Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment.
Publication
, Journal Article
Harrington, J; McCrary, AW; Nguyen, M; Nyandiko, W; Barker, PCA; Koech, M; Thielman, NM; Muehlbauer, MJ; Shah, SH; Bloomfield, GS
Published in: AIDS
June 1, 2024
People with HIV are at increased risk of cardiac dysfunction; however, limited tools are available to identify patients at highest risk for future cardiac disease. We performed proteomic profiling using plasma samples from children and young adults with perinatally acquired HIV without clinical cardiac disease, comparing samples from participants with and without an abnormal myocardial performance index (MPI). We identified four proteins independently associated with subclinical cardiac dysfunction: ST2, CA1, EN-RAGE, and VSIG2.
Duke Scholars
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
June 1, 2024
Volume
38
Issue
7
Start / End Page
1090 / 1093
Location
England
Related Subject Headings
- Young Adult
- Virology
- Proteomics
- Male
- Humans
- Heart Diseases
- HIV Infections
- Fibrosis
- Female
- Child
Citation
APA
Chicago
ICMJE
MLA
NLM
Harrington, J., McCrary, A. W., Nguyen, M., Nyandiko, W., Barker, P. C. A., Koech, M., … Bloomfield, G. S. (2024). Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment. AIDS, 38(7), 1090–1093. https://doi.org/10.1097/QAD.0000000000003879
Harrington, Josephine, Andrew W. McCrary, Maggie Nguyen, Winstone Nyandiko, Piers C. A. Barker, Myra Koech, Nathan M. Thielman, Michael J. Muehlbauer, Svati H. Shah, and Gerald S. Bloomfield. “Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment.” AIDS 38, no. 7 (June 1, 2024): 1090–93. https://doi.org/10.1097/QAD.0000000000003879.
Harrington J, McCrary AW, Nguyen M, Nyandiko W, Barker PCA, Koech M, et al. Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment. AIDS. 2024 Jun 1;38(7):1090–3.
Harrington, Josephine, et al. “Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment.” AIDS, vol. 38, no. 7, June 2024, pp. 1090–93. Pubmed, doi:10.1097/QAD.0000000000003879.
Harrington J, McCrary AW, Nguyen M, Nyandiko W, Barker PCA, Koech M, Thielman NM, Muehlbauer MJ, Shah SH, Bloomfield GS. Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment. AIDS. 2024 Jun 1;38(7):1090–1093.
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
June 1, 2024
Volume
38
Issue
7
Start / End Page
1090 / 1093
Location
England
Related Subject Headings
- Young Adult
- Virology
- Proteomics
- Male
- Humans
- Heart Diseases
- HIV Infections
- Fibrosis
- Female
- Child