Skip to main content

Paul Edmund Wischmeyer

Professor of Anesthesiology
Anesthesiology, Critical Care Medicine

Research Interests


Dr. Wischmeyer’s clinical and research focus is in critical care, COVID-19 care, nutrition, and perioperative care  to help improve outcomes and assist patients in preparing and recovering from critical illness, COVID-19, and surgery.
His research interests include:
1) ICU and surgical nutrition therapy
2) Personalized Exercise Interventions to promote recovery for COVID-19, Long COVID, Critical Care, and Perioperative Care
3) Health Outcome and Large Database research focused on TPN, oral/enteral nutrition, and ICU/surgical outcomes
5) Role of parenteral nutrition in improving outcomes in surgery, trauma, and critical care
6) Perioperative optimization studies
7) Post-illness muscle mass and functional recovery studies
8) Role of probiotics/microbiome in prevention of COVID-19, treating illness and improving cognition.
9) Health Outcome and Large Database research focused on TPN, oral/enteral nutrition, and ICU/surgical outcomes
10) Role of parenteral nutrition in improving outcomes in surgery, trauma, and critical care

Further, we focus on studies of metabolism, indirect calorimetry, novel muscle mass measures via ultrasound and other techniques, and body composition in illnesses including COVID-19, critical care and surgery. Finally, we carry out a range of exercise based and High Intensity Interval training interventions to improve recovery from illness (including COVID-19), from ICU and surgery.

Selected Grants


STUDY TO DEMONSTRATE THE SAFETY AND EFFICACY OF DEFENCATH-Pro00117427

Clinical TrialPrincipal Investigator · Awarded by CorMedix, Inc. · 2025 - 2030

Unraveling effects of gut and blood microbial signatures on immune phenotypes and organ dysfunction in sepsis

ResearchCollaborator · Awarded by National Institutes of Health · 2025 - 2030

Remotely Monitored, Mobile health-supported High Intensity Interval Training after COVID-19 Critical Illness (REMM HIIT-Covid19)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2027

UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEMentor · Awarded by University of North Carolina - Chapel Hill · 2016 - 2026

Integrated Training in Anesthesiology Research

Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1996 - 2026

Role of Nutrition on Gut Microbes and Translocation after Trauma Laparotomy

ResearchMentor · Awarded by International Anesthesia Research Society · 2024 - 2026

Tralement Adult Safety Study TE20001 Pro00114086

Clinical TrialPrincipal Investigator · Awarded by American Regent · 2024 - 2025

The Role of the IL-1 Receptor in the AKI to CKD transition

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2019 - 2024

REmotely Monitored, Mobile-Health High Intensity Interval Training after Critical Care (REMM-HIIT)

Clinical TrialPrincipal Investigator · Awarded by Society of Critical Care Medicine · 2021 - 2024

Effect of Prebiotic Fiber-Enriched Enteral Feeding on the Microbiome in Trauma Patients

Clinical TrialPrincipal Investigator · Awarded by Abbott Nutrition · 2017 - 2023

Longitudinal Evaluation of Energy Expenditure in ICU Patients From Admission to Discharge Using A Novel Indirect Calorimeter: LEEP-Forward Trial

Clinical TrialPrincipal Investigator · Awarded by Baxter Healthcare Corporation · 2019 - 2023

Right Ventricular Metabolic Dysregulation after Surgery for Heart Failure

ResearchCo-Mentor · Awarded by International Anesthesia Research Society · 2021 - 2023

(LEEP-ON) Longitudinal Energy Expenditure in the ICU and Post-ICU Phases in Obese and Non-Obese Hospitalized Patients

ResearchMentor · Awarded by American Society for Parenteral and Enteral Nutrition · 2022 - 2022

Targeting microbially-derived juvenile protective factors to resolve neuroinflammation and delirium

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2019 - 2022

Abbott Nutritional Project

ResearchPrincipal Investigator · Awarded by Abbott Nutrition · 2018 - 2022

The Impact of Race and Socioeconomic Status on Malnutrition in Surgical Patients

ResearchMentor · Awarded by American Society for Parenteral and Enteral Nutrition · 2020 - 2021

Preoperative exercise and nutrition to improve perioperative outcomes (PREvENT) pilot

Clinical TrialPrincipal Investigator · Awarded by Nutricia Research B.V. · 2019 - 2021

Takeda 954-2004 for the Prophylaxis and Treatment of Postop GI Dysfunction

Clinical TrialPrincipal Investigator · Awarded by Takeda Pharmaceuticals North America Inc. · 2019 - 2021

CAPER Support for Paul Wischmeyer Salary

ResearchCo Investigator · Awarded by Institute for Medical Research, Inc. · 2020 - 2020

Preoperative exercise to improve vagal tone (PREVENT) study

ResearchMentor · Awarded by International Anesthesia Research Society · 2019 - 2020

Lyric IV LP101 in patients with enteral feeding intolerance

Clinical TrialPrincipal Investigator · Awarded by Lyric Pharmaceuticals, Inc. · 2016 - 2018

External Relationships


  • ART Medical
  • Abbott Nutrition (Abbott Labs)
  • Baxter Healthcare
  • DSM biomedical
  • Fresenius-Kabi
  • Marius Pharmaceuticals
  • Mend Inc
  • MuscleSound
  • Nutricia

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.