Scholars@Duke
Pengfei Song

Pengfei Song

Visiting Associate Professor in the Department of Biomedical Engineering
Biomedical Engineering
pengfei.song@duke.edu
100 Science Drive, Hudson Hall Annex 276, Durham, NC 27708

Selected Publications

Advanced deep-tissue imaging and manipulation enabled by biliverdin reductase knockout.

Journal Article bioRxiv · October 18, 2024 We developed near-infrared (NIR) photoacoustic and fluorescence probes, as well as optogenetic tools from bacteriophytochromes, and enhanced their performance using biliverdin reductase-A knock-out model (Blvra-/-). Blvra-/- elevates endogenous heme-derive ... Full text Link to item Cite

High-Resolution Power Doppler Using Null Subtraction Imaging.

Journal Article IEEE transactions on medical imaging · September 2024 To improve the spatial resolution of power Doppler (PD) imaging, we explored null subtraction imaging (NSI) as an alternative beamforming technique to delay-and-sum (DAS). NSI is a nonlinear beamforming approach that uses three different apodizations on re ... Full text Cite

ULTRA-SR Challenge: Assessment of Ultrasound Localization and TRacking Algorithms for Super-Resolution Imaging.

Journal Article IEEE transactions on medical imaging · August 2024 With the widespread interest and uptake of super-resolution ultrasound (SRUS) through localization and tracking of microbubbles, also known as ultrasound localization microscopy (ULM), many localization and tracking algorithms have been developed. ULM can ... Full text Cite

Clinical, Safety, and Engineering Perspectives on Wearable Ultrasound Technology: A Review.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · July 2024 Wearable ultrasound has the potential to become a disruptive technology enabling new applications not only in traditional clinical settings, but also in settings where ultrasound is not currently used. Understanding the basic engineering principles and lim ... Full text Cite

Three-Dimensional Shear Wave Elastography Using Acoustic Radiation Force and a 2-D Row-Column Addressing (RCA) Array.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · April 2024 Acoustic radiation force (ARF)-based shear wave elastography (SWE) is a clinically available ultrasound imaging mode that noninvasively and quantitatively measures tissue stiffness. Current implementations of ARF-SWE are largely limited to 2-D imaging, whi ... Full text Cite

Context-aware deep learning enables high-efficacy localization of high concentration microbubbles for super-resolution ultrasound localization microscopy.

Journal Article Nature communications · April 2024 Ultrasound localization microscopy (ULM) enables deep tissue microvascular imaging by localizing and tracking intravenously injected microbubbles circulating in the bloodstream. However, conventional localization techniques require spatially isolated micro ... Full text Cite

Super-Resolution Ultrasound Reveals Cerebrovascular Impairment in a Mouse Model of Alzheimer's Disease.

Journal Article The Journal of neuroscience : the official journal of the Society for Neuroscience · February 2024 Increasing evidence has suggested a link between cerebrovascular disease and the cognitive impairment associated with Alzheimer's disease. However, detailed descriptions of microvascular changes across brain regions and how they relate to other more tradit ... Full text Cite

Joint localization and classification of breast masses on ultrasound images using an auxiliary attention-based framework.

Journal Article Medical image analysis · December 2023 Multi-task learning (MTL) methods have been extensively employed for joint localization and classification of breast lesions on ultrasound images to assist in cancer diagnosis and personalized treatment. One typical paradigm in MTL is a shared trunk networ ... Full text Cite

Contrast-Free Super-Resolution Power Doppler (CS-PD) Based on Deep Neural Networks.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · October 2023 Super-resolution ultrasound microvessel imaging based on ultrasound localization microscopy (ULM) is an emerging imaging modality that is capable of resolving micrometer-scaled vessels deep into tissue. In practice, ULM is limited by the need for contrast ... Full text Cite

Localization Free Super-Resolution Microbubble Velocimetry Using a Long Short-Term Memory Neural Network.

Journal Article IEEE transactions on medical imaging · August 2023 Ultrasound localization microscopy is a super-resolution imaging technique that exploits the unique characteristics of contrast microbubbles to side-step the fundamental trade-off between imaging resolution and penetration depth. However, the conventional ... Full text Cite

High-Volume-Rate 3-D Ultrasound Imaging Using Fast-Tilting and Redirecting Reflectors.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · August 2023 Three-dimensional ultrasound imaging has many advantages over 2-D imaging such as more comprehensive tissue evaluation and less operator dependence. However, developing a low-cost and accessible 3-D ultrasound solution with high volume rate and imaging qua ... Full text Cite

Non-invasive Deep-Brain Imaging with 3D Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy (3D-PAULM).

Journal Article ArXiv · July 27, 2023 Photoacoustic computed tomography (PACT) is a proven technology for imaging hemodynamics in deep brain of small animal models. PACT is inherently compatible with ultrasound (US) imaging, providing complementary contrast mechanisms. While PACT can quantify ... Link to item Cite

High-Level Synthesis Design of Scalable Ultrafast Ultrasound Beamformer With Single FPGA.

Journal Article IEEE transactions on biomedical circuits and systems · June 2023 Ultrafast ultrasound imaging is essential for advanced ultrasound imaging techniques such as ultrasound localization microscopy (ULM) and functional ultrasound (fUS). Current ultrafast ultrasound imaging is challenged by the ultrahigh data bandwidth associ ... Full text Cite

Curvelet Transform-Based Sparsity Promoting Algorithm for Fast Ultrasound Localization Microscopy.

Journal Article IEEE transactions on medical imaging · September 2022 Ultrasound localization microscopy (ULM) based on microbubble (MB) localization was recently introduced to overcome the resolution limit of conventional ultrasound. However, ULM is currently challenged by the requirement for long data acquisition times to ... Full text Cite

Deep Learning-Based Microbubble Localization for Ultrasound Localization Microscopy.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · April 2022 Ultrasound localization microscopy (ULM) is an emerging vascular imaging technique that overcomes the resolution-penetration compromise of ultrasound imaging. Accurate and robust microbubble (MB) localization is essential for successful ULM. In this study, ... Full text Cite

Characterization of Anti-Angiogenic Chemo-Sensitization via Longitudinal Ultrasound Localization Microscopy in Colorectal Carcinoma Tumor Xenografts.

Journal Article IEEE transactions on bio-medical engineering · April 2022 ObjectiveSuper-resolution ultrasound localization microscopy (ULM) has unprecedented vascular resolution at clinically relevant imaging penetration depths. This technology can potentially screen for the transient microvascular changes that are tho ... Full text Cite

Improved Ultrasound Localization Microscopy Based on Microbubble Uncoupling via Transmit Excitation.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · March 2022 Ultrasound localization microscopy (ULM) demonstrates great potential for visualization of tissue microvasculature at depth with high spatial resolution. The success of ULM heavily depends on robust localization of isolated microbubbles (MBs), which can be ... Full text Cite

Pixel-Oriented Adaptive Apodization for Plane-Wave Imaging Based on Recovery of the Complete Dataset.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · February 2022 In theory, coherent plane-wave compounding (CPWC) enables ultrafast ultrasound imaging while maintaining a high imaging quality that is comparable to conventional B-mode imaging based on focused beam transmissions. However, in practice, due to the imperfec ... Full text Cite

Three-Dimensional Shear Wave Elastography Using a 2D Row Column Addressing (RCA) Array.

Journal Article BME frontiers · January 2022 Objective. To develop a 3D shear wave elastography (SWE) technique using a 2D row column addressing (RCA) array, with either external vibration or acoustic radiation force (ARF) as the shear wave source. Impact Statement. The proposed method ... Full text Cite

Noise Suppression for Ultrasound Attenuation Coefficient Estimation Based on Spectrum Normalization.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · August 2021 Ultrasound attenuation coefficient estimation (ACE) has great diagnostic potential for fatty liver detection and assessment. In a previous study, we proposed a reference phantom-free ACE method, called reference frequency method (RFM), which does not requi ... Full text Cite

Simultaneous Noise Suppression and Incoherent Artifact Reduction in Ultrafast Ultrasound Vascular Imaging.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · June 2021 Ultrasound vascular imaging based on ultrafast plane wave imaging and singular value decomposition (SVD) clutter filtering has demonstrated superior sensitivity in blood flow detection. However, ultrafast ultrasound vascular imaging is susceptible to elect ... Full text Cite

Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms.

Journal Article Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · March 2021 ObjectivesTo quantify the bias of shear wave speed (SWS) measurements between different commercial ultrasonic shear elasticity systems and a magnetic resonance elastography (MRE) system in elastic and viscoelastic phantoms.MethodsTwo elas ... Full text Cite

Fast Acoustic Steering Via Tilting Electromechanical Reflectors (FASTER): A Novel Method for High Volume Rate 3-D Ultrasound Imaging.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · March 2021 The 3-D ultrasound imaging is essential for a wide range of clinical applications in diagnostic and interventional cardiology, radiology, and obstetrics for prenatal imaging. 3-D ultrasound imaging is also pivotal for advancing technical developments of em ... Full text Cite

Three-dimensional shear wave elastography on conventional ultrasound scanners with external vibration.

Journal Article Physics in medicine and biology · November 2020 Two-dimensional (2D) ultrasound shear wave elastography (SWE) has been widely used for soft tissue properties assessment. Given that shear waves propagate in three dimensions (3D), extending SWE from 2D to 3D is important for comprehensive and accurate sti ... Full text Cite

Kalman Filter-Based Microbubble Tracking for Robust Super-Resolution Ultrasound Microvessel Imaging.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · September 2020 Contrast microbubble (MB)-based super-resolution ultrasound microvessel imaging (SR-UMI) overcomes the compromise in conventional ultrasound imaging between spatial resolution and penetration depth and has been successfully applied to a wide range of clini ... Full text Cite

In Vivo Confocal Imaging of Fluorescently Labeled Microbubbles: Implications for Ultrasound Localization Microscopy.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · September 2020 We report the time kinetics of fluorescently labeled microbubbles (MBs) in capillary-level microvasculature as measured via confocal microscopy and compare these results to ultrasound localization microscopy (ULM). The observed 19.4 ± 4.2 MBs per confocal ... Full text Cite

Short Acquisition Time Super-Resolution Ultrasound Microvessel Imaging via Microbubble Separation.

Journal Article Scientific reports · April 2020 Super-resolution ultrasound localization microscopy (ULM), based on localization and tracking of individual microbubbles (MBs), offers unprecedented microvascular imaging resolution at clinically relevant penetration depths. However, ULM is currently limit ... Full text Cite

Early Identification of Residual Tumors following Microwave Ablation Using Contrast-Enhanced Ultrasonography in a Rabbit VX2 Liver Cancer Model.

Journal Article BioMed research international · January 2020 ObjectiveIt is difficult to evaluate the ablation effect immediately after thermal ablation of liver cancer by clinical imaging methods, due to the immediate formation of an annular inflammatory reaction band (IRB). This study is aimed at explorin ... Full text Cite

Debiasing-Based Noise Suppression for Ultrafast Ultrasound Microvessel Imaging.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · August 2019 Ultrasound microvessel imaging (UMI) based on the combination of singular value decomposition (SVD) clutter filtering and ultrafast plane wave imaging has recently demonstrated significantly improved Doppler sensitivity, especially to small vessels that ar ... Full text Cite

Noninvasive Contrast-Free 3D Evaluation of Tumor Angiogenesis with Ultrasensitive Ultrasound Microvessel Imaging.

Journal Article Scientific reports · March 2019 Ultrasound microvessel imaging (UMI), when applied with ultrafast planewave acquisitions, has demonstrated superior blood signal sensitivity in comparison to conventional Doppler imaging. Here we propose a high spatial resolution and ultra-sensitive UMI th ... Full text Cite

Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study.

Journal Article Frontiers in neurology · January 2019 This study presents the first implementation of functional ultrasound (fUS) imaging of the spinal cord to monitor local hemodynamic response to epidural electrical spinal cord stimulation (SCS) on two small and large animal models. SCS has been successfull ... Full text Cite

On the Effects of Spatial Sampling Quantization in Super-Resolution Ultrasound Microvessel Imaging.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · December 2018 Ultrasound super-resolution (SR) microvessel imaging technologies are rapidly emerging and evolving. The unprecedented combination of imaging resolution and penetration promises a wide range of preclinical and clinical applications. This paper concerns spa ... Full text Cite

Spatiotemporal clutter filtering methods for in vivo microvessel imaging

Journal Article The Journal of the Acoustical Society of America · March 1, 2018 Ultrafast plane wave imaging enables acquisition and accumulation of a large number of Doppler ensembles in a short period of time, which substantially boosts ultrasound Doppler sensitivity by at least an order of magnitude. As a key component, spa ... Full text Cite

Robust Phase Velocity Dispersion Estimation of Viscoelastic Materials Used for Medical Applications Based on the Multiple Signal Classification Method.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · March 2018 Ultrasound shear wave elastography (SWE) is emerging as a promising imaging modality for the noninvasive evaluation of tissue mechanical properties. One of the ways to explore the viscoelasticity is through analyzing the shear wave velocity dispersion curv ... Full text Cite

Improved Super-Resolution Ultrasound Microvessel Imaging With Spatiotemporal Nonlocal Means Filtering and Bipartite Graph-Based Microbubble Tracking.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · February 2018 Super-resolution ultrasound microvessel imaging with contrast microbubbles has recently been proposed by multiple studies, demonstrating outstanding resolution with high potential for clinical applications. This paper aims at addressing the potential noise ... Full text Cite

Noise Equalization for Ultrafast Plane Wave Microvessel Imaging.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · November 2017 Ultrafast plane wave microvessel imaging significantly improves ultrasound Doppler sensitivity by increasing the number of Doppler ensembles that can be collected within a short period of time. The rich spatiotemporal plane wave data also enable more robus ... Full text Cite

Hadamard-Encoded Multipulses for Contrast-Enhanced Ultrasound Imaging.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · November 2017 The development of contrast-enhanced ultrasound (CEUS) imaging offers great opportunities for new ultrasound clinical applications such as myocardial perfusion imaging and abdominal lesion characterization. In CEUS imaging, the contrast agents (i.e., micro ... Full text Cite

Notice of Removal: Fast and robust spatiotemporal microvessel clutter filtering with randomized singular value decomposition (rSVD) and randomized spatial downsampling

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Singular value decomposition (SVD)-based clutter filtering has demonstrated superior clutter rejection performance in the emerging field of ultrasound microvessel imaging. To alleviate the computational burden of SVD, here we present a fast and robust clut ... Full text Cite

A model-free approach to probe motion artifacts suppression for in vivo imaging with probe oscillation shear wave elastography (PROSE)

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Probe oscillation shear wave elastography (PROSE) can achieve high frame-rate two-dimensional (2D) shear wave elastography by utilizing a continuously vibrating ultrasound probe to simultaneously generate and detect shear waves (Mellema, IEEE TMI 0278-0062 ... Full text Cite

Delay-encoded harmonic imaging (DE-HI) in multiplane-wave compounding

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 The development of ultrafast ultrasound imaging brings great opportunities to improve imaging technologies such as shear wave elastography and ultrafast Doppler imaging. In ultrafast imaging, there are trade-offs among image signal-to-noise ratio (SNR), re ... Full text Cite

Notice of Removal: Robust ultrasound super-resolution microvessel imaging with spatiotemporal nonlocal means filtering and bipartite graph-based microbubble tracking

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Recently multiple studies have demonstrated microbubble (MB)-based super-resolution imaging (SRI) with ∼λ/10 subwavelength resolution on mice and rats. Clinical translation of SRI, however, faces many technical challenges such as low signal-to-noise-ratio ... Full text Cite

Delay-encoded harmonic imaging (DE-HI) in multiplane-wave compounding

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Ultrafast ultrasound imaging offers great opportunities to new imaging technologies such as shear wave elastography and ultrafast Doppler. Multiplane wave (MW) imaging is a new technique in which multiple positively or negatively encoded plane waves are em ... Full text Cite

Hadamard-encoded multi-pulses for contrast-enhanced ultrasound imaging

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 The development of contrast-enhanced ultrasound (CEUS) imaging has great potential for use in new ultrasound clinical applications such as myocardial perfusion imaging and abdominal lesion characterization. In CEUS imaging, the contrast agents (i.e., micro ... Full text Cite

Improved contrast-enhanced ultrasound imaging with multiplane wave imaging

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Contrast enhanced ultrasound (CEUS) imaging offers great opportunities for new ultrasound applications by improving the contrast between blood and tissue using microbubbles. However, the low signal-to-noise ratio (SNR) due to the low mechanical index (MI) ... Full text Cite

Improved contrast-enhanced ultrasound imaging with multiplane wave imaging

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Contrast-enhanced ultrasound (CEUS) imaging offers great opportunities for new ultrasound applications by improving the contrast between blood and tissue using microbubbles. However, the low signal-to-noise ratio (SNR) due to the low mechanical index (MI) ... Full text Cite

Hadamard encoded multi-pulses for contrast enhanced ultrasound imaging

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Contrast enhanced ultrasound (CEUS) imaging is widely used in clinic to enhance blood flow signal using microbubbles (MBs). In conventional CEUS methods such as pulse inversion (PI), amplitude modulation (AM), and pulse inversion amplitude modulation (PIAM ... Full text Cite

Notice of Removal: Singular value decomposition-based noise equalization for ultrafast plane wave microvessel imaging

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Ultrafast plane wave microvessel imaging significantly improves ultrasound Doppler sensitivity. The rich spatiotemporal plane wave data enables robust clutter filtering based on singular value decomposition (SVD). However, due to the lack of transmit focus ... Full text Cite

Ultrafast Synthetic Transmit Aperture Imaging Using Hadamard-Encoded Virtual Sources With Overlapping Sub-Apertures.

Journal Article IEEE transactions on medical imaging · June 2017 The development of ultrafast ultrasound imaging offers great opportunities to improve imaging technologies, such as shear wave elastography and ultrafast Doppler imaging. In ultrafast imaging, there are tradeoffs among image signal-to-noise ratio (SNR), re ... Full text Cite

Quantifying spasticity in individual muscles using shear wave elastography.

Journal Article Radiology case reports · June 2017 Spasticity is common following stroke; however, high subject variability and unreliable measurement techniques limit research and treatment advances. Our objective was to investigate the use of shear wave elastography (SWE) to characterize the spastic refl ... Full text Cite

Delay-Encoded Harmonic Imaging (DE-HI) in Multiplane-Wave Compounding.

Journal Article IEEE transactions on medical imaging · April 2017 The development of ultrafast ultrasound imaging brings great opportunities to improve imaging technologies such as shear wave elastography and ultrafast Doppler imaging. In ultrafast imaging, several tilted plane or diverging wave images are coherently com ... Full text Cite

Accelerated Singular Value-Based Ultrasound Blood Flow Clutter Filtering With Randomized Singular Value Decomposition and Randomized Spatial Downsampling.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · April 2017 Singular value decomposition (SVD)-based ultrasound blood flow clutter filters have recently demonstrated substantial improvement in clutter rejection for ultrafast plane wave microvessel imaging, and have become the commonly used clutter filtering method ... Full text Cite

Ultrasound Small Vessel Imaging With Block-Wise Adaptive Local Clutter Filtering.

Journal Article IEEE transactions on medical imaging · January 2017 Robust clutter filtering is essential for ultrasound small vessel imaging. Eigen-based clutter filtering techniques have recently shown great improvement in clutter rejection over conventional clutter filters in small animals. However, for in vivo human im ... Full text Cite

Quantifying passive muscle stiffness in children with and without cerebral palsy using ultrasound shear wave elastography.

Journal Article Developmental medicine and child neurology · December 2016 AimThe aim of this study was to compare passive muscle stiffness in children with cerebral palsy (CP) and children with typical development using a novel ultrasound technique: ultrasound shear wave elastography (SWE).MethodWe conducted a ... Full text Cite

Quantitative Evaluation of Passive Muscle Stiffness in Chronic Stroke.

Journal Article American journal of physical medicine & rehabilitation · December 2016 ObjectiveThe aim of this study was to evaluate the potential for shear wave elastography (SWE) to measure passive biceps brachii individual muscle stiffness as a musculoskeletal manifestation of chronic stroke.DesignThis was a cross-secti ... Full text Cite

Probe Oscillation Shear Elastography (PROSE): A High Frame-Rate Method for Two-Dimensional Ultrasound Shear Wave Elastography.

Journal Article IEEE transactions on medical imaging · September 2016 Ultrasound shear wave elastography (SWE) utilizes the propagation of induced shear waves to characterize the shear modulus of soft tissue. Many methods rely on an acoustic radiation force (ARF) "push beam" to generate shear waves. However, specialized hard ... Full text Cite

Advanced ultrafast imaging with synthetic transmit aperture (USTA) imaging

Conference 2016 IEEE International Ultrasonics Symposium (IUS) · September 2016 Full text Cite

Pediatric Cardiac Shear Wave Elastography for Quantitative Assessment of Myocardial Stiffness: A Pilot Study in Healthy Controls.

Journal Article Ultrasound in medicine & biology · August 2016 The long-term goal of this study is to assess chemotherapy-induced cardiotoxicity for pediatric cancer patients using cardiac ultrasound shear wave (SW) elastography. This pilot study aimed to systematically investigate the feasibility of using cardiac SW ... Full text Cite

Quantitative Assessment of Left Ventricular Diastolic Stiffness Using Cardiac Shear Wave Elastography: A Pilot Study.

Journal Article Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · July 2016 ObjectivesThe purpose of this study was to systematically investigate the feasible echocardiographic views for human transthoracic cardiac shear wave elastography (SWE) and the impact of myocardial anisotropy on myocardial stiffness measurements.< ... Full text Cite

Improvement of Shear Wave Motion Detection Using Harmonic Imaging in Healthy Human Liver.

Journal Article Ultrasound in medicine & biology · May 2016 Quantification of liver elasticity is a major application of shear wave elasticity imaging (SWEI) to non-invasive assessment of liver fibrosis stages. SWEI measurements can be highly affected by ultrasound image quality. Ultrasound harmonic imaging has exh ... Full text Cite

Performance of 2-Dimensional Ultrasound Shear Wave Elastography in Liver Fibrosis Detection Using Magnetic Resonance Elastography as the Reference Standard: A Pilot Study.

Journal Article Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · February 2016 ObjectivesTo investigate the correlation between 2-dimensional (2D) ultrasound shear wave elastography (SWE) and magnetic resonance elastography (MRE) in liver stiffness measurement and the diagnostic performance of 2D SWE for liver fibrosis when ... Full text Cite

Investigation of the effects of myocardial anisotropy for shear wave elastography using impulsive force and harmonic vibration.

Journal Article Physics in medicine and biology · January 2016 The myocardium is known to be an anisotropic medium where the muscle fiber orientation changes through the thickness of the wall. Shear wave elastography methods use propagating waves which are measured by ultrasound or magnetic resonance imaging (MRI) tec ... Full text Cite

RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media

Conference 2015 IEEE International Ultrasonics Symposium, IUS 2015 · November 13, 2015 Using ultrasonic shear wave speed (SWS) estimates has become popular to noninvasively evaluate liver fibrosis, but significant inter-system variability in liver SWS measurements can preclude meaningful comparison of measurements performed with different sy ... Full text Cite

A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography

Conference 2015 IEEE International Ultrasonics Symposium, IUS 2015 · November 13, 2015 Recent advancement in cardiac shear wave elastography (SWE) using pulse-inversion harmonic imaging showed substantial improvement of shear wave motion detection and demonstrated feasibility of transthoracic measurement of human myocardial stiffness. This s ... Full text Cite

In vivo liver shear wave motion detection and shear wave speed comparison between fundamental and harmonic imaging

Conference 2015 IEEE International Ultrasonics Symposium, IUS 2015 · November 13, 2015 Quantification of liver elasticity is a major application of shear wave elasticity imaging (SWEI) to non-invasively assess liver fibrosis stages. SWEI measurements can be highly affected by ultrasound image quality. Ultrasound harmonic imaging has shown a ... Full text Cite

Implementation of shear wave elastography on pediatric cardiac transducers with pulse-inversion harmonic imaging and time-aligned sequential tracking

Conference 2015 IEEE International Ultrasonics Symposium, IUS 2015 · November 13, 2015 Monitoring myocardial stiffness changes with shear wave elastography (SWE) has promising potential for assessing chemotherapy-induced cardiotoxicity for pediatric cancer patients. While ultrasound B-scan with adult cardiac probes on children is commonly ac ... Full text Cite

A high frame-rate and low-cost Elastography system by generating shear waves through continuous vibration of the ultrasound transducer

Conference 2015 IEEE International Ultrasonics Symposium, IUS 2015 · November 13, 2015 Ultrasound shear wave elastography (SWE) utilizes the propagation of induced shear waves to characterize the shear modulus of soft tissue. Many methods rely on an acoustic radiation force (ARF) push beam to generate shear waves. However, specialized hardwa ... Full text Cite

Investigation of the effects of myocardial anisotropy for shear wave elastography using acoustic radiation force and harmonic vibration

Conference 2015 IEEE International Ultrasonics Symposium, IUS 2015 · November 13, 2015 Shear wave elastography with acoustic radiation force (ARF) or harmonic vibration (HV) has been applied in animals and humans to evaluate myocardial material properties. The anisotropic myocardial structure presents a unique challenge to wave propagation m ... Full text Cite

Update on Breast Cancer Detection Using Comb-Push Ultrasound Shear Elastography.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · September 2015 In this work, tissue stiffness estimates are used to differentiate between benign and malignant breast masses in a group of pre-biopsy patients. The rationale is that breast masses are often stiffer than healthy tissue; furthermore, malignant masses are st ... Full text Cite

Coded excitation plane wave imaging for shear wave motion detection.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · July 2015 Plane wave imaging has greatly advanced the field of shear wave elastography thanks to its ultrafast imaging frame rate and the large field-of-view (FOV). However, plane wave imaging also has decreased penetration due to lack of transmit focusing, which ma ... Full text Cite

Feasibility and reliability of quantifying passive muscle stiffness in young children by using shear wave ultrasound elastography.

Journal Article Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · April 2015 ObjectivesThe purpose of this study was to investigate the feasibility and reliability of passive muscle stiffness measurements in children by shear wave ultrasound elastography.MethodsWe conducted a prospective cross-sectional study quan ... Full text Cite

Multi-source and multi-directional shear wave generation with intersecting steered ultrasound push beams.

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · April 2015 Elasticity imaging is becoming established as a means of assisting in diagnosis of certain diseases. Shear wave-based methods have been developed to perform elasticity measurements in soft tissue. Comb-push ultrasound shear elastography (CUSE) is one of th ... Full text Cite

2083648 Robust and Ultrafast Detection of Shear Wave Motion Using Coded Excitation

Journal Article Ultrasound in Medicine & Biology · April 2015 Full text Cite

Feasibility assessment of shear wave elastography to rotator cuff muscle.

Journal Article Clinical anatomy (New York, N.Y.) · March 2015 Pre-surgical measurement of supraspinatus muscle extensibility is important for rotator cuff repair. The purpose of the present study was to explore the potential feasibility of a shear wave ultrasound elastography (SWE)-based method, combined with B-mode ... Full text Cite

Superficial ultrasound shear wave speed measurements in soft and hard elasticity phantoms: repeatability and reproducibility using two ultrasound systems.

Journal Article Pediatric radiology · March 2015 BackgroundThere is a paucity of data available regarding the repeatability and reproducibility of superficial shear wave speed (SWS) measurements at imaging depths relevant to the pediatric population.ObjectiveTo assess the repeatability ... Full text Cite

Two-dimensional shear-wave elastography on conventional ultrasound scanners with time-aligned sequential tracking (TAST) and comb-push ultrasound shear elastography (CUSE).

Journal Article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · February 2015 Two-dimensional shear-wave elastography presents 2-D quantitative shear elasticity maps of tissue, which are clinically useful for both focal lesion detection and diffuse disease diagnosis. Realization of 2-D shear-wave elastography on conventional ultraso ... Full text Cite

Comb-push ultrasound shear elastography of breast masses: initial results show promise.

Journal Article PloS one · January 2015 Purpose or objectiveTo evaluate the performance of Comb-push Ultrasound Shear Elastography (CUSE) for classification of breast masses.Materials and methodsCUSE is an ultrasound-based quantitative two-dimensional shear wave elasticity imag ... Full text Cite

Comb-push ultrasound shear elastography (CUSE) for evaluation of thyroid nodules: preliminary in vivo results.

Journal Article IEEE transactions on medical imaging · January 2015 In clinical practice, an overwhelming majority of biopsied thyroid nodules are benign. Therefore, there is a need for a complementary and noninvasive imaging tool to provide clinically relevant diagnostic information about thyroid nodules to reduce the rat ... Full text Cite

Shear wave elastography of passive skeletal muscle stiffness: influences of sex and age throughout adulthood.

Journal Article Clinical biomechanics (Bristol, Avon) · January 2015 BackgroundNumerous structural and compositional changes - related not only to age, but also activity level and sex - may affect skeletal muscle stiffness across the adult age-span. Measurement techniques available thus far have largely limited pas ... Full text Cite

External vibration multi-directional ultrasound shearwave elastography (EVMUSE): application in liver fibrosis staging.

Journal Article IEEE transactions on medical imaging · November 2014 Shear wave speed can be used to assess tissue elasticity, which is associated with tissue health. Ultrasound shear wave elastography techniques based on measuring the propagation speed of the shear waves induced by acoustic radiation force are becoming pro ... Full text Cite

Ultrasound elastography: the new frontier in direct measurement of muscle stiffness.

Journal Article Archives of physical medicine and rehabilitation · November 2014 The use of brightness-mode ultrasound and Doppler ultrasound in physical medicine and rehabilitation has increased dramatically. The continuing evolution of ultrasound technology has also produced ultrasound elastography, a cutting-edge technology that can ... Full text Cite

Dual-frequency shear wave motion detection

Conference IEEE International Ultrasonics Symposium, IUS · October 20, 2014 Shear wave motion detection is a critical part of ultrasound shear wave elastography (SWE). Shear wave signal-to-noise-ratio (SNR) is strongly related to the ultrasound RF (radiofrequency) signal SNR. Recently, we demonstrated substantial improvement of sh ... Full text Cite

In vivo transthoracic measurement of end-diastolic left ventricular stiffness with ultrasound shear wave elastography: A pilot study

Conference IEEE International Ultrasonics Symposium, IUS · October 20, 2014 End-diastolic left ventricular (EDLV) stiffness is a strong biomarker of diastolic heart failure (DHF). Ultrasound shear wave elastography (SWE) can provide a quantitative and noninvasive measure of myocardial stiffness, which makes SWE a promising tool fo ... Full text Cite

Comb-Push Ultrasound Shear Elastography of thyroid: Preliminary in vivo human study

Conference IEEE International Ultrasonics Symposium, IUS · October 20, 2014 Shear wave elastography (SWE) techniques have been introduced and have shown promising potency in providing diagnostic information about thyroid nodules. Comb-push Ultrasound Shear Elastography (CUSE) has been recently introduced as a technique that is cap ... Full text Cite

Liver elasticity imaging using external Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE)

Conference IEEE International Ultrasonics Symposium, IUS · October 20, 2014 Shear wave speed can be used to assess tissue elasticity, which is associated with tissue health. Ultrasound shear wave elastography techniques based on measuring the propagation speed of the shear waves induced by acoustic radiation force are becoming pro ... Full text Cite

Shear wave generation with steered ultrasound push beams

Conference IEEE International Ultrasonics Symposium, IUS · October 20, 2014 Elasticity imaging is becoming established as a means of assisting in diagnosis of certain diseases. Shear wave-based methods have been developed to perform elasticity measurements in soft tissue. We propose a novel method that uses steered push beams (SPB ... Full text Cite

Shear wave elastography on the GE LOGIQ E9 with Comb-push Ultrasound Shear Elastography (CUSE) and time aligned sequential tracking (TAST)

Conference IEEE International Ultrasonics Symposium, IUS · October 20, 2014 Two-dimensional (2D) shear wave elastography has emerged as a popular clinical and research tool for a variety of applications. Implementing 2D shear wave elastography on a conventional ultrasound scanner, however, is a challenging task due to the low imag ... Full text Cite

Fast shear compounding using robust 2-D shear wave speed calculation and multi-directional filtering.

Journal Article Ultrasound in medicine & biology · June 2014 A fast shear compounding method was developed in this study using only one shear wave push-detect cycle, such that the shear wave imaging frame rate is preserved and motion artifacts are minimized. The proposed method is composed of the following steps: 1. ... Full text Cite

RSNA/QIBA: Shear wave speed as a biomarker for liver fibrosis staging

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2013 An interlaboratory study of shear wave speed (SWS) estimation was performed. Commercial shear wave elastography systems from Fibroscan, Philips, Siemens and Supersonic Imagine, as well as several custom laboratory systems, were involved. Fifteen sites were ... Full text Cite

Improved Shear Wave Motion Detection Using Pulse-Inversion Harmonic Imaging With a Phased Array Transducer.

Journal Article IEEE transactions on medical imaging · December 2013 Ultrasound tissue harmonic imaging is widely used to improve ultrasound B-mode imaging quality thanks to its effectiveness in suppressing imaging artifacts associated with ultrasound reverberation, phase aberration, and clutter noise. In ultrasound shear w ... Full text Cite

Two-dimensional shear elasticity imaging using external mechanical vibration

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2013 Compared to ultrasound radiation force, mechanical vibration is capable of delivering larger motion into deep tissues. However, the propagation direction of the shear waves generated by such method can be complicated and unpredictable, which make it diffic ... Full text Cite

Fast shear compounding using directional filtering and two-dimensional shear wave speed calculation

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2013 Shear compounding illuminates the shear wave imaging field with differently angled shear waves from which elasticity maps can be reconstructed and compounded to increase SNR and contrast. However, the shear imaging frame rate may be reduced by the need for ... Full text Cite

Validation of shear wave elastography in skeletal muscle.

Journal Article Journal of biomechanics · September 2013 Skeletal muscle is a very dynamic tissue, thus accurate quantification of skeletal muscle stiffness throughout its functional range is crucial to improve the physical functioning and independence following pathology. Shear wave elastography (SWE) is an ult ... Full text Cite

Comb-push ultrasound shear elastography (CUSE) with various ultrasound push beams.

Journal Article IEEE transactions on medical imaging · August 2013 Comb-push ultrasound shear elastography (CUSE) has recently been shown to be a fast and accurate 2-D elasticity imaging technique that can provide a full field-of-view (FOV) shear wave speed map with only one rapid data acquisition. The initial version of ... Full text Cite

Patellar tendon morphology in volleyball athletes with and without patellar tendinopathy.

Journal Article Scandinavian journal of medicine & science in sports · March 2013 Appropriate management of patellar tendinopathy requires distinguishing between inflammatory and degenerative conditions, often difficult because tendon thickening can be a normal or pathological adaptation, and micromorphology is not observable on clinica ... Full text Cite

A phantom study to cross-validate multimodality shear wave elastography techniques

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2012 As various quantitative shear wave elastography techniques are being implemented commercially and used clinically, it is important to understand what elastic modulus is measured by those techniques and to assess technical factors influencing measurement ac ... Full text Cite

Shear wave speed measurement using repeated short push pulses

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2012 Measurement of shear wave propagation speed in tissues has clinical significance of indicating tissue stiffness and health state. Shear waves are usually produced by a high voltage, long duration ultrasound push beam. Many ultrasound scanners cannot produc ... Full text Cite

Measure elasticity and viscosity using the out-of-plane shear wave

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2012 Tissue elasticity μ1 and viscosity μ2 can be estimated by evaluating dispersion of shear wave propagation velocity over a range of frequencies. Alternatively, μ1 and μ2 can be calculated from shear wave attenuation αs and velocity cs at a single frequency. ... Full text Cite

Comb-push Ultrasound Shear Elastography (CUSE): A novel and fast technique for shear elasticity imaging

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2012 Multiple push-detect acquisitions are typically required in current acoustic radiation force based shear wave elasticity imaging methods to reconstruct a full FOV elasticity map, which can result in potential motion artifacts and difficulties in studying t ... Full text Cite

Comb-push ultrasound shear elastography (CUSE): a novel method for two-dimensional shear elasticity imaging of soft tissues.

Journal Article IEEE transactions on medical imaging · September 2012 Fast and accurate tissue elasticity imaging is essential in studying dynamic tissue mechanical properties. Various ultrasound shear elasticity imaging techniques have been developed in the last two decades. However, to reconstruct a full field-of-view 2-D ... Full text Cite

Shear wave speed measurement using an unfocused ultrasound beam.

Journal Article Ultrasound in medicine & biology · September 2012 Tissue elasticity is related to pathology and, therefore, has important medical applications. Radiation force from a focused ultrasound beam has been used to produce shear waves in tissues for shear wave speed and tissue elasticity measurements. The feasib ... Full text Cite

Robust shear wave speed measurement using comb-push ultrasound radiation force

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2011 Measurement of shear wave propagation speed in tissues has clinical significance of indicating tissue stiffness and health state. Spatially Modulated Ultrasound Radiation Force (SMURF) imaging generates a shear wave of known wavelength in the tested materi ... Full text Cite

Shear wave speed measurements using ultrasound radiation force can be depth dependent

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2011 Measurement of shear wave propagation speed has important clinical applications because it is related to tissue stiffness and health state. Shear waves can be generated in tissue by the radiation force of a focused ultrasound beam (push beam). Shear wave s ... Full text Cite

Shear wave speed measurement using an unfocused ultrasound push beam

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2011 Tissue viscoelasticity is related to pathology and therefore has important medical applications. Radiation force from a focused ultrasound beam has been used to produce shear wave in tissues for shear wave speed and tissue elasticity measurements. The feas ... Full text Cite

Bias observed in time-of-flight shear wave speed measurements using radiation force of a focused ultrasound beam.

Journal Article Ultrasound in medicine & biology · November 2011 Measurement of shear wave propagation speed has important clinical applications because it is related to tissue stiffness and health state. Shear waves can be generated in tissues by the radiation force of a focused ultrasound beam (push beam). Shear wave ... Full text Cite

Two-dimensional shear elasticity imaging using comb-push acoustic radiation force and algebraic direct inversion of the motion differential equation

Journal Article The Journal of the Acoustical Society of America · October 1, 2011 Tissue mechanical properties can be obtained by algebraic direct inversion (ADI) of the shear-wave motion differential equation, which is insensitive to reflection and geometry of the pushing beam. Shear waves normally generated by a focused ultras ... Full text Cite

Single molecule diffusion coefficient estimation by image analysis of simulated CCD images to aid high-throughput screening.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2009 Extension of one-dimensional signal analysis to two-dimensional image analysis could accelerate conventional methods of high-throughput screening in the discovery of new pharmaceutical agents. This work describes a first step taken towards this goal - the ... Full text Cite

Tendinopathy discrimination using spatial frequency parameters and artificial neural networks

Conference Proceedings - IEEE Ultrasonics Symposium · January 1, 2009 Healthy tendon's structural characteristics are related to the anisotropic speckle pattern observed in ultrasound images. This speckle orientation is disrupted upon damage to the tendon structure as observed in patients with tendinopathy. Quantification of ... Full text Cite

Automatic skeletonization for 3D hepatic portal vein in CT angiography

Conference IEEE Nuclear Science Symposium Conference Record · December 1, 2008 The analysis of Hepatic Portal Vein (HPV) is important in liver surgical planning and diseases diagnosis, such as living-related liver transplant and oncologic resections. Skeletonization is always the necessary way for vasculature quantification analysis. ... Full text Cite