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Matthew Hartwig

Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery
Box 3863 Med Ctr, Durham, NC 27710
DUMC 3863, Durham, NC 27710

Selected Grants


US National OCS Lung Thoracic Organ Perfusion (TOP) Registry

Clinical TrialPrincipal Investigator · Awarded by TransMedics · 2024 - 2034

The Post-Lung Transplant Impact of Alveolar Macrophage Senescence in Aged Donor Lungs

ResearchAdvisor · Awarded by National Institutes of Health · 2025 - 2030

2/3 CTSA K12 Program at Duke University

ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030

Optimizing Donor Management in Lung Transplantation

ResearchPrincipal Investigator · Awarded by Washington University in St. Louis · 2025 - 2030

The Role of Tacrolimus, TGF-ss, and the inflammatory/regulatory balance in CLAD development

FellowshipPrincipal Investigator · Awarded by Thoracic Surgery Foundation for Research and Education · 2026 - 2028

Lung Transplant Clinical Trial Network (LT-CTN)

ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2028

Clinical and Mechanistic Factors Impacting Transplant Outcomes (U01)

ResearchCo-Principal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2027

Cystic Fibrosis Lung Transplant Consortium

ResearchCo Investigator · Awarded by Cystic Fibrosis Foundation · 2020 - 2026

BMI Service Agreement

ResearchPrincipal Investigator · Awarded by BioMedInnovations, LLC · 2021 - 2026

PROTOCOL PGX-004 OBSERVATIONAL STUDY OF LUNG PRESERVATION

Clinical TrialPrincipal Investigator · Awarded by Paragonix · 2021 - 2026

Targeting Inflammation and Alloimmunity in Lung Transplant Recipients With Clazakizumab

Clinical TrialPrincipal Investigator · Awarded by Massachusetts General Hospital · 2021 - 2026

Creation of a Data Asset to Identify Barriers in Access to Lung Transplant

ResearchCo-Principal Investigator · Awarded by Cystic Fibrosis Foundation · 2025 - 2026

CRA+ Planning Grant for Allo-islet Cell Transplantation in Lung Transplant Recipients with Insulin Resistance

ResearchPrincipal Investigator · Awarded by Cystic Fibrosis Foundation · 2024 - 2026

Cystic Fibrosis Foundation Lung Transplant Initiative: Surgeons Committee

Institutional SupportPrincipal Investigator · Awarded by Cystic Fibrosis Foundation · 2022 - 2025

Perpetual Organ Preservation and Rehabilitation (POPR)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025

Objective Lung Assessment Tools For Improved Organ Use In Lung Transplantation

ResearchPrincipal Investigator · Awarded by University of Pennsylvania · 2021 - 2025

Adeno-Associated Vector based PD-L1 Transgene Expression to Attenuate Acute Cellular Rejection in a Murine Lung Transplant Model

FellowshipPrincipal Investigator · Awarded by Cystic Fibrosis Foundation · 2024 - 2025

Student Traineeship Award

FellowshipPrincipal Investigator · Awarded by Cystic Fibrosis Foundation · 2023 - 2024

Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

Increasing Lung Transplant Availability Using Normothermic Ex Vivo Lung Perfusion (EVLP) at a Dedicated EVLP Facility

Clinical TrialPrincipal Investigator · Awarded by Lung Bioengineering, Inc. · 2019 - 2024

PFC's in ARDS

ResearchPrincipal Investigator · Awarded by Boundless Science · 2022 - 2024

TSF Resident Research Fellowship

ResearchPrincipal Investigator · Awarded by Thoracic Surgery Foundation for Research and Education · 2022 - 2023

TransMedics Lungs for Transplantation EXPAND II Trial

Clinical TrialPrincipal Investigator · Awarded by TransMedics · 2018 - 2023

FSF Fellowship

FellowshipPrincipal Investigator · Awarded by Foundation for Surgical Fellowships · 2021 - 2022

Expand Trial

Clinical TrialPrincipal Investigator · Awarded by TransMedics · 2016 - 2022

Retrospective Lobectomy

Clinical TrialPrincipal Investigator · Awarded by Intuitive Surgical, Inc. · 2017 - 2021

Polarean - POL-Xe-002 Study

Clinical TrialPrincipal Investigator · Awarded by Polarean Imaging plc · 2018 - 2021

LINX After Lung Transplantation

ResearchPrincipal Investigator · Awarded by Torax Medical Inc. · 2017 - 2021

Polarean - POL-XE-001 Study

Clinical TrialPrincipal Investigator · Awarded by Polarean Imaging plc · 2018 - 2021

A Phase 2, Multicenter, Open Label Study To Measure Safety Donor Lungs (EVLP)

Clinical TrialPrincipal Investigator · Awarded by Lung Bioengineering, Inc. · 2017 - 2021

Cystic Fibrosis Lung Transplant Consortium

ResearchCo Investigator · Awarded by Cystic Fibrosis Foundation Therapeutics, Inc. · 2017 - 2019

ExVivo Lung Study ¿ Biocompatibility Assessment of ExVivo Disposable Perfusion Kit with Nitric Oxide and/or MP3964

ResearchPrincipal Investigator · Awarded by Mallinckrodt Pharmaceuticals · 2019 - 2019

Clinical Risk Factors for Primary Graft Dysfunction

ResearchPrincipal Investigator · Awarded by University of Pennsylvania · 2015 - 2018

FSF Fellowship

FellowshipPrincipal Investigator · Awarded by Foundation for Surgical Fellowships · 2016 - 2017

Obesity, Inflammation, and Lung Injury after Lung Transplantation

ResearchCo Investigator · Awarded by Columbia University · 2013 - 2017

Prospective Registry of Outcomes in Patients Electing Lung Transplantation (PROPEL)

Clinical TrialPrincipal Investigator · Awarded by University of Pennsylvania · 2014 - 2016

More and Better Lungs: Ex-Vivo Perfusion of Non-Heart-Beating Donors?

ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2014 - 2016

External Relationships


  • Biomedinnovations
  • CSL Behring AG
  • Intuitive Surgical, Inc.
  • Paragonix
  • Transmedics

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.