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Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions.

Publication ,  Journal Article
Trimarco, JD; Spurrier, MA; Skavicus, S; Luo, Z; Dutta, M; Janowska, K; Acharya, P; Heaton, BE; Heaton, NS
Published in: Journal of virology
November 2024

In early 2024, a clade 2.3.4.4b high pathogenic H5N1 avian influenza virus was detected in dairy cows and humans in the United States. Since then, it has spread to herds in at least 13 states and caused symptomatic disease in at least fifteen people. To facilitate rapid testing of existing and novel countermeasures, here, we report the development of an H5N1 viral reverse genetic system, its use to produce fluorescent and bioluminescent variant strains, and their utility in high-throughput evaluation of antiviral interventions.

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Published In

Journal of virology

DOI

EISSN

1098-5514

ISSN

0022-538X

Publication Date

November 2024

Volume

98

Issue

11

Start / End Page

e0138524

Related Subject Headings

  • Virology
  • Reverse Genetics
  • Orthomyxoviridae Infections
  • Madin Darby Canine Kidney Cells
  • Luminescent Measurements
  • Influenza, Human
  • Influenza A Virus, H5N1 Subtype
  • Humans
  • Cattle Diseases
  • Cattle
 

Citation

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Trimarco, J. D., Spurrier, M. A., Skavicus, S., Luo, Z., Dutta, M., Janowska, K., … Heaton, N. S. (2024). Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions. Journal of Virology, 98(11), e0138524. https://doi.org/10.1128/jvi.01385-24
Trimarco, Joseph D., M Ariel Spurrier, Samantha Skavicus, Zhaochen Luo, Moumita Dutta, Katarzyna Janowska, Priyamvada Acharya, Brook E. Heaton, and Nicholas S. Heaton. “Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions.Journal of Virology 98, no. 11 (November 2024): e0138524. https://doi.org/10.1128/jvi.01385-24.
Trimarco JD, Spurrier MA, Skavicus S, Luo Z, Dutta M, Janowska K, et al. Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions. Journal of virology. 2024 Nov;98(11):e0138524.
Trimarco, Joseph D., et al. “Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions.Journal of Virology, vol. 98, no. 11, Nov. 2024, p. e0138524. Epmc, doi:10.1128/jvi.01385-24.
Trimarco JD, Spurrier MA, Skavicus S, Luo Z, Dutta M, Janowska K, Acharya P, Heaton BE, Heaton NS. Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions. Journal of virology. 2024 Nov;98(11):e0138524.

Published In

Journal of virology

DOI

EISSN

1098-5514

ISSN

0022-538X

Publication Date

November 2024

Volume

98

Issue

11

Start / End Page

e0138524

Related Subject Headings

  • Virology
  • Reverse Genetics
  • Orthomyxoviridae Infections
  • Madin Darby Canine Kidney Cells
  • Luminescent Measurements
  • Influenza, Human
  • Influenza A Virus, H5N1 Subtype
  • Humans
  • Cattle Diseases
  • Cattle