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Nrupen Bhavsar

Associate Professor in Surgery
Surgery, Surgical Sciences
710 W. Main St, Durham, NC 27701
710 W. Main St, Durham, NC 27710

Selected Publications


Development of an interactive dashboard for gun violence pattern analysis and intervention design at the local level.

Journal Article JAMIA Open · December 2023 INTRODUCTION: Gun violence remains a concerning and persistent issue in our country. Novel dashboards may integrate and summarize important clinical and non-clinical data that can inform targeted interventions to address the underlying causes of gun violen ... Full text Link to item Cite

Residential Structural Racism and Prevalence of Chronic Health Conditions.

Journal Article JAMA Netw Open · December 1, 2023 IMPORTANCE: Studies elucidating determinants of residential neighborhood-level health inequities are needed. OBJECTIVE: To quantify associations of structural racism indicators with neighborhood prevalence of chronic kidney disease (CKD), diabetes, and hyp ... Full text Link to item Cite

BOLD: Blood-gas and Oximetry Linked Dataset - Open Source Research.

Journal Article medRxiv · October 3, 2023 Pulse oximeters measure peripheral arterial oxygen saturation (SpO 2 ) noninvasively, while the gold standard (SaO 2 ) involves arterial blood gas measurement. There are known racial and ethnic disparities in their performance. BOLD is a new comprehensive ... Full text Link to item Cite

Do You PROMIS (Patient Reported Outcomes Measurement Information System)? Physical Function and Pain Interference Scores After Total Knee and Hip Arthroplasty.

Journal Article Arthroplast Today · October 2023 BACKGROUND: Physical function and pain outcomes vary after arthroplasty. We investigated differences in postoperative Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) and pain interference (PI) scores for patients un ... Full text Link to item Cite

A comparison of deprivation indices and application to transplant populations.

Journal Article Am J Transplant · March 2023 The choice of deprivation index can influence conclusions drawn regarding the extent of deprivation within a community and the identification of the most deprived communities in the United States. This study aimed to determine the degree of correlation amo ... Full text Link to item Cite

Association of Perceived Neighborhood Health With Hypertension Self-care.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Hypertension self-management is recommended for optimal blood pressure (BP) control, but self-identified residential contextual factors that hinder hypertension self-care are understudied. OBJECTIVE: To quantify perceived neighborhood health an ... Full text Link to item Cite

Association between Gentrification and Health and Healthcare Utilization.

Journal Article J Urban Health · December 2022 There is tremendous interest in understanding how neighborhoods impact health by linking extant social and environmental drivers of health (SDOH) data with electronic health record (EHR) data. Studies quantifying such associations often use static neighbor ... Full text Link to item Cite

Assessment of Population-Level Disadvantage Indices to Inform Equitable Health Policy.

Journal Article Milbank Q · December 2022 UNLABELLED: Policy Points The rapid uptake of disadvantage indices during the pandemic highlights investment in implementing tools that address health equity to inform policy. Existing indices differ in their design, including data elements, social determi ... Full text Link to item Cite

Social Determinants of Health Data Capture Within National and Health System Data Sources

Conference Journal of the American College of Surgeons · November 2022 Full text Cite

Social determinants of health data in solid organ transplantation: National data sources and future directions.

Journal Article Am J Transplant · October 2022 Health equity research in transplantation has largely relied on national data sources, yet the availability of social determinants of health (SDOH) data varies widely among these sources. We sought to characterize the extent to which national data sources ... Full text Link to item Cite

Geospatial Analysis of Organ Transplant Referral Regions.

Journal Article JAMA Netw Open · September 1, 2022 IMPORTANCE: System and center-level interventions to improve health equity in organ transplantation benefit from robust characterization of the referral population served by each transplant center. Transplant referral regions (TRRs) define geographic catch ... Full text Link to item Cite

Chronic Pain Prevalence and Factors Associated With High Impact Chronic Pain following Total Joint Arthroplasty: An Observational Study.

Journal Article J Pain · March 2022 Hip, knee, and shoulder arthroplasty are among the most frequently performed orthopaedic procedures in the United States. High impact and bothersome chronic pain rates following total joint arthroplasty (TJA) are unknown; as are factors that predict these ... Full text Link to item Cite

A Prospective Multicenter Evaluation of Initial Treatment Choice in Metastatic Renal Cell Carcinoma Prior to the Immunotherapy Era: The MaRCC Registry Experience.

Journal Article Clin Genitourin Cancer · February 2022 INTRODUCTION: The Metastatic Renal Cell Carcinoma (MaRCC) Registry provides prospective data on real-world treatment patterns and outcomes in patients with metastatic renal cell carcinoma (mRCC). METHODS AND MATERIALS: Patients with mRCC and no prior syste ... Full text Link to item Cite

Psychosocial determinants of cardiovascular events among black Americans with chronic kidney disease or associated risk factors in the Jackson heart study.

Journal Article BMC Nephrol · November 11, 2021 BACKGROUND: Individuals with chronic kidney disease (CKD), hypertension (HTN), or diabetes mellitus (DM) are at increased risk for cardiovascular disease (CVD). The extent to which psychosocial factors are associated with increased CVD risk within these in ... Full text Link to item Cite

A prospective study of multiple sleep dimensions and hypertension risk among white, black and Hispanic/Latina women: findings from the Sister Study.

Journal Article J Hypertens · November 1, 2021 BACKGROUND: Poor sleep is associated with increased hypertension risk, but few studies have evaluated multiple sleep dimensions or investigated racial/ethnic disparities in this association among women. METHOD: We investigated multiple sleep dimensions (sl ... Full text Link to item Cite

Predicting Recurrent Care Seeking of Physical Therapy for Musculoskeletal Pain Conditions.

Journal Article Pain Med · August 6, 2021 OBJECTIVE: Musculoskeletal pain conditions are a leading cause of pain and disability internationally and a common reason to seek health care. Accurate prediction of recurrence of health care seeking due to musculoskeletal conditions could allow for better ... Full text Link to item Cite

Active surveillance of metastatic renal cell carcinoma: Results from a prospective observational study (MaRCC).

Journal Article Cancer · July 1, 2021 BACKGROUND: Systemic therapy (ST) can be deferred in patients who have metastatic renal cell carcinoma (mRCC) and slow-growing metastases. Currently, this subset of patients managed with active surveillance (AS) is not well described in the literature. MET ... Full text Open Access Link to item Cite

Abstract P112: Impact Of Look Back Period Length On Associations When Using Electronic Health Record Data For Epidemiologic Research

Conference Circulation · May 25, 2021 Introduction: Studies using electronic health record (EHR) data often have a limited number of years available for analysis. There is a trade off between the look back period length used to define bas ... Full text Cite

Development of an interactive dashboard for gun violence pattern analysis and intervention design at the local level.

Journal Article JAMIA Open · December 2023 INTRODUCTION: Gun violence remains a concerning and persistent issue in our country. Novel dashboards may integrate and summarize important clinical and non-clinical data that can inform targeted interventions to address the underlying causes of gun violen ... Full text Link to item Cite

Residential Structural Racism and Prevalence of Chronic Health Conditions.

Journal Article JAMA Netw Open · December 1, 2023 IMPORTANCE: Studies elucidating determinants of residential neighborhood-level health inequities are needed. OBJECTIVE: To quantify associations of structural racism indicators with neighborhood prevalence of chronic kidney disease (CKD), diabetes, and hyp ... Full text Link to item Cite

BOLD: Blood-gas and Oximetry Linked Dataset - Open Source Research.

Journal Article medRxiv · October 3, 2023 Pulse oximeters measure peripheral arterial oxygen saturation (SpO 2 ) noninvasively, while the gold standard (SaO 2 ) involves arterial blood gas measurement. There are known racial and ethnic disparities in their performance. BOLD is a new comprehensive ... Full text Link to item Cite

Do You PROMIS (Patient Reported Outcomes Measurement Information System)? Physical Function and Pain Interference Scores After Total Knee and Hip Arthroplasty.

Journal Article Arthroplast Today · October 2023 BACKGROUND: Physical function and pain outcomes vary after arthroplasty. We investigated differences in postoperative Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) and pain interference (PI) scores for patients un ... Full text Link to item Cite

A comparison of deprivation indices and application to transplant populations.

Journal Article Am J Transplant · March 2023 The choice of deprivation index can influence conclusions drawn regarding the extent of deprivation within a community and the identification of the most deprived communities in the United States. This study aimed to determine the degree of correlation amo ... Full text Link to item Cite

Association of Perceived Neighborhood Health With Hypertension Self-care.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Hypertension self-management is recommended for optimal blood pressure (BP) control, but self-identified residential contextual factors that hinder hypertension self-care are understudied. OBJECTIVE: To quantify perceived neighborhood health an ... Full text Link to item Cite

Association between Gentrification and Health and Healthcare Utilization.

Journal Article J Urban Health · December 2022 There is tremendous interest in understanding how neighborhoods impact health by linking extant social and environmental drivers of health (SDOH) data with electronic health record (EHR) data. Studies quantifying such associations often use static neighbor ... Full text Link to item Cite

Assessment of Population-Level Disadvantage Indices to Inform Equitable Health Policy.

Journal Article Milbank Q · December 2022 UNLABELLED: Policy Points The rapid uptake of disadvantage indices during the pandemic highlights investment in implementing tools that address health equity to inform policy. Existing indices differ in their design, including data elements, social determi ... Full text Link to item Cite

Social Determinants of Health Data Capture Within National and Health System Data Sources

Conference Journal of the American College of Surgeons · November 2022 Full text Cite

Social determinants of health data in solid organ transplantation: National data sources and future directions.

Journal Article Am J Transplant · October 2022 Health equity research in transplantation has largely relied on national data sources, yet the availability of social determinants of health (SDOH) data varies widely among these sources. We sought to characterize the extent to which national data sources ... Full text Link to item Cite

Geospatial Analysis of Organ Transplant Referral Regions.

Journal Article JAMA Netw Open · September 1, 2022 IMPORTANCE: System and center-level interventions to improve health equity in organ transplantation benefit from robust characterization of the referral population served by each transplant center. Transplant referral regions (TRRs) define geographic catch ... Full text Link to item Cite

Chronic Pain Prevalence and Factors Associated With High Impact Chronic Pain following Total Joint Arthroplasty: An Observational Study.

Journal Article J Pain · March 2022 Hip, knee, and shoulder arthroplasty are among the most frequently performed orthopaedic procedures in the United States. High impact and bothersome chronic pain rates following total joint arthroplasty (TJA) are unknown; as are factors that predict these ... Full text Link to item Cite

A Prospective Multicenter Evaluation of Initial Treatment Choice in Metastatic Renal Cell Carcinoma Prior to the Immunotherapy Era: The MaRCC Registry Experience.

Journal Article Clin Genitourin Cancer · February 2022 INTRODUCTION: The Metastatic Renal Cell Carcinoma (MaRCC) Registry provides prospective data on real-world treatment patterns and outcomes in patients with metastatic renal cell carcinoma (mRCC). METHODS AND MATERIALS: Patients with mRCC and no prior syste ... Full text Link to item Cite

Psychosocial determinants of cardiovascular events among black Americans with chronic kidney disease or associated risk factors in the Jackson heart study.

Journal Article BMC Nephrol · November 11, 2021 BACKGROUND: Individuals with chronic kidney disease (CKD), hypertension (HTN), or diabetes mellitus (DM) are at increased risk for cardiovascular disease (CVD). The extent to which psychosocial factors are associated with increased CVD risk within these in ... Full text Link to item Cite

A prospective study of multiple sleep dimensions and hypertension risk among white, black and Hispanic/Latina women: findings from the Sister Study.

Journal Article J Hypertens · November 1, 2021 BACKGROUND: Poor sleep is associated with increased hypertension risk, but few studies have evaluated multiple sleep dimensions or investigated racial/ethnic disparities in this association among women. METHOD: We investigated multiple sleep dimensions (sl ... Full text Link to item Cite

Predicting Recurrent Care Seeking of Physical Therapy for Musculoskeletal Pain Conditions.

Journal Article Pain Med · August 6, 2021 OBJECTIVE: Musculoskeletal pain conditions are a leading cause of pain and disability internationally and a common reason to seek health care. Accurate prediction of recurrence of health care seeking due to musculoskeletal conditions could allow for better ... Full text Link to item Cite

Active surveillance of metastatic renal cell carcinoma: Results from a prospective observational study (MaRCC).

Journal Article Cancer · July 1, 2021 BACKGROUND: Systemic therapy (ST) can be deferred in patients who have metastatic renal cell carcinoma (mRCC) and slow-growing metastases. Currently, this subset of patients managed with active surveillance (AS) is not well described in the literature. MET ... Full text Open Access Link to item Cite

Abstract P112: Impact Of Look Back Period Length On Associations When Using Electronic Health Record Data For Epidemiologic Research

Conference Circulation · May 25, 2021 Introduction: Studies using electronic health record (EHR) data often have a limited number of years available for analysis. There is a trade off between the look back period length used to define bas ... Full text Cite

Prevalence and predictors of no-shows to physical therapy for musculoskeletal conditions.

Journal Article PLoS One · 2021 OBJECTIVES: Chronic pain affects 50 million Americans and is often treated with non-pharmacologic approaches like physical therapy. Developing a no-show prediction model for individuals seeking physical therapy care for musculoskeletal conditions has sever ... Full text Open Access Link to item Cite

Integrated Digital Health System Tools to Support Decision Making and Treatment Preparation in CKD: The PREPARE NOW Study.

Journal Article Kidney Med · 2021 RATIONALE & OBJECTIVE: Digital health system tools to support shared decision making and preparation for kidney replacement treatments for patients with chronic kidney disease (CKD) are needed. STUDY DESIGN: Descriptive study of the implementation of digit ... Full text Link to item Cite

Continuous Engagement in a Weight-Loss Program Promotes Sustained Significant Weight Loss.

Journal Article WMJ · December 2020 BACKGROUND: Significant weight loss improves health but regain is common. OBJECTIVE: The objective of the study was to determine if 2,346 members of Take Off Pounds Sensibly-a national, low-cost, peer-led weight-loss program-achieved and maintained signifi ... Link to item Cite

Democratizing health system data to impact social and environmental health contexts: a novel collaborative community data-sharing model.

Journal Article J Public Health (Oxf) · November 23, 2020 BACKGROUND: Community health data are infrequently viewed in the context of social and environmental health determinants. We developed a novel data-sharing model to democratize health system data and to facilitate community and population health improvemen ... Full text Link to item Cite

Unanticipated Respiratory Compromise and Unplanned Intubations on General Medical and Surgical Floors.

Journal Article Respir Care · September 2020 BACKGROUND: Unanticipated respiratory compromise that lead to unplanned intubations is a known phenomenon in hospitalized patients. Most events occur in patients at high risk in well-monitored units; less is known about the incidence, risk factors, and tra ... Full text Link to item Cite

Life Course Socioeconomic Status, Allostatic Load, and Kidney Health in Black Americans.

Journal Article Clin J Am Soc Nephrol · March 6, 2020 BACKGROUND AND OBJECTIVES: Low socioeconomic status confers unfavorable health, but the degree and mechanisms by which life course socioeconomic status affects kidney health is unclear. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We examined the associa ... Full text Link to item Cite

Use of Hospital Referral Regions in Evaluating End-of-Life Care.

Journal Article J Palliat Med · January 2020 Background: Hospital referral regions (HRRs) are often used to characterize inpatient referral patterns, but it is unknown how well these geographic regions are aligned with variation in Medicare-financed hospice care, which is largely provided at home. Ob ... Full text Link to item Cite

Defining gentrification for epidemiologic research: A systematic review.

Journal Article PLoS One · 2020 Neighborhoods have a profound impact on individual health. There is growing interest in the role of dynamic changes to neighborhoods-including gentrification-on the health of residents. However, research on the association between gentrification and health ... Full text Link to item Cite

Framework for improving outcome prediction for acute to chronic low back pain transitions.

Journal Article Pain Rep · 2020 Clinical practice guidelines and the Federal Pain Research Strategy (United States) have recently highlighted research priorities to lessen the public health impact of low back pain (LBP). It may be necessary to improve existing predictive approaches to me ... Full text Open Access Link to item Cite

DASH Diet and Blood Pressure Among Black Americans With and Without CKD: The Jackson Heart Study.

Journal Article Am J Hypertens · September 24, 2019 BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP) more effectively in blacks compared to other US racial subgroups. Considering chronic kidney disease (CKD) raises BP through complex mechanisms, DASH may affect ... Full text Link to item Cite

Association of functional and structural social support with chronic kidney disease among African Americans: the Jackson Heart Study.

Journal Article BMC Nephrol · July 15, 2019 BACKGROUND: There is limited evidence on the relationship between social support and renal outcomes in African Americans. We sought to determine the association of social support with prevalent chronic kidney disease (CKD) and kidney function decline in an ... Full text Link to item Cite

Modifiers of Plasma 25-Hydroxyvitamin D and Chronic Kidney Disease Outcomes in Black Americans: The Jackson Heart Study.

Internet Publication · June 1, 2019 BACKGROUND: 25-hydroxyvitamin D [25(OH)D] is lower in black compared with white Americans but is not consistently associated with outcomes in this group, possibly due to genetic and other biological differences. We examined the association of plasma 25(OH) ... Full text Open Access Link to item Cite

Patients' and Nephrologists' Evaluation of Patient-Facing Smartphone Apps for CKD.

Journal Article Clin J Am Soc Nephrol · April 5, 2019 BACKGROUND AND OBJECTIVES: Many aspects of CKD management rely heavily on patient self-care, including medication and dietary adherence, self-monitoring of BP, and daily physical activity. Growing evidence suggests that incorporating smartphone-based appli ... Full text Link to item Cite

Death of outrage over talking about dying.

Journal Article BMJ Support Palliat Care · March 2019 OBJECTIVES: We examined public reaction to the proposed Center for Medicare and Medicaid Services rule reimbursing physicians for advanced care planning (ACP) discussions with patients. METHODS: Public comments made on regulations.gov were reviewed for rel ... Full text Link to item Cite

Evaluation of Allostatic Load as a Mediator of Sleep and Kidney Outcomes in Black Americans.

Journal Article Kidney Int Rep · March 2019 INTRODUCTION: Poor sleep associates with adverse chronic kidney disease (CKD) outcomes yet the biological mechanisms underlying this relation remain unclear. One proposed mechanism is via allostatic load, a cumulative biologic measure of stress. METHODS: U ... Full text Open Access Link to item Cite

Low use of routine medical care among African Americans with high CKD risk: the Jackson Heart Study.

Journal Article BMC Nephrol · January 10, 2019 BACKGROUND: Use of routine medical care (RMC) is advocated to address ethnic/racial disparities in chronic kidney disease (CKD) risks, but use is less frequent among African Americans. Factors associated with low RMC use among African Americans at risk of ... Full text Open Access Link to item Cite

Dietary Phosphorus and Ambulatory Blood Pressure in African Americans: The Jackson Heart Study.

Journal Article Am J Hypertens · January 1, 2019 BACKGROUND: Higher dietary phosphorus is associated with left ventricular hypertrophy and mortality, which are blood pressure (BP)-related outcomes. For this reason, we hypothesized that dietary phosphorus may be associated with adverse clinic and ambulato ... Full text Link to item Cite

Longer-term Lipid-lowering Drug Use and Risk of Incident and Fatal Prostate Cancer in Black and White Men in the ARIC Study.

Journal Article Cancer Prev Res (Phila) · December 2018 Lipid-lowering medications, particularly statins, may protect against aggressive prostate cancer. Fatal prostate cancer, the most clinically relevant outcome, remains understudied for this association. We prospectively studied lipid-lowering medication use ... Full text Link to item Cite

Putting patients at the center of kidney care transitions: PREPARE NOW, a cluster randomized controlled trial.

Journal Article Contemp Clin Trials · October 2018 UNLABELLED: Care for patients transitioning from chronic kidney disease to kidney failure often falls short of meeting patients' needs. The PREPARE NOW study is a cluster randomized controlled trial studying the effectiveness of a pragmatic health system i ... Full text Link to item Cite

Value of Neighborhood Socioeconomic Status in Predicting Risk of Outcomes in Studies That Use Electronic Health Record Data.

Journal Article JAMA Netw Open · September 7, 2018 IMPORTANCE: Data from electronic health records (EHRs) are increasingly used for risk prediction. However, EHRs do not reliably collect sociodemographic and neighborhood information, which has been shown to be associated with health. The added contribution ... Full text Link to item Cite

Predicting Length of Hospice Stay: An Application of Quantile Regression.

Journal Article J Palliat Med · August 2018 BACKGROUND: Use of the Medicare hospice benefit has been associated with high-quality care at the end of life, and hospice length of use in particular has been used as a proxy for appropriate timing of hospice enrollment. Quantile regression has been under ... Full text Link to item Cite

Software for Administering the National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events: Usability Study.

Journal Article JMIR Hum Factors · July 16, 2018 BACKGROUND: The US National Cancer Institute (NCI) developed software to gather symptomatic adverse events directly from patients participating in clinical trials. The software administers surveys to patients using items from the Patient-Reported Outcomes ... Full text Link to item Cite

Obesity and synergistic risk factors for chronic kidney disease in African American adults: the Jackson Heart Study.

Journal Article Nephrol Dial Transplant · June 1, 2018 BACKGROUND: African Americans are at high risk for chronic kidney disease (CKD). Obesity may increase the risk for CKD by exacerbating features of the metabolic syndrome and promoting glomerular hyperfiltration. Whether other factors also affecting these p ... Full text Link to item Cite

Cost implications of PSA screening differ by age.

Journal Article BMC Urol · May 9, 2018 BACKGROUND: Multiple guidelines seek to alter rates of prostate-specific antigen (PSA)-based prostate cancer screening. The costs borne by payers associated with PSA-based screening for men of different age groups-including the costs of screening and subse ... Full text Link to item Cite

Will Changes to Medicare Payment Rates Alter Hospice's Cost-Saving Ability?

Journal Article J Palliat Med · May 2018 BACKGROUND: On January 1, 2016, Medicare implemented a new "two-tiered" model for hospice services, with per diem rates increased for days 1 through 60, decreased for days 61 and greater, and service intensity add-on payments made retrospectively for the l ... Full text Link to item Cite

Nondepressive Psychosocial Factors and CKD Outcomes in Black Americans.

Journal Article Clin J Am Soc Nephrol · February 7, 2018 BACKGROUND AND OBJECTIVES: Established risk factors for CKD do not fully account for risk of CKD in black Americans. We studied the association of nondepressive psychosocial factors with risk of CKD in the Jackson Heart Study. DESIGN, SETTING, PARTICIPANTS ... Full text Link to item Cite

Hospital-Based Palliative Care with Medicare Claims: Evidence From Colorado.

Journal Article Am J Hosp Palliat Care · January 2018 BACKGROUND: The prevalence of hospital-based palliative care has been largely anecdotal as an increasing service being provided and there is a need to understand what trends can be analyzed with Medicare data. OBJECTIVE: To compare 2 methods of identifying ... Full text Link to item Cite

Illustrating Informed Presence Bias in Electronic Health Records Data: How Patient Interactions with a Health System Can Impact Inference.

Journal Article EGEMS (Wash DC) · December 6, 2017 Electronic health record (EHR) data are becoming a primary resource for clinical research. Compared to traditional research data, such as those from clinical trials and epidemiologic cohorts, EHR data have a number of appealing characteristics. However, be ... Full text Link to item Cite

Delivery of Community-Based Palliative Care: Findings from a Time and Motion Study.

Journal Article J Palliat Med · October 2017 BACKGROUND: Use of palliative care has increased substantially as the population ages and as evidence for its benefits grows. However, there is limited information regarding which care activities are necessary for delivering high-quality, interdisciplinary ... Full text Link to item Cite

Case Studies from the Clinic: Initiating and Implementing Patient-Reported Outcome Measures.

Journal Article EGEMS (Wash DC) · June 12, 2017 INTRODUCTION: Self-reporting by patients though the use of electronic patient-reported outcome (PRO) measures has been shown to use increase patient satisfaction with care, and improve patient-provider communication, symptom management, and health quality. ... Full text Link to item Cite

Design and Rationale of the Metastatic Renal Cell Carcinoma (MaRCC) Registry: A Prospective Academic and Community-Based Study of Patients With Metastatic Renal Cell Cancer.

Journal Article Cancer Invest · May 28, 2017 The Metastatic Renal Cell Cancer Registry, a large, nationally representative, prospective registry of patients with metastatic renal cell carcinoma (mRCC), aims to understand real-world treatment patterns and outcomes of patients with mRCC in routine clin ... Full text Link to item Cite

Controlling for Informed Presence Bias Due to the Number of Health Encounters in an Electronic Health Record.

Journal Article Am J Epidemiol · December 1, 2016 Electronic health records (EHRs) are an increasingly utilized resource for clinical research. While their size allows for many analytical opportunities, as with most observational data there is also the potential for bias. One of the key sources of bias in ... Full text Link to item Cite

Safety and Efficacy of Radiation Therapy in Advanced Melanoma Patients Treated With Ipilimumab.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2016 PURPOSE: Ipilimumab and radiation therapy (RT) are standard treatments for advanced melanoma; preclinical models suggest the potential for synergy. However, limited clinical information exists regarding safety and optimal timing of the combination. METHODS ... Full text Link to item Cite

Abstract P4-14-16: T-cell clonality increases after neoadjuvant treatment with trastuzumab and pertuzumab

Conference Cancer Research · February 15, 2016 AbstractBackground: Baseline TIL density and T-cell clonality predict pathological complete response (pCR) to neoadjuvant (NA) trastuzumab (TRAS). Preclinical data suggests that a major mechanism of TRAS is ... Full text Cite

Physician treatment selection in the prospective Metastatic Renal Cell Cancer (MaRCC) Registry.

Conference Journal of Clinical Oncology · January 10, 2016 563 Background: Clinical trials mRCC pts are different from real world pts, resulting in bias in the literature. The MaRCC Registry is designed to survey questions not asked in tri als, such as why physicians make certain managem ... Full text Cite

Front-line management patterns in the prospective metastatic renal cell cancer (MaRCC) registry.

Conference Journal of Clinical Oncology · January 10, 2016 617 Background: Over the past decade, seven agents were approved for metastatic renal cell carcinoma (mRCC) leading to a rapidly evolving clinical landscape. Clinical trials addressing treatment efficacy, sequencing, and other qu ... Full text Cite

Radiosurgery for Brain Metastases in Melanoma Patients Receiving Ipilimumab

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: changes in practice patterns after publication of Cancer and Leukemia Group B 9343.

Conference Cancer · January 15, 2015 BACKGROUND: The Cancer and Leukemia Group B (CALGB) 9343 randomized phase 3 trial established lumpectomy and adjuvant therapy with tamoxifen alone, rather than both radiotherapy and tamoxifen, as a reasonable treatment course for women aged >70 years with ... Full text Link to item Cite

A peripheral circulating TH1 cytokine profile is inversely associated with prostate cancer risk in CLUE II.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2014 BACKGROUND: TH1 cytokines, such as IFNγ and TNFα, and potentially innate cytokines, such as IL6, can potentiate the immune response to tumor. Cytokines, such as IL1β, IL8, and IL10, may suppress anticancer immunity. Thus, we prospectively evaluated the ass ... Full text Link to item Cite

Surgical interventions in cancer patients at the end of life: Experiences at an academic medical center.

Journal Article J Clin Oncol · October 20, 2014 281 Background: Surgical quality measures look to reduce variation and improve outcomes. Procedure goals can range from cure to symptom improvement. Knowledge of procedures used in this population can inform quality metrics, ensure palliation is included a ... Full text Link to item Cite

Serum prostate-specific antigen (PSA) concentration is positively associated with rate of disease reclassification on subsequent active surveillance prostate biopsy in men with low PSA density.

Journal Article BJU Int · April 2014 OBJECTIVE: To investigate the association between serum prostate-specific antigen (PSA) concentration at active surveillance (AS) entry and disease reclassification on subsequent AS biopsy ('biopsy reclassification') in men with low PSA density (PSAD). To ... Full text Link to item Cite

Primary care providers' perspectives on discontinuing prostate cancer screening.

Journal Article Cancer · November 15, 2012 BACKGROUND: Clinical guidelines recommend against routine prostate-specific antigen (PSA) screening for older men and for those with lower life expectancies. The authors of this report examined providers' decision-making regarding discontinuing PSA screeni ... Full text Link to item Cite

Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study.

Journal Article Am J Kidney Dis · August 2012 BACKGROUND: Identifying individuals at risk of chronic kidney disease (CKD) is critical for timely treatment initiation to slow progression of the disease. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) are known bio ... Full text Link to item Cite

Comparison of measured GFR, serum creatinine, cystatin C, and beta-trace protein to predict ESRD in African Americans with hypertensive CKD.

Journal Article Am J Kidney Dis · December 2011 BACKGROUND: Identification of persons with chronic kidney disease (CKD) who are at highest risk to progress to end-stage renal disease (ESRD) is necessary to reduce the burden of kidney failure. The relative utility of traditional markers of kidney functio ... Full text Link to item Cite

Lower urinary connective tissue growth factor levels and incident CKD stage 3 in the general population.

Journal Article Am J Kidney Dis · June 2011 BACKGROUND: Connective tissue growth factor (CTGF) is involved in the development and progression of kidney diseases, including diabetic nephropathy and kidney fibrosis, but also may have a role in mesangial repair after injury. It is unknown whether, in t ... Full text Link to item Cite

Trefoil factor 3 predicts incident chronic kidney disease: a case-control study nested within the Atherosclerosis Risk in Communities (ARIC) study.

Journal Article Am J Nephrol · 2011 BACKGROUND: Early detection of individuals at high risk for chronic kidney disease (CKD) may aid prevention. Urinary levels of trefoil factor 3 (TFF3) are associated with acute kidney injury in animal models, but the association of TFF3 levels with inciden ... Full text Link to item Cite

Salvage radiotherapy for rising or persistent PSA after radical prostatectomy.

Journal Article Urology · August 2002 OBJECTIVES: To assess the effectiveness of salvage radiotherapy (RT) for a persistent or rising prostate-specific antigen (PSA) level after radical prostatectomy, and to identify the pretreatment factors that may predict for patients likely to benefit from ... Full text Link to item Cite