Scholars@Duke
Matthew Hartwig

Matthew Hartwig

Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery
matthew.hartwig@duke.edu
Box 3863 Med Ctr, Durham, NC 27710
DUMC 3863, Durham, NC 27710

Selected Publications

Lung transplantation from donation after circulatory death donors over 55 years old: A national analysis of outcomes and utilization.

Journal Article JHLT Open · February 2026 BACKGROUND: Lungs from older donation after circulatory death (DCD) donors are underutilized; however, these organs may represent an opportunity to expand the donor pool. Herein, we evaluated utilization and outcomes of lung transplants using lungs from ol ... Full text Open Access Link to item Cite

Combined heart-lung organ allocation: A glitch in the system.

Journal Article J Heart Lung Transplant · December 2025 Organ allocation guidelines prioritize patients at risk of waitlist mortality. In the United States, both the heart and lung allocation systems were revised within the last ten years. There is no specific allocation system for patients listed for combined ... Full text Link to item Cite

Outcomes of central versus peripheral arterial cannulation for intraoperative extracorporeal membrane oxygenation support in lung transplantation.

Journal Article J Heart Lung Transplant · October 8, 2025 BACKGROUND: Intraoperative venoarterial extracorporeal membrane oxygenation (VA ECMO) is becoming the most common mode of extracorporeal life support (ECLS) in lung transplantation (LTx). We compared rates of primary graft dysfunction (PGD) and other perio ... Full text Link to item Cite

Impact of Antireflux Surgery on Interstitial Lung Disease and Lung Transplantation

Journal Article Foregut: The Journal of the American Foregut Society · October 6, 2025 Gastroesophageal reflux disease (GERD) is a prevalent problem in patients with interstitial lung disease (ILD) before or after lung transplantation. It has been linked to the pathogenesis of ILD, but the precise nature of this relationship remains ... Full text Cite

The short end of the stick: Access to lung transplantation for short-statured patients in the composite allocation score era.

Journal Article Am J Transplant · October 2025 Short-statured lung transplant candidates experience longer waitlist times than taller ones. The new composite allocation score (CAS) includes height to enhance allocation equity. We assessed the impact of CAS on waitlist outcomes for different height grou ... Full text Link to item Cite

Adeno-associated virus-mediated transduction of PD-L1 in a rodent lung transplant model.

Journal Article Am J Transplant · October 2025 Acute cellular rejection is a key contributor to chronic lung allograft dysfunction following transplantation; while treatable, traditional immunosuppressive therapies are associated with significant side effects. Gene therapy offers an approach to modulat ... Full text Link to item Cite

A Case of Selection, Not Superiority.

Journal Article Ann Thorac Surg · October 2025 Full text Link to item Cite

Dual ex vivo lung perfusion via pulmonary and bronchial arteries in a porcine model.

Conference JTCVS Tech · October 2025 BACKGROUND: Current clinical ex vivo lung perfusion (EVLP) perfuses the pulmonary arteries (PA) but not the bronchial arteries (BA) that normally supply the upper airway. We hypothesized that the PA alone do not fully perfuse this region during EVLP, which ... Full text Link to item Cite

Assessing blood culture appropriateness in solid organ transplant recipients: a diagnostic stewardship approach.

Journal Article Infect Control Hosp Epidemiol · September 29, 2025 OBJECTIVE: Diagnostic stewardship of blood culture utilization is important to mitigate the risks associated with unnecessary culturing. Although blood culture algorithms have been studied previously, there is a lack of data on their application among soli ... Full text Link to item Cite

Allocation Out of Sequence in Lung Transplant: An Analysis of the UNOS Registry.

Journal Article JAMA Surg · September 1, 2025 IMPORTANCE: Allocation out of sequence (AOOS) allows organ procurement organizations (OPOs) to offer organs outside of standard allocation and bypass those atop the match run. AOOS may allow OPOs to successfully place medically complex organs; however, inc ... Full text Open Access Link to item Cite

Donor and recipient factors associated with primary graft dysfunction following lung transplantation: A donor management goal registry analysis.

Conference J Thorac Cardiovasc Surg · August 2025 BACKGROUND: Current risk-adjusted models for predicting primary graft dysfunction (PGD) following lung transplantation (LTx) do not include bedside donor critical care data. Donor management goals (DMGs) represent predefined critical care endpoints aimed a ... Full text Link to item Cite

Clinical and System-Level Factors Driving Donor Lung Utilization Decisions: A Qualitative Study.

Journal Article Ann Am Thorac Soc · August 2025 Rationale: Key knowledge gaps exist in understanding what drives donor utilization decisions and contributes to the significant variability in organ offer acceptance rates. Defining and addressing the factors that explain variability in organ offer accepta ... Full text Link to item Cite

Sizing in lung transplantation: principles, practices and ideas for the future.

Journal Article JHLT Open · August 2025 Lung transplantation (LTx) is an important treatment option for many end-stage lung diseases. The goal of LTx is to restore pulmonary physiology (gas exchange and respiratory system mechanics) towards normal, so that LTx recipients can experience an improv ... Full text Link to item Cite

Delayed Extrusion of Hydroxyapatite Cement Orbital Floor Implant: A Rare Case Report of Augmentation Failure

Journal Article Case Reports in Ophthalmology · July 28, 2025 <p>Introduction: Hydroxyapatite implants are widely used in orbital reconstruction due to their biocompatibility and capacity for osseointegration. Complications such as implant exposure or extrusion typically occur in the early postoperative ... Full text Cite

Robotic-assisted single-port system for pulmonary lobectomy: A prospective feasibility study.

Journal Article J Thorac Cardiovasc Surg · July 2025 OBJECTIVE: To confirm the feasibility and safety of the da Vinci single-port (SP) System to perform pulmonary lobectomy procedures using a subcostal, uniportal approach. METHODS: A prospective multicenter, single-arm clinical study evaluating the performan ... Full text Link to item Cite

Long-term outcomes of the international EXPAND trial of Organ Care System (OCS) Lung preservation for lung transplantation.

Journal Article EClinicalMedicine · July 2025 BACKGROUND: Portable ex vivo lung perfusion and ventilation with the Organ Care System (OCS) Lung system is a safe, effective method for preserving extended criteria donor (ECD) organs before transplant. Although this technology is increasingly used in the ... Full text Link to item Cite

Initial Evaluation of the Safety and Performance of Single-Port Robotic-Assisted Thymectomy Through a Subxiphoid Incision.

Journal Article Ann Thorac Surg · May 2025 BACKGROUND: Sternotomy is the traditional approach for thymectomy. However, over the last 2 decades, minimally invasive surgical approaches (multiport thoracoscopic and robotic-assisted surgery) have proven feasible, offering similar survival, lower morbid ... Full text Link to item Cite

Outcomes of lung transplantation from SARS-CoV-2 positive donors during the Omicron wave.

Journal Article JHLT Open · May 2025 Early observations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission via lung transplantation have led to frequent discard of lungs from donors with positive SARS-CoV-2 tests. We compared survival between lung transplant recipien ... Full text Link to item Cite

Use of a novel donor lung scoring system as a tool for increasing lung recovery for transplantation.

Conference J Thorac Cardiovasc Surg · April 2025 BACKGROUND: There is a critical shortage of donor lungs for transplantation. We previously developed a parsimonious, highly discriminatory 9-variable Lung Donor (LUNDON) acceptability score. Here we assessed the utility of this score as a tool for improvin ... Full text Link to item Cite

Predictors of donation after circulatory death lung utilization and allograft survival.

Journal Article J Heart Lung Transplant · April 2025 BACKGROUND: Understanding donor factors associated with successful lung transplantation (LTx) following donation after circulatory death (DCD) is important in optimizing donor management. In this study, we examined critical care and ventilatory factors ass ... Full text Link to item Cite

Perioperative Bleeding Risk in Lung Transplantation After Previous Cardiothoracic Surgery.

Journal Article Clin Transplant · April 2025 INTRODUCTION: Previous cardiothoracic surgery (CTS) is associated with a significant risk of perioperative bleeding in lung transplantation (LT). The types of prior surgery have not been well-defined. We aimed to quantify the risk of perioperative bleeding ... Full text Link to item Cite

Factors associated with waitlist clinical deterioration among United States lung transplant recipients under the continuous distribution system.

Journal Article J Heart Lung Transplant · March 2025 BACKGROUND: Lung continuous distribution (CD), implemented on March 9, 2023, changed the calculation and relative importance of medical urgency and post-transplant survival in prioritizing candidates for transplant. We aimed to identify factors associated ... Full text Link to item Cite

Thoracoabdominal Normothermic Regional Perfusion and Donation After Circulatory Death Lung Use.

Journal Article JAMA Netw Open · February 3, 2025 IMPORTANCE: Donation after circulatory death (DCD) heart procurement has increased, but concerns remain about the effect of simultaneous heart and lung procurement, particularly with thoracoabdominal normothermic regional perfusion (TA-NRP), on the use of ... Full text Link to item Cite

Longitudinal Follow-up of Medicare Patients After Esophageal Cancer Resection in the STS Database.

Journal Article Ann Thorac Surg · February 2025 BACKGROUND: Understanding characteristics associated with survival after esophagectomy for cancer is critical to preoperative risk stratification. This study sought to define predictors for long-term survival after esophagectomy for cancer in Medicare pati ... Full text Link to item Cite

The 2024 American Association for Thoracic Surgery expert consensus document: Current standards in donor lung procurement and preservation.

Journal Article J Thorac Cardiovasc Surg · February 2025 BACKGROUND: Donor lung procurement and preservation is critical for lung transplantation success. Unfortunately, the large variability in techniques impacts organ utilization rates and transplantation outcomes. Compounding this variation, recent developmen ... Full text Link to item Cite

Surgeons are apprehensive to use DCD lungs despite similar post-transplant outcomes: A 20-year UNOS retrospective analysis.

Journal Article JHLT Open · February 2025 PURPOSE: As rates of lung transplants in the US grow, waitlist mortality increases. While the literature reports similar survival outcomes of DBD and DCD transplants, research should investigate improvements to DCD lung recovery protocols to increase the t ... Full text Link to item Cite

The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study.

Journal Article Anesth Analg · January 1, 2025 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Link to item Cite

Ex vivo lung perfusion: recent advancements and future directions.

Journal Article Front Immunol · 2025 Ex-vivo lung perfusion (EVLP) has emerged as a transformative technique in lung transplantation, offering a solution for evaluating and rehabilitating donor lungs that would otherwise be deemed unsuitable. This review article examines the significant advan ... Full text Link to item Cite

Left Atrial Appendage Ligation to Prevent Post Lung Transplant Cerebrovascular Accidents

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2025 Cite

Impact of COVID-19 on Lung Transplant Patients: A Multi-Center Clinical Study

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2025 Cite

A multicenter analysis of lung transplantation outcomes comparing donation after circulatory death and donation after brain death.

Journal Article JHLT Open · November 2024 BACKGROUND: Donor organ shortage is a barrier to lung transplantation. Donation after circulatory death (DCD) may offer a solution, although it is underutilized. The objective of this study was to compare survival and other postoperative outcomes between D ... Full text Open Access Link to item Cite

Textbook Outcomes in Solid Transplantation: A Systematic Review.

Journal Article Transplant Direct · October 2024 BACKGROUND: The concept of TO is expanding across various surgical disciplines to establish a standardized, comprehensive quality benchmark. Traditional metrics such as 1-y patient and graft survival have been key for evaluating transplant program performa ... Full text Link to item Cite

The Society of Thoracic Surgeons Database Analysis: Comparing Sublobar Techniques in Stage IA Lung Cancer.

Journal Article Ann Thorac Surg · September 2024 BACKGROUND: This study compares sublobar resections-wedge resection and segmentectomy-in clinical stage IA lung cancers. It tests the hypothesis that overall survival after wedge resection is similar to segmentectomy. METHODS: Adults undergoing wedge resec ... Full text Link to item Cite

Ex vivo lung perfusion in donation after circulatory death: A post hoc analysis of the Normothermic Ex Vivo Lung Perfusion as an Assessment of Extended/Marginal Donors Lungs trial.

Journal Article J Thorac Cardiovasc Surg · September 2024 OBJECTIVE: Donation after circulatory death (DCD) donors offer the ability to expand the lung donor pool and ex vivo lung perfusion (EVLP) further contributes to this ability by allowing for additional evaluation and resuscitation of these extended criteri ... Full text Link to item Cite

A Multi-Center International Analysis of Lung Transplantation Outcomes in Patients With COVID-19.

Journal Article Clin Transplant · September 2024 INTRODUCTION: Lung transplantation has become increasingly utilized in patients with COVID-19. While several single-center and UNOS database studies have been published on lung transplants (LTs) for end-stage lung disease (ESLD) from Coronavirus disease 20 ... Full text Open Access Link to item Cite

Optimizing DCD Liver Grafts With Prolonged Warm Ischemic Time Using Stabilized Plasmin in a Static Cold Storage Orthotopic Rat Liver Transplant Model.

Journal Article Transplant Direct · August 2024 BACKGROUND: The clinical success of liver transplantation has led to increased demand, requiring further expansion of the donor pool. Therapeutic interventions to optimize organs from donation after circulatory death (DCD) have significant potential to mit ... Full text Link to item Cite

Consensus Statement: Technical Standards for Thoracoabdominal Normothermic Regional Perfusion.

Journal Article Transplantation · August 1, 2024 BACKGROUND: Thoracoabdominal normothermic regional perfusion (TA-NRP) has emerged as a powerful technique for optimizing organ procurement from donation after circulatory death donors. Despite its rapid adoption, standardized guidelines for TA-NRP implemen ... Full text Link to item Cite

With Comparable Outcomes, Should Early-Stage Lung Cancer Be a Contraindication to Lung Transplant?

Journal Article Ann Thorac Surg · July 2024 BACKGROUND: Active primary lung malignancy remains a strong contraindication to lung transplantation (LTx). However, outcomes are unclear for patients with early-stage non-small cell lung cancer (NSCLC) who undergo LTx. We hypothesize that patients with ea ... Full text Link to item Cite

Validation of a novel donor lung scoring system based on the updated lung Composite Allocation Score.

Journal Article Am J Transplant · July 2024 Lung transplantation (LTx) continues to have lower rates of long-term graft survival compared with other organs. Additionally, lung utilization rates from brain-dead donors remain substantially lower compared with other solid organs, despite a growing need ... Full text Link to item Cite

Knowledge gaps in heart and lung donation after the circulatory determination of death: Report of a workshop of the National Heart, Lung, and Blood Institute.

Journal Article J Heart Lung Transplant · June 2024 In a workshop sponsored by the U.S. National Heart, Lung, and Blood Institute, experts identified current knowledge gaps and research opportunities in the scientific, conceptual, and ethical understanding of organ donation after the circulatory determinati ... Full text Link to item Cite

Subnormothermic Oxygenated Machine Perfusion (24 h) in DCD Kidney Transplantation.

Journal Article Transplant Direct · June 2024 BACKGROUND: Ex vivo kidney perfusion is an evolving platform that demonstrates promise in preserving and rehabilitating the kidney grafts. Despite this, there is little consensus on the optimal perfusion conditions. Hypothermic perfusion offers limited fun ... Full text Link to item Cite

Gene delivery followed by ex vivo lung perfusion using an adeno-associated viral vector in a rodent lung transplant model.

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVE: Ex vivo lung perfusion has emerged as a platform for organ preservation, evaluation, and restoration. Gene delivery using a clinically relevant adeno-associated vector during ex vivo lung perfusion may be useful in optimizing donor allografts wh ... Full text Link to item Cite

Short-term outcomes after third-time lung transplantation: A single institution experience.

Journal Article J Heart Lung Transplant · May 2024 BACKGROUND: Reoperative lung transplantation (LTx) survival has improved over time such that a growing number of patients may present for third-time LTx (L3Tx). To understand the safety of L3Tx, we evaluated perioperative outcomes and 3-year survival after ... Full text Link to item Cite

Efforts to improve the billing accuracy of robotic-assisted thoracic surgery through education, updated procedure cards, and electronic medical record system changes.

Journal Article BMJ Open Qual · April 22, 2024 Precise medical billing is essential for decreasing hospital liability, upholding environmental stewardship and ensuring fair costs for patients. We instituted a multifaceted approach to improve the billing accuracy of our robotic-assisted thoracic surgery ... Full text Link to item Cite

Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates.

Journal Article J Heart Lung Transplant · April 2024 BACKGROUND: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Accurate prediction of PGD risk could inform donor approaches and perioperative care planning. We sought to develop a clinically u ... Full text Link to item Cite

The cost of lung transplantation in the United States: How high is too high?

Journal Article JTCVS Open · April 2024 OBJECTIVES: To identify patient and process factors that contribute to the high cost of lung transplantation (LTx) in the perioperative period, which may allow transplant centers to evaluate situations in which transplantation is most cost-effective to inf ... Full text Link to item Cite

Computed Tomography Volumetrics for Size Matching in Lung Transplantation for Restrictive Disease.

Journal Article Ann Thorac Surg · February 2024 BACKGROUND: There is no consensus on the optimal allograft sizing strategy for lung transplantation in restrictive lung disease. Current methods that are based on predicted total lung capacity (pTLC) ratios do not account for the diminutive recipient chest ... Full text Link to item Cite

Impact of Diabetes on Pathologic Response to Multimodality Therapy for Esophageal Cancer.

Journal Article Ann Thorac Surg · January 2024 BACKGROUND: The incidence of esophageal cancer has increased faster than that of most cancers. Evidence from other malignant neoplasms suggests that diabetic patients have a worse response to multimodality therapy. We hypothesized that diabetic patients wi ... Full text Link to item Cite

Commentary: Who should be using ex vivo lung perfusion?

Journal Article J Thorac Cardiovasc Surg · January 2024 Full text Link to item Cite

Impact of simultaneous heart procurement on outcomes of donation after circulatory death lung transplantation.

Journal Article Am J Transplant · January 2024 Donation after circulatory death (DCD) heart procurement is done using either direct procurement (DP) or thoracoabdominal normothermic machine perfusion (TA-NRP). Both approaches could impact lung transplant outcomes with combined heart and lung procuremen ... Full text Link to item Cite

The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.

Journal Article Am J Respir Crit Care Med · January 1, 2024 Rationale: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Prior studies implicated proxy-defined donor smoking as a risk factor for PGD and mortality. Objectives: We aimed to more accuratel ... Full text Link to item Cite

5-Year Outcomes of the Organ Care System (OCS) Lung EXPAND Pivotal International Trial

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2024 Cite

A call to action in thoracic transplant surgical training.

Journal Article J Heart Lung Transplant · November 2023 Thoracic organ recovery and implantation is increasing in complexity. Simultaneously the logistic burden and associated cost is rising. An electronic survey distributed to the surgical directors of thoracic transplant programs in the United States indicate ... Full text Link to item Cite

Real-world Experiences in the Transplantation of Hepatitis C-NAAT-positive Organs.

Journal Article Transplant Direct · November 2023 BACKGROUND: Hepatitis C virus (HCV) nucleic acid amplification test (NAAT)-positive donors have increased the organ pool. Direct-acting antivirals (DAAs) have led to high rates of treatment success and sustained virologic response (SVR) in recipients with ... Full text Link to item Cite

Development of New Donor-Specific and Human Leukocyte Antigen Antibodies After Transfusion in Adult Lung Transplantation.

Journal Article J Cardiothorac Vasc Anesth · September 2023 OBJECTIVES: The development of new human leukocyte antigens (HLAs) and donor-specific antibodies (DSAs) in patients are associated with worse outcomes following lung transplantation. The authors aimed to examine the relationship between blood product trans ... Full text Open Access Link to item Cite

Esophageal Adenocarcinoma: One Size Might Not Fit All.

Journal Article Ann Thorac Surg · September 2023 Full text Link to item Cite

Acid exposure time is sensitive for detecting gastroesophageal reflux disease and is associated with long-term survival after lung transplant.

Journal Article Dis Esophagus · July 27, 2023 Gastroesophageal reflux disease (GERD) is common in patients who have undergone lung transplantation and is associated with poorer outcomes, but guidelines are lacking to direct management strategies in this population. We assessed the diagnostic yield of ... Full text Link to item Cite

Intraoperative Red Blood Cell Transfusion and Primary Graft Dysfunction After Lung Transplantation.

Conference Transplantation · July 1, 2023 BACKGROUND: In this international, multicenter study of patients undergoing lung transplantation (LT), we explored the association between the amount of intraoperative packed red blood cell (PRBC) transfusion and occurrence of primary graft dysfunction (PG ... Full text Link to item Cite

Adeno-associated virus mediates gene transduction after static cold storage treatment in rodent lung transplantation.

Conference J Thorac Cardiovasc Surg · July 2023 OBJECTIVE: Adeno-associated virus is a clinically used gene therapy vector but has not been studied in lung transplantation. We sought to determine the efficacy of adeno-associated virus delivery during static cold storage via the airway versus the pulmona ... Full text Link to item Cite

Pulmonary Open, Robotic, and Thoracoscopic Lobectomy study: Outcomes and risk factors of conversion during minimally invasive lobectomy.

Conference J Thorac Cardiovasc Surg · July 2023 OBJECTIVE: Conversion to thoracotomy continues to be a concern during minimally invasive lobectomy. The aim of this propensity-matched cohort study is to analyze the outcomes and risk factors of intraoperative conversion during video-assisted thoracoscopic ... Full text Link to item Cite

Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study.

Journal Article J Heart Lung Transplant · June 2023 BACKGROUND: Chronic lung allograft dysfunction (CLAD) increases morbidity and mortality for lung transplant recipients. Club cell secretory protein (CCSP), produced by airway club cells, is reduced in the bronchoalveolar lavage fluid (BALF) of lung recipie ... Full text Link to item Cite

Pulmonary Open, Robotic, and Thoracoscopic Lobectomy (PORTaL) Study: Survival Analysis of 6646 Cases.

Journal Article Ann Surg · June 1, 2023 OBJECTIVE: The aim of this study was to analyze overall survival (OS) of robotic-assisted lobectomy (RL), video-assisted thoracoscopic lobectomy (VATS), and open lobectomy (OL) performed by experienced thoracic surgeons across multiple institutions. SUMMAR ... Full text Link to item Cite

(376) AAV9 PD-L1 Mediated Immunodulation of Donor Graft in Rat Lung Allotransplantation

Conference The Journal of Heart and Lung Transplantation · April 2023 Full text Cite

(593) Utilization of Lung Transplantation in Patients with Covid-19

Conference The Journal of Heart and Lung Transplantation · April 2023 Full text Cite

(921) Effect of Surgical Exposure on Short-Term Outcomes after Bilateral Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2023 Full text Cite

(260) Results of ECLS Support Comparing DCD and DBD Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2023 Full text Cite

A Randomized, Multicenter, Blinded Pilot Study Assessing the Effects of Gaseous Nitric Oxide in an Ex Vivo System of Human Lungs.

Conference Pulm Ther · March 2023 INTRODUCTION: Normothermic ex vivo lung perfusion (EVLP) is used to evaluate and condition donor lungs for transplantation. The objective of this study was to determine whether administration of exogenous nitric oxide during EVLP contributes to improvement ... Full text Link to item Cite

Same-teams versus different-teams for long distance lung procurement: A cost analysis.

Journal Article J Thorac Cardiovasc Surg · March 2023 OBJECTIVE: In an era of broader lung sharing, different-team transplantation (DT, procuring team from nonrecipient center) may streamline procurement logistics; however, safety and cost implications of DT remain unclear. To understand whether DT represents ... Full text Link to item Cite

Robotic Esophagectomy Trends and Early Surgical Outcomes: The US Experience.

Conference Ann Thorac Surg · March 2023 BACKGROUND: Recent esophagectomy trends were evaluated to describe the shift in surgical approach and outcomes using The Society of Thoracic Surgeons General Thoracic Surgery Database. METHODS: All patients who underwent an esophagectomy with gastric condu ... Full text Link to item Cite

Pulmonary Open, Robotic, and Thoracoscopic Lobectomy (PORTaL) Study: An Analysis of 5721 Cases.

Journal Article Ann Surg · March 1, 2023 OBJECTIVE: The aim of this study was to analyze outcomes of open lobectomy (OL), VATS, and robotic-assisted lobectomy (RL). SUMMARY BACKGROUND DATA: Robotic-assisted lobectomy has seen increasing adoption for treatment of early-stage lung cancer. Comparati ... Full text Link to item Cite

Addressing sex-based disparities in solid organ transplantation in the United States - a conference report.

Journal Article Am J Transplant · March 2023 Solid organ transplantation provides the best treatment for end-stage organ failure, but significant sex-based disparities in transplant access exist. On June 25, 2021, a virtual multidisciplinary conference was convened to address sex-based disparities in ... Full text Link to item Cite

Textbook Outcome: Definition and Analysis of a Novel Quality Measure in Lung Transplantation.

Journal Article Ann Surg · February 1, 2023 OBJECTIVE: To define textbook outcome (TO) for lung transplantation (LTx) using a contemporary cohort from a high-volume institution. SUMMARY BACKGROUND DATA: TO is a standardized, composite quality measure based on multiple postoperative endpoints represe ... Full text Link to item Cite

Utilization Trends and Volume-outcomes Relationship of Endoscopic Resection for Early Stage Esophageal Cancer.

Conference Ann Surg · January 1, 2023 OBJECTIVES: We describe utilization trends and center volume-outcomes relationship of ER of early stage esophageal cancer using a large hospitalbased registry. SUMMARY OF BACKGROUND DATA: ER is increasingly accepted as the preferred treatment for early sta ... Full text Link to item Cite

The American Association for Thoracic Surgery (AATS) 2022 Expert Consensus Document: The use of mechanical circulatory support in lung transplantation.

Journal Article J Thorac Cardiovasc Surg · January 2023 OBJECTIVE: The use of mechanical circulatory support (MCS) in lung transplantation has been steadily increasing over the prior decade, with evolving strategies for incorporating support in the preoperative, intraoperative, and postoperative settings. There ... Full text Link to item Cite

Comparison of Lung Utilization from Nrp-dcd vs Non-Nrp Dcd Using Evlp

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2023 Cite

Sterile inflammation in liver transplantation.

Journal Article Front Med (Lausanne) · 2023 Sterile inflammation is the immune response to damage-associated molecular patterns (DAMPs) released during cell death in the absence of foreign pathogens. In the setting of solid organ transplantation, ischemia-reperfusion injury results in mitochondria-m ... Full text Link to item Cite

Prioritization: Candidate Selection and Organ Allocation Systems

Chapter · January 1, 2023 Since the need for organs usually is higher than the supply of suitable organs, a process of determining which candidates should receive a particular organ is necessary. This means that a selection of who should be declined also is necessary; in other word ... Full text Cite

Techniques in Lung Transplantation

Chapter · January 1, 2023 Lung transplantation remains the gold standard therapy for patients suffering from end-stage lung disease, providing quality of life and prognostic benefits in otherwise severely debilitating, if not imminently fatal conditions. This chapter discusses some ... Full text Cite

AAV9-mediated gene delivery to liver grafts during static cold storage in a rat liver transplant model.

Journal Article Front Transplant · 2023 INTRODUCTION: Recombinant adeno-associated virus (rAAV) is a novel strategy used clinically for gene delivery, but has not been characterized in the context of organ transplantation. We sought to determine the efficacy of rAAV-mediated gene delivery during ... Full text Link to item Cite

Contemporary trends in PGD incidence, outcomes, and therapies.

Journal Article J Heart Lung Transplant · December 2022 BACKGROUND: We sought to describe trends in extracorporeal membrane oxygenation (ECMO) use, and define the impact on PGD incidence and early mortality in lung transplantation. METHODS: Patients were enrolled from August 2011 to June 2018 at 10 transplant c ... Full text Link to item Cite

Remote ex vivo lung perfusion at a centralized evaluation facility.

Journal Article J Heart Lung Transplant · December 2022 BACKGROUND: In the US, only 23% of lungs offered for transplantation are transplanted. Ex vivo lung perfusion (EVLP) allows for evaluation of additional donor lungs; its adoption has been limited by resources and expertise. Dedicated facilities with a cent ... Full text Link to item Cite

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

Journal Article Nat Aging · December 2022 Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretor ... Full text Link to item Cite

Effect of mode of intraoperative support on primary graft dysfunction after lung transplant.

Journal Article J Thorac Cardiovasc Surg · November 2022 OBJECTIVE: To clarify the relationship between the use of extracorporeal life support during lung transplantation and severe primary graft dysfunction (PGD), we developed and analyzed a novel multicenter international registry. METHODS: The Extracorporeal ... Full text Link to item Cite

Risk of Each of the Five Lung Lobectomies: A Society of Thoracic Surgeons Database Analysis.

Journal Article Ann Thorac Surg · November 2022 BACKGROUND: The perioperative risk of pulmonary lobectomy as a solitary procedure has been extensively studied, yet the differences in outcomes between lobes, which have unique anatomy and a different amount of lung parenchyma, are entirely unknown. The pu ... Full text Link to item Cite

Textbook outcome in lung transplantation: Planned venoarterial extracorporeal membrane oxygenation versus off-pump support for patients without pulmonary hypertension.

Journal Article J Heart Lung Transplant · November 2022 BACKGROUND: Planned venoarterial extracorporeal membrane oxygenation (VA ECMO) is increasingly used during bilateral orthotopic lung transplantation (BOLT) and may be superior to off-pump support for patients without pulmonary hypertension. In this single- ... Full text Link to item Cite

Subnormothermic ex vivo lung perfusion attenuates graft inflammation in a rat transplant model.

Journal Article J Thorac Cardiovasc Surg · August 2022 OBJECTIVE: Ex vivo lung perfusion has emerged as a novel technique to safely preserve lungs before transplantation. Recent studies have demonstrated an accumulation of inflammatory molecules in the perfusate during ex vivo lung perfusion. These proinflamma ... Full text Link to item Cite

Conversion to Thoracotomy During Thoracoscopic vs Robotic Lobectomy: Predictors and Outcomes.

Journal Article Ann Thorac Surg · August 2022 BACKGROUND: Conversion to thoracotomy during minimally invasive lobectomy for lung cancer is occasionally necessary. Differences between video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracoscopic surgery (RATS) lobectomy conversion have ... Full text Link to item Cite

Commentary: Zenker's diverticulum: One size does not fit all.

Journal Article J Thorac Cardiovasc Surg · June 2022 Full text Link to item Cite

Lung Transplantation After Ex Vivo Lung Perfusion Early Outcomes From a US National Registry.

Journal Article Ann Surg · May 1, 2022 OBJECTIVE: The objective of this study was to examine early lung transplant outcomes following EVLP using a large national transplant registry. SUMMARY OF BACKGROUND DATA: Lung transplantation in the United States continues to be constrained by a limited s ... Full text Link to item Cite

Lung Retransplantation.

Journal Article Thorac Surg Clin · May 2022 Lung retransplantation remains the standard treatment of irreversible lung allograft failure. The most common indications for lung retransplantation are acute graft failure, chronic lung allograft dysfunction, and postoperative airway complications. Carefu ... Full text Link to item Cite

Textbook surgical outcome in lung transplantation: Analysis of a US national registry.

Journal Article Clin Transplant · April 2022 INTRO: Textbook surgical outcome (TO) is a novel composite quality measure in lung transplantation (LTx). Compared to 1-year survival metrics, TO may better differentiate center performance, and motivate improvements in care. To understand the feasibility ... Full text Link to item Cite

Factors associated with short- versus long-term survival after lung transplant.

Journal Article J Thorac Cardiovasc Surg · March 2022 OBJECTIVE: A small but growing proportion of lung transplant recipients survive longer than a decade post-transplant. The aim of this study was to identify factors associated with survival beyond a decade after lung transplant. METHODS: We queried the Unit ... Full text Link to item Cite

Perioperative Outcomes of Thymectomy in Myasthenia Gravis: A Thoracic Surgery Database Analysis.

Journal Article Ann Thorac Surg · March 2022 BACKGROUND: There is clinical equipoise regarding the perioperative and long-term outcomes of autoimmune myasthenia gravis (MG) patients undergoing open vs minimally invasive thymectomy, particularly for nonthymomatous MG. This analysis utilizes multicente ... Full text Link to item Cite

Lung transplantation after ex vivo lung perfusion versus static cold storage: An institutional cost analysis.

Journal Article Am J Transplant · February 2022 Ex vivo lung perfusion (EVLP) is a novel lung preservation strategy that facilitates the use of marginal allografts; however, it is more expensive than static cold storage (SCS). To understand how preservation method might affect postoperative costs, we co ... Full text Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Comparison of Forceps, Cryoprobe, and Thoracoscopic Lung Biopsy for the Diagnosis of Interstitial Lung Disease - The CHILL Study.

Journal Article Respiration · 2022 RATIONALE: Transbronchial lung cryobiopsy (TBLC) has emerged as a less invasive method to obtain a tissue diagnosis in patients with interstitial lung disease (ILD). The diagnostic yield of TBLC compared to surgical lung biopsy (SLB) remains uncertain. OBJ ... Full text Link to item Cite

Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial.

Journal Article JAMA Surg · January 1, 2022 IMPORTANCE: Inhaled nitric oxide (iNO) is commonly administered for selectively inhaled pulmonary vasodilation and prevention of oxidative injury after lung transplant (LT). Inhaled epoprostenol (iEPO) has been introduced worldwide as a cost-saving alterna ... Full text Open Access Link to item Cite

Two Compartment Evaluation of Liver Grafts During Acellular Room Temperature Machine Perfusion (acRTMP) in a Rat Liver Transplant Model.

Journal Article Front Med (Lausanne) · 2022 BACKGROUND: Subnormothermic machine perfusion (SNMP) of liver grafts is currently less clinically developed than normothermic and hypothermic approaches, but may have logistical advantages. At intermediate temperatures, the oxygen demand of the graft is lo ... Full text Link to item Cite

Is Acute Rejection Truly Acute or an Exacerbation of an Underlying Disease?

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Gene Therapy: Will the Promise of Optimizing Lung Allografts Become Reality?

Journal Article Front Immunol · 2022 Lung transplantation is the definitive therapy for patients living with end-stage lung disease. Despite significant progress made in the field, graft survival remains the lowest of all solid organ transplants. Additionally, the lung has among the lowest of ... Full text Link to item Cite

Textbook Outcome in Lung Transplantation: Planned VA ECMO versus Off-Pump.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2022 Cite

Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery.

Journal Article Front Immunol · 2022 Organ shortages and an expanding waitlist have led to increased utilization of marginal organs. All donor organs are subject to varying degrees of IRI during the transplant process. Extended criteria organs, including those from older donors and organs don ... Full text Link to item Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal Article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Lung transplantation using allografts with more than 8 hours of ischemic time: A single-institution experience.

Conference J Heart Lung Transplant · November 2021 BACKGROUND: Six hours was historically regarded as the limit of acceptable ischemic time for lung allografts. However, broader sharing of donor lungs often necessitates use of allografts with ischemic time >6 hours. We characterized the association between ... Full text Link to item Cite

Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation.

Journal Article J Heart Lung Transplant · November 2021 Tens of thousands of patients with advanced lung diseases may be eligible to be considered as potential candidates for lung transplant around the world each year. The timing of referral, evaluation, determination of candidacy, and listing of candidates con ... Full text Link to item Cite

ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part III: Pharmacology, medical and surgical management of post-transplant extrapulmonary conditions statements.

Journal Article J Heart Lung Transplant · November 2021 Patients with connective tissues disease (CTD) are often on immunomodulatory agents before lung transplantation (LTx). Till now, there's no consensus on the safety of using these agents perioperative and post-transplant. The International Society for Heart ... Full text Link to item Cite

Lung retransplantation in the modern era.

Journal Article J Thorac Dis · November 2021 Chronic lung allograft dysfunction remains the leading cause of long-term morbidity and mortality for lung transplant recipients. Lung retransplantation currently represents the only therapeutic option for patients for refractory allograft dysfunction. How ... Full text Link to item Cite

Commentary: New lungs may be right around the corner.

Journal Article J Thorac Cardiovasc Surg · October 2021 Full text Link to item Cite

The Role of Surgical Lung Biopsy in the Diagnosis of Fibrotic Interstitial Lung Disease: Perspective from the Pulmonary Fibrosis Foundation.

Journal Article Ann Am Thorac Soc · October 2021 Diagnosis of interstitial lung disease (ILD) requires a multidisciplinary discussion approach that includes clinicians, radiologists, and pathologists. Surgical lung biopsy (SLB) is currently the recommended standard in obtaining pathologic specimens for p ... Full text Link to item Cite

Blood product transfusion and lung transplant outcomes: A systematic review.

Journal Article Clin Transplant · October 2021 The perioperative transfusion of blood products has long been linked to development of acute lung injury and associated with mortality across both medical and surgical patient populations.1,2 The need for blood product transfusion during and after lung tra ... Full text Link to item Cite

Point-of-Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model.

Journal Article Hepatol Commun · September 2021 Normothermic machine perfusion (NMP) provides clinicians an opportunity to assess marginal livers before transplantation. However, objective criteria and point-of-care (POC) biomarkers to predict risk and guide decision making are lacking. In this investig ... Full text Link to item Cite

Aggressive pursuit and utilization of non-ideal donor lungs does not compromise post-lung transplant survival.

Journal Article Clin Transplant · September 2021 BACKGROUND: Organ procurement organizations (OPOs) vary in willingness to pursue and utilize non-ideal donor lungs; implications of these practices for lung transplant (LTx) recipients remain unclear. We examined associations between OPO-level behavior tow ... Full text Link to item Cite

Reexamining Risk Aversion: Willingness to Pursue and Utilize Nonideal Donor Livers Among US Donation Service Areas.

Journal Article Transplant Direct · September 2021 BACKGROUND: Livers from "nonideal" but acceptable donors are underutilized; however, organ procurement organization (OPO) metrics do not assess how OPO-specific practices contribute to these trends. In this analysis, we evaluated nonideal liver donor avoid ... Full text Open Access Link to item Cite

Expanding donor availability in lung transplantation: A case report of 5000 miles traveled.

Journal Article Am J Transplant · June 2021 We present the case of a 41-year-old female who underwent bilateral lung transplantation after the donor lungs were placed on a normothermic ex vivo lung perfusion and ventilation device and flown nearly 5000 miles from Honolulu, Hawaii to Durham, North Ca ... Full text Link to item Cite

Discussion.

Journal Article J Thorac Cardiovasc Surg · May 2021 Full text Link to item Cite

Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference.

Journal Article Ann Thorac Surg · April 2021 BACKGROUND: Heart transplantation is limited by the supply of donor organs. Previous studies have associated female donor to male recipient with decreased posttransplant survival. We wanted to evaluate whether this risk can be mitigated using higher donor ... Full text Link to item Cite

Hyperbaric oxygen therapy to prevent central airway stenosis after lung transplantation.

Journal Article J Heart Lung Transplant · April 2021 BACKGROUND: Central airway stenosis (CAS) is a severe airway complication after lung transplantation associated with bronchial ischemia and necrosis. We sought to determine whether hyperbaric oxygen therapy (HBOT), an established treatment for tissue ische ... Full text Link to item Cite

Safety and efficacy of an implantable device for management of gastroesophageal reflux in lung transplant recipients.

Journal Article J Thorac Dis · April 2021 BACKGROUND: Magnetic sphincter augmentation (MSA) is a promising minimally invasive surgical technique for management of gastroesophageal reflux disease (GERD); however, device implantation after transplantation has not been studied and may be concerning i ... Full text Link to item Cite

A three-tier system for evaluation of organ procurement organizations' willingness to pursue and utilize nonideal donor lungs.

Journal Article Am J Transplant · March 2021 Lungs from "nonideal," but acceptable donors are underutilized; however, organ procurement organization (OPO) metrics do not reflect the extent to which OPO-specific practices contribute to these trends. We developed a comprehensive system to evaluate noni ... Full text Link to item Cite

Dual Procurement of Lung and Heart Allografts Does Not Negatively Affect Lung Transplant Outcomes.

Journal Article J Surg Res · March 2021 BACKGROUND: The data that exists regarding multiorgan procurement outcomes is conflicted. Given the increasing demand for pulmonary allografts, it is critical to assess the impact of dual procurement on lung transplant recipient outcomes. METHODS: The Unit ... Full text Link to item Cite

Corrigendum.

Journal Article J Heart Lung Transplant · March 2021 Full text Link to item Cite

Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.

Journal Article Sci Rep · February 4, 2021 Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) derived lipids play key roles in initiating and resolving inflammation. Neuro-inflammation is thought to play a causal role in perioperative neurocognitive disorders, yet th ... Full text Open Access Link to item Cite

Predictors of nonuse of donation after circulatory death lung allografts.

Journal Article J Thorac Cardiovasc Surg · February 2021 OBJECTIVE: Despite growing evidence of comparable outcomes in recipients of donation after circulatory death and donation after brain death donor lungs, donation after circulatory death allografts continue to be underused nationally. We examined predictors ... Full text Link to item Cite

Center volume and primary graft dysfunction in patients undergoing lung transplantation in the United States - a cohort study.

Journal Article Transpl Int · January 2021 Lung transplantation primary graft dysfunction (PGD) is common and portends poor outcomes. We examined the association of lung transplant center volume with PGD and the risk of mortality. The United Network for Organ Sharing transplant registry was queried ... Full text Link to item Cite

Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2021 BACKGROUND: Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized to result from neuroinflammation; ... Full text Open Access Link to item Cite

Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality.

Journal Article Curr Transplant Rep · 2021 PURPOSE OF REVIEW: We examined data from the last 5 years describing extracorporeal life support (ECLS) as a bridge to lung transplantation. We assessed predictors of survival to transplantation and post-transplant mortality. RECENT FINDINGS: The number of ... Full text Link to item Cite

Inhaled Selective Pulmonary Vasodilators for Adult Lung Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

Transfusion Requirements during Lung Transplantation: Elective VA ECMO vs. Off-Pump

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

Predicting PGD after Lung Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

Rising PGD Incidence Parallels Increased Recipient Disease Severity

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

Predictors of Older Donor Lung Use: Are We Too Good at Saying No?

Journal Article Ann Thorac Surg · November 2020 BACKGROUND: Patterns of use of older donor lungs within this previously underused donor population are poorly characterized. This study examined factors associated with the use of older donor lung allografts and factors associated with survival in recipien ... Full text Link to item Cite

The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients.

Journal Article J Cardiothorac Vasc Anesth · November 2020 OBJECTIVES: Lung transplantation is associated with a significant risk of needed transfusion. Although algorithm-based transfusion strategies that promote a high fresh frozen plasma:red blood cells (FFP:RBC) ratio have reduced overall blood product require ... Full text Link to item Cite

Lung transplantation during the COVID-19 pandemic: Safely navigating the new "normal".

Journal Article Am J Transplant · November 2020 In the United States, an overall national decline in organ transplants has accompanied the substantial burden of COVID-19. Amidst significant regional variations in COVID-19, lung transplantation (LTx) remains a critical life-saving operation. Our LTx prac ... Full text Link to item Cite

Endobronchial coils for emphysema: Dual mechanism of action on lobar residual volume reduction.

Journal Article Respirology · November 2020 BACKGROUND AND OBJECTIVE: The RENEW trial demonstrated that bronchoscopic lung volume reduction using endobronchial coils improves quality of life, pulmonary function and exercise performance. In this post hoc analysis of RENEW, we examine the mechanism of ... Full text Link to item Cite

Resection of the irradiated esophagus: the impact of lymph node yield on survival.

Journal Article Dis Esophagus · October 12, 2020 There is debate surrounding the appropriate threshold for lymph node harvest during esophagectomy in patients with esophageal cancer, specifically for those receiving preoperative radiation. The purpose of this study was to determine the impact of lymph no ... Full text Link to item Cite

Extended post-ex vivo lung perfusion cold preservation predicts primary graft dysfunction and mortality: Results from a multicentric study.

Journal Article J Heart Lung Transplant · September 2020 BACKGROUND: Ex vivo lung perfusion (EVLP) allows for a reassessment of lung grafts initially deemed unsuitable for transplantation, increasing the available donor pool; however, this requires a pre- and post-EVLP period of cold ischemic time (CIT). Paucity ... Full text Link to item Cite

Increased Calculated Panel Reactive Antigen Is Associated With Increased Waitlist Time and Mortality in Lung Transplantation.

Journal Article Ann Thorac Surg · August 2020 BACKGROUND: Sensitized candidates with unacceptable antigens are a group that demands special attention in organ transplantation. Calculated panel reactive antigen (cPRA) is not used to modify allocation priorities in lung transplantation. The impact of cP ... Full text Link to item Cite

Sirtuin-1 expression and activity is diminished in aged liver grafts.

Journal Article Sci Rep · July 17, 2020 The cellular mechanisms underlying impaired function of aged liver grafts have not been fully elucidated, but mitochondrial dysfunction appears to be contributory. Sirtuin1 has been identified as a key mediator of mitochondrial recovery following ischemia- ... Full text Link to item Cite

Disparities in guideline-concordant treatment for node-positive, non-small cell lung cancer following surgery.

Conference J Thorac Cardiovasc Surg · July 2020 OBJECTIVES: To examine guideline concordance across a national sample and determine the relationship between socioeconomic factors, use of recommended postoperative adjuvant therapy, and outcomes for patients with resected pN1 or pN2 non-small cell lung ca ... Full text Link to item Cite

The effect of age on survival after endoscopic resection versus surgery for T1a esophageal cancer.

Conference J Thorac Cardiovasc Surg · July 2020 BACKGROUND: Endoscopic resection has emerged as a treatment option for T1a esophageal cancer, but the impact of age on patient selection for surgery versus endoscopic resection has not been well studied. We hypothesized that endoscopic resection would be a ... Full text Link to item Cite

Anticoagulation Strategies in the Perioperative Period for Lung Transplant.

Journal Article Ann Thorac Surg · July 2020 Patients who are undergoing lung transplantation may require systemic anticoagulation in the perioperative period for various indications at the time of the procedure. Four-factor prothrombin complex concentrate has been approved in the United States to re ... Full text Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Transplant Center Variability in Organ Offer Acceptance and Mortality Among US Patients on the Heart Transplant Waitlist.

Journal Article JAMA Cardiol · June 1, 2020 IMPORTANCE: Under the current Centers for Medicare & Medicaid Services guidelines, there is incentivization to optimize posttransplant outcomes regardless of mortality among patients on the waitlist and transplant rates; few data exist with regard to trans ... Full text Link to item Cite

Constrictive Pericarditis After Lung Transplantation.

Journal Article Transplantation · May 2020 BACKGROUND: Constrictive pericarditis is a rare, but increasingly recognized long-term postoperative complication of lung transplantation. Heightened clinical suspicion, improved diagnostic imaging, and effective surgical treatment of the disease have led ... Full text Link to item Cite

Utilization of hepatitis C virus-infected organ donors in cardiothoracic transplantation: An ISHLT expert consensus statement.

Journal Article J Heart Lung Transplant · May 2020 The advent of therapies for successful treatment of hepatitis C virus has allowed the heart and lung transplant community to re-explore the use of hepatitis C virus-positive donors for organ transplantation, with a benefit for many terminally ill patients. ... Full text Link to item Cite

Variability in donor organ offer acceptance and lung transplantation survival.

Journal Article J Heart Lung Transplant · April 2020 BACKGROUND: Lung transplantation offers a survival benefit for patients with end-stage lung disease. When suitable donors are identified, centers must accept or decline the offer for a matched candidate on their waitlist. The degree to which variability in ... Full text Link to item Cite

Effect of Time of Intraoperative Circulatory Support on Incidence of High-Grade Primary Graft Dysfunction (PGD): Multicenter Analysis on Use of Extracorporeal Life Support (ECLS) during Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Prior single center experiences suggest that use of ECLS during lung transplantation (LT) increases the risk of PGD. Here we analyze the effects of intraoperative ECLS time on PGD after LT in a multicenter ECLS registry. METHODS: The ECLS in LT re ... Full text Cite

Effect of Cold Ischemic Time on the Incidence of High-Grade Primary Graft Dysfunction (PGD): A Multicenter Analysis

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Prior studies have explored the effects of cold ischemic time on survival but its effect on PGD is unclear. The current study analyzed an international multicenter ECLS in lung transplantation registry to clarify the effects of cold ischemic time ... Full text Cite

Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Transfusion during lung transplantation (LT) is linked to primary graft dysfunction (PGD) and worsened outcomes. Goal-directed protocols have improved outcomes in cardiac surgical populations and decreased transfusions in LT on cardiopulmonary byp ... Full text Cite

Perioperative Characteristics Associated with Transfusion-Free Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Blood transfusion during lung transplantation (LT) surgery is common. There is little evidence to identify potential candidates for transfusion-free LT surgery. We describe patient and procedural characteristics of LT patients in the era of ECMO a ... Full text Cite

Five Year Follow-Up of Staged Bilateral Lung Transplantation for High-Risk Patients with Interstitial Lung Disease: A Matched Case-Control Study

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: The choice of single (SOLT) or bilateral orthotopic lung transplant (BOLT) for interstitial lung disease (ILD) remains controversial. Our center adopted a staged BOLT approach for higher surgical risk ILD patients, in which they undergo a single l ... Full text Cite

Implications of ECMO Bridging and Salvage Strategies on Mortality and PGD

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: ECMO is increasingly used for bridging and salvage therapies in lung transplantation, with favorable short-term results. Mid- to long-term outcomes of ECMO use for bridging and salvage are incompletely understood, as is effect on PGD risk; therefo ... Full text Cite

The NOVEL Study. A Multi-Center Clinical Trial Studying the Safety of Ex Vivo Lung Perfusion

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: lung transplantation continues to be a life saving therapy for patients with end stage lung disease. In a donor restrictive environment and with only 22% of donor lungs currently being transplanted ex vivo lung perfusion can increase donor use and ... Full text Cite

Extended Post EVLP Cold Preservation Increases Risk of Primary Graft Dysfunction and Mortality

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: EVLP allows for reassessment of lung grafts initially deemed unsuitable for transplantation, increasing the available donor pool. Standard cold preservation is followed by normothermic EVLP, then lungs undergo a second cold preservation prior to i ... Full text Cite

Is There a Role for Surgery in Patients with Neuroendocrine Tumors of the Esophagus? A Contemporary View from the NCDB.

Conference Ann Surg Oncol · March 2020 BACKGROUND: Esophageal neuroendocrine tumors (eNETs) are exceedingly rare, aggressive and have a poor prognosis. Treatment guidelines are ill-defined and mainly based on evidence from case reports and analogous experiences drawn from similar disease sites. ... Full text Link to item Cite

Patient-Reported Chronic Pain Outcomes After Lung Transplantation.

Journal Article Semin Cardiothorac Vasc Anesth · March 2020 Chronic pain after lung transplantation is a significant concern, in particular given the heterogeneity of the patient population and the challenges of achieving adequate pain control amid concerns related to complex immunosuppressant regimens and the poss ... Full text Link to item Cite

Donor Leukocyte Trafficking and Damage-associated Molecular Pattern Expression During Ex Vivo Lung Perfusion.

Journal Article Transplant Direct · March 2020 BACKGROUND: While ex vivo lung perfusion (EVLP) has become established in lung transplantation, the cellular processes occurring during this period are not yet fully understood. Prior studies demonstrated that donor leukocytes (DLs) migrate from the graft ... Full text Open Access Link to item Cite

Failure to Rescue Contributes to Center-Level Differences in Mortality After Lung Transplantation.

Journal Article Ann Thorac Surg · January 2020 BACKGROUND: The clinical response to postoperative complications after lung transplantation (LTx) may contribute to mortality differences among transplantation centers. The ability to avoid mortality after a complication-failure to rescue (FTR)-may be an e ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

The Robotic Method of Repairing Dysphagia.

Journal Article Innovations (Phila) · 2020 Full text Link to item Cite

Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.

Conference Dis Esophagus · December 13, 2019 Gastroesophageal reflux and esophageal dysmotility are common in patients with advanced lung disease and are associated with allograft dysfunction after lung transplantation. The effect of transplantation on reflux and esophageal motility is unclear. The a ... Full text Link to item Cite

Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.

Journal Article Anesth Analg · November 2019 Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before and after major noncardiac surgery ... Full text Open Access Link to item Cite

Impact of Donor Brain Death Duration on Outcomes After Lung Transplantation.

Journal Article Ann Thorac Surg · November 2019 BACKGROUND: Donor brain death duration (BDD) may impact posttransplant graft function and survival in lung transplant. METHODS: We queried the 2007 to 2018 United Network for Organ Sharing Registry for adult recipients undergoing first-time isolated lung t ... Full text Link to item Cite

Donor and recipient age matching in heart transplantation: analysis of the UNOS Registry.

Journal Article Transpl Int · November 2019 The association of donor and recipient age with survival following adult heart transplantation has not been well characterized. The purpose of this study was to examine the impact of the relationship between donor and recipient age on post-transplant survi ... Full text Link to item Cite

Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial.

Journal Article Lancet Respir Med · November 2019 BACKGROUND: Donor lung use for transplantation is the lowest among solid organ tranplants because of several complex and multifactorial reasons; one area that could have a substantial role is the limited capabilities of cold ischaemic storage. The aim of t ... Full text Link to item Cite

Technical Options and Approaches to Lengthen the Shortened Esophagus.

Journal Article Thorac Surg Clin · November 2019 Failure to recognize a short esophagus during paraesophageal hernia repair can lead to poor functional outcomes and increased recurrence rates. Diagnosis is usually done intraoperatively when less than 2 to 3 cm of esophagus lie in the intraabdominal posit ... Full text Link to item Cite

Elevated Donor Hemoglobin A1C Impairs Kidney Graft Survival From Deceased Donors With Diabetes Mellitus: A National Analysis.

Journal Article Exp Clin Transplant · October 2019 OBJECTIVES: Kidney transplant is the optimal therapy for patients with end-stage renal disease. The presence of donor diabetes mellitus is a recognized risk factor for impaired kidney graft survival and is incorporated into the Kidney Donor Profile Index. ... Full text Link to item Cite

Left Transthoracic Approach for Magnetic Sphincter Augmentation Device LINX Implantation.

Journal Article Ann Thorac Surg · October 2019 Magnetic sphincter augmentation with the LINX Reflux Management System (Torax Medical, St. Paul, MN) is a recently introduced surgical option with comparable therapeutic efficacy for medically refractory gastroesophageal reflux disease. An appropriately si ... Full text Link to item Cite

Heart Transplantation Survival and the Use of Traumatically Brain-Injured Donors: UNOS Registry Propensity-Matched Analysis.

Journal Article J Am Heart Assoc · September 3, 2019 Background The transplantation of hearts from traumatically brain-injured (TBI) donors has been associated with inferior long-term survival in single-center analyses. However, in a more recent analysis, death caused by cerebrovascular accident was associat ... Full text Link to item Cite

Single lung transplantation in patients with severe secondary pulmonary hypertension.

Journal Article J Heart Lung Transplant · September 2019 BACKGROUND: The optimal transplant strategy for patients with end-stage lung disease complicated by secondary pulmonary hypertension (PH) is controversial. The aim of this study is to define the role of single lung transplantation in this population. METHO ... Full text Link to item Cite

A Propensity-matched Survival Analysis: Do Simultaneous Liver-lung Transplant Recipients Need a Liver?

Conference Transplantation · August 2019 BACKGROUND: There is debate whether simultaneous lung-liver transplant (LLT) long-term outcomes warrant allocation of 2 organs to a single recipient. We hypothesized that LLT recipients would have improved posttransplant survival compared with matched sing ... Full text Link to item Cite

Improvement in Liver Transplant Outcomes From Older Donors: A US National Analysis.

Journal Article Ann Surg · August 2019 OBJECTIVE: To investigate trends in long-term graft and patient outcomes following liver transplantation using grafts from donors ≥60 years old. SUMMARY BACKGROUND DATA: The scarcity of donor livers has led to increased utilization of organs from donors ≥6 ... Full text Link to item Cite

Challenging 30-day mortality as a site-specific quality metric in non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · August 2019 OBJECTIVE: The objective of this project was to assess the best measure for postoperative outcomes by comparing 30-day and 90-day mortality rates after surgery for non-small cell lung cancer using the National Cancer Database. Secondarily, hospital perform ... Full text Link to item Cite

Perioperative Anesthetic and Transfusion Management of Veno-Venous Extracorporeal Membrane Oxygenation Patients Undergoing Noncardiac Surgery: A Case Series of 21 Procedures.

Journal Article J Cardiothorac Vasc Anesth · July 2019 OBJECTIVES: To analyze the perioperative management of veno-venous extracorporeal membrane oxygenation (VV ECMO) in patients undergoing major noncardiac surgical procedures, which is poorly described in the literature. In doing so, perioperative challenges ... Full text Link to item Cite

Machine Perfusion of Liver Grafts With Implantable Oxygen Biosensors: Proof of Concept Study in a Rodent Model.

Journal Article Transplant Direct · July 2019 BACKGROUND: Normothermic machine perfusion (NMP) is emerging as a novel preservation strategy in liver transplantation, but the optimal methods for assessing liver grafts during this period have not been determined. The aim of this study was to investigate ... Full text Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

Predictors of Response to Endobronchial Coil Therapy in Patients With Advanced Emphysema.

Journal Article Chest · May 2019 BACKGROUND: The Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) trial reported improvements in quality of life, pulmonary function, and exercise performance following endobronchial coil treatment. OBJECTIVES: The purpose of this pos ... Full text Link to item Cite

Right-Sided Versus Left-Sided Pneumonectomy After Induction Therapy for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · April 2019 BACKGROUND: A right-sided pneumonectomy after induction therapy for non-small cell lung cancer (NSCLC) has been shown to be associated with significant perioperative risk. We examined the effect of laterality on long-term survival after induction therapy a ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology.

Journal Article Liver Transpl · April 2019 Machine preservation (MP) has emerged as a promising technology in liver transplantation, but the cellular processes occurring during MP have not been characterized. Recent studies have noted the presence of inflammatory molecules generated during MP. We h ... Full text Link to item Cite

Center Variability in Organ Offer Acceptance and Waitlist Mortality in Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Time from Lung Transplant Donor Brain Death to Cross Clamp: An Analysis of the UNOS Registry

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Mitigating the Impact of Gender Mismatch in Heart Transplantation Using BMI and BSA Ratios

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Heart Transplantation Survival and the Use of Traumatically Brain-Injured Donors

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Early experience with the use of hepatitis C antibody-positive, nucleic acid testing-negative donors in lung transplantation.

Journal Article Clin Transplant · March 2019 Historically, potential lung donors who have detectable antibodies to hepatitis C virus have been declined by most centers due to concern for possible disease transmission. We sought to evaluate hepatitis C viral transmission rates from donors who were kno ... Full text Link to item Cite

Implications of declining donor offers with increased risk of disease transmission on waiting list survival in lung transplantation.

Journal Article J Heart Lung Transplant · March 2019 BACKGROUND: Donors with characteristics that may increase the likelihood of disease transmission with transplantation are noted as increased risk via Public Health Service criteria. This study aimed to establish the implications of declining an increased-r ... Full text Link to item Cite

A National Analysis of Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Stage I Non-small-cell Lung Cancer.

Journal Article Ann Surg · January 2019 OBJECTIVE: The objective of this study was to compare the long-term survival of open versus thoracoscopic (VATS) lobectomy for early stage non-small-cell lung cancer (NSCLC). BACKGROUND: Data from national studies on long-term survival for VATS versus open ... Full text Link to item Cite

Implications of blood group on lung transplantation rates: A propensity-matched registry analysis.

Journal Article J Heart Lung Transplant · January 2019 BACKGROUND: Blood type O lung allografts may be allocated to blood type identical (type O) or compatible (non-O) candidates. We tested the hypothesis that the current organ allocation schema in the United States-based on the Lung Allocation Score-prejudice ... Full text Link to item Cite

Simultaneous Versus Sequential Heart-liver Transplantation: Ideal Strategies for Organ Allocation.

Journal Article Transplant Direct · January 2019 BACKGROUND: Simultaneous heart-liver (SHL) transplantation is an efficacious therapeutic modality for patients with combined heart and liver failure. However, the extent to which heart transplantation followed by sequential liver transplantation (LAH) can ... Full text Link to item Cite

DAMP Release and Inflammasome Activation during Machine Preservation of the Liver

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2019 Link to item Cite

Respiratory Complications of Gastroesophageal Reflux Disease

Chapter · January 1, 2019 Gastroesophageal reflux refers to the reflux of stomach contents into the esophagus. Gastroesophageal reflux disease (GERD) describes the presence of excessive reflux of acid or nonacid stomach contents, with unwanted resultant manifestations. Although tra ... Full text Cite

National Heart, Lung, and Blood Institute and American Association for Thoracic Surgery Workshop Report: Identifying collaborative clinical research priorities in lung transplantation.

Journal Article J Thorac Cardiovasc Surg · December 2018 This report summarizes the discussion and recommendations from the June 2017 NHLBI-AATS Workshop on Identifying Collaborative Clinical Research Priorities in Lung Transplantation. ... Full text Link to item Cite

Higher Use of Surgery Confers Superior Survival in Stage I Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · November 2018 BACKGROUND: Lobar resection is the gold standard therapy for medically fit patients with stage I non-small cell lung cancer (NSCLC). However, considerable variability exists in the use of surgical therapy. This study tested the hypothesis that center-based ... Full text Link to item Cite

Improved survival in simultaneous lung-liver recipients and candidates in the modern era of lung allocation.

Journal Article J Surg Res · November 2018 BACKGROUND: Liver-lung transplantation (LLT) is a rare procedure performed for patients with end-stage liver and lung disease. The lung allocation score (LAS), introduced in 2005, guides lung allocation including those receiving LLT. However, the impact of ... Full text Link to item Cite

All evidence points to the need for collaborative care.

Journal Article J Thorac Cardiovasc Surg · August 2018 Full text Link to item Cite

Is Functional Independence Associated With Improved Long-Term Survival After Lung Transplantation?

Journal Article Ann Thorac Surg · July 2018 BACKGROUND: Existing research demonstrates superior short-term outcomes (length of stay, 1-year survival) after lung transplantation in patients with preoperative functional independence. The aim of this study was to determine whether advantages remain sig ... Full text Link to item Cite

CXCR4 Inhibition Improves Donor Leukocyte Depletion during Ex Vivo Lung Perfusion.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2018 Link to item Cite

Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.

Journal Article Dis Esophagus · May 1, 2018 Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients with advanced lung disease and are associated with graft dysfunction following lung transplantation. As a result, many transplant centers perform esophageal function testi ... Full text Open Access Link to item Cite

Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes.

Journal Article Transplant Direct · May 2018 BACKGROUND: Combined lung-liver transplantation (LLT) applies 2 technically challenging transplants in 1 patient with severe 2-organ failure. METHODS: Institutional medical records and United Network for Organ Sharing database were queried for patients at ... Full text Open Access Link to item Cite

Single Lung Transplantation in Patients with Severe Secondary Pulmonary Hypertension

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Neurological Sequelae and Clinical Outcomes After Lung Transplantation.

Journal Article Transplant Direct · April 2018 BACKGROUND: Neurological complications are common after lung transplantation. However, no large cohort studies have examined the incidence, predictors, and clinical significance of neurological events sustained by lung transplant recipients. METHODS: We co ... Full text Open Access Link to item Cite

Impact of Ischemic Time on Primary Graft Dysfunction: A National Analysis

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

CXCR4 Inhibition Improves Donor Leukocyte Depletion During Ex Vivo Lung Perfusion

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Survival after radiation for stage I and II non-small cell lung cancer with positive margins.

Journal Article J Surg Res · March 2018 BACKGROUND: There is limited data guiding treatment for positive margins following lobectomy for early-stage non-small cell lung cancer (NSCLC). Using data from the National Cancer Data Base, we sought to determine whether radiation therapy following lobec ... Full text Link to item Cite

Robot-assisted repair of diaphragmatic hernias following ventricular assist device implantation.

Journal Article J Surg Case Rep · February 2018 Use of ventricular assist devices (VADs) is increasingly common, as is the need for surgeons to be familiar with the management of common complications in this population. Nonetheless, repair of diaphragmatic hernias which commonly develop following VAD im ... Full text Link to item Cite

Quantitative Evidence for Revising the Definition of Primary Graft Dysfunction after Lung Transplant.

Journal Article Am J Respir Crit Care Med · January 15, 2018 RATIONALE: Primary graft dysfunction (PGD) is a form of acute lung injury that occurs after lung transplantation. The definition of PGD was standardized in 2005. Since that time, clinical practice has evolved, and this definition is increasingly used as a ... Full text Link to item Cite

Survival after lung transplantation in recipients with alpha-1-antitrypsin deficiency compared to other forms of chronic obstructive pulmonary disease: a national cohort study.

Journal Article Transpl Int · January 2018 Alpha-1-antitrypsin deficiency (AATD) is grouped with chronic obstructive pulmonary disease (COPD); however, this may not be appropriate. This study assessed whether AATD confers a different prognosis than COPD following lung transplantation. We employed t ... Full text Link to item Cite

Getting to transplantation.

Journal Article Am J Transplant · January 2018 Full text Link to item Cite

Long-term outcomes of surgical resection for stage IV non-small-cell lung cancer: A national analysis.

Journal Article Lung Cancer · January 2018 OBJECTIVE: Treatment guidelines recommend surgical resection in select cases of stage IV non-small-cell lung cancer (NSCLC) but are based on limited evidence. This study evaluated outcomes associated with surgery in stage IV disease. METHODS: Factors assoc ... Full text Link to item Cite

Impact of Timing of Lobectomy on Survival for Clinical Stage IA Lung Squamous Cell Carcinoma.

Journal Article Chest · December 2017 BACKGROUND: Because the relationship between the timing of surgery following diagnosis of lung cancer and survival has not been precisely described, guidelines on what constitutes a clinically meaningful delay of resection of early-stage lung cancer do not ... Full text Link to item Cite

Bedside Tracheostomy on Pediatric ICU Subjects Supported by Extracorporeal Membrane Oxygenation.

Journal Article Respir Care · November 2017 BACKGROUND: Tracheostomy facilitates ambulatory extracorporeal membrane oxygenation (ECMO) as a bridge to recovery or lung transplantation in patients with respiratory failure, yet data on this procedure in this population are lacking. This report describe ... Full text Link to item Cite

Reply to Moris et al.

Journal Article Eur J Cardiothorac Surg · November 1, 2017 Full text Link to item Cite

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.

Journal Article Anesth Analg · October 2017 BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated w ... Full text Open Access Link to item Cite

Adjuvant Chemotherapy Does Not Confer Superior Survival in Patients With Atypical Carcinoid Tumors.

Journal Article Ann Thorac Surg · October 2017 BACKGROUND: Although the use of adjuvant chemotherapy in patients with pathologically node-positive (pN+) atypical carcinoid tumor of the lung is an accepted practice, controversy exists about its use in pathologically node-negative (pN0) patients. Our aim ... Full text Link to item Cite

Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery-A single-center experience of 412 consecutive patients.

Journal Article Clin Transplant · October 2017 PURPOSE: To examine the impact of lung transplantation on gastric motility. METHODS: Adult recipients at a large, single center, who were retrospectively evaluated with solid gastric emptying (SGE) study post-lung transplantation, but had no history of gas ... Full text Link to item Cite

Surgical resection after neoadjuvant chemoradiation for oesophageal adenocarcinoma: what is the optimal timing?

Journal Article Eur J Cardiothorac Surg · September 1, 2017 OBJECTIVES: The purpose of this study was to determine the optimal timing of surgical resection of oesophageal adenocarcinoma following neoadjuvant chemoradiotherapy (nCRT). METHODS: nCRT before resection of oesophageal adenocarcinoma yields improved overa ... Full text Link to item Cite

Elevated HbA1c in donor organs from patients without a diagnosis of diabetes portends worse liver allograft survival.

Journal Article Clin Transplant · September 2017 Recipients of liver allografts from diabetic donors have decreased graft survival. However, limited data exist on the effects of donor HbA1c. We hypothesized that allografts from nondiabetic donors with elevated HbA1c would be associated with decreased sur ... Full text Link to item Cite

Lung transplantation in the most critically-III: forging ahead.

Journal Article J Thorac Dis · September 2017 Lung transplantation is the gold standard therapy for patients with end-stage lung disease. The use of the lung allocation score (LAS) has permitted improved allocation of scarce pulmonary allografts. Recently, Crawford et al. examined the experience in th ... Full text Link to item Cite

Induction chemotherapy for T3N0M0 non-small-cell lung cancer increases the rate of complete resection but does not confer improved survival.

Journal Article Eur J Cardiothorac Surg · August 1, 2017 OBJECTIVES: The objective of this study was to evaluate outcomes of induction therapy prior to an operation in patients with cT3 non-small-cell lung cancer (NSCLC). METHODS: Patients diagnosed with cT3N0M0 NSCLC from 2006 to 2011 in the National Cancer Dat ... Full text Link to item Cite

A national analysis of wedge resection versus stereotactic body radiation therapy for stage IA non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · August 2017 OBJECTIVE: Lobectomy is considered optimal therapy for early-stage non-small cell lung cancer, but sublobar wedge resection and stereotactic body radiation therapy are alternative treatments. This study compared outcomes between wedge resection and stereot ... Full text Link to item Cite

Mortality and Respiratory Failure After Thoracoscopic Lung Biopsy for Interstitial Lung Disease.

Journal Article Ann Thorac Surg · August 2017 BACKGROUND: Surgical lung biopsy contributes to establishing a specific diagnosis among many patients with interstitial lung disease (ILD). The risks of death and respiratory failure associated with elective thoracoscopic surgical lung biopsy, and patient ... Full text Link to item Cite

The association of donor age and survival is independent of ischemic time following deceased donor lung transplantation.

Conference Clin Transplant · July 2017 PURPOSE: Early research suggests prolonged ischemic time in older donor lungs is associated with decreased survival following lung transplantation. The purpose of this study was to determine whether this association holds in the post-lung allocation score ... Full text Link to item Cite

Socioeconomic Status, Not Race, Is Associated With Reduced Survival in Esophagectomy Patients.

Journal Article Ann Thorac Surg · July 2017 BACKGROUND: Black patients with esophageal cancer have worse survival than white patients. This study examines this racial disparity in conjunction with socioeconomic status (SES) and explores whether race-based outcome differences exist using a national d ... Full text Link to item Cite

Elevated donor hemoglobin A1c does not impair early survival in cardiac transplant recipients.

Journal Article Clin Transplant · July 2017 BACKGROUND: Orthotopic heart transplantation (OHT) is the gold-standard therapy for end-stage heart failure. An increasing deficit between suitable allograft availability and clinical demand for OHT exists. The role of donor diabetes mellitus (DM) on post- ... Full text Link to item Cite

Extracorporeal membrane oxygenation following lung transplantation: indications and survival.

Journal Article J Heart Lung Transplant · July 1, 2017 BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is employed to rescue patients with early graft dysfunction after lung transplantation (LTx). Rates of post-LTx ECMO and subsequent outcomes have been limited to single-center reports. METHODS: UNOS re ... Full text Link to item Cite

The utility of 6-minute walk distance in predicting waitlist mortality for lung transplant candidates.

Journal Article J Heart Lung Transplant · July 2017 BACKGROUND: The lung allocation score (LAS) has led to improved organ allocation for transplant candidates. At present, the 6-minute walk distance (6MWD) is treated as a binary categorical variable of whether or not a candidate can walk more than 150 feet ... Full text Link to item Cite

Mitral Regurgitation After Orthotopic Lung Transplantation: Natural History and Impact on Outcomes.

Journal Article J Cardiothorac Vasc Anesth · June 2017 OBJECTIVE: Progression of mitral regurgitation (MR) after orthotopic lung transplantation (OLT) may be an underrecognized phenomenon due to the overlapping symptomatology of pulmonary and valvular disease. Literature evaluating the progression of MR after ... Full text Open Access Link to item Cite

Surgery Versus Optimal Medical Management for N1 Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · June 2017 BACKGROUND: Adjuvant chemotherapy has been demonstrated to improve the outcomes of patients with N1 non-small cell lung cancer. It is unknown whether patients previously thought to have unresectable small cell lung cancer (SCLC) may have tumors amenable to ... Full text Link to item Cite

Long-term survival following kidney transplantation in previous lung transplant recipients-An analysis of the unos registry.

Journal Article Clin Transplant · May 2017 BACKGROUND: Kidney transplantation has been advocated as a therapeutic option in lung recipients who develop end-stage renal disease (ESRD). This analysis outlines patterns of allograft survival following kidney transplantation in previous lung recipients ... Full text Link to item Cite

Clinical predictors and outcome implications of early readmission in lung transplant recipients.

Journal Article J Heart Lung Transplant · May 2017 BACKGROUND: The purpose of this study was to identify risk factors and outcome implications for 30-day hospital readmission in lung transplant recipients. METHODS: We conducted a retrospective cohort study of lung transplant cases from a single, high-volum ... Full text Link to item Cite

Transplant size mismatch in restrictive lung disease.

Journal Article Transpl Int · April 2017 To maximize the benefit of lung transplantation, the effect of size mismatch on survival in lung transplant recipients with restrictive lung disease (RLD) was examined. All single and bilateral RLD lung transplants from 1987 to 2011 in the United Network f ... Full text Link to item Cite

Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.

Journal Article Clin Infect Dis · April 1, 2017 BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recen ... Full text Link to item Cite

The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients.

Journal Article J Thorac Oncol · April 2017 BACKGROUND: This study examined the association of extent of lung resection, pathologic nodal evaluation, and survival for patients with clinical stage I (cT1-2N0M0) adenocarcinoma with lepidic histologic features in the National Cancer Data Base. METHODS: ... Full text Link to item Cite

Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature.

Journal Article Clin Transplant · April 2017 BACKGROUND: Postoperative atrial arrhythmias (AAs) are common after lung transplantation, but studies are mixed regarding their impact on outcomes. We therefore performed this systematic review and meta-analysis to determine whether AAs after lung transpla ... Full text Link to item Cite

Traveling to a High-volume Center is Associated With Improved Survival for Patients With Esophageal Cancer.

Journal Article Ann Surg · April 2017 BACKGROUND: An association between volume and outcomes has been observed for esophagectomy, though little is known about why or how patients choose low- or high-volume centers. The purpose of this study was to evaluate how travel burden and hospital volume ... Full text Link to item Cite

Impact of Diabetes Mellitus and Glycemic Control in Lung Transplant Donors on Recipient Survival

Conference The Journal of Heart and Lung Transplantation · April 2017 Full text Cite

Tough problem, creative solution.

Journal Article J Thorac Cardiovasc Surg · February 2017 Full text Link to item Cite

Extracorporeal membrane oxygenation in the pre and post lung transplant period.

Journal Article Ann Transl Med · February 2017 Evolution in technology has resulted in rapid increase in utilization of extracorporeal membrane oxygenation (ECMO) as a bridge to recovery and/or transplantation. Although there is limited evidence for the use of ECMO, recent improvements in ECMO technolo ... Full text Link to item Cite

Lung Transplant Center Volume Ameliorates Adverse Influence of Prolonged Ischemic Time on Mortality.

Journal Article Am J Transplant · January 2017 The influence of prolonged ischemic time on outcomes after lung transplant is controversial, but no research has investigated ischemic time in the context of center volume. We used data from the United Network for Organ Sharing to estimate the influence of ... Full text Link to item Cite

Medication Nonadherence After Lung Transplantation in Adult Recipients.

Journal Article Ann Thorac Surg · January 2017 BACKGROUND: Our objective was to identify potential avenues for resource allocation and patient advocacy to improve outcomes by evaluating the association between recipient sociodemographic and patient characteristics and medication nonadherence after lung ... Full text Link to item Cite

Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.

Journal Article Front Syst Neurosci · 2017 Each year over 16 million older Americans undergo general anesthesia for surgery, and up to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and POCD are each associated with decreased quality of life, early retirement, incr ... Full text Open Access Link to item Cite

Spontaneously Breathing Extracorporeal Membrane Oxygenation Support Provides the Optimal Bridge to Lung Transplantation.

Journal Article Transplantation · December 2016 BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is being increasingly used as a bridge to lung transplantation. Small, single-institution series have described increased success using ECMO in spontaneously breathing patients compared with patients o ... Full text Link to item Cite

A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · December 2016 BACKGROUND: The long-term survival benefit of lobectomy over sublobar resection for early-stage non-small cell lung cancer must be weighed against a potentially increased risk of perioperative mortality. The objective of the current study was to create a r ... Full text Link to item Cite

Patient Preferences in Treatment Choices for Early-Stage Lung Cancer.

Journal Article Ann Thorac Surg · December 2016 BACKGROUND: Decision-making for lung cancer treatment can be complex because it involves both provider recommendations based on the patient's clinical condition and patient preferences. This study describes the relative importance of several considerations ... Full text Link to item Cite

Staging of Bilateral Lung Transplantation for High-Risk Patients With Interstitial Lung Disease: One Lung at a Time.

Journal Article Am J Transplant · November 2016 The choice of a single or bilateral lung transplant for interstitial lung disease (ILD) is controversial, as surgical risk, long-term survival and organ allocation are competing factors. In an effort to balance risk and benefit, our center adopted a staged ... Full text Link to item Cite

Anesthesia and Perioperative Care for Organ Transplantation

Book · November 1, 2016 Anesthesia and Perioperative Care for Organ Transplantation is for anesthesiologists and critical care physicians; transplantation surgeons; nurse anesthetists; ICU nurses; and trainees.​​ ... Cite

Outcomes of Major Lung Resection After Induction Therapy for Non-Small Cell Lung Cancer in Elderly Patients.

Journal Article Ann Thorac Surg · September 2016 BACKGROUND: This study analyzes the impact of age on perioperative outcomes and long-term survival of patients undergoing surgery after induction chemotherapy for non-small cell lung cancer. METHODS: Short- and long-term outcomes of patients with non-small ... Full text Link to item Cite

Impact of Age on Long-Term Outcomes of Surgery for Malignant Pleural Mesothelioma.

Journal Article Clin Lung Cancer · September 2016 BACKGROUND: Although malignant pleural mesothelioma (MPM) is generally a disease associated with more advanced age, the association of age, treatment, and outcomes has not been well-characterized. We evaluated the impact of age on outcomes in patients with ... Full text Link to item Cite

Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant.

Journal Article Clin Transplant · September 2016 BACKGROUND: Central airway stenosis (CAS) is common after lung transplantation and causes significant post-transplant morbidity. It is often preceded by extensive airway necrosis, related to airway ischemia. Hyperbaric oxygen therapy (HBOT) is useful for i ... Full text Link to item Cite

Induction Chemotherapy is Not Superior to a Surgery-First Strategy for Clinical N1 Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · September 2016 BACKGROUND: Guidelines recommend primary surgical resection for non-small cell lung cancer (NSCLC) patients with clinical N1 disease and adjuvant chemotherapy if nodal disease is confirmed after resection. We tested the hypothesis that induction chemothera ... Full text Link to item Cite

Minimally Invasive Versus Open Esophagectomy for Esophageal Cancer: A Population-Based Analysis.

Journal Article Ann Thorac Surg · August 2016 BACKGROUND: The objective of this study was to evaluate outcomes of minimally invasive approaches to esophagectomy using population-level data. METHODS: Multivariable regression modeling was used to determine predictors associated with the use of minimally ... Full text Link to item Cite

Long-term survival following open versus thoracoscopic lobectomy after preoperative chemotherapy for non-small cell lung cancer.

Journal Article Eur J Cardiothorac Surg · June 2016 OBJECTIVES: Video-assisted thoracoscopic (VATS) lobectomy is increasingly accepted for the management of early-stage non-small cell lung cancer (NSCLC), but its role for locally advanced cancers has not been as well characterized. We compared outcomes of p ... Full text Link to item Cite

Impact of patient selection and treatment strategies on outcomes after lobectomy for biopsy-proven stage IIIA pN2 non-small cell lung cancer.

Journal Article Eur J Cardiothorac Surg · June 2016 OBJECTIVES: We evaluated the impact of patient selection and treatment strategies on long-term outcomes of patients who had lobectomy after induction therapy for stage IIIA pN2 non-small cell lung cancer (NSCLC). METHODS: The impact of various patient sele ... Full text Link to item Cite

Long-term outcomes after lobectomy for non-small cell lung cancer when unsuspected pN2 disease is found: A National Cancer Data Base analysis.

Journal Article J Thorac Cardiovasc Surg · May 2016 OBJECTIVE: There are few studies evaluating whether to proceed with planned resection when a patient with non-small cell lung cancer (NSCLC) unexpectedly is found to have N2 disease at the time of thoracoscopy or thoracotomy. To help guide management of th ... Full text Link to item Cite

Role of Adjuvant Therapy in a Population-Based Cohort of Patients With Early-Stage Small-Cell Lung Cancer.

Journal Article J Clin Oncol · April 1, 2016 PURPOSE: Data on optimal adjuvant therapy after complete resection of small-cell lung cancer (SCLC) are limited, and in particular, there have been no studies evaluating the role of adjuvant chemotherapy, with or without prophylactic cranial irradiation, r ... Full text Link to item Cite

Soluble CD14 and LBP as Markers for Primary Graft Dysfunction

Conference The Journal of Heart and Lung Transplantation · April 2016 Full text Cite

Plasma RIP3 Is Decreased in PGD after Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2016 Full text Cite

High Rates of Post-Transplant Depressive Symptoms Identified Using the CES-D

Conference The Journal of Heart and Lung Transplantation · April 2016 Full text Cite

Redefining Primary Graft Dysfunction after Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2016 Full text Cite

Intravenous Immunoglobulin in Sensitized Lung Transplant Recipients and Early Outcomes

Conference The Journal of Heart and Lung Transplantation · April 2016 Full text Cite

Traveling to a High-volume Center is Associated With Improved Survival for Patients With Esophageal Cancer.

Journal Article Ann Surg · March 15, 2016 BACKGROUND: An association between volume and outcomes has been observed for esophagectomy, though little is known about why or how patients choose low- or high-volume centers. The purpose of this study was to evaluate how travel burden and hospital volume ... Full text Link to item Cite

Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation.

Journal Article Am J Respir Crit Care Med · March 1, 2016 RATIONALE: Central airway stenosis (CAS) after lung transplantation has been attributed in part to chronic airway ischemia; however, little is known about the time course or significance of large airway hypoxia early after transplantation. OBJECTIVES: To e ... Full text Link to item Cite

Impact of Positive Margins on Survival in Patients Undergoing Esophagogastrectomy for Esophageal Cancer.

Journal Article Ann Thorac Surg · March 2016 BACKGROUND: Multimodality treatment that includes esophagogastrectomy may represent the best option for curing accurately staged patients with esophageal cancer. We analyzed the impact of incomplete resection on outcomes after esophagogastrectomy for esoph ... Full text Link to item Cite

Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk.

Journal Article Am J Transplant · March 2016 The authors previously identified plasma plasminogen activator inhibitor-1 (PAI-1) level as a quantitative lung injury biomarker in primary graft dysfunction (PGD). They hypothesized that plasma levels of PAI-1 used as a quantitative trait could facilitate ... Full text Link to item Cite

Use and Outcomes of Minimally Invasive Lobectomy for Stage I Non-Small Cell Lung Cancer in the National Cancer Data Base.

Journal Article Ann Thorac Surg · March 2016 BACKGROUND: Previous studies have raised concerns that video-assisted thoracoscopic (VATS) lobectomy may compromise nodal evaluation. The advantages or limitations of robotic lobectomy have not been thoroughly evaluated. METHODS: Perioperative outcomes and ... Full text Link to item Cite

Lung transplantation at Duke.

Journal Article J Thorac Dis · March 2016 Lung transplantation represents the gold-standard therapy for patients with end-stage lung disease. Utilization of this therapy continues to rise. The Lung Transplant Program at Duke University Medical Center was established in 1992, and since that time ha ... Full text Link to item Cite

Impact of donor and recipient hepatitis C status in lung transplantation.

Journal Article J Heart Lung Transplant · February 2016 BACKGROUND: Studies of lung transplantation in the setting of donors or recipients with hepatitis C virus (HCV) have been limited but have raised concerns about outcomes associated with this infection. METHODS: Lung transplant cases in the United Network f ... Full text Link to item Cite

Sublobar Resection for Clinical Stage IA Non-small-cell Lung Cancer in the United States.

Journal Article Clin Lung Cancer · January 2016 BACKGROUND: This study evaluated the use of lobectomy and sublobar resection for clinical stage IA non-small-cell lung cancer (NSCLC) in the National Cancer Data Base (NCDB). METHODS: The NCDB from 2003 to 2011 was analyzed to determine factors associated ... Full text Link to item Cite

Adding radiation to induction chemotherapy does not improve survival of patients with operable clinical N2 non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · December 2015 OBJECTIVE: Radiotherapy is commonly used in induction regimens for patients with non-small cell lung cancer with operable mediastinal nodal disease, although evidence has not shown a benefit over induction chemotherapy alone. We compared outcomes between i ... Full text Link to item Cite

The impact of tumor size on the association of the extent of lymph node resection and survival in clinical stage I non-small cell lung cancer.

Journal Article Lung Cancer · December 2015 INTRODUCTION: Lymph node evaluation for node-negative non-small cell lung cancer (NSCLC) is associated with long-term survival but it is not clear if smaller tumors require as extensive a pathologic nodal assessment as larger tumors. This study evaluated t ... Full text Link to item Cite

What Is the Optimal Transplant for Older Patients With Idiopathic Pulmonary Fibrosis?

Journal Article Ann Thorac Surg · November 2015 BACKGROUND: There is controversy regarding the optimal type of lung transplant--single orthotopic lung transplantation (SOLT) versus bilateral orthotopic lung transplantation (BOLT)--for patients with idiopathic pulmonary fibrosis. We performed this study ... Full text Link to item Cite

The utility of preoperative six-minute-walk distance in lung transplantation.

Journal Article Am J Respir Crit Care Med · October 1, 2015 RATIONALE: The use of 6-minute-walk distance (6MWD) as an indicator of exercise capacity to predict postoperative survival in lung transplantation has not previously been well studied. OBJECTIVES: To evaluate the association between 6MWD and postoperative ... Full text Link to item Cite

Wedge Resection vs Segmentectomy for Patients with T1A N0 Non-Small Cell Lung Cancer

Journal Article JOURNAL OF THORACIC ONCOLOGY · September 1, 2015 Link to item Cite

Impact of Pulmonary Function Measurements on Long-Term Survival After Lobectomy for Stage I Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · July 2015 BACKGROUND: Pulmonary function tests predict respiratory complications after lobectomy. We evaluated the impact of pulmonary function measurements on long-term survival after lobectomy for stage I non-small cell lung cancer. METHODS: The relationship betwe ... Full text Link to item Cite

Adjuvant Chemotherapy After Lobectomy for T1-2N0 Non-Small Cell Lung Cancer: Are the Guidelines Supported?

Journal Article J Natl Compr Canc Netw · June 2015 BACKGROUND: Evidence guiding adjuvant chemotherapy (AC) use after lobectomy for stage I non-small cell lung cancer (NSCLC) is limited. This study evaluated the impact of AC use and tumor size on outcomes using a large, nationwide cancer database. METHODS: ... Full text Link to item Cite

Lung Transplantation from Donors With Kidney Disease

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2015 Link to item Cite

Factors Predicting Survival in Early Lung Retransplantation

Conference The Journal of Heart and Lung Transplantation · April 2015 Full text Cite

Single-lung transplantation in the United States: what happens to the other lung?

Conference J Heart Lung Transplant · January 2015 BACKGROUND: This study assessed treatment patterns and examined organ utilization in the setting of single-lung transplantation (SLT). METHODS: The United Network for Organ Sharing database was queried for all SLTs performed from 1987 to 2011. Trends in ut ... Full text Link to item Cite

Induction chemoradiation therapy prior to esophagectomy is associated with superior long-term survival for esophageal cancer.

Journal Article Dis Esophagus · 2015 The purpose of this study was to examine the role of induction chemoradiation in the treatment of potentially resectable locally advanced (T2-3N0 and T1-3N+) esophageal cancer utilizing a large national database. The National Cancer Data Base (NCDB) was qu ... Full text Link to item Cite

Reflux and allograft dysfunction: is there a connection?

Journal Article Thorac Surg Clin · 2015 Despite improving outcomes following lung transplantation, chronic rejection continues to limit survival. The predominant form of chronic rejection, bronchiolitis obliterans syndrome, has been associated with multiple etiologies including aspiration from g ... Full text Link to item Cite

Differential outcomes with early and late repeat transplantation in the era of the lung allocation score.

Journal Article Ann Thorac Surg · December 2014 BACKGROUND: Rates of repeat lung transplantation have increased since implementation of the lung allocation score (LAS). The purpose of this study is to compare survival between repeat (ReTx) and primary (LTx) lung transplant recipients in the LAS era. MET ... Full text Link to item Cite

The effect of prior pneumonectomy or lobectomy on subsequent lung transplantation.

Journal Article Ann Thorac Surg · December 2014 BACKGROUND: Lung transplantation in patients with prior lobectomy or pneumonectomy is not well understood. Using the United Network for Organ Sharing (UNOS) database, we address the impact of prior major lung resection on lung transplantation outcomes. MET ... Full text Link to item Cite

Acute kidney injury after ex vivo lung perfusion (EVLP).

Journal Article Transplant Proc · December 2014 BACKGROUND: Ex vivo lung perfusion (EVLP) identifies viability for marginal organs but complicates and lengthens lung transplantation surgery. Preliminary evidence supports equivalency for EVLP-assisted versus traditional (non-EVLP) procedures regarding gr ... Full text Link to item Cite

Induction therapy does not improve survival for clinical stage T2N0 esophageal cancer.

Journal Article J Thorac Oncol · August 2014 INTRODUCTION: This study compared survival after initial treatment with esophagectomy as primary therapy to induction therapy followed by esophagectomy for patients with clinical T2N0 (cT2N0) esophageal cancer in the National Cancer Database (NCDB). METHOD ... Full text Link to item Cite

Bridge to lung transplantation and rescue post-transplant: the expanding role of extracorporeal membrane oxygenation.

Journal Article J Thorac Dis · August 2014 Over the last several decades, the growth of lung transplantation has been hindered by a much higher demand for donor lungs than can be supplied, leading to considerable waiting time and mortality among patients waiting for transplant. This has led to the ... Full text Link to item Cite

Alterations in Esophageal Function Following Lung Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2014 Link to item Cite

Incidence of Delayed Gastric Emptying Following Lung Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2014 Link to item Cite

Preoperative mild-to-moderate coronary artery disease does not affect long-term outcomes of lung transplantation.

Conference Transplantation · May 27, 2014 BACKGROUND: Coronary artery disease has a high prevalence among lung transplant recipients and has historically been a contraindication to transplant at many institutions. In patients with mild-to-moderate coronary artery disease (Mod-CAD) undergoing lung ... Full text Link to item Cite

Donor and Recipient Hepatitis C Status in Lung Transplant

Conference The Journal of Heart and Lung Transplantation · April 2014 Full text Cite

Donor Diabetes and Lung Transplant: Does It Matter?

Conference The Journal of Heart and Lung Transplantation · April 2014 Full text Cite

Cryoanalgesia Complements Thoracic Epidural Use Following Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2014 Full text Cite

Perioperative Venous Thromboembolism Prophylaxis in Lung Transplant Patients

Conference The Journal of Heart and Lung Transplantation · April 2014 Full text Cite

Lung Transplantation Procedure and Surgical Technique

Chapter · January 1, 2014 Subtle refinements in the surgical technique have contributed to the significant improvements in the early survival of lung transplant recipients. Current survival data from our center demonstrate 30-day and 1-year survivals of 98% and 89%, respectively. T ... Full text Cite

Lung transplantation

Chapter · December 15, 2013 Cite

Coronary revascularization in lung transplant recipients with concomitant coronary artery disease.

Conference Am J Transplant · November 2013 Coronary artery disease (CAD) is not uncommon among lung transplant candidates. Several small, single-center series have suggested that short-term outcomes are acceptable in selected patients who undergo coronary revascularization prior to, or concomitant ... Full text Link to item Cite

Extracorporeal membrane oxygenation post lung transplantation.

Journal Article Curr Opin Organ Transplant · October 2013 PURPOSE OF REVIEW: Extracorporeal membrane oxygenation (ECMO) has been employed as a management strategy to support the failing pulmonary allograft following lung transplantation. We review the indications, technical considerations, management strategies, ... Full text Link to item Cite

Use of lung allografts from brain-dead donors after cardiopulmonary arrest and resuscitation.

Journal Article Am J Respir Crit Care Med · August 15, 2013 RATIONALE: Patients who progress to brain death after resuscitation from cardiac arrest have been hypothesized to represent an underused source of potential organ donors; however, there is a paucity of data regarding the viability of lung allografts after ... Full text Link to item Cite

Active rehabilitation during extracorporeal membrane oxygenation as a bridge to lung transplantation.

Journal Article Respir Care · August 2013 BACKGROUND: Patients with end-stage lung disease often progress to critical illness, which dramatically reduces their chance of survival following lung transplantation. Pre-transplant deconditioning has a significant impact on outcomes for all lung transpl ... Full text Link to item Cite

Optimizing the Estimation of Renal Function in Lung Transplant Candidates

Conference The Journal of Heart and Lung Transplantation · April 2013 Full text Cite

In the face of chronic aspiration, prolonged ischemic time exacerbates obliterative bronchiolitis in rat pulmonary allografts.

Journal Article Am J Transplant · November 2012 Aspiration of gastric fluid into the lung mediates the development of obliterative bronchiolitis (OB) in orthotopic WKY-to-F344 rat pulmonary transplants that have been subjected to immunosuppression with cyclosporine. However, the contribution of ischemic ... Full text Link to item Cite

Gastroesophageal reflux disease-induced aspiration injury following lung transplantation.

Journal Article Curr Opin Organ Transplant · October 2012 PURPOSE OF REVIEW: Chronic allograft failure remains the leading cause of late mortality following lung transplantation. Considerable evidence demonstrates a relationship between gastroesophageal reflux disease (GERD) induced allograft injury and bronchiol ... Full text Link to item Cite

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Other Annals of Thoracic Surgery · August 1, 2012 Full text Cite

87 Coronary Revascularization in Lung Transplant Recipients with Concomitant Coronary Artery Disease

Journal Article The Journal of Heart and Lung Transplantation · April 2012 Full text Cite

85 Lung Transplantation Is an Effective Treatment Option for Patients over the Age of 70

Conference The Journal of Heart and Lung Transplantation · April 2012 Full text Cite

Improved survival but marginal allograft function in patients treated with extracorporeal membrane oxygenation after lung transplantation.

Journal Article Ann Thorac Surg · February 2012 BACKGROUND: Previous reports demonstrate that 1-year survival is severely compromised in patients with severe primary graft dysfunction (PGD) after lung transplantation. We examined if advances in extracorporeal membrane oxygenation (ECMO) support, includi ... Full text Link to item Cite

The trade-off of using positive-smoking donor lungs.

Journal Article Semin Thorac Cardiovasc Surg · 2012 The existing donor supply is unable to meet the demand of patients waiting for lung transplantation. A recent article explores the consequences of donor smoking on post-transplant survival as well as the potential effect of excluding such donors from contr ... Full text Link to item Cite

Fundoplication after lung transplantation prevents the allograft dysfunction associated with reflux.

Journal Article Ann Thorac Surg · August 2011 BACKGROUND: Gastroesophageal reflux disease (GERD) in lung recipients is associated with decreased survival and attenuated allograft function. This study evaluates fundoplication in preventing GERD-related allograft dysfunction. METHODS: Prospectively coll ... Full text Link to item Cite

Surgical site infections following bariatric surgery in community hospitals: a weighty concern?

Journal Article Obes Surg · July 2011 BACKGROUND: Although obesity is a well-known risk factor for surgical site infection (SSI), specific risk factors for SSI among obese patients undergoing bariatric surgery (BS) have not been well-defined. METHODS: We performed a prospective cohort study on ... Full text Link to item Cite

Thoracoscopic lobectomy: the gold standard for early-stage lung cancer?

Journal Article Ann Thorac Surg · June 2010 Primary lung cancers remain the most lethal of all the malignancies, predicted to account for nearly 160,000 deaths and 220,000 new diagnoses in 2009. The cornerstone of therapy for early-stage lung cancer is surgical resection by lobectomy with concomitan ... Full text Link to item Cite

Multiseptate gallbladder.

Journal Article J Gastrointest Surg · September 2009 INTRODUCTION: Multiseptate gallbladder is a rare congenital condition that may be asymptomatic or may lead to symptoms consistent with biliary colic, even in the absence of cholelithiasis. DISCUSSION: We present the case of a 19-year-old female who underwe ... Full text Link to item Cite

Aprotinin's effect on blood product transfusion in off-pump bilateral lung transplantation.

Journal Article Interact Cardiovasc Thorac Surg · January 2009 In lung transplants necessitating cardiopulmonary bypass (CPB), aprotinin has been shown to decrease transfusion requirements. More recently, off-pump transplantation has become the standard of care. The efficacy of aprotinin use in this population has yet ... Full text Link to item Cite

Lung transplantation at Duke University.

Journal Article Clin Transpl · 2009 Clinical lung transplantation continues to grow worldwide. Advances in donor selection and management have been critical to support the expanded growth of lung transplant as a therapeutic option for patients with advanced lung disease. In recent years, all ... Link to item Cite

Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants.

Journal Article Am J Transplant · August 2008 Long-term survival of a pulmonary allograft is currently hampered by obliterative bronchiolitis (OB), a form of chronic rejection that is unique to lung transplantation. While tracheobronchial aspiration from gastroesophageal reflux disease (GERD) has clin ... Full text Link to item Cite

Rabbit anti-thymocyte globulin induction therapy does not prolong survival after lung transplantation.

Journal Article J Heart Lung Transplant · May 2008 BACKGROUND: Lung transplant survival is limited by the development of bronchiolitis obliterans syndrome (BOS). The strongest risk factor for BOS is acute rejection (AR). We have previously shown that rabbit anti-thymocyte globulin (RATG) induction therapy ... Full text Link to item Cite

Surgical volume and the risk of surgical site infection in community hospitals: size matters.

Journal Article Ann Surg · February 2008 OBJECTIVE: To determine if surgical volume affects the risk of surgical site infections (SSI) in community hospitals. BACKGROUND: The utility of public reporting and the optimal methods to employ when reporting SSI rates remain controversial and contentiou ... Full text Link to item Cite

Characterization of the innate immune response to chronic aspiration in a novel rodent model.

Journal Article Respir Res · November 27, 2007 BACKGROUND: Although chronic aspiration has been associated with several pulmonary diseases, the inflammatory response has not been characterized. A novel rodent model of chronic aspiration was therefore developed in order to investigate the resulting inna ... Full text Link to item Cite

380: Chronic aspiration in lung allotransplantation induces a donor-specific hyperimmune state

Conference The Journal of Heart and Lung Transplantation · February 2007 Full text Cite

157: Perioperative predictors of renal failure following off-pump primary double lung transplantation

Conference The Journal of Heart and Lung Transplantation · February 2007 Full text Cite

Lung transplantation at Duke University Medical Center.

Journal Article Clin Transpl · 2007 Lung transplantation has undergone remarkable changes in clinical practice to address the higher rate of rejection and mortality. Our protocols include increased immunosuppression and strategies to address non-alloimmune injury, including GER. New and inno ... Link to item Cite

Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant.

Journal Article J Heart Lung Transplant · November 2006 BACKGROUND: Cytokine polymorphisms are inconsistently associated with transplant rejection and other adverse outcomes. To address this controversy, we evaluated cytokine single nucleotide polymorphisms (SNPs) in a lung transplant cohort. METHODS: All patie ... Full text Link to item Cite

Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies.

Journal Article Transplantation · April 15, 2006 BACKGROUND: Antidonor HLA-specific antibodies have been associated with hyperacute rejection and primary graft failure in lung transplant recipients. Thus, transplant candidates with HLA-specific antibodies generally undergo prospective crossmatching to ex ... Full text Link to item Cite

Successful bilateral lung transplant outcomes in recipients 61 years of age and older.

Journal Article Transplantation · March 27, 2006 BACKGROUND: Controversy exists regarding the optimal use of bilateral lung transplant (BLT) in older recipients in diseases where either single or bilateral transplant is appropriate. International Society for Heart and Lung Transplant (ISHLT) guidelines s ... Full text Link to item Cite

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Conference The Journal of Heart and Lung Transplantation · February 2006 Full text Cite

Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation.

Journal Article J Thorac Cardiovasc Surg · January 2006 OBJECTIVE: Emerging clinical evidence suggests that gastroesophageal reflux disease is associated with pulmonary allograft dysfunction. In this study, we used a model of rat lung transplantation to test the hypothesis that chronic aspiration of gastric con ... Full text Link to item Cite

Improved results treating lung allograft failure with venovenous extracorporeal membrane oxygenation.

Journal Article Ann Thorac Surg · November 2005 BACKGROUND: Primary graft failure remains a significant source of mortality after lung transplantation. Extracorporeal membrane oxygenation (ECMO) provides treatment for affected recipients. We hypothesized that venovenous membrane oxygenation provides a s ... Full text Link to item Cite

Hepatitis B core antibody positive donors as a safe and effective therapeutic option to increase available organs for lung transplantation.

Journal Article Transplantation · August 15, 2005 BACKGROUND: The use of hepatitis B core antibody (HBcAb+) and hepatitis C antibody (HCV Ab+) positive donors represents one strategy to increase available donor organs, but this remains controversial because of concern for viral transmission to recipients. ... Full text Link to item Cite

Antireflux surgery in the setting of lung transplantation: strategies for treating gastroesophageal reflux disease in a high-risk population.

Journal Article Thorac Surg Clin · August 2005 In lung transplant recipients, GERD is associated with increased incidence of acute rejection, earlier onset of chronic rejection, and higher mortality. Surgical treatment of GERD in lung recipients seems to prevent early allograft dysfunction and improve ... Full text Link to item Cite

Utility of peritransplant and rescue intravenous immunoglobulin and extracorporeal immunoadsorption in lung transplant recipients sensitized to HLA antigens.

Journal Article Hum Immunol · April 2005 The role of anti-human leukocyte antigen (HLA) antibodies in lung transplantation is not fully clear. The presence of pretransplant third-party anti-HLA antibodies or the development of de novo anti-HLA antibodies has been associated with acute posttranspl ... Full text Link to item Cite

Nonalloimmune mechanisms contributing to lung allograft dysfunction: A potential role for gastroesophageal reflux disease

Journal Article Current Opinion in Organ Transplantation · 2005 Purpose of review: Lung allograft dysfunction and bronchiolitis obliterans syndrome remain the primary impediment to long-term survival after lung transplantation. Chronic aspiration resulting from gastroesophageal reflux disease is particularly common in ... Full text Cite

Surgical considerations in lung transplantation: transplant operation and early postoperative management.

Journal Article Respir Care Clin N Am · December 2004 During the last 20 years improvements in perioperative care have led to improved outcomes for lung transplant recipients. Although uncommon, technical complications can be the source of significant morbidity and mortality. Infections and ischemia-reperfusi ... Full text Link to item Cite

Role of cellular immunity in GERD-associated bronchiolitis obliterans syndrome

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · September 1, 2004 Link to item Cite

Neoadjuvant chemoradiation for rectal cancer: analysis of clinical outcomes from a 13-year institutional experience.

Journal Article Ann Surg · June 2001 OBJECTIVE: To examine clinical outcomes in patients receiving neoadjuvant chemoradiation for locally advanced rectal adenocarcinoma. SUMMARY BACKGROUND DATA: Preoperative radiation therapy, either alone or in combination with 5-fluorouracil-based chemother ... Full text Link to item Cite

On the stimulating capacity of human leukemic REH cells in a mixed lymphocyte culture.

Journal Article Biomed Biochim Acta · 1986 In contrast to earlier studies, the presence of a stimulating capacity of cultured leukemic REH cells in a mixed lymphocyte culture is demonstrated. Supernatants of REH cells in a 1:10 final dilution were found to inhibit lymphocyte proliferation by about ... Link to item Cite

Central Cannulation as a Viable Alternative to Peripheral Cannulation in Extracorporeal Membrane Oxygenation.

Journal Article Semin Thorac Cardiovasc Surg Arterial cannulation for veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) is most commonly established via the aorta, axillary, or femoral vessels, yet their inherent complications are not well characterized. The purpose of this study was to c ... Full text Link to item Cite

Is the Third Time the Charm? Evaluating Rehabilitation Differences in Third Lung Transplant Recipients

Conference Purpose Chronic lung allograft dysfunction (CLAD) is the leading cause of graft failure causing significant morbidity and mortality. Re-transplantation (L2Tx) after CLAD is historically associated with complicated peri-operative and post-operative courses ... Cite

Implications of the Composite Allocation Score System for Lung Transplantation in the United States: Review of the New System.

Journal Article Semin Thorac Cardiovasc Surg Due to criticism regarding undue adherence to fixed geographic boundaries, the Lung Allocation Score system was recently replaced by the more holistic allocation via continuous distribution. This review highlights the historical evolution of US lung alloca ... Full text Link to item Cite