Scholars@Duke
Nancy Bates Allen

Nancy Bates Allen

Professor Emeritus of Medicine
Medicine, Rheumatology and Immunology
nancy.allen@duke.edu
Duke Box 3440, Durham, NC 27710
4010 Purple Zone Hosp South, 201 Trent Dr., Durham, NC 27710

Selected Publications

Hospital Admissions and Mortality in Patients With Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.

Journal Article J Clin Rheumatol · September 1, 2023 BACKGROUND/OBJECTIVES: Anti-neutrophil cytoplasmic antibody-associated vasculitis has reported hospital mortality rates ranging between 10% and 20% with inadequate information regarding causes and outcomes of these hospitalizations. Characterization of out ... Full text Link to item Cite

Long-Term Safety of Rituximab in Granulomatosis With Polyangiitis and in Microscopic Polyangiitis.

Journal Article Arthritis Care Res (Hoboken) · September 2021 OBJECTIVE: The present study was undertaken to conduct a phase IV, open-label, prospective study to characterize the long-term safety of rituximab in a 4-year observational registry of adult patients with granulomatosis with polyangiitis (GPA) or microscop ... Full text Link to item Cite

Rituximab for the treatment of relapses in antineutrophil cytoplasmic antibody-associated vasculitis.

Journal Article Arthritis Rheumatol · November 2014 OBJECTIVE: Disease relapses are frequent in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). This study was undertaken to evaluate outcomes in patients with AAV who are re-treated with rituximab (RTX) and prednisone for severe disease relap ... Full text Link to item Cite

Clinical outcomes of remission induction therapy for severe antineutrophil cytoplasmic antibody-associated vasculitis.

Journal Article Arthritis Rheum · September 2013 OBJECTIVE: To evaluate the reasons that complete remission is not achieved or maintained with original treatment in some patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treated with rituximab (RTX) or with cyclophospham ... Full text Link to item Cite

Efficacy of remission-induction regimens for ANCA-associated vasculitis.

Journal Article N Engl J Med · August 1, 2013 BACKGROUND: The 18-month efficacy of a single course of rituximab as compared with conventional immunosuppression with cyclophosphamide followed by azathioprine in patients with severe (organ-threatening) antineutrophil cytoplasmic antibody (ANCA)-associat ... Full text Link to item Cite

Ovarian reserve diminished by oral cyclophosphamide therapy for granulomatosis with polyangiitis (Wegener's).

Journal Article Arthritis Care Res (Hoboken) · December 2011 OBJECTIVE: Standard treatment for severe granulomatosis with polyangiitis (Wegener's) (GPA) is daily oral cyclophosphamide (CYC), a cytotoxic agent associated with ovarian failure. In this study, we assessed the rate of diminished ovarian reserve in women ... Full text Link to item Cite

Solid malignancies among etanercept-treated patients with granulomatosis with polyangiitis (Wegener's): long-term followup of a multicenter longitudinal cohort.

Journal Article Arthritis Rheum · August 2011 OBJECTIVE: An association between therapeutic inhibition of tumor necrosis factor (TNF) and solid malignancies was observed during the Wegener's Granulomatosis Etanercept Trial (WGET), which included 180 patients with granulomatosis with polyangiitis (Wege ... Full text Link to item Cite

Rituximab versus cyclophosphamide for ANCA-associated vasculitis.

Journal Article N Engl J Med · July 15, 2010 Featured Publication BACKGROUND: Cyclophosphamide and glucocorticoids have been the cornerstone of remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis for 40 years. Uncontrolled studies suggest that rituximab is effective and ... Full text Link to item Cite

Alemtuzumab vs. interferon beta-1a in early multiple sclerosis.

Journal Article N Engl J Med · October 23, 2008 BACKGROUND: Alemtuzumab, a humanized monoclonal antibody that targets CD52 on lymphocytes and monocytes, may be an effective treatment for early multiple sclerosis. METHODS: In this phase 2, randomized, blinded trial involving previously untreated, early, ... Full text Link to item Cite

The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event.

Journal Article J Rheumatol · December 2007 OBJECTIVE: Venous thrombotic events (VTE), including both deep venous thrombosis and pulmonary emboli, are now recognized as an important complication of Wegener's granulomatosis (WG), but the mechanism(s) of this occurrence is unclear. The frequency of an ... Link to item Cite

Solid malignancies among patients in the Wegener's Granulomatosis Etanercept Trial.

Journal Article Arthritis Rheum · May 2006 Featured Publication OBJECTIVE: Etanercept is a soluble fusion protein designed to inhibit tumor necrosis factor (TNF). During the Wegener's Granulomatosis Etanercept Trial (WGET), a placebo-controlled trial of etanercept given in addition to standard therapy for remission ind ... Full text Link to item Cite

Herpes zoster in immunocompromised patients: incidence, timing, and risk factors.

Journal Article Am J Med · December 2005 Featured Publication PURPOSE: To evaluate the risk factors for herpes zoster as well as the incidence and timing of this complication in patients who were treated with immunosuppression because of active Wegener's granulomatosis. SUBJECTS AND METHODS: We studied the 180 Wegene ... Full text Link to item Cite

Damage caused by Wegener's granulomatosis and its treatment: prospective data from the Wegener's Granulomatosis Etanercept Trial (WGET).

Journal Article Arthritis Rheum · July 2005 OBJECTIVE: To analyze damage occurring in patients with Wegener's granulomatosis (WG) enrolled in the WG Etanercept Trial (WGET) and to correlate that damage with disease activity, adverse events, and quality of life. METHODS: The Vasculitis Damage Index ( ... Full text Link to item Cite

Brief Communication: High Incidence of Venous Thrombotic Events among Patients with Wegener Granulomatosis: The Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study.

Journal Article Ann Intern Med · April 19, 2005 Background: Venous thrombotic events (VTEs) have been observed in Wegener granulomatosis, but the incidence rate is not known. Objective: To measure the incidence of VTEs in patients with Wegener granulomatosis. Design: Prospective, observational cohort st ... Full text Link to item Cite

Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study.

Journal Article Ann Intern Med · April 19, 2005 BACKGROUND: Venous thrombotic events (VTEs) have been observed in Wegener granulomatosis, but the incidence rate is not known. OBJECTIVE: To measure the incidence of VTEs in patients with Wegener granulomatosis. DESIGN: Prospective, observational cohort st ... Full text Link to item Cite

Etanercept plus standard therapy for Wegener's granulomatosis.

Journal Article N Engl J Med · January 27, 2005 Featured Publication BACKGROUND: The majority of patients with Wegener's granulomatosis have disease flares after conventional medications are tapered. There is no consistently safe, effective treatment for the maintenance of remission. METHODS: We conducted a randomized, plac ... Full text Link to item Cite

Reply

Journal Article Arthritis & Rheumatism · January 2004 Full text Cite

Urinary type II collagen neoepitope as an outcome measure for relapsing polychondritis.

Journal Article Arthritis Rheum · October 2003 Herein we describe the case of a man who was diagnosed as having relapsing polychondritis (RP) when he was 18 years of age and was treated over the course of 2 years with numerous immunosuppressive agents, including tumor necrosis factor alpha (TNFalpha) i ... Full text Link to item Cite

Wegener's granulomatosis: survey of 701 patients in North America. Changes in outcome in the 1990s.

Journal Article J Rheumatol · February 2002 OBJECTIVE: To study the medical and socioeconomic impact of Wegener's granulomatosis (WG) in a large cohort (n = 701) of patients who are members of the international WG Support Group (WGSG). METHODS: Forty questions designed and validated by one of the au ... Link to item Cite

Relapsing polychondritis affecting the lower respiratory tract.

Journal Article AJR Am J Roentgenol · January 2002 OBJECTIVE: The purpose of this study was to describe the CT findings of lower respiratory tract involvement by relapsing polychondritis. CONCLUSION: The most common CT manifestations were increased attenuation and smooth thickening of airway walls. Trachea ... Full text Link to item Cite

A disease-specific activity index for Wegener's granulomatosis: modification of the Birmingham Vasculitis Activity Score. International Network for the Study of the Systemic Vasculitides (INSSYS).

Journal Article Arthritis Rheum · April 2001 Featured Publication OBJECTIVE: To refine and validate the Birmingham Vasculitis Activity Score (BVAS) as a disease-specific activity index for Wegener's granulomatosis (WG). METHODS: Sixteen members of the International Network for the Study of the Systemic Vasculitides (INSS ... Full text Link to item Cite

American College of Rheumatology Criteria for the Diagnosis of Vasculitis

Journal Article Annals of Internal Medicine · May 18, 1999 Full text Cite

Gouty tophus and tarsal tunnel syndrome.

Journal Article J Clin Rheumatol · February 1999 Full text Link to item Cite

Gouty tophus and tarsal tunnel syndrome [4] (multiple letters)

Journal Article Journal of Clinical Rheumatology · January 1, 1999 Cite

Limitations of the 1990 American College of Rheumatology classification criteria in the diagnosis of vasculitis.

Journal Article Ann Intern Med · September 1, 1998 BACKGROUND: The American College of Rheumatology (ACR) established criteria to discriminate among patients with seven types of vasculitis. Although designated as "classification criteria" for research, these criteria are often used for diagnosis. OBJECTIVE ... Full text Link to item Cite

Multiple myeloma-associated amyloidosis and giant cell arteritis.

Journal Article Arthritis Rheum · July 1998 Primary systemic amyloidosis has been associated with the development of symptoms and clinical features characteristic of polymyalgia rheumatica and/or giant cell arteritis (GCA). Case reports of this clinical entity have been published, stating that the a ... Full text Link to item Cite

Antiphospholipid antibodies: findings at arteriography.

Journal Article AJNR Am J Neuroradiol · April 1998 PURPOSE: The purpose of this study was to determine the frequency and types of abnormalities at arteriography in patients with antiphospholipid antibodies (APA) and ischemic cerebrovascular events. METHODS: Twenty-three patients with APA and ischemic cereb ... Link to item Cite

Systemic thrombosis in patients with antiphospholipid antibodies: lesion distribution and imaging findings.

Journal Article AJR Am J Roentgenol · February 1998 OBJECTIVE: The purpose of this study was to determine the patterns of non-CNS thromboses in patients with a hypercoagulable state associated with antiphospholipid antibodies (APA). MATERIALS AND METHODS: A search of our institution's clinical coagulation a ... Full text Link to item Cite

Diagnosis and treatment of the systemic and cutaneous necrotizing vasculitis syndromes.

Journal Article Med Clin North Am · January 1997 Advances in understanding of the spectrum of clinical presentations of patients with systemic and cutaneous necrotizing vasculitis as well as further work on pathogenesis of these conditions has helped with diagnosis of these conditions. Therapies for syst ... Full text Link to item Cite

Patients with antiphospholipid antibodies: CT and MR findings of the brain.

Journal Article AJR Am J Roentgenol · December 1996 OBJECTIVE: The purpose of this study was to determine the spectrum of neuroradiologic findings in patients with antiphospholipid antibodies (APA) and to compare findings in systemic lupus erythematosus (SLE) and non-SLE patients. MATERIALS AND METHODS: We ... Full text Link to item Cite

Gouty tophus causing tarsal tunnel syndrome.

Journal Article J Clin Rheumatol · October 1996 Tarsal tunnel syndrome (TTS), first described in 1962, has been associated with a variety of causes, including trauma, neurilemomas, rheumatoid arthritis, and hypothyroidism. We report the first case of TTS caused by a tophaceous mass in the tarsal tunnel ... Full text Link to item Cite

Testing with Antineutrophil Cytoplasmic Antibody To Diagnose Wegener Granulomatosis

Journal Article Annals of Internal Medicine · October 1, 1996 Full text Cite

Clinical, biochemical and pathological predictors of poor response to intravenous cyclophosphamide in patients with proliferative lupus nephritis.

Journal Article Clin Nephrol · September 1996 BACKGROUND: Reports in the literature on the outcome of lupus nephritis (LN) treated with intravenous (i.v.) cyclophosphamide have varied considerably. Previous studies have suggested that less than 25% of patients with LN will progress to end stage renal ... Link to item Cite

Wegener granulomatosis: CT and MR findings.

Journal Article AJNR Am J Neuroradiol · April 1996 PURPOSE: To demonstrate the spectrum of CT and MR imaging findings in patients with Wegener granulomatosis and to determine how often these findings could be attributed to either direct extension from paranasal or orbital disease sites, remote granulomas, ... Link to item Cite

Orbital involvement by Wegener's granulomatosis: imaging findings.

Journal Article AJR Am J Roentgenol · April 1996 OBJECTIVE: The purpose of this study was to define patterns of Wegener's granulomatosis (WG) orbital disease involvement. SUBJECTS AND METHODS: We evaluated the orbital examinations of 14 WG patients (CT for nine, MR imaging for three, and both CT and MR i ... Full text Link to item Cite

Retroperitoneal fibrosis. A true connective tissue disease.

Journal Article Rheum Dis Clin North Am · February 1996 Featured Publication Retroperitoneal fibrosis, a disease that can occur at any age, is characterized by a periaortic fibrous mass that often surrounds the ureters, leading to ureteral obstruction. Patients who present with this disease may complain of flank pain and acute rena ... Full text Link to item Cite

c-ANCA as a marker of Wegener's disease - Reply

Journal Article LANCET · January 13, 1996 Link to item Cite

Neuro-Behcet's disease in Japan - Reply

Journal Article NEUROLOGY · 1996 Full text Cite

Neuroradiologic findings in polyarteritis nodosa.

Journal Article AJNR Am J Neuroradiol · 1996 PURPOSE: To demonstrate the neuroradiologic findings in patients with polyarteritis nodosa. METHODS: A review of hospital records for a 10-year period revealed 50 patients with a discharge diagnosis of polyarteritis nodosa. Thirteen patients had undergone ... Link to item Cite

Rocky Mountain spotted fever presenting with acute monarticular arthritis.

Journal Article Arthritis Rheum · January 1996 This report describes a 30-year-old man who presented with an acute multisystem illness which was diagnosed as Rocky Mountain spotted fever (RMSF). Near the time of admission the patient was noted to have a newly developed aseptic monarticular arthritis of ... Full text Link to item Cite

Myotropic Th1 T helper cell lymphoma presenting as granulomatous inflammatory masses in synovium and muscle

Journal Article Journal of Investigative Medicine · January 1, 1996 Human T helper (Th) lymphocyte subsets can be differentiated by cytokine production; Thl cells produce inteferon-gamma and interleukin-2, while Th2 cells produce interleukin-4 and interleukin-5. Imbalance of Th subsets leads to disordered immunity and a my ... Cite

The role of antineutrophil cytoplasmic antibody (c-ANCA) testing in the diagnosis of Wegener granulomatosis. A literature review and meta-analysis.

Journal Article Ann Intern Med · December 15, 1995 Featured Publication PURPOSE: To summarize the literature on the clinical utility of antineutrophil cytoplasmic antibody (c-ANCA) as a diagnostic marker for Wegener granulomatosis. DATA SOURCES: A structured literature search was done using MEDLINE; this search, combined with ... Full text Link to item Cite

A prospective study of antineutrophil cytoplasmic antibody (c-ANCA) and clinical criteria in diagnosing Wegener's granulomatosis.

Journal Article Lancet · October 7, 1995 Antineutrophil cytoplasmic antibody (c-ANCA) has a reported sensitivity and specificity greater than 90% for active Wegener's granulomatosis in selected patients with previously-defined disease. Because of these reports, some clinicians believe that a posi ... Full text Link to item Cite

Neuro-Behçet's disease: factors hampering proper diagnosis.

Journal Article Neurology · September 1995 We reviewed the clinical course of nine patients with neuro-Behçet's disease to assess difficulties in making this diagnosis. Factors delaying proper diagnosis included lack of accurate history and physical examination, lack of recognition of an underlying ... Full text Link to item Cite

Fetal renal vein thrombosis, hydrops fetalis, and maternal lupus anticoagulant. A case report.

Journal Article Prenat Diagn · September 1994 Hydrops fetalis with fetal renal vein thrombosis in a mother with antiphospholipid antibody syndrome detected post-partum suggests an underlying pathogenetic association that may provide new strategies for treatment of a lethal disorder. ... Full text Link to item Cite

Treatment of Mycobacterium haemophilum infection with an antibiotic regimen including clarithromycin.

Journal Article Br J Dermatol · September 1994 A patient with rheumatoid arthritis developed ulcerated nodules predominantly on his legs. Skin biopsy and culture demonstrated rheumatoid vasculitis and infection with Mycobacterium haemophilum. Improvement was not seen until clarithromycin was added to h ... Full text Link to item Cite

Cooccurrence of collagenous colitis with seronegative spondyloarthropathy: report of a case and literature review.

Journal Article J Rheumatol · December 1993 Collagenous colitis is an uncommon cause of chronic watery diarrhea, characterized by colonic deposition of collagen. Nonerosive, oligoarticular, peripheral arthritis has previously been noted in about 7% of patients with collagenous colitis. We describe a ... Link to item Cite

Hyperrenin-hyperaldosterone-dependent malignant hypertension in polyarteritis nodosa.

Journal Article South Med J · December 1993 We have described a patient, subsequently found to have polyarteritis, whose renin activity was 60 times normal, a level associated with malignant hypertension and severe renal artery stenosis. The severe hypertension and its resistance to multiple medicat ... Full text Link to item Cite

TREATMENT OF EROSIVE OSTEOARTHRITIS WITH HYDROXYCHLOROQUINE

Journal Article ARTHRITIS AND RHEUMATISM · September 1, 1993 Link to item Cite

Primary systemic amyloidosis masquerading as giant cell arteritis. Case report and review of the literature.

Journal Article Arthritis Rheum · March 1993 Amyloidosis is a rare disease in which a fibrillar protein is deposited in multiple human tissues. Of the 4 subtypes, the most common type involving rheumatic disease features is hemodialysis-associated amyloidosis. Herein we describe an elderly man who pr ... Full text Link to item Cite

Miscellaneous vasculitic syndromes including Behçet's disease and central nervous system vasculitis.

Journal Article Curr Opin Rheumatol · January 1993 Behçet's disease is a chronic, relapsing, inflammatory process with clinical features of aphthous oral and genital ulcerations, uveitis, cutaneous vasculitis, arthritis, and central nervous system involvement. Large-vessel vasculitis, thrombophlebitis, and ... Full text Link to item Cite

Cyclosporin A therapy for Wegener's granulomatosis.

Journal Article Adv Exp Med Biol · 1993 Five patients with active Wegener's granulomatosis were treated with the immunosuppressive agent Cyclosporin A, along with low dose prednisone. All five patients had previously taken cyclophosphamide, but further treatment with this agent was not desired, ... Full text Link to item Cite

Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review.

Journal Article J Rheumatol · September 1992 We describe 2 Caucasian men with rheumatoid arthritis (RA) who developed non-Hodgkin's lymphoma of identical histological type during treatment with low dose oral weekly methotrexate (MTX). Both patients had longstanding RA and had been treated with MTX fo ... Link to item Cite

COGAN SYNDROME - CLINICAL-FEATURES AND OUTCOMES

Journal Article ARTHRITIS AND RHEUMATISM · September 1, 1992 Link to item Cite

ANCA--the rheumatologist's perspective 1992.

Journal Article Bull Rheum Dis · 1992 Link to item Cite

Large vessel vasculitis of the central nervous system in systemic lupus erythematosus: report and review of the literature.

Journal Article J Rheumatol · May 1991 Large vessel vasculitis rarely involves the central nervous system in patients with systemic lupus erythematosus. We describe an exemplary case, along with its dramatic cerebral angiogram, and review the literature on this unusual entity. ... Link to item Cite

Discrimination of antineutrophil antibodies from antinuclear antibodies using immunofluorescence on neutrophils and HL60 cells.

Journal Article J Rheumatol · April 1991 Sera of 209 patients with rheumatic disease demonstrated 3 patterns of immunofluorescence (IF) on ethanol fixed neutrophils (PMN) and a promyelocytic cell line (HL60): (1) cytoplasmic on PMN, negative on HL60 cells, (2) nuclear or perinuclear on PMN, negat ... Link to item Cite

Trazodone-related exercise-induced nonsustained ventricular tachycardia.

Journal Article Chest · July 1990 A 79-year-old woman in the course of a syncope evaluation is shown to have a trazodone-related cardiac arrhythmia confirmed by drug rechallenge. This nontricyclic antidepressant should be considered as potentially arrhythmogenic despite its generally favor ... Full text Link to item Cite

Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.

Journal Article Clin Immunol Immunopathol · February 1990 To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in ... Full text Link to item Cite

Methotrexate-associated hepatotoxicity: retrospective analysis of 210 patients with rheumatoid arthritis.

Journal Article Am J Med · December 1988 PURPOSE: Beginning in the 1980s, methotrexate has been used successfully to treat rheumatoid arthritis. The magnitude and severity of short- and long-term methotrexate toxicity, however, have not been adequately investigated. Our study was performed to det ... Full text Link to item Cite

Ureaplasma urealyticum septic arthritis in hypogammaglobulinemia.

Journal Article J Rheumatol · February 1988 We describe a hypogammaglobulinemic man with erosive oligoarticular septic arthritis due to Ureaplasma urealyticum. His clinical course was complicated by a subcutaneous abscess. Multiple synovial cultures were negative until finally cultures specific for ... Link to item Cite

Reply

Journal Article Arthritis & Rheumatism · January 1, 1988 Full text Cite

Survival in systemic lupus erythematosus. A multivariate analysis of demographic factors.

Journal Article Arthritis Rheum · December 1987 We analyzed survival rate and important clinical outcomes in 411 patients with systemic lupus erythematosus who were seen at our center between 1969 and 1984. All eligible subjects met 4 of the revised American Rheumatism Association criteria for systemic ... Full text Link to item Cite

Pyomyositis and polyarticular septic arthritis from Hemophilus influenzae in a nonimmunocompromised adult.

Journal Article J Rheumatol · December 1987 We describe a healthy woman in whom pyomyositis of the left buttock, polyarticular septic arthritis, and meningitis due to Hemophilus influenzae type B developed after pneumonia. Systemic antibiotic therapy and local drainage provided a good result. This i ... Link to item Cite

Wegener's granulomatosis involving the breast. Report of three cases and review of the literature.

Journal Article Am J Med · July 1987 Three cases of necrotizing granulomatous vasculitis of the Wegener's type involving the breast are described. In each, the presumed diagnosis was localized or metastatic carcinoma. The breast lesion and other manifestations of Wegener's granulomatosis deve ... Full text Link to item Cite

Defective release of tissue plasminogen activator in systemic and cutaneous vasculitis.

Journal Article Am J Med · March 1987 The fibrinolytic system in a group of 23 patients with vasculitis and 10 patients with the cutaneous vasculitis atrophie blanche were studied. These patients were found to have markedly suppressed release of vascular tissue plasminogen activator (t-PA) sto ... Full text Link to item Cite

Giant cell arteritis and polymyalgia rheumatica. Review for the otolaryngologist.

Journal Article Ann Otol Rhinol Laryngol · 1987 Patients suspected of giant cell arteritis or polymyalgia rheumatica are often referred to the otolaryngologist for temporal artery biopsy. These patients may initially present to the otolaryngologist with symptoms referable to the head and neck. A compreh ... Full text Link to item Cite

Multiple unusual manifestations of Wegener's granulomatosis: breast mass, microangiopathic hemolytic anemia, consumptive coagulopathy, and low erythrocyte sedimentation rate.

Journal Article Arthritis Rheum · December 1986 We describe a patient who presented with multiple unusual manifestations of Wegener's granulomatosis, including a breast mass, microangiopathic hemolytic anemia, and consumptive coagulopathy. Erythrocyte sedimentation rate (Westergren), usually elevated in ... Full text Link to item Cite

Acute gout presenting in the manubriosternal joint.

Journal Article Arthritis Rheum · April 1986 A 54-year-old black man developed acute pain and swelling of the manubriosternal joint. Acute gouty arthritis was diagnosed by arthrocentesis and polarizing microscopy. The histology of the manubriosternal joint and its involvement in other arthritides are ... Full text Link to item Cite

Polymyalgia rheumatica and temporal arteritis.

Journal Article Med Clin North Am · March 1986 Polymyalgia rheumatica and temporal arteritis are a clinical syndrome and clinicopathologic entity, respectively. Polymyalgia rheumatica occurs more commonly than temporal arteritis, with approximately half of all patients with temporal arteritis having th ... Full text Link to item Cite

Isolated atlantoaxial subluxation as the presenting manifestation of inflammatory bowel disease.

Journal Article Am J Med · March 1986 A previously healthy 21-year-old black woman is described in whom erosive cervical spine disease with C1-C2 subluxation spontaneously developed. Various investigations led to the discovery of Crohn's disease, a heretofore unreported association. Thus, clin ... Full text Link to item Cite

Diagnostic and therapeutic approach to the patient with vasculitis.

Journal Article Med Clin North Am · March 1986 This article presents an approach to the diagnosis and therapy of patients with vasculitis. Effective treatment of patients with vasculitis requires a systemic approach to diagnosis and classification of disease, evaluation of the extent of organ system in ... Full text Link to item Cite

"Tips" on acute arthritis and clubbing.

Journal Article N C Med J · October 1984 Link to item Cite

LATE ONSET SYSTEMIC LUPUS-ERYTHEMATOSUS CHANGING CONCEPTS

Journal Article CLINICAL RESEARCH · January 1, 1984 Link to item Cite

LATE ONSET SYSTEMIC LUPUS-ERYTHEMATOSUS - RACE AND SEX FACTORS

Journal Article CLINICAL RESEARCH · January 1, 1984 Link to item Cite

Occult fractures of the knee: tomographic evaluation.

Journal Article Radiology · August 1983 Seven adults with painful effusions of the knee were examined for occult fractures using pluridirectional tomography in the coronal and lateral planes. Six patients (ages 50-82 years) were osteopenic and gave histories ranging from none to mild trauma; one ... Full text Link to item Cite