy is commonly used in induction regimens for patients with non-small cell lung cancer with operable mediastinal nodal disease, although evidence has not shown a benefit over induction chemotherapy alone. We compared outcomes between i ... Full text Link to item Cite

Invited Commentary.

Other Ann Thorac Surg · September 2015 Full text Link to item Cite

Wedge Resection vs Segmentectomy for Patients with T1A N0 Non-Small Cell Lung Cancer

Journal Article JOURNAL OF THORACIC ONCOLOGY · September 1, 2015 Link to item Cite

Right Minithoracotomy Versus Median Sternotomy for Mitral Valve Surgery: A Propensity Matched Study.

Journal Article Ann Thorac Surg · August 2015 BACKGROUND: The efficacy of conventional median sternotomy versus a right minithoracotomy (RT) approach to mitral valve surgery was evaluated in a single high-volume institution. METHODS: A retrospective analysis of a single institution's experience was pe ... Full text Open Access Link to item Cite

Impact of Pulmonary Function Measurements on Long-Term Survival After Lobectomy for Stage I Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · July 2015 BACKGROUND: Pulmonary function tests predict respiratory complications after lobectomy. We evaluated the impact of pulmonary function measurements on long-term survival after lobectomy for stage I non-small cell lung cancer. METHODS: The relationship betwe ... Full text Link to item Cite

Outcomes after treatment of 17,378 patients with locally advanced (T3N0-2) non-small-cell lung cancer.

Journal Article Eur J Cardiothorac Surg · April 2015 OBJECTIVES: Treatment patterns and outcomes in a population-based database were examined to identify patients likely to benefit from surgical resection of locally advanced (T3N0-2) non-small-cell lung cancer (NSCLC). METHODS: Factors predicting the use of ... Full text Link to item Cite

Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition.

Journal Article Cancer research · April 2015 Endothelial-to-mesenchymal transition (EndMT) occurs during development and underlies the pathophysiology of multiple diseases. In tumors, unscheduled EndMT generates cancer-associated myofibroblasts that fuel inflammation and fibrosis, and may contribute ... Full text Cite

Adjuvant chemotherapy after resection of N1 non-small cell lung cancer: differential impact of new evidence on physician and patient decisions.

Journal Article J Thorac Dis · March 2015 BACKGROUND: Adjuvant cisplatin-based chemotherapy (ACT) after resection of stages II-IIIA non-small cell lung cancer (NSCLC) modestly increased survival in several clinical trials. This study evaluated the subsequent impact of those trials on ACT use in cl ... Full text Link to item Cite

The prognostic importance of the number of dissected lymph nodes after induction chemoradiotherapy for esophageal cancer.

Journal Article Ann Thorac Surg · January 2015 BACKGROUND: Analyses of adequacy of lymph node dissection during resection of esophageal cancer are based on patients who have not undergone induction chemoradiotherapy. We sought to determine the minimum number of dissected lymph nodes necessary to ensure ... Full text Link to item Cite

Benign emptying of the postpneumonectomy space.

Journal Article Lung India · 2015 A drop in the air-fluid level in the postpneumonectomy space on a chest radiogram is an early sign of bronchopleural fistula (BPF). Any suspicion of BPF points to the need for urgent evaluation and appropriate management. Very rarely may this drop occur wi ... Full text Link to item Cite

Lung Cancer

Chapter · January 1, 2015 Full text Cite

Quantifying the safety benefits of wedge resection: a society of thoracic surgery database propensity-matched analysis.

Journal Article Ann Thorac Surg · November 2014 BACKGROUND: Wedge resection is often used instead of anatomic resection in an attempt to mitigate perioperative risk. In propensity-matched populations, we sought to compare the perioperative outcomes of patients undergoing wedge resection with those under ... Full text Link to item Cite

The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.

Journal Article Genes Dev · September 1, 2014 Cell type-specific conditional activation of oncogenic K-Ras is a powerful tool for investigating the cell of origin of adenocarcinomas in the mouse lung. Our previous studies showed that K-Ras activation with a CC10(Scgb1a1)-CreER driver leads to adenocar ... Full text Link to item Cite

Induction therapy does not improve survival for clinical stage T2N0 esophageal cancer.

Journal Article J Thorac Oncol · August 2014 INTRODUCTION: This study compared survival after initial treatment with esophagectomy as primary therapy to induction therapy followed by esophagectomy for patients with clinical T2N0 (cT2N0) esophageal cancer in the National Cancer Database (NCDB). METHOD ... Full text Link to item Cite

Thoracoscopic lobectomy is associated with acceptable morbidity and mortality in patients with predicted postoperative forced expiratory volume in 1 second or diffusing capacity for carbon monoxide less than 40% of normal.

Journal Article J Thorac Cardiovasc Surg · July 2014 OBJECTIVE: A predicted postoperative (ppo) forced expiratory volume in 1 second (FEV1%) or diffusing capacity of the lung for carbon monoxide (DLCO%) of <40% has traditionally been considered to convey a high risk of lobectomy owing to elevated postoperati ... Full text Link to item Cite

Robotic benign esophageal procedures.

Journal Article Thorac Surg Clin · May 2014 Robotic master-slave devices can assist surgeons to perform minimally invasive esophageal operations with approaches that have already been demonstrated using laparoscopy and thoracoscopy. Robotic-assisted surgery for benign esophageal disease is described ... Full text Link to item Cite

Minimally invasive and robotic Ivor Lewis esophagectomy.

Journal Article J Thorac Dis · May 2014 Esophageal cancer is the eighth most common malignancy and the sixth most common cause of cancer-related death worldwide. Esophagectomy provides a curative treatment but carries significant morbidity and mortality. Ivor Lewis esophagectomy (ILE) is one of ... Full text Link to item Cite

Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer.

Journal Article Clin Cancer Res · March 15, 2014 PURPOSE: Lung squamous cell carcinoma (LSCC) currently lacks effective targeted therapies. Previous studies reported overexpression of Hedgehog (HH)-GLI signaling components in LSCC. However, they addressed neither the tumor heterogeneity nor the requireme ... Full text Link to item Cite

Survival in the elderly after pneumonectomy for early-stage non-small cell lung cancer: a comparison with nonoperative management.

Journal Article J Am Coll Surg · March 2014 BACKGROUND: Short-term outcomes of morbidity, mortality, and quality of life after pneumonectomy worsen with increasing age. The impact of age on long-term outcomes has not been well described. The purpose of this study was to quantify the impact of patien ... Full text Link to item Cite

Invited commentary.

Other Ann Thorac Surg · November 2013 Full text Link to item Cite

Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells.

Journal Article Cell Stem Cell · March 7, 2013 Sox2 regulates the self-renewal of multiple types of stem cells. Recent studies suggest it also plays oncogenic roles in the formation of squamous carcinoma in several organs, including the esophagus where Sox2 is predominantly expressed in the basal proge ... Full text Link to item Cite

Impact of T status and N status on perioperative outcomes after thoracoscopic lobectomy for lung cancer.

Journal Article J Thorac Cardiovasc Surg · February 2013 OBJECTIVE: We sought to evaluate the effect of tumor size, location, and clinical nodal status on outcomes after thoracoscopic lobectomy for lung cancer. METHODS: All patients who underwent attempted thoracoscopic lobectomy for lung cancer between June 199 ... Full text Link to item Cite

Minithoracotomy versus sternotomy for mitral surgery in patients with chronic renal impairment: a propensity-matched study.

Journal Article Innovations (Phila) · 2013 OBJECTIVE: Compared with median sternotomy, a right thoracotomy (RT) approach to mitral surgery is associated with decreased postoperative acute renal failure. Therefore, we examined propensity-matched patients with chronic renal impairment to compare outc ... Full text Link to item Cite

Cell of origin of lung cancer.

Journal Article J Carcinog · 2013 Lung cancer is the leading cause of cancer deaths worldwide, and current therapies are disappointing. Elucidation of the cell(s) of origin of lung cancer may lead to new therapeutics. In addition, the discovery of putative cancer-initiating cells with stem ... Full text Link to item Cite

Technique of Video-Assisted Thoracoscopic Chest Wall Resection

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · December 1, 2012 Full text Cite

Thoracoscopic lobectomy has increasing benefit in patients with poor pulmonary function: a Society of Thoracic Surgeons Database analysis.

Journal Article Ann Surg · September 2012 OBJECTIVE: Using a national database, we asked whether video-assisted thoracoscopic surgery (VATS) lobectomy is beneficial in high-risk pulmonary patients. BACKGROUND: Single-institution series demonstrated benefit of VATS lobectomy over lobectomy via thor ... Full text Link to item Cite

Lymph node evaluation by open or video-assisted approaches in 11,500 anatomic lung cancer resections.

Journal Article Ann Thorac Surg · August 2012 BACKGROUND: Unsuspected lymph node metastases are found in the surgical specimens of 10% to 25% clinical stage I lung cancers. Video-assisted thoracic surgery (VATS) is a minimally invasive alternative to thoracotomy. Because detection of clinically occult ... Full text Link to item Cite

Self-perceived video-assisted thoracic surgery lobectomy proficiency by recent graduates of North American thoracic residencies.

Journal Article Interact Cardiovasc Thorac Surg · June 2012 Minimally invasive surgical techniques offer several advantages over traditional open procedures, yet the pathway to minimally invasive proficiency can be difficult to navigate. As a part of an effort of the Joint Council of Thoracic Surgical Education to ... Full text Link to item Cite

Outcomes after surgical management of synchronous bilateral primary lung cancers.

Journal Article Ann Thorac Surg · April 2012 BACKGROUND: Distinguishing between synchronous primary lung cancers and metastatic disease in patients with bilateral lung masses is often difficult. The objective of this study is to examine outcomes associated with a strategy of performing staged bilater ... Full text Link to item Cite

Feasibility of hybrid thoracoscopic lobectomy and en-bloc chest wall resection.

Journal Article Eur J Cardiothorac Surg · April 2012 OBJECTIVES: Lobectomy with an en-bloc chest wall resection is an effective but potentially morbid treatment of lung cancer invading the chest wall. Minimally invasive approaches to lobectomy have reduced morbidity compared with thoracotomy for early stage ... Full text Link to item Cite

Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma.

Journal Article Proc Natl Acad Sci U S A · March 27, 2012 Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct junction as a cancer cell of origin when a codon 12 K-Ras mutant is in ... Full text Link to item Cite

Molecular biology of lung cancer

Chapter · January 5, 2012 Cite

Perioperative management of patients on clopidogrel (Plavix) undergoing major lung resection.

Journal Article Ann Thorac Surg · December 2011 BACKGROUND: Management of patients requiring antiplatelet therapy with clopidogrel (Plavix) and major lung resection must balance the risks of bleeding and cardiovascular events. We reviewed our experience with patients treated with clopidogrel perioperati ... Full text Link to item Cite

Persistent N2 disease after neoadjuvant chemotherapy for non-small-cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · November 2011 OBJECTIVES: Patients achieving a mediastinal pathologic complete response with neoadjuvant chemotherapy have improved outcomes compared with patients with persistent N2 disease. How to best manage this latter group of patients is unknown, prompting a revie ... Full text Link to item Cite

Does method of sternal repair influence long-term outcome of postoperative mediastinitis?

Journal Article Am J Surg · November 2011 BACKGROUND: Post-sternotomy mediastinitis reduces survival after cardiac surgery, potentially further affected by details of mediastinal vascularized flap reconstruction. The aim of this study was to evaluate survival after different methods for sternal re ... Full text Link to item Cite

Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle.

Journal Article BMC Med Genomics · October 5, 2011 BACKGROUND: The accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is a major clinical challenge. We developed a model to diagnose IPF by applying Bayesian probit regression (BPR) modelling to gene expression profiles of whole lung tissue. METHODS: ... Full text Link to item Cite

Fundoplication after lung transplantation prevents the allograft dysfunction associated with reflux.

Journal Article Ann Thorac Surg · August 2011 BACKGROUND: Gastroesophageal reflux disease (GERD) in lung recipients is associated with decreased survival and attenuated allograft function. This study evaluates fundoplication in preventing GERD-related allograft dysfunction. METHODS: Prospectively coll ... Full text Link to item Cite

Incorporating research into thoracic surgery practice.

Journal Article Thorac Surg Clin · August 2011 The incorporation of research into a career in thoracic surgery is a complex process. Ideally, the preparation for a career in academic thoracic surgery begins with a research fellowship during training. In the academic setting, a research portfolio might ... Full text Link to item Cite

Efficacy of mediastinal lymph node dissection during lobectomy for lung cancer by thoracoscopy and thoracotomy.

Journal Article Ann Thorac Surg · July 2011 BACKGROUND: Mediastinal lymph node dissection (MLND) is an integral component of complete resection for non-small cell lung cancer (NSCLC). This study analyzed the National Comprehensive Cancer Network's (NCCN) NSCLC Database to compare the efficacy of MLN ... Full text Link to item Cite

Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: Inclusion of a measure of left ventricular diastolic dysfunction (LVDD) may improve risk prediction after cardiac surgery. Current LVDD grading guidelines rely on echocardiographic variables that are not always available or aligned to allow gra ... Full text Link to item Cite

A model for morbidity after lung resection in octogenarians.

Journal Article Eur J Cardiothorac Surg · June 2011 OBJECTIVE: Age is an important risk factor for morbidity after lung resection. This study was performed to identify specific risk factors for complications after lung resection in octogenarians. METHODS: A prospective database containing patients aged 80 y ... Full text Link to item Cite

PERSISTENT N2 DISEASE AFTER NEOADJUVANT CHEMOTHERAPY-NOW WHAT?

Conference JOURNAL OF THORACIC ONCOLOGY · June 1, 2011 Link to item Cite

How well does the new lung cancer staging system predict for local/regional recurrence after surgery?: A comparison of the TNM 6 and 7 systems.

Journal Article J Thorac Oncol · April 2011 INTRODUCTION: To evaluate how well the tumor, node, metastasis (TNM) 6 and TNM 7 staging systems predict rates of local/regional recurrence (LRR) after surgery alone for non-small cell lung cancer. METHODS: All patients who underwent surgery for non-small ... Full text Link to item Cite

A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma.

Journal Article Ann Thorac Surg · April 2011 BACKGROUND: One aspect of the cancer stem cell hypothesis is that patients with tumors that exhibit stem-like phenotypes have poor prognoses. Distal epithelial progenitors from lungs early in development demonstrate both self-renewal and potential to diffe ... Full text Link to item Cite

The role of intrathoracic free flaps for chronic empyema.

Journal Article Ann Thorac Surg · March 2011 BACKGROUND: The management of chronic empyema associated with a bronchopleural fistula can be a particularly challenging problem. Successful eradication may not occur without interposition of healthy vascularized tissue. Pedicled muscle flaps for coverage ... Full text Link to item Cite

Human lung stem cells: has the future arrived?

Journal Article Semin Thorac Cardiovasc Surg · 2011 An intriguing paper was recently published that describes c-kit-positive human lung stem cells that self-renew and differentiate into multiple lineages. While these findings are potentially therapeutically exciting, several questions remain to be answered. ... Full text Link to item Cite

A comprehensive evaluation for aspiration after esophagectomy reduces the incidence of postoperative pneumonia.

Journal Article J Thorac Cardiovasc Surg · December 2010 OBJECTIVE: This study assesses the effect of using a comprehensive swallowing evaluation before starting oral feedings on aspiration detection and pneumonia occurrence after esophagectomy. METHODS: The records of all patients undergoing esophagectomy betwe ... Full text Link to item Cite

Risk factors for atrial fibrillation after lung cancer surgery: analysis of the Society of Thoracic Surgeons general thoracic surgery database.

Journal Article Ann Thorac Surg · August 2010 BACKGROUND: Atrial fibrillation is responsible for significant morbidity after lung cancer surgery, and preoperative and perioperative risk factors are not well described. METHODS: The Society of Thoracic Surgeons (STS) database was queried for all lobecto ... Full text Link to item Cite

Invited commentary.

Other Ann Thorac Surg · July 2010 Full text Link to item Cite

Evidence that SOX2 overexpression is oncogenic in the lung.

Journal Article PLoS One · June 10, 2010 BACKGROUND: SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung. METHODOLOGY/PRINCIPAL FINDINGS: We show that SOX2 is overexpressed in human squamous cell ... Full text Open Access Link to item Cite

Pulmonary function tests do not predict pulmonary complications after thoracoscopic lobectomy.

Journal Article Ann Thorac Surg · April 2010 BACKGROUND: Pulmonary function tests predict respiratory complications and mortality after lung resection through thoracotomy. We sought to determine the impact of pulmonary function tests upon complications after thoracoscopic lobectomy. METHODS: A model ... Full text Link to item Cite

Thoracoscopic lobectomy is associated with lower morbidity than open lobectomy: a propensity-matched analysis from the STS database.

Journal Article J Thorac Cardiovasc Surg · February 2010 BACKGROUND: Several single-institution series have demonstrated that compared with open thoracotomy, video-assisted thoracoscopic lobectomy may be associated with fewer postoperative complications. In the absence of randomized trials, we queried the Societ ... Full text Link to item Cite

Outcomes of video-assisted thoracoscopic decortication.

Journal Article Ann Thorac Surg · January 2010 BACKGROUND: Video-assisted thoracoscopic surgical decortication (VATSD) is widely used for treatment of early empyema and hemothorax, but conversion to open thoracotomy for decortication (OD) is more frequent in the setting of complex, chronic empyema. Thi ... Full text Link to item Cite

Characterizing the clinical relevance of an embryonic stem cell phenotype in lung adenocarcinoma.

Journal Article Clin Cancer Res · December 15, 2009 PURPOSE: Cancer cells possess traits reminiscent of those ascribed to normal stem cells. It is unclear whether these phenotypic similarities are the result of a common biological phenotype, such as regulatory pathways. EXPERIMENTAL DESIGN: Lung cancer cell ... Full text Link to item Cite

Risk factors for morbidity after lobectomy for lung cancer in elderly patients.

Journal Article Ann Thorac Surg · October 2009 BACKGROUND: Studies evaluating risk factors for complications after lobectomy in elderly patients have not adequately analyzed the effect of using minimally invasive approaches. METHODS: A model for morbidity including published preoperative risk factors a ... Full text Link to item Cite

Basal cells as stem cells of the mouse trachea and human airway epithelium.

Journal Article Proc Natl Acad Sci U S A · August 4, 2009 The pseudostratified epithelium of the mouse trachea and human airways contains a population of basal cells expressing Trp-63 (p63) and cytokeratins 5 (Krt5) and Krt14. Using a KRT5-CreER(T2) transgenic mouse line for lineage tracing, we show that basal ce ... Full text Link to item Cite

Thoracoscopic lobectomy is associated with lower morbidity compared with thoracotomy.

Journal Article J Thorac Cardiovasc Surg · August 2009 OBJECTIVES: Advantages of thoracoscopic lobectomy include less postoperative pain, shorter hospitalization, and improved delivery of adjuvant chemotherapy. The incidence of postoperative complications has not been thoroughly assessed. This study analyzes m ... Full text Link to item Cite

Smoking cessation and the success of lung cancer surgery.

Journal Article Curr Oncol Rep · July 2009 Lung cancer is the number one cause of cancer-related mortality in the United States. Cigarette smoke is associated with 90% of lung cancer deaths, making it the most important risk factor for the disease. The strong correlation between smoking and lung ca ... Full text Link to item Cite

Prognostic factors for recurrence after pulmonary resection of colorectal cancer metastases.

Journal Article Ann Thorac Surg · June 2009 BACKGROUND: This study was undertaken to review a large series of resections of colorectal pulmonary metastases in the era of modern chemotherapy. METHODS: A retrospective chart review of prospectively maintained thoracic surgery databases identified 378 p ... Full text Link to item Cite

Basal cells in lung cancer

Conference Journal of the American College of Surgeons · September 2008 Full text Cite

Factors influencing outcome after pulmonary resection for colorectal cancer (CRC) metastases in the current era.

Journal Article J Clin Oncol · May 20, 2008 4024 Background: We examined the role for surgery and factors associated with relapse-free and overall survival after pulmonary metastasectomy for CRC. METHODS: A retrospective review of prospective databases at two tertiary-care centers was performed to i ... Link to item Cite

Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patients.

Journal Article Ann Surg · September 2006 OBJECTIVE: Advantages of thoracoscopic lobectomy for early stage non-small cell lung cancer (NSCLC), as compared with lobectomy by conventional thoracotomy, include less postoperative pain and shorter length of hospitalization. The outcomes after thoracosc ... Full text Link to item Cite

The Kraske procedure: a critical analysis of a surgical approach for mid-rectal lesions.

Journal Article J Surg Oncol · September 1, 2006 BACKGROUND AND OBJECTIVES: To analyze the Kraske procedure as an approach to mid-rectal disease. METHODS: Twenty-two patients underwent a Kraske procedure at either Duke University Medical Center, the Durham Veterans Administration Medical Center, or the D ... Full text Link to item Cite

Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor response.

Journal Article Arch Surg · November 2005 HYPOTHESIS: Analysis of multiple clinical and pathological factors in patients undergoing therapeutic hyperthermic isolated limb perfusion for extremity melanoma can identify variables with prognostic significance. DESIGN: Retrospective review of a prospec ... Full text Link to item Cite

Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses.

Journal Article J Surg Res · April 2005 BACKGROUND: Cotransfection of dendritic cells (DC) with MART-1 and constitutively active TLR4 (caTLR4) RNA enhances the maturation of DC. MATERIALS AND METHODS: Immature DC were cotransfected with RNA constructs encoding MART-1 and caTLR4, and CTL response ... Full text Link to item Cite

Iodine-131 metaiodobenzylguanidine treatment for metastatic carcinoid. Results in 98 patients.

Journal Article Cancer · November 1, 2004 BACKGROUND: Iodine-131 metaiodobenzylguanidine (131I-MIBG) is useful for imaging carcinoid tumors and recently has been applied to the palliative treatment of metastatic carcinoid in small studies. The authors now report their results on the therapeutic ut ... Full text Link to item Cite

Pancreatic duct strictures: identifying risk of malignancy.

Journal Article Ann Surg Oncol · June 2004 BACKGROUND: This study aimed to define PDS characteristics that predict malignancy and would thus invoke further diagnostic evaluation or aggressive treatment. METHODS: 355 cases of PDS were diagnosed by ERCP during a 7-year period at a single institution. ... Full text Link to item Cite

Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cells.

Journal Article J Gastrointest Surg · February 2004 RNA-based dendritic cell immunotherapy with the use of total tumor RNA provides the potential to generate a polyclonal immune response to multiple known and unknown tumor antigens without HLA restriction. Our study evaluated this approach as potential immu ... Full text Link to item Cite

Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity.

Journal Article J Surg Res · January 2004 BACKGROUND: Despite the increasing use of dendritic cells (DCs) in clinical trials, questions regarding the optimal means of DC preparation, in particular how to achieve optimal maturation, remain unanswered. We hypothesized that delivering two separate se ... Full text Link to item Cite

CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy.

Journal Article Surgery · August 2003 BACKGROUND: Dendritic cell (DC)-based immunotherapy is a promising form of adjuvant therapy for high-risk tumors. DCs transfected with tumor-associated antigens are capable of stimulating antigen-specific T cells, but cytolytic responses have been disappoi ... Full text Link to item Cite

Adjuvant hepatic arterial chemotherapy following metastasectomy in patients with isolated liver metastases.

Journal Article Ann Surg · June 2003 OBJECTIVE: To examine survival and toxicity by querying a single-institutional experience with adjuvant hepatic arterial infusional (HAI) chemotherapy. SUMMARY BACKGROUND DATA: Three randomized series in the literature have examined adjuvant HAI after comp ... Full text Link to item Cite

Carcinoid tumors of the gastrointestinal tract. A review and the Duke University institutional overview.

Journal Article Minerva Chir · February 2003 Carcinoid tumors are relatively rare neoplasms arising from the amine precursor uptake and decarboxylation (APUD) cells of the gastrointestinal tract and bronchial tree. Presenting symptoms vary by site of origin, and various modalities may be used to diag ... Link to item Cite

Thoracoscopic lobectomy: a safe and effective strategy for patients with stage I lung cancer.

Journal Article Ann Thorac Surg · September 2002 BACKGROUND: Thoracoscopic lobectomy is emerging as a potential alternative to thoracotomy for early stage lung cancer. The issues of safety and oncologic efficacy should be analyzed before recommending this procedure for widespread use. METHODS: Thoracosco ... Full text Link to item Cite

Dendritic cell gene therapy.

Journal Article Surg Oncol Clin N Am · July 2002 All of these studies taken together highlight key areas that must be addressed in the future in order for the field to continue to move forward. These issues are many, including but not limited to method of delivery of dendritic cells to patients, maturati ... Full text Link to item Cite

Enhanced dendritic cell antigen presentation in RNA-based immunotherapy.

Journal Article J Surg Res · June 1, 2002 BACKGROUND: Dendritic cells pulsed with mRNA provide a unique approach to tumor immunotherapy. We hypothesized that increased mRNA transfection efficiency and dendritic cell maturation would improve antigen processing and presentation as well as T-cell cos ... Full text Link to item Cite

Carcinoid and chylous ascites: an unusual association.

Journal Article J Gastrointest Surg · 2002 Chylous ascites caused by carcinoid tumors is extremely rare. While carcinoid tumors usually have an indolent course, their association with chylous ascites is a harbinger of a poor outcome. ... Full text Link to item Cite

Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival.

Journal Article Ann Surg Oncol · December 2001 BACKGROUND: Up to 30% of patients with locally advanced rectal cancer have a complete clinical or pathologic response to neoadjuvant chemoradiation. This study analyzes complete clinical and pathologic responders among a large group of rectal cancer patien ... Full text Link to item Cite

Gastrointestinal carcinoids: characterization by site of origin and hormone production.

Journal Article Ann Surg · October 2000 OBJECTIVE: To describe a large series of patients with carcinoid tumors in terms of presenting symptoms, hormonal data, stage at diagnosis, pathologic features, and survival. SUMMARY BACKGROUND DATA: Published series have described significant prognostic f ... Full text Link to item Cite

Foregut carcinoids: a clinical and biochemical analysis.

Journal Article Surgery · December 1999 BACKGROUND: Gastrointestinal foregut carcinoids make up a small percentage (3% to 6%) of all reported carcinoids. Because these tumors are so uncommon, comparisons between the subtypes have been difficult. The goal of this study was to compare the hormonal ... Full text Link to item Cite

Carcinoids of unknown origin: comparative analysis with foregut, midgut, and hindgut carcinoids.

Journal Article Surgery · December 1998 BACKGROUND: Carcinoids are rare neuroendocrine tumors typically arising in the gastrointestinal tract. A significant percentage of these tumors present as metastatic disease of unknown primary site. The aim of this study was to better define the functional ... Full text Link to item Cite