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Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant.

Publication ,  Journal Article
Mahmood, K; Kraft, BD; Glisinski, K; Hartwig, MG; Harlan, NP; Piantadosi, CA; Shofer, SL
Published in: Clin Transplant
September 2016

BACKGROUND: Central airway stenosis (CAS) is common after lung transplantation and causes significant post-transplant morbidity. It is often preceded by extensive airway necrosis, related to airway ischemia. Hyperbaric oxygen therapy (HBOT) is useful for ischemic grafts and may reduce the development of CAS. METHODS: The purpose of this study was to determine whether HBOT could be safely administered to lung transplant patients with extensive necrotic airway plaques. Secondarily, we assessed any effects of HBOT on the incidence and severity of CAS. Patients with extensive necrotic airway plaques within 1-2 months after lung transplantation were treated with HBOT along with standard care. These patients were compared with a contemporaneous reference group with similar plaques who did not receive HBOT. RESULTS: Ten patients received HBOT for 18.5 (interquartile range, IQR 11-20) sessions, starting at 40.5 (IQR 34-54) days after transplantation. HBOT was well tolerated. Incidence of CAS was similar between HBOT-treated patients and reference patients (70% vs 87%, respectively; P=.34), but fewer stents were required in HBOT patients (10% vs 56%, respectively; P=.03). CONCLUSIONS: This pilot study is the first to demonstrate HBOT safety in patients who develop necrotic airway plaques after lung transplantation. HBOT may reduce the need for airway stent placement in patients with CAS.

Duke Scholars

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Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

September 2016

Volume

30

Issue

9

Start / End Page

1134 / 1139

Location

Denmark

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Surgery
  • Postoperative Complications
  • Pilot Projects
  • North Carolina
  • Middle Aged
  • Male
  • Lung Transplantation
  • Incidence
 

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Mahmood, K., Kraft, B. D., Glisinski, K., Hartwig, M. G., Harlan, N. P., Piantadosi, C. A., & Shofer, S. L. (2016). Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant. Clin Transplant, 30(9), 1134–1139. https://doi.org/10.1111/ctr.12798
Mahmood, Kamran, Bryan D. Kraft, Kristen Glisinski, Matthew G. Hartwig, Nicole P. Harlan, Claude A. Piantadosi, and Scott L. Shofer. “Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant.Clin Transplant 30, no. 9 (September 2016): 1134–39. https://doi.org/10.1111/ctr.12798.
Mahmood K, Kraft BD, Glisinski K, Hartwig MG, Harlan NP, Piantadosi CA, et al. Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant. Clin Transplant. 2016 Sep;30(9):1134–9.
Mahmood, Kamran, et al. “Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant.Clin Transplant, vol. 30, no. 9, Sept. 2016, pp. 1134–39. Pubmed, doi:10.1111/ctr.12798.
Mahmood K, Kraft BD, Glisinski K, Hartwig MG, Harlan NP, Piantadosi CA, Shofer SL. Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant. Clin Transplant. 2016 Sep;30(9):1134–1139.
Journal cover image

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

September 2016

Volume

30

Issue

9

Start / End Page

1134 / 1139

Location

Denmark

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Surgery
  • Postoperative Complications
  • Pilot Projects
  • North Carolina
  • Middle Aged
  • Male
  • Lung Transplantation
  • Incidence