Scholars@Duke
Ariel Spurrier

Ariel Spurrier

Research Scholar
Molecular Genetics and Microbiology
meghan.spurrier@duke.edu
3200 MSRBIII, Durham, NC 27705
3200 MSRBIII, 3 Genome Court, Durham, NC 27705

Selected Publications

B cell-expressed CD1d promotes MPL/TDCM lipid emulsion adjuvant effects in polysaccharide vaccines.

Journal Article Journal of immunology (Baltimore, Md. : 1950) · July 2025 T cell-independent type 2 antigens (TI-2 Ags), such as pneumococcal polysaccharides, elicit weak immunoglobulin G (IgG) responses and are refractive to boosting. Overcoming this challenge is critical for improving vaccines. Previously, we demonstrated a li ... Full text Cite

Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions.

Journal Article J Virol · November 19, 2024 In early 2024, a clade 2.3.4.4b high pathogenic H5N1 avian influenza virus was detected in dairy cows and humans in the United States. Since then, it has spread to herds in at least 13 states and caused symptomatic disease in at least fifteen people. To fa ... Full text Link to item Cite

Vaccination with antigenically complex hemagglutinin mixtures confers broad protection from influenza disease.

Journal Article Sci Transl Med · May 2024 Current seasonal influenza virus vaccines induce responses primarily against immunodominant but highly plastic epitopes in the globular head of the hemagglutinin (HA) glycoprotein. Because of viral antigenic drift at these sites, vaccines need to be update ... Full text Link to item Cite

Type I IFN Receptor Signaling on B Cells Promotes Antibody Responses to Polysaccharide Antigens.

Journal Article Journal of immunology (Baltimore, Md. : 1950) · January 2023 We previously reported monophosphoryl lipid A (MPL) and synthetic cord factor trehalose-6,6'-dicorynomycolate (TDCM) significantly increase Ab responses to T cell-independent type 2 Ags (TI-2 Ags) in a manner dependent on B cell-intrinsic TLR4 expression, ... Full text Cite

The PD-1 Regulatory Axis Inhibits T Cell-Independent B Cell Memory Generation and Reactivation.

Journal Article Journal of immunology (Baltimore, Md. : 1950) · October 2021 The inability of T cell-independent type 2 (TI-2) Ags to induce recall responses is a poorly understood facet of humoral immunity, yet critically important for improving vaccines. Using normal and VHB1-8 transgenic mice, we demonstrate that B ce ... Full text Cite

B Cell Subsets Differentially Contribute to the T Cell-Independent Memory Pool.

Journal Article Journal of immunology (Baltimore, Md. : 1950) · November 2020 The roles distinct B cell subsets play in clonal expansion, isotype switching, and memory B cell differentiation in response to T cell-independent type 2 Ags (TI-2 Ags) has been understudied. Using sorted B cells from VHB1-8 knock-in mice, we ev ... Full text Cite

A new species of Zephyranthes (Amaryllidaceae) from Mexico

Journal Article Novon · December 10, 2015 The new species Zephyranthes stellatorosea G. Lom. Sm., Spurrier, Flagg & Espejo (Amaryllidaceae) is described from Puebla and Hidalgo, Mexico, and figures are included. This species has affinities with Z. lindleyana Herb. and Z. macrosiphon Baker; however ... Full text Cite