Scholars@Duke
Piers Christopher Andrew Barker

Piers Christopher Andrew Barker

Professor of Pediatrics
Pediatrics, Cardiology
piers.barker@duke.edu
Box 3090 Med Ctr, Durham, NC
7605-A Hosp North, Durham, NC

Selected Publications

Obesity Predisposes Anthracycline-Treated Survivors of Childhood and Adolescent Cancers to Subclinical Cardiac Dysfunction.

Journal Article Pediatr Cardiol · February 2025 Anthracyclines are effective chemotherapeutics used in approximately 60% of pediatric cancer cases but have a well-documented risk of cardiotoxicity. Existing cardiotoxicity risk calculators do not include cardiovascular risk factors present at the time of ... Full text Link to item Cite

Correlating Severity of Pulmonary Hypertension by Echocardiogram with Mortality in Premature Infants with Bronchopulmonary Dysplasia.

Journal Article Am J Perinatol · December 2024 OBJECTIVE:  Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth. Infants with BPD are at increased risk for pulmonary hypertension (PH). Cardiac catheterization is the gold standard for diagnosing PH, but cardiac catheterizati ... Full text Link to item Cite

Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure.

Journal Article Cardiovasc Eng Technol · August 2024 PURPOSR: This study created 3D CFD models of the Norwood procedure for hypoplastic left heart syndrome (HLHS) using standard angiography and echocardiogram data to investigate the impact of shunt characteristics on pulmonary artery (PA) hemodynamics. Lever ... Full text Link to item Cite

Detection of occult thrombosis in individuals with Fontan circulation by cardiac MRI.

Journal Article Cardiol Young · July 2024 OBJECTIVE: Identifying thrombus formation in Fontan circulation has been highly variable, with reports between 17 and 33%. Initially, thrombus detection was mainly done through echocardiograms. Delayed-enhancement cardiac MRI is emerging as a more effectiv ... Full text Link to item Cite

Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment.

Journal Article AIDS · June 1, 2024 People with HIV are at increased risk of cardiac dysfunction; however, limited tools are available to identify patients at highest risk for future cardiac disease. We performed proteomic profiling using plasma samples from children and young adults with pe ... Full text Link to item Cite

Diffuse myocardial fibrosis is uncommon in people with perinatally acquired human immunodeficiency virus infection.

Journal Article AIDS Res Ther · March 4, 2024 BACKGROUND: Cardiovascular disease (CVD) remains a leading cause of death in people living with HIV. Myocardial fibrosis is well-described in HIV infection acquired in adulthood. We evaluate the burden of fibrosis by cardiac magnetic resonance in people wi ... Full text Link to item Cite

Guidelines for Performing a Comprehensive Pediatric Transthoracic Echocardiogram: Recommendations From the American Society of Echocardiography.

Journal Article J Am Soc Echocardiogr · February 2024 Echocardiography is a fundamental component of pediatric cardiology, and appropriate indications have been established for its use in the setting of suspected, congenital, or acquired heart disease in children. Since the publication of guidelines for pedia ... Full text Link to item Cite

Coronary Artery Aneurysm Rupture in Kawasaki Disease and SARS-CoV-2 Infection.

Journal Article CASE (Phila) · February 2024 • CAA rupture is a rare, life-threatening complication of KD. • SARS-CoV-2 and KD may have a synergistic effect resulting in severe inflammation. • Recognizing specific echocardiogram findings is necessary to diagnosis CAA rupture. ... Full text Open Access Link to item Cite

Development of right ventricular electromechanical dyssynchrony following surgical repair of tetralogy of Fallot in infants

Journal Article Frontiers in Pediatrics · January 1, 2024 Background: In adolescents and adults with tetralogy of Fallot (TOF), right ventricle (RV) electromechanical dyssynchrony (EMD) due to right bundle branch block (RBBB) is associated with reduced exercise capacity and RV dysfunction. While the development o ... Full text Cite

Diffuse Myocardial Fibrosis is Uncommon in People with Perinatally Acquired Human Immunodeficiency Virus Infection.

Journal Article Res Sq · September 26, 2023 BACKGROUND: Cardiovascular disease (CVD) remains a leading cause of death in people living with HIV. Myocardial fibrosis is well-described in HIV infection acquired in adulthood. We evaluate the burden of fibrosis by cardiac magnetic resonance in people wi ... Full text Link to item Cite

Myocardial Enhancement Following Agitated Saline Contrast Study in a Boxer Dog.

Journal Article CASE (Phila) · July 2023 • Myocardial enhancement after agitated saline contrast study in a dog is described. • Suspect air microemboli can inadvertently be introduced into coronary vasculature. • Air microemboli are a theoretic risk of saline contrast echocardiography. ... Full text Link to item Cite

Ultrasound Visualization and Recording of Transient Myocardial Vibrations.

Journal Article Ultrasound Med Biol · June 2023 OBJECTIVE: A new visualization and recording method used to assess and quantitate autogenic high-velocity motions in myocardial walls to provide a new description of cardiac function is described. METHODS: The regional motion display (RMD) is based on high ... Full text Link to item Cite

Whole-Chest Three-Dimensional Modeling Aids Hybrid Pulmonary Valve Replacement Following Double Switch Operation.

Journal Article World J Pediatr Congenit Heart Surg · January 2023 The double switch operation for congenitally corrected transposition of the great arteries (CC-TGA) has been associated with high rates of reintervention, including the need for pulmonary valve replacement. Hybrid interventional approaches can avoid bypass ... Full text Link to item Cite

Characterization of hemodynamics in anomalous aortic origin of coronary arteries using patient-specific modeling.

Journal Article J Biomech · February 2022 The anomalous aortic origin of coronary arteries (AAOCA) is a congenital disease that can lead to sudden cardiac death (SCD) during strenuous physical activity. Despite AAOCA being the second leading cause of SCD among young athletes, the mechanism behind ... Full text Link to item Cite

Three-dimensional modeling of the mitral valve for surgical planning in a pediatric patient: A case-based discussion of the technical challenges of segmentation and printing from 3D transthoracic echocardiographic datasets.

Journal Article Echocardiography · November 2021 Abnormal atrioventricular valve present great challenges to the surgeon in achieving a successful repair, and thus present a great opportunity for enhanced 3D imaging to guide pre- and intra-operative management. Spatial and temporal resolution of 3D echoc ... Full text Link to item Cite

ASE Statement on Adapting Pediatric, Fetal, and Congenital Heart Disease Echocardiographic Services to the Evolving COVID-19 Pandemic.

Journal Article J Am Soc Echocardiogr · May 2021 Over the 12 months since the start of the coronavirus disease 2019 pandemic, an explosion of investigation and an increase in experience have led to vast improvement in our knowledge about this disease. However, coronavirus disease 2019 remains a huge publ ... Full text Link to item Cite

Echocardiographic Imaging

Chapter · March 2021 Jerry J. Zimmerman and Alexandre T. Rotta, along with an expert team of editors and contributors from around the world, have carefully updated the 6th Edition of this highly regarded text to bring you the most authoritative and useful ... ... Cite

Congenital Anomalies of the Coronary Arteries

Chapter · January 1, 2021 This chapter reviews the imaging of coronary artery anomalies of importance to the pediatric cardiologist with a focus on echocardiography. Embryologic development of the coronary arteries extends from the endocardial sinuses to the epicardial network. The ... Full text Cite

A Randomized, Controlled Pharmacokinetic and Pharmacodynamics Trial of Ambrisentan After Fontan Surgery.

Journal Article Pediatr Crit Care Med · September 2020 OBJECTIVES: To determine the pharmacokinetics, pharmacodynamics, and safety of the hepatically metabolized endothelin receptor antagonist, ambrisentan in children after Fontan surgery. DESIGN: Prospective, randomized, double-blind, placebo-controlled pharm ... Full text Link to item Cite

PCHD Council Year-in-Review.

Journal Article J Am Soc Echocardiogr · September 2020 Full text Link to item Cite

Left-sided congenitally unguarded tricuspid valve with congenitally corrected transposition of the great arteries: A rare diagnosis confirmed by three-dimensional echocardiography.

Journal Article Echocardiography · July 2020 Left-sided unguarded tricuspid valve disease with congenitally corrected transposition of the great arteries (ccTGA) is a rare cardiac malformation, only reported a few times in the literature. Two-dimensional echocardiography (2DE) uses standard views to ... Full text Link to item Cite

Preprocedural three-dimensional planning aids in transcatheter ductal stent placement: A single-center experience.

Journal Article Catheter Cardiovasc Interv · May 1, 2020 OBJECTIVES: Describe the use of three-dimensional (3D) patent ductus arteriosus (PDA) modeling to better define ductal anatomy to improve preprocedural planning for ductal stent placement. BACKGROUND: Ductal stenting is an alternative to surgical shunting ... Full text Link to item Cite

Early cardiac dysfunction in children and young adults with perinatally acquired HIV.

Journal Article AIDS · March 15, 2020 OBJECTIVE: To define the prevalence of early cardiac dysfunction in children and young adults with perinatally acquired HIV and predictors of cardiac function. DESIGN: Cross-sectional design. METHODS: Early cardiac dysfunction was defined as left ventricul ... Full text Link to item Cite

Pulmonary Valve Endocarditis: The Potential Utility of Multimodal Imaging Prior to Surgery.

Journal Article World J Pediatr Congenit Heart Surg · March 2020 BACKGROUND: The presence of echocardiographic (echo) evidence is a major criterion for the diagnosis of infective endocarditis (IE) by modified Duke criteria. Pulmonary valve (PV) IE, however, can be challenging to identify by echo. We sought to evaluate t ... Full text Link to item Cite

Recovery of the fetal electrocardiogram for morphological analysis from two trans-abdominal channels via optimal shrinkage.

Journal Article Physiol Meas · December 2, 2019 OBJECTIVE: We propose a novel algorithm to recover fetal electrocardiogram (ECG) for both the fetal heart rate analysis and morphological analysis of its waveform from two or three trans-abdominal maternal ECG channels. APPROACH: We design an algorithm bas ... Full text Link to item Cite

Electromechanical Dyssynchrony and Clinically Silent Ventricular Dysfunction in Young Subjects with Ventricular Pacing for Congenital and Early Acquired Av Block

Journal Article Biomedical Journal of Scientific & Technical Research · August 2019 ASingle site ventricular pacing can result in electromechanical dyssynchrony and LV dysfunction. A classic pattern by strain echocardiography pattern analysis has been defined that specifically identifies electromechanical dyssynchrony. ... Cite

Agreement of an echocardiogram-based diagnosis of pulmonary hypertension in infants at risk for bronchopulmonary dysplasia among masked reviewers.

Journal Article J Perinatol · February 2019 OBJECTIVE: To evaluate the agreement of an echocardiogram-based pulmonary hypertension diagnosis in premature infants at risk for bronchopulmonary dysplasia (BPD). STUDY DESIGN: Echocardiograms from infants born ≤28 weeks post menstrual age were retrospect ... Full text Link to item Cite

Improving maternal-infant bonding after prenatal diagnosis of CHD.

Journal Article Cardiol Young · November 2018 BACKGROUND: Infants with prenatally diagnosed CHD are at high risk for adverse outcomes owing to multiple physiologic and psychosocial factors. Lack of immediate physical postnatal contact because of rapid initiation of medical therapy impairs maternal-inf ... Full text Link to item Cite

The epidemiology of heart defects

Chapter · April 30, 2018 The Visual Guide to Neonatal Cardiology is a comprehensive, highly illustrated, reference covering the evaluation, diagnosis and management of cardiac disease in the newborn. ... Cite

Strain in Complex Congenital Heart Disease in Infants and Children

Chapter · January 1, 2018 Varying degrees of heart failure is common in infants with complex single ventricular heart disease. Sometimes the heart failure is progressive without a clear etiology and unresponsive to intense pharmacotherapy creating a critical management dilemma. The ... Full text Cite

Cardiac Masses

Chapter · January 1, 2018 Echocardiography is the most common method for the detection of cardiac masses. Masses can be described as intracavitary (within chambers or great vessels, and attached to chamber walls, valves or great vessels) or intramural (located within the muscular s ... Full text Cite

Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial.

Journal Article Cardiol Young · September 2017 BACKGROUND: A few studies have evaluated the impact of clinical trial results on practice in paediatric cardiology. The Infant Single Ventricle (ISV) Trial results published in 2010 did not support routine use of the angiotensin-converting enzyme inhibitor ... Full text Link to item Cite

Activation delay-induced mechanical dyssynchrony in single-ventricle heart disease.

Journal Article Cardiol Young · September 2017 We present the case of an infant with a single functional ventricle who developed ventricular dysfunction and heart failure due to an electrical activation delay and dyssynchrony. Earlier recognition of this potentially reversible aetiology may have change ... Full text Link to item Cite

The Effect of the Superior Cavopulmonary Anastomosis on Ventricular Remodeling in Infants with Single Ventricle.

Journal Article J Am Soc Echocardiogr · July 2017 BACKGROUND: Infants with single ventricular physiology have volume and pressure overload that adversely affect ventricular mechanics. The impact of superior cavopulmonary anastomosis (SCPA) on single left ventricles versus single right ventricles is not kn ... Full text Link to item Cite

Utility and Scope of Rapid Prototyping in Patients with Complex Muscular Ventricular Septal Defects or Double-Outlet Right Ventricle: Does it Alter Management Decisions?

Journal Article Pediatr Cardiol · January 2017 Rapid prototyping facilitates comprehension of complex cardiac anatomy. However, determining when this additional information proves instrumental in patient management remains a challenge. We describe our experience with patient-specific anatomic models cr ... Full text Link to item Cite

Ultrasound Examination of the Fetal Heart.

Journal Article Obstet Gynecol Surv · January 2017 Congenital heart disease (CHD) occurs in 4-13 per 1000 births in the United States. While many risk factors for CHD have been identified, more than 90% of cases occur in low-risk patients. Guidelines for fetal cardiac screening during the second trimester ... Full text Link to item Cite

Frequent Activation Delay-Induced Mechanical Dyssynchrony and Dysfunction in the Systemic Right Ventricle.

Journal Article J Am Soc Echocardiogr · November 2016 BACKGROUND: Patients with systemic right ventricles frequently experience progressive heart failure and conduction abnormalities leading to abnormal ventricular activation. Activation delay-induced mechanical dyssynchrony can contribute to ventricular fail ... Full text Link to item Cite

Assessment of Diastolic Function in Single-Ventricle Patients After the Fontan Procedure.

Journal Article J Am Soc Echocardiogr · November 2016 BACKGROUND: Patients with functional single ventricles after the Fontan procedure have abnormal cardiac mechanics. The aims of this study were to determine factors that influence diastolic function and to describe associations of diastolic function with cu ... Full text Link to item Cite

Patterns of Mechanical Inefficiency in Pediatric Dilated Cardiomyopathy and Their Relation to Left Ventricular Function and Clinical Outcomes.

Journal Article J Am Soc Echocardiogr · March 2016 BACKGROUND: Pediatric dilated cardiomyopathy (DCM) is associated with death or transplantation and is typically considered a homogeneous process affecting global left ventricular (LV) function. However, assessment of regional abnormalities that contribute ... Full text Link to item Cite

Congenital Anomalies of the Coronary Arteries

Chapter · January 19, 2016 Congenital coronary artery abnormalities represent a diagnostic challenge to the echocardiographer, a potential life-threatening problem to the patient, and a source of great anxiety to families and the public. This chapter describes the development of the ... Full text Cite

Differences in Eccentricity Index and Systolic-Diastolic Ratio in Extremely Low-Birth-Weight Infants with Bronchopulmonary Dysplasia at Risk of Pulmonary Hypertension.

Journal Article Am J Perinatol · January 2016 OBJECTIVE: To compare the left ventricular eccentricity index (EI) and tricuspid valve systolic-diastolic (SD) ratio in infants at risk of bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). STUDY DESIGN: Review of echocardiograms performed o ... Full text Link to item Cite

Abnormalities of Fetal Situs: An Overview and Literature Review.

Journal Article Obstet Gynecol Surv · January 2016 The incidence of congenital heart disease is most commonly reported in 8 per 1000 live births. Situs anomalies are among the least common forms of congenital heart disease. This study defines situs and describes the variations of fetal situs anomalies. Sit ... Full text Link to item Cite

Right ventricular echocardiographic indices predict poor outcomes in infants with persistent pulmonary hypertension of the newborn.

Journal Article Eur Heart J Cardiovasc Imaging · November 2015 AIMS: Infants with persistent pulmonary hypertension of the newborn (PPHN) have elevated pulmonary vascular resistance that can lead to right ventricular (RV) failure and death. Clinicians must decide which infants will fail conventional therapy and requir ... Full text Link to item Cite

Comparison of invasive and non-invasive pressure gradients in aortic arch obstruction.

Journal Article Cardiol Young · October 2015 BACKGROUND: Aortic arch obstruction can be evaluated by catheter peak-to-peak gradient or by Doppler peak instantaneous pressure gradient. Previous studies have shown moderate correlation in discrete coarctation, but few have assessed correlation in patien ... Full text Link to item Cite

The influence of angle of insonation and target depth on speckle-tracking strain.

Journal Article J Am Soc Echocardiogr · May 2015 BACKGROUND: Speckle-tracking strain is almost universally cited as being independent of angle of insonation, but there are minimal confirmatory studies, and this claim may not be consistent with the known limitations of ultrasound axial and lateral spatial ... Full text Link to item Cite

Cardiac strain during upright cycle ergometry in adolescent males.

Journal Article Echocardiography · April 2015 Little evidence exists with regard to changes in cardiac strain that occur during submaximal exercise in young males. The aims of the study were to evaluate the changes that occur in longitudinal (L), radial (R), and endocardial circumferential (EC) strain ... Full text Link to item Cite

Evaluation of Right Ventricular Myocardial Mechanics Using Velocity Vector Imaging of Cardiac MRI Cine Images in Transposition of the Great Arteries Following Atrial and Arterial Switch Operations.

Journal Article Congenit Heart Dis · 2015 OBJECTIVE: The aim of the study was to determine right and left ventricle deformation parameters in patients with transposition of the great arteries who had undergone atrial or arterial switch procedures. SETTING: Patients with transposition are born with ... Full text Link to item Cite

Classic-pattern dyssynchrony and electrical activation delays in pediatric dilated cardiomyopathy.

Journal Article J Am Soc Echocardiogr · September 2014 BACKGROUND: Progressive heart failure leading to transplantation or death is common in pediatric dilated cardiomyopathy (DCM), and treatment options are limited. Select children with DCM have improved after cardiac resynchronization therapy (CRT), but pred ... Full text Link to item Cite

Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population.

Journal Article J Am Soc Echocardiogr · April 2014 BACKGROUND: Although quantitative right ventricular (RV) strain analysis may be useful in congenital and acquired heart disease populations with RV failure, a comprehensive, standardized approach is lacking. An 18-segment RV strain analysis obtained from t ... Full text Link to item Cite

Sildenafil exposure and hemodynamic effect after Fontan surgery.

Journal Article Pediatr Crit Care Med · January 2014 OBJECTIVE: Determine sildenafil exposure and hemodynamic effect in children after Fontan single-ventricle surgery. DESIGN: Prospective dose-escalation trial. SETTING: Single-center pediatric catheterization laboratory. PATIENTS: Nine children post Fontan s ... Full text Link to item Cite

Echocardiographic Assessment of Global and Segmental Strain Using Velocity Vector Imaging

Chapter · November 30, 2013 This two volume textbook is a practical guide to echocardiography for trainees. Divided into seven sections, the book begins with an introduction to the history and basics of echocardiography. ... Cite

Predictors of disease progression in pediatric dilated cardiomyopathy.

Journal Article Circ Heart Fail · November 2013 BACKGROUND: Despite medical advances, children with dilated cardiomyopathy (DCM) remain at high risk of death or need for cardiac transplantation. We sought to identify predictors of disease progression in pediatric DCM. METHODS AND RESULTS: The Pediatric ... Full text Link to item Cite

Abnormal agitated saline study results after tetralogy of Fallot repair.

Journal Article Echocardiography · November 2013 Residual intracardiac or extracardiac shunting is frequently seen in patients with repaired congenital heart disease and can cause systemic hypoxemia. We present the case of an adult with tetralogy of Fallot who underwent two corrective surgical procedures ... Full text Link to item Cite

Hybrid cutting balloon dilatation for treatment of cor triatriatum sinister in a cat.

Journal Article J Vet Cardiol · September 2013 A hybrid surgical approach and balloon dilatation were performed successfully in a cat with cor triatriatum sinister and clinical signs of congestive heart failure. Left lateral thoracotomy was used to access the heart and cutting balloon followed by stand ... Full text Link to item Cite

Sildenafil exposure and hemodynamic effect after stage II single-ventricle surgery.

Journal Article Pediatr Crit Care Med · July 2013 OBJECTIVES: To determine sildenafil exposure and hemodynamic effect in children after stage II single-ventricle surgery. DESIGN: Prospective, dose escalation trial. SETTING: Single-center, pediatric catheterization laboratory. PATIENTS: Twelve children pos ... Full text Link to item Cite

Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents.

Journal Article Am J Obstet Gynecol · January 2013 OBJECTIVE: The importance of maternal autoantibody levels in congenital heart block and elucidation of maternal factors that may reduce disease burden require further clarification. STUDY DESIGN: Pregnancies complicated by maternal anti-Ro antibodies from ... Full text Link to item Cite

Cardiac Strain During Exercise In Adolescent Males

Conference MEDICINE AND SCIENCE IN SPORTS AND EXERCISE · May 1, 2012 Link to item Cite

Orthostatic effects on echocardiographic measures of ventricular function.

Journal Article Echocardiography · May 2012 Orthostatic-induced alterations in Doppler echocardiographic measures of ventricular function have not been well-defined. Identifying such changes may provide useful insights regarding the responses of these measures to variations in ventricular loading co ... Full text Link to item Cite

Isolated right subclavian artery arising from the right pulmonary artery via a right-sided ductus arteriosus with associated pulmonary steal phenomenon.

Journal Article Cardiol Young · April 2012 We present a patient with DiGeorge syndrome and an isolated right subclavian artery arising from the right pulmonary artery via a right-sided ductus arteriosus. The patient showed a subclavian and pulmonary steal with perfusion of the right arm and right l ... Full text Link to item Cite

Pulmonary atresia and ventricular septal defect with aortopulmonary collaterals in an adult dog.

Journal Article J Vet Cardiol · December 2011 Pulmonary atresia and ventricular septal defect (PA-VSD) was diagnosed in a 2-year-old castrated male Terrier mix. Transthoracic echocardiography identified a large ventricular septal defect, overriding aorta and severe right ventricular hypertrophy. A mai ... Full text Link to item Cite

Non-geometric echocardiographic indices of ventricular function in patients with a Fontan circulation.

Journal Article J Am Soc Echocardiogr · November 2011 BACKGROUND: Complex anatomy and limited windows complicate echocardiographic assessments of ventricular function in Fontan patients. For the Pediatric Heart Network Fontan Cross-Sectional Study, data were acquired from which mean ventricular pressure chang ... Full text Link to item Cite

Maternal valvular heart disease in pregnancy.

Journal Article Obstet Gynecol Surv · September 2011 UNLABELLED: Valvular heart disease is common in pregnancy. Maternal physiology changes significantly during gestation with substantial increases in cardiac output and blood volume; this can cause unmasking or worsening of cardiac disease. Acquired valvular ... Full text Link to item Cite

Time-of-day effect on cardiac responses to progressive exercise.

Journal Article Chronobiol Int · August 2011 This study was designed to examine time-of-day effects on markers of cardiac functional capacity during a standard progressive cycle exercise test. Fourteen healthy, untrained young males (mean ± SD: 17.9 ± 0.7 yrs of age) performed identical maximal cycle ... Full text Link to item Cite

Respiratory Muscle Function and Ventilatory Patterns in Adolescent Males

Conference Medicine & Science in Sports & Exercise · May 2011 Full text Cite

Bilateral superior vena cavae with anomalous drainage of the right-sided superior vena cava

Journal Article Society of Cardiovascular Magnatic Resonance Website · March 1, 2011 Link to item Cite

Arrhythmias in patients with hypoplastic left heart syndrome.

Journal Article Am Heart J · January 2011 BACKGROUND: Mortality between stage I and II palliation for hypoplastic left heart syndrome (HLHS) has been associated with arrhythmias. The stage-related proportion, associations, and clinical impact of arrhythmias in patients with HLHS have not been eval ... Full text Link to item Cite

Use of cardiac magnetic resonance imaging to evaluate cardiac structure, function and fibrosis in children with infantile Pompe disease on enzyme replacement therapy.

Journal Article Mol Genet Metab · December 2010 BACKGROUND: Pompe disease (acid α-glucosidase deficiency) is one of several lysosomal storage diseases amenable to treatment with enzyme replacement therapy (ERT). While echocardiography (echo) has been the standard method to evaluate the cardiac response ... Full text Link to item Cite

Enalapril in infants with single ventricle: results of a multicenter randomized trial.

Journal Article Circulation · July 27, 2010 BACKGROUND: Angiotensin-converting enzyme inhibitor therapy improves clinical outcome and ventricular function in adults with heart failure. Infants with single-ventricle physiology have poor growth and are at risk for abnormalities in ventricular systolic ... Full text Link to item Cite

Novel transatrial septoplasty technique for neonates with hypoplastic left heart syndrome and an intact or highly restrictive atrial septum.

Journal Article Pediatr Cardiol · May 2010 Two patients born with hypoplastic left heart syndrome and an intact or highly restrictive atrial septum requiring emergent intervention are presented. For both patients, rapid septoplasty was performed using a hybrid approach involving direct atrial punct ... Full text Link to item Cite

Double aortic arch with aortic atresia and left-sided type B interruption.

Journal Article Congenit Heart Dis · 2010 Aortic valve atresia with interruption of the aortic arch is an extremely rare anomaly; only eleven cases of this anomaly have been reported to date. In the absence of additional sources of blood flow to the ascending aorta, aortic valve atresia with inter ... Full text Link to item Cite

Intracardiac echocardiography in congenital heart disease.

Journal Article J Cardiovasc Transl Res · March 2009 The use of intracardiac echocardiography (ICE) in congenital heart disease has become well established over the past 7 years since its introduction into clinical imaging. The greatest experience has been to guide percutaneous device closures of secundum at ... Full text Link to item Cite

Global longitudinal cardiac strain and strain rate for assessment of fetal cardiac function: novel experience with velocity vector imaging.

Journal Article Echocardiography · January 2009 BACKGROUND: Cardiac strain and strain rate are new methods to quantitate fetal cardiac function. Doppler-based techniques are regional measurements limited by angle of insonation. Newer feature-tracking algorithms permit angle independent measurements from ... Full text Link to item Cite

Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy.

Journal Article Vaccine · December 9, 2008 A trial to evaluate the safety and immunogenicity of recombinant modified vaccinia Ankara (MVA) and fowlpox (FP) vectors expressing multiple HIV-1 proteins was conducted in twenty HIV-1 infected youth with suppressed viral replication on HAART. The MVA and ... Full text Link to item Cite

Use of the monoplane intracardiac imaging probe in high-risk infants during congenital heart surgery.

Journal Article Echocardiography · October 2008 UNLABELLED: Imaging options are limited in high-risk infants with small or abnormal oropharyngeal anatomy during congenital heart surgery. METHODS: All cases in which the monoplane intracardiac echo probe was used for transesophageal intraoperative imaging ... Full text Link to item Cite

An exploratory study of cardiac function and oxygen uptake during cycle ergometry in overweight children.

Journal Article Obesity (Silver Spring) · November 2007 OBJECTIVE: Obesity has been proposed to negatively impact cardiac function in overweight (OW) individuals. The relationship between diastolic dysfunction and oxygen uptake (Vo(2)) kinetics is equivocal. This exploratory investigation evaluated the relation ... Full text Link to item Cite

A patient with congenital heart disease and ventricular tachycardia: what is the course of the device lead?

Journal Article Pacing Clin Electrophysiol · November 2007 A 16-year-old boy with Ebstein's anomaly of the tricuspid valve developed exercise-induced rapid ventricular tachycardia. He had previously undergone tricuspid valvuloplasty and bidirectional cavopulmonary anastamosis due to progressive symptoms. A single- ... Full text Link to item Cite

Cost-effectiveness of screening for congenital heart block in pregnancies at risk of neonatal lupus

Conference American Journal of Obstetrics and Gynecology · December 2006 Full text Cite

Invasive Gemella morbillorum infections: Two pediatric cases

Journal Article Infections in Medicine · August 1, 2006 Gemella morbillorum, a resident of oral, upper airway, GI, and genitourinary flora, is believed to cause invasive infections only in patients with predisposing factors, such as immunodeficiency or history of dental or GI procedures. It has been rarely asso ... Cite

Risk factors for cerebrovascular events following fontan palliation in patients with a functional single ventricle.

Journal Article Am J Cardiol · August 15, 2005 The risk for cerebrovascular events (CVEs) is increased in children with functional single ventricles (FSVs). However, there are limited data indicating the prevalence of CVEs or the role of preventative therapy. To measure the prevalence of clinically evi ... Full text Link to item Cite

Comparison of simultaneous invasive and noninvasive measurements of pressure gradients in congenital aortic valve stenosis.

Journal Article J Am Soc Echocardiogr · December 2002 PURPOSE: Congenital aortic valve stenosis is a common problem in pediatric cardiology. The catheter peak to peak systolic gradient is the accepted standard used for prognosis and intervention, but noninvasive correlation in pediatric patients is frequently ... Full text Link to item Cite