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NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

Publication ,  Journal Article
SenNet Consortium,
Published in: Nat Aging
December 2022

Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretory phenotype are vast, yet ill characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and their detection a priority. The Cellular Senescence Network (SenNet), a National Institutes of Health Common Fund initiative, was established to address this need. The goal of SenNet is to map SnCs across the human lifespan to advance diagnostic and therapeutic approaches to improve human health. State-of-the-art methods will be applied to identify, define and map SnCs in 18 human tissues. A common coordinate framework will integrate data to create four-dimensional SnC atlases. Other key SenNet deliverables include innovative tools and technologies to detect SnCs, new SnC biomarkers and extensive public multi-omics datasets. This Perspective lays out the impetus, goals, approaches and products of SenNet.

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Published In

Nat Aging

DOI

EISSN

2662-8465

Publication Date

December 2022

Volume

2

Issue

12

Start / End Page

1090 / 1100

Location

United States

Related Subject Headings

  • United States
  • Longevity
  • Humans
  • Cellular Senescence
  • Biomarkers
  • 3202 Clinical sciences
 

Citation

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SenNet Consortium, . (2022). NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. Nat Aging, 2(12), 1090–1100. https://doi.org/10.1038/s43587-022-00326-5
SenNet Consortium, Junjie. “NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.Nat Aging 2, no. 12 (December 2022): 1090–1100. https://doi.org/10.1038/s43587-022-00326-5.
SenNet Consortium, Junjie. “NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.Nat Aging, vol. 2, no. 12, Dec. 2022, pp. 1090–100. Pubmed, doi:10.1038/s43587-022-00326-5.

Published In

Nat Aging

DOI

EISSN

2662-8465

Publication Date

December 2022

Volume

2

Issue

12

Start / End Page

1090 / 1100

Location

United States

Related Subject Headings

  • United States
  • Longevity
  • Humans
  • Cellular Senescence
  • Biomarkers
  • 3202 Clinical sciences