Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions.
Publication
, Journal Article
Trimarco, JD; Spurrier, MA; Skavicus, S; Luo, Z; Dutta, M; Janowska, K; Acharya, P; Heaton, BE; Heaton, NS
Published in: J Virol
November 19, 2024
In early 2024, a clade 2.3.4.4b high pathogenic H5N1 avian influenza virus was detected in dairy cows and humans in the United States. Since then, it has spread to herds in at least 13 states and caused symptomatic disease in at least fifteen people. To facilitate rapid testing of existing and novel countermeasures, here, we report the development of an H5N1 viral reverse genetic system, its use to produce fluorescent and bioluminescent variant strains, and their utility in high-throughput evaluation of antiviral interventions.
Duke Scholars
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
November 19, 2024
Volume
98
Issue
11
Start / End Page
e0138524
Location
United States
Related Subject Headings
- Virology
- Reverse Genetics
- Orthomyxoviridae Infections
- Madin Darby Canine Kidney Cells
- Luminescent Measurements
- Influenza, Human
- Influenza A Virus, H5N1 Subtype
- Humans
- Cattle Diseases
- Cattle
Citation
APA
Chicago
ICMJE
MLA
NLM
Trimarco, J. D., Spurrier, M. A., Skavicus, S., Luo, Z., Dutta, M., Janowska, K., … Heaton, N. S. (2024). Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions. J Virol, 98(11), e0138524. https://doi.org/10.1128/jvi.01385-24
Trimarco, Joseph D., M Ariel Spurrier, Samantha Skavicus, Zhaochen Luo, Moumita Dutta, Katarzyna Janowska, Priyamvada Acharya, Brook E. Heaton, and Nicholas S. Heaton. “Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions.” J Virol 98, no. 11 (November 19, 2024): e0138524. https://doi.org/10.1128/jvi.01385-24.
Trimarco JD, Spurrier MA, Skavicus S, Luo Z, Dutta M, Janowska K, et al. Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions. J Virol. 2024 Nov 19;98(11):e0138524.
Trimarco, Joseph D., et al. “Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions.” J Virol, vol. 98, no. 11, Nov. 2024, p. e0138524. Pubmed, doi:10.1128/jvi.01385-24.
Trimarco JD, Spurrier MA, Skavicus S, Luo Z, Dutta M, Janowska K, Acharya P, Heaton BE, Heaton NS. Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions. J Virol. 2024 Nov 19;98(11):e0138524.
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
November 19, 2024
Volume
98
Issue
11
Start / End Page
e0138524
Location
United States
Related Subject Headings
- Virology
- Reverse Genetics
- Orthomyxoviridae Infections
- Madin Darby Canine Kidney Cells
- Luminescent Measurements
- Influenza, Human
- Influenza A Virus, H5N1 Subtype
- Humans
- Cattle Diseases
- Cattle